We report the simulation and experimental results of 1.3-μm InGaAsP/InP multiple quantum well （MQW） electro-absorption modulators （EAMs）. In this work, the quantum confined Stark effect of the EAM is system- atic...We report the simulation and experimental results of 1.3-μm InGaAsP/InP multiple quantum well （MQW） electro-absorption modulators （EAMs）. In this work, the quantum confined Stark effect of the EAM is system- atically analyzed through the finite element method. An optimized structure of the 1.3-μm InGaAsP/InP QW EAM is proposed for applications in 100 G ethernet. Then 1.3-μm InGaAsP/InP EAMs with f-3dB bandwidth of over 20 GHz and extinction ratio over 20 dB at 3 V bias voltage are demonstrated.展开更多
An electro-absorption(EA)modulator is one of key components for optical fiber communications due to the high speed,small size,low voltage and integration ability with other semiconductor devices.A 40 Gb/s InGaAsP/InP ...An electro-absorption(EA)modulator is one of key components for optical fiber communications due to the high speed,small size,low voltage and integration ability with other semiconductor devices.A 40 Gb/s InGaAsP/InP multiplequantum-well(MQW)EA modulator monolithically integrated with a semiconductor optical amplifier(SOA)was fabricated for digital communications.The modulator capacitance was reduced to obtain 40 GHz bandwidth,and the SOA section helped reduce the insertion loss from 18 dB to 3 dB.InGaAlAs/InP MQW EA modulators have also been fabricated and characterized for analog optical fiber communications.A low driving voltage of 2.7 V and high spurious free dynamic range of 107 dB·Hz2/3 were estimated by static and dynamic measurements.展开更多
Integrated electro-absorption-modulated distributed feedback laser diodes(EMLs)are attracting much interest in optical communications for the advantages of a compact structure,low power consumption,and high-speed modu...Integrated electro-absorption-modulated distributed feedback laser diodes(EMLs)are attracting much interest in optical communications for the advantages of a compact structure,low power consumption,and high-speed modulation.In integrated EML,the microwave interaction between the distributed feedback laser diode(DFB-LD)and the electro-absorption modulator(EAM)has a nonnegligible influence on the modulation performance,especially at the high-frequency region.In this paper,integrated EML was investigated as a three-port network with two electrical inputs and a single optical output,where the scattering matrix of the integrated device was theoretically deduced and experimentally measured.Based on the theoretical model and the measured data,the microwave equivalent circuit model of the integrated device was established,from which the microwave interaction between DFB-LD and EAM was successfully extracted.The results reveal that the microwave interaction within integrated EML contains both the electrical isolation and optical coupling.The electrical isolation is bidirectional while the optical coupling is directional,which aggravates the microwave interaction in the direction from DFB-LD to EAM.展开更多
We report a wavelength tunable electro-absorption modulated DBR laser based on a combined method of SAG and QWI. The threshold current is 37mA and the output power at 100mA gain current is 3.5mW. When coupled to a sin...We report a wavelength tunable electro-absorption modulated DBR laser based on a combined method of SAG and QWI. The threshold current is 37mA and the output power at 100mA gain current is 3.5mW. When coupled to a single-mode fiber with a coupling efficiency of 15% ,more than a 20dB extinction ratio is observed over the change of EAM bias from 0 to -2V. The 4.4nm continuous wavelength tuning range covers 6 channels on a 100GHz grid for WDM telecommunications.展开更多
Monolithic electro absorption modulated distributed feedback(DFB) lasers are proposed and fabricated by using a modified double stack active layer.The 38mA threshold,9dB extinction ratio (from 0 5V to 3 0V),and ab...Monolithic electro absorption modulated distributed feedback(DFB) lasers are proposed and fabricated by using a modified double stack active layer.The 38mA threshold,9dB extinction ratio (from 0 5V to 3 0V),and about 5mW output power at the 100mA operation current are achieved.Compared with other reported results (only 1 5mW at the same operation current) of the traditional stack active structure,the proposed structure improves the output power of devices.展开更多
An ultra-wide and flat optical frequency comb(OFC) generation scheme using multiple continuous wave(CW) light sources based on electro-absorption modulator(EAM) and frequency modulator(FM) is proposed. In the scheme, ...An ultra-wide and flat optical frequency comb(OFC) generation scheme using multiple continuous wave(CW) light sources based on electro-absorption modulator(EAM) and frequency modulator(FM) is proposed. In the scheme, each CW light source is broadened and modulated by the first EAM and FM, respectively. The second EAM is introduced to flatten the ultra-wide OFC lines. By setting the wavelength spacing of light sources equal to the bandwidth of sub-OFC, an ultra-wide OFC can be obtained. Principle analysis and simulation for the scheme are performed. The results show that in the case of a single light source, a tunable and flat OFC is obtained. With the increase of light sources, the bandwidth of the generated ultra-wide OFC expands rapidly. In the case of 28 light sources, a 22 GHz ultra-wide OFC with bandwidth of 16.52 THz can be generated.展开更多
A compact electro-absorption modulator based on graphene photonic crystal fiber is proposed. To enhance the graphene–light interaction efficiency, the innermost six air-holes of photonic crystal fiber are replaced by...A compact electro-absorption modulator based on graphene photonic crystal fiber is proposed. To enhance the graphene–light interaction efficiency, the innermost six air-holes of photonic crystal fiber are replaced by two large semicircular holes, and monolayer graphene is deposited on the two large semicircular holes. By optimizing the structure parameters, a strong graphene–light interaction is obtained. Moreover, the switch on–off point of the modulator is unchangeable,which is only related to the frequency of the incident light. The influence factors of this composite structure have been analyzed. The proposed modulator is compared with other graphene-based modulators, and the results show that it is filled without dielectric spacer. There are some excellent performances, such as an extinction ratio 7 dB of y-polarization mode,3-dB modulation bandwidth of 70 GHz with small footprint of 205 μm, and a consumption of energy per bit 59 pJ/bit.展开更多
