Structural properties of forest soils have important hydro-ecological function and can influence the soil water-physical characters and soil erosion. The experimental soil samples were obtained in surface horizon (0-1...Structural properties of forest soils have important hydro-ecological function and can influence the soil water-physical characters and soil erosion. The experimental soil samples were obtained in surface horizon (0-10 cm) from different subalpine forest types on east slope of Gongga Mountain in the upriver area of Yangtze River China in May 2002. The soil bulk density, porosity, stable infiltration rate, aggregate distribution and particle-size distribution were analyzed by the routine methods in room, and the features and effects on eco-environment of soil aggregation were studied. The results showed that the structure of soil under mixed mature forest is in the best condition and can clearly enhance the eco-environmental function of soil, and the soil structure under the clear-cutting forest is the worst, the others are ranked between them. The study results can offer a basic guidance for the eco-environmental construction in the upper reaches of Yangtze River.展开更多
Based on the historical records,the flood disasters in Xu-Huai River Basin caused by southward flow of Yellow River were studied,while its effects on Xu-Huai regional economic,transportation and eco-environment were a...Based on the historical records,the flood disasters in Xu-Huai River Basin caused by southward flow of Yellow River were studied,while its effects on Xu-Huai regional economic,transportation and eco-environment were also highlighted,and finally historical natural disasters were presented in this study.展开更多
Beam-tracking simulations have been extensively utilized in the study of collective beam instabilities in circular accelerators.Traditionally,many simulation codes have relied on central processing unit(CPU)-based met...Beam-tracking simulations have been extensively utilized in the study of collective beam instabilities in circular accelerators.Traditionally,many simulation codes have relied on central processing unit(CPU)-based methods,tracking on a single CPU core,or parallelizing the computation across multiple cores via the message passing interface(MPI).Although these approaches work well for single-bunch tracking,scaling them to multiple bunches significantly increases the computational load,which often necessitates the use of a dedicated multi-CPU cluster.To address this challenge,alternative methods leveraging General-Purpose computing on Graphics Processing Units(GPGPU)have been proposed,enabling tracking studies on a standalone desktop personal computer(PC).However,frequent CPU-GPU interactions,including data transfers and synchronization operations during tracking,can introduce communication overheads,potentially reducing the overall effectiveness of GPU-based computations.In this study,we propose a novel approach that eliminates this overhead by performing the entire tracking simulation process exclusively on the GPU,thereby enabling the simultaneous processing of all bunches and their macro-particles.Specifically,we introduce MBTRACK2-CUDA,a Compute Unified Device Architecture(CUDA)ported version of MBTRACK2,which facilitates efficient tracking of single-and multi-bunch collective effects by leveraging the full GPU-resident computation.展开更多
Land use/land cover change (LUCC) is a focus of the research of global environmental changes. The middle and upper reaches of the Yangtze River, which are the most ecologically fragile mountainous area in China as wel...Land use/land cover change (LUCC) is a focus of the research of global environmental changes. The middle and upper reaches of the Yangtze River, which are the most ecologically fragile mountainous area in China as well as one of the areas in China with most notable LUCC, have been on the Chinese Government's list of priority areas for ecological restoration. This paper is to reveal the trend of LUCC and the ecological degradation arising from it, and to provide a basis for the future sustainable use of land resources in the region based on a detailed analysis of Yiliang County. Based on the county's land use/cover maps in 1960, 1980 and 2000 drawn with the aid of aerial photograph interpretation, field investigation and GIS based spatial-temporal data analysis, LUCC during 1960~2000 period and the ecological degradation arising from it were analyzed. Using the Markv model, the paper brings out a forecast of what the county's LUCC would be like if the county's current land use continues, as well as the reasons and countermeasures for restoring degraded ecosystems.展开更多
Global urbanization is exerting severe stress and having far-reaching impacts on the eco-environment, and yet there exists a complex non-linear coupling relationship between the two. Research on the interactive coupli...Global urbanization is exerting severe stress and having far-reaching impacts on the eco-environment, and yet there exists a complex non-linear coupling relationship between the two. Research on the interactive coupling effect between urbanization and the eco-environment will be a popular area of study and frontier in international earth system science and sustainability science in the next 10 years, while also being a high-priority research topic of particular interest to international organizations. This paper systematically collates and summarizes the international progress made in research on interactive coupling theory, coupling relationships, coupling mechanisms, coupling laws, coupling thresholds, coupling models and coupling optimization decision support systems. The research shows that urbanization and eco-environment interactive coupling theories include the Kuznets curve theory, telecoupling theory, planetary boundaries theory, footprint family theory and urban metabolism theory; most research on interactive coupling relationships is concerned with single- element coupling relationships, such as those between urbanization and water, land, atmosphere, climate change, ecosystems and biodiversity; the majority of research on interactive coupling mechanisms and laws focuses on five research paradigms, including coupled human and nature systems, complex social-ecological systems, urban ecosystems, social-economic-natural complex ecosystems, and urbanization development and eco-environment constraint ring; the majority of interactive coupling simulations use STIRPAT models, coupling degree models, multi-agent system models and big data urban computer models; and research has been carried out on urbanization and eco-environment coupling thresholds, coercing risk and optimal decision support systems. An objective evaluation of progress in international research on interactive coupling between urbanization and the eco-environment suggests that there are six main research focal points and six areas lacking research： a lot of research exists on macroscopic coupling effects, with little research on urban agglomeration and scale coupling effects; considerable research exists on sin-gle-dimension coupling effects, with little on multiple-dimension coupling effects; a great deal exists on ＂one-to-one＂ dual- element coupling effects, with little on ＂many-to-many＂ multiple-element coupling effects; a lot exists on positive feedback coupling effects, and little on negative feedback coupling effects; a great deal exists on empirical coupling effects, and little on theoretical coupling effects; a great deal exists on the use of simple quantitative methods, and little on using integrated simulation methods. Future studies should focus on coupling effects between urbanization in urban agglomerations and the eco-environment, spatial scale coupling effects, multi-dimensional coupling effects, telecoupling effects, ＂one-to-many＂ and ＂many-to-many＂ element coupling effects, and positive and negative feedback coupling effects. There is also a need to strengthen the development and application of dynamic models for multi-element,-scale,-scenario,-module and-agent integrated spatiotemporal coupling systems and further improve theoretical innovations in coupling effect research and integrate and form complete and diverse coupling theoretical systems.展开更多
