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A fractional differential constitutive model for dynamic stress intensity factors of an anti-plane crack in viscoelastic materials 被引量:2
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作者 Run-Tao Zhan Zhao-Xia Li Lei Wang 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2014年第3期403-409,共7页
Fractional differential constitutive relationships are introduced to depict the history of dynamic stress inten- sity factors (DSIFs) for a semi-infinite crack in infinite viscoelastic material subjected to anti-pla... Fractional differential constitutive relationships are introduced to depict the history of dynamic stress inten- sity factors (DSIFs) for a semi-infinite crack in infinite viscoelastic material subjected to anti-plane shear impact load. The basic equations which govern the anti-plane deformation behavior are converted to a fractional wave-like equation. By utilizing Laplace and Fourier integral transforms, the fractional wave-like equation is cast into an ordinary differential equation (ODE). The unknown function in the solution of ODE is obtained by applying Fourier transform directly to the boundary conditions of fractional wave-like equation in Laplace domain instead of solving dual integral equations. Analytical solutions of DSIFs in Laplace domain are derived by Wiener-Hopf technique and the numerical solutions of DSIFs in time domain are obtained by Talbot algorithm. The effects of four parameters α, β, b1, b2 of the fractional dif- ferential constitutive model on DSIFs are discussed. The numerical results show that the present fractional differential constitutive model can well describe the behavior of DSIFs of anti-plane fracture in viscoelastic materials, and the model is also compatible with solutions of DSIFs of anti-plane fracture in elastic materials. 展开更多
关键词 Dynamic fracture Stress intensity factors fractional differentiation - Anti-plane fracture Viscoelasticmaterial WIENER-HOPF
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Experimental study of relationship between average isotopic fractionation factor and evaporation rate 被引量:1
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作者 Tao WANG Wei-min BAO +6 位作者 Hai-li XU Zhen ZHU Si-min QU Peng SHI Hai-ying HU Rui-qi FAN Qian LI 《Water Science and Engineering》 EI CAS 2010年第4期394-404,共11页
Isotopic fractionation is the basis of tracing the water cycle using hydrogen and oxygen isotopes. Isotopic fractionation factors in water evaporating from free water bodies are mainly affected by temperature and rela... Isotopic fractionation is the basis of tracing the water cycle using hydrogen and oxygen isotopes. Isotopic fractionation factors in water evaporating from free water bodies are mainly affected by temperature and relative humidity, and vary significantly with these atmospheric factors over the course of a day. The evaporation rate (E) can reveal the effects of atmospheric factors. Therefore, there should be a certain functional relationship between isotopic fractionation factors and E. An average isotopic fractionation factor ( t~* ) was defined to describe isotopic differences between vapor and liquid phases in evaporation with time intervals of days. The relationship between or* and E based on the isotopic mass balance was investigated through an evaporation pan experiment with no inflow. The experimental results showed that the isotopic compositions of residual water were more enriched with time; tr* was affected by air temperature, relative humidity, and other atmospheric factors, and had a strong functional relation with E. The values of 0~* can be easily calculated with the known values of E, the initial volume of water in the pan, and isotopic compositions of residual water. 展开更多