Efficient coupling from the silicon waveguide to the GeSi layer is the key to success in the GeSi electro-absorption （EA） modulator based on evanescent coupling. A lateral taper in the upper GeSi layer has room for ...Efficient coupling from the silicon waveguide to the GeSi layer is the key to success in the GeSi electro-absorption （EA） modulator based on evanescent coupling. A lateral taper in the upper GeSi layer has room for increasing the modulating efficiency and alleviating the sensitivity of the extinction ratio （ER） and insertion loss （IL） to the length of the active region. The light behavior and the effect of the taper are explored in detail using the beam propagation method （BPM）. After optimization, the light can nearly be totally confined in the GeSi layer without any oscillation. The modulator with the designed taper can achieve low IL and high ER.展开更多
Currently,the global 5G network,cloud computing,and data center industries are experiencing rapid development.The continuous growth of data center traffic has driven the vigorous progress in high-speed optical transce...Currently,the global 5G network,cloud computing,and data center industries are experiencing rapid development.The continuous growth of data center traffic has driven the vigorous progress in high-speed optical transceivers for optical interconnection within data centers.The electro-absorption modulated laser(EML),which is widely used in optical fiber communications,data centers,and high-speed data transmission systems,represents a high-performance photoelectric conversion device.Compared to traditional directly modulated lasers(DMLs),EMLs demonstrate lower frequency chirp and higher modulation bandwidth,enabling support for higher data rates and longer transmission distances.This article introduces the composition,working principles,manufacturing processes,and applications of EMLs.It reviews the progress on advanced indium phosphide(InP)-based EML devices from research institutions worldwide,while summarizing and comparing data transmission rates and key technical approaches across various studies.展开更多
In this paper,we proposed a novel ultra・flat broadband microwave frequency comb(MFC)generation based on optical frequency comb(OFC)with a multiplequantum-well electroabsorption modulator(MQW-EAM)in critical state.The ...In this paper,we proposed a novel ultra・flat broadband microwave frequency comb(MFC)generation based on optical frequency comb(OFC)with a multiplequantum-well electroabsorption modulator(MQW-EAM)in critical state.The scheme is simple and easy to adjust.The performance of the MFC generation scheme is investigated using software Optisystem.The results show that the comb spacing of MFC can be adjusted from 5 to 20 GHz by changing RF signafs frequency and the MFC is almost independent on the linewidth of the tunable laser diode.The performance of the MFC can be improved by reasonably increasing the voltage of the RF,the smallsignal gain of the Erbium-doped fiber amplifier(EDFA)and the responsivity of the photodetector.The MFC generated by this scheme has 300 GHz effective bandwidth with 15 comb lines,whose power variation is 0.02 dB,when the components9 parameters in the Optisystem are set as follows:the power of tunable laser diode(TLD)is 0 dBm,the wavelength is 1552.52 nm,and linewidth is 1 MHz;RF signaPs frequency is 20 GHz and the voltage is 10 V;the reverse bias voltage of MQW-EAM is 6.92 V;the small-signal gain of the EDFA is 40 dB;the responsivity of the photodetector(PD)is 1 A/W.展开更多
Bone morphogenetic proteins are essential for bone regeneration/fracture healing but can also induce heterotopic ossification(HO).Understanding accessory factors modulating BMP signaling would provide both a means of ...Bone morphogenetic proteins are essential for bone regeneration/fracture healing but can also induce heterotopic ossification(HO).Understanding accessory factors modulating BMP signaling would provide both a means of enhancing BMP-dependent regeneration while preventing HO.This study focuses on the ability of the collagen receptor,discoidin domain receptor 2(DDR2),to regulate BMP activity.As will be shown,induction of bone formation by subcutaneous BMP2 implants is severely compromised in Ddr2-deficient mice.In addition,Ddr2 deficiency attenuates HO in mice expressing the ACVR1 mutation associated with human fibrodysplasia ossificans progressiva.In cells migrating into BMP2 implants,DDR2 is co-expressed with GLI1,a skeletal stem cell marker,and DDR2/GLI1-positive cells participate in BMP2-induced bone formation where they contribute to chondrogenic and osteogenic lineages.Consistent with this distribution,conditional knockout of Ddr2 in Gli1-expressing cells inhibited bone formation to the same extent seen in globally Ddr2-deficient animals.This response was explained by selective inhibition of Gli1+cell proliferation without changes in apoptosis.The basis for this DDR2 requirement was explored further using bone marrow stromal cells.Although Ddr2 deficiency inhibited BMP2-dependent chondrocyte and osteoblast differentiation and in vivo,bone formation,early BMP responses including SMAD phosphorylation remained largely intact.Instead,Ddr2 deficiency reduced the nuclear/cytoplasmic ratio of the Hippo pathway intermediates,YAP and TAZ.This suggests that DDR2 regulates Hippo pathway-mediated responses to the collagen matrix,which subsequently affect BMP responsiveness.In summary,DDR2 is an important modulator of BMP signaling and a potential therapeutic target both for enhancing regeneration and treating HO.展开更多
