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Adeno-associated viral vectors for modeling Parkinson's disease in non-human primates
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作者 Julia Chocarro José L.Lanciego 《Neural Regeneration Research》 2026年第1期224-232,共9页
The development of clinical candidates that modify the natural progression of sporadic Parkinson's disease and related synucleinopathies is a praiseworthy endeavor,but extremely challenging.Therapeutic candidates ... The development of clinical candidates that modify the natural progression of sporadic Parkinson's disease and related synucleinopathies is a praiseworthy endeavor,but extremely challenging.Therapeutic candidates that were successful in preclinical Parkinson's disease animal models have repeatedly failed when tested in clinical trials.While these failures have many possible explanations,it is perhaps time to recognize that the problem lies with the animal models rather than the putative candidate.In other words,the lack of adequate animal models of Parkinson's disease currently represents the main barrier to preclinical identification of potential disease-modifying therapies likely to succeed in clinical trials.However,this barrier may be overcome by the recent introduction of novel generations of viral vectors coding for different forms of alpha-synuclein species and related genes.Although still facing several limitations,these models have managed to mimic the known neuropathological hallmarks of Parkinson's disease with unprecedented accuracy,delineating a more optimistic scenario for the near future. 展开更多
关键词 adeno-associated viral vectors ALPHA-SYNUCLeIN DOPAMINe Lewy bodies NeURODeGeNeRATION NeUROMeLANIN NeUROPATHOLOGY substantia nigra
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A Convolutional Neural Network-Based Deep Support Vector Machine for Parkinson’s Disease Detection with Small-Scale and Imbalanced Datasets
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作者 Kwok Tai Chui Varsha Arya +2 位作者 Brij B.Gupta Miguel Torres-Ruiz Razaz Waheeb Attar 《Computers, Materials & Continua》 2026年第1期1410-1432,共23页
Parkinson’s disease(PD)is a debilitating neurological disorder affecting over 10 million people worldwide.PD classification models using voice signals as input are common in the literature.It is believed that using d... Parkinson’s disease(PD)is a debilitating neurological disorder affecting over 10 million people worldwide.PD classification models using voice signals as input are common in the literature.It is believed that using deep learning algorithms further enhances performance;nevertheless,it is challenging due to the nature of small-scale and imbalanced PD datasets.This paper proposed a convolutional neural network-based deep support vector machine(CNN-DSVM)to automate the feature extraction process using CNN and extend the conventional SVM to a DSVM for better classification performance in small-scale PD datasets.A customized kernel function reduces the impact of biased classification towards the majority class(healthy candidates in our consideration).An improved generative adversarial network(IGAN)was designed to generate additional training data to enhance the model’s performance.For performance evaluation,the proposed algorithm achieves a sensitivity of 97.6%and a specificity of 97.3%.The performance comparison is evaluated from five perspectives,including comparisons with different data generation algorithms,feature extraction techniques,kernel functions,and existing works.Results reveal the effectiveness of the IGAN algorithm,which improves the sensitivity and specificity by 4.05%–4.72%and 4.96%–5.86%,respectively;and the effectiveness of the CNN-DSVM algorithm,which improves the sensitivity by 1.24%–57.4%and specificity by 1.04%–163%and reduces biased detection towards the majority class.The ablation experiments confirm the effectiveness of individual components.Two future research directions have also been suggested. 展开更多
