Notch1 is a mechanosensitive endothelial receptor that responds to vascular wall shear stress.However,data on Notch1 activity in humans remains limited,particularly regarding its role in endothelial function.Objective...Notch1 is a mechanosensitive endothelial receptor that responds to vascular wall shear stress.However,data on Notch1 activity in humans remains limited,particularly regarding its role in endothelial function.Objectives:Accordingly,the purpose of this study was to determine whether Notch1 is associated with the flow-mediated dilatory(FMD)response and whether it is related to aerobic fitness.A secondary purpose was to determine whether Notch1 is related to concentrations of vascular endothelial growth factor(VEGF).Methods:Sixteen(8M/8F)young(20-30 yrs old)and healthy(BMI:25±4.2 kg/m^(2),blood pressure:117±11.63/69±11.25 mmHg)adults participated in the study.Aerobic fitness was determined by cycle VO_(2) peak.An FMDwas performed on the brachial artery,and blood samples were taken from an antecubital vein at rest(baseline)and 1min after cuff deflation(to align with peak vessel dilation).Concentrations of Notch1 extracellular domain(NECD)and VEGFwere determined from plasma using enzyme-linked immunosorbent assays.Results:In contrast to our hypothesis,concentrations of NECD and VEGF did not change throughout the FMDandwere unrelated to allometrically scaled FMD values(p all>0.05).Likewise,there was no relationship between changes inNECD and VEGF(p=0.331,r=0.127).However,the change in NECD across the FMD was moderately(r=0.515)and significantly(p=0.024)correlated with VO_(2) peak.Conclusions:These novel data indicate that in healthy young adults,Notch1 activity is linked to aerobic fitness but may not be acutely involved in the shear-mediated vasodilatory response.展开更多
Objective: To report outcomes of balloon dilation Eustachian tuboplasty combined with tympanostomy tube insertion and middle ear pressure equalization therapy in treatment of recurrent secretory otitis media. Methods:...Objective: To report outcomes of balloon dilation Eustachian tuboplasty combined with tympanostomy tube insertion and middle ear pressure equalization therapy in treatment of recurrent secretory otitis media. Methods: Fifty one patients with recurrent secretory otitis media (62 ears) underwent balloon dilation of Eustachian tube and tympanic tube insertion under general anesthesia, followed by long term middle ear pressure equalization therapies. The Eustachian tube score (ETS) and Eustachian tube function questionnaire (ETDQ-7) were used for pre- and postoperative (up to 12 months) evaluation of Eustachian tube functions. Results: The mean ETS score was 2.34 ± 0.97 preoperatively, and 6.17 ± 1.54, 7.23 ± 1.62, 8.24 ± 1.97, and 7.63 ± 1.86 at 1, 3, 6 and 12 months postoperatively, respectively (P < 0.05). The ETDQ-7 score was 4.82 ± 1.07 preoperatively, and 2.20 ± 0.54, 2.32 ± 0.68, 2.53 ± 0.79, and 2.67 ± 0.76 at 1, 3, 6 and 12 months postoperatively, respectively (P < 0.05). Conclusion: Balloon dilation of Eustachian tube combined with tympanostomy and catheterization resulted in significant improvement of subjective symptoms and objective evaluation of Eustachian tube functions in most patients with recurrent secretory otitis media, as indicated by the ETS and ETDQ-7 scores, demonstrating high levels of efficacy and patient satisfaction.展开更多
Green＇s functions for Blot＇s dynamic equation in the frequency domain can be a highly useful tool for the investigation of dynamic responses of a saturated porous medium. Its applications are found in soil dynamics,...Green＇s functions for Blot＇s dynamic equation in the frequency domain can be a highly useful tool for the investigation of dynamic responses of a saturated porous medium. Its applications are found in soil dynamics, seismology, earthquake engineering, rock mechanics, geophysics, and acoustics. However, the mathematical work for deriving it can be daunting. Green＇s functions have been presented utilizing an analogy between the dynamic thermoelasticity and the dynamic poroelasticity in the frequency domain using the u-p formulation. In this work, a special term ＂decoupling coefficient＂ for the decomposition of the fast and slow dilatational waves is proposed and expressed to present a new methodology for deriving the poroelastodynamic Green＇s functions. The correct- ness of the solution is demonstrated by numerically comparing the current solution with Cheng＇s previous solution. The separation of the two waves in the present methodology allows the more accurate evaluation of Green＇s functions, particularly the solution of the slow dilatational wave. This can be advantageous for the numerical implementation of the boundary element method （BEM） and other applications.展开更多
Objective Dilated cardiomyopathy(DCM) is generally considered to be accompanied by both left and right ventricular dysfunction,but most studies only analyze the left ventricular function. In this study,we evaluated th...Objective Dilated cardiomyopathy(DCM) is generally considered to be accompanied by both left and right ventricular dysfunction,but most studies only analyze the left ventricular function. In this study,we evaluated the effect of arotinolol on right ventricular function in patients with DCM. Methods Right ventricular ejection fraction(RVEF) and right ventricular diameter(RVD) were measured by two-dimensional echocardiography(2-DE) in 33 DCM patients;RVEF measured by first-pass radionuclide angiography(FPRA) was compared with that by 2-DE. Results The treatment with arotinolol for one year resulted in a reduction in the right ventricular diameter(baseline,23.0 ± 8.3 mm vs after one-year treatment,20.7 ± 5.4 mm;P=0.004 ) and an associated increase in ejection fraction(baseline,36.9 ± 10.3% vs after one-year treatment,45.8 ± 9.6%;P < 0.001 ) ;there is a high correlation between the 2-DE method and radionuclide ventriculographic method. The correlation coefficient is 0.933(P<0.001) . Conclusion Arotinolol therapy could not only improve left ventricular function,but also improve right ventricular function in DCM patients.展开更多
Objective To evaluate the efficacy and safety of long-term treatment with arotinolol in patients with idiopathic dilated cardiomyopathy(IDCM).Methods Sixty-three patients with IDCM were evaluated at baseline and after...Objective To evaluate the efficacy and safety of long-term treatment with arotinolol in patients with idiopathic dilated cardiomyopathy(IDCM).Methods Sixty-three patients with IDCM were evaluated at baseline and after 12-month therapy with arotinolol.The conventional therapy for congestive heart failure was continued throughout the study with arotinolol as the only β-blocker.Left ventricular function was assessed with the New York Heart Association functional class and two-dimensional echocardiography.Results After 12-month arotinolol treatment,there was a significant improvement in left ventricular systolic function.Left ventricular end-systolic dimension significantly decreased from 59.52±8.83 mm to 50.89±8.17 mm(P<0.001).Left ventricular ejection fraction significantly increased from 27.39%±7.94% to 41.13%±9.45%(P<0.001).Left ventricular mass index decreased from 150.47±42.42 g/m2 to 141.58±34.36 g/m2(P<0.01).No adverse events leading to premature discontinuation of study drug occurred.Conclusion In this preliminary study,12-month arotinolol treatment has a favorable effect on left ventricular function in patients with IDCM,and it is safe and well tolerated.展开更多
