In their recent paper Pereira et al.(2025)claim that validation is overlooked in mapping and modelling of ecosystem services(ES).They state that“many studies lack critical evaluation of the results and no validation ...In their recent paper Pereira et al.(2025)claim that validation is overlooked in mapping and modelling of ecosystem services(ES).They state that“many studies lack critical evaluation of the results and no validation is provided”and that“the validation step is largely overlooked”.This assertion may have been true several years ago,for example,when Ochoa and Urbina-Cardona(2017)made a similar observation.However,there has been much work on ES model validation over the last decade.展开更多
BACKGROUND Timely and accurate evaluation of mental disorders in adolescents using appropriate mental health literacy assessment tools is essential for improving their mental health literacy levels.AIM To develop an e...BACKGROUND Timely and accurate evaluation of mental disorders in adolescents using appropriate mental health literacy assessment tools is essential for improving their mental health literacy levels.AIM To develop an evaluation index system for the mental health literacy of adolescent patients with mental disorders,providing a scientific,comprehensive,and reliable tool for the monitoring and intervention of mental health literacy of such patients.METHODS From December 2022 to June 2023,the evaluation index system for mental health literacy of adolescents with mental disorders was developed through literature reviews,semi-structured interviews,expert letter consultations,and the analytic hierarchy process.Based on this index system,a self-assessment questionnaire was compiled and administered to 305 adolescents with mental disorders to test the reliability and validity of the index system.RESULTS The final evaluation index system for mental health literacy of adolescents with mental disorders included 4 first-level indicators,10 second-level indicators,and 52 third-level indicators.The overall Cronbach’sαcoefficient of the index system was 0.957,with a partial reliability of 0.826 and a content validity index of 0.975.The cumulative variance contribution rate of 10 common factors was 66.491%.The correlation coefficients between each dimension and the total questionnaire ranged from 0.672 to 0.724,while the correlation coefficients in each dimension ranged from 0.389 to 0.705.CONCLUSION The evaluation index system for mental health literacy of adolescents with mental disorders,developed in this study,demonstrated notable reliability and validity,making it a valuable tool for evaluating mental health literacy in this population.展开更多
The construction of spot electricity markets plays a pivotal role in power system reforms,where market clearing systems profoundly influence market efficiency and security.Current clearing systems predominantly adopt ...The construction of spot electricity markets plays a pivotal role in power system reforms,where market clearing systems profoundly influence market efficiency and security.Current clearing systems predominantly adopt a single-system architecture,with research focusing primarily on accelerating solution algorithms through techniques such as high-efficiency parallel solvers and staggered decomposition of mixed-integer programming models.Notably absent are systematic studies evaluating the adaptability of primary-backup clearing systems incontingency scenarios—a critical gap given redundant systems’expanding applications in operational environments.This paper proposes a comprehensive evaluation framework for analyzing dual-system adaptability,demonstrated through an in-depth case study of the Inner Mongolia power market.First,we establish the innovative“Dual-Active Heterogeneous”architecture that enables independent parallelized operation and fault-isolated redundancy.Subsequently,key performance indices are quantitatively evaluated across four critical dimensions:unit commitment decisions,generator output constraints,transmission section congestion patterns,and clearing price formation mechanisms.An integrated fuzzy evaluation methodology incorporating grey relational analysis is employed for objective indicator weighting,enabling systematic quantification of system superiority under specific grid operating states.Empirical results based on actual operational data from 200 generation units demonstrate the framework’s efficacy in guiding optimal system selection,with particularly strong performance observed during peak load periods.The proposed approach shows high generalization potential for other regional markets employing redundant clearing mechanisms—particularly those with increasing renewable penetration and associated uncertainty.展开更多
In the present study,researchers examined a solar off-grid-connected photovoltaic system for a family house in the city of Baghdad.The design was created with the help of the“How to Design PV Program”and the“Renewa...In the present study,researchers examined a solar off-grid-connected photovoltaic system for a family house in the city of Baghdad.The design was created with the help of the“How to Design PV Program”and the“Renewable Energy Investment Calculator(REICAL)”software(Version 1.1).In Iraq,the national grid provides around 71%of the overall electricity demand,though this drops to nearly 50%during extremely hot and cold months,where the supply alternates between four hours on and four hours off.During the off periods,power is generated by local generators at high costs.To promote the adoption of photovoltaic solar systems among Iraqi citizens through loans,three options for meeting 100% of electricity needs have been proposed:an on-grid solution,a hybrid system that supplies 24 h,and an off-grid solution for a 24-h supply.The 12-h off-grid system(hybrid)is both economical and efficient for delivering electricity.Findings reveal that,over 20 years,the system’s output will amount to 141,176.71 kWh,with a payback period of 5.85 years and a performance ratio of 86.2%.Investment outcome data showed a net present value of $6445,and the profitability index was 6.16,indicating the project’s profitability.Additionally,the system could result in a net reduction of CO_(2) emissions totaling 132,810.24 kg.展开更多
Based on the generalized reduced R-matrix theory,the R-matrix analysis code(RAC program)was used to analyze the experimental data of all the nuclear reaction channels related to the 5 He system.The current calculation...Based on the generalized reduced R-matrix theory,the R-matrix analysis code(RAC program)was used to analyze the experimental data of all the nuclear reaction channels related to the 5 He system.The current calculations provide accurate and reliable evaluation data and are in good agreement with the experimental data.In this study,self-consistent evaluation data for each reaction were obtained using multi-channel and multi-energy fitting.In particular,the error propagation theory of generalized least squares was used to determine the error of the evaluation data and the covariance matrix of the integral cross section.This R-matrix analysis for the 5 He system has three features.First,for the first time,the error in the evaluation data of the T(d,n)^(4)He reaction cross section and the covariance matrix of the integral cross section are provided.Second,we used only one set of R-matrix parameters to depict the reaction cross section of each reaction channel of the 5 He system for the entire energy region in our work.Third,in this evaluation,we considered some of the latest measured experimental data,especially after 2000.The T(d,n)^(4)He reaction cross section at 0.1 MeV and below was carefully studied.The effect of different energy levels in T(d,n)^(4)He was analyzed,with the energy levels 3/2^(+)making a major contribution to the cross section,and the role of the S-wave and P-wave from 3/2~-determines the lean forward trend of the angular distributions at 0.01–0.1 MeV.展开更多