关键词 Convolutional neural network data generation deep support vector machine feature extraction generative artificial intelligence imbalanced dataset medical diagnosis Parkinson’s disease small-scale dataset
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“5E”康复护理联合间歇导尿术在脊髓损伤神经源性膀胱患者中的应用
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作者 孔培培 翟清华 +2 位作者 张会 李树强 刘晓辉 《中国实用神经疾病杂志》 2026年第1期85-89,共5页
目的探讨“5E”康复护理联合间歇导尿术在脊髓损伤后神经源性膀胱患者中的应用效果。方法选取2022-03—2025-02郑州大学第二附属医院康复医学科2个病区收治的42例脊髓损伤后神经源性膀胱患者为研究对象,随机分为对照组和观察组,各21例... 目的探讨“5E”康复护理联合间歇导尿术在脊髓损伤后神经源性膀胱患者中的应用效果。方法选取2022-03—2025-02郑州大学第二附属医院康复医学科2个病区收治的42例脊髓损伤后神经源性膀胱患者为研究对象,随机分为对照组和观察组,各21例。对照组实施间歇导尿术和常规护理,观察组在间歇导尿术和常规护理基础上联合“5E”康复护理干预。干预4周后,比较2组最大膀胱安全容量、排尿期最大膀胱内压、残余尿量、尿道括约肌功能、汉密尔顿焦虑量表(HAMA)评分及世界卫生组织生活质量简表(WHOQOL-BREF)评分,记录并发症发生情况。结果干预后,观察组与对照组最大膀胱安全容量、排尿期最大膀胱内压、残余尿量比较,差异均有统计学意义(P<0.05)。干预后,观察组与对照组尿道括约肌松弛患者及尿道括约肌痉挛或失协调患者排尿期最大尿道压力比较,差异均有统计学意义(P<0.05)。干预后,观察组与对照组HAMA评分、WHOQOL-BREF评分比较,差异均有统计学意义(P<0.05)。结论“5E”康复护理协同间歇导尿术管理神经源性膀胱,可改善脊髓损伤患者的排尿功能及尿道括约肌功能,改善负面情绪和生活质量。 展开更多
关键词 脊髓损伤 神经源性膀胱 “5e”康复护理 间歇导尿术 排尿功能 负面情绪 尿路感染
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基于Nrf2/ARE信号通路探讨中药山茱萸鞣质改善阿尔茨海默病小鼠认知障碍的作用机制
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作者 陈鹏 陈小青 +3 位作者 黎昌林 甘雄 刘刚 周本宏 《环球中医药》 2026年第1期18-26,共9页
目的探讨中药山茱萸鞣质对D-半乳糖(D-Galactose,D-gal)致阿尔茨海默病(Alzheimer爷s disease,AD)小鼠认知障碍的保护作用及药理机制。方法选取60只C57小鼠随机分为空白对照组、D-gal模型组、阳性对照组(维生素E 150 mg/kg)及山茱萸鞣... 目的探讨中药山茱萸鞣质对D-半乳糖(D-Galactose,D-gal)致阿尔茨海默病(Alzheimer爷s disease,AD)小鼠认知障碍的保护作用及药理机制。方法选取60只C57小鼠随机分为空白对照组、D-gal模型组、阳性对照组(维生素E 150 mg/kg)及山茱萸鞣质高、中、低(150、100、50 mg/kg)剂量组,每组10只。利用D-gal腹腔注射诱导AD小鼠模型,同时每天给予相应剂量的药物进行灌胃干预,实验周期维持8周。末次灌胃给药结束后,利用Morris水迷宫和旷场实验评估小鼠学习记忆与认知功能,使用分光光度法检测海马组织超氧化物歧化酶(superoxide dismutase,SOD)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)、过氧化氢酶(catalase,CAT)抗氧化酶活力及丙二醛(malondialdehyde,MDA)含量,采用苏木精—伊红染色和Nissl染色观察海马区病理变化,并运用蛋白印迹法(Western blot,WB)考察突触相关蛋白微管关联蛋白-2(microtubule-associatedprotein-2,MAP-2)、突触后密度蛋白-95(postsynaptic density protein-95,PSD-95)、突触素(synaptophysin,SYN)及核因子E2相关因子2/抗氧化反应元件(nuclear factor E2-related factor 2/an-tioxidant response element,Nrf2/ARE)抗氧化信号通路相关蛋白Nrf2、血红素氧合酶-1(hemeoxygenase-1,HO-1)、醌氧化还原酶1(quinone oxidoreductase 1,NQO1)等表达变化水平。结果与D-gal模型组比较,山茱萸鞣质给药组小鼠在Morris水迷宫实验中的逃避潜伏期显著降低、目标区域停留时间和穿越平台次数显著增加(P<0.01);在旷场实验中的跨格次数、中心区域停留时间、平均速度及总路程均明显增加(P<0.01)。生化结果显示,与D-gal模型组比较,山茱萸鞣质给药组小鼠脑内SOD、GSH-Px及CAT等抗氧化酶活力显著上升(P<0.01),MDA含量明显下降(P<0.01)。苏木精—伊红染色与Nissl染色结果表明,与D-gal模型组比较,山茱萸鞣质给药组小鼠神经元受损情况明显减轻。Western blot结果显示,与D-gal模型组相比,山茱萸鞣质给药组小鼠脑内MAP-2、PSD-95、SYN、HO-1、NQO1、Nrf2等蛋白表达水平均显著增加(P<0.01)。结论山茱萸鞣质可改善D-gal致AD小鼠的认知障碍和神经元突触损伤,其潜在分子机制可能与上调Nrf2/ARE信号通路并减轻海马组织氧化应激有关。 展开更多
关键词 山茱萸鞣质 阿尔茨海默病 认知障碍 氧化应激 核因子e2相关因子2/抗氧化反应元件通路
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Joint Estimation of SOH and RUL for Lithium-Ion Batteries Based on Improved Twin Support Vector Machineh 被引量:1
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作者 Liyao Yang Hongyan Ma +1 位作者 Yingda Zhang Wei He 《Energy Engineering》 EI 2025年第1期243-264,共22页