Objective: Dysphagia is a frequent symptom caused by cerebral infarction. This study investigated the effect evaluation and safety of electroacupuncture combined with balloon dilatation on dysphagia after cerebral inf...Objective: Dysphagia is a frequent symptom caused by cerebral infarction. This study investigated the effect evaluation and safety of electroacupuncture combined with balloon dilatation on dysphagia after cerebral infarction. Methods: Totally 100 patients with dysphagia after cerebral infarction were enrolled as study subjects and assigned into the control group (treated with balloon dilatation) and the observation group (treated with electroacupuncture and balloon dilatation), with 50 cases in each group. The general data of participants were recorded. Before or after treatment, swallowing function was assessed by water swallow test, standardized swallowing function assessment (SSA), videofluoroscopic swallow study (VFSS), and functional oral intake scale (FOIS). The cerebral hemodynamics, serological indicators, neurological impairment, quality of life (QOL) score were analyzed. Additionally, the occurrence of complications and adverse reactions after treatment was assessed. Results: There was no significant difference in gender, age, BMI, course of disease, and grade of dysphagia between the two groups. Balloon dilatation alone and electroacupuncture combined with balloon dilatation decreased the water swallow test, SSA, and VFSS scores, increased FOIS score, and improved the swallowing function, cerebral hemodynamic parameters, serological indicators, neurological function and QOL, with the better efficacy in the combined therapy. Moreover, combined therapy had lower incidences of complications and adverse reactions than balloon dilatation therapy alone. Conclusion: Electroacupuncture intervention combined with balloon dilatation therapy ameliorates swallowing function, cerebral hemodynamics, serological indicators, neurological function and QOL, and reduces complications and adverse reactions in dysphagia after cerebral infarction.展开更多
To assess the left ventricle regional systolic and diastolic function, left ventricle geometry and left venticle sphericity indexes in patients with dilated cardiomyopathy （DCM） by quantitative tissue velocity imagi...To assess the left ventricle regional systolic and diastolic function, left ventricle geometry and left venticle sphericity indexes in patients with dilated cardiomyopathy （DCM） by quantitative tissue velocity imaging （QTVI）. Methods Thirty normal subjects and 52 DCM patients underwent QTVI and colour Doppler flow imaging study in order to measure the left ventricular regional function along left ventricle apical long-axis view and the left ventricle geometry. Peak tissue velocities of left venticle regional muscular tissue during systole （ Vs）, systolic acceleration （ a）, early diastole（Ve） and left atrium contraction（Va） along left venticle apical long axis view were measured. The indexes of left ventricular regional systolic and diastolic function were mearsured at the same time. The left ventricle geometry shape was reflected from the systolic and diastolic sphericity index （Sis and Sid）, the left ventricular ejection fraction （LVEF） and D wave / A wave （PVd/PVa） of pulmonary veins flowing spectrum reflected the global left ventricular systolic and diastolic function. The Vs, Ve, Va, a, PVd/PVa ratio, LVEF, Sis, Sid and their correlations between normal subjects and patients with DCM were compared and analyzed. Results Vs, Ve, Va, a, PVd/PVa, Sis and Sid in patients with DCM were lower than those in normal persons. There were significant relations between Sis and a （ r = 0. 6142, P 〈 0. 05）, Ve/Va and Sid （ r = 0. 6271, P 〈 0. 05 ）. Conclusions QTVI offer a newer method which has a higher sensitivity and accuracy in evaluating the left venticle regional systolic and diastolic function in DCM patients. There was significant relation between regional cardiac function and left venticle sphericity. （ S Chin J Cardiol 2009; 10（1） ： 9 -14）展开更多
Background: The aim of this study was to determine the relation of left atrial (LA) volume and LA volume index with left ventricular function and to determine the association of duration of symptoms and left atrial vo...Background: The aim of this study was to determine the relation of left atrial (LA) volume and LA volume index with left ventricular function and to determine the association of duration of symptoms and left atrial volume index in patients with dilated cardiomyopathy. Materials and Methods: This was an observational, single centre study conducted in India. A total of 50 patients who were admitted to department of cardiology from July, 2008 to February, 2009 with diagnosis of dilated cardiomyopathy and an ejection fraction of <40% were included. Results: Of the 50 patients, 34 (68%) were males. 27 (54%) patients were in NYHA class II and 23 (46%) patients were in NYHA class III. LA volume was found to be ≥40 ml in all patients. LV function and LA volume were found to be correlated (r = -0.789, p < 0.01). Similarly, there was a correlation between LV function and LA volume index (r = -0.826, p < 0.01). There was no correlation between LA volume index and duration of symptoms (r = 0.04). Conclusion: It can be concluded that there is a strong inverse correlation between LA volume and left ventricular function and also between LA volume index and left ventricular function. The patients with NYHA class III were having larger left atrial volume than those with NYHA class II. Moreover, the duration of symptoms has no correlation with left atrial volume index.展开更多
Stress-dilatancy relationship or plastic potential function are crucial components of every elastoplastic constitutive model developed for sand or cemented sand.This is because the associated flow rule usually does no...Stress-dilatancy relationship or plastic potential function are crucial components of every elastoplastic constitutive model developed for sand or cemented sand.This is because the associated flow rule usually does not produce acceptable outcomes for sand or cemented sand.Many formulas have been introduced based on the experimental observations in conventional and advanced plasticity models in order to capture ratio of plastic volumetric strain increment to plastic deviatoric strain increment(i.e.dilatancy rate).Lack of an article that gathers these formulas is clear in the literature.Thus,this paper is an attempt to summarize plastic potentials and specially stress-dilatancy relations so far proposed for constitutive modelling of cohesionless and cemented sands.Stress-dilatancy relation is usually not the same under compression and extension conditions.Furthermore,it may also be different under loading and unloading conditions.Therefore,the focus in this paper mainly places on the proposed stress-dilatancy relations for compressive monotonic loading.Moreover because plastic potential function can be calculated by integration of stress-dilatancy relationship,more weight is allocated to stress-dilatancy relationship in this research.展开更多
