Tinnitus is a concerning condition that affects most adults worldwide,with a prevalence of 6.7%.Theories of tinnitus have explained that an increase in spontaneous neural activity at the level of the thalamus could in...Tinnitus is a concerning condition that affects most adults worldwide,with a prevalence of 6.7%.Theories of tinnitus have explained that an increase in spontaneous neural activity at the level of the thalamus could induce tinnitus.There are no standardized objective tests for tinnitus assessment because of its multifaceted nature.Hence,the current study aimed to explore the effect of Tinnitus on Latency and Amplitude of the Auditory Middle Latency Response in Audiological Attendees.The study recruited 50 individuals(25 normals and 25 individuals with tinnitus)who underwent audiological evaluations like Pure tone audiometry,immittance,pitch and loudness matching,THI and middle latency response.The IHS program was used to record MLR,which was obtained using tone burst stimuli of 500 Hz,1 KHz,2 KHz,and 4 KHz at a rate of 7.1/s with a constant duration of 5 ms,for a total of 1500 sweeps.As a covariate,pure tone thresholds were one of the variabilities that were addressed by ANCOVA.The amplitude of the Pa component varied significantly between the tinnitus and control groups,according to the MLR data and no other components of MLR reached that significance.Furthermore,there was no discernible variation in the latency or amplitude of MLR among any of the other components.The latency of the waveforms increased as the stimulus frequency increased.Karl Pearson correlation coefficient showed no significant correlation between THI scores and any of the outcome measures except for Pa amplitude.As the Pa component of MLR showed maximum changes between controls and individuals with tinnitus,the Pa component could be considered a potential tool for identifying neurophysiological changes related to tinnitus.展开更多
西方富国的科研人员进行了一些在我们看来多少有些“荒诞”的实验。本文就是一例。但是,细读之下,你不仅为其认真的实验态度所感动,而且,也会觉得“荒诞”之中也有不少“正经”因素。说不准,一项“荒诞”的实验引发了震惊世界的科研成果...西方富国的科研人员进行了一些在我们看来多少有些“荒诞”的实验。本文就是一例。但是,细读之下,你不仅为其认真的实验态度所感动,而且,也会觉得“荒诞”之中也有不少“正经”因素。说不准,一项“荒诞”的实验引发了震惊世界的科研成果!本文的标题理解起来不易,弄懂了标题,文章的中心思想也就在其中了。Odors Best at Evoking Emotionally Charged Memories可以完整地表达为:Odors are best at evoking memories which are emotionally charged.可译:气味最能激活与情感相连的记忆。本文的首句和标题呼应,值得玩味。展开更多
The laryngeal muscle evoked potential(LMEP)is a neurophysiological outcome parameter that guarantees integrity of the nerve-electrode interface during experiments with vagus nerve stimulation(VNS).This paper discusses...The laryngeal muscle evoked potential(LMEP)is a neurophysiological outcome parameter that guarantees integrity of the nerve-electrode interface during experiments with vagus nerve stimulation(VNS).This paper discusses a large series of minimally invasive LMEP recordings in 46 female Lewis rats,implanted with a custom-made VNS electrode around the left cervical vagus nerve.After a 3-week recovery,LMEPs were recorded twice in each animal,with swapping the anode and cathode positions of the VNS electrode(polarity inversion).A VNS-induced LMEP was identified as the initial negative peak wave post-stimulation artifact,consistently recorded in all sweeps at a given stimulation output current.Latency was defined as the time from stimulation onset to this negative peak,and stimulation threshold as the lowest current showing a clear and reproducible LMEP.An LMEP response was shown by 37/46 animals(80.4%),with stimulation intensity threshold of 0.37±0.27 mA and latency of 2.39±0.45 ms.Administering the cathodic pulse phase first at the caudal electrode contact resulted in the shortest LMEP latencies(MWU:p=0.049.2.36±0.43 ms vs.2.41±0.47 ms).Minimally invasive LMEP recording provides a feasible and reliable means for checking electrode functioning and correct implantation.展开更多