关键词 average isotopic fractionation factor evaporation rate hydrogen and oxygen isotopes
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Equilibrium and kinetic Si isotope fractionation factors and their implications for Si isotope distributions in the Earth's surface environments 被引量:3
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作者 Hong-tao He Siting Zhang +1 位作者 Chen Zhu Yun Liu 《Acta Geochimica》 EI CAS CSCD 2016年第1期15-24,共10页
Several important equilibrium Si isotope fractionation factors among minerals,organic molecules and the H_4SiO_4 solution are complemented to facilitate the explanation of the distributions of Si isotopes in Earth'... Several important equilibrium Si isotope fractionation factors among minerals,organic molecules and the H_4SiO_4 solution are complemented to facilitate the explanation of the distributions of Si isotopes in Earth's surface environments.The results reveal that,in comparison to aqueous H_4SiO_4,heavy Si isotopes will be significantly enriched in secondary silicate minerals.On the contrary,quadra-coordinated organosilicon complexes are enriched in light silicon isotope relative to the solution.The extent of ^(28)Si-enrichment in hyper-coordinated organosilicon complexes was found to be the largest.In addition,the large kinetic isotope effect associated with the polymerization of monosilicic acid and dimer was calculated,and the results support the previous statement that highly ^(28)Sienrichment in the formation of amorphous quartz precursor contributes to the discrepancy between theoretical calculations and field observations.With the equilibrium Si isotope fractionation factors provided here,Si isotope distributions in many of Earth's surface systems can be explained.For example,the change of bulk soil δ^(30)Si can be predicted as a concave pattern with respect to the weathering degree,with the minimum value where allophane completely dissolves and the total amount of sesquioxides and poorly crystalline minerals reaches their maximum.When,under equilibrium conditions,the well-crystallized clays start to precipitate from the pore solutions,the bulk soil δ^(30)Si will increase again and reach a constant value.Similarly,the precipitation of crystalline smectite and the dissolution of poorly crystalline kaolinite may explain the δ^(30)Si variations in the ground water profile.The equilibrium Si isotope fractionations among the quadracoordinated organosilicon complexes and the H_4SiO_4solution may also shed light on the Si isotope distributions in the Si-accumulating plants. 展开更多
关键词 Si isotopes Equilibrium fractionation factor Quantum chemistry calculation Cluster model Kinetic isotope effect
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FRACTIONAL (g, f)-FACTORS OF GRAPHS 被引量:9
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作者 刘桂真 张兰菊 《Acta Mathematica Scientia》 SCIE CSCD 2001年第4期541-545,共5页