Spatial memory is crucial for survival within external surroundings and wild environments.The hippocampus,a critical hub for spatial learning and memory formation,has received extensive investigations on how neuromodu...Spatial memory is crucial for survival within external surroundings and wild environments.The hippocampus,a critical hub for spatial learning and memory formation,has received extensive investigations on how neuromodulators shape its functions(Teixeira et al.,2018;Zhang et al.,2024).However,the landscape of neuromodulations in the hippocampal system remains poorly understood because most studies focus on classical monoamine neuromodulators,such as acetylcholine,serotonin,dopamine,and noradrenaline.The neuropeptides,comprising the most abundant neuromodulators in the central nervous system,play a pivotal role in neural information processing in the hippocampal system.Cholecystokinin(CCK),one of the most abundant neuropeptides,has been implicated in regulating various physiological and neurobiological statuses(Chen et al.,2019).CCK-A receptor(CCK-AR)and CCK-B receptors(CCK-BR)are two key receptors mediating the biological functions of CCK,both of which belong to class-A sevenfold transmembrane G protein-coupled receptors(Nishimura et al.,2015).CCK-AR preferentially reacts to sulfated CCK,whereas CCK-BR binds both CCK and gastrin with similar affinities(Ding et al.,2022).The expression patterns of CCK-AR and CCK-BR are distinct,implying that CCK has various functions in target regions.For instance,CCK-AR is widely expressed in the GI and brain subregions and is hence implicated in the control of digestive function and satiety regulation.Conversely,CCK-BR is abundantly and widely distributed in the central nervous system,which majorly regulates anxiety,learning,and memory(Ding et al.,2022).However,the roles of endogenous CCK and CCK receptors in regulating hippocampal function at electrophysiological and behavioral levels have received less attention.展开更多
Astrocytes,the main population of glial cells in the central nervous system(CNS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental...Astrocytes,the main population of glial cells in the central nervous system(CNS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental stage to adult life.To maintain the optimal functionality of the brain,astroglial cells are particularly committed to reacting to every change in tissue homeostatic conditions,from mild modifications of the physiological environment,a process called astrocyte activation,to the more severe alterations occurring in pathological situations causing astrocyte reactivity or reactive astrogliosis(Escartin et al.,2021).During these reactive states,astrocytes mount an active,progressive response encompassing morphological,molecular,and interactional remodeling,leading to the acquisition of new functions and the loss of others,whose intensity,duration,and reversibility are dependent on the nature of the stimulus and regulated in a context-specific manner.展开更多
As the demand for computing power in data centers continues to grow, balancing data transmitting speed and energy efficiency has emerged as a critical challenge. Highbandwidth, low-power interconnection schemes are in...As the demand for computing power in data centers continues to grow, balancing data transmitting speed and energy efficiency has emerged as a critical challenge. Highbandwidth, low-power interconnection schemes are increasingly recognized as core requirements for next-generation intelligent computing center designs^([1, 2]). For short-range optical interconnections of intra-chip and inter-chip—typically covering tens of meters or less—microring resonant modulators (MRM) are emerging as an ideal solution.展开更多
Based on previous experience,learning to avoid or seek certain specific stimuli again in the future is crucial for survival.Our brains are wired to assign a particular valence-either positive or negativeas a result of...Based on previous experience,learning to avoid or seek certain specific stimuli again in the future is crucial for survival.Our brains are wired to assign a particular valence-either positive or negativeas a result of sensory stimuli,and it is this valence that serves as the foundational motivation for our subsequent actions.Simply put,all motivational actions fall into two categories:pleasure-seeking behavior guided by positive emotional valence,and pain-avoiding behavior driven by negative emotional valence[1].The ability to shift from one emotional valence to another is an important characteristic of affective states,while the instability of emotional states underlies many psychiatric disorders,highlighting the clinical importance of managing and understanding these fluctuations.This ability to adapt emotional responses can be attained by modulating the gain across distinct neural pathways,thus enabling the nuanced and smooth assignment of valence through the strengthening or weakening of circuit activity[1,2].展开更多
With the continuous improvement of signal processing accuracy requirements in modern electronic systems,the demand for high-precision analog-to-digital converters(ADCs)is increasing.Sigma-Delta modulator,as the most i...With the continuous improvement of signal processing accuracy requirements in modern electronic systems,the demand for high-precision analog-to-digital converters(ADCs)is increasing.Sigma-Delta modulator,as the most important component of high-precision ADC,is widely used in high-quality audio,high-precision instrument measurement,and other fields due to its advantages of high precision,strong noise resistance,and low hardware cost.This article designs a discrete structure third-order four-bit high-precision Sigma-Delta modulator through modeling,with an oversampling rate set to 512.Under ideal conditions,the simulation results show that the SDNR reaches 152.7db and the ENOB is 25.24bits.After introducing non-ideal noise,the system performance has decreased.The simulation results show that the SDNR is as high as 124.5db and the ENOB is 20.39bits.This indicates that the design can achieve high-precision conversion and provide assistance for further research in the future.展开更多