Objective:To assess the effectiveness of machine learning in automating the prediction of vestibular abnormalities after cochlear implantation(CI)in patients with sensorineural hearing loss(SNHL),with the goal of deve...Objective:To assess the effectiveness of machine learning in automating the prediction of vestibular abnormalities after cochlear implantation(CI)in patients with sensorineural hearing loss(SNHL),with the goal of developing a practical model that can accurately predict long-term vestibular function outcomes and identify associated risk factors.Methods:Clinical data,including imaging,vestibular evoked myogenic potentials(VEMPs),and auditory information,were collected from patients with sensorineural hearing loss(SNHL)before and after CI.The decision tree algorithm was employed to address missing values and screen pre-CI clinical features.Six machine learning methods were subsequently utilized to predict the relationships between the extracted features and post-CI vestibular dysfunction.The best-performing method determined the ranking of feature importance,which was regarded as risk factors for predicting symptoms and VEMPs results after CI.Results:Logistic regression models effectively predicted both post-CI vestibular dysfunction and abnormal cervical VEMP(c VEMP),with accuracies of 80%and 78%,respectively.The relative importance of the features,in descending order,was as follows:c VEMP latency,c VEMP amplitude,and residual hearing threshold.Moreover,the support vector machine(SVM)model attained an accuracy of 88%in predicting abnormal ocular VEMP(o VEMP)post-CI.For the SVM model,the feature importance ranking was as follows:o VEMP latency,o VEMP amplitude,and residual hearing threshold.Conclusions:This study successfully leverages machine learning techniques,specifically support vector machines(SVM)and logistic regression models,to predict the impact of CI on vestibular function.These predictive models provide valuable insights for presurgical planning and decision-making in CI procedures.Moreover,the findings highlight the critical risk factors associated with vestibular dysfunction,offering a robust reference for guiding vestibular rehabilitation strategies.展开更多
Objective: To study the relationship between cortical auditory evoked potential (CAEP) thresholds and behavioral thresholds in pediatric populations with sensorineural hearing loss (SNHL). Methods: Fifteen children (m...Objective: To study the relationship between cortical auditory evoked potential (CAEP) thresholds and behavioral thresholds in pediatric populations with sensorineural hearing loss (SNHL). Methods: Fifteen children (mean age 6.8 years) with bilateral SNHL underwent behavioral pure-tone audiometry and CAEP testing at 0.5, 1, 2, and 4 kHz. CAEP thresholds were determined using tone bursts, and correlations between CAEP and pure-tone thresholds were analyzed using Pearson correlation and t-tests. Results: A strong positive correlation was observed between P1 thresholds and behavioral thresholds across all test frequencies: 0.5 kHz (r = 0.765, p Conclusion: The strong correlation between P1 and behavioral thresholds demonstrates the reliability of CAEP testing for estimating auditory thresholds in children. These findings support the use of CAEP testing as a reliable objective tool for threshold estimation, particularly in cases where behavioral responses cannot be reliably obtained. When adjusted with frequency-specific correction values, CAEP testing provides a reliable method for assessing hearing thresholds in pediatric populations.展开更多
To the editor:Non-suicidal self-injury(NSSI)is an array of directly prepense or repetitive self-harm behaviours without suicidal intent.Individuals engage in self-injurious behaviours to reduce negative mental and cog...To the editor:Non-suicidal self-injury(NSSI)is an array of directly prepense or repetitive self-harm behaviours without suicidal intent.Individuals engage in self-injurious behaviours to reduce negative mental and cognitive states or evoke positive emotions.展开更多