Accurately estimating the State of Health(SOH)and Remaining Useful Life(RUL)of lithium-ion batteries(LIBs)is crucial for the continuous and stable operation of battery management systems.However,due to the complex int... Accurately estimating the State of Health(SOH)and Remaining Useful Life(RUL)of lithium-ion batteries(LIBs)is crucial for the continuous and stable operation of battery management systems.However,due to the complex internal chemical systems of LIBs and the nonlinear degradation of their performance,direct measurement of SOH and RUL is challenging.To address these issues,the Twin Support Vector Machine(TWSVM)method is proposed to predict SOH and RUL.Initially,the constant current charging time of the lithium battery is extracted as a health indicator(HI),decomposed using Variational Modal Decomposition(VMD),and feature correlations are computed using Importance of Random Forest Features(RF)to maximize the extraction of critical factors influencing battery performance degradation.Furthermore,to enhance the global search capability of the Convolution Optimization Algorithm(COA),improvements are made using Good Point Set theory and the Differential Evolution method.The Improved Convolution Optimization Algorithm(ICOA)is employed to optimize TWSVM parameters for constructing SOH and RUL prediction models.Finally,the proposed models are validated using NASA and CALCE lithium-ion battery datasets.Experimental results demonstrate that the proposed models achieve an RMSE not exceeding 0.007 and an MAPE not exceeding 0.0082 for SOH and RUL prediction,with a relative error in RUL prediction within the range of[-1.8%,2%].Compared to other models,the proposed model not only exhibits superior fitting capability but also demonstrates robust performance. 展开更多
关键词 State of health remaining useful life variational modal decomposition random forest twin support vector machine convolutional optimization algorithm
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Thrust-vectoring schemes for electric propulsion systems:A review 被引量:1
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作者 Andrei SHUMEIKO Victor TELEKH Sergei RYZHKOV 《Chinese Journal of Aeronautics》 2025年第6期179-203,共25页
Thrust-vectoring capability has become a critical feature for propulsion systems as space missions move from static to dynamic.Thrust-vectoring is a well-developed area of rocket engine science.For electric propulsion... Thrust-vectoring capability has become a critical feature for propulsion systems as space missions move from static to dynamic.Thrust-vectoring is a well-developed area of rocket engine science.For electric propulsion,however,it is an evolving field that has taken a new leap forward in recent years.A review and analysis of thrust-vectoring schemes for electric propulsion systems have been conducted.The scope of this review includes thrust-vectoring schemes that can be implemented for electrostatic,electromagnetic,and beam-driven thrusters.A classification of electric propulsion schemes that provide thrust-vectoring capability is developed.More attention is given to schemes implemented in laboratory prototypes and flight models.The final part is devoted to a discussion on the suitability of different electric propulsion systems with thrust-vectoring capability for modern space mission operations.The thrust-vectoring capability of electric propulsion is necessary for inner and outer space satellites,which are at a disadvantage with conventional unidirectional propulsion systems due to their limited maneuverability. 展开更多
关键词 electric propulsion Spacecraft propulsion Plasma sources Flight control systems Thrust vectoring Thrust vector control
