Experimental therapies targeting immune and stromal cells,such as mast cells,cancer-associated fibroblasts,dendritic cells,and tumor endothelial cells,in the treatment of gastrointestinal solid tumors pose new and com...Experimental therapies targeting immune and stromal cells,such as mast cells,cancer-associated fibroblasts,dendritic cells,and tumor endothelial cells,in the treatment of gastrointestinal solid tumors pose new and complex surgical and medico-legal challenges.These innovative treatments require that informed consent not be limited to simple acceptance of the medical procedure,but instead reflect a true relational and cognitive process grounded in understanding,free choice,and the ability to revoke consent at any time.In particular,it is essential that the patient understands the experimental nature of the therapy,its development stage,potential benefits and risks,as well as the implications for their health and personal dignity.In the case of stromal cell-based treatments,which may exert complex immunomodulatory effects or activate angiogenic pathways that are not yet fully understood,patients must be made fully aware that they are participating in a non-standardized therapy whose outcomes,whether beneficial or harmful,cannot yet be predicted with certainty.This requires particularly careful medical communication,using simple yet scientifically accurate explanations delivered in appropriate language,along with a final verification of the patient’s actual understanding.展开更多
Currently,the number of patients with myopia is increasing rapidly across the globe.Traditional Chinese medicine(TCM),with its long history and rich experience,has shown promise in effectively managing and treating th...Currently,the number of patients with myopia is increasing rapidly across the globe.Traditional Chinese medicine(TCM),with its long history and rich experience,has shown promise in effectively managing and treating this condition.Nevertheless,considering the vast amount of research that is currently being conducted,focusing on the utilization of TCM in the management of myopia,there is an urgent requirement for a thorough and comprehensive review.The review would serve to clarify the practical applications of TCM within this specific field,and it would also aim to elucidate the underlying mechanisms that are at play,providing a deeper understanding of how TCM principles can be effectively integrated into modern medical practices.Here,some modern medical pathogenesis of myopia and appropriate TCM techniques studies are summarized in the prevention and treatment of myopia.Further,we discussed the potential mechanisms and the future research directions of TCM against myopia.Identifying these mechanisms is crucial for understanding how TCM can be effectively utilized in this context.The combination of various TCM methods or the combination of traditional Chinese and Western medicine is of great significance for the prevention and control of myopia in the future.展开更多
With the increasing emphasis on personal information protection,encryption through security protocols has emerged as a critical requirement in data transmission and reception processes.Nevertheless,IoT ecosystems comp...With the increasing emphasis on personal information protection,encryption through security protocols has emerged as a critical requirement in data transmission and reception processes.Nevertheless,IoT ecosystems comprise heterogeneous networks where outdated systems coexist with the latest devices,spanning a range of devices from non-encrypted ones to fully encrypted ones.Given the limited visibility into payloads in this context,this study investigates AI-based attack detection methods that leverage encrypted traffic metadata,eliminating the need for decryption and minimizing system performance degradation—especially in light of these heterogeneous devices.Using the UNSW-NB15 and CICIoT-2023 dataset,encrypted and unencrypted traffic were categorized according to security protocol,and AI-based intrusion detection experiments were conducted for each traffic type based on metadata.To mitigate the problem of class imbalance,eight different data sampling techniques were applied.The effectiveness of these sampling techniques was then comparatively analyzed using two ensemble models and three Deep Learning(DL)models from various perspectives.The experimental results confirmed that metadata-based attack detection is feasible using only encrypted traffic.In the UNSW-NB15 dataset,the f1-score of encrypted traffic was approximately 0.98,which is 4.3%higher than that of unencrypted traffic(approximately 0.94).In addition,analysis of the encrypted traffic in the CICIoT-2023 dataset using the same method showed a significantly lower f1-score of roughly 0.43,indicating that the quality of the dataset and the preprocessing approach have a substantial impact on detection performance.Furthermore,when data sampling techniques were applied to encrypted traffic,the recall in the UNSWNB15(Encrypted)dataset improved by up to 23.0%,and in the CICIoT-2023(Encrypted)dataset by 20.26%,showing a similar level of improvement.Notably,in CICIoT-2023,f1-score and Receiver Operation Characteristic-Area Under the Curve(ROC-AUC)increased by 59.0%and 55.94%,respectively.These results suggest that data sampling can have a positive effect even in encrypted environments.However,the extent of the improvement may vary depending on data quality,model architecture,and sampling strategy.展开更多
Synaptic pruning is a crucial process in synaptic refinement,eliminating unstable synaptic connections in neural circuits.This process is triggered and regulated primarily by spontaneous neural activity and experience...Synaptic pruning is a crucial process in synaptic refinement,eliminating unstable synaptic connections in neural circuits.This process is triggered and regulated primarily by spontaneous neural activity and experience-dependent mechanisms.The pruning process involves multiple molecular signals and a series of regulatory activities governing the“eat me”and“don't eat me”states.Under physiological conditions,the interaction between glial cells and neurons results in the clearance of unnecessary synapses,maintaining normal neural circuit functionality via synaptic pruning.Alterations in genetic and environmental factors can lead to imbalanced synaptic pruning,thus promoting the occurrence and development of autism spectrum disorder,schizophrenia,Alzheimer's disease,and other neurological disorders.In this review,we investigated the molecular mechanisms responsible for synaptic pruning during neural development.We focus on how synaptic pruning can regulate neural circuits and its association with neurological disorders.Furthermore,we discuss the application of emerging optical and imaging technologies to observe synaptic structure and function,as well as their potential for clinical translation.Our aim was to enhance our understanding of synaptic pruning during neural development,including the molecular basis underlying the regulation of synaptic function and the dynamic changes in synaptic density,and to investigate the potential role of these mechanisms in the pathophysiology of neurological diseases,thus providing a theoretical foundation for the treatment of neurological disorders.展开更多