This paper presents a new proof of a charaterization of fractional (g, f)-factors of a graph in which multiple edges are allowed. From the proof a polynomial algorithm for finding the fractional (g, f)-factor can be i... This paper presents a new proof of a charaterization of fractional (g, f)-factors of a graph in which multiple edges are allowed. From the proof a polynomial algorithm for finding the fractional (g, f)-factor can be induced. 展开更多
关键词 fractional (g f)-factor augmenting path GRAPH
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ON THE CHOICES OF ACCELERATING CONVERGENCE FACTORS FOR LIMIT PERIODIC CONTINUED FRACTION K(an/1) 被引量:4
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作者 唐烁 檀结庆 朱功勤 《Numerical Mathematics A Journal of Chinese Universities(English Series)》 SCIE 1996年第1期62-70,共9页
There are many accelerating convergence factors (ACFs) for limit periodic continued fraction K(an/1)(an→a≠0). In this paper, some characteristics and comparative theorems are ob tained on ACFs. Two results are given... There are many accelerating convergence factors (ACFs) for limit periodic continued fraction K(an/1)(an→a≠0). In this paper, some characteristics and comparative theorems are ob tained on ACFs. Two results are given for most frequently used ACFs. 展开更多
关键词 LIMIT PERIODIC continued fraction accelerating CONVERGENCE factor.
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The Factors for Transformation between the Fractions of Speciation of Trace Metals in Lake Sediments 被引量:1
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作者 ZHANG Hui 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2017年第2期753-754,共2页
Objective Despite the fact that the bioavailability of trace metals indicated by their speciation has been an indispensable parameter in the assessment and treatment of the environmental pollution of trace metals, ma... Objective Despite the fact that the bioavailability of trace metals indicated by their speciation has been an indispensable parameter in the assessment and treatment of the environmental pollution of trace metals, many studies have suggested that the bioavailability of trace metals may change according to the conditions of the environment, and the speciation of trace metals can also transform between some fractions. These transformations are related with these factors such as the compositions, microorganism, time, and other physical-chemical conditions of the system. Our work aims to systematically investigate and probe the factors to affect the transformation aside from analysis at certain time-place. The results of these understanding and investigations can be used for reasonably determining the allocation of financial and technical resources in natural and engineered processes, with bringing about inspirations from the evolution of the speciation of the trace metals on environmental impacts. 展开更多
关键词 The factors for Transformation between the fractions of Speciation of Trace Metals in Lake Sediments Lake
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Time and Space Fractional Schrdinger Equation with Fractional Factor
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作者 Pei Xiang Yong-Xin Guo Jing-Li Fu 《Communications in Theoretical Physics》 SCIE CAS CSCD 2019年第1期16-26,共11页