In this paper, we prove that the control function of the dilatation function of Beurling-Ahlfors extension is convex. Using the quasi-symmetric function ρ, we get a relatively sharp estimate of the dilatation functio...In this paper, we prove that the control function of the dilatation function of Beurling-Ahlfors extension is convex. Using the quasi-symmetric function ρ, we get a relatively sharp estimate of the dilatation function: D(x,y)≤ 17/32 (ρ(x, y) + 1) (ρ(x + y/2, y/2) +ρ(x - y/2, y/2) +2) , which improves the results before. We also show that the above result is asymptotically precise.展开更多
Cardiovascular magnetic resonance (CMR) has become a reference standard for the measure-ment of cardiac volumes, function, and mass. This study aims to reconstruct three dimen-sional modeling of the left ventricle (LV...Cardiovascular magnetic resonance (CMR) has become a reference standard for the measure-ment of cardiac volumes, function, and mass. This study aims to reconstruct three dimen-sional modeling of the left ventricle (LV) in pa-tients with heart failure (HF) using CMRtools and thereby derive the LV functional indices. CMR images were acquired in 41 subjects (6 females) with heart failure (HF) and 12 normal controls (4 females). Five comparisons were made (i) nor-mal and dilated heart failure subjects, (ii) male and female normal heart, (iii) male and female dilated heart, (iv) male normal and dilated heart failure and (v) female normal and dilated heart failure. In HF, a significant higher values of EDV (320 刡 79 vs. 126 刡 22 ml, P&amp;amp;amp;amp;lt;0.0001), ESV (255 刡 68 vs. 54 刡 12 ml, P&amp;amp;amp;amp;lt;0.00001) and lower values of EF (20 刡 7 vs. 58 刡 5 %) were found compared that of normal control. There were significant difference on LV EDV and ESV between sex in both normal and HF subjects.展开更多
Objective:To investigate the effect of metoprolol on cardiac function and prognosis in patients with dilated cardiomyopathy.Methods:100 patients with dilated cardiomyopathy treated in our hospital from January 2018 to...Objective:To investigate the effect of metoprolol on cardiac function and prognosis in patients with dilated cardiomyopathy.Methods:100 patients with dilated cardiomyopathy treated in our hospital from January 2018 to December 2019 were randomly divided into control group(n=50)and observation group(n=50).The control group was treated with conventional methods,and the observation group was treated with conventional methods and metoprolol for 6 months.The cardiac function[left ventricular ejection fraction(LVEF),stroke volume(SV),cardiac output(CO)]and prognosis[Glasgow Outcome Scale(GOS)score]of the two groups before and at the end of 6 months of intervention were compared,and the incidence of adverse reactions of the two groups were compared.Results:After 6 months of treatment,the levels of LVEF,SV and CO in the two groups were higher than before treatment,and the comparison level between the observation group and the control group was higher,the difference was statistically significant(P<0.05);After 6 months of treatment,the GOS score of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05);There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Metoprolol can improve the cardiac function and prognosis of patients with dilated cardiomyopathy,without increasing the incidence of adverse reactions.展开更多
Objective To compare the different effects of endothelia progenitor cells （ EPCs ） or basic fibroblast growth factor （b-FGF） intromyocardial infusion on cardiac function and neovascularization for dilated cardiomy...Objective To compare the different effects of endothelia progenitor cells （ EPCs ） or basic fibroblast growth factor （b-FGF） intromyocardial infusion on cardiac function and neovascularization for dilated cardiomyopathy（ DCM） rats. Methods Fifty adult female rats received inguinal subcutaneous injections of isoproterenol （ISO, 250 mg/kg） for induction of DCM. Four weeks later, the model rats were randomly divided into EPCs group, b-FGF group and control group. The 2×106 EPCs （ resolved in 100 μL PBS） , 100 μL b-FGF （ lO0 μg/mL ） and 100 μL PBS were evenly transplanted into the myocardium of EPCs group, b-FGF group and control group, respectively. Three months later, echocardiographic examination and regional myocardial blood flow （RMBF） measurement were performed. EPCs were traced by fluorescence in situ hybridization （FISH）. The protein and mRNA expression of b-FGF in each group was measured by ELISA assay and reverse transcription-polymerase chain reaction （ RT-PCR ） . Results Three months after transplantation, sry positive cells were detected only in EPCs group. The cardiac function as well as RMBF was significantly improved in EPCs group compared with b-FGF group or control group. There was higher capillary density in EPCs group. The protein and mRNA expression of b-FGF was stronger than b-FGF group and control group. Conclusion Transplantation of EPCs can improve cardiac function, induce neovascularization and increase RMBF for DCM rats. The treatment with EPCs has better effect than administration of b-FGF alone.展开更多
Malignant ventricular arrhythmias are a major adverse event and worsen the prognosis of patients affected by ischemic and non-ischemic dilated cardiomyopathy.The main parameter currently used to stratify arrhythmic ri...Malignant ventricular arrhythmias are a major adverse event and worsen the prognosis of patients affected by ischemic and non-ischemic dilated cardiomyopathy.The main parameter currently used to stratify arrhythmic risk and guide decision making towards the implantation of a cardioverter defibrillator is the evaluation of the left ventricular ejection fraction.However,this strategy is characterized by several limitations and consequently additional parameters have been suggested in order to improve arrhythmic risk stratification.The aim of this review is to critically revise the prognostic significance of non-invasive diagnostic tools in order to better stratify the arrhythmic risk prognosis of dilated cardiomyopathy patients.展开更多
The displacement and the stress states cased by single inclusion are achieved from the fundamental solutions such as nuclei of strain in bimaterals. The elastic field induced by multiple inclusions in dissimilar media...The displacement and the stress states cased by single inclusion are achieved from the fundamental solutions such as nuclei of strain in bimaterals. The elastic field induced by multiple inclusions in dissimilar media could be found from the superstition of that of individual precipitate. In this paper, the effect of the planner interface with parameters of depth from the interface, both pairs of elastic moduli and also shapes of the inclusion are also given, which are of great significance in physical applications.展开更多
