期刊文献+
共找到1,164篇文章
< 1 2 59 >
每页显示 20 50 100
基于UHPLC-Q-Exactive-MS与网络药理学探讨芩柏软膏外用治疗银屑病的作用机制
1
作者 张林华 贾利影 +5 位作者 关佳莉 徐媛媛 拱健婷 丛悦 李萍 韩旭阳 《中国现代中药》 2026年第2期283-292,共10页
目的:采用超高效液相色谱-四极杆-轨道离子阱高分辨质谱法(UHPLC-Q-Exactive-MS)鉴定芩柏软膏的主要化学成分,结合网络药理学和分子对接技术,探讨其治疗银屑病的作用机制。方法:通过质谱数据采集,结合对照品比对、相关文献查阅及数据库... 目的:采用超高效液相色谱-四极杆-轨道离子阱高分辨质谱法(UHPLC-Q-Exactive-MS)鉴定芩柏软膏的主要化学成分,结合网络药理学和分子对接技术,探讨其治疗银屑病的作用机制。方法:通过质谱数据采集,结合对照品比对、相关文献查阅及数据库检索,鉴定并表征芩柏软膏的化学成分;从SwissTargetPrediction数据库获取药物潜在靶点,利用GeneCards、OMIM、TTD、DrugBank数据库筛选银屑病的相关疾病靶点,取两者交集得到共同靶点;借助String数据库和Cytoscape 3.9.1软件构建蛋白质-蛋白质相互作用网络并筛选核心靶点;利用Metascape平台对交集靶点进行基因本体(GO)功能和京都基因与基因组百科全书(KEGG)通路分析,最后通过AutoDock与Pymol软件对预测的靶点及其对应的成分进行分子对接验证。结果:从芩柏软膏中鉴定出50个化合物。筛选得到治疗银屑病的共同靶点180个,其作用机制可能涉及磷脂酰肌醇3-激酶-蛋白激酶B(PI3K-Akt)、丝裂原活化蛋白激酶(MAPK)、缺氧诱导因子-1(HIF-1)信号通路等,肿瘤蛋白p53(TP53)、缺氧诱导因子-1α(HIF1A)、Jun原癌基因(JUN)、信号转导和转录激活因子(STAT3)、B淋巴细胞瘤-2(BCL2)、MAPK1等关键靶点。结论:本研究较全面地分析了芩柏软膏的化学成分,初步推测其可能通过多组分、多靶点、多通路发挥治疗银屑病的作用,为其临床应用及后续实验提供参考。 展开更多
关键词 超高效液相色谱-四极杆-轨道离子阱高分辨质谱法 网络药理学 分子对接 芩柏软膏 银屑病 分子机制 信号通路
暂未订购
An Exact Analytical Method for Magnetic Field Computation and Electromagnetic Torque in a Concentric Magnetic Gear 被引量:11
2
作者 JING Libing ZHANG Yuejin 《中国电机工程学报》 EI CSCD 北大核心 2012年第30期I0020-I0020,22,共1页
准确计算磁力齿轮电磁转矩是设计、分析磁力齿轮的关键,采用二维全局解析法计算同心式磁力齿轮气隙磁场。求解场域划分为内外转子永磁体、内外两层气隙和调磁定子的槽形区域,3类子区域的拉普拉斯方程和泊松方程通过边界连续条件建立联... 准确计算磁力齿轮电磁转矩是设计、分析磁力齿轮的关键,采用二维全局解析法计算同心式磁力齿轮气隙磁场。求解场域划分为内外转子永磁体、内外两层气隙和调磁定子的槽形区域,3类子区域的拉普拉斯方程和泊松方程通过边界连续条件建立联系。得到内外两层气隙区域的矢量磁位磁通密度解析表达式,有利于方便、快速、精确地计算任意转子位置的电磁转矩。计算了内外两层气隙磁场和内外转子电磁转矩,将气隙磁场波形和内外转子电磁转矩波形分别与二维有限元法计算波形作比较,结果吻合,证明了方法的正确性和有效性。 展开更多
关键词 磁场计算 精确分析 电磁转矩 齿轮 磁力 磁场分布 泊松方程 拉普拉斯
原文传递
Exactness of penalization for exact minimax penalty function method in nonconvex programming 被引量:3
3
作者 T.ANTCZAK 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2015年第4期541-556,共16页
The exact minimax penalty function method is used to solve a noncon- vex differentiable optimization problem with both inequality and equality constraints. The conditions for exactness of the penalization for the exac... The exact minimax penalty function method is used to solve a noncon- vex differentiable optimization problem with both inequality and equality constraints. The conditions for exactness of the penalization for the exact minimax penalty function method are established by assuming that the functions constituting the considered con- strained optimization problem are invex with respect to the same function η (with the exception of those equality constraints for which the associated Lagrange multipliers are negative these functions should be assumed to be incave with respect to η). Thus, a threshold of the penalty parameter is given such that, for all penalty parameters exceeding this threshold, equivalence holds between the set of optimal solutions in the considered constrained optimization problem and the set of minimizer in its associated penalized problem with an exact minimax penalty function. It is shown that coercivity is not suf- ficient to prove the results. 展开更多
关键词 exact minimax penalty function method minimax penalized optimizationproblem exactness of penalization of exact minimax penalty function invex function incave function
在线阅读 下载PDF
Trial function method and exact solutions to the generalized nonlinear Schrdinger equation with time-dependent coefficient 被引量:2
4
作者 曹瑞 张健 《Chinese Physics B》 SCIE EI CAS CSCD 2013年第10期182-185,共4页
In this paper, the trial function method is extended to study the generalized nonlinear Schrodinger equation with time- dependent coefficients. On the basis of a generalized traveling wave transformation and a trial f... In this paper, the trial function method is extended to study the generalized nonlinear Schrodinger equation with time- dependent coefficients. On the basis of a generalized traveling wave transformation and a trial function, we investigate the exact envelope traveling wave solutions of the generalized nonlinear Schrodinger equation with time-dependent coefficients. Taking advantage of solutions to trial function, we successfully obtain exact solutions for the generalized nonlinear Schrodinger equation with time-dependent coefficients under constraint conditions. 展开更多