THE Nanjing Yunjin brocade,known for its stunning luster,exquisite patterns,and a wealth of shades,represents the highest level of Chinese brocade craftsmanship.It was the designated textile for the imperial courts of...THE Nanjing Yunjin brocade,known for its stunning luster,exquisite patterns,and a wealth of shades,represents the highest level of Chinese brocade craftsmanship.It was the designated textile for the imperial courts of the Yuan(1206-1368),Ming(1368-1644),and Qing(1616-1911)dynasties,and is still highly regarded to this day.展开更多
Based on loading-unloading test, tensile impact recovery experimental techniques have been developed to obtain the isothermal stress-strain curves of materials under high strain rates. The thermal softening effect can...Based on loading-unloading test, tensile impact recovery experimental techniques have been developed to obtain the isothermal stress-strain curves of materials under high strain rates. The thermal softening effect can be decoupled by comparing the isothermal stress-strain curves with the adiabatic stress-strain curves at the same strain rate. In the present paper, recovery experiments of brass have been carried out on a self-designed rotating disk tensile impact apparatus. According to the parabolic strain hardening power-law thermo-viscoplastic constitutive model, strain hardening parameter, strain rates strengthening parameter and thermal softening synthetical parameter have been decoupled from experimental results. Furthermore, from these parameters, one can determine the theoretical isothermal curves and adiabatic curves at high strain rates well-coinciding the experimental results respectively. It indicates that the recovery experimental techniques of tensile impact are effective and reliable and are important means for the study of thermo-mechanical coupling. The experimental results also reveals that brass is a typical thermo-viscoplastic material.展开更多
A new meso-mechanical testing scheme based on SEM was developed to carry out the experiment of microfracturing process of rocks. The microfracturing process of the pre-crack marble sample on surrounding rock in the im...A new meso-mechanical testing scheme based on SEM was developed to carry out the experiment of microfracturing process of rocks. The microfracturing process of the pre-crack marble sample on surrounding rock in the immerged Long-big tunnel in Jinping Cascade II Hydropower Station under uniaxial compression was recorded by using the testing scheme. According to the stereology theory, the propagation and coalescent of cracks at meso-scale were quantitatively investigated with digital technology. Therefore, the basic geometric information of rock microcracks such as area, angle, length, width, perimeter, was obtained from binary images after segmentation. The failure mechanism of specimen under uniaxial compression with the quantitative information was studied from macro and microscopic point of view. The results show that the image of microfracturing process of the specimen can be observed and recorded digitally. During the damage of the specimen, the distribution of microcracks in the specimen is still subjected to exponential distribution with some microcracks concentrated in certain regions. Finally, the change law of the fractal dimension of the local element in marble sample under different external load conditions is obtained by means of the statistical calculation of the fractal dimension.展开更多
In the present work, the response of closed-cell aluminum foams under low-velocity impact has been studied numerically and experimentally. Computerized tomography is employed to access three-dimensional (3D) microstru...In the present work, the response of closed-cell aluminum foams under low-velocity impact has been studied numerically and experimentally. Computerized tomography is employed to access three-dimensional (3D) microstructure of the closed-cell aluminum foam. Effective parameters including foam density and the velocity of impactor on foam dynamic behavior are investigated. In order to show the validity and accuracy of results, some static experiments and low-velocity impact tests have been conducted. Results in dicate a remarkable agree me nt between the simulation and experimental data. Moreover, the results show that by increasing the density of foam samples, the highest difference between numerical and experimenidi results for peak stress and absorbed energy are 35.9% and 6.9%, respectively, which is related to the highest density. For impact velocities ranging from 3.1 to 4.2 m/s, the maximum discrepancy in peak stress and absorbed energy occur at an inipact velocity of 3.1 m/s in which corresponding errors are 33.3% and 6.6%, respectively. For the impact velocity of 40 m/s, the highest increase in peak stress and absorbed energy are 667.9% and 370.3% associated with the density of 0.5 and 0.3 g/cm^3, respectively.展开更多
The experimental modal analysis of the selected self-propelled gun was completed to obtain its modal frequency distribution and modes by using an operational modal analysis experimental technique.The result obtained b...The experimental modal analysis of the selected self-propelled gun was completed to obtain its modal frequency distribution and modes by using an operational modal analysis experimental technique.The result obtained by the method was compared with that obtained by the traditional method.It indicates that the two results are in good agreement.展开更多
In the recent past,the potential benefits of wraparound geosynthetic reinforcement technique for constructing the reinforced soil foundations have been reported.This paper presents the experimental study on the behavi...In the recent past,the potential benefits of wraparound geosynthetic reinforcement technique for constructing the reinforced soil foundations have been reported.This paper presents the experimental study on the behaviour of model strip footing resting on sandy soil bed reinforced with geosynthetic in wraparound and planar forms under monotonic and repeated loadings.The geosynthetic layers were laid according to the reinforcement ratio to minimise the scale effect.It is found that for the same amount of reinforcement material,the wraparound reinforced model resulted in less settlement in comparison to planar reinforced models.The efficiency of wraparound reinforced model increased with the increase in load amplitude and the rate of total cumulative settlement substantially decreased with the increase in number of load cycles.The wraparound reinforced model has shown about 45% lower average total settlement in comparison to unreinforced model,while the double-layer reinforced model has about 41% lower average total settlement at the cost of approximately twice the material and 1.5 times the occupied land width ratio.Moreover,wraparound models have shown much greater stability in comparison to their counterpart models when subjected to incremental repeated loading.展开更多