Femtosecond laser processing is an important machining method for micro-optical components such as Fresnel zone plate(FZP).However,the low processing efficiency of the femtosecond laser restricts its application.Here,...Femtosecond laser processing is an important machining method for micro-optical components such as Fresnel zone plate(FZP).However,the low processing efficiency of the femtosecond laser restricts its application.Here,a femtosecond laser Bessel beam is proposed to process micro-FZP,which is modulated from a Gaussian beam to a Bessel annular beam.The processing time for FZP with an outer diameter of 60μm is reduced from 30 min to 1.5 min on an important semiconductor material gallium arsenide(GaAs),which significantly improves the processing efficiency.In the modulation process,a central ablation hole that has an adverse effect on the diffraction performance is produced,and the adverse effect is eliminated by superimposing the blazed grating hologram.Meanwhile,the FZP machined by spatial light modulator(SLM)has good morphology and higher diffraction efficiency,which provides a strong guarantee for the application of micro-FZP in computed tomography and solar photovoltaic cells.展开更多
Objectives:The phytochemical investigation of traditional herbal medicines holds significant promise for modern drug discovery,particularly in cancer therapy.This study aimed to evaluate the cytotoxicity,apoptosis ind...Objectives:The phytochemical investigation of traditional herbal medicines holds significant promise for modern drug discovery,particularly in cancer therapy.This study aimed to evaluate the cytotoxicity,apoptosis induction,and immune-modulatory activities of extracts from three herbal medicines with historical use in traditional medicine—Acanthopanax sessiliflorus,Phragmites communis,and Pinus densiflora,as well as their combined extract(GMAS 01/COM),on human lung cancer cells(A549)and normal cell lines,including murine macrophages(RAW 264.7)and human keratinocytes(HaCaT).Methods:Plant extracts were prepared using aqueous extraction,sonication,and rotary evaporation.The total phenolic and flavonoid contents were quantified using the Folin-Ciocalteu and AlCl3 colorimetric methods,respectively.Antioxidant potential was evaluated via 2,2-Diphenyl-1-picrylhydrazyl(DPPH)scavenging and reducing power assays.Cytotoxicity was assessed using an MTT assay,while reactive oxygen species(ROS)generation was quantified using a 2′,7′-Dichlorodihydrofluorescein diacetate(DCFH-DA)assay.Anticancer properties,including colony formation inhibition and migration suppression,were examined using colony formation and wound healing assays.The expression of apoptotic and inflammatory mediators was analysed through qPCR.Results:GMAS 01 selectively induced apoptosis in A549 cells without cytotoxic effects on RAW264.7 and HaCaT cells.Mechanistically,it elevated intracellular ROS and activated the intrinsic mitochondrial apoptotic pathway,evidenced by p53 upregulation,increased Bax,and decreased Bcl-2 expression.GMAS 01 also significantly inhibited colony formation and migration in A549 cells.In RAW264.7 cells,it reduced nitric oxide(NO)production and downregulated iNOS,COX-2,IL-6,and IL-8,indicating strong immunomodulatory activity.Conclusion:GMAS 01 exhibits potent antioxidant,anti-inflammatory,and anticancer effects,likely mediated through ROS-induced mitochondrial apoptosis.However,mechanistic interpretations are limited by the absence of protein-level validation and pathway inhibition studies.Upcoming studies should aim to verify the underlying mechanisms and evaluate their potential for real-world application.展开更多
In this paper,we present a novel first-order digitalΣΔconverter tailored for digital-to-analog applications,focusing on achieving both high yield and reduced silicon estate.Our approach incorporates a substantial le...In this paper,we present a novel first-order digitalΣΔconverter tailored for digital-to-analog applications,focusing on achieving both high yield and reduced silicon estate.Our approach incorporates a substantial level of dithering noise into the input signal,strategically aimed at mitigating the spurious frequencies commonly encountered in such converters.Validation of our design is performed through simulations using a high-level simulator specialized in mixed-signal circuit analysis.The results underscore the enhanced performance of our circuit,especially in reducing spurious frequencies,highlighting its efficiency and effectiveness.The final circuit exhibits an effective number of bits of 13.展开更多
Lysophosphatidic acid(LPA)is a pleiotropic lipid agonist essential for functions of the central nervous system(CNS).It is abundant in the developing and adult brain while its concentration in biological fluids,includi...Lysophosphatidic acid(LPA)is a pleiotropic lipid agonist essential for functions of the central nervous system(CNS).It is abundant in the developing and adult brain while its concentration in biological fluids,including cerebrospinal fluid,varies significantly(Figure 1Α;Yung et al.,2014).LPA actually corresponds to a variety of lipid species that include different stereoisomers with either saturated or unsaturated fatty acids bearing likely differentiated biological activities(Figure 1Α;Yung et al.,2014;Hernández-Araiza et al.,2018).展开更多
基金Supported by the National Natural Science Foundation of China under Grant Nos 61274046,61474111 and 61321063the National High-Technology Research and Development Program of China under Grant No 2013AA014202
文摘We report the simulation and experimental results of 1.3-μm InGaAsP/InP multiple quantum well （MQW） electro-absorption modulators （EAMs）. In this work, the quantum confined Stark effect of the EAM is system- atically analyzed through the finite element method. An optimized structure of the 1.3-μm InGaAsP/InP QW EAM is proposed for applications in 100 G ethernet. Then 1.3-μm InGaAsP/InP EAMs with f-3dB bandwidth of over 20 GHz and extinction ratio over 20 dB at 3 V bias voltage are demonstrated.