Mega-urban agglomerations are strategic core areas for national economic development and the main regions of new urbanization. They also have important roles in shifting the global economic center of gravity to China....Mega-urban agglomerations are strategic core areas for national economic development and the main regions of new urbanization. They also have important roles in shifting the global economic center of gravity to China. However, the development of mega-urban agglomerations has triggered the interactive coercion between resources and the eco-envi- ronment. The interactive coupled effects between urbanization and the eco-environment in mega-urban agglomerations represent frontier and high-priority research topics in the field of Earth system science over the next decade. In this paper, we carried out systematic theo- retical analysis of the interactive coupling mechanisms and coercing effects between ur- banization and the eco-environment in mega-urban agglomerations. In detail, we analyzed the nonlinear-coupled relationships and the coupling characteristics between natural and human elements in mega-urban agglomerations. We also investigated the interactive coercion intensities between internal and external elements, and the mechanisms and patterns of local couplings and telecouplings in mega-urban agglomeration systems, which are affected by key internal and external control elements. In addition, we proposed the interactive coupling theory on urbanization and the eco-environment in mega-urban agglomerations. Furthermore we established a spatiotemporal dynamic coupling model with multi-element, multi-scale, multi-scenario, multi-module and multi-agent integrations, which can be used to develop an intelligent decision support system for sustainable development of mega-urban agglomera- tions. In general, our research may provide theoretical guidance and method support to solve problems related to mega-urban agglomerations and maintain their sustainable development.展开更多
In winter 2018,an aerosol physicochemical experiment was conducted in the Western Pacific Ocean(WPO)aboard the Research Vessel KEXUE of Chinese Academy of Sciences.This study systematically investigated both natural a...In winter 2018,an aerosol physicochemical experiment was conducted in the Western Pacific Ocean(WPO)aboard the Research Vessel KEXUE of Chinese Academy of Sciences.This study systematically investigated both natural and anthropogenic effects on marine aerosols optical properties,as well as the applicability of multi-satellite products and IMPROVE equation.The averaged aerosol optical depth(AOD500 nm)was 0.31±0.16 andÅngström exponent440–675 nm was 0.29±0.30.In offshore China,significant anthropogenic emissions affected the marine environment.In remote WPO,dust aerosols transported from northern China,Siberia,Central Asia,and those settling from the upper troposphere originating from north Africa,Arabian peninsula,and western India,were dominant.The spatial trends of AOD were opposite in the mid-latitude and southern seas of WPO.The highest AOD,0.32±0.23,appeared along the coast of South Asia at mid-latitude,decreasing from offshore seas to remote oceans.In low-latitude and equatorial seas,AOD significantly increased from coast to remote oceans.Ångström exponent dropped significantly from the coast to remote oceans as anthropogenic influence diminished across the entire WPO.Correlation analysis showed that both MODIS-C6 and Himawari AOD prod-ucts showed similar applicability in coastal urban areas,while Himawari AOD is highly recommended for coastal background and marine environment due to its finer resolution.The extinction coefficient derived from PM_(2.5) chemical compositions using IMPROVE algorithm exhibited a significant correlation(R^(2)=0.58)with the con-currently measured AOD in the absence of long-distance transport,suggesting that the IMPROVE is a reasonable proxy of the columnar average of marine aerosol extinctions free from transport influences.展开更多
With the artificial alder and cypress mixed forest being planted, there has been a marked land use change since 1970s' in Hilly Area of Central Sichuan Basin, China. Data from meteorological observations or posts ...With the artificial alder and cypress mixed forest being planted, there has been a marked land use change since 1970s' in Hilly Area of Central Sichuan Basin, China. Data from meteorological observations or posts operated over long time, measurement and calculation of NPP (net primary production) and biomass of biological community, and analysis of soil organic matter content show that the artificial alder and cypress mixed forest has outstanding eco-environmental effect: adjusting local climate, raising soil fertility, alleviating menace of drought, and raising NPP and biomass of biological community. It is very beneficial for improving ecological environment to afforest artificial alder and cypress mixed forest in populous Hilly Area of Central Sichuan Basin, China. Key Words: land use/land cover change (LUCC); eco-environmental effect; Hilly Area of Central Sichuan Basin; the artificial alder and cypress mixed forest展开更多
Objectively, a complex interactive coercing relationship exists between urbanization and eco-environment, and the research of this relationship is primarily divided into three schools, i.e., interactive coercion theor...Objectively, a complex interactive coercing relationship exists between urbanization and eco-environment, and the research of this relationship is primarily divided into three schools, i.e., interactive coercion theory, interactive promotion theory and coupling symbiosis theory. Harmonizing the relationship between urbanization and eco-environment is not only an important proposition for the national development plan but also the only way to promote healthy urbanization. Based on an analysis of urbanization process and its relationship with the eco-environment, this article analyzes interactive coercing effects between urbanization and eco-environment from three perspectives of population urbanization, economic urbanization and spatial urbanization, respectively, and analyzes risk effects of the interactive coercion. Further, it shows six basic laws followed by interactive coercion between urbanization and eco-environment, namely, coupling fission law, dynamic hierarchy law, stochastic fluctuation law, non-linear synergetic law, threshold value law and forewarning law, and divides the interactive coercing process into five stages, namely, low-level coordinate, antagonistic, break-in, ameliorative and high-grade coordinate. Based on the geometric derivation, the interactive coercing relationship between urbanization and eco-environment is judged to be non-linear and it can be explained by a double-exponential function formed by the combination of power and exponential functions. Then, the evolutionary types of the interactive coercing relationship are divided into nine ones: rudimentary coordinating, ecology-dominated, synchronal coordinating, urbanization lagging, stepwise break-in, exorbitant urbanization, fragile ecology, rudimentary break-in and unsustainable types. Finally, based on an interactive coercion model, the degree of interactive coercion can be examined, and then, an evolutionary cycle can be divided into four phases, namely rudimentary symbiosis, harmonious development, utmost increasing and spiral type rising. The study results offer a scientific decision-making of healthy urbanization for achieving the goal of eco-environment protection and promoting urbanization.展开更多
Lithium metal batteries(LMBs)have been regarded as one of the most promising alternatives in the post-lithium battery era due to their high energy density,which meets the needs of light-weight electronic devices and l...Lithium metal batteries(LMBs)have been regarded as one of the most promising alternatives in the post-lithium battery era due to their high energy density,which meets the needs of light-weight electronic devices and long-range electric vehicles.However,technical barriers such as dendrite growth and poor Li plating/stripping reversibility severely hinder the practical application of LMBs.However,lithium nitrate(LiNO_(3))is found to be able to stabilize the Li/electrolyte interface and has been used to address the above challenges.To date,considerable research efforts have been devoted toward understanding the roles of LiNO_(3) in regulating the surface properties of Li anodes and toward the development of many effective strategies.These research efforts are partially mentioned in some articles on LMBs and yet have not been reviewed systematically.To fill this gap,we discuss the recent advances in fundamental and technological research on LiNO_(3) and its derivatives for improving the performances of LMBs,particularly for Li-sulfur(S),Li-oxygen(O),and Li-Li-containing transition-metal oxide(LTMO)batteries,as well as LiNO_(3)-containing recipes for precursors in battery materials and interphase fabrication.This review pays attention to the effects of LiNO_(3) in lithium-based batteries,aiming to provide scientific guidance for the optimization of electrode/electrolyte interfaces and enrich the design of advanced LMBs.展开更多