关键词 generalized nonlinear SchriSdinger equation exact solution trial function method
原文传递
NEW TIME-EXPLICIT ASYMPTOTIC METHOD FOR THESOLUTION OF AN EXACT CONTROLLABILITYPROBLEM OF SCATTERING WAVES 被引量:1
5
作者 陈红全 隋洪涛 《Chinese Journal of Aeronautics》 SCIE EI CSCD 2000年第2期80-85,共6页
In this paper a new time explicit asymptotic method is presented through introducing an auxiliary parameter for the solution of an exact controllability problem of scattering waves. Based on an exact control function... In this paper a new time explicit asymptotic method is presented through introducing an auxiliary parameter for the solution of an exact controllability problem of scattering waves. Based on an exact control function, the asymptotic iteration is controlled by the auxiliary parameter and the optimal auxiliary parameter is updated during the iteration based on the existing or current iterated solutions of the wave equation. The numerical results show that the new method presented has a significant advantage over the purely asymptotic method in the history of convergence and has the ability to solve the scattering by the multi bodies. 展开更多
关键词 exact controllability Maxwell equation asymptotic method
在线阅读 下载PDF
Exact solutions for the coupled Klein-Gordon-Schrǒdinger equations using the extended F-expansion method 被引量:1
6
作者 何红生 陈江 杨孔庆 《Chinese Physics B》 SCIE EI CAS CSCD 2005年第10期1926-1931,共6页
The extended F-expansion method or mapping method is used to construct exact solutions for the coupled KleinGordon Schr/Sdinger equations (K-G-S equations) by the aid of the symbolic computation system Mathematica. ... The extended F-expansion method or mapping method is used to construct exact solutions for the coupled KleinGordon Schr/Sdinger equations (K-G-S equations) by the aid of the symbolic computation system Mathematica. More solutions in the Jacobi elliptic function form are obtained, including the single Jacobi elliptic function solutions, combined Jacobi elliptic function solutions, rational solutions, triangular solutions, soliton solutions and combined soliton solutions. 展开更多
关键词 extended F-expansion method exact solutions coupled K-G-S equations Jacobi elliptic function
原文传递
AN EXACT ELEMENT METHOD FOR BENDING OF NONHOMOGENEOUS THIN PLATES
7
作者 纪振义 叶开沅 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 1992年第8期683-690,共8页
In this paper, based on the step reduction method, a new method, the exact element method for constructing finite element, is presented. Since the new method doesn 't need the variational principle, it can be appl... In this paper, based on the step reduction method, a new method, the exact element method for constructing finite element, is presented. Since the new method doesn 't need the variational principle, it can be applied to solve non-positive and positive definite partial differential equations with arbitrary variable coefficient. By this method, a triangle noncompatible element with 6 degrees of freedom is derived to solve the bending of nonhomogeneous plate. The convergence of displacements and stress resultants which have satisfactory numerical precision is proved. Numerical examples are given at the end of this paper, which indicate satisfactory results of stress resultants and displacements can be obtained by the present method. 展开更多
关键词 ALGORITHM nonhomogeneous thin plate BENDING exact element method
在线阅读 下载PDF
A New Method for the Exact Solution of Duffing Equation 被引量:1
8
作者 Ossou Nazila Fred Nelson Zheng Yu +1 位作者 Bambi Prince Dorian Yuya Wang 《Journal of Applied Mathematics and Physics》 2018年第12期2718-2726,共9页