OBJECTIVE:To investigate the effects of Shenqi Yangxin decoction(SQYXD)on heart function in a rat model of dilated cardiomyopathy(DCM)and its potential mechanisms.METHODS:Sprague-Dawley rats were randomly divided into...OBJECTIVE:To investigate the effects of Shenqi Yangxin decoction(SQYXD)on heart function in a rat model of dilated cardiomyopathy(DCM)and its potential mechanisms.METHODS:Sprague-Dawley rats were randomly divided into normal(10 rats)and DCM(150 rats)groups.DCM was induced by an intraperitoneal injection of adriamycin.Then,DCM baseline group was randomly selected sixteen DCM rats.The remaining DCM rats were randomly divided into DCM control,perindopril,metoprolol,and SQYXD groups.Cardiac function and histological analysis plus biochemical measurement of serum levels of brain natriuretic peptide(BNP),and inflammatory factors were measured.The mRNA and protein expression levels of high-mobility group box 1(HMGB1),Toll-like receptor 4(TLR-4),receptor for advanced glycation end products(RAGE),and nuclear factor-κB(NF-κB)were determined.Myocardial metabolism imaging was performed on the normal,SQYXD and DCM control groups to evaluate the effectiveness of treatments.RESULTS:Rats in the DCM control group exhibited dilated left ventricular diameter,impaired cardiac function,disorganized sarcomere,impaired glucose metabolism,increased heart weight index,and increased levels of BNP,which were improved by treatment with SQYXD.In addition,hearts from rats in the DCM baseline group exhibited significantly higher levels of HMGB1,TLR-4,RAGE,NF-κB,tumor necrosis factor-α,interleukin-1,interleukin-6,interleukin-10,compared with the normal group.Interestingly,the mRNA level of HMGB1 in the DCM baseline group was positively correlated with that of TLR-4,RAGE,NF-κB,BNP,and LVEDD,but negatively correlated with LVEF.SQYXD inhibited the upregulation of HMGB1 expression and its downstream inflammatory factors.CONCLUSION:Shenqi Yangxin decoction effectively reduced the dilated left ventricular diameter and improved heart function in dilated cardiomyopathy.The mechanisms underlying the action on DCM involve regulating the gene and protein expression of HMGB1 and its inflammatory signal pathways in the DCM rat model.展开更多
With the successful application and breakthrough of deep learning technology in image segmentation,there has been continuous development in the field of seismic facies interpretation using convolutional neural network...With the successful application and breakthrough of deep learning technology in image segmentation,there has been continuous development in the field of seismic facies interpretation using convolutional neural networks.These intelligent and automated methods significantly reduce manual labor,particularly in the laborious task of manually labeling seismic facies.However,the extensive demand for training data imposes limitations on their wider application.To overcome this challenge,we adopt the UNet architecture as the foundational network structure for seismic facies classification,which has demonstrated effective segmentation results even with small-sample training data.Additionally,we integrate spatial pyramid pooling and dilated convolution modules into the network architecture to enhance the perception of spatial information across a broader range.The seismic facies classification test on the public data from the F3 block verifies the superior performance of our proposed improved network structure in delineating seismic facies boundaries.Comparative analysis against the traditional UNet model reveals that our method achieves more accurate predictive classification results,as evidenced by various evaluation metrics for image segmentation.Obviously,the classification accuracy reaches an impressive 96%.Furthermore,the results of seismic facies classification in the seismic slice dimension provide further confirmation of the superior performance of our proposed method,which accurately defines the range of different seismic facies.This approach holds significant potential for analyzing geological patterns and extracting valuable depositional information.展开更多
Objective:Qiliqiangxin(QLQX)capsule,a traditional Chinese medicine used for treating heart failure(HF),can modulate inflammatory cytokines in rats with myocardial infarction.However,its immune-regulating effect on dil...Objective:Qiliqiangxin(QLQX)capsule,a traditional Chinese medicine used for treating heart failure(HF),can modulate inflammatory cytokines in rats with myocardial infarction.However,its immune-regulating effect on dilated cardiomyopathy(DCM)remains unknown.The aim of this study was to investigate whether QLQX has a unique regulatory role in the imbalance of pro-and anti-inflammatory cytokines in patients with DCM.Methods:The QLQX-DCM is a randomized,double-blind trial conducted at 24 tertiary hospitals in China.A total of 345 patients with newly diagnosed virus-induced DCM were randomly assigned to receive QLQX capsules or placebo while receiving optimal medical therapy for HF.The primary endpoints were changes in plasma inflammatory cytokines and improvements in left ventricular ejection fraction(LVEF)and left ventricular end-diastolic diameter(LVEDd)over the 12-month treatment.Results:At the 12-month follow-up,the levels of IFN-γ,IL-17,TNF-ɑ,and IL-4 decreased significantly,while the level of IL-10 increased in both groups compared with baselines(all P<0.0001).Furthermore,these changes,coupled with improvements in LVEF,NT-proBNP and New York Heart Association(NYHA)functional classification,excluding the LVEDd in the QLQX group,were greater than those in the placebo group(all P<0.001).Additionally,compared with placebo,QLQX treatment also reduced all-cause mortality and rehospitalization rates by 2.17%and 2.28%,respectively,but the difference was not statistically significant.Conclusion:QLQX has the potential to alleviate the imbalance of inflammatory cytokines in patients with DCM,potentially leading to further improvements in cardiac function when combined with anti-HF standard medications.展开更多
Poly-scale refinable function with dilation factor a is introduced. The existence of solution of poly-scale refinable equation is investigated. Specially, necessary and sufficient conditions for the orthonormality of ...Poly-scale refinable function with dilation factor a is introduced. The existence of solution of poly-scale refinable equation is investigated. Specially, necessary and sufficient conditions for the orthonormality of solution function Ф of poly-scale refinable equation with integer dilation factor a are established. Some properties of poly-scale refinable function are discussed. Several examples illustrating how to use the method to construct poly-scale refinable function are given.展开更多
The Beurling-Ahlfors’ extension is studied under relatively general conditions and its dilatation fonction is estimated. Particularly, the classic Deurling -Ahlfors’ theorem can be obtained under the M-condition.