The living circumstances of human beings are closely related to the geological environment. As exemplified by the Zhangjiakou-West Beijing region, this paper describes the intensive mantle-crust uplift, which led to a...The living circumstances of human beings are closely related to the geological environment. As exemplified by the Zhangjiakou-West Beijing region, this paper describes the intensive mantle-crust uplift, which led to anomalous element background values for regional rocks (ores) and soils. As a result, some agricultural crops, and forests and fruits are of “super-quality and high yield” or of “poor quality and low yield”. The anomalous elements can find their way into grains, fruits, vegetables and drinking water and then will be taken by human beings, constituting a food chain, which would directly impact human health and lead to the spread of some endemic diseases. Studies have shown that the geomorphological features in the Zhangjiakou-West Beijing region are the outcome of geotectonic evolution since the Mesozoic. Mantle-crust movement is the key factor leading to the evolution and change of the regionally geological environment.展开更多
Multidimensional confined structure systems are proposed and demonstrated by using MoO_(2)@MO_(2)C(MMC)to enhance the photothermal catalytic performance of the metal sulfides-multidimensional confined structure(TMs-MD...Multidimensional confined structure systems are proposed and demonstrated by using MoO_(2)@MO_(2)C(MMC)to enhance the photothermal catalytic performance of the metal sulfides-multidimensional confined structure(TMs-MDCS).Specifically,the MMC nanoparticles confined to the surface of the ZnIn_(2)S_(4)hollow tube-shell(MMC/HT-ZIS)achieve a hydrogen evolution rate of 9.72 mmol g^(-1)h^(-1),which is 11.2 times higher than that of pure HT-ZIS.Meanwhile,the MnCdS(MCS)nanoparticles are encapsulated within the two-dimensional MMC(2D MMC/MCS)through precise regulation of size and morphology.The 10-MMC/MCS lamellar network demonstrates the highest hydrogen evolution rate of 8.19 mmol g^(-1)-h^(-1).The obtained MMC/TMs-MDCS catalysts exhibit an enhanced photocatalytic hydrogen evolution rate,which can be attributed to the strong synergistic interaction between the multidimensional confinement and the photothermal effects.The confinement space and the strong interfacial relationship within the MMC/TMs-MDCS create abundant channels and active sites that facilitate electron migration and transport.Furthermore,the construction of a confined environment positions these materials as promising candidates for achieving exceptional photothermal catalytic performance,as MMC/TMs-MDCS enhance light absorption through light scattering and reflecting effects.Additionally,the capacity of MMC/TMsMDCS to convert solar light into thermal energy significantly reduces the activation energy of the reaction,thereby facilitating reaction kinetics and accelerating the separation and transport of photogenerated carriers.This work provides valuable insights for the development of highly efficient photothermal catalytic water-splitting systems for hydrogen production using multidimensional confined catalysts.展开更多
Agricultural intensification has led to an increase in monoculture and the use of chemical pesticides,resulting in a decline in biodiversity and a reduction in ecosystem services,particularly biological pest managemen...Agricultural intensification has led to an increase in monoculture and the use of chemical pesticides,resulting in a decline in biodiversity and a reduction in ecosystem services,particularly biological pest management.However,studies have shown that agroforestry can not only improve land productivity and biodiversity but also regulate some ecosystem services.This study reviews the impacts of physical and biological factors on herbivorous pests,parasites,and predatory natural enemies in fruit-crop agroforestry systems.Fruit-crop agroforestry systems provide high spatial heterogeneity by altering crop layouts,regulating the microclimate and soil quality,and offering food resources and shelter for natural enemies,thus promoting biological pest control.This enhances biological control and makes the agrocomplex system an effective tool for sustainable agriculture.Our research shows that volatile plant substances attract or repel pests and natural enemies based on the characteristics of the insects themselves.When scientifically designed,fruit-crop agroforestry systems provide high spatial heterogeneity and favorable microclimatic conditions,which enhance biological pest control and make the agroforestry system an effective tool for sustainable agriculture.Our research shows that fruit-crop agroforestry systems can provide richer food resources and habitat,enhancing biological pest control and improving pest management.展开更多
Fertilization or atmospheric deposition of nitrogen(N)and phosphorus(P)to terrestrial ecosystems can alter soil N(P)availability and the nature of nutrient limitation for plant growth.Changing the allocation of leaf P...Fertilization or atmospheric deposition of nitrogen(N)and phosphorus(P)to terrestrial ecosystems can alter soil N(P)availability and the nature of nutrient limitation for plant growth.Changing the allocation of leaf P fractions is potentially an adaptive strategy for plants to cope with soil N(P)availability and nutrient-limiting conditions.However,the impact of the interactions between imbalanced anthropogenic N and P inputs on the concentrations and allocation proportions of leaf P fractions in forest woody plants remains elusive.We conducted a metaanalysis of data about the concentrations and allocation proportions of leaf P fractions,specifically associated with individual and combined additions of N and P in evergreen forests,the dominant vegetation type in southern China where the primary productivity is usually considered limited by P.This assessment allowed us to quantitatively evaluate the effects of N and P additions alone and interactively on leaf P allocation and use strategies.Nitrogen addition(exacerbating P limitation)reduced the concentrations of leaf total P and different leaf P fractions.Nitrogen addition reduced the allocation to leaf metabolic P but increased the allocation to other fractions,while P addition showed opposite trends.The simultaneous additions of N and P showed an antagonistic(mutual suppression)effect on the concentrations of leaf P fractions,but an additive(summary)effect on the allocation proportions of leaf P fractions.These results highlight the importance of strategies of leaf P fraction allocation in forest plants under changes in environmental nutrient availability.Importantly,our study identified critical interactions associated with combined N and P inputs that affect leaf P fractions,thus aiding in predicting plant acclimation strategies in the context of intensifying and imbalanced anthropogenic nutrient inputs.展开更多
The past decade has witnessed the rapid increasement in power conversion efficiency of perovskite solar cells(PSCs).However,serious ion migration hampers their operational stability.Although dopants composed of varied...The past decade has witnessed the rapid increasement in power conversion efficiency of perovskite solar cells(PSCs).However,serious ion migration hampers their operational stability.Although dopants composed of varied cations and anions are introduced into perovskite to suppress ion migration,the impact of cations or anions is not individually explored,which hinders the evaluation of different cations and further application of doping strategy.Here we report that a special group of sulfonic anions(like CF_(3)SO_(3)^(-))successfully introduce alkaline earth ions(like Ca^(2+))into perovskite lattice compared to its halide counterparts.Furthermore,with effective crystallization regulation and defect passivation of sulfonic anions,perovskite with Ca(CF_(3)SO_(3))_(2)shows reduced PbI2 residue and metallic Pb0 defects;thereby,corresponding PSCs show an enhanced PCE of 24.95%.Finally by comparing the properties of perovskite with Ca(CF_(3)SO_(3))_(2)and FACF_(3)SO_(3),we found that doped Ca^(2+)significantly suppressed halide migration with an activation energy of 1.246 eV which accounts for the improved operational stability of Ca(CF_(3)SO_(3))_(2-)doped PSCs,while no obvious impact of Ca^(2+)on trap density is observed.Combining the benefits of cations and anions,this study presents an effective method to decouple the effects of cations and anions and fabricate efficient and stable PSCs.展开更多