A large model of the screen was mounted in the laboratory for studying its modal performance. The model is suspended with steel ropes. Modal test was carried out with artificially exciting by 500 g impacting hammer an...A large model of the screen was mounted in the laboratory for studying its modal performance. The model is suspended with steel ropes. Modal test was carried out with artificially exciting by 500 g impacting hammer and 100 kg exciting force shaker respectively. Synthesis and correction of the modal parameters are obtained from both testing methods. Design faults of vibrating screen were determined based on the analy-sis and dynamic correction of structure approaches about the screen was put forward finally.展开更多
The phase referencing Very Long Baseline Interferometry(VLBI)technique is a newly developed tool to measure the angular position of a deep space exploration probe in the plane-of-the-sky.Through alternating observatio...The phase referencing Very Long Baseline Interferometry(VLBI)technique is a newly developed tool to measure the angular position of a deep space exploration probe in the plane-of-the-sky.Through alternating observations between the probe and a nearby reference radio source,their accurate relative angular separation can be obtained from the radio images generated by this technique.To meet the requirements of the current orbit determination software,differential delay should be firstly derived from those radio images.A method to resolve the differential phase delay from the phase referencing VLBI technique is proposed in this paper,and as well the mathematical model for differential phase ambiguity resolution is established.This method is verified with practical measurement data from the Chang’E-3 mission.The differential phase delay between the Chang’E-3 lander and rover was derived from the phase referencing VLBI measurements,and was then imported into the Shanghai astronomical observatory Orbit Determination Program(SODP)to calculate the position of the rover relative to the lander on the lunar surface.The results are consistent with those acquired directly from radio images,indicating that the differential phase ambiguity has been correctly resolved.The proposed method can be used to promote applications of the phase referencing VLBI technique in future lunar or deep space explorations,and more accurate orbit determination becomes promising.展开更多
Through a lot of experiments, a new kind of stove using horizontal combustion tech-nique for bituminous coal briquet has been developed. Making use of this stove, studies have been made on burning process of bituminou...Through a lot of experiments, a new kind of stove using horizontal combustion tech-nique for bituminous coal briquet has been developed. Making use of this stove, studies have been made on burning process of bituminous coal briquet, distribution of temperature field in the stove, the regularities of evolution and combustion of volatile matter, the burning rate and edi-ciency of bituminous coal briquet, characteristics of fire-sealing and sulfur-retention. The results show that, with the technique, some achievements can be obtained in combustion of bituminous coal briquet, such as lower pollution that the flue gas black degree is below 0. 5R and dust con-centration is below 90 mg/m3. The stove’s combustion efficiency reaches 90%, sulfur fixing effi-ciency is 60%, and oO concentration is decreased by 40% compared with other traditional stoves. With so many advantages, the stove can be used extensively in civil stoves and smaller industrial boilers.展开更多
BACKGROUND Gastric cancer(GC)has high morbidity and mortality.Moreover,because GC has no typical symptoms in the early stages,most cases are already in the advanced stages by the time the symptoms appear,thus resultin...BACKGROUND Gastric cancer(GC)has high morbidity and mortality.Moreover,because GC has no typical symptoms in the early stages,most cases are already in the advanced stages by the time the symptoms appear,thus resulting in poor prognosis and a low survival rate.Endoscopic submucosal dissection(ESD)can realize the early detection and diagnosis of GC and become the main surgical method for early GC.However,ESD has a steep learning curve and high technical skill requirements for endoscopists,which is not conducive to its widespread implementation and advancement.Therefore,a series of auxiliary techniques have been derived.AIM To evaluate the safety and efficacy of magnetic anchor technique(MAT)-assisted ESD in early GC.METHODS This was an ex vivo animal experiment.The experimental models were the isolated stomachs of pigs,which were divided into two groups,namely the study group(n=6)with MAT-assisted ESD and the control group(n=6)with traditional ESD.Comparing the total surgical time,incidence of surgical complications,complete mucosal resection rate,specimen size,and the scores of endoscopist’s satisfaction with the procedure reflected their feelings about convenience during the surgical procedure between the two groups.The magnetic anchor device for auxiliary ESD in the study group comprised three parts,an anchor magnet(AM),a target magnet(TM),and a soft tissue clip.Under gastroscopic guidance,the soft tissue clip and the TM were delivered to the pre-marked mucosal lesion through the gastroscopic operating hole.The soft tissue clip and the TM were connected by a thin wire through the TM tail structure.The soft tissue clip was released by manipulating the operating handle of the soft tissue clip in a way that the soft tissue clip and the TM were fixed to the lesion mucosa.In vitro,ESD is aided by maneuvering the AM such that the mucosal dissection surface is exposed.RESULTS The total surgical time was shorter in the study group than in the control group(26.57±0.19 vs 29.97±0.28,P<0.001),and the scores of endoscopist’s satisfaction with the procedure were higher in the study group than in the control group(9.53±0.10 vs 8.00±0.22,P<0.001).During the operation in the study group,there was no detachment of the soft tissue clip and TM and no mucosal tearing.The magnetic force between the AM and TM provided good mucosal exposure and sufficient tissue tension for ESD.The mucosal lesion was completely peeled off,and the operation was successful.There were no significant differences in the incidence of surgical complications(100%vs 83.3%),complete mucosal resection rate(100%vs 66.7%,P=0.439),and specimen size(2.44±0.04 cm vs 2.49±0.02,P=0.328)between the two groups.CONCLUSION MAT-ESD is safe and effective for early GC.It provides a preliminary basis for subsequent internal animal experiments and clinical research.展开更多
