Hepatocellular carcinoma presents with three distinct immune phenotypes,including immune-desert,immune-excluded,and immune-inflamed,indicating various treatment responses and prognostic outcomes.The clinical applicati...Hepatocellular carcinoma presents with three distinct immune phenotypes,including immune-desert,immune-excluded,and immune-inflamed,indicating various treatment responses and prognostic outcomes.The clinical application of multi-omics parameters is still restricted by the expensive and less accessible assays,although they accurately reflect immune status.A comprehensive evaluation framework based on“easy-to-obtain”multi-model clinical parameters is urgently required,incorporating clinical features to establish baseline patient profiles and disease staging;routine blood tests assessing systemic metabolic and functional status;immune cell subsets quantifying subcluster dynamics;imaging features delineating tumor morphology,spatial configuration,and perilesional anatomical relationships;immunohistochemical markers positioning qualitative and quantitative detection of tumor antigens from the cellular and molecular level.This integrated phenomic approach aims to improve prognostic stratification and clinical decision-making in hepatocellular carcinoma management conveniently and practically.展开更多
Blast vibration analysis is one of the important foundations for studying the control technology of blast vibration damage. According to blast vibration live data that have been collected and the characteristics of sh...Blast vibration analysis is one of the important foundations for studying the control technology of blast vibration damage. According to blast vibration live data that have been collected and the characteristics of short-time non-stationary random signals, the wavelet packet energy spectrum analysis for blast vibration signal has made by wavelet packet analysis technology and the signals were measured under different explosion parameters （the maximal section dose, the distance of blast source to measuring point and the section number of millisecond detonator）. The results show that more than 95% frequency band energy of the signals sl-s8 concentrates at 0-200 Hz and the main vibration frequency bands of the signals sl-s8 are 70.313-125, 46.875-93.75, 15.625-93.75, 0-62.5, 42.969-125, 15.625-82.031, 7.813-62.5 and 0-62.5 Hz. Energy distributions for different frequency bands of blast vibration signal are obtained and the characteristics of energy distributions for blast vibration signal measured under different explosion parameters are analyzed. From blast vibration signal energy, the decreasing law of blast seismic waves measured under different explosion parameters was studied and the wavelet packet analysis is an effective means for studying seismic effect induced by blast.展开更多
This paper investigates the effects of charge parameters of the underwater contact explosion based on the axisymmetric smoothed particle hydrodynamics （SPH） method. The dynamic boundary particle is proposed to impro...This paper investigates the effects of charge parameters of the underwater contact explosion based on the axisymmetric smoothed particle hydrodynamics （SPH） method. The dynamic boundary particle is proposed to improve the pressure fluctuation and numerical accuracy near the symmetric axis. An in-depth study is carried out over the influence of charge shapes and detonation modes on the near-field loads in terms of the peak pressure and impulse of shock waves. For different charge shapes, the cylindrical charge with different length-diameter ratios may cause strong directivity of peak pressure and impulse in the near field. Compared with spherical charge, the peak pressure of cylindrical charge may be either weakened or enhanced in different directions. Within a certain range, the greater the length-diameter ratio is, the more obvious the effect will be. The weakened ratio near the detonation end may reach 25% approximately, while the enhanced ratio may reach around 20% in the opposite direction. However, the impulse in different directions seems to be uniform. For different detonation modes, compared with point-source explosion, the peak pressure of plane-source explosion is enhanced by about 5%. Besides, the impulse of plane-source explosion is enhanced by around 5% near the detonation end, but close to those of the point-source explosion in other directions. Based on the material constitutive relation in the axisymmetric coordinates, a simple case of underwater contact explosion is simulated to verify the above conclusions, showing that the charge parameters of underwater contact explosion should not be ignored.展开更多
The seismoacoustic analysis method has broad potential applications to source parameter estimation for near-surface explosion events such as industrial explosions and terrorist attacks.In this study,current models wer...The seismoacoustic analysis method has broad potential applications to source parameter estimation for near-surface explosion events such as industrial explosions and terrorist attacks.In this study,current models were improved by modifying the acoustic model and adopting the Bayesian Markov-chain-Monte-Carlo inversion method.The source parameters of near-surface small-yield chemical explosions were analyzed via the improved seismoacoustic analysis model and by the estimation accuracy of seismoacoustic joint inversion.Estimation and analysis results showed that the improved seismoacoustic analysis model considered ground shock coupling and the impact of explosion products ejecting from the surface so that the improved acoustic impulse relation was more consistent with the measured data than the Ford impulse relation.It is suitable for deep-burial,shallow-burial,and near-surface aerial explosions.Furthermore,trade-off relationships were declined through the application of the improved model to source parameter inversion for near-surface small-yield chemical explosions,and source parameter estimation accuracy was improved.展开更多
One of the large-scale industrial applications of Moso bamboo and poplar in China is the production of standardized fiberboard.When making fiberboard,a steam blasting pretreatment without the addition of traditional a...One of the large-scale industrial applications of Moso bamboo and poplar in China is the production of standardized fiberboard.When making fiberboard,a steam blasting pretreatment without the addition of traditional adhesives has become increasingly popular because of its environmental friendliness and wide applicability.In this study,the steam explosion pretreatment of Moso bamboo and poplar was conducted.The steam explosion pressure and holding time were varied to determine the influence of these factors on fiber quality by investigating the morphology of the fiber,the mass ratio of the unexploded specimen at the end face,the chemical composition,and the tensile strength.The following conclusions were drawn:As the steam burst pressure and holding time increased,more cellulose and hemicellulose degradation occurred(the degradation of hemicellulose was greater than that of cellulose),the lignin content rose,and the fiber bundle strength decreased.The degradation of bamboo cellulose was slightly higher than that of poplar,and the degradation of poplar hemicellulose was significantly faster than that of bamboo.Furthermore,increasing the steam explosion pressure and pressure holding time could not effectively increase the lignin content.It is recommended to use a steam blasting pressure of 2.5 MPa or 3.0 MPa and a holding time of 180 s to perform steam blasting on bamboo and poplar specimens.展开更多