In this paper, we introduce a new definition of fractional derivative which contains a fractional factor, and its physical meanings are given. When studying the fractional Schrdinger equation(FSE) with this form of fr... In this paper, we introduce a new definition of fractional derivative which contains a fractional factor, and its physical meanings are given. When studying the fractional Schrdinger equation(FSE) with this form of fractional derivative, the result shows that under the description of time FSE with fractional factor, the probability of finding a particle in the whole space is still conserved. By using this new definition to construct space FSE, we achieve a continuous transition from standard Schrdinger equation to the fractional one. When applying this form of Schrdinger equation to a particle in an infinite symmetrical square potential well, we find that the probability density distribution loses spatial symmetry and shows a kind of attenuation property. For the situation of a one-dimensional infinite δ potential well,the first derivative of time-independent wave function Φ to space coordinate x can be continuous everywhere when the particle is at some special discrete energy levels, which is much different from the standard Schrdinger equation. 展开更多
关键词 fractional derivative fractional factor fractional Schr¨odinger equation Bessel function
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PROPERTIES OF FRACTIONAL k-FACTORS OF GRAPHS
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作者 刘桂真 张兰菊 《Acta Mathematica Scientia》 SCIE CSCD 2005年第2期301-304,共4页
In this paper the properties of some maximum fractional [0, k]-factors of graphs are presented. And consequently some results on fractional matchings and fractional 1-factors are generalized and a characterization of ... In this paper the properties of some maximum fractional [0, k]-factors of graphs are presented. And consequently some results on fractional matchings and fractional 1-factors are generalized and a characterization of fractional k-factors is obtained. 展开更多
关键词 fractional (g f)-factor. fractional matching fractional k-factor
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Analysis of the Diurnal Pattern of Evaporative Fraction and Its Controlling Factors over Croplands in the Northern China
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作者 YANG Da-wen CHEN He LEI Hui-min 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2013年第8期1316-1329,共14页
A key issue of applying remotely sensed data to estimate evapotranspiration (ET) for water management is extrapolating instantaneous latent heat flux (LE) at satellite over-passing time to daily ET total. At prese... A key issue of applying remotely sensed data to estimate evapotranspiration (ET) for water management is extrapolating instantaneous latent heat flux (LE) at satellite over-passing time to daily ET total. At present, the most commonly used extrapolation methods have the same assumption that evaporative fraction (EF) can be treated as constant during daytime (so-called EF self-preservation). However, large errors are reported by many documents over various ecosystems with the same approach, which indicates that further analysis of the diurnal pattern of EF is still necessary. The aim of this study is to examine the diurnal pattern of EF under fair weather conditions, then to analyze the dependencies of EF to meteorological and plant factors. Long-term flux observations at four sites over semi-arid and semi-humid climate