We study theoretically and experimentally the properties of numerical aperture(NA)of multimode graded-index plastic core silica(PCS)fibers by using an image technique.A He-Ne laser at wavelength 632.8 nm and output po...We study theoretically and experimentally the properties of numerical aperture(NA)of multimode graded-index plastic core silica(PCS)fibers by using an image technique.A He-Ne laser at wavelength 632.8 nm and output power 1 mW is used as the transmitter light source.The output beam images and intensity profiles of an optical fiber are investigated by using an imaging technique.The laser beam profiles captured by a sensitive digital Nikon camera are processed and analyzed by using a Gaussian intensity distribution in a 2D graph.A MathCAD 14 program is used for converting the image of the laser output beam into data.The theoretical and experimental values of the numerical aperture for the used optical fiber in this study are found to be 0.5 and 0.4924,respectively.The theoretical value of V-number is also calculated to be approximately 2482.展开更多
Vibration can be introduced in all mechanical fields in our life.Engineers try to avoid its negative effect leading in some cases to deformation in the machines.Many researches are dedicated to study the identificatio...Vibration can be introduced in all mechanical fields in our life.Engineers try to avoid its negative effect leading in some cases to deformation in the machines.Many researches are dedicated to study the identification of damping especially in multi degree of freedom systems with particular attention to the source of energy dissipation.They focus on developing new tools or methods which may be used in real problems to obtain accurate results about the amount(or value)and the location of energy dissipation in the structure.The aim of this paper is to present an original procedure aims to experimentally determine the modal damping ratio of a mechanical structure.The proposed procedure consists of extracting the Frequency Response Function of the vibrating system using the video magnification method and then calculate the modal damping ratio using the 3-dB method.These experimental measurements are carried out by giving an external force on a cantilever beam,then the modal damping ratios are extracted using motion magnification.The obtained results show a relative error less than 4.2% between the experimental measurements and the analytical calculation for the Frequency Response Function(FRF)curves.The novelty of the paper is to combine the video magnification technique and the 3dB method in a procedure that aims to experimentally measure the modal damping of a mechanical structure.The proposed procedure in this paper represents the damping identification as a simple and easy engineering application.展开更多
Lung cancer continues to be a leading cause of cancer-related deaths worldwide,emphasizing the critical need for improved diagnostic techniques.Early detection of lung tumors significantly increases the chances of suc...Lung cancer continues to be a leading cause of cancer-related deaths worldwide,emphasizing the critical need for improved diagnostic techniques.Early detection of lung tumors significantly increases the chances of successful treatment and survival.However,current diagnostic methods often fail to detect tumors at an early stage or to accurately pinpoint their location within the lung tissue.Single-model deep learning technologies for lung cancer detection,while beneficial,cannot capture the full range of features present in medical imaging data,leading to incomplete or inaccurate detection.Furthermore,it may not be robust enough to handle the wide variability in medical images due to different imaging conditions,patient anatomy,and tumor characteristics.To overcome these disadvantages,dual-model or multi-model approaches can be employed.This research focuses on enhancing the detection of lung cancer by utilizing a combination of two learning models:a Convolutional Neural Network(CNN)for categorization and the You Only Look Once(YOLOv8)architecture for real-time identification and pinpointing of tumors.CNNs automatically learn to extract hierarchical features from raw image data,capturing patterns such as edges,textures,and complex structures that are crucial for identifying lung cancer.YOLOv8 incorporates multiscale feature extraction,enabling the detection of tumors of varying sizes and scales within a single image.This is particularly beneficial for identifying small or irregularly shaped tumors that may be challenging to detect.Furthermore,through the utilization of cutting-edge data augmentation methods,such as Deep Convolutional Generative Adversarial Networks(DCGAN),the suggested approach can handle the issue of limited data and boost the models’ability to learn from diverse and comprehensive datasets.The combined method not only improved accuracy and localization but also ensured efficient real-time processing,which is crucial for practical clinical applications.The CNN achieved an accuracy of 97.67%in classifying lung tissues into healthy and cancerous categories.The YOLOv8 model achieved an Intersection over Union(IoU)score of 0.85 for tumor localization,reflecting high precision in detecting and marking tumor boundaries within the images.Finally,the incorporation of synthetic images generated by DCGAN led to a 10%improvement in both the CNN classification accuracy and YOLOv8 detection performance.展开更多
Plane charge explosion technique (PCET) is one of the major techniques frequently used in large-scale blast-resistant structure tests. An FEM model was established, which can simulate the process of air releasing from...Plane charge explosion technique (PCET) is one of the major techniques frequently used in large-scale blast-resistant structure tests. An FEM model was established, which can simulate the process of air releasing from the blast cavity. The effects of the charge density, the interval of the charge strip, the distance of the charges from the structure, and the mass of backfill soil on the overpressures applied on the tested structures were analyzed by the FEM model. The quantitative relationships between the peak value and the duration of the overpressure and the above-mentioned affecting parameters were established. Agreement between numerical results and the test data was obtained.展开更多
For strain measurement on offshore jacket platform in deep water, waterproof of strain foil is always an important issue, especially, due to the high pressure in deep water. The waterproof is difficult in two places, ...For strain measurement on offshore jacket platform in deep water, waterproof of strain foil is always an important issue, especially, due to the high pressure in deep water. The waterproof is difficult in two places, one is between the matrix structure and the protection structure, and another is between the lead wires and the protection structure. The surround protection technique discussed in this paper is conventional and ideal, and can be operative for a long time, up to five years. In this method, a metal case and tube is added on the local position, which increases the local rigidity, but the effect on the measurement of strain is not well studied. In this paper, the effect of the surround protection technique on the strain measurement is studied by using numerical and experimental methods, and the results show that the measurement error is well in the range permitted by engineering practice.展开更多