Objective The use of lasers has been an important part of urology in the treatment of stone and prostate disease.The thermal effects of lasers in lithotripsy have been a subject of debate over the years.The objective ...Objective The use of lasers has been an important part of urology in the treatment of stone and prostate disease.The thermal effects of lasers in lithotripsy have been a subject of debate over the years.The objective of this review was to assess the current state of knowledge available on the thermal effects of lasers in lithotripsy,as well as explore any new areas where studies are needed.Methods In August 2022,a keyword search on Google Scholar,PubMed,and Scopus for all papers containing the phrases“thermal effects”AND“laser”AND“lithotripsy”AND“urology”was done followed by citation jumping to other studies pertaining to the topic and 35 relevant papers were included in our study.The data from relevant papers were segregated into five groups according to the factor studied and type of study,and tables were created for a comparison of data.Results Temperature above the threshold of 43℃ was reached only when the power was>40 W and when there was adequate irrigation(at least 15–30 mL/min).Shorter lasing time divided by lithotripsy time or operator duty cycles less than 70%also resulted in a smaller temperature rise.Conclusion At least eight factors modify the thermal effects of lasers,and most importantly,the use of chilled irrigation at higher perfusion rates,lower power settings of<40 W,and with a shorter operator duty cycle will help to prevent thermal injuries from occurring.Stones impacted in the ureter or pelvi-ureteric junction further increase the probability of thermal injuries during laser firing.展开更多
Exosomes(Exos)are extracellular vesicles secreted by cells and serve as crucial mediators of intercellular communication.They play a pivotal role in the pathogenesis and progression of various diseases and offer promi...Exosomes(Exos)are extracellular vesicles secreted by cells and serve as crucial mediators of intercellular communication.They play a pivotal role in the pathogenesis and progression of various diseases and offer promising avenues for therapeutic interventions.Exos derived from mesenchymal stem cells(MSCs)have significant immunomodulatory properties.They effectively regulate immune responses by modulating both innate and adaptive immunity.These Exos can inhibit excessive inflammatory responses and promote tissue repair.Moreover,they participate in antigen presentation,which is essential for activating immune responses.The cargo of these Exos,including ligands,proteins,and microRNAs,can suppress T cell activity or enhance the population of immunosuppressive cells to dampen the immune response.By inhibiting lymphocyte proliferation,acting on macrophages,and increasing the population of regulatory T cells,these Exos contribute to maintaining immune and metabolic homeostasis.Furthermore,they can activate immune-related signaling pathways or serve as vehicles to deliver microRNAs and other bioactive substances to target tumor cells,which holds potential for immunotherapy applications.Given the immense therapeutic potential of MSC-derived Exos,this review comprehensively explores their mechanisms of immune regulation and therapeutic applications in areas such as infection control,tumor suppression,and autoimmune disease management.This article aims to provide valuable insights into the mechanisms behind the actions of MSC-derived Exos,offering theoretical references for their future clinical utilization as cell-free drug preparations.展开更多
Excellent progress has been made in the last few decades in the cure rates of pediatric malignancies,with more than 80%of children with cancer who have access to contemporary treatment being cured.However,the therapie...Excellent progress has been made in the last few decades in the cure rates of pediatric malignancies,with more than 80%of children with cancer who have access to contemporary treatment being cured.However,the therapies responsible for this survival can also produce adverse physical and psychological long-term outcomes,referred to as late effects,which appear months to years after the completion of cancer treatment.Research has shown that 60%to 90%of childhood cancer survivors(CCSs)develop one or more chronic health conditions,and 20%to 80%of survivors experience severe or life-threatening complications during adulthood.Therefore,understanding the late side effects of such treatments is important to improve the health and quality of life of the growing population of CCSs.展开更多
BACKGROUND Sensitivity to stress is essential in the onset,clinical symptoms,course,and prognosis of major depressive disorder(MDD).Meanwhile,it was unclear how variously classified but connected stress-sensitivity va...BACKGROUND Sensitivity to stress is essential in the onset,clinical symptoms,course,and prognosis of major depressive disorder(MDD).Meanwhile,it was unclear how variously classified but connected stress-sensitivity variables affect MDD.We hypothesize that high-level trait-and state-related stress-sensitivity factors may have different cumulative effects on the clinical symptoms and follow-up outcomes of MDD.AIM To investigate how stress-sensitivity factors added up and affected MDD clinical symptoms and follow-up results.METHODS In this prospective study,281 MDD patients were enrolled from a tertiary care setting.High-level stress-sensitivity factors were classified as trait anxiety,state anxiety,perceived stress,and neuroticism,with a total score in the top quartile of the research cohort.The cumulative effects of stress-sensitivity factors on cognitive dysfunction,disability and functional impairment,suicide risk,and depressive and anxiety symptoms were examined using an analysis of variance with linear trend analysis.Correlations were investigated further using multiple regression analysis.RESULTS Regarding high-level stress-sensitivity factors,53.40%of patients had at least one at baseline,and 29.61%had two or more.Four high-level stress-sensitivity components had significant cumulative impacts on MDD symptoms at baseline(all P<0.001).Perceived stress predicted the greatest effect sizes of state-related factors on depressive symptoms(partialη^(2)=0.153;standardizedβ=0.195;P<0.05).The follow-up outcomes were significantly impacted only by the high-level trait-related components,mainly when it came to depressive symptoms and suicide risk,which were predicted by trait anxiety and neuroticism,respectively(partialη^(2)=0.204 and 0.156;standardizedβ=0.247 and 0.392;P<0.05).CONCLUSION To enhance outcomes of MDD and lower the suicide risk,screening for stress-sensitivity factors and considering multifaceted measures,mainly focusing on trait-related ones,should be addressed clinically.展开更多
Alloying and interface effects are effective strategies for enhancing the performance of electrocatalysts in energy-related devices.Herein,dendritic Au-doped platinum-palladium alloy/dumbbell-like bismuth telluride he...Alloying and interface effects are effective strategies for enhancing the performance of electrocatalysts in energy-related devices.Herein,dendritic Au-doped platinum-palladium alloy/dumbbell-like bismuth telluride heterostructures(denoted PtPdAu/BiTe)were synthesized using a visible-light-assisted strategy.The coupling alloy and interfacial effects of PtPdAu/BiTe significantly improved the performance and stability of both the ethanol oxidation reaction(EOR)and methanol oxidation reaction(MOR).Introducing a small amount of Au effectively enhanced the CO tolerance of PtPdAu/BiTe compared to dendritic platinum-palladium alloy/dumbbell-like bismuth telluride heterostructures.PtPdAu/BiTe exhibited mass activities of 31.5 and 13.3 A·mg_(Pt)^(-1)in EOR and MOR,respectively,which were 34.4 and 13.2 times higher than those of commercial Pt black,revealing efficient Pt atom utilization.In-situ Fourier transform infrared spectroscopy demonstrated complete 12e^(-)and 6e^(-)oxidation of ethanol and methanol on PtPdAu/BiTe.The PtPdAu/BiTe/C achieved mass peak power densities of 131 and 156 mW·mg_(Pt)^(-1),which were 2.4 and 2.2 times higher than those of Pt/C in practical direct ethanol fuel cell(DEFC)and direct methanol fuel cell(DMFC),respectively,highlighting their potential application in DEFC and DMFC.This study introduces an effective strategy for designing efficient and highly CO tolerant anodic electrocatalysts for practical DEFC and DMFC applications.展开更多
基金This study was supported by the Knowledge innovation project of Chinese Academy of Sciences (KZCX2-Sw-319)
文摘Structural properties of forest soils have important hydro-ecological function and can influence the soil water-physical characters and soil erosion. The experimental soil samples were obtained in surface horizon (0-10 cm) from different subalpine forest types on east slope of Gongga Mountain in the upriver area of Yangtze River China in May 2002. The soil bulk density, porosity, stable infiltration rate, aggregate distribution and particle-size distribution were analyzed by the routine methods in room, and the features and effects on eco-environment of soil aggregation were studied. The results showed that the structure of soil under mixed mature forest is in the best condition and can clearly enhance the eco-environmental function of soil, and the soil structure under the clear-cutting forest is the worst, the others are ranked between them. The study results can offer a basic guidance for the eco-environmental construction in the upper reaches of Yangtze River.