A lot of methods, such as Jacobian elliptic function analysis, are used to look for the explicit exact solution of Duffing differential equation. The key of the analysis is to construct quotient trigonometric function... A lot of methods, such as Jacobian elliptic function analysis, are used to look for the explicit exact solution of Duffing differential equation. The key of the analysis is to construct quotient trigonometric function, and then nonlinear algebraic equation set theory and method are used for the solution of some kinds of nonlinear Duffing differential equation. In this paper, the exact solution of Duffing equation is obtained by using constant variation method, making use of the formula to solve cubic equations and general solution of the homogeneous equation of Duffing equation with appropriate Constant m and function f(t) . 展开更多
关键词 DUFFING Equation exact Solution CONSTANT Variation method
在线阅读 下载PDF
A HIGH CONVERGENT PRECISION EXACT ANALYTIC METHOD FOR DIFFERENTIAL EQUATION WITH VARIABLE COEFFICIENTS
9
作者 纪振义 叶开沅 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 1993年第3期201-207,共7页
The exact analytic method was given by [1] . It can be used for arbitrary variable coefficient differential equations and the solution obtained can have the second order convergent precision. In this paper, a new high... The exact analytic method was given by [1] . It can be used for arbitrary variable coefficient differential equations and the solution obtained can have the second order convergent precision. In this paper, a new high precision algorithm is given based on [1], through a bending problem of variable cross-section beams. It can have the fourth convergent precision without increasing computation work. The present computation method is not only simple but also fast. The numerical examples are given at the end of this paper which indicate that the high convergent precision can be obtained using only a few elements. The correctness of the theory in this paper is confirmed. 展开更多
关键词 exact analytic method bending of beam high convergent precision
在线阅读 下载PDF
SUBSTRUCTURE COMPUTATIONAL ALGORITHM FOR EXACT ANALYTIC METHOD
10
作者 纪振义 叶开沅 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 1990年第10期913-919,共7页
In[1], the exact analytic method for the solution of differential equation with variable coefficients was suggested and an analytic expression of solution was given by initial parameter algorithm. But to some problems... In[1], the exact analytic method for the solution of differential equation with variable coefficients was suggested and an analytic expression of solution was given by initial parameter algorithm. But to some problems such as the bending, free vibration and buckling of nonhomogeneous long cylinders, it is difficult to obtain their solutions by the initial parameter algorithm on computer. In this paper, the substructure computational algorithm for the exact analytic method is presented through the bending of non-homogeneous long cylindrical shell. This substructure algorithm can he applied to solve the problems which can not he calculated by the initial parameter algorithm on computer. Finally, the problems can he reduced to solving a low order system of algehraic equations like the initial parameter algorithm Numerical examples are given and compared with the initial para-algorithm at the end of the paper, which confirms the correctness of the substructure computational algorithm. 展开更多
关键词 substructure computational algorithm exact analytic method long cylindrical shell
在线阅读 下载PDF
New Exact Explicit Solutions of the Generalized Zakharov Equation via the First Integral Method 被引量:1
11
作者 Yuhuai Sun Hanlei Hu Jian Zhang 《Open Journal of Applied Sciences》 2014年第5期249-257,共9页
The generalized Zakharov equation is a coupled equation which is a classic nonlinear mathematic model in plasma. A series of new exact explicit solutions of the system are obtained, by means of the first integral meth... The generalized Zakharov equation is a coupled equation which is a classic nonlinear mathematic model in plasma. A series of new exact explicit solutions of the system are obtained, by means of the first integral method, in the form of trigonometric and exponential functions. The results show the first integral method is an efficient way to solve the coupled nonlinear equations and get rich explicit analytical solutions. 展开更多