regions in the northern China are used to analyze the EF diumal pattern. Results show that the EF self-preservation assumption no longer holds over growing seasons of crops. However, the ratio of reference ET to available energy is almost constant during the daytime, which implies the climate factors do not have much effect on the variability of EF. The analysis of diurnal pattern of air temperature, vapor pressure deficiency (VPD), and relative humidity (RH) confirms the assumption that ET diurnal pattern is mainly influenced by stomatal regulation. 展开更多
关键词 evaporative fraction daily evapotranspiration meteorological factor vegetation fraction northem China
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Preventive fraction of physical fitness on risk factors in cardiac patients:Retrospective epidemiological study
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作者 Maxime Caru Laurence Kern +1 位作者 Marc Bousquet Daniel Curnier 《World Journal of Cardiology》 CAS 2018年第4期26-34,共9页
AIM To quantify the preventive fraction of physical fitness on the risk factors in patients with cardiovascular diseases(CVDs).METHODS A total of 249 subjects(205 men and 44 women) suffering from CVD were categorized ... AIM To quantify the preventive fraction of physical fitness on the risk factors in patients with cardiovascular diseases(CVDs).METHODS A total of 249 subjects(205 men and 44 women) suffering from CVD were categorized into four groups, according to their percentage of physical fitness. We calculated the odds ratio to obtain the preventive fraction in order to evaluate the impact of the physical fitness level on the risk factors(i.e., abdominal obesity, depression, diabetes, dyslipidemia, hypertension, obesity, overweight and smoking).RESULTS It is observed that a normal physical fitness level is sufficient to induce a preventive action on abdominal obesity(38%), diabetes(12%), hypertension(33%), obesity(12%) and overweight(11%). Also, the preventive fraction increases with the level of physical fitness, in particular for hypertension(36%) and overweight(16%). A high physical fitness level does not necessarily induce a preventive action in most risk factors, excluding depression. CONCLUSION This is the first study which demonstrates that reaching a normal physical fitness level is enough to induce a protection for some risk factors, despite having a CVD. 展开更多
关键词 Physical FITNESS CARDIOVASCULAR diseases Risk factors PREVENTIVE fraction EPIDEMIOLOGICAL study
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Binding Number and Fractional k-Factors of Graphs
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作者 Renying Chang 《Journal of Applied Mathematics and Physics》 2024年第7期2594-2600,共7页
In this paper, we consider the relationship between the binding number and the existence of fractional k-factors of graphs. The binding number of G is defined by Woodall as bind(G)=min{ | NG(X) || X |:∅≠X⊆V(G) }. It ... In this paper, we consider the relationship between the binding number and the existence of fractional k-factors of graphs. The binding number of G is defined by Woodall as bind(G)=min{ | NG(X) || X |:∅≠X⊆V(G) }. It is proved that a graph G has a fractional 1-factor if bind(G)≥1and has a fractional k-factor if bind(G)≥k−1k. Furthermore, it is showed that both results are best possible in some sense. 展开更多