Pneumatic system has been widely used throughout industry, and it consumes more than billions kW h of electricity one year all over the world. So as to improve the efficiency of pneumatic system, its power evaluation ...Pneumatic system has been widely used throughout industry, and it consumes more than billions kW h of electricity one year all over the world. So as to improve the efficiency of pneumatic system, its power evaluation as well as measurement methods should be proposed, and their applicability should be validated. In this paper, firstly, power evaluation and measurement methods of pneumatic system were introduced for the first time. Secondly, based on the proposed methods, power distributions in pneumatic system was analyzed. Thirdly, through the analysis on pneumatic efficiencies of typical compressors and pneumatic components, the applicability of the proposed methods were validated. It can be concluded that, first of all, the proposed methods to evaluation and measurement the power of pneumatic system were efficient. Furthermore, the pneumatic power efficiencies of pneumatic system in the air production and cleaning procedure are respectively about 35%–75% and 85%–90%. Moreover, the pneumatic power efficiencies of pneumatic system in the transmission and consumption procedures are about 70%–85% and 10%–35%. And the total pneumatic power efficiency of pneumatic system is about 2%–20%, which varies largely with the system configuration. This paper provides a method to analyze and measure the power of pneumatic system, lay a foundation for the optimization and energy-saving design of pneumatic system.展开更多
Diversity in the biophysical and socio-economic attributes of agricultural systems makes them uniquely niche based. Farmers are expert in local biophysical and socio-economic situations and can contribute in developin...Diversity in the biophysical and socio-economic attributes of agricultural systems makes them uniquely niche based. Farmers are expert in local biophysical and socio-economic situations and can contribute in developing pragmatic indicators of agro-environmental development. During evaluation of an agricultural research project in Yunnan, China, local farmers were capable of evaluating the effects of modified technologies on existing cropping systems and discussed their attitudes to the interventions using their own indicators. Farmers＇ response can be grouped into seven major aspects： i） effects on income, ii） effects on production resources, iii） effects on crop management, iv） existing local knowledge about the technology, v） availability of inputs, vi） access to information, and vii） socio-economic conditions of farming households. Farmers concluded that environmental conditions in the experimental catchment in comparison to an adjacent untreated catchment were better in terms of soil and water losses, vegetation cover and natural resources, infrastructures and catchment management, use of environmentally-friendly technologies, and crop productivity. Success in soil and water conservation programmes depends on the efforts of the farmers and other local users and their greater involvement helps to identify more pragmatic indicators. Furthermore, it increases ownership of the programme, enhances interactions with the project scientists, increases farmers＇ awareness of ago-environmental problems and their possible consequences. These development will enable scientists to develop better targeted interventions and increase the likelihood of adoption of tested technologies by local communities. The use of paired adjacent catchments improved evaluation activities and is proposed as good practice for future catchment improvement programmes.展开更多
The accurate performance evaluation of a cutterhead is essential to improving cutterhead structure design and predicting project cost. Through extensive research, this paper evaluates the performance of a tunnel borin...The accurate performance evaluation of a cutterhead is essential to improving cutterhead structure design and predicting project cost. Through extensive research, this paper evaluates the performance of a tunnel boring machine(TBM) cutterhead for cutting ability and slagging ability. This paper propose cutting efficiency, stability, and continuity of slagging as the evaluation indexes of comprehensive cutterhead performance. On the basis of research of true TBM engineering applications, this paper proposes a calculation method for each index. A slagging efficiency index with a ratio of the maximum di erence between the slagging amount and average slagging is established. And a slagging stability index with a ratio of the maximum slagging fluctuation and average slagging is presented. Meanwhile, a cutting efficiency index by the weighed average value of multistage rock fragmentation of a cutter’s specific energy is established. The Robbins and China Railway Construction Corporation(CRCC) cutterheads are evaluated. The results show that under the same thrust and torque, the slagging stability of the CRCC scheme is worse, but the slagging continuity of the CRCC scheme is better. The cutting ability index shows that the CRCC cutterhead is more efficient.展开更多
Objective The renewable capacity is an important attribute of groundwater resources. Most previous studies have focused on the porous aquifer systems by the measurement and analysis of isotopes deuterium （D）, oxyge...Objective The renewable capacity is an important attribute of groundwater resources. Most previous studies have focused on the porous aquifer systems by the measurement and analysis of isotopes deuterium （D）, oxygen-18 （180）, tritium （3H）, and carbon-14 （14C） （Chen Zongyu et al., 2010; Bozdag and Gocmez, 2016）, and few studies have been conducted on karst groundwater systems. The major reason lies in the complexity of groundwater hydrogeological conditions in karst areas, and most of them are open systems. In this study, we selected the Pingyi-Feixian karst groundwater system in Shandong Province, northern China, as a typical study area in an attempt to evaluate the renewable capacity by 14C age and the δ13C mixing model. The spatial characteristics and spatial variability in renewable capacity of karst groundwater were further discussed, providing a reference for the exploitation of karst grotmdwater in the similar region.展开更多
BACKGROUND Small bowel obstruction(SBO)still imposes a substantial burden on the health care system.Traditional evaluation systems for SBO outcomes only focus on a single element.The comprehensive evaluation of outcom...BACKGROUND Small bowel obstruction(SBO)still imposes a substantial burden on the health care system.Traditional evaluation systems for SBO outcomes only focus on a single element.The comprehensive evaluation of outcomes for patients with SBO remains poorly studied.Early intensive clinical care would effectively improve the short-term outcomes for SBO,however,the full spectrum of the potential risk status regarding the high complication-cost burden is undetermined.AIM We aim to construct a novel system for the evaluation of SBO outcomes and the identification of potential risk status.METHODS Patients who were diagnosed with SBO were enrolled and stratified into the simple SBO(SiBO)group and the strangulated SBO(StBO)group.A principal component(PC)analysis was applied for data simplification and the extraction of patient characteristics,followed by separation of the high PC score group and the low PC score group.We identified independent risk status on admission via a binary logistic regression and then constructed predictive models for worsened management outcomes.Receiver operating characteristic curves were drawn,and the areas under the curve(AUCs)were calculated to assess the effectiveness of the predictive models.RESULTS Of the 281 patients,45 patients(16.0%)were found to have StBO,whereas 236 patients(84.0%)had SiBO.Regarding standardized length of stay(LOS),total hospital cost and the presence of severe adverse events(SAEs),a novel principal component was extracted(PC score=0.429×LOS+0.444×total hospital cost+0.291×SAE).In the multivariate analysis,risk statuses related to poor results for SiBO patients,including a low lymphocyte to monocyte ratio(OR=0.656),radiological features of a lack of small bowel feces signs(OR=0.316)and mural thickening(OR=1.338),were identified as risk factors.For the StBO group,higher BUN levels(OR=1.478)and lower lymphocytes levels(OR=0.071)were observed.The AUCs of the predictive models for poor outcomes were 0.715(95%CI:0.635-0.795)and 0.874(95%CI:0.762-0.986)for SiBO and StBO stratification,respectively.CONCLUSION The novel PC indicator provided a comprehensive scoring system for evaluating SBO outcomes on the foundation of complication-cost burden.According to the relative risk factors,early tailored intervention would improve the short-term outcomes.展开更多