Objective To observe the impacts of acupuncture on brainstem evoked potentials in the patients with primary depression. Methods Forty cases of primary depression were treated by acupuncture at Baihui （百会 GV 20）, Y...Objective To observe the impacts of acupuncture on brainstem evoked potentials in the patients with primary depression. Methods Forty cases of primary depression were treated by acupuncture at Baihui （百会 GV 20）, Yinatng （印堂 GV 29）, DazhuT （大椎 GV 14）, bilateral Shenmen （神门 HT 7）, bilateral Taichong （太冲 LR 3）, bilateral Neiguan （内关 PC 6） and SanyTnjiao （三阴交 SP 6）. The needles were retained for 30 min. Acupuncture treatment was given once every two days, three treatments a week. The brainstem auditory evoked potential （BAEP） and visual evoked potential （VEP） were observed in 6 weeks of treatment. The change in Hamilton depression scale （HAMD） score was observed before and after treatment in the depression group. Results After treatment, VEP wave latency was shortened significantly in patients of depression （P〈0.05）, BAEPIII wave latency was shortened significantly （P〈0.05）. The score of HAMD was decreased apparently in the depression group （P〈0.05）. Conclusions The stressability of visual and auditory stimuli in the central nervous system was decreased in the patients of depression. Acupuncture shortens remarkably the brainstem evoked potentials latency in the patients of depression and achieves the effective results in the treatment of primary depression.展开更多
Objective Early researches found that different heartbeat perceivers have different heartbeat evoked potential （HEP）waves.Two tasks were considered in our experiments to get more details about the differences betwee...Objective Early researches found that different heartbeat perceivers have different heartbeat evoked potential （HEP）waves.Two tasks were considered in our experiments to get more details about the differences between good and poor heartbeat perceivers at attention and resting state.Methods Thirty channels of electroencephalogram（EEG）were recorded in 22 subjects,who had been subdivided into good and poor heartbeat perceivers by mental tracking task. Principal component analysis（PCA）was applied to remove cardiac field artifact（CFA）from the HEP.Results（1）The good heart-beat perceivers showed difference between attention and resting state in the windows from 250 ms to 450 ms after R wave at C3 location and from 100 ms to 300 ms after R wave at C4 location;（2）The difference waveforms between good and poor heartbeat perceivers was a positive waveform at FZ from 220 ms to 340 ms after R wave,which was more significant in attention state.Conclusion Attention state had more effect on the HEPs of good heartbeat perceivers than that of poor heartbeat perceivers;and perception ability influenced HEPs more strongly in the attention state than in the resting state.展开更多
Objective:To observe the effects of perfusion of the gastrodin in abdominal aorta for alleviating the spinal cord ischemia reperfusion injury(SCIRI).Methods:A total of 36 New Zealand white rabbits were divided randoml...Objective:To observe the effects of perfusion of the gastrodin in abdominal aorta for alleviating the spinal cord ischemia reperfusion injury(SCIRI).Methods:A total of 36 New Zealand white rabbits were divided randomly into sham-operated group(group S),control group(group C) and gastrodin group(group G),12 rabbits for each group.Aorta abdominalis infrarenalis blocking method was applied to establish the SCIRI model.The changes of motor evoked potentials(MEPs) before the ischemia and on 30 min,60 min,6 h,12 h and 24 h of reperfusion of the gastrodin were respectively recorded,and the neurologic function score before the ischemia,on the 6 h,12 h and 24 h of the reperfusion of the gastrodin were assessed.And the changes of the concentration of serum neuron specific enolase(NSE),interleukin(IL)-l β and IL-8 were measured before the ischemia,after 45 min of ischemia,and on 30 min,60 min,6 h,12 h and 24 h of reperfusion of gastrodin.Then the levels of spinal cord nerve cells mitochondrial superoxide dismutase(SOD),reactive oxygen species(ROS),glutathione peroxidase(GSH-PX),malondialdehyde(MDA),total antioxidant capacity(T-AOC) and mitochondrial swelling degree(MSD) were tested and the histopathologic changes in spinal cord tissues were observed.Results:The levels of the NSE,IL-lfter the ischemβ,IL-8,ROS,MDA and MSD of group C were all significantly elevated aia(P<0.01);the levels of the spinal nerve cell mitochondria SOD,GSH-PX and T-AOC were all significantly