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肝移植术中RhE抗原匹配输血对患者早期预后的影响分析
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作者 于晓超 高鑫源 +7 位作者 海帆 杨超 侯星羽 邢亚萍 高红强 张鸿伟 苏纲 徐荣华 《中国输血杂志》 2026年第1期44-50,68,共8页
目的探讨肝移植术RhE抗原匹配输血对患者术后早期恢复及并发症的影响。方法采用回顾性队列研究设计,选择2022年1月至2025年7月在昆明市第一人民医院接受肝移植手术的95例患者为研究对象。将患者分为2组:RHE不匹配输血组(n=57)和RHE匹配... 目的探讨肝移植术RhE抗原匹配输血对患者术后早期恢复及并发症的影响。方法采用回顾性队列研究设计,选择2022年1月至2025年7月在昆明市第一人民医院接受肝移植手术的95例患者为研究对象。将患者分为2组:RHE不匹配输血组(n=57)和RHE匹配输血组(n=38),比较2组患者基线资料、术后d1、d3、d5、d7、d10的血常规、肝肾功能、凝血功能及并发症发生率。采用KAPLAN-MEIER法进行生存分析。结果2组患者基线资料均衡可比(均P>0.05)。不匹配组术后早期死亡率(31.58%,18/57)高于匹配组(10.53%,4/38),差异具有统计学意义(P=0.017)。不匹配组术后肝性脑病发病率(50.88%,29/57)高于匹配组(10.53%,4/38),差异具有统计学意义(P<0.001)。不匹配组术后出血发生率(24.56%,14/57)高于匹配组(5.26%,2/38),差异具有统计学意义(P=0.014)。不匹配组围术期感染发生率(28.07%,16/57)高于匹配组(10.53%,4/38),差异具有统计学意义(P=0.04)。对应的OR值及95%置信区间提示匹配组上述不良事件发生风险更低。术后D1,不匹配组活化部分凝血酶时间变化量(-1.6,20.5)高于匹配组(-0.2,5.5),不匹配组国际标准化比值变化量(-0.56,1.22)高于匹配组(-0.18,0.32),不匹配组白蛋白变化量(-4,4.8)低于匹配组(-2.5,8.8)。术后d5,不匹配组白蛋白变化量(-0.41±7.83)低于匹配组(2.68±4.53)。术后d7,不匹配组白蛋白变化量(-0.61±7.38)低于匹配组(2.51±5.85),不匹配组D-二聚体变化量(0.73,7.4)高于匹配组(-1.6,4.3)。术后D10,不匹配组纤维蛋白原(-1.21,1.78)高于匹配组(-0.49,0.97),不匹配组凝血酶原时间(-11.3,-2.7)高于匹配组(-6.2,-0.8),具有统计学意义(均P<0.05)。匹配组OS均值为32.803个月(95%CI:29.171~36.436),显著高于不匹配组的28.996个月(95%CI:24.202~33.790),LOG-RANK检验结果具有统计学意义(χ^(2)=4.307,P=0.038)。结论在肝移植术中实施RhE抗原匹配输血,可能有助于降低患者术后早期死亡率和主要并发症发生率,促进凝血功能与肝功能更快恢复,改善患者短期预后。 展开更多
关键词 RH血型 e抗原 输血 肝功能
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Evaluating vector winds over eastern China in 2022 predicted by the CMA-MESO model and ECMWF forecast 被引量:1
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作者 Fang Huang Mingjian Zeng +4 位作者 Zhongfeng Xu Boni Wang Ming Sun Hangcheng Ge Shoukang Wu 《Atmospheric and Oceanic Science Letters》 2025年第4期41-47,共7页
Vector winds play a crucial role in weather and climate,as well as the effective utilization of wind energy resources.However,limited research has been conducted on treating the wind field as a vector field in the eva... Vector winds play a crucial role in weather and climate,as well as the effective utilization of wind energy resources.However,limited research has been conducted on treating the wind field as a vector field in the evaluation of numerical weather prediction models.In this study,the authors treat vector winds as a whole by employing a vector field evaluation method,and evaluate the mesoscale model of the China Meteorological Administration(CMA-MESO)and ECMWF forecast,with reference to ERA5 reanalysis,in terms of multiple aspects of vector winds over eastern China in 2022.The results show that the ECMWF forecast is superior to CMA-MESO in predicting the spatial distribution and intensity of 10-m vector winds.Both models overestimate the wind speed in East China,and CMA-MESO overestimates the wind speed to a greater extent.The forecasting skill of the vector wind field in both models decreases with increasing lead time.The forecasting skill of CMA-MESO fluctuates more and decreases faster than that of the ECMWF forecast.There is a significant negative correlation between the model vector wind forecasting skill and terrain height.This study provides a scientific evaluation of the local application of vector wind forecasts of the CMA-MESO model and ECMWF forecast. 展开更多
关键词 Model evaluation vector winds CMA-MeSO eCMWF Forecasting skill
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A Support Vector Machine(SVM)Model for Privacy Recommending Data Processing Model(PRDPM)in Internet of Vehicles