A differential/integral method to estimate the kinetic parameters(apparent activation energy Eaand pre-exponential factor A) for thermal decomposition reaction of energetic materials based on Kooij formula are applied...A differential/integral method to estimate the kinetic parameters(apparent activation energy Eaand pre-exponential factor A) for thermal decomposition reaction of energetic materials based on Kooij formula are applied to study the nonisothermal decomposition reaction kinetics of hexanitrohexaazaisowurtzitane(HNIW) by analyzing nonisothermal DSC curve data. The apparent activation energy(Ea) obtained by the integral isoconversional non-isothermal method based on Kooij formula is used to check the constancy and validity of apparent activation energy by the differential/integral method based on Kooij formula. The most probable mechanism function of thermal decomposition reaction of HNIW is determined by a logical choice method. The equations for calculating the critical temperatures of thermal explosion(Tb) and adiabatic time-toexplosion(tTIad) based on Kooij formula are used to calculate the values of Tband tTIadto evaluate the thermal safety and heat-resistant ability of HNIW. All the original data needed for analyzing the kinetic parameters are from nonisothermal DSC curves. The results show that the kinetic model function in differential form and the values of Eaand A of decomposition reaction of HNIW are 3(1 a)[ ln(1 a)]2/3, 152.73 kJ mol 1and 1011.97s 1, respectively, and the values of self-accelerating decomposition temperature(TSADT), Tband tTIadare 486.55 K, 493.11 K and52.01 s, respectively.展开更多
A new numerical algorithm is presented to simulate the explosion reaction process of mine explosives based on the equation of state, the equation of mass conservation and thermodynamics balance equation of explosion p...A new numerical algorithm is presented to simulate the explosion reaction process of mine explosives based on the equation of state, the equation of mass conservation and thermodynamics balance equation of explosion products. With the affection of reversible reaction of explosion products to explosion reaction equations and thermodynamics parameters considered, the computer program has been developed. The computation values show that computer simulation results are identical with the testing ones.展开更多
Modal parameters can accurately characterize the structural dynamic properties and assess the physical state of the structure.Therefore,it is particularly significant to identify the structural modal parameters accordi...Modal parameters can accurately characterize the structural dynamic properties and assess the physical state of the structure.Therefore,it is particularly significant to identify the structural modal parameters according to the monitoring data information in the structural health monitoring(SHM)system,so as to provide a scientific basis for structural damage identification and dynamic model modification.In view of this,this paper reviews methods for identifying structural modal parameters under environmental excitation and briefly describes how to identify structural damages based on the derived modal parameters.The paper primarily introduces data-driven modal parameter recognition methods(e.g.,time-domain,frequency-domain,and time-frequency-domain methods,etc.),briefly describes damage identification methods based on the variations of modal parameters(e.g.,natural frequency,modal shapes,and curvature modal shapes,etc.)and modal validation methods(e.g.,Stability Diagram and Modal Assurance Criterion,etc.).The current status of the application of artificial intelligence(AI)methods in the direction of modal parameter recognition and damage identification is further discussed.Based on the pre-vious analysis,the main development trends of structural modal parameter recognition and damage identification methods are given to provide scientific references for the optimized design and functional upgrading of SHM systems.展开更多
In a humid environment,active metal magnesium is susceptible to the hydrogen evolution reaction with water,which significantly increases the risk of explosions in areas where magnesium is produced and used.In this pap...In a humid environment,active metal magnesium is susceptible to the hydrogen evolution reaction with water,which significantly increases the risk of explosions in areas where magnesium is produced and used.In this paper,the effects of equilibrium relative humidity(ERH) on the explosion characteristics parameters of magnesium dust under various initial conditions (concentration,particle size and temperature) were studied using a 20 L explosion device.Additionally,the explosion mechanism was thoroughly analyzed by incorporating the oxygen content results of the explosion products.The research revealed that explosion characteristics parameters (P_(max),(dp/dt)_(max)) of magnesium dust cloud initially increased and then decreased with rising ERH when the explosion system was in an“oxygen-rich”state.The maximum increments in P_(max)and (dp/dt)_(max)are 130 k Pa and 10.73 k Pa/ms,respectively.Moreover,a decrease in particle size and an increase in temperature facilitated the generation of more hydrogen from the humid magnesium dust.This phenomenon effectively improved the explosion characteristics parameters of the humid magnesium dust,thereby increasing the sensitivity and risk of the explosion system.However,in the case of a high degree of“oxygen-poor”state,the derived hydrogen instead became burdensome,resulting in an excessive amount of magnesium dust that was unavailable for reaction.This led to a decrease in the explosion characteristics parameters of humid magnesium dust,with the maximum decreases in P_(max)and (dp/dt)_(max)being 45.8 k Pa and 2.1 k Pa/ms respectively.展开更多
Researchers have achieved notable advancements over the years in exploring ship damage and stability resulting from underwater explosions(UNDEX).However,numerous challenges and open questions remain in this field.In t...Researchers have achieved notable advancements over the years in exploring ship damage and stability resulting from underwater explosions(UNDEX).However,numerous challenges and open questions remain in this field.In this study,the research progress of UNDEX load is first reviewed,which covers the explosion load during the shock wave and bubble pulsation stages.Subsequently,the research progress of ship damage caused by UNDEX is reviewed from two aspects:contact explosion and noncontact explosion.Finally,the research progress of ship navigation stability caused by UNDEX is reviewed from three aspects:natural factors,ship’s internal factors,and explosion factors.Analysis reveals that most existing research has focused on the damage to displacement ships caused by UNDEX.Meanwhile,less attention has been paid to the damage and stability of non-displacement ships caused by UNDEX,which are worthy of discussion.展开更多
Bubbles play crucial roles in various fields,including naval and ocean engineering,chemical engineering,and biochemical engineering.Numerous theoretical analyses,numerical simulations,and experimental studies have bee...Bubbles play crucial roles in various fields,including naval and ocean engineering,chemical engineering,and biochemical engineering.Numerous theoretical analyses,numerical simulations,and experimental studies have been conducted to reveal the mysteries of bubble motion and its mechanisms.These efforts have significantly advanced research in bubble dynamics,where theoretical study is an efficient method for bubble motion prediction.Since Lord Rayleigh introduced the theoretical model of single-bubble motion in incompressible fluid in 1917,theoretical studies have been pivotal in understanding bubble dynamics.This study provides a comprehensive review of the development and applicability of theoretical studies in bubble dynamics using typical theoretical bubble models across different periods as a focal point and an overview of bubble theory applications in underwater explosion,marine cavitation,and seismic exploration.This study aims to serve as a reference and catalyst for further advancements in theoretical analysis and practical applications of bubble theory across marine fields.展开更多