基金Supported by Social Science Fund in Jiangsu Province " Study on evolution of Yellow River s flooding into the Huihe River and natural systems in Northern Jiangsu" (09LSA001)~~
文摘Based on the historical records,the flood disasters in Xu-Huai River Basin caused by southward flow of Yellow River were studied,while its effects on Xu-Huai regional economic,transportation and eco-environment were also highlighted,and finally historical natural disasters were presented in this study.
基金supported by the National Research Foundation of Korea(NRF)funded by the Ministry of Science and ICT(MSIT)(No.RS-2022-00143178)the Ministry of Education(MOE)(Nos.2022R1A6A3A13053896 and 2022R1F1A1074616),Republic of Korea.
文摘Beam-tracking simulations have been extensively utilized in the study of collective beam instabilities in circular accelerators.Traditionally,many simulation codes have relied on central processing unit(CPU)-based methods,tracking on a single CPU core,or parallelizing the computation across multiple cores via the message passing interface(MPI).Although these approaches work well for single-bunch tracking,scaling them to multiple bunches significantly increases the computational load,which often necessitates the use of a dedicated multi-CPU cluster.To address this challenge,alternative methods leveraging General-Purpose computing on Graphics Processing Units(GPGPU)have been proposed,enabling tracking studies on a standalone desktop personal computer(PC).However,frequent CPU-GPU interactions,including data transfers and synchronization operations during tracking,can introduce communication overheads,potentially reducing the overall effectiveness of GPU-based computations.In this study,we propose a novel approach that eliminates this overhead by performing the entire tracking simulation process exclusively on the GPU,thereby enabling the simultaneous processing of all bunches and their macro-particles.Specifically,we introduce MBTRACK2-CUDA,a Compute Unified Device Architecture(CUDA)ported version of MBTRACK2,which facilitates efficient tracking of single-and multi-bunch collective effects by leveraging the full GPU-resident computation.
基金the result of the project(No.400610o6)funded by the National Natural Science Foundation of China.
文摘Land use/land cover change (LUCC) is a focus of the research of global environmental changes. The middle and upper reaches of the Yangtze River, which are the most ecologically fragile mountainous area in China as well as one of the areas in China with most notable LUCC, have been on the Chinese Government's list of priority areas for ecological restoration. This paper is to reveal the trend of LUCC and the ecological degradation arising from it, and to provide a basis for the future sustainable use of land resources in the region based on a detailed analysis of Yiliang County. Based on the county's land use/cover maps in 1960, 1980 and 2000 drawn with the aid of aerial photograph interpretation, field investigation and GIS based spatial-temporal data analysis, LUCC during 1960~2000 period and the ecological degradation arising from it were analyzed. Using the Markv model, the paper brings out a forecast of what the county's LUCC would be like if the county's current land use continues, as well as the reasons and countermeasures for restoring degraded ecosystems.
基金Major Program of the National Natural Science Foundation of China,No.41590840,No.41590842
文摘Global urbanization is exerting severe stress and having far-reaching impacts on the eco-environment, and yet there exists a complex non-linear coupling relationship between the two. Research on the interactive coupling effect between urbanization and the eco-environment will be a popular area of study and frontier in international earth system science and sustainability science in the next 10 years, while also being a high-priority research topic of particular interest to international organizations. This paper systematically collates and summarizes the international progress made in research on interactive coupling theory, coupling relationships, coupling mechanisms, coupling laws, coupling thresholds, coupling models and coupling optimization decision support systems. The research shows that urbanization and eco-environment interactive coupling theories include the Kuznets curve theory, telecoupling theory, planetary boundaries theory, footprint family theory and urban metabolism theory; most research on interactive coupling relationships is concerned with single- element coupling relationships, such as those between urbanization and water, land, atmosphere, climate change, ecosystems and biodiversity; the majority of research on interactive coupling mechanisms and laws focuses on five research paradigms, including coupled human and nature systems, complex social-ecological systems, urban ecosystems, social-economic-natural complex ecosystems, and urbanization development and eco-environment constraint ring; the majority of interactive coupling simulations use STIRPAT models, coupling degree models, multi-agent system models and big data urban computer models; and research has been carried out on urbanization and eco-environment coupling thresholds, coercing risk and optimal decision support systems. An objective evaluation of progress in international research on interactive coupling between urbanization and the eco-environment suggests that there are six main research focal points and six areas lacking research： a lot of research exists on macroscopic coupling effects, with little research on urban agglomeration and scale coupling effects; considerable research exists on sin-gle-dimension coupling effects, with little on multiple-dimension coupling effects; a great deal exists on ＂one-to-one＂ dual- element coupling effects, with little on ＂many-to-many＂ multiple-element coupling effects; a lot exists on positive feedback coupling effects, and little on negative feedback coupling effects; a great deal exists on empirical coupling effects, and little on theoretical coupling effects; a great deal exists on the use of simple quantitative methods, and little on using integrated simulation methods. Future studies should focus on coupling effects between urbanization in urban agglomerations and the eco-environment, spatial scale coupling effects, multi-dimensional coupling effects, telecoupling effects, ＂one-to-many＂ and ＂many-to-many＂ element coupling effects, and positive and negative feedback coupling effects. There is also a need to strengthen the development and application of dynamic models for multi-element,-scale,-scenario,-module and-agent integrated spatiotemporal coupling systems and further improve theoretical innovations in coupling effect research and integrate and form complete and diverse coupling theoretical systems.
基金The Major Program of National Natural Science Foundation of China, No.41590840, No.41590842
文摘Mega-urban agglomerations are strategic core areas for national economic development and the main regions of new urbanization. They also have important roles in shifting the global economic center of gravity to China. However, the development of mega-urban agglomerations has triggered the interactive coercion between resources and the eco-envi- ronment. The interactive coupled effects between urbanization and the eco-environment in mega-urban agglomerations represent frontier and high-priority research topics in the field of Earth system science over the next decade. In this paper, we carried out systematic theo- retical analysis of the interactive coupling mechanisms and coercing effects between ur- banization and the eco-environment in mega-urban agglomerations. In detail, we analyzed the nonlinear-coupled relationships and the coupling characteristics between natural and human elements in mega-urban agglomerations. We also investigated the interactive coercion intensities between internal and external elements, and the mechanisms and patterns of local couplings and telecouplings in mega-urban agglomeration systems, which are affected by key internal and external control elements. In addition, we proposed the interactive coupling theory on urbanization and the eco-environment in mega-urban agglomerations. Furthermore we established a spatiotemporal dynamic coupling model with multi-element, multi-scale, multi-scenario, multi-module and multi-agent integrations, which can be used to develop an intelligent decision support system for sustainable development of mega-urban agglomera- tions. In general, our research may provide theoretical guidance and method support to solve problems related to mega-urban agglomerations and maintain their sustainable development.