The article presents an experimental study on the flow of an eutectic gallium alloy in a cylindrical cell,which is placed in an alternating magnetic field.The magnetic field is generated by a coil connected to an alte...The article presents an experimental study on the flow of an eutectic gallium alloy in a cylindrical cell,which is placed in an alternating magnetic field.The magnetic field is generated by a coil connected to an alternating current source.The coil is located at a fixed height in such a way that its plane is perpendicular to the gravity vector,which in turn is parallel to the axis of the cylinder.The position of the cylinder can vary in height with respect to the coil.The forced flow of the considered electrically conductive liquid is generated due to the action of the localized electromagnetic force.It is assumed that under the action of the alternating magnetic field,the liquid is heated uniformly,and the resulting heat is quickly absorbed by the forced flow,so that liquid free convection can be neglected.The experiment is carried out using an ultrasonic Doppler anemometer.One transducer is installed in the axially located cylinder sluice and the other transducer is placed in the near-wall region.According to the results,a velocity profile,corresponding to a two-tori flow pattern can be hardly obtained in the low frequency range of the power supply.However,this is possible in the high frequency range.The average velocity profiles depend essentially on the location of the coil relative to the cell.The spectral analysis of velocity signals shows that the amplitude of the velocity pulsations is comparable to the average value of the flow velocity.Such experimental results and their verification through comparison with numerical calculations are intended to support the development of new methods for reducing the intensity of vortex flows during the electromagnetic separation of impurities through an electromagnetic induction mechanism(able to produce an electromotive force that displaces particles).展开更多
文摘Experimental therapies targeting immune and stromal cells,such as mast cells,cancer-associated fibroblasts,dendritic cells,and tumor endothelial cells,in the treatment of gastrointestinal solid tumors pose new and complex surgical and medico-legal challenges.These innovative treatments require that informed consent not be limited to simple acceptance of the medical procedure,but instead reflect a true relational and cognitive process grounded in understanding,free choice,and the ability to revoke consent at any time.In particular,it is essential that the patient understands the experimental nature of the therapy,its development stage,potential benefits and risks,as well as the implications for their health and personal dignity.In the case of stromal cell-based treatments,which may exert complex immunomodulatory effects or activate angiogenic pathways that are not yet fully understood,patients must be made fully aware that they are participating in a non-standardized therapy whose outcomes,whether beneficial or harmful,cannot yet be predicted with certainty.This requires particularly careful medical communication,using simple yet scientifically accurate explanations delivered in appropriate language,along with a final verification of the patient’s actual understanding.
基金supported by Healthy China initiative of Traditional Chinese Medicine(No.889042).
文摘Currently,the number of patients with myopia is increasing rapidly across the globe.Traditional Chinese medicine(TCM),with its long history and rich experience,has shown promise in effectively managing and treating this condition.Nevertheless,considering the vast amount of research that is currently being conducted,focusing on the utilization of TCM in the management of myopia,there is an urgent requirement for a thorough and comprehensive review.The review would serve to clarify the practical applications of TCM within this specific field,and it would also aim to elucidate the underlying mechanisms that are at play,providing a deeper understanding of how TCM principles can be effectively integrated into modern medical practices.Here,some modern medical pathogenesis of myopia and appropriate TCM techniques studies are summarized in the prevention and treatment of myopia.Further,we discussed the potential mechanisms and the future research directions of TCM against myopia.Identifying these mechanisms is crucial for understanding how TCM can be effectively utilized in this context.The combination of various TCM methods or the combination of traditional Chinese and Western medicine is of great significance for the prevention and control of myopia in the future.
基金supported by the Institute of Information&Communications Technology Planning&Evaluation(IITP)grant funded by the Korea government(MSIT)(No.RS-2023-00235509Development of security monitoring technology based network behavior against encrypted cyber threats in ICT convergence environment).
文摘With the increasing emphasis on personal information protection,encryption through security protocols has emerged as a critical requirement in data transmission and reception processes.Nevertheless,IoT ecosystems comprise heterogeneous networks where outdated systems coexist with the latest devices,spanning a range of devices from non-encrypted ones to fully encrypted ones.Given the limited visibility into payloads in this context,this study investigates AI-based attack detection methods that leverage encrypted traffic metadata,eliminating the need for decryption and minimizing system performance degradation—especially in light of these heterogeneous devices.Using the UNSW-NB15 and CICIoT-2023 dataset,encrypted and unencrypted traffic were categorized according to security protocol,and AI-based intrusion detection experiments were conducted for each traffic type based on metadata.To mitigate the problem of class imbalance,eight different data sampling techniques were applied.The effectiveness of these sampling techniques was then comparatively analyzed using two ensemble models and three Deep Learning(DL)models from various perspectives.The experimental results confirmed that metadata-based attack detection is feasible using only encrypted traffic.In the UNSW-NB15 dataset,the f1-score of encrypted traffic was approximately 0.98,which is 4.3%higher than that of unencrypted traffic(approximately 0.94).In addition,analysis of the encrypted traffic in the CICIoT-2023 dataset using the same method showed a significantly lower f1-score of roughly 0.43,indicating that the quality of the dataset and the preprocessing approach have a substantial impact on detection performance.Furthermore,when data sampling techniques were applied to encrypted traffic,the recall in the UNSWNB15(Encrypted)dataset improved by up to 23.0%,and in the CICIoT-2023(Encrypted)dataset by 20.26%,showing a similar level of improvement.Notably,in CICIoT-2023,f1-score and Receiver Operation Characteristic-Area Under the Curve(ROC-AUC)increased by 59.0%and 55.94%,respectively.These results suggest that data sampling can have a positive effect even in encrypted environments.However,the extent of the improvement may vary depending on data quality,model architecture,and sampling strategy.