关键词 Binding Number fractional k-factor fractional Matching Independent Set Covering Set
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Factorization of Operators in Krein Spaces and Linear-Fractional Relations of Operator Balls
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作者 Victor Anatoly Khatskevich Valery Anatoly Senderov 《Advances in Pure Mathematics》 2013年第1期29-33,共5页
We consider plus-operators in Krein spaces and generated operator linear fractional relations of the following form: . We study some special type of factorization for plus-operators T, among them the following one: T ... We consider plus-operators in Krein spaces and generated operator linear fractional relations of the following form: . We study some special type of factorization for plus-operators T, among them the following one: T = BU, where B is a lower triangular plus-operator, U is a J-unitary operator. We apply the above factorization to the study of basical properties of relations (1), in particular, convexity and compactness of their images with respect to the weak operator topology. Obtained results we apply to the known Koenigs embedding problem, the Krein-Phillips problem of existing of invariant semidefinite subspaces for some families of plus-operators and to some other fields. 展开更多
关键词 Krein Space LINEAR fractionAL Relation Plus-Operator factorIZATION
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超脉冲CO_(2)点阵激光联合人表皮生长因子治疗痤疮萎缩性瘢痕的回顾性分析
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作者 肖汉龙 方于民 +2 位作者 王军 汪莹 孙江华 《中国医疗美容》 2026年第2期1-3,29,共4页
目的回顾分析超脉冲CO_(2)点阵激光联合人表皮生长因子治疗痤疮萎缩性瘢痕的临床疗效。方法2022年1月至2024年1月武警湖北省总队医院收治的痤疮萎缩性瘢痕60例患者,采用超脉冲CO_(2)点阵激光联合人表皮生长因子治疗。一共治疗3次,每次... 目的回顾分析超脉冲CO_(2)点阵激光联合人表皮生长因子治疗痤疮萎缩性瘢痕的临床疗效。方法2022年1月至2024年1月武警湖北省总队医院收治的痤疮萎缩性瘢痕60例患者,采用超脉冲CO_(2)点阵激光联合人表皮生长因子治疗。一共治疗3次,每次间隔时间为3个月。疗程结束1个月后评价临床疗效。结果本研究治疗总有效率为88.3%(53/60)。患者疗程结束1个月后ECCA评分显著低于治疗前ECCA评分,差异有统计学意义(P<0.01);疗程结束6个月后ECCA评分显著低于疗程结束1个月后ECCA评分,差异有统计学意义(P<0.01)。结论超脉冲CO_(2)点阵激光联合人表皮生长因子治疗痤疮萎缩性瘢痕疗效确切,不良反应少,远期效果好。 展开更多
关键词 点阵激光 人表皮生长因子 痤疮 萎缩性瘢痕
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老年射血分数保留心力衰竭患者的衰弱水平及影响因素
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作者 贾研研 李萌柳 +1 位作者 姬洪涛 郭山岭 《河南医学研究》 2026年第2期273-276,共4页
目的探讨老年射血分数保留心力衰竭(HFp EF)患者合并衰弱的临床特征,并结合实验室检查和超声心动图参数探究其影响因素。方法选取2021年1月至2023年1月在医院心内科住院、年龄≥65岁的均处于慢性心力衰竭稳定期的HFp EF患者100例。入院... 目的探讨老年射血分数保留心力衰竭(HFp EF)患者合并衰弱的临床特征,并结合实验室检查和超声心动图参数探究其影响因素。方法选取2021年1月至2023年1月在医院心内科住院、年龄≥65岁的均处于慢性心力衰竭稳定期的HFp EF患者100例。入院后24 h内采用Fried衰弱评估标准评估患者的衰弱情况,并将患者分为非衰弱组(68例)和衰弱组(32例)。收集患者的临床资料,包括性别、年龄等一般资料、吸烟史、合并疾病、营养风险、实验室检查结果及超声心动图参数,采用多因素logistic回归分析探讨老年HFp EF患者衰弱得分及衰弱的影响因素。结果衰弱组患者的年龄、纽约心脏病协会心功能分级(NYHA)Ⅲ级占比、营养风险比例、脑利尿钠肽(BNP)水平高于非衰弱组(P<0.05),血红蛋白(Hb)、血清25羟基维生素D[25(OH)D]水平低于非衰弱组(P<0.05)。左室舒张末内径(LVEDD)、左室收缩末内径(LVESD)、主动脉内径(AOD)和室间隔厚度(IVS)高于非衰弱组(P<0.05);两组左室射血分数(LVEF)、左房内径(LAD)和左室后壁厚度(LVPW)差异无统计学意义(P>0.05)。营养风险筛查量表(NRS2002)评估营养风险,多因素logistic回归分析结果显示年龄、NYHA分级、营养风险、BNP水平和AOD是老年HFp EF患者合并衰弱的独立危险因素(P<0.05)。结论老年HFp EF患者合并衰弱的发生率为32%,高龄、高NYHA分级、高营养风险、高BNP水平和高AOD是老年HFp EF患者合并衰弱的独立危险影响因素。 展开更多
关键词 射血分数保留心力衰竭 衰弱 影响因素
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HFrEF易损期患者院外随访视角下非计划再入院现况及危险因素
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作者 曹莹莹 熊梦 焦琳 《中国循证心血管医学杂志》 2026年第1期76-80,共5页