reduced(P<0.01),MEPs and spinal cord tissue pathology were damaged significantly(P<0.01).The rate of motor neuron abnormalities and the damages of spinal cord tissue pathology of group G were significantly milder than those of group C(P<0.01);the levels of NSE,IL-lROS,MDA and MSD were significantly lower than those of group C(P< 0.01),but tβ,IL-8,he levels of SOD,GSH-PX and T-AOC were all significantly higher than those of group C(P<0.01),and the recovery of neurologic function score during the reperfusion of gastrodin was significantly faster than group C(P<0.01).Conclusions:Perfusion of the gastrodin in abdominal aorta can alleviate the spinal cord ischemiare perfusion injury by promoting the mitochondrial antioxidant capacity and inhibiting the inflammatory reaction.展开更多
文摘Tinnitus is a concerning condition that affects most adults worldwide,with a prevalence of 6.7%.Theories of tinnitus have explained that an increase in spontaneous neural activity at the level of the thalamus could induce tinnitus.There are no standardized objective tests for tinnitus assessment because of its multifaceted nature.Hence,the current study aimed to explore the effect of Tinnitus on Latency and Amplitude of the Auditory Middle Latency Response in Audiological Attendees.The study recruited 50 individuals(25 normals and 25 individuals with tinnitus)who underwent audiological evaluations like Pure tone audiometry,immittance,pitch and loudness matching,THI and middle latency response.The IHS program was used to record MLR,which was obtained using tone burst stimuli of 500 Hz,1 KHz,2 KHz,and 4 KHz at a rate of 7.1/s with a constant duration of 5 ms,for a total of 1500 sweeps.As a covariate,pure tone thresholds were one of the variabilities that were addressed by ANCOVA.The amplitude of the Pa component varied significantly between the tinnitus and control groups,according to the MLR data and no other components of MLR reached that significance.Furthermore,there was no discernible variation in the latency or amplitude of MLR among any of the other components.The latency of the waveforms increased as the stimulus frequency increased.Karl Pearson correlation coefficient showed no significant correlation between THI scores and any of the outcome measures except for Pa amplitude.As the Pa component of MLR showed maximum changes between controls and individuals with tinnitus,the Pa component could be considered a potential tool for identifying neurophysiological changes related to tinnitus.
文摘西方富国的科研人员进行了一些在我们看来多少有些“荒诞”的实验。本文就是一例。但是,细读之下,你不仅为其认真的实验态度所感动,而且,也会觉得“荒诞”之中也有不少“正经”因素。说不准,一项“荒诞”的实验引发了震惊世界的科研成果!本文的标题理解起来不易,弄懂了标题,文章的中心思想也就在其中了。Odors Best at Evoking Emotionally Charged Memories可以完整地表达为:Odors are best at evoking memories which are emotionally charged.可译:气味最能激活与情感相连的记忆。本文的首句和标题呼应,值得玩味。
基金The Research Foundation Flanders(FWO),Grant/Award Number:1S25620NThe Charcot Research Fund。
文摘The laryngeal muscle evoked potential(LMEP)is a neurophysiological outcome parameter that guarantees integrity of the nerve-electrode interface during experiments with vagus nerve stimulation(VNS).This paper discusses a large series of minimally invasive LMEP recordings in 46 female Lewis rats,implanted with a custom-made VNS electrode around the left cervical vagus nerve.After a 3-week recovery,LMEPs were recorded twice in each animal,with swapping the anode and cathode positions of the VNS electrode(polarity inversion).A VNS-induced LMEP was identified as the initial negative peak wave post-stimulation artifact,consistently recorded in all sweeps at a given stimulation output current.Latency was defined as the time from stimulation onset to this negative peak,and stimulation threshold as the lowest current showing a clear and reproducible LMEP.An LMEP response was shown by 37/46 animals(80.4%),with stimulation intensity threshold of 0.37±0.27 mA and latency of 2.39±0.45 ms.Administering the cathodic pulse phase first at the caudal electrode contact resulted in the shortest LMEP latencies(MWU:p=0.049.2.36±0.43 ms vs.2.41±0.47 ms).Minimally invasive LMEP recording provides a feasible and reliable means for checking electrode functioning and correct implantation.