基金supported by the National Natural Science Foundation of China,No.31760290,82160688the Key Development Areas Project of Ganzhou Science and Technology,No.2022B-SF9554(all to XL)。
文摘Synaptic pruning is a crucial process in synaptic refinement,eliminating unstable synaptic connections in neural circuits.This process is triggered and regulated primarily by spontaneous neural activity and experience-dependent mechanisms.The pruning process involves multiple molecular signals and a series of regulatory activities governing the“eat me”and“don't eat me”states.Under physiological conditions,the interaction between glial cells and neurons results in the clearance of unnecessary synapses,maintaining normal neural circuit functionality via synaptic pruning.Alterations in genetic and environmental factors can lead to imbalanced synaptic pruning,thus promoting the occurrence and development of autism spectrum disorder,schizophrenia,Alzheimer's disease,and other neurological disorders.In this review,we investigated the molecular mechanisms responsible for synaptic pruning during neural development.We focus on how synaptic pruning can regulate neural circuits and its association with neurological disorders.Furthermore,we discuss the application of emerging optical and imaging technologies to observe synaptic structure and function,as well as their potential for clinical translation.Our aim was to enhance our understanding of synaptic pruning during neural development,including the molecular basis underlying the regulation of synaptic function and the dynamic changes in synaptic density,and to investigate the potential role of these mechanisms in the pathophysiology of neurological diseases,thus providing a theoretical foundation for the treatment of neurological disorders.
文摘THE Nanjing Yunjin brocade,known for its stunning luster,exquisite patterns,and a wealth of shades,represents the highest level of Chinese brocade craftsmanship.It was the designated textile for the imperial courts of the Yuan(1206-1368),Ming(1368-1644),and Qing(1616-1911)dynasties,and is still highly regarded to this day.
文摘Based on loading-unloading test, tensile impact recovery experimental techniques have been developed to obtain the isothermal stress-strain curves of materials under high strain rates. The thermal softening effect can be decoupled by comparing the isothermal stress-strain curves with the adiabatic stress-strain curves at the same strain rate. In the present paper, recovery experiments of brass have been carried out on a self-designed rotating disk tensile impact apparatus. According to the parabolic strain hardening power-law thermo-viscoplastic constitutive model, strain hardening parameter, strain rates strengthening parameter and thermal softening synthetical parameter have been decoupled from experimental results. Furthermore, from these parameters, one can determine the theoretical isothermal curves and adiabatic curves at high strain rates well-coinciding the experimental results respectively. It indicates that the recovery experimental techniques of tensile impact are effective and reliable and are important means for the study of thermo-mechanical coupling. The experimental results also reveals that brass is a typical thermo-viscoplastic material.
基金Projects(50674040, 50539090) supported by the National Natural Science Foundation of ChinaProject(CX07B_128z) supported by the Cultivate Creative Postgraduate Foundation of Jiangsu Province, China
文摘A new meso-mechanical testing scheme based on SEM was developed to carry out the experiment of microfracturing process of rocks. The microfracturing process of the pre-crack marble sample on surrounding rock in the immerged Long-big tunnel in Jinping Cascade II Hydropower Station under uniaxial compression was recorded by using the testing scheme. According to the stereology theory, the propagation and coalescent of cracks at meso-scale were quantitatively investigated with digital technology. Therefore, the basic geometric information of rock microcracks such as area, angle, length, width, perimeter, was obtained from binary images after segmentation. The failure mechanism of specimen under uniaxial compression with the quantitative information was studied from macro and microscopic point of view. The results show that the image of microfracturing process of the specimen can be observed and recorded digitally. During the damage of the specimen, the distribution of microcracks in the specimen is still subjected to exponential distribution with some microcracks concentrated in certain regions. Finally, the change law of the fractal dimension of the local element in marble sample under different external load conditions is obtained by means of the statistical calculation of the fractal dimension.
文摘In the present work, the response of closed-cell aluminum foams under low-velocity impact has been studied numerically and experimentally. Computerized tomography is employed to access three-dimensional (3D) microstructure of the closed-cell aluminum foam. Effective parameters including foam density and the velocity of impactor on foam dynamic behavior are investigated. In order to show the validity and accuracy of results, some static experiments and low-velocity impact tests have been conducted. Results in dicate a remarkable agree me nt between the simulation and experimental data. Moreover, the results show that by increasing the density of foam samples, the highest difference between numerical and experimenidi results for peak stress and absorbed energy are 35.9% and 6.9%, respectively, which is related to the highest density. For impact velocities ranging from 3.1 to 4.2 m/s, the maximum discrepancy in peak stress and absorbed energy occur at an inipact velocity of 3.1 m/s in which corresponding errors are 33.3% and 6.6%, respectively. For the impact velocity of 40 m/s, the highest increase in peak stress and absorbed energy are 667.9% and 370.3% associated with the density of 0.5 and 0.3 g/cm^3, respectively.
文摘The experimental modal analysis of the selected self-propelled gun was completed to obtain its modal frequency distribution and modes by using an operational modal analysis experimental technique.The result obtained by the method was compared with that obtained by the traditional method.It indicates that the two results are in good agreement.
基金funded by the Higher Education Commission(HEC),Government of the Islamic Republic of Pakistan and Edith Cowan University,Perth,Australia。
文摘In the recent past,the potential benefits of wraparound geosynthetic reinforcement technique for constructing the reinforced soil foundations have been reported.This paper presents the experimental study on the behaviour of model strip footing resting on sandy soil bed reinforced with geosynthetic in wraparound and planar forms under monotonic and repeated loadings.The geosynthetic layers were laid according to the reinforcement ratio to minimise the scale effect.It is found that for the same amount of reinforcement material,the wraparound reinforced model resulted in less settlement in comparison to planar reinforced models.The efficiency of wraparound reinforced model increased with the increase in load amplitude and the rate of total cumulative settlement substantially decreased with the increase in number of load cycles.The wraparound reinforced model has shown about 45% lower average total settlement in comparison to unreinforced model,while the double-layer reinforced model has about 41% lower average total settlement at the cost of approximately twice the material and 1.5 times the occupied land width ratio.Moreover,wraparound models have shown much greater stability in comparison to their counterpart models when subjected to incremental repeated loading.