基金supported by the CAS Strategic Priority Research Program(No.XDB0760102),the Ministry of Science and Technology of China(No.2022YFF0802501)the Major Science and Technology Infrastructure Maintenance and Transformation Project of the Chinese Academy of Sciences,Shanghai Science and Technology Innovation Action Plan-Phospherus Project(No.23YF1426200)the National Key Research and Development Program of China(No.2024YFE0212200).
文摘In winter 2018,an aerosol physicochemical experiment was conducted in the Western Pacific Ocean(WPO)aboard the Research Vessel KEXUE of Chinese Academy of Sciences.This study systematically investigated both natural and anthropogenic effects on marine aerosols optical properties,as well as the applicability of multi-satellite products and IMPROVE equation.The averaged aerosol optical depth(AOD500 nm)was 0.31±0.16 andÅngström exponent440–675 nm was 0.29±0.30.In offshore China,significant anthropogenic emissions affected the marine environment.In remote WPO,dust aerosols transported from northern China,Siberia,Central Asia,and those settling from the upper troposphere originating from north Africa,Arabian peninsula,and western India,were dominant.The spatial trends of AOD were opposite in the mid-latitude and southern seas of WPO.The highest AOD,0.32±0.23,appeared along the coast of South Asia at mid-latitude,decreasing from offshore seas to remote oceans.In low-latitude and equatorial seas,AOD significantly increased from coast to remote oceans.Ångström exponent dropped significantly from the coast to remote oceans as anthropogenic influence diminished across the entire WPO.Correlation analysis showed that both MODIS-C6 and Himawari AOD prod-ucts showed similar applicability in coastal urban areas,while Himawari AOD is highly recommended for coastal background and marine environment due to its finer resolution.The extinction coefficient derived from PM_(2.5) chemical compositions using IMPROVE algorithm exhibited a significant correlation(R^(2)=0.58)with the con-currently measured AOD in the absence of long-distance transport,suggesting that the IMPROVE is a reasonable proxy of the columnar average of marine aerosol extinctions free from transport influences.
基金Supported by the Knowledge Innovation Program of Chinese Academy of Sciences(KZCX1-SW-01-01B)Cultivatlon Foundation of Institute of Mountain Hazards and Environment,CAS
文摘With the artificial alder and cypress mixed forest being planted, there has been a marked land use change since 1970s' in Hilly Area of Central Sichuan Basin, China. Data from meteorological observations or posts operated over long time, measurement and calculation of NPP (net primary production) and biomass of biological community, and analysis of soil organic matter content show that the artificial alder and cypress mixed forest has outstanding eco-environmental effect: adjusting local climate, raising soil fertility, alleviating menace of drought, and raising NPP and biomass of biological community. It is very beneficial for improving ecological environment to afforest artificial alder and cypress mixed forest in populous Hilly Area of Central Sichuan Basin, China. Key Words: land use/land cover change (LUCC); eco-environmental effect; Hilly Area of Central Sichuan Basin; the artificial alder and cypress mixed forest
基金Under the auspices of Key Project of National Natural Science Foundation of China (No. 40335049),National Natural Science Foundation of China (No. 40971101)
文摘Objectively, a complex interactive coercing relationship exists between urbanization and eco-environment, and the research of this relationship is primarily divided into three schools, i.e., interactive coercion theory, interactive promotion theory and coupling symbiosis theory. Harmonizing the relationship between urbanization and eco-environment is not only an important proposition for the national development plan but also the only way to promote healthy urbanization. Based on an analysis of urbanization process and its relationship with the eco-environment, this article analyzes interactive coercing effects between urbanization and eco-environment from three perspectives of population urbanization, economic urbanization and spatial urbanization, respectively, and analyzes risk effects of the interactive coercion. Further, it shows six basic laws followed by interactive coercion between urbanization and eco-environment, namely, coupling fission law, dynamic hierarchy law, stochastic fluctuation law, non-linear synergetic law, threshold value law and forewarning law, and divides the interactive coercing process into five stages, namely, low-level coordinate, antagonistic, break-in, ameliorative and high-grade coordinate. Based on the geometric derivation, the interactive coercing relationship between urbanization and eco-environment is judged to be non-linear and it can be explained by a double-exponential function formed by the combination of power and exponential functions. Then, the evolutionary types of the interactive coercing relationship are divided into nine ones: rudimentary coordinating, ecology-dominated, synchronal coordinating, urbanization lagging, stepwise break-in, exorbitant urbanization, fragile ecology, rudimentary break-in and unsustainable types. Finally, based on an interactive coercion model, the degree of interactive coercion can be examined, and then, an evolutionary cycle can be divided into four phases, namely rudimentary symbiosis, harmonious development, utmost increasing and spiral type rising. The study results offer a scientific decision-making of healthy urbanization for achieving the goal of eco-environment protection and promoting urbanization.
基金supported by the Yunnan Fundamental Research Projects(Grant Nos.202401AU070163 and 202501AT070298)the Yunnan Engineering Research Center Innovation Ability Construction and Enhancement Projects(Grant No.2023-XMDJ-00617107)+5 种基金the University Service Key Industry Project of Yunnan Province(Grant No.FWCY-ZD2024005)the Expert Workstation Support Project of Yunnan Province(Grant No.202405AF140069)the Scientific Research Foundation of Kunming University of Science and Technology(Grant No.20220122)the Analysis and Test Foundation of Kunming University of Science and Technology(Grant No.2023T20220122)the Natural Science Foundation of Inner Mongolia Autonomous Region of China(Grant No.2025QN02057)the Ordos City Strategic Pioneering Science and Technology Special Program for New Energy(Grant No.DC2400003365).
文摘Lithium metal batteries(LMBs)have been regarded as one of the most promising alternatives in the post-lithium battery era due to their high energy density,which meets the needs of light-weight electronic devices and long-range electric vehicles.However,technical barriers such as dendrite growth and poor Li plating/stripping reversibility severely hinder the practical application of LMBs.However,lithium nitrate(LiNO_(3))is found to be able to stabilize the Li/electrolyte interface and has been used to address the above challenges.To date,considerable research efforts have been devoted toward understanding the roles of LiNO_(3) in regulating the surface properties of Li anodes and toward the development of many effective strategies.These research efforts are partially mentioned in some articles on LMBs and yet have not been reviewed systematically.To fill this gap,we discuss the recent advances in fundamental and technological research on LiNO_(3) and its derivatives for improving the performances of LMBs,particularly for Li-sulfur(S),Li-oxygen(O),and Li-Li-containing transition-metal oxide(LTMO)batteries,as well as LiNO_(3)-containing recipes for precursors in battery materials and interphase fabrication.This review pays attention to the effects of LiNO_(3) in lithium-based batteries,aiming to provide scientific guidance for the optimization of electrode/electrolyte interfaces and enrich the design of advanced LMBs.