In order to improve the public transit’s accessibility and promote service quality of the public transit,it is necessary to alleviate the“last⁃mile”problem.The combination of the public transit and bicycle⁃sharing ...In order to improve the public transit’s accessibility and promote service quality of the public transit,it is necessary to alleviate the“last⁃mile”problem.The combination of the public transit and bicycle⁃sharing system is competitive compared with the private car.In 2016,the dockless bicycle⁃sharing system has been undergoing tremendous development.Because the dockless bicycle⁃sharing system is different from previous bicycle⁃sharing systems,components of service quality of the dockless bicycle⁃sharing system differ.However,there are few articles about the service quality of the dockless bicycle⁃sharing system.This paper examined the evaluation of service quality of the dockless bicycle⁃sharing system along with a measurement of users’satisfaction.A questionnaire about service quality was designed,which includes 15 factors.Through the analysis of travelers’evaluation of factors of the dockless bicycle⁃sharing system with Rasch Model,these original ordinal data(Likert data)was transformed to the interval data:the person parameter(ability)and the item parameter(difficulty).Through the analysis of interviewees’abilities,it was found that only education and monthly consumption have significant influence on interviewees’evaluation of service quality of the dockless bicycle⁃sharing system,while there is no significant influence of gender,weekly use of dockless shared⁃bicycle,private car ownership,or monthly income on the evaluation.Furthermore,it was found that users were dissatisfied with cycling under the adverse weather,disturbance from pedestrians and cars,continuity of the bicycle lane,complaint channel,and staff service the most.展开更多
To improve the design and management of an integrated production system(IPS),a set of mathematical models and workflows are developed for evaluating the capacity of an IPS at steady-state conditions.Combining the cons...To improve the design and management of an integrated production system(IPS),a set of mathematical models and workflows are developed for evaluating the capacity of an IPS at steady-state conditions.Combining the conservation laws with applicable multiphase fluid and choke models,these mathematical models are solved to characterize the hydraulics of an integrated system of reservoir,wells,chokes,flowlines,and separator at steady state.The controllable variables such as well count,choke size and separator pressure are adjusted to optimize the performance of the IPs at a specific time.It is found that increasing the well count can increase the bulk flow rate of the production network,but too many wells may increase the manifold pressure,leading to decline of single-well production.Increasing the choke size can improve the capacity of the IPs.The production of the IPs is negatively correlated with the separator pressure.With increasing separator pressure and decreasing choke size,the increment of total fluid production(the capacity of IPS)induced by increasing well count decreases.Validation tests with field examples show a maximum absolute deviation is 1.5%,demonstrating the robustness and validity of the proposed mathematical models and workflows.展开更多
In the context of the digital transformation of vocational education,a quality evaluation index system has been constructed.Based on a questionnaire survey conducted among higher vocational colleges and enterprises in...In the context of the digital transformation of vocational education,a quality evaluation index system has been constructed.Based on a questionnaire survey conducted among higher vocational colleges and enterprises in Hainan Province,it has been found that the quality of vocational education generally depends on the talent training program and professional construction at the macro level.At the meso level,the teacher level and teaching environment are critical,while at the micro level,the evaluation of talent training quality cannot be underestimated.Strategies for quality improvement in vocational education are proposed from the perspectives of talent training programs,major construction,teacher development,teaching environment,and talent training quality,all under the lens of digital transformation.展开更多
China has abundant resources of hot dry rocks.However,due to the fact that the evaluation methods for favorable areas are mainly qualitative,and the evaluation indicators and standards are inconsistent,which restrict ...China has abundant resources of hot dry rocks.However,due to the fact that the evaluation methods for favorable areas are mainly qualitative,and the evaluation indicators and standards are inconsistent,which restrict the evaluation efficiency and exploration process of dry hot rocks.This paper is based on the understanding of the geologic features and genesis mechanisms of hot dry rocks in China and abroad.By integrating the main controlling factors of hot dry rock formation,and using index grading and quantification,the fuzzy hierarchical comprehensive method is applied to establish an evaluation system and standards for favorable areas of hot dry rocks.The evaluation system is based on four indicators:heat source,thermal channel,thermal reservoir and cap rock.It includes 11 evaluation parameters,including time of magmatic/volcanic activity,depth of molten mass or magma chamber,distribution of discordogenic faults,burial depth of thermal reservoir,cap rock type and thickness,surface thermal anomaly,heat flow,geothermal gradient,Moho depth,Curie depth,Earthquake magnitude and focal depth.Each parameter is divided into 3 levels.Applying this evaluation system to assess hot dry rock in central Inner Mongolia revealed that Class I favorable zones cover approximately 494 km^(2),while Class II favorable zones span about 5.7×10^(4) km^(2).The Jirgalangtu Sag and Honghaershute Sag in the Erlian Basin,along with Reshuitang Town in Keshiketeng Banner,Reshui Town in Ningcheng County,and Reshuitang Town in Aohan Banner of Chifeng City,are identified as Class I favorable zones for hot dry rock resources.These areas are characterized by high-temperature subsurface molten bodies or magma chambers serving as high-quality heat sources,shallow thermal reservoir depths,and overlying thick sedimentary rock layers acting as caprock.The establishment and application of the evaluation system for favorable areas of hot dry rock are expected to provide new approaches and scientific basis for guiding the practice of selecting hot dry rock areas in China.展开更多
Based on the educational evaluation reform,this study explores the construction of an evidence-based value-added evaluation system based on data-driven,aiming to solve the limitations of traditional evaluation methods...Based on the educational evaluation reform,this study explores the construction of an evidence-based value-added evaluation system based on data-driven,aiming to solve the limitations of traditional evaluation methods.The research adopts the method of combining theoretical analysis and practical application,and designs the evidence-based value-added evaluation framework,which includes the core elements of a multi-source heterogeneous data acquisition and processing system,a value-added evaluation agent based on a large model,and an evaluation implementation and application mechanism.Through empirical research verification,the evaluation system has remarkable effects in improving learning participation,promoting ability development,and supporting teaching decision-making,and provides a theoretical reference and practical path for educational evaluation reform in the new era.The research shows that the evidence-based value-added evaluation system based on data-driven can reflect students’actual progress more fairly and objectively by accurately measuring the difference in starting point and development range of students,and provide strong support for the realization of high-quality education development.展开更多
In underground mining,especially in entry-type excavations,the instability of surrounding rock structures can lead to incalculable losses.As a crucial tool for stability analysis in entry-type excavations,the critical...In underground mining,especially in entry-type excavations,the instability of surrounding rock structures can lead to incalculable losses.As a crucial tool for stability analysis in entry-type excavations,the critical span graph must be updated to meet more stringent engineering requirements.Given this,this study introduces the support vector machine(SVM),along with multiple ensemble(bagging,adaptive boosting,and stacking)and optimization(Harris hawks optimization(HHO),cuckoo search(CS))techniques,to overcome the limitations of the traditional methods.The analysis indicates that the hybrid model combining SVM,bagging,and CS strategies has a good prediction performance,and its test accuracy reaches 0.86.Furthermore,the partition scheme of the critical span graph is adjusted based on the CS-BSVM model and 399 cases.Compared with previous empirical or semi-empirical methods,the new model overcomes the interference of subjective factors and possesses higher interpretability.Since relying solely on one technology cannot ensure prediction credibility,this study further introduces genetic programming(GP)and kriging interpolation techniques.The explicit expressions derived through GP can offer the stability probability value,and the kriging technique can provide interpolated definitions for two new subclasses.Finally,a prediction platform is developed based on the above three approaches,which can rapidly provide engineering feedback.展开更多