基金Supported by Provincial Natural Science Foundation of Shanxi(20031046)
文摘A large model of the screen was mounted in the laboratory for studying its modal performance. The model is suspended with steel ropes. Modal test was carried out with artificially exciting by 500 g impacting hammer and 100 kg exciting force shaker respectively. Synthesis and correction of the modal parameters are obtained from both testing methods. Design faults of vibrating screen were determined based on the analy-sis and dynamic correction of structure approaches about the screen was put forward finally.
基金the National Natural Science Foundation of China(Grant Nos.42030110,61603008 and U1831132)the Innovation Group of Natural Fund of Hubei Province(2018CFA087)。
文摘The phase referencing Very Long Baseline Interferometry(VLBI)technique is a newly developed tool to measure the angular position of a deep space exploration probe in the plane-of-the-sky.Through alternating observations between the probe and a nearby reference radio source,their accurate relative angular separation can be obtained from the radio images generated by this technique.To meet the requirements of the current orbit determination software,differential delay should be firstly derived from those radio images.A method to resolve the differential phase delay from the phase referencing VLBI technique is proposed in this paper,and as well the mathematical model for differential phase ambiguity resolution is established.This method is verified with practical measurement data from the Chang’E-3 mission.The differential phase delay between the Chang’E-3 lander and rover was derived from the phase referencing VLBI measurements,and was then imported into the Shanghai astronomical observatory Orbit Determination Program(SODP)to calculate the position of the rover relative to the lander on the lunar surface.The results are consistent with those acquired directly from radio images,indicating that the differential phase ambiguity has been correctly resolved.The proposed method can be used to promote applications of the phase referencing VLBI technique in future lunar or deep space explorations,and more accurate orbit determination becomes promising.
文摘Through a lot of experiments, a new kind of stove using horizontal combustion tech-nique for bituminous coal briquet has been developed. Making use of this stove, studies have been made on burning process of bituminous coal briquet, distribution of temperature field in the stove, the regularities of evolution and combustion of volatile matter, the burning rate and edi-ciency of bituminous coal briquet, characteristics of fire-sealing and sulfur-retention. The results show that, with the technique, some achievements can be obtained in combustion of bituminous coal briquet, such as lower pollution that the flue gas black degree is below 0. 5R and dust con-centration is below 90 mg/m3. The stove’s combustion efficiency reaches 90%, sulfur fixing effi-ciency is 60%, and oO concentration is decreased by 40% compared with other traditional stoves. With so many advantages, the stove can be used extensively in civil stoves and smaller industrial boilers.
基金Supported by the Key Research&Development Program-Social Development of Shaanxi Province of China,No.2021SF-163the Innovation Capability Support Plan of Shaanxi Province of China,No.2020KJXX-022.
文摘BACKGROUND Gastric cancer(GC)has high morbidity and mortality.Moreover,because GC has no typical symptoms in the early stages,most cases are already in the advanced stages by the time the symptoms appear,thus resulting in poor prognosis and a low survival rate.Endoscopic submucosal dissection(ESD)can realize the early detection and diagnosis of GC and become the main surgical method for early GC.However,ESD has a steep learning curve and high technical skill requirements for endoscopists,which is not conducive to its widespread implementation and advancement.Therefore,a series of auxiliary techniques have been derived.AIM To evaluate the safety and efficacy of magnetic anchor technique(MAT)-assisted ESD in early GC.METHODS This was an ex vivo animal experiment.The experimental models were the isolated stomachs of pigs,which were divided into two groups,namely the study group(n=6)with MAT-assisted ESD and the control group(n=6)with traditional ESD.Comparing the total surgical time,incidence of surgical complications,complete mucosal resection rate,specimen size,and the scores of endoscopist’s satisfaction with the procedure reflected their feelings about convenience during the surgical procedure between the two groups.The magnetic anchor device for auxiliary ESD in the study group comprised three parts,an anchor magnet(AM),a target magnet(TM),and a soft tissue clip.Under gastroscopic guidance,the soft tissue clip and the TM were delivered to the pre-marked mucosal lesion through the gastroscopic operating hole.The soft tissue clip and the TM were connected by a thin wire through the TM tail structure.The soft tissue clip was released by manipulating the operating handle of the soft tissue clip in a way that the soft tissue clip and the TM were fixed to the lesion mucosa.In vitro,ESD is aided by maneuvering the AM such that the mucosal dissection surface is exposed.RESULTS The total surgical time was shorter in the study group than in the control group(26.57±0.19 vs 29.97±0.28,P<0.001),and the scores of endoscopist’s satisfaction with the procedure were higher in the study group than in the control group(9.53±0.10 vs 8.00±0.22,P<0.001).During the operation in the study group,there was no detachment of the soft tissue clip and TM and no mucosal tearing.The magnetic force between the AM and TM provided good mucosal exposure and sufficient tissue tension for ESD.The mucosal lesion was completely peeled off,and the operation was successful.There were no significant differences in the incidence of surgical complications(100%vs 83.3%),complete mucosal resection rate(100%vs 66.7%,P=0.439),and specimen size(2.44±0.04 cm vs 2.49±0.02,P=0.328)between the two groups.CONCLUSION MAT-ESD is safe and effective for early GC.It provides a preliminary basis for subsequent internal animal experiments and clinical research.
文摘We study theoretically and experimentally the properties of numerical aperture(NA)of multimode graded-index plastic core silica(PCS)fibers by using an image technique.A He-Ne laser at wavelength 632.8 nm and output power 1 mW is used as the transmitter light source.The output beam images and intensity profiles of an optical fiber are investigated by using an imaging technique.The laser beam profiles captured by a sensitive digital Nikon camera are processed and analyzed by using a Gaussian intensity distribution in a 2D graph.A MathCAD 14 program is used for converting the image of the laser output beam into data.The theoretical and experimental values of the numerical aperture for the used optical fiber in this study are found to be 0.5 and 0.4924,respectively.The theoretical value of V-number is also calculated to be approximately 2482.