Gas explosion in confined space often leads to significant pressure oscillation.It is widely recognized that structural damage can be severe when the oscillation frequency of the load resonates with the natural vibrat...Gas explosion in confined space often leads to significant pressure oscillation.It is widely recognized that structural damage can be severe when the oscillation frequency of the load resonates with the natural vibration frequency of the structure.To reveal the oscillation mechanism of gas explosion load,the experiment of gas explosion was conducted in a large-scale confined tube with the length of 30 m,and the explosion process was numerically analyzed using FLACS.The results show that the essential cause of oscillation effect is the reflection of the pressure wave.In addition,due to the difference in the propagation path of the pressure wave,the load oscillation frequency at the middle position of the tunnel is twice that at the end position.The average sound velocity can be used to calculate the oscillation frequency of overpressure accurately,and the error is less than 15%.The instability of the flame surface and the increase of flame turbulence caused by the interaction between the pressure wave and the flame surface are the main contributors to the increase in overpressure and amplitude.The overpressure peaks calculated by the existing flame instability model and turbulence disturbance model are 31.7%and 34.7%lower than the numerical results,respectively.The turbulence factor model established in this work can describe the turbulence enhancement effect caused by flame instability and oscillatory load,and the difference between the theoretical and numerical results is only 4.6%.In the theoretical derivation of the overpressure model,an improved model of dynamic turbulence factor is established,which can describe the enhancement effect of turbulence factor caused by flame instability and self-turbulence.Based on the one-dimensional propagation theory of pressure wave,the oscillatory effect of the load is derived to calculate the frequency and amplitude of pressure oscillation.The average error of amplitude and frequency is less than 20%.展开更多
Unlike conventional spherical charges,a shaped charge generates not only a strong shock wave and a pulsating bubble,but also a high strain rate metal jet and a ballistic wave during the underwater explosion.They show ...Unlike conventional spherical charges,a shaped charge generates not only a strong shock wave and a pulsating bubble,but also a high strain rate metal jet and a ballistic wave during the underwater explosion.They show significant characteristic differences and couple each other.This paper designs and conducts experiments with shaped charges to analyze the complicated process.The effects of liner angle and weight of shaped charge on the characteristics of metal jets,waves,and bubbles are discussed.It is found that in underwater explosions,the shaped charge generates the metal jet accompanied by the ballistic wave.Then,the shock wave propagates and superimposes with the ballistic wave,and the generated bubble pulsates periodically.It is revealed that the maximum head velocity of the metal jet versus the liner angle a and length-to-diameter ratio k of the shaped charge follows the laws of 1/(α/180°)^(0.55)andλ^(0.16),respectively.The head shape and velocity of the metal jet determine the curvature and propagation speed of the initial ballistic wave,thus impacting the superposition time and region with the shock wave.Our findings also reveal that the metal jet carries away some explosion products,which hinders the bubble development,causing an inward depression of the bubble wall near the metal jet.Therefore,the maximum bubble radius and pulsation period are 5.2%and 3.9%smaller than the spherical charge with the same weight.In addition,the uneven axial energy distribution of the shaped charge leads to an oblique bubble jet formation.展开更多
While the moisture content of soil affects significantly the blast impulse of shallow buried explosives,the role of surface-covering water(SCW)on soil in such blast impulse remains elusive.A combined experimental and ...While the moisture content of soil affects significantly the blast impulse of shallow buried explosives,the role of surface-covering water(SCW)on soil in such blast impulse remains elusive.A combined experimental and numerical study has been carried out to characterize the effect of SCW on transferred impulse and loading magnitude of shallow buried explosives.Firstly,blast tests of shallow buried explosives were conducted,with and without the SCW,to quantitatively assess the blast loading impulse.Subsequently,finite element(FE)simulations were performed and validated against experimental measurement,with good agreement achieved.The validated FE model was then employed to predict the dynamic response of a fully-clamped metallic circular target,subjected to the explosive impact of shallow buried explosives with SCW,and explore the corresponding physical mechanisms.It was demonstrated that shallow buried explosives in saturated soil generate a greater impulse transferred towards the target relative to those in dry soil.The deformation displacement of the target plate is doubled.Increasing the height of SCW results in enhanced center peak deflection of the loaded target,accompanied by subsequent fall,due to the variation of deformation pattern of the loaded target from concentrated load to uniform load.Meanwhile,the presence of SCW increases the blast impulse transferred towards the target by three times.In addition,there exists a threshold value of the burial depth that maximizes the impact impulse.This threshold exhibits a strong sensitivity to SCW height,decreasing with increasing SCW height.An empirical formula for predicting threshold has been provided.Similar conclusions can be drawn for different explosive masses.The results provide technical guidance on blast loading intensity and its spatial distribution considering shallow buried explosives in coast-land battlefields,which can ultimately contribute to better protective designs.展开更多
To overcome the limitations of low efficiency and reliance on manual processes in the measurement of geometric parameters for bridge prefabricated components,a method based on deep learning and computer vision is deve...To overcome the limitations of low efficiency and reliance on manual processes in the measurement of geometric parameters for bridge prefabricated components,a method based on deep learning and computer vision is developed to identify the geometric parameters.The study utilizes a common precast element for highway bridges as the research subject.First,edge feature points of the bridge component section are extracted from images of the precast component cross-sections by combining the Canny operator with mathematical morphology.Subsequently,a deep learning model is developed to identify the geometric parameters of the precast components using the extracted edge coordinates from the images as input and the predefined control parameters of the bridge section as output.A dataset is generated by varying the control parameters and noise levels for model training.Finally,field measurements are conducted to validate the accuracy of the developed method.The results indicate that the developed method effectively identifies the geometric parameters of bridge precast components,with an error rate maintained within 5%.展开更多