目的观察分析射血分数降低型心力衰竭(HFrEF)易损期患者院外随访视角下非计划再入院现况及危险因素。方法选取2023年9月至2024年6月于武汉大学中南医院就诊的162例HFrEF易损期患者,收集患者临床资料、实验室指标、影像学指标。院外随访... 目的观察分析射血分数降低型心力衰竭(HFrEF)易损期患者院外随访视角下非计划再入院现况及危险因素。方法选取2023年9月至2024年6月于武汉大学中南医院就诊的162例HFrEF易损期患者,收集患者临床资料、实验室指标、影像学指标。院外随访3个月,统计患者非计划再入院发生情况及危险因素。结果随访期间,162例HFrEF易损期患者出现非计划再入院31例,发生率为19.14%。再入院组吸烟、饮酒、NYHA分级、血小板计数(PLT)<125×10^(9)/L、N末端脑钠肽前体(NT-proBNP)>400 ng/L、左室射血分数(LVEF)<40%、营养不良的比例比较,差异有统计学意义(P<0.050)。Logistic回归分析显示:吸烟、饮酒、NT-proBNP>400 ng/L、LVEF<40%、营养不良是HFrEF易损期患者非计划再入院的危险因素(P<0.05)。回归方程为:Logit(P)=5.014+1.362×(吸烟)+1.228×(饮酒)+1.936×(NT-proBNP>400 ng/L)+1.696×(LVEF<40%)+1.184×(营养不良)。在此基础上通过绘制ROC曲线对模型的预测价值予以评价,结果显示:当最佳截断值>12.42时,AUC=0.867,95%CI:0.836~0.890,提示该模型对事件的发生预测价值较好。结论且吸烟、饮酒、NT-proBNP>400 ng/L、LVEF<40%、营养不良是HFrEF易损期患者非计划再入院的危险因素,根据其危险因素构建回归方程并绘制ROC曲线,可预测HFrEF易损期患者非计划再入院风险,具有一定的临床价值。 展开更多
关键词 射血分数降低心力衰竭 非计划再入院 危险因素 预测价值
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双靶联合放疗在HER-2阳性乳腺癌保乳术后的应用
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作者 刘洋 刘晶晶 《安徽医学》 2026年第3期301-307,共7页
目的基于倾向性评分匹配法(PSM)分析双靶联合大分割放疗在人表皮生长因子受体-2(HER-2)阳性乳腺癌患者保乳术后中的应用。方法回顾性分析唐山市人民医院放化六科2021年12月至2024年6月132例行保乳术及术后辅助治疗的HER-2阳性乳腺癌患... 目的基于倾向性评分匹配法(PSM)分析双靶联合大分割放疗在人表皮生长因子受体-2(HER-2)阳性乳腺癌患者保乳术后中的应用。方法回顾性分析唐山市人民医院放化六科2021年12月至2024年6月132例行保乳术及术后辅助治疗的HER-2阳性乳腺癌患者的临床资料,采用PSM按1∶1最近邻匹配法匹配,匹配后双靶组(双靶联合大分割放疗)和单靶组(单靶联合大分割放疗)各46例患者。比较两组患者血清多肽特异性抗原(TPS)、糖类抗原153(CA153)、血管内皮生长因子(VEGF)、VEGF受体2(VEGFR2)水平差异,比较两组患者不良反应发生率及随访情况。结果相较于治疗前,治疗后6个月两组血清TPS、CA153水平均降低,相较于单靶组,双靶组治疗后6个月血清TPS、CA153水平更低(P<0.05);相较于治疗前,治疗后6个月两组血清VEGF、VEGFR2水平均降低,相较于单靶组,双靶组治疗后6个月血清VEGF、VEGFR2水平更低(P<0.05);两组不良反应发生率差异无统计学意义(P>0.05);双靶组中位随访时间为17.5个月(范围5~35个月),单靶组为17.0个月(范围5~34个月),两组中位随访时间差异无统计学意义(log-rank检验χ^(2)=0.127,P=0.725),具有良好可比性。Kaplan-Meier生存分析显示,双靶组PFS为94.4%高于单靶组的85.2%,差异有统计学意义(log-rank检验χ^(2)=4.795,P=0.029)。随访期间,双靶组未出现死亡事件,而单靶组观察到4例死亡事件,2年总生存期率略低(log-rank检验χ^(2)=2.841,P=0.092)。结论HER-2阳性乳腺癌患者保乳术后采用双靶联合大分割放疗可以提高无进展生存期,降低血清TPS、CA153、VEGF、VEGFR2水平,临床需根据患者实际病情选择合适的靶向治疗手段。 展开更多
关键词 双靶 大分割放疗 人表皮生长因子受体-2阳性 乳腺癌 保乳术 倾向性评分匹配法
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原发性高血压合并射血分数降低的心力衰竭患者易损期预后影响因素分析
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作者 张露 陆红红 周碧蓉 《中国循证心血管医学杂志》 2026年第1期53-58,共6页
目的探讨原发性高血压合并射血分数降低的心力衰竭患者易损期预后的影响因素。方法收集2022年12月至2024年10月于安徽医科大学第一附属医院门诊及住院的263例原发性高血压合并射血分数降低的心力衰竭患者的一般资料及预后资料。所有患... 目的探讨原发性高血压合并射血分数降低的心力衰竭患者易损期预后的影响因素。方法收集2022年12月至2024年10月于安徽医科大学第一附属医院门诊及住院的263例原发性高血压合并射血分数降低的心力衰竭患者的一般资料及预后资料。所有患者在出院后3个月接受电话追踪随访,以3个月内疾病进展,包括因心力衰竭再住院、心源性死亡为随访终点。根据患者是否发生终点事件及随访左室射血分数(LVEF)情况将入组患者分为预后不良组、预后一般组及预后良好组,应用Logistic回归分析该人群易损期预后的影响因素,P<0.050为差异有统计学意义。结果(1)预后不良组患者共68例,包括心源性死亡5例,因心力衰竭再住院患者63例;预后一般组患者共174例;预后良好组21例。(2)与预后良好组相比,预后一般组中合并心房颤动、糖尿病病史患者的比例更高,C反应蛋白(CRP)、入院时脑钠肽(BNP)水平异常增高,估算的肾小球滤过率值(eGFR)显著降低(P<0.050);与预后良好组相比,预后不良组男性、有吸烟、合并心房颤动、糖尿病、慢性肾脏病病史患者的比例更高,血清白蛋白(ALB)水平、LVEF、eGFR水平显著降低,CRP水平、入院BNP水平异常增高(P<0.050);与预后一般组相比,预后不良组中男性、有吸烟、合并慢性肾脏病病史患者的比例更高,eGFR水平显著降低,入院BNP水平异常增高(P<0.050)。(3)有序多因素Logistic回归分析,结果显示患者男性(OR=1.322,95%CI:1.035~1.689)、ALB<35 g/L(OR=1.340,95%CI:1.031~1.744)、eGFR<60 mL/(min·1.73m^(2))(OR=1.644,95%CI:1.173~2.303)、入院BNP水平>1500 pg/mL(OR=1.765,95%CI:1.190~2.617)、LVEF基线值(OR=0.868,95%CI:0.778~0.969)是高血压伴射血分数降低的心力衰竭患者易损期预后的独立影响因素。结论原发性高血压合并射血分数降低的心力衰竭患者易损期拥有较高的心力衰竭再入院率及心血管死亡风险,部分患者预后良好。其中男性、ALB水平、eGFR、入院BNP水平、LVEF基线值是此类患者易损期预后的独立影响因素。 展开更多
关键词 原发性高血压 射血分数降低性心力衰竭 易损期 预后 危险因素
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血清结缔组织生长因子对2型糖尿病合并射血分数保留型心力衰竭的诊断价值研究
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作者 谢浩 朱勇 左广锋 《心肺血管病杂志》 2026年第1期33-41,共9页