文摘The living circumstances of human beings are closely related to the geological environment. As exemplified by the Zhangjiakou-West Beijing region, this paper describes the intensive mantle-crust uplift, which led to anomalous element background values for regional rocks (ores) and soils. As a result, some agricultural crops, and forests and fruits are of “super-quality and high yield” or of “poor quality and low yield”. The anomalous elements can find their way into grains, fruits, vegetables and drinking water and then will be taken by human beings, constituting a food chain, which would directly impact human health and lead to the spread of some endemic diseases. Studies have shown that the geomorphological features in the Zhangjiakou-West Beijing region are the outcome of geotectonic evolution since the Mesozoic. Mantle-crust movement is the key factor leading to the evolution and change of the regionally geological environment.
基金supported by the Postgraduate Education Reform Project of Shandong Province(SDYAL2023032)the National Key Research and Development Program(2021YFB3500102)。
文摘Multidimensional confined structure systems are proposed and demonstrated by using MoO_(2)@MO_(2)C(MMC)to enhance the photothermal catalytic performance of the metal sulfides-multidimensional confined structure(TMs-MDCS).Specifically,the MMC nanoparticles confined to the surface of the ZnIn_(2)S_(4)hollow tube-shell(MMC/HT-ZIS)achieve a hydrogen evolution rate of 9.72 mmol g^(-1)h^(-1),which is 11.2 times higher than that of pure HT-ZIS.Meanwhile,the MnCdS(MCS)nanoparticles are encapsulated within the two-dimensional MMC(2D MMC/MCS)through precise regulation of size and morphology.The 10-MMC/MCS lamellar network demonstrates the highest hydrogen evolution rate of 8.19 mmol g^(-1)-h^(-1).The obtained MMC/TMs-MDCS catalysts exhibit an enhanced photocatalytic hydrogen evolution rate,which can be attributed to the strong synergistic interaction between the multidimensional confinement and the photothermal effects.The confinement space and the strong interfacial relationship within the MMC/TMs-MDCS create abundant channels and active sites that facilitate electron migration and transport.Furthermore,the construction of a confined environment positions these materials as promising candidates for achieving exceptional photothermal catalytic performance,as MMC/TMs-MDCS enhance light absorption through light scattering and reflecting effects.Additionally,the capacity of MMC/TMsMDCS to convert solar light into thermal energy significantly reduces the activation energy of the reaction,thereby facilitating reaction kinetics and accelerating the separation and transport of photogenerated carriers.This work provides valuable insights for the development of highly efficient photothermal catalytic water-splitting systems for hydrogen production using multidimensional confined catalysts.
文摘Agricultural intensification has led to an increase in monoculture and the use of chemical pesticides,resulting in a decline in biodiversity and a reduction in ecosystem services,particularly biological pest management.However,studies have shown that agroforestry can not only improve land productivity and biodiversity but also regulate some ecosystem services.This study reviews the impacts of physical and biological factors on herbivorous pests,parasites,and predatory natural enemies in fruit-crop agroforestry systems.Fruit-crop agroforestry systems provide high spatial heterogeneity by altering crop layouts,regulating the microclimate and soil quality,and offering food resources and shelter for natural enemies,thus promoting biological pest control.This enhances biological control and makes the agrocomplex system an effective tool for sustainable agriculture.Our research shows that volatile plant substances attract or repel pests and natural enemies based on the characteristics of the insects themselves.When scientifically designed,fruit-crop agroforestry systems provide high spatial heterogeneity and favorable microclimatic conditions,which enhance biological pest control and make the agroforestry system an effective tool for sustainable agriculture.Our research shows that fruit-crop agroforestry systems can provide richer food resources and habitat,enhancing biological pest control and improving pest management.
基金supported by the National Natural Science Foundation of China(No.41473068)supported by China Postdoctoral Science Foundation(No.2022M722667)。
文摘Fertilization or atmospheric deposition of nitrogen(N)and phosphorus(P)to terrestrial ecosystems can alter soil N(P)availability and the nature of nutrient limitation for plant growth.Changing the allocation of leaf P fractions is potentially an adaptive strategy for plants to cope with soil N(P)availability and nutrient-limiting conditions.However,the impact of the interactions between imbalanced anthropogenic N and P inputs on the concentrations and allocation proportions of leaf P fractions in forest woody plants remains elusive.We conducted a metaanalysis of data about the concentrations and allocation proportions of leaf P fractions,specifically associated with individual and combined additions of N and P in evergreen forests,the dominant vegetation type in southern China where the primary productivity is usually considered limited by P.This assessment allowed us to quantitatively evaluate the effects of N and P additions alone and interactively on leaf P allocation and use strategies.Nitrogen addition(exacerbating P limitation)reduced the concentrations of leaf total P and different leaf P fractions.Nitrogen addition reduced the allocation to leaf metabolic P but increased the allocation to other fractions,while P addition showed opposite trends.The simultaneous additions of N and P showed an antagonistic(mutual suppression)effect on the concentrations of leaf P fractions,but an additive(summary)effect on the allocation proportions of leaf P fractions.These results highlight the importance of strategies of leaf P fraction allocation in forest plants under changes in environmental nutrient availability.Importantly,our study identified critical interactions associated with combined N and P inputs that affect leaf P fractions,thus aiding in predicting plant acclimation strategies in the context of intensifying and imbalanced anthropogenic nutrient inputs.
基金support from the National Key Research and Development Program of China(No.2022YFE0137400)the National Natural Science Foundation of China(Grant No.62274040).
文摘The past decade has witnessed the rapid increasement in power conversion efficiency of perovskite solar cells(PSCs).However,serious ion migration hampers their operational stability.Although dopants composed of varied cations and anions are introduced into perovskite to suppress ion migration,the impact of cations or anions is not individually explored,which hinders the evaluation of different cations and further application of doping strategy.Here we report that a special group of sulfonic anions(like CF_(3)SO_(3)^(-))successfully introduce alkaline earth ions(like Ca^(2+))into perovskite lattice compared to its halide counterparts.Furthermore,with effective crystallization regulation and defect passivation of sulfonic anions,perovskite with Ca(CF_(3)SO_(3))_(2)shows reduced PbI2 residue and metallic Pb0 defects;thereby,corresponding PSCs show an enhanced PCE of 24.95%.Finally by comparing the properties of perovskite with Ca(CF_(3)SO_(3))_(2)and FACF_(3)SO_(3),we found that doped Ca^(2+)significantly suppressed halide migration with an activation energy of 1.246 eV which accounts for the improved operational stability of Ca(CF_(3)SO_(3))_(2-)doped PSCs,while no obvious impact of Ca^(2+)on trap density is observed.Combining the benefits of cations and anions,this study presents an effective method to decouple the effects of cations and anions and fabricate efficient and stable PSCs.