基金supported by the Natural Sciences and Engineering Research Council of Canada(NSERC)Discovery Grant,held by Dr.Bain(RGPIN-2020-05760).
文摘Notch1 is a mechanosensitive endothelial receptor that responds to vascular wall shear stress.However,data on Notch1 activity in humans remains limited,particularly regarding its role in endothelial function.Objectives:Accordingly,the purpose of this study was to determine whether Notch1 is associated with the flow-mediated dilatory(FMD)response and whether it is related to aerobic fitness.A secondary purpose was to determine whether Notch1 is related to concentrations of vascular endothelial growth factor(VEGF).Methods:Sixteen(8M/8F)young(20-30 yrs old)and healthy(BMI:25±4.2 kg/m^(2),blood pressure:117±11.63/69±11.25 mmHg)adults participated in the study.Aerobic fitness was determined by cycle VO_(2) peak.An FMDwas performed on the brachial artery,and blood samples were taken from an antecubital vein at rest(baseline)and 1min after cuff deflation(to align with peak vessel dilation).Concentrations of Notch1 extracellular domain(NECD)and VEGFwere determined from plasma using enzyme-linked immunosorbent assays.Results:In contrast to our hypothesis,concentrations of NECD and VEGF did not change throughout the FMDandwere unrelated to allometrically scaled FMD values(p all>0.05).Likewise,there was no relationship between changes inNECD and VEGF(p=0.331,r=0.127).However,the change in NECD across the FMD was moderately(r=0.515)and significantly(p=0.024)correlated with VO_(2) peak.Conclusions:These novel data indicate that in healthy young adults,Notch1 activity is linked to aerobic fitness but may not be acutely involved in the shear-mediated vasodilatory response.
基金supported by the Guangzhou Science and Technology Project (Industrial, Academic and Research Collaborative Innovation Project):201803010093the major development projects of sun yat-sen university: 201812281965
文摘Objective: To report outcomes of balloon dilation Eustachian tuboplasty combined with tympanostomy tube insertion and middle ear pressure equalization therapy in treatment of recurrent secretory otitis media. Methods: Fifty one patients with recurrent secretory otitis media (62 ears) underwent balloon dilation of Eustachian tube and tympanic tube insertion under general anesthesia, followed by long term middle ear pressure equalization therapies. The Eustachian tube score (ETS) and Eustachian tube function questionnaire (ETDQ-7) were used for pre- and postoperative (up to 12 months) evaluation of Eustachian tube functions. Results: The mean ETS score was 2.34 ± 0.97 preoperatively, and 6.17 ± 1.54, 7.23 ± 1.62, 8.24 ± 1.97, and 7.63 ± 1.86 at 1, 3, 6 and 12 months postoperatively, respectively (P < 0.05). The ETDQ-7 score was 4.82 ± 1.07 preoperatively, and 2.20 ± 0.54, 2.32 ± 0.68, 2.53 ± 0.79, and 2.67 ± 0.76 at 1, 3, 6 and 12 months postoperatively, respectively (P < 0.05). Conclusion: Balloon dilation of Eustachian tube combined with tympanostomy and catheterization resulted in significant improvement of subjective symptoms and objective evaluation of Eustachian tube functions in most patients with recurrent secretory otitis media, as indicated by the ETS and ETDQ-7 scores, demonstrating high levels of efficacy and patient satisfaction.
基金Project supported by the National Natural Science Foundation of China(Nos.51478435,11402150,and 11172268)
文摘Green＇s functions for Blot＇s dynamic equation in the frequency domain can be a highly useful tool for the investigation of dynamic responses of a saturated porous medium. Its applications are found in soil dynamics, seismology, earthquake engineering, rock mechanics, geophysics, and acoustics. However, the mathematical work for deriving it can be daunting. Green＇s functions have been presented utilizing an analogy between the dynamic thermoelasticity and the dynamic poroelasticity in the frequency domain using the u-p formulation. In this work, a special term ＂decoupling coefficient＂ for the decomposition of the fast and slow dilatational waves is proposed and expressed to present a new methodology for deriving the poroelastodynamic Green＇s functions. The correct- ness of the solution is demonstrated by numerically comparing the current solution with Cheng＇s previous solution. The separation of the two waves in the present methodology allows the more accurate evaluation of Green＇s functions, particularly the solution of the slow dilatational wave. This can be advantageous for the numerical implementation of the boundary element method （BEM） and other applications.
文摘Objective Dilated cardiomyopathy(DCM) is generally considered to be accompanied by both left and right ventricular dysfunction,but most studies only analyze the left ventricular function. In this study,we evaluated the effect of arotinolol on right ventricular function in patients with DCM. Methods Right ventricular ejection fraction(RVEF) and right ventricular diameter(RVD) were measured by two-dimensional echocardiography(2-DE) in 33 DCM patients;RVEF measured by first-pass radionuclide angiography(FPRA) was compared with that by 2-DE. Results The treatment with arotinolol for one year resulted in a reduction in the right ventricular diameter(baseline,23.0 ± 8.3 mm vs after one-year treatment,20.7 ± 5.4 mm;P=0.004 ) and an associated increase in ejection fraction(baseline,36.9 ± 10.3% vs after one-year treatment,45.8 ± 9.6%;P < 0.001 ) ;there is a high correlation between the 2-DE method and radionuclide ventriculographic method. The correlation coefficient is 0.933(P<0.001) . Conclusion Arotinolol therapy could not only improve left ventricular function,but also improve right ventricular function in DCM patients.