基金supported by National ScienceFoundation Programs(60536020,60723002)"973"State Key Basic Research Programs(2006CB302800,2006CB921106)
文摘An electro-absorption(EA)modulator is one of key components for optical fiber communications due to the high speed,small size,low voltage and integration ability with other semiconductor devices.A 40 Gb/s InGaAsP/InP multiplequantum-well(MQW)EA modulator monolithically integrated with a semiconductor optical amplifier(SOA)was fabricated for digital communications.The modulator capacitance was reduced to obtain 40 GHz bandwidth,and the SOA section helped reduce the insertion loss from 18 dB to 3 dB.InGaAlAs/InP MQW EA modulators have also been fabricated and characterized for analog optical fiber communications.A low driving voltage of 2.7 V and high spurious free dynamic range of 107 dB·Hz2/3 were estimated by static and dynamic measurements.
基金This work was supported by the National Key Research and Development Program of China under Grant No.2018YFE0201900the National Natural Science Foundation of China under Grants No.61927821 and No.61875240the Joint Research Fund of Ministry of Education of China under Grant No.6141A02022436.
文摘Integrated electro-absorption-modulated distributed feedback laser diodes(EMLs)are attracting much interest in optical communications for the advantages of a compact structure,low power consumption,and high-speed modulation.In integrated EML,the microwave interaction between the distributed feedback laser diode(DFB-LD)and the electro-absorption modulator(EAM)has a nonnegligible influence on the modulation performance,especially at the high-frequency region.In this paper,integrated EML was investigated as a three-port network with two electrical inputs and a single optical output,where the scattering matrix of the integrated device was theoretically deduced and experimentally measured.Based on the theoretical model and the measured data,the microwave equivalent circuit model of the integrated device was established,from which the microwave interaction between DFB-LD and EAM was successfully extracted.The results reveal that the microwave interaction within integrated EML contains both the electrical isolation and optical coupling.The electrical isolation is bidirectional while the optical coupling is directional,which aggravates the microwave interaction in the direction from DFB-LD to EAM.
文摘We report a wavelength tunable electro-absorption modulated DBR laser based on a combined method of SAG and QWI. The threshold current is 37mA and the output power at 100mA gain current is 3.5mW. When coupled to a single-mode fiber with a coupling efficiency of 15% ,more than a 20dB extinction ratio is observed over the change of EAM bias from 0 to -2V. The 4.4nm continuous wavelength tuning range covers 6 channels on a 100GHz grid for WDM telecommunications.
文摘Monolithic electro absorption modulated distributed feedback(DFB) lasers are proposed and fabricated by using a modified double stack active layer.The 38mA threshold,9dB extinction ratio (from 0 5V to 3 0V),and about 5mW output power at the 100mA operation current are achieved.Compared with other reported results (only 1 5mW at the same operation current) of the traditional stack active structure,the proposed structure improves the output power of devices.
基金supported by the Specialized Research Fund for the National Natural Science Foundation of China(Nos.61275067 and 61302026)the Provincial Natural Foundation of Jiangsu(Nos.BK2012830 and BK2012432)
文摘An ultra-wide and flat optical frequency comb(OFC) generation scheme using multiple continuous wave(CW) light sources based on electro-absorption modulator(EAM) and frequency modulator(FM) is proposed. In the scheme, each CW light source is broadened and modulated by the first EAM and FM, respectively. The second EAM is introduced to flatten the ultra-wide OFC lines. By setting the wavelength spacing of light sources equal to the bandwidth of sub-OFC, an ultra-wide OFC can be obtained. Principle analysis and simulation for the scheme are performed. The results show that in the case of a single light source, a tunable and flat OFC is obtained. With the increase of light sources, the bandwidth of the generated ultra-wide OFC expands rapidly. In the case of 28 light sources, a 22 GHz ultra-wide OFC with bandwidth of 16.52 THz can be generated.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61575170 and 61675176)the Key Basic Research Program of Hebei Province,China(Grant No.16961701D)the“Xin Rui Gong Cheng”Talent Project of Yanshan University。
文摘A compact electro-absorption modulator based on graphene photonic crystal fiber is proposed. To enhance the graphene–light interaction efficiency, the innermost six air-holes of photonic crystal fiber are replaced by two large semicircular holes, and monolayer graphene is deposited on the two large semicircular holes. By optimizing the structure parameters, a strong graphene–light interaction is obtained. Moreover, the switch on–off point of the modulator is unchangeable,which is only related to the frequency of the incident light. The influence factors of this composite structure have been analyzed. The proposed modulator is compared with other graphene-based modulators, and the results show that it is filled without dielectric spacer. There are some excellent performances, such as an extinction ratio 7 dB of y-polarization mode,3-dB modulation bandwidth of 70 GHz with small footprint of 205 μm, and a consumption of energy per bit 59 pJ/bit.
