1 Introduction In contrast,1experimental geochemistry is a young subject,but in recent years,the research on experiment of high temperature and high pressure has become an important branch in the parallel subjects of ...1 Introduction In contrast,1experimental geochemistry is a young subject,but in recent years,the research on experiment of high temperature and high pressure has become an important branch in the parallel subjects of traditional mineralogy,petrology,geochemistry and geophysics.It is not only an important and essential way and window to understand geological processes in depth and geological展开更多
Circular double stranded DNA has different topological states which are defined by their linking numbers.Equilibrium distribution of linking numbers can be obtained by closing a linear DNA into a circle by ligase.Usin...Circular double stranded DNA has different topological states which are defined by their linking numbers.Equilibrium distribution of linking numbers can be obtained by closing a linear DNA into a circle by ligase.Using Monte Carlo simulation,we predict the temperature dependence of the linking number distribution of small circular DNAs.Our predictions are based on flexible defect excitations resulted from local melting or unstacking of DNA base pairs.We found that the reduced bending rigidity alone can lead to measurable changes of the variance of linking number distribution of short circular DNAs.展开更多
基金project was jointly funded by the Funds for the program of the National Natural Science Foundation (Noes. 41572060, U1133602)Projects of YM Lab (2011)Innovation Team of Yunnan province and KMUST (2008,2012)
文摘1 Introduction In contrast,1experimental geochemistry is a young subject,but in recent years,the research on experiment of high temperature and high pressure has become an important branch in the parallel subjects of traditional mineralogy,petrology,geochemistry and geophysics.It is not only an important and essential way and window to understand geological processes in depth and geological
基金supported by the Young Investigator Award received by Yan in 2006the Foundation for the Visiting PhD Candidate of the Chinese Academy of Science received by Liu in 2006
文摘Circular double stranded DNA has different topological states which are defined by their linking numbers.Equilibrium distribution of linking numbers can be obtained by closing a linear DNA into a circle by ligase.Using Monte Carlo simulation,we predict the temperature dependence of the linking number distribution of small circular DNAs.Our predictions are based on flexible defect excitations resulted from local melting or unstacking of DNA base pairs.We found that the reduced bending rigidity alone can lead to measurable changes of the variance of linking number distribution of short circular DNAs.