The afterburning of TNT and structural constraints in confined spaces significantly amplify the blast load,leading to severe structural damage. This study investigates the mechanisms underlying the enhanced dynamic re...The afterburning of TNT and structural constraints in confined spaces significantly amplify the blast load,leading to severe structural damage. This study investigates the mechanisms underlying the enhanced dynamic response of reinforced concrete blast doors with four-sided restraints in confined space. Explosion tests with TNT charges ranging from 0.15 kg to 0.4 kg were conducted in a confined space,capturing overpressure loads and the dynamic response of the blast door. An internal explosion model incorporating the afterburning effect was developed using LS-DYNA software and validated against experimental data. The results reveal that the TNT afterburning effect amplifies both the initial peak overpressure and the quasi-static overpressure, resulting in increased deformation of the blast door.Within the 0.15-0.4 kg charge range, the initial overpressure peak and quasi-static overpressure increased by an average of 1.79 times and 2.21 times, respectively. Additionally, the afterburning effect enhanced the blast door's deflection by 177%. Compared to open-space scenarios, the cumulative deflection of the blast door due to repeated shock wave impacts is significantly greater in confined spaces. Furthermore, the quasi-static pressure arising from the structural constraints sustains the blast door's deflection at a high level.展开更多
Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in c...Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate models.Previous studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC simulations.In this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its collapse.Through a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s variability.The traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of AMOC.The results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter slowly.However,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale.展开更多
The seismic data of the Laoshan Uplift in the South Yellow Sea Basin reveal a low signal-tonoise ratio and low refl ection signal energy in the deep Mesozoic–Paleozoic strata.The main reason is that the Mesozoic-Pale...The seismic data of the Laoshan Uplift in the South Yellow Sea Basin reveal a low signal-tonoise ratio and low refl ection signal energy in the deep Mesozoic–Paleozoic strata.The main reason is that the Mesozoic-Paleozoic marine carbonate rock strata are directly covered by the Cenozoic terrestrial clastic rock strata,which form a strong shielding layer.To obtain the reflection signals of the strata below the strong shielding layer,a one-way wave equation bidirectional illumination analysis of the main observation system parameters was conducted by analyzing the mechanism of the strong shielding layer.Low-frequency seismic sources are assumed to have a high illumination intensity on the reflection layer below the strong shielding layer.Accordingly,optimized acquisition parameter suggestions were proposed,and reacquisition was performed at the existing survey line locations in the Laoshan Uplift area.The imaging of the newly acquired data in the middle and deep layers was drastically improved.It revealed the unconformity between the Sinian and Cambrian under the strong shielding layer.The study yielded new insights into the tectonic and sedimentary evolution of the Lower Paleozoic in the South Yellow Sea.展开更多
A conceptual model of intermittent joints is introduced to the cyclic shear test in the laboratory to explore the effects of loading parameters on its shear behavior under cyclic shear loading.The results show that th...A conceptual model of intermittent joints is introduced to the cyclic shear test in the laboratory to explore the effects of loading parameters on its shear behavior under cyclic shear loading.The results show that the loading parameters(initial normal stress,normal stiffness,and shear velocity)determine propagation paths of the wing and secondary cracks in rock bridges during the initial shear cycle,creating different morphologies of macroscopic step-path rupture surfaces and asperities on them.The differences in stress state and rupture surface induce different cyclic shear responses.It shows that high initial normal stress accelerates asperity degradation,raises shear resistance,and promotes compression of intermittent joints.In addition,high normal stiffness provides higher normal stress and shear resistance during the initial cycles and inhibits the dilation and compression of intermittent joints.High shear velocity results in a higher shear resistance,greater dilation,and greater compression.Finally,shear strength is most sensitive to initial normal stress,followed by shear velocity and normal stiffness.Moreover,average dilation angle is most sensitive to initial normal stress,followed by normal stiffness and shear velocity.During the shear cycles,frictional coefficient is affected by asperity degradation,backfilling of rock debris,and frictional area,exhibiting a non-monotonic behavior.展开更多
The concept of TNT(Trinitrotoluene,C_7H_5N_3O_6)equivalence is often invoked to evaluate the performance and predict the explosion parameters of different types of explosives.However,due to its low prediction accuracy...The concept of TNT(Trinitrotoluene,C_7H_5N_3O_6)equivalence is often invoked to evaluate the performance and predict the explosion parameters of different types of explosives.However,due to its low prediction accuracy and limited application range,the use of TNT equivalence for predicting explosion parameters in a confined space is rare.Compared with explosions in free fields,the process of explosive energy release in a confined space is closely related to various factors such as oxygen balance,combustible components content,and surrounding oxygen content.Studies have shown that in a confined space,negative oxygen balance explosives react with surrounding oxygen during afterburning,resulting in additional energy release and enhanced blast effects.The mechanism of energy release during afterburning is highly complex,making it challenging to determine the TNT equivalence for blast effects in a confined space.Therefore,this remains an active area of research.In this study,internal blast experiments were conducted using TNT and three other explosives under both air and N_2(Nitrogen)conditions to obtain explosion parameters including blast wave overpressure,quasi-static pressure,and temperature.The influences of oxygen balance and external oxygen content on energy release are analyzed.The author proposes principles for determining TNT equivalence for internal explosions while verifying the accuracy of obtained blast parameters through calculations based on TNT equivalence.These findings can serve as references for predicting blast performance.展开更多
文摘Hepatocellular carcinoma presents with three distinct immune phenotypes,including immune-desert,immune-excluded,and immune-inflamed,indicating various treatment responses and prognostic outcomes.The clinical application of multi-omics parameters is still restricted by the expensive and less accessible assays,although they accurately reflect immune status.A comprehensive evaluation framework based on“easy-to-obtain”multi-model clinical parameters is urgently required,incorporating clinical features to establish baseline patient profiles and disease staging;routine blood tests assessing systemic metabolic and functional status;immune cell subsets quantifying subcluster dynamics;imaging features delineating tumor morphology,spatial configuration,and perilesional anatomical relationships;immunohistochemical markers positioning qualitative and quantitative detection of tumor antigens from the cellular and molecular level.This integrated phenomic approach aims to improve prognostic stratification and clinical decision-making in hepatocellular carcinoma management conveniently and practically.