Natural gas hydrate(NGH),as a widely recognized clean energy,has shown a significant resource potential.However,due to the lack of a unified evaluation methodology and the difficult determination of key parameters,the...Natural gas hydrate(NGH),as a widely recognized clean energy,has shown a significant resource potential.However,due to the lack of a unified evaluation methodology and the difficult determination of key parameters,the evaluation results of global NGH resource are greatly different.This paper establishes a quantitative relationship between NGH resource potential and conventional oil and gas resource and a NGH resource evaluation model based on the whole petroleum system(WPS)and through the analysis of dynamic field controlling hydrocarbon accumulation.The global NGH initially in-place and recoverable resources are inverted through the Monte Carlo simulation,and verified by using the volume analogy method based on drilling results and the trend analysis method of previous evaluation results.The proposed evaluation model considers two genetic mechanisms of natural gas(biological degradation and thermal degradation),surface volume conversion factor difference between conventional natural gas and NGH,and the impacts of differences in favorable distribution area and thickness and in other aspects on the results of NGH resource evaluation.The study shows that the global NGH initially in-place and recoverable resources are 99×10^(12) m^(3) and 30×10^(12) m3,with averages of 214×10^(12) m^(3) and 68×10^(12) m^(3),respectively,less than 5% of the total conventional oil and gas resources,and they can be used as a supplement for the future energy of the world.The proposed NGH resource evaluation model creates a new option of evaluation method and technology,and generates reliable data of NGH resource according to the reliability comprehensive analysis and test,providing a parameter basis for subsequent NGH exploration and development.展开更多
Sand production and high water content in oil wells are two major challenges that restrict high and stable production in loose sandstone reservoirs.In this paper,nano SiO_(2),coupling agent triethoxysilane,phenolic re...Sand production and high water content in oil wells are two major challenges that restrict high and stable production in loose sandstone reservoirs.In this paper,nano SiO_(2),coupling agent triethoxysilane,phenolic resin and n-octanol were used to synthesize the main agent SCA-2.Hexamethylenetetramine and vinyl carbonate were selected to prepare the curing agent YGA-1,which was then compounded with SCA-2 to develop a sand fixation and water plugging system.Firstly,single-factor experiments were conducted to determine the optimal concentrations of SCA-2 and YGA-1,subsequently,the system’s sand fixation and water blocking performance were evaluated.Finally,a pilot test was carried out in the mining site.Experimental results showed that the optimal formula composition of the system was 10%SCA-2+5%YGA-1.The gelation time of the system was 180 minutes and the viscosity after gelation could reach 108.4 mPa·s.When the dosage of the drug system was 0.6 PV,the sand production rate remained below 0.08%.Dual-tube parallel experiments showed that the sand fixation and water plugging system had a water flow channel plugging rate of 87.5%,while the oil flow channel plugging rate was only 11.3%,indicating minimal damage to the oil-bearing reservoir.The field test showed that after the measures taken in Well M of X oilfield,the sand free oil recovery period exceeded 360 days,the water content decreased by 5.0%and the cumulative oil production increased by 7092 m^(3).This study provides new ideas for efficient development of loose sandstone reservoirs.展开更多
BACKGROUND Despite the developments in the field of kidney transplantation,the already existing diagnostic techniques for patient monitoring are considered insufficient.Protein biomarkers that can be derived from mode...BACKGROUND Despite the developments in the field of kidney transplantation,the already existing diagnostic techniques for patient monitoring are considered insufficient.Protein biomarkers that can be derived from modern approaches of proteomic analysis of liquid biopsies(serum,urine)represent a promising innovation in the monitoring of kidney transplant recipients.AIM To investigate the diagnostic utility of protein biomarkers derived from proteomics approaches in renal allograft assessment.METHODS A systematic review was conducted in accordance with PRISMA guidelines,based on research results from the PubMed and Scopus databases.The primary focus was on evaluating the role of biomarkers in the non-invasive diagnosis of transplant-related com-plications.Eligibility criteria included protein biomarkers and urine and blood samples,while exclusion criteria were language other than English and the use of low resolution and sensitivity methods.The selected research articles,were categorized based on the biological sample,condition and methodology and the significantly and reproducibly differentiated proteins were manually selected and extracted.Functional and network analysis of the selected proteins was performed.RESULTS In 17 included studies,58 proteins were studied,with the cytokine CXCL10 being the most investigated.Biological pathways related to immune response and fibrosis have shown to be enriched.Applications of biomarkers for the assessment of renal damage as well as the prediction of short-term and long-term function of the graft were reported.Overall,all studies have shown satisfactory diagnostic accuracy of proteins alone or in combination with conventional methods,as far as renal graft assessment is concerned.CONCLUSION Our review suggests that protein biomarkers,evaluated in specific biological fluids,can make a significant contribution to the timely,valid and non-invasive assessment of kidney graft.展开更多
Objective To systematically evaluate the overall characteristics and quality of literature on economic evaluation of drugs for type 2 diabetes,and to provide recommendations for future research and related decision-ma...Objective To systematically evaluate the overall characteristics and quality of literature on economic evaluation of drugs for type 2 diabetes,and to provide recommendations for future research and related decision-making.Methods The economic evaluation literature on drugs for type 2 diabetes based on the Chinese population were searched from CNKI,Wanfang,VIP and PubMed databases.The literature that met the inclusion criteria was selected,and the key research elements were extracted.Meanwhile,the quality of health economics studies(QHES)was used to evaluate the quality of the literature.Results and Conclusion A total of 325 articles(296 in Chinese and 29 in English)were included.Most of the studies were conducted by medical institutions(247 articles,76.0%)and they used cost-effectiveness analysis(295 articles,90.8%).However,most of the included literature did not report study perspective(267 articles,90.2%).The average QHES score of the included literature was 57.29,and the quality of the literature was concentrated in“low quality”(123 articles,37.8%)and“average quality”(138 articles,42.5%).Literature published in English journals,or using modeling methods,or from universities had relatively higher quality.The quality of economic evaluation literature on drugs for type 2 diabetes based on the Chinese population is generally low at present.There are many problems,such as single research institutions and methods,lack of research perspectives,and no sensitivity analysis.展开更多
文摘In their recent paper Pereira et al.(2025)claim that validation is overlooked in mapping and modelling of ecosystem services(ES).They state that“many studies lack critical evaluation of the results and no validation is provided”and that“the validation step is largely overlooked”.This assertion may have been true several years ago,for example,when Ochoa and Urbina-Cardona(2017)made a similar observation.However,there has been much work on ES model validation over the last decade.