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作者 Ali Alqarni 《Computers, Materials & Continua》 SCIE EI 2025年第1期389-406,共18页
Open networks and heterogeneous services in the Internet of Vehicles(IoV)can lead to security and privacy challenges.One key requirement for such systems is the preservation of user privacy,ensuring a seamless experie... Open networks and heterogeneous services in the Internet of Vehicles(IoV)can lead to security and privacy challenges.One key requirement for such systems is the preservation of user privacy,ensuring a seamless experience in driving,navigation,and communication.These privacy needs are influenced by various factors,such as data collected at different intervals,trip durations,and user interactions.To address this,the paper proposes a Support Vector Machine(SVM)model designed to process large amounts of aggregated data and recommend privacy preserving measures.The model analyzes data based on user demands and interactions with service providers or neighboring infrastructure.It aims to minimize privacy risks while ensuring service continuity and sustainability.The SVMmodel helps validate the system’s reliability by creating a hyperplane that distinguishes between maximum and minimum privacy recommendations.The results demonstrate the effectiveness of the proposed SVM model in enhancing both privacy and service performance. 展开更多
关键词 Support vector machine big data IoV PRIVACY-PReSeRVING
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Comprehensive analysis of noise in Macao Science Satellite-1 vector magnetometer data 被引量:1
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作者 SiShan Song Fan Yin +4 位作者 Qin Yan Hermann Lühr Chao Xiong Yi Jiang PengFei Liu 《Earth and Planetary Physics》 2025年第3期532-540,共9页
The Macao Science Satellite-1(known as MSS-1)is the first scientific exploration satellite that was designed to measure the Earth's low latitude magnetic field at high resolution and with high precision by collect... The Macao Science Satellite-1(known as MSS-1)is the first scientific exploration satellite that was designed to measure the Earth's low latitude magnetic field at high resolution and with high precision by collecting data in a near-equatorial orbit.Magnetic field data from MSS-1's onboard Vector Fluxgate Magnetometer(VFM),collected at a sample rate of 50 Hz,allows us to detect and investigate sources of magnetic data contamination,from DC to relevant Nyquist frequency.Here we report two types of artificial disturbances in the VFM data.One is V-shaped events concentrated at night,with frequencies sweeping from the Nyquist frequency down to zero and back up.The other is 5-Hz events(ones that exhibit a distinct 5 Hz spectrum peak);these events are always accompanied by intervals of spiky signals,and are clearly related to the attitude control of the satellite.Our analyses show that VFM noise levels in daytime are systematically lower than in nighttime.The daily average noise levels exhibit a period of about 52 days.The V-shaped events are strongly correlated with higher VFM noise levels. 展开更多
关键词 Macao Science Satellite-1 vector Fluxgate Magnetometer artificial disturbances noise features
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A Survey on the Existence of Harmonic Metrics on Vector Bundles
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作者 SHEN Zhenghan ZHANG Xi 《数学进展》 北大核心 2025年第2期390-404,共15页
In this paper,we give a survey on the existence of Hermitian-Einstein metrics and harmonic metrics.