文摘Efficient coupling from the silicon waveguide to the GeSi layer is the key to success in the GeSi electro-absorption （EA） modulator based on evanescent coupling. A lateral taper in the upper GeSi layer has room for increasing the modulating efficiency and alleviating the sensitivity of the extinction ratio （ER） and insertion loss （IL） to the length of the active region. The light behavior and the effect of the taper are explored in detail using the beam propagation method （BPM）. After optimization, the light can nearly be totally confined in the GeSi layer without any oscillation. The modulator with the designed taper can achieve low IL and high ER.
基金supported by the Strategic Priority Research Program of CAS(Grant No.XDB43020202)the Natural Science Foundation of China(Grant Nos.61934007,62274153,62090053).
文摘Currently,the global 5G network,cloud computing,and data center industries are experiencing rapid development.The continuous growth of data center traffic has driven the vigorous progress in high-speed optical transceivers for optical interconnection within data centers.The electro-absorption modulated laser(EML),which is widely used in optical fiber communications,data centers,and high-speed data transmission systems,represents a high-performance photoelectric conversion device.Compared to traditional directly modulated lasers(DMLs),EMLs demonstrate lower frequency chirp and higher modulation bandwidth,enabling support for higher data rates and longer transmission distances.This article introduces the composition,working principles,manufacturing processes,and applications of EMLs.It reviews the progress on advanced indium phosphide(InP)-based EML devices from research institutions worldwide,while summarizing and comparing data transmission rates and key technical approaches across various studies.
基金Related studies were supported by the National Natural Science Foundation of China(Grant No.61275067).
文摘In this paper,we proposed a novel ultra・flat broadband microwave frequency comb(MFC)generation based on optical frequency comb(OFC)with a multiplequantum-well electroabsorption modulator(MQW-EAM)in critical state.The scheme is simple and easy to adjust.The performance of the MFC generation scheme is investigated using software Optisystem.The results show that the comb spacing of MFC can be adjusted from 5 to 20 GHz by changing RF signafs frequency and the MFC is almost independent on the linewidth of the tunable laser diode.The performance of the MFC can be improved by reasonably increasing the voltage of the RF,the smallsignal gain of the Erbium-doped fiber amplifier(EDFA)and the responsivity of the photodetector.The MFC generated by this scheme has 300 GHz effective bandwidth with 15 comb lines,whose power variation is 0.02 dB,when the components9 parameters in the Optisystem are set as follows:the power of tunable laser diode(TLD)is 0 dBm,the wavelength is 1552.52 nm,and linewidth is 1 MHz;RF signaPs frequency is 20 GHz and the voltage is 10 V;the reverse bias voltage of MQW-EAM is 6.92 V;the small-signal gain of the EDFA is 40 dB;the responsivity of the photodetector(PD)is 1 A/W.
基金Scientific Research Training Program for Young Talents of Union Hospital,Tongji Medical College,Huazhong University of Science and Technology(F.W.),NIH/NIDCR grants DE029012 and DE029465Department of Defense Grant PR190899(R.T.F.)Michigan Musculoskeletal Health Core Center(NIH/NIAMS P30 AR069620)。
文摘Bone morphogenetic proteins are essential for bone regeneration/fracture healing but can also induce heterotopic ossification(HO).Understanding accessory factors modulating BMP signaling would provide both a means of enhancing BMP-dependent regeneration while preventing HO.This study focuses on the ability of the collagen receptor,discoidin domain receptor 2(DDR2),to regulate BMP activity.As will be shown,induction of bone formation by subcutaneous BMP2 implants is severely compromised in Ddr2-deficient mice.In addition,Ddr2 deficiency attenuates HO in mice expressing the ACVR1 mutation associated with human fibrodysplasia ossificans progressiva.In cells migrating into BMP2 implants,DDR2 is co-expressed with GLI1,a skeletal stem cell marker,and DDR2/GLI1-positive cells participate in BMP2-induced bone formation where they contribute to chondrogenic and osteogenic lineages.Consistent with this distribution,conditional knockout of Ddr2 in Gli1-expressing cells inhibited bone formation to the same extent seen in globally Ddr2-deficient animals.This response was explained by selective inhibition of Gli1+cell proliferation without changes in apoptosis.The basis for this DDR2 requirement was explored further using bone marrow stromal cells.Although Ddr2 deficiency inhibited BMP2-dependent chondrocyte and osteoblast differentiation and in vivo,bone formation,early BMP responses including SMAD phosphorylation remained largely intact.Instead,Ddr2 deficiency reduced the nuclear/cytoplasmic ratio of the Hippo pathway intermediates,YAP and TAZ.This suggests that DDR2 regulates Hippo pathway-mediated responses to the collagen matrix,which subsequently affect BMP responsiveness.In summary,DDR2 is an important modulator of BMP signaling and a potential therapeutic target both for enhancing regeneration and treating HO.