基金a grant from the Beijing Hospitals Authority Youth Programme(grant:QML20230204)a grant from National Natural Science Foundation of China(No.82471179)a grant from the National Key Research and Development Plan(grant:2022YFC2402705)。
文摘Objective:To assess the effectiveness of machine learning in automating the prediction of vestibular abnormalities after cochlear implantation(CI)in patients with sensorineural hearing loss(SNHL),with the goal of developing a practical model that can accurately predict long-term vestibular function outcomes and identify associated risk factors.Methods:Clinical data,including imaging,vestibular evoked myogenic potentials(VEMPs),and auditory information,were collected from patients with sensorineural hearing loss(SNHL)before and after CI.The decision tree algorithm was employed to address missing values and screen pre-CI clinical features.Six machine learning methods were subsequently utilized to predict the relationships between the extracted features and post-CI vestibular dysfunction.The best-performing method determined the ranking of feature importance,which was regarded as risk factors for predicting symptoms and VEMPs results after CI.Results:Logistic regression models effectively predicted both post-CI vestibular dysfunction and abnormal cervical VEMP(c VEMP),with accuracies of 80%and 78%,respectively.The relative importance of the features,in descending order,was as follows:c VEMP latency,c VEMP amplitude,and residual hearing threshold.Moreover,the support vector machine(SVM)model attained an accuracy of 88%in predicting abnormal ocular VEMP(o VEMP)post-CI.For the SVM model,the feature importance ranking was as follows:o VEMP latency,o VEMP amplitude,and residual hearing threshold.Conclusions:This study successfully leverages machine learning techniques,specifically support vector machines(SVM)and logistic regression models,to predict the impact of CI on vestibular function.These predictive models provide valuable insights for presurgical planning and decision-making in CI procedures.Moreover,the findings highlight the critical risk factors associated with vestibular dysfunction,offering a robust reference for guiding vestibular rehabilitation strategies.
文摘Objective: To study the relationship between cortical auditory evoked potential (CAEP) thresholds and behavioral thresholds in pediatric populations with sensorineural hearing loss (SNHL). Methods: Fifteen children (mean age 6.8 years) with bilateral SNHL underwent behavioral pure-tone audiometry and CAEP testing at 0.5, 1, 2, and 4 kHz. CAEP thresholds were determined using tone bursts, and correlations between CAEP and pure-tone thresholds were analyzed using Pearson correlation and t-tests. Results: A strong positive correlation was observed between P1 thresholds and behavioral thresholds across all test frequencies: 0.5 kHz (r = 0.765, p Conclusion: The strong correlation between P1 and behavioral thresholds demonstrates the reliability of CAEP testing for estimating auditory thresholds in children. These findings support the use of CAEP testing as a reliable objective tool for threshold estimation, particularly in cases where behavioral responses cannot be reliably obtained. When adjusted with frequency-specific correction values, CAEP testing provides a reliable method for assessing hearing thresholds in pediatric populations.
基金the Innovation 2030-Major Project of Brain Science and Brain-lnspired Intelligence Technology(2021ZD0200600)Shanghai Science and Technology Committee(22YF1439100,YDZX20213100001003)National Natural Science Foundation of China(82201678).
文摘To the editor:Non-suicidal self-injury(NSSI)is an array of directly prepense or repetitive self-harm behaviours without suicidal intent.Individuals engage in self-injurious behaviours to reduce negative mental and cognitive states or evoke positive emotions.
文摘Objective To observe the impacts of acupuncture on brainstem evoked potentials in the patients with primary depression. Methods Forty cases of primary depression were treated by acupuncture at Baihui （百会 GV 20）, Yinatng （印堂 GV 29）, DazhuT （大椎 GV 14）, bilateral Shenmen （神门 HT 7）, bilateral Taichong （太冲 LR 3）, bilateral Neiguan （内关 PC 6） and SanyTnjiao （三阴交 SP 6）. The needles were retained for 30 min. Acupuncture treatment was given once every two days, three treatments a week. The brainstem auditory evoked potential （BAEP） and visual evoked potential （VEP） were observed in 6 weeks of treatment. The change in Hamilton depression scale （HAMD） score was observed before and after treatment in the depression group. Results After treatment, VEP wave latency was shortened significantly in patients of depression （P〈0.05）, BAEPIII wave latency was shortened significantly （P〈0.05）. The score of HAMD was decreased apparently in the depression group （P〈0.05）. Conclusions The stressability of visual and auditory stimuli in the central nervous system was decreased in the patients of depression. Acupuncture shortens remarkably the brainstem evoked potentials latency in the patients of depression and achieves the effective results in the treatment of primary depression.