关键词 Hermitian-einstein metric harmonic metric holomorphic vector bundle non-Hermitian Yang-Mills bundle
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脐针联合维生素E、促排卵药物治疗多囊卵巢综合征不孕症的疗效及对氧化应激指标的影响
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作者 曾小连 阙彬福 +1 位作者 陈绍菲 林久茂 《中国现代药物应用》 2026年第3期32-36,共5页
目的探究脐针联合维生素E、促排卵药物对多囊卵巢综合征不孕症患者的治疗效果,以及对氧化应激指标的影响。方法140例多囊卵巢综合征不孕症患者,随机分为试验组与对照组,各70例。试验组患者使用脐针联合维生素E、促排卵药物治疗,对照组... 目的探究脐针联合维生素E、促排卵药物对多囊卵巢综合征不孕症患者的治疗效果,以及对氧化应激指标的影响。方法140例多囊卵巢综合征不孕症患者,随机分为试验组与对照组,各70例。试验组患者使用脐针联合维生素E、促排卵药物治疗,对照组患者单纯使用维生素E、促排卵药物治疗。对比两组排卵后1周孕酮(P)水平与超声指标,治疗效果,氧化应激指标[超氧化物歧化酶(SOD)、谷胱甘肽还原酶(GSH)、卵泡刺激素(FSH)]。结果试验组排卵后1周P水平(1.58±0.31)nmol/L高于对照组的(1.36±0.24)nmol/L,优势卵泡大小(20.25±2.22)mm、子宫内膜厚度(9.58±0.42)mm大于对照组的(17.53±2.25)、(8.36±0.21)mm,成熟卵泡数量(1.64±0.36)个多于对照组的(1.08±0.21)个(P<0.05)。试验组治疗总有效率100.00%高于对照组的92.86%(P<0.05)。治疗后,试验组SOD(200.52±12.51)U/ml、GSH(48.63±3.33)U/L、FSH(6.32±0.15)mIU/ml高于对照组的(186.46±12.33)U/ml、(42.16±3.24)U/L、(5.42±0.28)mIU/ml(P<0.05)。结论脐针联合维生素E、促排卵药物对多囊卵巢综合征不孕症患者进行治疗,能促进患者排卵后1周孕激素水平的恢复,同时促进优势卵泡大小、成熟卵泡生长及子宫内膜厚度的恢复,可实现理想治疗效果,达到对氧化应激状况的改善管理作用,可广泛应用于临床治疗中。 展开更多
关键词 脐针 维生素e 促排卵药物 多囊卵巢综合征 不孕症
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基于e值的r阶向上向下检验过程
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作者 邹文豪 杨建萍 《山东理工大学学报(自然科学版)》 2026年第3期59-66,71,共9页
为解决传统的p值多重检验过程在不规则模型下计算困难问题,在e-BH过程的基础上,提出了基于e值的r阶向上向下检验过程,以进一步提高多重检验过程的检测能力。理论研究该检验过程性能发现,对满足任意相关性条件的e值检验统计量都能将假发... 为解决传统的p值多重检验过程在不规则模型下计算困难问题,在e-BH过程的基础上,提出了基于e值的r阶向上向下检验过程,以进一步提高多重检验过程的检测能力。理论研究该检验过程性能发现,对满足任意相关性条件的e值检验统计量都能将假发现率(False Discovery Rate,FDR)控制到指定水平,同时该过程具有无偏性。使用与FDR、假阴率(False Negatives Rate,FNR)相关的指标,通过模拟实验将基于e值的r阶向上向下检验过程与e-BH过程、传统的p值多重检验过程进行比较,发现该检验过程具有更强的检测能力,完全可以替代传统的p值多重检验过程。 展开更多
关键词 多重假设检验 假发现率 假阴率 e 无偏性
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A VECTOR BUNDLE VALUED MIXED HARD LEFSCHETZ THEOREM
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作者 Zeng CHEN Guanxiang WANG 《Acta Mathematica Scientia》 2025年第2期514-524,共11页
In this paper,we obtain a vector bundle valued mixed hard Lefschetz theorem.The argument is mainly based on the works of Tien-Cuong Dinh and Viet-Anh Nguyen.