基金Supported by Inter Disciplinary Direction Cultivation Project of Hunan University of Chinese Medicine,No.2025JC01032025 Hunan Province Science and Technology Innovation Plan Project,No.2025RC9012+2 种基金2022"Unveiling and Leading"Project of Discipline Construction at Hunan University of Chinese Medicine,No.22JBZ044Changsha Municipal Natural Science Foundation,No.kq2402174Hunan Provincial Science Popularization Fund Project,No.2025ZK4223.
文摘BACKGROUND Timely and accurate evaluation of mental disorders in adolescents using appropriate mental health literacy assessment tools is essential for improving their mental health literacy levels.AIM To develop an evaluation index system for the mental health literacy of adolescent patients with mental disorders,providing a scientific,comprehensive,and reliable tool for the monitoring and intervention of mental health literacy of such patients.METHODS From December 2022 to June 2023,the evaluation index system for mental health literacy of adolescents with mental disorders was developed through literature reviews,semi-structured interviews,expert letter consultations,and the analytic hierarchy process.Based on this index system,a self-assessment questionnaire was compiled and administered to 305 adolescents with mental disorders to test the reliability and validity of the index system.RESULTS The final evaluation index system for mental health literacy of adolescents with mental disorders included 4 first-level indicators,10 second-level indicators,and 52 third-level indicators.The overall Cronbach’sαcoefficient of the index system was 0.957,with a partial reliability of 0.826 and a content validity index of 0.975.The cumulative variance contribution rate of 10 common factors was 66.491%.The correlation coefficients between each dimension and the total questionnaire ranged from 0.672 to 0.724,while the correlation coefficients in each dimension ranged from 0.389 to 0.705.CONCLUSION The evaluation index system for mental health literacy of adolescents with mental disorders,developed in this study,demonstrated notable reliability and validity,making it a valuable tool for evaluating mental health literacy in this population.
基金supported by NARI Relays Electric Co.,Ltd.under the Project“Research on Evaluation of Clearing Results and Switching Criteria for Primary-Backup Systems in Electricity SpotMarkets”(Project No.CGSQ240800443).
文摘The construction of spot electricity markets plays a pivotal role in power system reforms,where market clearing systems profoundly influence market efficiency and security.Current clearing systems predominantly adopt a single-system architecture,with research focusing primarily on accelerating solution algorithms through techniques such as high-efficiency parallel solvers and staggered decomposition of mixed-integer programming models.Notably absent are systematic studies evaluating the adaptability of primary-backup clearing systems incontingency scenarios—a critical gap given redundant systems’expanding applications in operational environments.This paper proposes a comprehensive evaluation framework for analyzing dual-system adaptability,demonstrated through an in-depth case study of the Inner Mongolia power market.First,we establish the innovative“Dual-Active Heterogeneous”architecture that enables independent parallelized operation and fault-isolated redundancy.Subsequently,key performance indices are quantitatively evaluated across four critical dimensions:unit commitment decisions,generator output constraints,transmission section congestion patterns,and clearing price formation mechanisms.An integrated fuzzy evaluation methodology incorporating grey relational analysis is employed for objective indicator weighting,enabling systematic quantification of system superiority under specific grid operating states.Empirical results based on actual operational data from 200 generation units demonstrate the framework’s efficacy in guiding optimal system selection,with particularly strong performance observed during peak load periods.The proposed approach shows high generalization potential for other regional markets employing redundant clearing mechanisms—particularly those with increasing renewable penetration and associated uncertainty.
文摘In the present study,researchers examined a solar off-grid-connected photovoltaic system for a family house in the city of Baghdad.The design was created with the help of the“How to Design PV Program”and the“Renewable Energy Investment Calculator(REICAL)”software(Version 1.1).In Iraq,the national grid provides around 71%of the overall electricity demand,though this drops to nearly 50%during extremely hot and cold months,where the supply alternates between four hours on and four hours off.During the off periods,power is generated by local generators at high costs.To promote the adoption of photovoltaic solar systems among Iraqi citizens through loans,three options for meeting 100% of electricity needs have been proposed:an on-grid solution,a hybrid system that supplies 24 h,and an off-grid solution for a 24-h supply.The 12-h off-grid system(hybrid)is both economical and efficient for delivering electricity.Findings reveal that,over 20 years,the system’s output will amount to 141,176.71 kWh,with a payback period of 5.85 years and a performance ratio of 86.2%.Investment outcome data showed a net present value of $6445,and the profitability index was 6.16,indicating the project’s profitability.Additionally,the system could result in a net reduction of CO_(2) emissions totaling 132,810.24 kg.
基金supported by Science Challenge Project(No.TZ20180001)。
文摘Based on the generalized reduced R-matrix theory,the R-matrix analysis code(RAC program)was used to analyze the experimental data of all the nuclear reaction channels related to the 5 He system.The current calculations provide accurate and reliable evaluation data and are in good agreement with the experimental data.In this study,self-consistent evaluation data for each reaction were obtained using multi-channel and multi-energy fitting.In particular,the error propagation theory of generalized least squares was used to determine the error of the evaluation data and the covariance matrix of the integral cross section.This R-matrix analysis for the 5 He system has three features.First,for the first time,the error in the evaluation data of the T(d,n)^(4)He reaction cross section and the covariance matrix of the integral cross section are provided.Second,we used only one set of R-matrix parameters to depict the reaction cross section of each reaction channel of the 5 He system for the entire energy region in our work.Third,in this evaluation,we considered some of the latest measured experimental data,especially after 2000.The T(d,n)^(4)He reaction cross section at 0.1 MeV and below was carefully studied.The effect of different energy levels in T(d,n)^(4)He was analyzed,with the energy levels 3/2^(+)making a major contribution to the cross section,and the role of the S-wave and P-wave from 3/2~-determines the lean forward trend of the angular distributions at 0.01–0.1 MeV.