文摘Objective To evaluate the efficacy and safety of long-term treatment with arotinolol in patients with idiopathic dilated cardiomyopathy(IDCM).Methods Sixty-three patients with IDCM were evaluated at baseline and after 12-month therapy with arotinolol.The conventional therapy for congestive heart failure was continued throughout the study with arotinolol as the only β-blocker.Left ventricular function was assessed with the New York Heart Association functional class and two-dimensional echocardiography.Results After 12-month arotinolol treatment,there was a significant improvement in left ventricular systolic function.Left ventricular end-systolic dimension significantly decreased from 59.52±8.83 mm to 50.89±8.17 mm(P<0.001).Left ventricular ejection fraction significantly increased from 27.39%±7.94% to 41.13%±9.45%(P<0.001).Left ventricular mass index decreased from 150.47±42.42 g/m2 to 141.58±34.36 g/m2(P<0.01).No adverse events leading to premature discontinuation of study drug occurred.Conclusion In this preliminary study,12-month arotinolol treatment has a favorable effect on left ventricular function in patients with IDCM,and it is safe and well tolerated.
文摘Objective: Dysphagia is a frequent symptom caused by cerebral infarction. This study investigated the effect evaluation and safety of electroacupuncture combined with balloon dilatation on dysphagia after cerebral infarction. Methods: Totally 100 patients with dysphagia after cerebral infarction were enrolled as study subjects and assigned into the control group (treated with balloon dilatation) and the observation group (treated with electroacupuncture and balloon dilatation), with 50 cases in each group. The general data of participants were recorded. Before or after treatment, swallowing function was assessed by water swallow test, standardized swallowing function assessment (SSA), videofluoroscopic swallow study (VFSS), and functional oral intake scale (FOIS). The cerebral hemodynamics, serological indicators, neurological impairment, quality of life (QOL) score were analyzed. Additionally, the occurrence of complications and adverse reactions after treatment was assessed. Results: There was no significant difference in gender, age, BMI, course of disease, and grade of dysphagia between the two groups. Balloon dilatation alone and electroacupuncture combined with balloon dilatation decreased the water swallow test, SSA, and VFSS scores, increased FOIS score, and improved the swallowing function, cerebral hemodynamic parameters, serological indicators, neurological function and QOL, with the better efficacy in the combined therapy. Moreover, combined therapy had lower incidences of complications and adverse reactions than balloon dilatation therapy alone. Conclusion: Electroacupuncture intervention combined with balloon dilatation therapy ameliorates swallowing function, cerebral hemodynamics, serological indicators, neurological function and QOL, and reduces complications and adverse reactions in dysphagia after cerebral infarction.
文摘To assess the left ventricle regional systolic and diastolic function, left ventricle geometry and left venticle sphericity indexes in patients with dilated cardiomyopathy （DCM） by quantitative tissue velocity imaging （QTVI）. Methods Thirty normal subjects and 52 DCM patients underwent QTVI and colour Doppler flow imaging study in order to measure the left ventricular regional function along left ventricle apical long-axis view and the left ventricle geometry. Peak tissue velocities of left venticle regional muscular tissue during systole （ Vs）, systolic acceleration （ a）, early diastole（Ve） and left atrium contraction（Va） along left venticle apical long axis view were measured. The indexes of left ventricular regional systolic and diastolic function were mearsured at the same time. The left ventricle geometry shape was reflected from the systolic and diastolic sphericity index （Sis and Sid）, the left ventricular ejection fraction （LVEF） and D wave / A wave （PVd/PVa） of pulmonary veins flowing spectrum reflected the global left ventricular systolic and diastolic function. The Vs, Ve, Va, a, PVd/PVa ratio, LVEF, Sis, Sid and their correlations between normal subjects and patients with DCM were compared and analyzed. Results Vs, Ve, Va, a, PVd/PVa, Sis and Sid in patients with DCM were lower than those in normal persons. There were significant relations between Sis and a （ r = 0. 6142, P 〈 0. 05）, Ve/Va and Sid （ r = 0. 6271, P 〈 0. 05 ）. Conclusions QTVI offer a newer method which has a higher sensitivity and accuracy in evaluating the left venticle regional systolic and diastolic function in DCM patients. There was significant relation between regional cardiac function and left venticle sphericity. （ S Chin J Cardiol 2009; 10（1） ： 9 -14）
文摘Background: The aim of this study was to determine the relation of left atrial (LA) volume and LA volume index with left ventricular function and to determine the association of duration of symptoms and left atrial volume index in patients with dilated cardiomyopathy. Materials and Methods: This was an observational, single centre study conducted in India. A total of 50 patients who were admitted to department of cardiology from July, 2008 to February, 2009 with diagnosis of dilated cardiomyopathy and an ejection fraction of <40% were included. Results: Of the 50 patients, 34 (68%) were males. 27 (54%) patients were in NYHA class II and 23 (46%) patients were in NYHA class III. LA volume was found to be ≥40 ml in all patients. LV function and LA volume were found to be correlated (r = -0.789, p < 0.01). Similarly, there was a correlation between LV function and LA volume index (r = -0.826, p < 0.01). There was no correlation between LA volume index and duration of symptoms (r = 0.04). Conclusion: It can be concluded that there is a strong inverse correlation between LA volume and left ventricular function and also between LA volume index and left ventricular function. The patients with NYHA class III were having larger left atrial volume than those with NYHA class II. Moreover, the duration of symptoms has no correlation with left atrial volume index.