文摘Spatial memory is crucial for survival within external surroundings and wild environments.The hippocampus,a critical hub for spatial learning and memory formation,has received extensive investigations on how neuromodulators shape its functions(Teixeira et al.,2018;Zhang et al.,2024).However,the landscape of neuromodulations in the hippocampal system remains poorly understood because most studies focus on classical monoamine neuromodulators,such as acetylcholine,serotonin,dopamine,and noradrenaline.The neuropeptides,comprising the most abundant neuromodulators in the central nervous system,play a pivotal role in neural information processing in the hippocampal system.Cholecystokinin(CCK),one of the most abundant neuropeptides,has been implicated in regulating various physiological and neurobiological statuses(Chen et al.,2019).CCK-A receptor(CCK-AR)and CCK-B receptors(CCK-BR)are two key receptors mediating the biological functions of CCK,both of which belong to class-A sevenfold transmembrane G protein-coupled receptors(Nishimura et al.,2015).CCK-AR preferentially reacts to sulfated CCK,whereas CCK-BR binds both CCK and gastrin with similar affinities(Ding et al.,2022).The expression patterns of CCK-AR and CCK-BR are distinct,implying that CCK has various functions in target regions.For instance,CCK-AR is widely expressed in the GI and brain subregions and is hence implicated in the control of digestive function and satiety regulation.Conversely,CCK-BR is abundantly and widely distributed in the central nervous system,which majorly regulates anxiety,learning,and memory(Ding et al.,2022).However,the roles of endogenous CCK and CCK receptors in regulating hippocampal function at electrophysiological and behavioral levels have received less attention.
基金supported by funds from the Italian Ministry of Health,Ricerca Finalizzata,(Grant N.GR-2013-02355882 and GR-2021-12373946 to AL)5x1000 Project of the Istituto Superiore di Sanità(Project code:ISS5x1000_21-949432e8c9be to AL)the European Union–NextGeneration EU through the Italian Ministry of University and Research under PNRR-M4C2-I1.3 Project PE_00000019“HEAL ITALIA”to EA(CUP I83C22001830006)。
文摘Astrocytes,the main population of glial cells in the central nervous system(CNS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental stage to adult life.To maintain the optimal functionality of the brain,astroglial cells are particularly committed to reacting to every change in tissue homeostatic conditions,from mild modifications of the physiological environment,a process called astrocyte activation,to the more severe alterations occurring in pathological situations causing astrocyte reactivity or reactive astrogliosis(Escartin et al.,2021).During these reactive states,astrocytes mount an active,progressive response encompassing morphological,molecular,and interactional remodeling,leading to the acquisition of new functions and the loss of others,whose intensity,duration,and reversibility are dependent on the nature of the stimulus and regulated in a context-specific manner.
基金supported by the National Natural Science Foundation of China (Grant Nos. 61925505 and 62405070)"Pioneer" and "Leading Goose" R&D Program of Zhejiang Province (Grant No. 2024C01112)National Key Research and Development Program of China (Grant No. 2023YFB2807100)。
文摘As the demand for computing power in data centers continues to grow, balancing data transmitting speed and energy efficiency has emerged as a critical challenge. Highbandwidth, low-power interconnection schemes are increasingly recognized as core requirements for next-generation intelligent computing center designs^([1, 2]). For short-range optical interconnections of intra-chip and inter-chip—typically covering tens of meters or less—microring resonant modulators (MRM) are emerging as an ideal solution.
基金supported by grants from the Key-Area Research and Development Program of Guangdong province(2019B030335001)the National Natural Science Foundation of China(32200815)the China Postdoctoral Science Foundation(2022M721218).
文摘Based on previous experience,learning to avoid or seek certain specific stimuli again in the future is crucial for survival.Our brains are wired to assign a particular valence-either positive or negativeas a result of sensory stimuli,and it is this valence that serves as the foundational motivation for our subsequent actions.Simply put,all motivational actions fall into two categories:pleasure-seeking behavior guided by positive emotional valence,and pain-avoiding behavior driven by negative emotional valence[1].The ability to shift from one emotional valence to another is an important characteristic of affective states,while the instability of emotional states underlies many psychiatric disorders,highlighting the clinical importance of managing and understanding these fluctuations.This ability to adapt emotional responses can be attained by modulating the gain across distinct neural pathways,thus enabling the nuanced and smooth assignment of valence through the strengthening or weakening of circuit activity[1,2].