基金Supported by National Natural Science Foundation of China(Grants Nos.51675020,51375028)Open Foundation of the State Key Laboratory of Fluid Power and Mechatronic Systems
文摘Pneumatic system has been widely used throughout industry, and it consumes more than billions kW h of electricity one year all over the world. So as to improve the efficiency of pneumatic system, its power evaluation as well as measurement methods should be proposed, and their applicability should be validated. In this paper, firstly, power evaluation and measurement methods of pneumatic system were introduced for the first time. Secondly, based on the proposed methods, power distributions in pneumatic system was analyzed. Thirdly, through the analysis on pneumatic efficiencies of typical compressors and pneumatic components, the applicability of the proposed methods were validated. It can be concluded that, first of all, the proposed methods to evaluation and measurement the power of pneumatic system were efficient. Furthermore, the pneumatic power efficiencies of pneumatic system in the air production and cleaning procedure are respectively about 35%–75% and 85%–90%. Moreover, the pneumatic power efficiencies of pneumatic system in the transmission and consumption procedures are about 70%–85% and 10%–35%. And the total pneumatic power efficiency of pneumatic system is about 2%–20%, which varies largely with the system configuration. This paper provides a method to analyze and measure the power of pneumatic system, lay a foundation for the optimization and energy-saving design of pneumatic system.
基金Project supported by the University of Wolverhampton, UK.
文摘Diversity in the biophysical and socio-economic attributes of agricultural systems makes them uniquely niche based. Farmers are expert in local biophysical and socio-economic situations and can contribute in developing pragmatic indicators of agro-environmental development. During evaluation of an agricultural research project in Yunnan, China, local farmers were capable of evaluating the effects of modified technologies on existing cropping systems and discussed their attitudes to the interventions using their own indicators. Farmers＇ response can be grouped into seven major aspects： i） effects on income, ii） effects on production resources, iii） effects on crop management, iv） existing local knowledge about the technology, v） availability of inputs, vi） access to information, and vii） socio-economic conditions of farming households. Farmers concluded that environmental conditions in the experimental catchment in comparison to an adjacent untreated catchment were better in terms of soil and water losses, vegetation cover and natural resources, infrastructures and catchment management, use of environmentally-friendly technologies, and crop productivity. Success in soil and water conservation programmes depends on the efforts of the farmers and other local users and their greater involvement helps to identify more pragmatic indicators. Furthermore, it increases ownership of the programme, enhances interactions with the project scientists, increases farmers＇ awareness of ago-environmental problems and their possible consequences. These development will enable scientists to develop better targeted interventions and increase the likelihood of adoption of tested technologies by local communities. The use of paired adjacent catchments improved evaluation activities and is proposed as good practice for future catchment improvement programmes.
基金Supported by National basic research program of China(973 Project,Grant No.2013CB035400)National Natural Science Foundation of China(Grant No.51375001)+1 种基金Major Projects of Liaoning Science and Technology Plan(Grant No.2015106016)Basic Research Project of Central University(Grant No.DUT16QY11)
文摘The accurate performance evaluation of a cutterhead is essential to improving cutterhead structure design and predicting project cost. Through extensive research, this paper evaluates the performance of a tunnel boring machine(TBM) cutterhead for cutting ability and slagging ability. This paper propose cutting efficiency, stability, and continuity of slagging as the evaluation indexes of comprehensive cutterhead performance. On the basis of research of true TBM engineering applications, this paper proposes a calculation method for each index. A slagging efficiency index with a ratio of the maximum di erence between the slagging amount and average slagging is established. And a slagging stability index with a ratio of the maximum slagging fluctuation and average slagging is presented. Meanwhile, a cutting efficiency index by the weighed average value of multistage rock fragmentation of a cutter’s specific energy is established. The Robbins and China Railway Construction Corporation(CRCC) cutterheads are evaluated. The results show that under the same thrust and torque, the slagging stability of the CRCC scheme is worse, but the slagging continuity of the CRCC scheme is better. The cutting ability index shows that the CRCC cutterhead is more efficient.
基金funded by the National Natural Science Foundation of China(grant No.41502253)the National Key Research and Development Project(grant No.2017YFC0406106)
文摘Objective The renewable capacity is an important attribute of groundwater resources. Most previous studies have focused on the porous aquifer systems by the measurement and analysis of isotopes deuterium （D）, oxygen-18 （180）, tritium （3H）, and carbon-14 （14C） （Chen Zongyu et al., 2010; Bozdag and Gocmez, 2016）, and few studies have been conducted on karst groundwater systems. The major reason lies in the complexity of groundwater hydrogeological conditions in karst areas, and most of them are open systems. In this study, we selected the Pingyi-Feixian karst groundwater system in Shandong Province, northern China, as a typical study area in an attempt to evaluate the renewable capacity by 14C age and the δ13C mixing model. The spatial characteristics and spatial variability in renewable capacity of karst groundwater were further discussed, providing a reference for the exploitation of karst grotmdwater in the similar region.
基金Supported by Joint Funds for the innovation of science and Technology,Fujian Province,No.2018Y9054Young and Middle-Aged Talents Backbone Program of Fujian Province,No.2020GGA034The Construction Project of Fujian Province Minimally Invasive Medical Center,No.[2021]76.
文摘BACKGROUND Small bowel obstruction(SBO)still imposes a substantial burden on the health care system.Traditional evaluation systems for SBO outcomes only focus on a single element.The comprehensive evaluation of outcomes for patients with SBO remains poorly studied.Early intensive clinical care would effectively improve the short-term outcomes for SBO,however,the full spectrum of the potential risk status regarding the high complication-cost burden is undetermined.AIM We aim to construct a novel system for the evaluation of SBO outcomes and the identification of potential risk status.METHODS Patients who were diagnosed with SBO were enrolled and stratified into the simple SBO(SiBO)group and the strangulated SBO(StBO)group.A principal component(PC)analysis was applied for data simplification and the extraction of patient characteristics,followed by separation of the high PC score group and the low PC score group.We identified independent risk status on admission via a binary logistic regression and then constructed predictive models for worsened management outcomes.Receiver operating characteristic curves were drawn,and the areas under the curve(AUCs)were calculated to assess the effectiveness of the predictive models.RESULTS Of the 281 patients,45 patients(16.0%)were found to have StBO,whereas 236 patients(84.0%)had SiBO.Regarding standardized length of stay(LOS),total hospital cost and the presence of severe adverse events(SAEs),a novel principal component was extracted(PC score=0.429×LOS+0.444×total hospital cost+0.291×SAE).In the multivariate analysis,risk statuses related to poor results for SiBO patients,including a low lymphocyte to monocyte ratio(OR=0.656),radiological features of a lack of small bowel feces signs(OR=0.316)and mural thickening(OR=1.338),were identified as risk factors.For the StBO group,higher BUN levels(OR=1.478)and lower lymphocytes levels(OR=0.071)were observed.The AUCs of the predictive models for poor outcomes were 0.715(95%CI:0.635-0.795)and 0.874(95%CI:0.762-0.986)for SiBO and StBO stratification,respectively.CONCLUSION The novel PC indicator provided a comprehensive scoring system for evaluating SBO outcomes on the foundation of complication-cost burden.According to the relative risk factors,early tailored intervention would improve the short-term outcomes.
