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Real world studies are essential for drug therapy in Parkinson's disease
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作者 Thomas Müller 《Neural Regeneration Research》 SCIE CAS CSCD 2018年第9期1544-1545,共2页
Prospective real-world data from large patient samples,which re-port on the long-term effectiveness of the employed different drug therapies,are rare in Parkinson's disease(PD).The non interven-tional"Transde... Prospective real-world data from large patient samples,which re-port on the long-term effectiveness of the employed different drug therapies,are rare in Parkinson's disease(PD).The non interven-tional"Transdermal Rotigotine User Surveillance Study"(TRUST)trial represents such a real-world study.It investigated long-term treatment with different dopamine substituting treatment regimens in 2195 PD patients(Mfiller et al.,2018).Participation in TRUST meant that the treating neurologists were only asked to document and modify the dopaminergic drug regimen without any prior PD patient selection criteria.Thus this unique trial design reflects the real world of patient maintenance. 展开更多
关键词 RCT Real world studies are essential for drug therapy in Parkinson’s disease PDQ
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Study:Sleep Essential for Creativity
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作者 William McCall 陈裕珍 《当代外语研究》 2004年第3期12-13,共2页
[提示]只要你是脑力劳动者,或是本科生,硕士生,博士生,此文对你的作用绝对不可小看。本文的标题,一语道破了文章之主旨:思维之创造性来自充足的睡眠: Problem-solving appear to be directly linked to adequate sleep. Sleep is often ... [提示]只要你是脑力劳动者,或是本科生,硕士生,博士生,此文对你的作用绝对不可小看。本文的标题,一语道破了文章之主旨:思维之创造性来自充足的睡眠: Problem-solving appear to be directly linked to adequate sleep. Sleep is often the best medicine. Creativity also appears to be enhanced in the process. Sleep can help to turn yesterday’s problem into today’s solution. 偌大校园,子夜时分,寝室里照样灯火通明,学子仍然谈笑风生,黎明时刻,寝室里照样鼾声四起,学子仍然独步梦境,这是何等令人揪心的场景!须知,你们的思维创造力就流失于此! 展开更多
关键词 study:Sleep essential for Creativity
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Mass transfer mechanisms in fixed-bed adsorption of erythromycin 被引量:2
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作者 Ying SUN Jiawen ZHU +2 位作者 Kui CHEN Sheng ZHU Jie XU 《Frontiers of Chemical Science and Engineering》 SCIE EI CSCD 2008年第4期353-360,共8页
The equilibrium and kinetic characteristics of the adsorption of erythromycin to Sepabeads SP825 were determined.The equilibrium data in a batch system was well described by a Langmuir isotherm.The separation performa... The equilibrium and kinetic characteristics of the adsorption of erythromycin to Sepabeads SP825 were determined.The equilibrium data in a batch system was well described by a Langmuir isotherm.The separation performance was investigated in a fixed-bed system with respect to the adsorption superficial velocity,ionic strength and pH.A mathematical model was used to simulate the mass transfer mechanism,taking film mass transfer,pore diffusion and axial dispersion into account.The model predictions were consistent with the experi-mental data and were consequently used to determine the mass transfer coefficients. 展开更多
关键词 fixed-bed adsorption superficial velocity ionic strength erythromycin However investigations on the parameters governing the performance of this technology are still scarce.In the present work a polymeric and porous resin Sepabeads SP825 resin was used for its higher adsorption efficiency compared with the resins reported.The equilib-rium capacity of Sepabeads SP825 for EM in a batch system was established using a Langmuir isotherm.The effects of superficial velocity ionic strength and pH on the adsorption process were determined from the results of fixed bed experiments.And a model of the purification process was used to simulate the mass transfer mechanism which has taken film mass transfer pore diffusion and axial dispersion into account.The experimental adsorp-tion measurements were compared to the results calcu-lated from the model.The completion of these studies provide some essential parameters which are required in order to design a successful purification process and better understand the fundamentals of these process.
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