关键词 hard Lefschetz theorem holomorphic vector bundle Hermitian fat vector bundle
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Insecticide resistance status of malaria vectors in endemic states of India(2017-2024):A scoping review
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作者 Kamaraju Raghavendra Poonam Sharma Velamuri +1 位作者 Vartika Singhal Roop Kumari 《Asian Pacific Journal of Tropical Medicine》 2025年第8期337-352,I0003-I0013,共27页
Objective:To collate and summarize phenotypic insecticide susceptibility data of Indian malaria vectors from 2017 to 2024,focusing on insecticides used in adult vector control,dichloro diphenyl trichloroethane,malathi... Objective:To collate and summarize phenotypic insecticide susceptibility data of Indian malaria vectors from 2017 to 2024,focusing on insecticides used in adult vector control,dichloro diphenyl trichloroethane,malathion,deltamethrin,alpha-cypermethrin,and permethrin to identify resistance patterns to different classes of insecticides.Methods:The data included information on vector species,location of the study(state/district),insecticide tested,mortality percentage,and susceptibility classification based on the World Health Organization interpretation criteria.Retrospective data were collected from peer-reviewed publications(2017-2024)and up to June 2025.The data were collated for five major malaria vector species,namely Anopheles(An.)culicifacies,An.fluviatilis,An.stephensi,An.baimaii,and An.minimus.Results:Insecticide susceptibility data were available from 86 districts across 16 Indian states for 40615 mosquitoes.The majority of the data was on An.culicifacies(n=28308),followed by An.stephensi(n=5611),An.fluviatilis(n=5967),An.baimaii(n=365),and An.minimus(n=364).Intensity bioassays revealed low to moderate resistance levels in An.culicifacies populations from selected districts in 3 states,Odisha,Madhya Pradesh,and Chhattisgarh against deltamethrin and alpha-cypermethrin.Conclusions:This review highlights spatial and species-level variations in insecticide susceptibility among Indian malaria vectors.The low to moderate intensity suggested that it may not yet be severe enough to cause operational failure with current vector control interventions.Continued monitoring of insecticide resistance,as well as the use of new-generation insecticides and interventions,is suggested to sustain vector control efficacy and manage insecticide resistance in malaria vectors to support India’s malaria elimination. 展开更多
关键词 Malaria vectors Insecticide resistance INDIA
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COMMUTATOR ESTIMATES FOR VECTOR FIELDS ON BESOV SPACES WITH VARIABLE SMOOTHNESS AND INTEGRABILITY
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作者 BenMahmoud SALAH 《Acta Mathematica Scientia》 2025年第3期771-788,共18页
In this paper we present certain bilinear estimates for commutators on Besov spaces with variable smoothness and integrability,and under no vanishing assumptions on the divergence of vector fields.Such commutator esti... In this paper we present certain bilinear estimates for commutators on Besov spaces with variable smoothness and integrability,and under no vanishing assumptions on the divergence of vector fields.Such commutator estimates are motivated by the study of well-posedness results for some models in incompressible fuid mechanics. 展开更多
关键词 COMMUTATOR vector fields Besov space variable exponent
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A novel vector magnetic measurement system calibration method based on geomagnetic variation
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作者 Ji-hao Liu Xi-hai Li +2 位作者 Chao Niu Xiao-niu Zeng Yun Zhang 《Applied Geophysics》 2025年第1期35-42,232,共9页
Vector magnetic measurement is increasingly widely used.In order to improve the accuracy of vector magnetic measurement system on board a vehicle,researchers have proposed various calibration methods.Most of them requ... Vector magnetic measurement is increasingly widely used.In order to improve the accuracy of vector magnetic measurement system on board a vehicle,researchers have proposed various calibration methods.Most of them require altering the magnetic vector in the vehicle coordinate system.Exploring the use of geomagnetic variation to change the geomagnetic vector in the vehicle coordinate system,this paper proposes a novel vector magnetic measurement calibration method.In this method,a vector magnetometer mounted on a vehicle and an accurate vector magnetometer separately measure the geomagnetic field at diff erent locations within the same area.Based on the physical principle that the geomagnetic variation at two nearby locations is equal,the calibration parameters of the magnetometer on the vehicle can be determined through a set of equations containing the measurements from the two magnetometers.The theoretical derivation and simulation experiment results demonstrate the feasibility of this method.Therefore,it can serve as a new alternative calibration method,especially in scenarios where a high degree of accuracy in the estimation of calibration parameters is not required. 展开更多
关键词 vector magnetic measurement CALIBRATION geomagnetic variation
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A trace formula for the vector Sturm-Liouville operator with a constant delay
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作者 LI Dan YANG Chuan-fu 《Applied Mathematics(A Journal of Chinese Universities)》 2025年第1期213-222,共10页
In this work,the vector differential operator with a delay variable is studied and the regularized trace formula of the operator is obtained.