关键词 GENERALIZED ZAKHAROV EQUATION First INTEGRAL method exact EXPLICIT Solutions
在线阅读 下载PDF
AN EXACT ELEMENT METHOD FOR THE BENDING OF NONHOMOGENEOUS REISSNER’S PLATE
12
作者 纪振义 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 1991年第11期1065-1074,共10页
In this paper, based on the step reduction method and exaet analytic method, a new method, theexacl element method for constructing finite element, is presented. Since the near method doesn't need varialional prin... In this paper, based on the step reduction method and exaet analytic method, a new method, theexacl element method for constructing finite element, is presented. Since the near method doesn't need varialional principle, it can he applied to solve nun-positive and positive definite partial differcntial equations with arbitral varutble coefficients. By this method, a triangle noncompatible element with 15 degrees of freedom is derived to solve the bending of nonhomogenous Reissner's plate. Because the displacement parameters at the nodal point only contain deflection and rotation angle, it is convenient to deal with arbitrary boundary conditions. In this paper, the convergcnceof displacement and stress resultants is proved. The element obtained by the present method can be used for thin and thick plates as well, hour numerical examples are given at the end of this paper, which indicates that we can obtain satisfactory results and have higher numerical precision. 展开更多
关键词 thick plate exact finite element method incompatible element method
在线阅读 下载PDF
EXACT ANALYTIC METHOD FG(?) SOLVING VARIABLE COEFFICIENT DIFFERENTIAL EQUATION
13
作者 纪振义 叶开源 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 1989年第10期885-896,共12页
Many engineering problems can be reduced to the solution of a variable coefficient differential equation. In this paper, the exact analytic method is suggested to solve variable coefficient differential equations unde... Many engineering problems can be reduced to the solution of a variable coefficient differential equation. In this paper, the exact analytic method is suggested to solve variable coefficient differential equations under arbitrary boundary condition. By this method, the general computation formal is obtained. Its convergence in proved. We can get analytic expressions which converge to exact solution and its higher order derivatives uniformy Four numerical examples are given, which indicate that satisfactory results can he obtanedby this method. 展开更多
关键词 SOLVING VARIABLE COEFFICIENT DIFFERENTIAL EQUATION exact ANALYTIC method FG
在线阅读 下载PDF
AN EXACT ELEMENT METHOD FOR PLANE PROBLEM
14
作者 叶开沅 纪振义 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 1990年第5期413-420,共8页
In this paper, based on the step reduction method[1] and exact analytic method[2] anew method-exact element method for constructing finite element, is presented. Since the new method doesn 't need the variational ... In this paper, based on the step reduction method[1] and exact analytic method[2] anew method-exact element method for constructing finite element, is presented. Since the new method doesn 't need the variational principle, it can be applied to solve non-positive and positive definite partial differential equations with arbitrary variable coefficient. By this method, a quadrilateral noncompatible element with 8 degrees of freedom is derived for the solution of plane problem. Since Jacobi's transformation is not applied, the present element may degenerate into a triangle element. It is convenient to use the element in engineering. In this paper, the convergence is proved. Numerical examples are given at the endof this paper, which indicate satisfactory results of stress and displacements can be obtained and have higher numerical precision in nodes. 展开更多