基金Sponsored by the National Natural Science Foundation of China(Grant No.51578247)
文摘In order to improve the public transit’s accessibility and promote service quality of the public transit,it is necessary to alleviate the“last⁃mile”problem.The combination of the public transit and bicycle⁃sharing system is competitive compared with the private car.In 2016,the dockless bicycle⁃sharing system has been undergoing tremendous development.Because the dockless bicycle⁃sharing system is different from previous bicycle⁃sharing systems,components of service quality of the dockless bicycle⁃sharing system differ.However,there are few articles about the service quality of the dockless bicycle⁃sharing system.This paper examined the evaluation of service quality of the dockless bicycle⁃sharing system along with a measurement of users’satisfaction.A questionnaire about service quality was designed,which includes 15 factors.Through the analysis of travelers’evaluation of factors of the dockless bicycle⁃sharing system with Rasch Model,these original ordinal data(Likert data)was transformed to the interval data:the person parameter(ability)and the item parameter(difficulty).Through the analysis of interviewees’abilities,it was found that only education and monthly consumption have significant influence on interviewees’evaluation of service quality of the dockless bicycle⁃sharing system,while there is no significant influence of gender,weekly use of dockless shared⁃bicycle,private car ownership,or monthly income on the evaluation.Furthermore,it was found that users were dissatisfied with cycling under the adverse weather,disturbance from pedestrians and cars,continuity of the bicycle lane,complaint channel,and staff service the most.
文摘To improve the design and management of an integrated production system(IPS),a set of mathematical models and workflows are developed for evaluating the capacity of an IPS at steady-state conditions.Combining the conservation laws with applicable multiphase fluid and choke models,these mathematical models are solved to characterize the hydraulics of an integrated system of reservoir,wells,chokes,flowlines,and separator at steady state.The controllable variables such as well count,choke size and separator pressure are adjusted to optimize the performance of the IPs at a specific time.It is found that increasing the well count can increase the bulk flow rate of the production network,but too many wells may increase the manifold pressure,leading to decline of single-well production.Increasing the choke size can improve the capacity of the IPs.The production of the IPs is negatively correlated with the separator pressure.With increasing separator pressure and decreasing choke size,the increment of total fluid production(the capacity of IPS)induced by increasing well count decreases.Validation tests with field examples show a maximum absolute deviation is 1.5%,demonstrating the robustness and validity of the proposed mathematical models and workflows.
文摘In the context of the digital transformation of vocational education,a quality evaluation index system has been constructed.Based on a questionnaire survey conducted among higher vocational colleges and enterprises in Hainan Province,it has been found that the quality of vocational education generally depends on the talent training program and professional construction at the macro level.At the meso level,the teacher level and teaching environment are critical,while at the micro level,the evaluation of talent training quality cannot be underestimated.Strategies for quality improvement in vocational education are proposed from the perspectives of talent training programs,major construction,teacher development,teaching environment,and talent training quality,all under the lens of digital transformation.
基金Supported by PetroChina Prospective and Basic Technological Project(2022DJ5503).
文摘China has abundant resources of hot dry rocks.However,due to the fact that the evaluation methods for favorable areas are mainly qualitative,and the evaluation indicators and standards are inconsistent,which restrict the evaluation efficiency and exploration process of dry hot rocks.This paper is based on the understanding of the geologic features and genesis mechanisms of hot dry rocks in China and abroad.By integrating the main controlling factors of hot dry rock formation,and using index grading and quantification,the fuzzy hierarchical comprehensive method is applied to establish an evaluation system and standards for favorable areas of hot dry rocks.The evaluation system is based on four indicators:heat source,thermal channel,thermal reservoir and cap rock.It includes 11 evaluation parameters,including time of magmatic/volcanic activity,depth of molten mass or magma chamber,distribution of discordogenic faults,burial depth of thermal reservoir,cap rock type and thickness,surface thermal anomaly,heat flow,geothermal gradient,Moho depth,Curie depth,Earthquake magnitude and focal depth.Each parameter is divided into 3 levels.Applying this evaluation system to assess hot dry rock in central Inner Mongolia revealed that Class I favorable zones cover approximately 494 km^(2),while Class II favorable zones span about 5.7×10^(4) km^(2).The Jirgalangtu Sag and Honghaershute Sag in the Erlian Basin,along with Reshuitang Town in Keshiketeng Banner,Reshui Town in Ningcheng County,and Reshuitang Town in Aohan Banner of Chifeng City,are identified as Class I favorable zones for hot dry rock resources.These areas are characterized by high-temperature subsurface molten bodies or magma chambers serving as high-quality heat sources,shallow thermal reservoir depths,and overlying thick sedimentary rock layers acting as caprock.The establishment and application of the evaluation system for favorable areas of hot dry rock are expected to provide new approaches and scientific basis for guiding the practice of selecting hot dry rock areas in China.
基金This paper is the research result of“Research on Innovation of Evidence-Based Teaching Paradigm in Vocational Education under the Background of New Quality Productivity”(2024JXQ176)the Shandong Province Artificial Intelligence Education Research Project(SDDJ202501035),which explores the application of artificial intelligence big models in student value-added evaluation from an evidence-based perspective。
文摘Based on the educational evaluation reform,this study explores the construction of an evidence-based value-added evaluation system based on data-driven,aiming to solve the limitations of traditional evaluation methods.The research adopts the method of combining theoretical analysis and practical application,and designs the evidence-based value-added evaluation framework,which includes the core elements of a multi-source heterogeneous data acquisition and processing system,a value-added evaluation agent based on a large model,and an evaluation implementation and application mechanism.Through empirical research verification,the evaluation system has remarkable effects in improving learning participation,promoting ability development,and supporting teaching decision-making,and provides a theoretical reference and practical path for educational evaluation reform in the new era.The research shows that the evidence-based value-added evaluation system based on data-driven can reflect students’actual progress more fairly and objectively by accurately measuring the difference in starting point and development range of students,and provide strong support for the realization of high-quality education development.
基金supported by the National Natural Science Foundation of China(Grant No.42177164)the Distinguished Youth Science Foundation of Hunan Province of China(Grant No.2022JJ10073)the Outstanding Youth Project of Hunan Provincial Department of Education,China(Grant No.23B0008).