基金Foundation item: Project(51064009) supported by the National Natural Science Foundation of ChinaProject(201104356) supported by the China Postdoctoral Science FoundationProject(20114BAB206030) supported by the Natural Science Foundation of Jiangxi Province,China
文摘Blast vibration analysis is one of the important foundations for studying the control technology of blast vibration damage. According to blast vibration live data that have been collected and the characteristics of short-time non-stationary random signals, the wavelet packet energy spectrum analysis for blast vibration signal has made by wavelet packet analysis technology and the signals were measured under different explosion parameters （the maximal section dose, the distance of blast source to measuring point and the section number of millisecond detonator）. The results show that more than 95% frequency band energy of the signals sl-s8 concentrates at 0-200 Hz and the main vibration frequency bands of the signals sl-s8 are 70.313-125, 46.875-93.75, 15.625-93.75, 0-62.5, 42.969-125, 15.625-82.031, 7.813-62.5 and 0-62.5 Hz. Energy distributions for different frequency bands of blast vibration signal are obtained and the characteristics of energy distributions for blast vibration signal measured under different explosion parameters are analyzed. From blast vibration signal energy, the decreasing law of blast seismic waves measured under different explosion parameters was studied and the wavelet packet analysis is an effective means for studying seismic effect induced by blast.
基金supported by the National Natural Science Foundation of China(No.51379039)the Excellent Young Scientists Fund(No.51222904)
文摘This paper investigates the effects of charge parameters of the underwater contact explosion based on the axisymmetric smoothed particle hydrodynamics （SPH） method. The dynamic boundary particle is proposed to improve the pressure fluctuation and numerical accuracy near the symmetric axis. An in-depth study is carried out over the influence of charge shapes and detonation modes on the near-field loads in terms of the peak pressure and impulse of shock waves. For different charge shapes, the cylindrical charge with different length-diameter ratios may cause strong directivity of peak pressure and impulse in the near field. Compared with spherical charge, the peak pressure of cylindrical charge may be either weakened or enhanced in different directions. Within a certain range, the greater the length-diameter ratio is, the more obvious the effect will be. The weakened ratio near the detonation end may reach 25% approximately, while the enhanced ratio may reach around 20% in the opposite direction. However, the impulse in different directions seems to be uniform. For different detonation modes, compared with point-source explosion, the peak pressure of plane-source explosion is enhanced by about 5%. Besides, the impulse of plane-source explosion is enhanced by around 5% near the detonation end, but close to those of the point-source explosion in other directions. Based on the material constitutive relation in the axisymmetric coordinates, a simple case of underwater contact explosion is simulated to verify the above conclusions, showing that the charge parameters of underwater contact explosion should not be ignored.
基金the National Natural Science Foundation of China(No.12072290).
文摘The seismoacoustic analysis method has broad potential applications to source parameter estimation for near-surface explosion events such as industrial explosions and terrorist attacks.In this study,current models were improved by modifying the acoustic model and adopting the Bayesian Markov-chain-Monte-Carlo inversion method.The source parameters of near-surface small-yield chemical explosions were analyzed via the improved seismoacoustic analysis model and by the estimation accuracy of seismoacoustic joint inversion.Estimation and analysis results showed that the improved seismoacoustic analysis model considered ground shock coupling and the impact of explosion products ejecting from the surface so that the improved acoustic impulse relation was more consistent with the measured data than the Ford impulse relation.It is suitable for deep-burial,shallow-burial,and near-surface aerial explosions.Furthermore,trade-off relationships were declined through the application of the improved model to source parameter inversion for near-surface small-yield chemical explosions,and source parameter estimation accuracy was improved.
基金We thank Jiangsu Province High-level Talent Selection Training(JNHB-127)the National Key R&D Program of China(2017YFC0703501)+5 种基金the National Natural Science Foundation of China(51878590)Jiangsu Provincial Department of Housing and construction(2018ZD117 and 2019ZD092)the Natural Science Foundation of Jiangsu Province(Grant Nos.BK20170926 and BK20150878)the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(Grant No.19KJD220002)the Yangzhou Science and Technology Project(YZ2019047)College Research Project(2019xjzk014)for their funding.
文摘One of the large-scale industrial applications of Moso bamboo and poplar in China is the production of standardized fiberboard.When making fiberboard,a steam blasting pretreatment without the addition of traditional adhesives has become increasingly popular because of its environmental friendliness and wide applicability.In this study,the steam explosion pretreatment of Moso bamboo and poplar was conducted.The steam explosion pressure and holding time were varied to determine the influence of these factors on fiber quality by investigating the morphology of the fiber,the mass ratio of the unexploded specimen at the end face,the chemical composition,and the tensile strength.The following conclusions were drawn:As the steam burst pressure and holding time increased,more cellulose and hemicellulose degradation occurred(the degradation of hemicellulose was greater than that of cellulose),the lignin content rose,and the fiber bundle strength decreased.The degradation of bamboo cellulose was slightly higher than that of poplar,and the degradation of poplar hemicellulose was significantly faster than that of bamboo.Furthermore,increasing the steam explosion pressure and pressure holding time could not effectively increase the lignin content.It is recommended to use a steam blasting pressure of 2.5 MPa or 3.0 MPa and a holding time of 180 s to perform steam blasting on bamboo and poplar specimens.