关键词 AN exact ELEMENT method FOR PLANE PROBLEM
在线阅读 下载PDF
AN EXACT ANALYTIC METHOD APPLIED TO NONHOMOGENEOUS RING-AND STRINGER-STIFFENED CYLINDRICAL SHELLS
15
作者 叶开源 纪振义 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 1989年第9期785-796,共12页
In this paper, the nonlinear axial symmetric deformation problem of nonhomogeneous ring- and stringer-stiffened shells is first solved by the exact analytic method. An analytic expression of displacements and stress r... In this paper, the nonlinear axial symmetric deformation problem of nonhomogeneous ring- and stringer-stiffened shells is first solved by the exact analytic method. An analytic expression of displacements and stress resultants is obtained and its convergence is proved. Displacements and stress resultants converge to exact solution uniformly. Finally, it is only necessary to solve a system of linear algebraic equations with two unknowns. Four numerical examples are given at the end of the paper which indicate that satisfactory results can be obtained by the exact analytic method. 展开更多
关键词 AN exact ANALYTIC method APPLIED TO NONHOMOGENEOUS RING-AND STRINGER-STIFFENED CYLINDRICAL SHELLS
在线阅读 下载PDF
Approximation-Exact Penalty Function Method for Solving a Class of Stochastic Programming
16
作者 Wang Guang-min, Wan Zhong-ping School of Mathematics and Statistics, Wuhan University, Wuhan 430072, Hubei, China 《Wuhan University Journal of Natural Sciences》 CAS 2003年第04A期1051-1056,共6页
We present an approximation-exact penalty function method for solving the single stage stochastic programming problem with continuous random variable. The original problem is transformed into a determinate nonlinear p... We present an approximation-exact penalty function method for solving the single stage stochastic programming problem with continuous random variable. The original problem is transformed into a determinate nonlinear programming problem with a discrete random variable sequence, which is obtained by some discrete method. We construct an exact penalty function and obtain an unconstrained optimization. It avoids the difficulty in solution by the rapid growing of the number of constraints for discrete precision. Under lenient conditions, we prove the equivalence of the minimum solution of penalty function and the solution of the determinate programming, and prove that the solution sequences of the discrete problem converge to a solution to the original problem. 展开更多
关键词 single stage stochastic programming discrete method exact penalty function CONVERGENCE
在线阅读 下载PDF
A Modified Thermodynamics Method to Generate Exact Solutions of Einstein Equations
17
作者 谭鸿威 杨锦波 +1 位作者 何唐梅 张靖仪 《Communications in Theoretical Physics》 SCIE CAS CSCD 2017年第1期41-46,共6页
We modify the method to generate the exact solutions of the Einstein equations basing on the laws of thermodynamics. Firstly, the Komar mass is used to take the place of the Misner-Sharp energy, which is used in the o... We modify the method to generate the exact solutions of the Einstein equations basing on the laws of thermodynamics. Firstly, the Komar mass is used to take the place of the Misner-Sharp energy, which is used in the original methods, and then several exact solutions of Einstein equations are obtained, including the black hole solution which is surrounded by quintessence. Moreover, the geometry surface gravity defined by Komar mass is also constructed.Secondly, we use both the Komar mass and the ADM mass to modify such method, and the similar results are obtained.Moreover, with some generalize addition to the definition of the ADM mass, our method can be generalized to global monopole spacetime. 展开更多
关键词 exact solutions modified thermodynamical method Komar mass ADM mass
原文传递
Exact Solutions of Two Nonlinear Partial Differential Equations by the First Integral Method 被引量:1
18