文摘With the continuous improvement of signal processing accuracy requirements in modern electronic systems,the demand for high-precision analog-to-digital converters(ADCs)is increasing.Sigma-Delta modulator,as the most important component of high-precision ADC,is widely used in high-quality audio,high-precision instrument measurement,and other fields due to its advantages of high precision,strong noise resistance,and low hardware cost.This article designs a discrete structure third-order four-bit high-precision Sigma-Delta modulator through modeling,with an oversampling rate set to 512.Under ideal conditions,the simulation results show that the SDNR reaches 152.7db and the ENOB is 25.24bits.After introducing non-ideal noise,the system performance has decreased.The simulation results show that the SDNR is as high as 124.5db and the ENOB is 20.39bits.This indicates that the design can achieve high-precision conversion and provide assistance for further research in the future.
基金Projects(51875584,51875585,51975590)supported by the National Natural Science Foundation of China。
文摘Femtosecond laser processing is an important machining method for micro-optical components such as Fresnel zone plate(FZP).However,the low processing efficiency of the femtosecond laser restricts its application.Here,a femtosecond laser Bessel beam is proposed to process micro-FZP,which is modulated from a Gaussian beam to a Bessel annular beam.The processing time for FZP with an outer diameter of 60μm is reduced from 30 min to 1.5 min on an important semiconductor material gallium arsenide(GaAs),which significantly improves the processing efficiency.In the modulation process,a central ablation hole that has an adverse effect on the diffraction performance is produced,and the adverse effect is eliminated by superimposing the blazed grating hologram.Meanwhile,the FZP machined by spatial light modulator(SLM)has good morphology and higher diffraction efficiency,which provides a strong guarantee for the application of micro-FZP in computed tomography and solar photovoltaic cells.
文摘Objectives:The phytochemical investigation of traditional herbal medicines holds significant promise for modern drug discovery,particularly in cancer therapy.This study aimed to evaluate the cytotoxicity,apoptosis induction,and immune-modulatory activities of extracts from three herbal medicines with historical use in traditional medicine—Acanthopanax sessiliflorus,Phragmites communis,and Pinus densiflora,as well as their combined extract(GMAS 01/COM),on human lung cancer cells(A549)and normal cell lines,including murine macrophages(RAW 264.7)and human keratinocytes(HaCaT).Methods:Plant extracts were prepared using aqueous extraction,sonication,and rotary evaporation.The total phenolic and flavonoid contents were quantified using the Folin-Ciocalteu and AlCl3 colorimetric methods,respectively.Antioxidant potential was evaluated via 2,2-Diphenyl-1-picrylhydrazyl(DPPH)scavenging and reducing power assays.Cytotoxicity was assessed using an MTT assay,while reactive oxygen species(ROS)generation was quantified using a 2′,7′-Dichlorodihydrofluorescein diacetate(DCFH-DA)assay.Anticancer properties,including colony formation inhibition and migration suppression,were examined using colony formation and wound healing assays.The expression of apoptotic and inflammatory mediators was analysed through qPCR.Results:GMAS 01 selectively induced apoptosis in A549 cells without cytotoxic effects on RAW264.7 and HaCaT cells.Mechanistically,it elevated intracellular ROS and activated the intrinsic mitochondrial apoptotic pathway,evidenced by p53 upregulation,increased Bax,and decreased Bcl-2 expression.GMAS 01 also significantly inhibited colony formation and migration in A549 cells.In RAW264.7 cells,it reduced nitric oxide(NO)production and downregulated iNOS,COX-2,IL-6,and IL-8,indicating strong immunomodulatory activity.Conclusion:GMAS 01 exhibits potent antioxidant,anti-inflammatory,and anticancer effects,likely mediated through ROS-induced mitochondrial apoptosis.However,mechanistic interpretations are limited by the absence of protein-level validation and pathway inhibition studies.Upcoming studies should aim to verify the underlying mechanisms and evaluate their potential for real-world application.
文摘In this paper,we present a novel first-order digitalΣΔconverter tailored for digital-to-analog applications,focusing on achieving both high yield and reduced silicon estate.Our approach incorporates a substantial level of dithering noise into the input signal,strategically aimed at mitigating the spurious frequencies commonly encountered in such converters.Validation of our design is performed through simulations using a high-level simulator specialized in mixed-signal circuit analysis.The results underscore the enhanced performance of our circuit,especially in reducing spurious frequencies,highlighting its efficiency and effectiveness.The final circuit exhibits an effective number of bits of 13.
基金supported by the Hellenic Foundation for Research and Innovation,HFRI,“2nd Call for HFRI Research Projects to support Faculty Members&Researchers”Project 02667 to GL.
文摘Lysophosphatidic acid(LPA)is a pleiotropic lipid agonist essential for functions of the central nervous system(CNS).It is abundant in the developing and adult brain while its concentration in biological fluids,including cerebrospinal fluid,varies significantly(Figure 1Α;Yung et al.,2014).LPA actually corresponds to a variety of lipid species that include different stereoisomers with either saturated or unsaturated fatty acids bearing likely differentiated biological activities(Figure 1Α;Yung et al.,2014;Hernández-Araiza et al.,2018).