目的:探讨血清结缔组织生长因子(connective tissue growth factor,CTGF/CCN2)对2型糖尿病合并射血分数保留型心力衰竭(type 2 diabetes with heart failure with preserved ejection fraction,T2DM-HFpEF)患者的诊断价值。方法:本研究... 目的:探讨血清结缔组织生长因子(connective tissue growth factor,CTGF/CCN2)对2型糖尿病合并射血分数保留型心力衰竭(type 2 diabetes with heart failure with preserved ejection fraction,T2DM-HFpEF)患者的诊断价值。方法:本研究连续入选2022年5月1日至2022年10月1日在南京医科大学附属南京医院内分泌科住院的无心力衰竭临床症状和体征的2型糖尿病(type 2 diabetes mellitus,T2DM)患者120例及T2DM-HFpEF患者120例,分别检测2组血清中CCN2、可溶性ST2(soluble ST2,sST2)及半乳糖凝集素-3(galectin-3,Gal-3)水平。人重组CCN2蛋白干预人心肌成纤维细胞(human cardiac fibroblasts,HCFs)后,采用蛋白印迹法检测HCFs胶原蛋白(Collagen)Ⅰ和CollagenⅢ的表达。结果:T2DM-HFpEF患者血清中CCN2、sST2及Gal-3水平均明显高于T2DM组(P<0.05)。血清CCN2水平与sST2(r=0.265,P<0.001)及Gal-3(r=0.411,P<0.001)呈正相关。多因素Logistic回归分析显示在校正其他临床变量后,CCN2仍为T2DM-HFpEF的独立危险因素(OR=1.41,95%CI:1.08~1.85,P=0.012)。ROC曲线分析显示CCN2水平(lnCCN2)对T2DM-HFpEF具有良好的诊断价值(AUC=0.801,95%CI:0.744~0.849,P<0.001)。NT-proBNP联合CCN2可提高其对T2DM-HFpEF的诊断效能(AUC=0.874 vs.0.833,P=0.014)。同时CCN2可以提高多因素模型的诊断价值(AUC=0.741 vs.0.640,P=0.034)。决策分析曲线显示在阈值概率0.05~0.42的区间内CCN2加入多因素模型后可提高临床净获益率,并且其在亚组分析中也体现出较好的诊断效能。人重组CCN2蛋白干预HCFs后,Collagen I及CollagenⅢ蛋白表达均显著上调(P<0.05)。结论:CCN2可以促进心肌成纤维细胞胶原蛋白分泌,其血清水平或可作为T2DM-HFpEF新的诊断标志物。 展开更多
关键词 结缔组织生长因子 射血分数保留型心力衰竭 2型糖尿病 N末端B型利钠肽前体 心肌成纤维细胞 诊断价值
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慢性心力衰竭患者发生心律失常的影响因素
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作者 刘倩文 《中国民康医学》 2026年第5期11-13,17,共4页
目的:分析慢性心力衰竭(CHF)患者发生心律失常的影响因素。方法:回顾性分析2024年1月至2025年1月该院收治的98例CHF患者的临床资料。根据是否发生心律失常将其分为发生组和未发生组。统计CHF患者心律失常的发生情况,采用Logistic回归分... 目的:分析慢性心力衰竭(CHF)患者发生心律失常的影响因素。方法:回顾性分析2024年1月至2025年1月该院收治的98例CHF患者的临床资料。根据是否发生心律失常将其分为发生组和未发生组。统计CHF患者心律失常的发生情况,采用Logistic回归分析CHF患者发生心律失常的影响因素。结果:98例CHF患者共发生心律失常32例,占32.65%(32/98);未发生心律失常66例,占67.35%(66/98);两组性别、年龄、体质量指数、文化程度、居住地、家庭平均月收入、吸烟史、饮酒史、合并高血压、合并高脂血症、合并糖尿病、CHF病程、空腹血糖(FPG)水平、总胆固醇(TC)水平、血肌酐(Scr)水平等比较,差异均无统计学意义(P>0.05);发生组美国纽约心脏病协会(NYHA)心功能分级Ⅲ~Ⅳ级、左心室射血分数(LVEF)<50%、血红蛋白(Hb)<120 g/L、心肌肌钙蛋白I(cTnI)≥0.5μg/L、B型利钠肽(BNP)≥400 pg/mL等占比均高于未发生组,差异有统计学意义(P<0.05);Logistic回归分析结果显示,NYHA心功能分级Ⅲ~Ⅳ级、LVEF<50%、Hb<120 g/L、cTnI≥0.5μg/L、BNP≥400 pg/mL等均为CHF患者发生心律失常的危险因素(OR>1,P<0.05)。结论:NYHA心功能分级Ⅲ~Ⅳ级、LVEF<50%、Hb<120 g/L、cTnI≥0.5μg/L、BNP≥400 pg/mL等均为CHF患者发生心律失常的危险因素。 展开更多
关键词 慢性心力衰竭 心律失常 影响因素 心功能分级 左心室射血分数
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射血分数保留型心力衰竭患者易损期全因再住院的危险因素及其预测模型的建立与验证
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作者 江冠颖 张丽华 +5 位作者 单秋菊 熊海燕 李岩 王珍珍 刘怡凯 孙利强 《海南医学》 2026年第4期463-470,共8页
目的探讨射血分数保留型心力衰竭(HFpEF)患者易损期全因再住院的危险因素,基于危险因素构建HFpEF患者易损期全因再住院风险预测模型,并验证模型预测效能。方法回顾性收集2022年1月至2024年12月郑州大学第二附属医院收治的182例HFpEF患... 目的探讨射血分数保留型心力衰竭(HFpEF)患者易损期全因再住院的危险因素,基于危险因素构建HFpEF患者易损期全因再住院风险预测模型,并验证模型预测效能。方法回顾性收集2022年1月至2024年12月郑州大学第二附属医院收治的182例HFpEF患者的临床资料,将其设为建模集,按照易损期再住院发生情况分为发生组(n=44)与未发生组(n=138)。对患者易损期全因再住院进行危险因素分析,基于危险因素分析结果构建列线图风险预测模型。另选取医院2024年1月至2025年9月期间收治的144例HFpEF患者作为验证集,验证该列线图风险预测模型的预测效能。结果单因素和多因素分析结果显示,氨基末端脑利钠肽前体(NT-proBNP)高(OR=1.001)、血清白蛋白低(OR=0.885)、电子健康素养量表(eHealth Literacy Scale,eHEALS)评分低(OR=0.572)、未使用可穿戴设备(OR=0.263)均为HFpEF患者易损期全因再住院的危险因素(P<0.05)。基于上述危险因素构建列线图风险预测模型,经受试者工作特征(ROC)曲线和校准曲线分析结果显示,该模型在建模集和验证集中的曲线下面积(AUC)分别为0.935(95%CI:0.893~0.978)、0.907(95%CI:0.858~0.957),决策曲线显示,预测模型具有良好的临床适用性。结论HFpEF患者易损期全因再住院的危险因素包括NT-proBNP高、血清白蛋白低、eHEALS评分低与未使用可穿戴设备,基于此构建的风险预测模型的区分度、准确性较高,预测能力较强,有助于辅助早期捕获、识别HFpEF易损期全因再住院高风险患者,为临床治疗提供参考依据。 展开更多
关键词 射血分数保留型心力衰竭 易损期 心衰再住院 危险因素 模型构建 模型验证
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