文摘In underground mining,especially in entry-type excavations,the instability of surrounding rock structures can lead to incalculable losses.As a crucial tool for stability analysis in entry-type excavations,the critical span graph must be updated to meet more stringent engineering requirements.Given this,this study introduces the support vector machine(SVM),along with multiple ensemble(bagging,adaptive boosting,and stacking)and optimization(Harris hawks optimization(HHO),cuckoo search(CS))techniques,to overcome the limitations of the traditional methods.The analysis indicates that the hybrid model combining SVM,bagging,and CS strategies has a good prediction performance,and its test accuracy reaches 0.86.Furthermore,the partition scheme of the critical span graph is adjusted based on the CS-BSVM model and 399 cases.Compared with previous empirical or semi-empirical methods,the new model overcomes the interference of subjective factors and possesses higher interpretability.Since relying solely on one technology cannot ensure prediction credibility,this study further introduces genetic programming(GP)and kriging interpolation techniques.The explicit expressions derived through GP can offer the stability probability value,and the kriging technique can provide interpolated definitions for two new subclasses.Finally,a prediction platform is developed based on the above three approaches,which can rapidly provide engineering feedback.
基金Supported by the Major Consultation Project of the Chinese Academy of Sciences(2019-ZW11-Z-035)Technology Development Project of PetroChina Research Institute of Petroleum Exploration&Development(2021DJ0101)。
文摘Natural gas hydrate(NGH),as a widely recognized clean energy,has shown a significant resource potential.However,due to the lack of a unified evaluation methodology and the difficult determination of key parameters,the evaluation results of global NGH resource are greatly different.This paper establishes a quantitative relationship between NGH resource potential and conventional oil and gas resource and a NGH resource evaluation model based on the whole petroleum system(WPS)and through the analysis of dynamic field controlling hydrocarbon accumulation.The global NGH initially in-place and recoverable resources are inverted through the Monte Carlo simulation,and verified by using the volume analogy method based on drilling results and the trend analysis method of previous evaluation results.The proposed evaluation model considers two genetic mechanisms of natural gas(biological degradation and thermal degradation),surface volume conversion factor difference between conventional natural gas and NGH,and the impacts of differences in favorable distribution area and thickness and in other aspects on the results of NGH resource evaluation.The study shows that the global NGH initially in-place and recoverable resources are 99×10^(12) m^(3) and 30×10^(12) m3,with averages of 214×10^(12) m^(3) and 68×10^(12) m^(3),respectively,less than 5% of the total conventional oil and gas resources,and they can be used as a supplement for the future energy of the world.The proposed NGH resource evaluation model creates a new option of evaluation method and technology,and generates reliable data of NGH resource according to the reliability comprehensive analysis and test,providing a parameter basis for subsequent NGH exploration and development.
文摘Sand production and high water content in oil wells are two major challenges that restrict high and stable production in loose sandstone reservoirs.In this paper,nano SiO_(2),coupling agent triethoxysilane,phenolic resin and n-octanol were used to synthesize the main agent SCA-2.Hexamethylenetetramine and vinyl carbonate were selected to prepare the curing agent YGA-1,which was then compounded with SCA-2 to develop a sand fixation and water plugging system.Firstly,single-factor experiments were conducted to determine the optimal concentrations of SCA-2 and YGA-1,subsequently,the system’s sand fixation and water blocking performance were evaluated.Finally,a pilot test was carried out in the mining site.Experimental results showed that the optimal formula composition of the system was 10%SCA-2+5%YGA-1.The gelation time of the system was 180 minutes and the viscosity after gelation could reach 108.4 mPa·s.When the dosage of the drug system was 0.6 PV,the sand production rate remained below 0.08%.Dual-tube parallel experiments showed that the sand fixation and water plugging system had a water flow channel plugging rate of 87.5%,while the oil flow channel plugging rate was only 11.3%,indicating minimal damage to the oil-bearing reservoir.The field test showed that after the measures taken in Well M of X oilfield,the sand free oil recovery period exceeded 360 days,the water content decreased by 5.0%and the cumulative oil production increased by 7092 m^(3).This study provides new ideas for efficient development of loose sandstone reservoirs.
文摘BACKGROUND Despite the developments in the field of kidney transplantation,the already existing diagnostic techniques for patient monitoring are considered insufficient.Protein biomarkers that can be derived from modern approaches of proteomic analysis of liquid biopsies(serum,urine)represent a promising innovation in the monitoring of kidney transplant recipients.AIM To investigate the diagnostic utility of protein biomarkers derived from proteomics approaches in renal allograft assessment.METHODS A systematic review was conducted in accordance with PRISMA guidelines,based on research results from the PubMed and Scopus databases.The primary focus was on evaluating the role of biomarkers in the non-invasive diagnosis of transplant-related com-plications.Eligibility criteria included protein biomarkers and urine and blood samples,while exclusion criteria were language other than English and the use of low resolution and sensitivity methods.The selected research articles,were categorized based on the biological sample,condition and methodology and the significantly and reproducibly differentiated proteins were manually selected and extracted.Functional and network analysis of the selected proteins was performed.RESULTS In 17 included studies,58 proteins were studied,with the cytokine CXCL10 being the most investigated.Biological pathways related to immune response and fibrosis have shown to be enriched.Applications of biomarkers for the assessment of renal damage as well as the prediction of short-term and long-term function of the graft were reported.Overall,all studies have shown satisfactory diagnostic accuracy of proteins alone or in combination with conventional methods,as far as renal graft assessment is concerned.CONCLUSION Our review suggests that protein biomarkers,evaluated in specific biological fluids,can make a significant contribution to the timely,valid and non-invasive assessment of kidney graft.
文摘Objective To systematically evaluate the overall characteristics and quality of literature on economic evaluation of drugs for type 2 diabetes,and to provide recommendations for future research and related decision-making.Methods The economic evaluation literature on drugs for type 2 diabetes based on the Chinese population were searched from CNKI,Wanfang,VIP and PubMed databases.The literature that met the inclusion criteria was selected,and the key research elements were extracted.Meanwhile,the quality of health economics studies(QHES)was used to evaluate the quality of the literature.Results and Conclusion A total of 325 articles(296 in Chinese and 29 in English)were included.Most of the studies were conducted by medical institutions(247 articles,76.0%)and they used cost-effectiveness analysis(295 articles,90.8%).However,most of the included literature did not report study perspective(267 articles,90.2%).The average QHES score of the included literature was 57.29,and the quality of the literature was concentrated in“low quality”(123 articles,37.8%)and“average quality”(138 articles,42.5%).Literature published in English journals,or using modeling methods,or from universities had relatively higher quality.The quality of economic evaluation literature on drugs for type 2 diabetes based on the Chinese population is generally low at present.There are many problems,such as single research institutions and methods,lack of research perspectives,and no sensitivity analysis.