文摘A differential/integral method to estimate the kinetic parameters(apparent activation energy Eaand pre-exponential factor A) for thermal decomposition reaction of energetic materials based on Kooij formula are applied to study the nonisothermal decomposition reaction kinetics of hexanitrohexaazaisowurtzitane(HNIW) by analyzing nonisothermal DSC curve data. The apparent activation energy(Ea) obtained by the integral isoconversional non-isothermal method based on Kooij formula is used to check the constancy and validity of apparent activation energy by the differential/integral method based on Kooij formula. The most probable mechanism function of thermal decomposition reaction of HNIW is determined by a logical choice method. The equations for calculating the critical temperatures of thermal explosion(Tb) and adiabatic time-toexplosion(tTIad) based on Kooij formula are used to calculate the values of Tband tTIadto evaluate the thermal safety and heat-resistant ability of HNIW. All the original data needed for analyzing the kinetic parameters are from nonisothermal DSC curves. The results show that the kinetic model function in differential form and the values of Eaand A of decomposition reaction of HNIW are 3(1 a)[ ln(1 a)]2/3, 152.73 kJ mol 1and 1011.97s 1, respectively, and the values of self-accelerating decomposition temperature(TSADT), Tband tTIadare 486.55 K, 493.11 K and52.01 s, respectively.
文摘A new numerical algorithm is presented to simulate the explosion reaction process of mine explosives based on the equation of state, the equation of mass conservation and thermodynamics balance equation of explosion products. With the affection of reversible reaction of explosion products to explosion reaction equations and thermodynamics parameters considered, the computer program has been developed. The computation values show that computer simulation results are identical with the testing ones.
基金supported by the Innovation Foundation of Provincial Education Department of Gansu(2024B-005)the Gansu Province National Science Foundation(22YF7GA182)the Fundamental Research Funds for the Central Universities(No.lzujbky2022-kb01)。
文摘Modal parameters can accurately characterize the structural dynamic properties and assess the physical state of the structure.Therefore,it is particularly significant to identify the structural modal parameters according to the monitoring data information in the structural health monitoring(SHM)system,so as to provide a scientific basis for structural damage identification and dynamic model modification.In view of this,this paper reviews methods for identifying structural modal parameters under environmental excitation and briefly describes how to identify structural damages based on the derived modal parameters.The paper primarily introduces data-driven modal parameter recognition methods(e.g.,time-domain,frequency-domain,and time-frequency-domain methods,etc.),briefly describes damage identification methods based on the variations of modal parameters(e.g.,natural frequency,modal shapes,and curvature modal shapes,etc.)and modal validation methods(e.g.,Stability Diagram and Modal Assurance Criterion,etc.).The current status of the application of artificial intelligence(AI)methods in the direction of modal parameter recognition and damage identification is further discussed.Based on the pre-vious analysis,the main development trends of structural modal parameter recognition and damage identification methods are given to provide scientific references for the optimized design and functional upgrading of SHM systems.
基金financial support of the China Postdoctoral Science Foundation (2022M721631)Key Laboratory of Safety Engineering and Technology Research of Zhejiang Province (No. 202307)+1 种基金Jiangsu Natural Science Foundation (SBK2023042272)Jiangsu Funding Program for Excellent Postdoctoral Talent (No. 2023827)。
文摘In a humid environment,active metal magnesium is susceptible to the hydrogen evolution reaction with water,which significantly increases the risk of explosions in areas where magnesium is produced and used.In this paper,the effects of equilibrium relative humidity(ERH) on the explosion characteristics parameters of magnesium dust under various initial conditions (concentration,particle size and temperature) were studied using a 20 L explosion device.Additionally,the explosion mechanism was thoroughly analyzed by incorporating the oxygen content results of the explosion products.The research revealed that explosion characteristics parameters (P_(max),(dp/dt)_(max)) of magnesium dust cloud initially increased and then decreased with rising ERH when the explosion system was in an“oxygen-rich”state.The maximum increments in P_(max)and (dp/dt)_(max)are 130 k Pa and 10.73 k Pa/ms,respectively.Moreover,a decrease in particle size and an increase in temperature facilitated the generation of more hydrogen from the humid magnesium dust.This phenomenon effectively improved the explosion characteristics parameters of the humid magnesium dust,thereby increasing the sensitivity and risk of the explosion system.However,in the case of a high degree of“oxygen-poor”state,the derived hydrogen instead became burdensome,resulting in an excessive amount of magnesium dust that was unavailable for reaction.This led to a decrease in the explosion characteristics parameters of humid magnesium dust,with the maximum decreases in P_(max)and (dp/dt)_(max)being 45.8 k Pa and 2.1 k Pa/ms respectively.
基金Supported by the Key R&D Program of Heilongjiang Province(Grant No.JD22A024)the Science Fund for Excellent Youth Foundation of Heilongjiang Province of China(Grant No.YQ2021E010).
文摘Researchers have achieved notable advancements over the years in exploring ship damage and stability resulting from underwater explosions(UNDEX).However,numerous challenges and open questions remain in this field.In this study,the research progress of UNDEX load is first reviewed,which covers the explosion load during the shock wave and bubble pulsation stages.Subsequently,the research progress of ship damage caused by UNDEX is reviewed from two aspects:contact explosion and noncontact explosion.Finally,the research progress of ship navigation stability caused by UNDEX is reviewed from three aspects:natural factors,ship’s internal factors,and explosion factors.Analysis reveals that most existing research has focused on the damage to displacement ships caused by UNDEX.Meanwhile,less attention has been paid to the damage and stability of non-displacement ships caused by UNDEX,which are worthy of discussion.