关键词 vector differential operator constant delay TRACe
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Efficient rock joint detection from large-scale 3D point clouds using vectorization and parallel computing approaches
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作者 Yunfeng Ge Zihao Li +2 位作者 Huiming Tang Qian Chen Zhongxu Wen 《Geoscience Frontiers》 2025年第5期1-15,共15页
The application of three-dimensional(3D)point cloud parametric analyses on exposed rock surfaces,enabled by Light Detection and Ranging(LiDAR)technology,has gained significant popularity due to its efficiency and the ... The application of three-dimensional(3D)point cloud parametric analyses on exposed rock surfaces,enabled by Light Detection and Ranging(LiDAR)technology,has gained significant popularity due to its efficiency and the high quality of data it provides.However,as research extends to address more regional and complex geological challenges,the demand for algorithms that are both robust and highly efficient in processing large datasets continues to grow.This study proposes an advanced rock joint identification algorithm leveraging artificial neural networks(ANNs),incorporating parallel computing and vectorization of high-performance computing.The algorithm utilizes point cloud attributes—specifically point normal and point curvatures-as input parameters for ANNs,which classify data into rock joints and non-rock joints.Subsequently,individual rock joints are extracted using the density-based spatial clustering of applications with noise(DBSCAN)technique.Principal component analysis(PCA)is subsequently employed to calculate their orientations.By fully utilizing the computational power of parallel computing and vectorization,the algorithm increases the running speed by 3–4 times,enabling the processing of large-scale datasets within seconds.This breakthrough maximizes computational efficiency while maintaining high accuracy(compared with manual measurement,the deviation of the automatic measurement is within 2°),making it an effective solution for large-scale rock joint detection challenges.©2025 China University of Geosciences(Beijing)and Peking University. 展开更多
关键词 Rock joints Pointclouds Artificialneuralnetwork High-performance computing Parallel computing vectorIZATION
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Cloning and Expression Vector Construction of BnZAT12 in Brassica napus
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作者 HUANG Xin ZHOU Li-hua +3 位作者 YUAN Yu-hui ZHONG Kai CHEN Dong-long LIU Xian-jun 《Agricultural Science & Technology》 2025年第1期45-54,共10页
To investigate the function of the zinc finger protein BnZAT12 in Brassica napus,bioinformatics analysis was conducted on BnZAT12.The results showed that the open reading frame of BnZAT12 was 477 bp in length,encoding... To investigate the function of the zinc finger protein BnZAT12 in Brassica napus,bioinformatics analysis was conducted on BnZAT12.The results showed that the open reading frame of BnZAT12 was 477 bp in length,encoding 158 amino acid residues.The deduced protein had a molecular weight of 16864.72 Da and a theoretical isoelectric point of 9.68.The phylogenetic tree showed that Brassica napus had the closest relationship with Brassica oleracea belonging to Brassicaceae and the farthest relationship with Oryza sativa.The analysis of the promoter region suggested that BnZAT12 may be regulated by factors such as light,abscisic acid,and methyl jasmonate.Furthermore,the BnZAT12 overexpression vector was constructed by seamless cloning.This study laid a foundation of molecular biology for further elucidating the role of BnZAT12. 展开更多
关键词 BnZAT12 Brassica napus Bioinformatics analysis vector construction
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