文摘Stress-dilatancy relationship or plastic potential function are crucial components of every elastoplastic constitutive model developed for sand or cemented sand.This is because the associated flow rule usually does not produce acceptable outcomes for sand or cemented sand.Many formulas have been introduced based on the experimental observations in conventional and advanced plasticity models in order to capture ratio of plastic volumetric strain increment to plastic deviatoric strain increment(i.e.dilatancy rate).Lack of an article that gathers these formulas is clear in the literature.Thus,this paper is an attempt to summarize plastic potentials and specially stress-dilatancy relations so far proposed for constitutive modelling of cohesionless and cemented sands.Stress-dilatancy relation is usually not the same under compression and extension conditions.Furthermore,it may also be different under loading and unloading conditions.Therefore,the focus in this paper mainly places on the proposed stress-dilatancy relations for compressive monotonic loading.Moreover because plastic potential function can be calculated by integration of stress-dilatancy relationship,more weight is allocated to stress-dilatancy relationship in this research.
基金Supported by the National Natural Science Foundation of China(10271077)Supported by the Educational Department of Zhejiang Province Natural Science Project(20030768)
文摘In this paper, we prove that the control function of the dilatation function of Beurling-Ahlfors extension is convex. Using the quasi-symmetric function ρ, we get a relatively sharp estimate of the dilatation function: D(x,y)≤ 17/32 (ρ(x, y) + 1) (ρ(x + y/2, y/2) +ρ(x - y/2, y/2) +2) , which improves the results before. We also show that the above result is asymptotically precise.
文摘Cardiovascular magnetic resonance (CMR) has become a reference standard for the measure-ment of cardiac volumes, function, and mass. This study aims to reconstruct three dimen-sional modeling of the left ventricle (LV) in pa-tients with heart failure (HF) using CMRtools and thereby derive the LV functional indices. CMR images were acquired in 41 subjects (6 females) with heart failure (HF) and 12 normal controls (4 females). Five comparisons were made (i) nor-mal and dilated heart failure subjects, (ii) male and female normal heart, (iii) male and female dilated heart, (iv) male normal and dilated heart failure and (v) female normal and dilated heart failure. In HF, a significant higher values of EDV (320 刡 79 vs. 126 刡 22 ml, P&amp;amp;amp;amp;lt;0.0001), ESV (255 刡 68 vs. 54 刡 12 ml, P&amp;amp;amp;amp;lt;0.00001) and lower values of EF (20 刡 7 vs. 58 刡 5 %) were found compared that of normal control. There were significant difference on LV EDV and ESV between sex in both normal and HF subjects.
文摘Objective:To investigate the effect of metoprolol on cardiac function and prognosis in patients with dilated cardiomyopathy.Methods:100 patients with dilated cardiomyopathy treated in our hospital from January 2018 to December 2019 were randomly divided into control group(n=50)and observation group(n=50).The control group was treated with conventional methods,and the observation group was treated with conventional methods and metoprolol for 6 months.The cardiac function[left ventricular ejection fraction(LVEF),stroke volume(SV),cardiac output(CO)]and prognosis[Glasgow Outcome Scale(GOS)score]of the two groups before and at the end of 6 months of intervention were compared,and the incidence of adverse reactions of the two groups were compared.Results:After 6 months of treatment,the levels of LVEF,SV and CO in the two groups were higher than before treatment,and the comparison level between the observation group and the control group was higher,the difference was statistically significant(P<0.05);After 6 months of treatment,the GOS score of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05);There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Metoprolol can improve the cardiac function and prognosis of patients with dilated cardiomyopathy,without increasing the incidence of adverse reactions.
文摘Objective To compare the different effects of endothelia progenitor cells （ EPCs ） or basic fibroblast growth factor （b-FGF） intromyocardial infusion on cardiac function and neovascularization for dilated cardiomyopathy（ DCM） rats. Methods Fifty adult female rats received inguinal subcutaneous injections of isoproterenol （ISO, 250 mg/kg） for induction of DCM. Four weeks later, the model rats were randomly divided into EPCs group, b-FGF group and control group. The 2×106 EPCs （ resolved in 100 μL PBS） , 100 μL b-FGF （ lO0 μg/mL ） and 100 μL PBS were evenly transplanted into the myocardium of EPCs group, b-FGF group and control group, respectively. Three months later, echocardiographic examination and regional myocardial blood flow （RMBF） measurement were performed. EPCs were traced by fluorescence in situ hybridization （FISH）. The protein and mRNA expression of b-FGF in each group was measured by ELISA assay and reverse transcription-polymerase chain reaction （ RT-PCR ） . Results Three months after transplantation, sry positive cells were detected only in EPCs group. The cardiac function as well as RMBF was significantly improved in EPCs group compared with b-FGF group or control group. There was higher capillary density in EPCs group. The protein and mRNA expression of b-FGF was stronger than b-FGF group and control group. Conclusion Transplantation of EPCs can improve cardiac function, induce neovascularization and increase RMBF for DCM rats. The treatment with EPCs has better effect than administration of b-FGF alone.
文摘Malignant ventricular arrhythmias are a major adverse event and worsen the prognosis of patients affected by ischemic and non-ischemic dilated cardiomyopathy.The main parameter currently used to stratify arrhythmic risk and guide decision making towards the implantation of a cardioverter defibrillator is the evaluation of the left ventricular ejection fraction.However,this strategy is characterized by several limitations and consequently additional parameters have been suggested in order to improve arrhythmic risk stratification.The aim of this review is to critically revise the prognostic significance of non-invasive diagnostic tools in order to better stratify the arrhythmic risk prognosis of dilated cardiomyopathy patients.
文摘The displacement and the stress states cased by single inclusion are achieved from the fundamental solutions such as nuclei of strain in bimaterals. The elastic field induced by multiple inclusions in dissimilar media could be found from the superstition of that of individual precipitate. In this paper, the effect of the planner interface with parameters of depth from the interface, both pairs of elastic moduli and also shapes of the inclusion are also given, which are of great significance in physical applications.