文摘Bubbles play crucial roles in various fields,including naval and ocean engineering,chemical engineering,and biochemical engineering.Numerous theoretical analyses,numerical simulations,and experimental studies have been conducted to reveal the mysteries of bubble motion and its mechanisms.These efforts have significantly advanced research in bubble dynamics,where theoretical study is an efficient method for bubble motion prediction.Since Lord Rayleigh introduced the theoretical model of single-bubble motion in incompressible fluid in 1917,theoretical studies have been pivotal in understanding bubble dynamics.This study provides a comprehensive review of the development and applicability of theoretical studies in bubble dynamics using typical theoretical bubble models across different periods as a focal point and an overview of bubble theory applications in underwater explosion,marine cavitation,and seismic exploration.This study aims to serve as a reference and catalyst for further advancements in theoretical analysis and practical applications of bubble theory across marine fields.
基金financial support from National Natural Science Foundation of China(Grant No.52378488)Postgraduate Research&Practice Innovation Program of Jiangsu Province(Grant No.KYCX22_0222).
文摘Gas explosion in confined space often leads to significant pressure oscillation.It is widely recognized that structural damage can be severe when the oscillation frequency of the load resonates with the natural vibration frequency of the structure.To reveal the oscillation mechanism of gas explosion load,the experiment of gas explosion was conducted in a large-scale confined tube with the length of 30 m,and the explosion process was numerically analyzed using FLACS.The results show that the essential cause of oscillation effect is the reflection of the pressure wave.In addition,due to the difference in the propagation path of the pressure wave,the load oscillation frequency at the middle position of the tunnel is twice that at the end position.The average sound velocity can be used to calculate the oscillation frequency of overpressure accurately,and the error is less than 15%.The instability of the flame surface and the increase of flame turbulence caused by the interaction between the pressure wave and the flame surface are the main contributors to the increase in overpressure and amplitude.The overpressure peaks calculated by the existing flame instability model and turbulence disturbance model are 31.7%and 34.7%lower than the numerical results,respectively.The turbulence factor model established in this work can describe the turbulence enhancement effect caused by flame instability and oscillatory load,and the difference between the theoretical and numerical results is only 4.6%.In the theoretical derivation of the overpressure model,an improved model of dynamic turbulence factor is established,which can describe the enhancement effect of turbulence factor caused by flame instability and self-turbulence.Based on the one-dimensional propagation theory of pressure wave,the oscillatory effect of the load is derived to calculate the frequency and amplitude of pressure oscillation.The average error of amplitude and frequency is less than 20%.
基金funded by the National Natural Science Founda-tion of China(52071109).
文摘Unlike conventional spherical charges,a shaped charge generates not only a strong shock wave and a pulsating bubble,but also a high strain rate metal jet and a ballistic wave during the underwater explosion.They show significant characteristic differences and couple each other.This paper designs and conducts experiments with shaped charges to analyze the complicated process.The effects of liner angle and weight of shaped charge on the characteristics of metal jets,waves,and bubbles are discussed.It is found that in underwater explosions,the shaped charge generates the metal jet accompanied by the ballistic wave.Then,the shock wave propagates and superimposes with the ballistic wave,and the generated bubble pulsates periodically.It is revealed that the maximum head velocity of the metal jet versus the liner angle a and length-to-diameter ratio k of the shaped charge follows the laws of 1/(α/180°)^(0.55)andλ^(0.16),respectively.The head shape and velocity of the metal jet determine the curvature and propagation speed of the initial ballistic wave,thus impacting the superposition time and region with the shock wave.Our findings also reveal that the metal jet carries away some explosion products,which hinders the bubble development,causing an inward depression of the bubble wall near the metal jet.Therefore,the maximum bubble radius and pulsation period are 5.2%and 3.9%smaller than the spherical charge with the same weight.In addition,the uneven axial energy distribution of the shaped charge leads to an oblique bubble jet formation.
基金supported by the National Natural Science Foundation of China(Grant Nos.12002156,11972185,12372136)Research Fund of State Key Laboratory of Mechanics and Control for Aerospace Structures(Grant No.MCMS-I-0222K01)。
文摘While the moisture content of soil affects significantly the blast impulse of shallow buried explosives,the role of surface-covering water(SCW)on soil in such blast impulse remains elusive.A combined experimental and numerical study has been carried out to characterize the effect of SCW on transferred impulse and loading magnitude of shallow buried explosives.Firstly,blast tests of shallow buried explosives were conducted,with and without the SCW,to quantitatively assess the blast loading impulse.Subsequently,finite element(FE)simulations were performed and validated against experimental measurement,with good agreement achieved.The validated FE model was then employed to predict the dynamic response of a fully-clamped metallic circular target,subjected to the explosive impact of shallow buried explosives with SCW,and explore the corresponding physical mechanisms.It was demonstrated that shallow buried explosives in saturated soil generate a greater impulse transferred towards the target relative to those in dry soil.The deformation displacement of the target plate is doubled.Increasing the height of SCW results in enhanced center peak deflection of the loaded target,accompanied by subsequent fall,due to the variation of deformation pattern of the loaded target from concentrated load to uniform load.Meanwhile,the presence of SCW increases the blast impulse transferred towards the target by three times.In addition,there exists a threshold value of the burial depth that maximizes the impact impulse.This threshold exhibits a strong sensitivity to SCW height,decreasing with increasing SCW height.An empirical formula for predicting threshold has been provided.Similar conclusions can be drawn for different explosive masses.The results provide technical guidance on blast loading intensity and its spatial distribution considering shallow buried explosives in coast-land battlefields,which can ultimately contribute to better protective designs.
基金The National Natural Science Foundation of China(No.52338011,52378291)Young Elite Scientists Sponsorship Program by CAST(No.2022-2024QNRC0101).
文摘To overcome the limitations of low efficiency and reliance on manual processes in the measurement of geometric parameters for bridge prefabricated components,a method based on deep learning and computer vision is developed to identify the geometric parameters.The study utilizes a common precast element for highway bridges as the research subject.First,edge feature points of the bridge component section are extracted from images of the precast component cross-sections by combining the Canny operator with mathematical morphology.Subsequently,a deep learning model is developed to identify the geometric parameters of the precast components using the extracted edge coordinates from the images as input and the predefined control parameters of the bridge section as output.A dataset is generated by varying the control parameters and noise levels for model training.Finally,field measurements are conducted to validate the accuracy of the developed method.The results indicate that the developed method effectively identifies the geometric parameters of bridge precast components,with an error rate maintained within 5%.