基金the National Natural Science Foundation of China（No.30400105）；the National Basic Research Development Program（973）（No. 2003CB716106）；the National Science Fund for Distinguished Young Scholars of China（No.30525030）.
文摘Objective Early researches found that different heartbeat perceivers have different heartbeat evoked potential （HEP）waves.Two tasks were considered in our experiments to get more details about the differences between good and poor heartbeat perceivers at attention and resting state.Methods Thirty channels of electroencephalogram（EEG）were recorded in 22 subjects,who had been subdivided into good and poor heartbeat perceivers by mental tracking task. Principal component analysis（PCA）was applied to remove cardiac field artifact（CFA）from the HEP.Results（1）The good heart-beat perceivers showed difference between attention and resting state in the windows from 250 ms to 450 ms after R wave at C3 location and from 100 ms to 300 ms after R wave at C4 location;（2）The difference waveforms between good and poor heartbeat perceivers was a positive waveform at FZ from 220 ms to 340 ms after R wave,which was more significant in attention state.Conclusion Attention state had more effect on the HEPs of good heartbeat perceivers than that of poor heartbeat perceivers;and perception ability influenced HEPs more strongly in the attention state than in the resting state.
基金supported by National Natural Science Foundation of China (Grant number:30672025)Science and Technology Department of Guizhou Province Foundation Project (Grant number:Qinkehe SY[2013]3063,Qinheke J[2013]2179,Qinkehe LH[2014]7021)
文摘Objective:To observe the effects of perfusion of the gastrodin in abdominal aorta for alleviating the spinal cord ischemia reperfusion injury(SCIRI).Methods:A total of 36 New Zealand white rabbits were divided randomly into sham-operated group(group S),control group(group C) and gastrodin group(group G),12 rabbits for each group.Aorta abdominalis infrarenalis blocking method was applied to establish the SCIRI model.The changes of motor evoked potentials(MEPs) before the ischemia and on 30 min,60 min,6 h,12 h and 24 h of reperfusion of the gastrodin were respectively recorded,and the neurologic function score before the ischemia,on the 6 h,12 h and 24 h of the reperfusion of the gastrodin were assessed.And the changes of the concentration of serum neuron specific enolase(NSE),interleukin(IL)-l β and IL-8 were measured before the ischemia,after 45 min of ischemia,and on 30 min,60 min,6 h,12 h and 24 h of reperfusion of gastrodin.Then the levels of spinal cord nerve cells mitochondrial superoxide dismutase(SOD),reactive oxygen species(ROS),glutathione peroxidase(GSH-PX),malondialdehyde(MDA),total antioxidant capacity(T-AOC) and mitochondrial swelling degree(MSD) were tested and the histopathologic changes in spinal cord tissues were observed.Results:The levels of the NSE,IL-lfter the ischemβ,IL-8,ROS,MDA and MSD of group C were all significantly elevated aia(P<0.01);the levels of the spinal nerve cell mitochondria SOD,GSH-PX and T-AOC were all significantly reduced(P<0.01),MEPs and spinal cord tissue pathology were damaged significantly(P<0.01).The rate of motor neuron abnormalities and the damages of spinal cord tissue pathology of group G were significantly milder than those of group C(P<0.01);the levels of NSE,IL-lROS,MDA and MSD were significantly lower than those of group C(P< 0.01),but tβ,IL-8,he levels of SOD,GSH-PX and T-AOC were all significantly higher than those of group C(P<0.01),and the recovery of neurologic function score during the reperfusion of gastrodin was significantly faster than group C(P<0.01).Conclusions:Perfusion of the gastrodin in abdominal aorta can alleviate the spinal cord ischemiare perfusion injury by promoting the mitochondrial antioxidant capacity and inhibiting the inflammatory reaction.