基金Supported by the Projects of Medical Technology of Management Center of Wuxi Hospital,Jiangsu Province(No.YGZXM14047:Application of Standardized Diagnosis and Treatment Scheme for Dilated Cardiomyopathy Combined with Staging)the Projects of Jiangsu Province Chinese Medicine Leading Personnel Training Target Fund(Treatment of Dilated Cardiomyopathy with Classic Compound)
文摘OBJECTIVE:To investigate the effects of Shenqi Yangxin decoction(SQYXD)on heart function in a rat model of dilated cardiomyopathy(DCM)and its potential mechanisms.METHODS:Sprague-Dawley rats were randomly divided into normal(10 rats)and DCM(150 rats)groups.DCM was induced by an intraperitoneal injection of adriamycin.Then,DCM baseline group was randomly selected sixteen DCM rats.The remaining DCM rats were randomly divided into DCM control,perindopril,metoprolol,and SQYXD groups.Cardiac function and histological analysis plus biochemical measurement of serum levels of brain natriuretic peptide(BNP),and inflammatory factors were measured.The mRNA and protein expression levels of high-mobility group box 1(HMGB1),Toll-like receptor 4(TLR-4),receptor for advanced glycation end products(RAGE),and nuclear factor-κB(NF-κB)were determined.Myocardial metabolism imaging was performed on the normal,SQYXD and DCM control groups to evaluate the effectiveness of treatments.RESULTS:Rats in the DCM control group exhibited dilated left ventricular diameter,impaired cardiac function,disorganized sarcomere,impaired glucose metabolism,increased heart weight index,and increased levels of BNP,which were improved by treatment with SQYXD.In addition,hearts from rats in the DCM baseline group exhibited significantly higher levels of HMGB1,TLR-4,RAGE,NF-κB,tumor necrosis factor-α,interleukin-1,interleukin-6,interleukin-10,compared with the normal group.Interestingly,the mRNA level of HMGB1 in the DCM baseline group was positively correlated with that of TLR-4,RAGE,NF-κB,BNP,and LVEDD,but negatively correlated with LVEF.SQYXD inhibited the upregulation of HMGB1 expression and its downstream inflammatory factors.CONCLUSION:Shenqi Yangxin decoction effectively reduced the dilated left ventricular diameter and improved heart function in dilated cardiomyopathy.The mechanisms underlying the action on DCM involve regulating the gene and protein expression of HMGB1 and its inflammatory signal pathways in the DCM rat model.
基金funded by the Fundamental Research Project of CNPC Geophysical Key Lab(2022DQ0604-4)the Strategic Cooperation Technology Projects of China National Petroleum Corporation and China University of Petroleum-Beijing(ZLZX 202003)。
文摘With the successful application and breakthrough of deep learning technology in image segmentation,there has been continuous development in the field of seismic facies interpretation using convolutional neural networks.These intelligent and automated methods significantly reduce manual labor,particularly in the laborious task of manually labeling seismic facies.However,the extensive demand for training data imposes limitations on their wider application.To overcome this challenge,we adopt the UNet architecture as the foundational network structure for seismic facies classification,which has demonstrated effective segmentation results even with small-sample training data.Additionally,we integrate spatial pyramid pooling and dilated convolution modules into the network architecture to enhance the perception of spatial information across a broader range.The seismic facies classification test on the public data from the F3 block verifies the superior performance of our proposed improved network structure in delineating seismic facies boundaries.Comparative analysis against the traditional UNet model reveals that our method achieves more accurate predictive classification results,as evidenced by various evaluation metrics for image segmentation.Obviously,the classification accuracy reaches an impressive 96%.Furthermore,the results of seismic facies classification in the seismic slice dimension provide further confirmation of the superior performance of our proposed method,which accurately defines the range of different seismic facies.This approach holds significant potential for analyzing geological patterns and extracting valuable depositional information.
基金supported by the Key Project of the National Twelfth Five-Year Research Program of China(No.2011BAI11B00,No.2011BAI11B23).
文摘Objective:Qiliqiangxin(QLQX)capsule,a traditional Chinese medicine used for treating heart failure(HF),can modulate inflammatory cytokines in rats with myocardial infarction.However,its immune-regulating effect on dilated cardiomyopathy(DCM)remains unknown.The aim of this study was to investigate whether QLQX has a unique regulatory role in the imbalance of pro-and anti-inflammatory cytokines in patients with DCM.Methods:The QLQX-DCM is a randomized,double-blind trial conducted at 24 tertiary hospitals in China.A total of 345 patients with newly diagnosed virus-induced DCM were randomly assigned to receive QLQX capsules or placebo while receiving optimal medical therapy for HF.The primary endpoints were changes in plasma inflammatory cytokines and improvements in left ventricular ejection fraction(LVEF)and left ventricular end-diastolic diameter(LVEDd)over the 12-month treatment.Results:At the 12-month follow-up,the levels of IFN-γ,IL-17,TNF-ɑ,and IL-4 decreased significantly,while the level of IL-10 increased in both groups compared with baselines(all P<0.0001).Furthermore,these changes,coupled with improvements in LVEF,NT-proBNP and New York Heart Association(NYHA)functional classification,excluding the LVEDd in the QLQX group,were greater than those in the placebo group(all P<0.001).Additionally,compared with placebo,QLQX treatment also reduced all-cause mortality and rehospitalization rates by 2.17%and 2.28%,respectively,but the difference was not statistically significant.Conclusion:QLQX has the potential to alleviate the imbalance of inflammatory cytokines in patients with DCM,potentially leading to further improvements in cardiac function when combined with anti-HF standard medications.
基金Project supported by the Natural Science Foundation of Guangdong Province (Nos.032038, 05008289, 06105648) the Doctoral Foundation of Guangdong Province (No.04300917)
文摘Poly-scale refinable function with dilation factor a is introduced. The existence of solution of poly-scale refinable equation is investigated. Specially, necessary and sufficient conditions for the orthonormality of solution function Ф of poly-scale refinable equation with integer dilation factor a are established. Some properties of poly-scale refinable function are discussed. Several examples illustrating how to use the method to construct poly-scale refinable function are given.
文摘The Beurling-Ahlfors’ extension is studied under relatively general conditions and its dilatation fonction is estimated. Particularly, the classic Deurling -Ahlfors’ theorem can be obtained under the M-condition.
