In this paper, investigation has been done in the computer simulation of the electrostatic coupling IBC by using the developed finite-element models, in which a.the incidence and reflection of electronic signal in the...In this paper, investigation has been done in the computer simulation of the electrostatic coupling IBC by using the developed finite-element models, in which a.the incidence and reflection of electronic signal in the upper arm model were analyzed by using the theory of electromagnetic wave;b.the finite-element models of electrostatic coupling IBC were developed by using the electromagnetic analysis package of ANSYS software;c.the signal attenuation of electrostatic coupling IBC were simulated under the conditions of different signal frequencies, electrodes directions, electrodes sizes and transmission distances. Finally, some important conclusions are deduced on the basis of simulation results.展开更多
Propagation of coupled electrostatic drift and ion-acoustic waves（DIAWs） is presented. It is shown that nonlinear solitary vortical structures can be formed by low-frequency coupled electrostatic DIAWs. Primary wave...Propagation of coupled electrostatic drift and ion-acoustic waves（DIAWs） is presented. It is shown that nonlinear solitary vortical structures can be formed by low-frequency coupled electrostatic DIAWs. Primary waves of distinct（small, intermediate and large） scales are considered. Appropriate set of 3 D equations consisting of the generalized Hasegawa-Mima equation for the electrostatic potential（involving both vector and scalar nonlinearities） and the equation of motion of ions parallel to magnetic field are obtained. According to experiments of laboratory plasma mainly focused to large scale DIAWs, the possibility of self-organization of DIAWs into the nonlinear solitary vortical structures is shown analytically. Peculiarities of scalar nonlinearities in the formation of solitary vortical structures are widely discussed.展开更多
Astaxanthin(AXT)with mitochondria-targeted ability is desired for effectively preventing oxidative stress in various intestinal diseases.However,it is challenging to prepare mitochondria-targeted AXT(Mito-AXT)using tr...Astaxanthin(AXT)with mitochondria-targeted ability is desired for effectively preventing oxidative stress in various intestinal diseases.However,it is challenging to prepare mitochondria-targeted AXT(Mito-AXT)using traditional covalent bond methods due to the fragile structure of AXT and harsh reaction conditions,which result in low production yields and poor biocompatibility.Herein,we proposed a strategy to enhance the mitochondriatargeted efficiency of AXT by combining it with lipophilic cationic compounds through a non-covalent approach.Mito-AXT was synthesized through electrostatic coupling between anionic sulfonate-modified AXT(AXT-SO3)and cationic(3-carboxypropyl)triphenylphosphonium bromide(TPP).The synthetic strategy successfully preserved the inherent DPPH and hydroxyl radical trapping capacity of AXT and achieved the efficient preparation of Mito-AXT with a yield of 86.17%.The accumulation of cationic TPP in mitochondria after the disassembly of Mito-AXT surprisingly facilitated the enrichment of anionic AXT-SO3 in mitochondria.Notably,Mito-AXT regulated the redox balance,mitochondrial membrane potential,and mitophagy in IEC-6 cells under oxidative stress,thereby preventing apoptosis,compared to TPP-modified AXT molecules formed by covalent bonds.Furthermore,biosecurity analysis confirmed that Mito-AXT exhibited excellent biocompatibility.The results provided a simple,effective,and safe way to enhance the mitochondria-targeted efficiency of AXT through Mito-AXT,thereby effectively regulating the mitochondrial homeostasis in intestinal cells under oxidative stress.展开更多
基金National Natural Science Foundation of China ( No. 60801050)the Basic Research Foundationof Beijing Institute of Technology of China ( No. 1010050320804) National Innovation Experiment Program for University Students( 2010)
文摘In this paper, investigation has been done in the computer simulation of the electrostatic coupling IBC by using the developed finite-element models, in which a.the incidence and reflection of electronic signal in the upper arm model were analyzed by using the theory of electromagnetic wave;b.the finite-element models of electrostatic coupling IBC were developed by using the electromagnetic analysis package of ANSYS software;c.the signal attenuation of electrostatic coupling IBC were simulated under the conditions of different signal frequencies, electrodes directions, electrodes sizes and transmission distances. Finally, some important conclusions are deduced on the basis of simulation results.
文摘Propagation of coupled electrostatic drift and ion-acoustic waves（DIAWs） is presented. It is shown that nonlinear solitary vortical structures can be formed by low-frequency coupled electrostatic DIAWs. Primary waves of distinct（small, intermediate and large） scales are considered. Appropriate set of 3 D equations consisting of the generalized Hasegawa-Mima equation for the electrostatic potential（involving both vector and scalar nonlinearities） and the equation of motion of ions parallel to magnetic field are obtained. According to experiments of laboratory plasma mainly focused to large scale DIAWs, the possibility of self-organization of DIAWs into the nonlinear solitary vortical structures is shown analytically. Peculiarities of scalar nonlinearities in the formation of solitary vortical structures are widely discussed.
基金supported by the National Natural Science Foundation of China(32430083).
文摘Astaxanthin(AXT)with mitochondria-targeted ability is desired for effectively preventing oxidative stress in various intestinal diseases.However,it is challenging to prepare mitochondria-targeted AXT(Mito-AXT)using traditional covalent bond methods due to the fragile structure of AXT and harsh reaction conditions,which result in low production yields and poor biocompatibility.Herein,we proposed a strategy to enhance the mitochondriatargeted efficiency of AXT by combining it with lipophilic cationic compounds through a non-covalent approach.Mito-AXT was synthesized through electrostatic coupling between anionic sulfonate-modified AXT(AXT-SO3)and cationic(3-carboxypropyl)triphenylphosphonium bromide(TPP).The synthetic strategy successfully preserved the inherent DPPH and hydroxyl radical trapping capacity of AXT and achieved the efficient preparation of Mito-AXT with a yield of 86.17%.The accumulation of cationic TPP in mitochondria after the disassembly of Mito-AXT surprisingly facilitated the enrichment of anionic AXT-SO3 in mitochondria.Notably,Mito-AXT regulated the redox balance,mitochondrial membrane potential,and mitophagy in IEC-6 cells under oxidative stress,thereby preventing apoptosis,compared to TPP-modified AXT molecules formed by covalent bonds.Furthermore,biosecurity analysis confirmed that Mito-AXT exhibited excellent biocompatibility.The results provided a simple,effective,and safe way to enhance the mitochondria-targeted efficiency of AXT through Mito-AXT,thereby effectively regulating the mitochondrial homeostasis in intestinal cells under oxidative stress.