文摘Objective The use of lasers has been an important part of urology in the treatment of stone and prostate disease.The thermal effects of lasers in lithotripsy have been a subject of debate over the years.The objective of this review was to assess the current state of knowledge available on the thermal effects of lasers in lithotripsy,as well as explore any new areas where studies are needed.Methods In August 2022,a keyword search on Google Scholar,PubMed,and Scopus for all papers containing the phrases“thermal effects”AND“laser”AND“lithotripsy”AND“urology”was done followed by citation jumping to other studies pertaining to the topic and 35 relevant papers were included in our study.The data from relevant papers were segregated into five groups according to the factor studied and type of study,and tables were created for a comparison of data.Results Temperature above the threshold of 43℃ was reached only when the power was>40 W and when there was adequate irrigation(at least 15–30 mL/min).Shorter lasing time divided by lithotripsy time or operator duty cycles less than 70%also resulted in a smaller temperature rise.Conclusion At least eight factors modify the thermal effects of lasers,and most importantly,the use of chilled irrigation at higher perfusion rates,lower power settings of<40 W,and with a shorter operator duty cycle will help to prevent thermal injuries from occurring.Stones impacted in the ureter or pelvi-ureteric junction further increase the probability of thermal injuries during laser firing.
基金Supported by the National Natural Science Foundation of China,No.82072537the General Project of Hunan Natural Science Foundation,No.2022JJ30412 and No.2021JJ30464.
文摘Exosomes(Exos)are extracellular vesicles secreted by cells and serve as crucial mediators of intercellular communication.They play a pivotal role in the pathogenesis and progression of various diseases and offer promising avenues for therapeutic interventions.Exos derived from mesenchymal stem cells(MSCs)have significant immunomodulatory properties.They effectively regulate immune responses by modulating both innate and adaptive immunity.These Exos can inhibit excessive inflammatory responses and promote tissue repair.Moreover,they participate in antigen presentation,which is essential for activating immune responses.The cargo of these Exos,including ligands,proteins,and microRNAs,can suppress T cell activity or enhance the population of immunosuppressive cells to dampen the immune response.By inhibiting lymphocyte proliferation,acting on macrophages,and increasing the population of regulatory T cells,these Exos contribute to maintaining immune and metabolic homeostasis.Furthermore,they can activate immune-related signaling pathways or serve as vehicles to deliver microRNAs and other bioactive substances to target tumor cells,which holds potential for immunotherapy applications.Given the immense therapeutic potential of MSC-derived Exos,this review comprehensively explores their mechanisms of immune regulation and therapeutic applications in areas such as infection control,tumor suppression,and autoimmune disease management.This article aims to provide valuable insights into the mechanisms behind the actions of MSC-derived Exos,offering theoretical references for their future clinical utilization as cell-free drug preparations.
文摘Excellent progress has been made in the last few decades in the cure rates of pediatric malignancies,with more than 80%of children with cancer who have access to contemporary treatment being cured.However,the therapies responsible for this survival can also produce adverse physical and psychological long-term outcomes,referred to as late effects,which appear months to years after the completion of cancer treatment.Research has shown that 60%to 90%of childhood cancer survivors(CCSs)develop one or more chronic health conditions,and 20%to 80%of survivors experience severe or life-threatening complications during adulthood.Therefore,understanding the late side effects of such treatments is important to improve the health and quality of life of the growing population of CCSs.
基金Supported by Science and Technology Innovation 2030-Major Projects,No.2021ZD0202000National Key Research and Development Program of China,No.2019YFA0706200+2 种基金National Natural Science Foundation of China,No.82371535Science and Technology Innovation Program of Hunan Province,No.2023RC3083Fundamental Research Funds for the Central Universities of Central South University,No.2023ZZTS0838.
文摘BACKGROUND Sensitivity to stress is essential in the onset,clinical symptoms,course,and prognosis of major depressive disorder(MDD).Meanwhile,it was unclear how variously classified but connected stress-sensitivity variables affect MDD.We hypothesize that high-level trait-and state-related stress-sensitivity factors may have different cumulative effects on the clinical symptoms and follow-up outcomes of MDD.AIM To investigate how stress-sensitivity factors added up and affected MDD clinical symptoms and follow-up results.METHODS In this prospective study,281 MDD patients were enrolled from a tertiary care setting.High-level stress-sensitivity factors were classified as trait anxiety,state anxiety,perceived stress,and neuroticism,with a total score in the top quartile of the research cohort.The cumulative effects of stress-sensitivity factors on cognitive dysfunction,disability and functional impairment,suicide risk,and depressive and anxiety symptoms were examined using an analysis of variance with linear trend analysis.Correlations were investigated further using multiple regression analysis.RESULTS Regarding high-level stress-sensitivity factors,53.40%of patients had at least one at baseline,and 29.61%had two or more.Four high-level stress-sensitivity components had significant cumulative impacts on MDD symptoms at baseline(all P<0.001).Perceived stress predicted the greatest effect sizes of state-related factors on depressive symptoms(partialη^(2)=0.153;standardizedβ=0.195;P<0.05).The follow-up outcomes were significantly impacted only by the high-level trait-related components,mainly when it came to depressive symptoms and suicide risk,which were predicted by trait anxiety and neuroticism,respectively(partialη^(2)=0.204 and 0.156;standardizedβ=0.247 and 0.392;P<0.05).CONCLUSION To enhance outcomes of MDD and lower the suicide risk,screening for stress-sensitivity factors and considering multifaceted measures,mainly focusing on trait-related ones,should be addressed clinically.
基金supported by the National Natural Science Foundation of China(No.22465009)the Education Department of Guizhou Province(No.2021312)the Foundation of Guizhou Province(No.2019-5666).
文摘Alloying and interface effects are effective strategies for enhancing the performance of electrocatalysts in energy-related devices.Herein,dendritic Au-doped platinum-palladium alloy/dumbbell-like bismuth telluride heterostructures(denoted PtPdAu/BiTe)were synthesized using a visible-light-assisted strategy.The coupling alloy and interfacial effects of PtPdAu/BiTe significantly improved the performance and stability of both the ethanol oxidation reaction(EOR)and methanol oxidation reaction(MOR).Introducing a small amount of Au effectively enhanced the CO tolerance of PtPdAu/BiTe compared to dendritic platinum-palladium alloy/dumbbell-like bismuth telluride heterostructures.PtPdAu/BiTe exhibited mass activities of 31.5 and 13.3 A·mg_(Pt)^(-1)in EOR and MOR,respectively,which were 34.4 and 13.2 times higher than those of commercial Pt black,revealing efficient Pt atom utilization.In-situ Fourier transform infrared spectroscopy demonstrated complete 12e^(-)and 6e^(-)oxidation of ethanol and methanol on PtPdAu/BiTe.The PtPdAu/BiTe/C achieved mass peak power densities of 131 and 156 mW·mg_(Pt)^(-1),which were 2.4 and 2.2 times higher than those of Pt/C in practical direct ethanol fuel cell(DEFC)and direct methanol fuel cell(DMFC),respectively,highlighting their potential application in DEFC and DMFC.This study introduces an effective strategy for designing efficient and highly CO tolerant anodic electrocatalysts for practical DEFC and DMFC applications.