文摘Vibration can be introduced in all mechanical fields in our life.Engineers try to avoid its negative effect leading in some cases to deformation in the machines.Many researches are dedicated to study the identification of damping especially in multi degree of freedom systems with particular attention to the source of energy dissipation.They focus on developing new tools or methods which may be used in real problems to obtain accurate results about the amount(or value)and the location of energy dissipation in the structure.The aim of this paper is to present an original procedure aims to experimentally determine the modal damping ratio of a mechanical structure.The proposed procedure consists of extracting the Frequency Response Function of the vibrating system using the video magnification method and then calculate the modal damping ratio using the 3-dB method.These experimental measurements are carried out by giving an external force on a cantilever beam,then the modal damping ratios are extracted using motion magnification.The obtained results show a relative error less than 4.2% between the experimental measurements and the analytical calculation for the Frequency Response Function(FRF)curves.The novelty of the paper is to combine the video magnification technique and the 3dB method in a procedure that aims to experimentally measure the modal damping of a mechanical structure.The proposed procedure in this paper represents the damping identification as a simple and easy engineering application.
文摘Lung cancer continues to be a leading cause of cancer-related deaths worldwide,emphasizing the critical need for improved diagnostic techniques.Early detection of lung tumors significantly increases the chances of successful treatment and survival.However,current diagnostic methods often fail to detect tumors at an early stage or to accurately pinpoint their location within the lung tissue.Single-model deep learning technologies for lung cancer detection,while beneficial,cannot capture the full range of features present in medical imaging data,leading to incomplete or inaccurate detection.Furthermore,it may not be robust enough to handle the wide variability in medical images due to different imaging conditions,patient anatomy,and tumor characteristics.To overcome these disadvantages,dual-model or multi-model approaches can be employed.This research focuses on enhancing the detection of lung cancer by utilizing a combination of two learning models:a Convolutional Neural Network(CNN)for categorization and the You Only Look Once(YOLOv8)architecture for real-time identification and pinpointing of tumors.CNNs automatically learn to extract hierarchical features from raw image data,capturing patterns such as edges,textures,and complex structures that are crucial for identifying lung cancer.YOLOv8 incorporates multiscale feature extraction,enabling the detection of tumors of varying sizes and scales within a single image.This is particularly beneficial for identifying small or irregularly shaped tumors that may be challenging to detect.Furthermore,through the utilization of cutting-edge data augmentation methods,such as Deep Convolutional Generative Adversarial Networks(DCGAN),the suggested approach can handle the issue of limited data and boost the models’ability to learn from diverse and comprehensive datasets.The combined method not only improved accuracy and localization but also ensured efficient real-time processing,which is crucial for practical clinical applications.The CNN achieved an accuracy of 97.67%in classifying lung tissues into healthy and cancerous categories.The YOLOv8 model achieved an Intersection over Union(IoU)score of 0.85 for tumor localization,reflecting high precision in detecting and marking tumor boundaries within the images.Finally,the incorporation of synthetic images generated by DCGAN led to a 10%improvement in both the CNN classification accuracy and YOLOv8 detection performance.
文摘Plane charge explosion technique (PCET) is one of the major techniques frequently used in large-scale blast-resistant structure tests. An FEM model was established, which can simulate the process of air releasing from the blast cavity. The effects of the charge density, the interval of the charge strip, the distance of the charges from the structure, and the mass of backfill soil on the overpressures applied on the tested structures were analyzed by the FEM model. The quantitative relationships between the peak value and the duration of the overpressure and the above-mentioned affecting parameters were established. Agreement between numerical results and the test data was obtained.
文摘For strain measurement on offshore jacket platform in deep water, waterproof of strain foil is always an important issue, especially, due to the high pressure in deep water. The waterproof is difficult in two places, one is between the matrix structure and the protection structure, and another is between the lead wires and the protection structure. The surround protection technique discussed in this paper is conventional and ideal, and can be operative for a long time, up to five years. In this method, a metal case and tube is added on the local position, which increases the local rigidity, but the effect on the measurement of strain is not well studied. In this paper, the effect of the surround protection technique on the strain measurement is studied by using numerical and experimental methods, and the results show that the measurement error is well in the range permitted by engineering practice.
基金supported by Russian Science Foundation Grant RSF-22-19-20106。
文摘The article presents an experimental study on the flow of an eutectic gallium alloy in a cylindrical cell,which is placed in an alternating magnetic field.The magnetic field is generated by a coil connected to an alternating current source.The coil is located at a fixed height in such a way that its plane is perpendicular to the gravity vector,which in turn is parallel to the axis of the cylinder.The position of the cylinder can vary in height with respect to the coil.The forced flow of the considered electrically conductive liquid is generated due to the action of the localized electromagnetic force.It is assumed that under the action of the alternating magnetic field,the liquid is heated uniformly,and the resulting heat is quickly absorbed by the forced flow,so that liquid free convection can be neglected.The experiment is carried out using an ultrasonic Doppler anemometer.One transducer is installed in the axially located cylinder sluice and the other transducer is placed in the near-wall region.According to the results,a velocity profile,corresponding to a two-tori flow pattern can be hardly obtained in the low frequency range of the power supply.However,this is possible in the high frequency range.The average velocity profiles depend essentially on the location of the coil relative to the cell.The spectral analysis of velocity signals shows that the amplitude of the velocity pulsations is comparable to the average value of the flow velocity.Such experimental results and their verification through comparison with numerical calculations are intended to support the development of new methods for reducing the intensity of vortex flows during the electromagnetic separation of impurities through an electromagnetic induction mechanism(able to produce an electromotive force that displaces particles).