基金financially supported by the National Natural Science Foundation of China (Grant No. 52278504)the Natural Science Foundation of Jiangsu Province (Grant No. BK20220141)。
文摘The afterburning of TNT and structural constraints in confined spaces significantly amplify the blast load,leading to severe structural damage. This study investigates the mechanisms underlying the enhanced dynamic response of reinforced concrete blast doors with four-sided restraints in confined space. Explosion tests with TNT charges ranging from 0.15 kg to 0.4 kg were conducted in a confined space,capturing overpressure loads and the dynamic response of the blast door. An internal explosion model incorporating the afterburning effect was developed using LS-DYNA software and validated against experimental data. The results reveal that the TNT afterburning effect amplifies both the initial peak overpressure and the quasi-static overpressure, resulting in increased deformation of the blast door.Within the 0.15-0.4 kg charge range, the initial overpressure peak and quasi-static overpressure increased by an average of 1.79 times and 2.21 times, respectively. Additionally, the afterburning effect enhanced the blast door's deflection by 177%. Compared to open-space scenarios, the cumulative deflection of the blast door due to repeated shock wave impacts is significantly greater in confined spaces. Furthermore, the quasi-static pressure arising from the structural constraints sustains the blast door's deflection at a high level.
基金supported by the National Key R&D Program of China [grant number 2023YFF0805202]the National Natural Science Foun-dation of China [grant number 42175045]the Strategic Priority Research Program of the Chinese Academy of Sciences [grant number XDB42000000]。
文摘Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate models.Previous studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC simulations.In this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its collapse.Through a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s variability.The traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of AMOC.The results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter slowly.However,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale.
基金“High precision prestack reverse time depth migration imaging of long array seismic data in the East China Sea Shelf Basin”of the National Natural Science Foundation of China(No.42106207)“Seismic acquisition technology for deep strata under strong shielding layers in the sea and rugged seabed”of Laoshan Laboratory Science and Technology Innovation Project(No.LSKJ202203404)“Research on the compensation methods of the middledeep weak seismic reflections in the South Yellow Sea based on multi-resolution HHT time-frequency analysis”of the National Natural Science Foundation of China(No.42106208).
文摘The seismic data of the Laoshan Uplift in the South Yellow Sea Basin reveal a low signal-tonoise ratio and low refl ection signal energy in the deep Mesozoic–Paleozoic strata.The main reason is that the Mesozoic-Paleozoic marine carbonate rock strata are directly covered by the Cenozoic terrestrial clastic rock strata,which form a strong shielding layer.To obtain the reflection signals of the strata below the strong shielding layer,a one-way wave equation bidirectional illumination analysis of the main observation system parameters was conducted by analyzing the mechanism of the strong shielding layer.Low-frequency seismic sources are assumed to have a high illumination intensity on the reflection layer below the strong shielding layer.Accordingly,optimized acquisition parameter suggestions were proposed,and reacquisition was performed at the existing survey line locations in the Laoshan Uplift area.The imaging of the newly acquired data in the middle and deep layers was drastically improved.It revealed the unconformity between the Sinian and Cambrian under the strong shielding layer.The study yielded new insights into the tectonic and sedimentary evolution of the Lower Paleozoic in the South Yellow Sea.
基金financially supported by the National Natural Science Foundation of China(Grant No.42172292)Taishan Scholars Project Special Funding,and Shandong Energy Group(Grant No.SNKJ 2022A01-R26).
文摘A conceptual model of intermittent joints is introduced to the cyclic shear test in the laboratory to explore the effects of loading parameters on its shear behavior under cyclic shear loading.The results show that the loading parameters(initial normal stress,normal stiffness,and shear velocity)determine propagation paths of the wing and secondary cracks in rock bridges during the initial shear cycle,creating different morphologies of macroscopic step-path rupture surfaces and asperities on them.The differences in stress state and rupture surface induce different cyclic shear responses.It shows that high initial normal stress accelerates asperity degradation,raises shear resistance,and promotes compression of intermittent joints.In addition,high normal stiffness provides higher normal stress and shear resistance during the initial cycles and inhibits the dilation and compression of intermittent joints.High shear velocity results in a higher shear resistance,greater dilation,and greater compression.Finally,shear strength is most sensitive to initial normal stress,followed by shear velocity and normal stiffness.Moreover,average dilation angle is most sensitive to initial normal stress,followed by normal stiffness and shear velocity.During the shear cycles,frictional coefficient is affected by asperity degradation,backfilling of rock debris,and frictional area,exhibiting a non-monotonic behavior.
文摘The concept of TNT(Trinitrotoluene,C_7H_5N_3O_6)equivalence is often invoked to evaluate the performance and predict the explosion parameters of different types of explosives.However,due to its low prediction accuracy and limited application range,the use of TNT equivalence for predicting explosion parameters in a confined space is rare.Compared with explosions in free fields,the process of explosive energy release in a confined space is closely related to various factors such as oxygen balance,combustible components content,and surrounding oxygen content.Studies have shown that in a confined space,negative oxygen balance explosives react with surrounding oxygen during afterburning,resulting in additional energy release and enhanced blast effects.The mechanism of energy release during afterburning is highly complex,making it challenging to determine the TNT equivalence for blast effects in a confined space.Therefore,this remains an active area of research.In this study,internal blast experiments were conducted using TNT and three other explosives under both air and N_2(Nitrogen)conditions to obtain explosion parameters including blast wave overpressure,quasi-static pressure,and temperature.The influences of oxygen balance and external oxygen content on energy release are analyzed.The author proposes principles for determining TNT equivalence for internal explosions while verifying the accuracy of obtained blast parameters through calculations based on TNT equivalence.These findings can serve as references for predicting blast performance.
