This paper presents a component object model(COM)based framework for managing,analyzing and visualizing massive multi-scale digital elevation models(DEMs).The framework consists of a data management component(DMC),whi...This paper presents a component object model(COM)based framework for managing,analyzing and visualizing massive multi-scale digital elevation models(DEMs).The framework consists of a data management component(DMC),which is based on RDBMS/ORDBMS,a data analysis component(DAC)and a data render component(DRC).DMC can manage massive multi-scale data expressed at various reference frames within a pyramid database and can support fast access to data at variable resolution.DAC integrates many useful applied analytic functions whose results can be overlaid with the 3D scene rendered by DRC.DRC provides view-dependent data paging with the support of the underlying DMC and organizes the potential visible data at different levels into rendering.展开更多
Optic neuropathies lead to blindness;the common pathology is the degeneration of axons of the retinal ganglion cells. In this study, we used a rat model of retinal ischemia-reperfusion and a one-time intravitreal brai...Optic neuropathies lead to blindness;the common pathology is the degeneration of axons of the retinal ganglion cells. In this study, we used a rat model of retinal ischemia-reperfusion and a one-time intravitreal brain-derived neurotrophic factor(BDNF)injection;then we examined axon transportation function, continuity, physical presence of axons in different part of the optic nerve, and the expression level of proteins involved in axon transportation. We found that in the disease model, axon transportation was the most severely affected, followed by axon continuity, then the number of axons in the distal and proximal optic nerve. BDNF treatment relieved all reductions and significantly restored function. The molecular changes were more minor,probably due to massive gliosis of the optic nerve, so interpretation of protein expression data should be done with some caution.The process in this acute model resembles a fast-forward of changes in the chronic model of glaucoma. Therefore, impairment in axon transportation appears to be a common early process underlying different optic neuropathies. This research on effective intervention can be used to develop interventions for all optic neuropathies targeting axon transportation.展开更多
文摘This paper presents a component object model(COM)based framework for managing,analyzing and visualizing massive multi-scale digital elevation models(DEMs).The framework consists of a data management component(DMC),which is based on RDBMS/ORDBMS,a data analysis component(DAC)and a data render component(DRC).DMC can manage massive multi-scale data expressed at various reference frames within a pyramid database and can support fast access to data at variable resolution.DAC integrates many useful applied analytic functions whose results can be overlaid with the 3D scene rendered by DRC.DRC provides view-dependent data paging with the support of the underlying DMC and organizes the potential visible data at different levels into rendering.
基金supported by The Key Project of National Natural Science Foundation of China(31030036)to Shanghai。
文摘Optic neuropathies lead to blindness;the common pathology is the degeneration of axons of the retinal ganglion cells. In this study, we used a rat model of retinal ischemia-reperfusion and a one-time intravitreal brain-derived neurotrophic factor(BDNF)injection;then we examined axon transportation function, continuity, physical presence of axons in different part of the optic nerve, and the expression level of proteins involved in axon transportation. We found that in the disease model, axon transportation was the most severely affected, followed by axon continuity, then the number of axons in the distal and proximal optic nerve. BDNF treatment relieved all reductions and significantly restored function. The molecular changes were more minor,probably due to massive gliosis of the optic nerve, so interpretation of protein expression data should be done with some caution.The process in this acute model resembles a fast-forward of changes in the chronic model of glaucoma. Therefore, impairment in axon transportation appears to be a common early process underlying different optic neuropathies. This research on effective intervention can be used to develop interventions for all optic neuropathies targeting axon transportation.