作者 Qingmei Zhang Mei Xiong Longwei Chen 《Advances in Pure Mathematics》 2020年第1期12-20,共9页
In recent years, many methods have been used to find the exact solutions of nonlinear partial differential equations. One of them is called the first integral method, which is based on the ring theory of commutative a... In recent years, many methods have been used to find the exact solutions of nonlinear partial differential equations. One of them is called the first integral method, which is based on the ring theory of commutative algebra. In this paper, exact travelling wave solutions of the Non-Boussinesq wavepacket model and the (2 + 1)-dimensional Zoomeron equation are studied by using the first integral method. From the solving process and results, the first integral method has the characteristics of simplicity, directness and effectiveness about solving the exact travelling wave solutions of nonlinear partial differential equations. In other words, tedious calculations can be avoided by Maple software;the solutions of more accurate and richer travelling wave solutions are obtained. Therefore, this method is an effective method for solving exact solutions of nonlinear partial differential equations. 展开更多
关键词 The First INTEGRAL method The PARTIAL Differential EQUATIONS The exact TRAVELLING Wave Solutions
在线阅读 下载PDF
A New Approach for the Exact Solutions of Nonlinear Equations of Fractional Order via Modified Simple Equation Method 被引量:1
19
作者 Muhammad Younis 《Applied Mathematics》 2014年第13期1927-1932,共6页
In this article, the modified simple equation method has been extended to celebrate the exact solutions of nonlinear partial time-space differential equations of fractional order. Firstly, the fractional complex trans... In this article, the modified simple equation method has been extended to celebrate the exact solutions of nonlinear partial time-space differential equations of fractional order. Firstly, the fractional complex transformation has been implemented to convert nonlinear partial fractional differential equations into nonlinear ordinary differential equations. Afterwards, modified simple equation method has been implemented, to find the exact solutions of these equations, in the sense of modified Riemann-Liouville derivative. For applications, the exact solutions of time-space fractional derivative Burgers’ equation and time-space fractional derivative foam drainage equation have been discussed. Moreover, it can also be concluded that the proposed method is easy, direct and concise as compared to other existing methods. 展开更多
关键词 exact Solutions Complex Transformation MODIFIED SIMPLE EQUATION method Nonlinear Equations of FRACTIONAL Order FRACTIONAL Calculus Theory
在线阅读 下载PDF
Exact Travelling Wave Solutions of Two Nonlinear Schr&#246;dinger Equations by Using Two Methods 被引量:1
20
作者 Qingmei Zhang Mei Xiong Longwei Chen 《Journal of Applied Mathematics and Physics》 2019年第12期3101-3115,共15页
The special kind of (G’/G)-expansion method and the new mapping method are easy and significant mathematical methods. In this paper, exact travelling wave solutions of the higher order dispersive Cubic-quintic nonlin... The special kind of (G’/G)-expansion method and the new mapping method are easy and significant mathematical methods. In this paper, exact travelling wave solutions of the higher order dispersive Cubic-quintic nonlinear Schr&#246;dinger equation and the generalized nonlinear Schr&#246;dinger equation are studied by using the two methods. Finally, the solitary wave solutions, singular soliton solutions, bright and dark soliton solutions and periodic solutions of the two nonlinear Schr&#246;dinger equations are obtained. The results show that this method is effective for solving exact solutions of nonlinear partial differential equations. 展开更多
关键词 The Special Kind of (G’/G)-Expansion method the New Mapping method the Partial Differential Equations the exact TRAVELLING Wave Solutions
在线阅读 下载PDF
上一页 1 2 59 下一页 到第
使用帮助 返回顶部