Bubble size distribution is the basic apparent performance and obvious characteristics in the air dense medium fluidized bed (ADMFB). The approaches of numerical simulation and experimental verification were combined ...Bubble size distribution is the basic apparent performance and obvious characteristics in the air dense medium fluidized bed (ADMFB). The approaches of numerical simulation and experimental verification were combined to conduct the further research on the bubble generation and movement behavior. The results show that ADMFB could display favorable expanded characteristics after steady fluidization. With different particle size distributions of magnetite powder as medium solids, we selected an appropriate prediction model for the mean bubble diameter in ADMFB. The comparison results indicate that the mean bubble diameters along the bed heights are 35 mm < D b < 66 mm and 40 mm < D b < 69 mm with the magnetite powder of 0.3 mm+0.15mm and 0.15mm+0.074mm, respectively. The prediction model provides good agreements with the experimental and simulation data. Based on the optimal operating gas velocity distribution, the mixture of magnetite powder and <1mm fine coal as medium solids were utilized to carry out the separation experiment on 6-50mm raw coal. The results show that an optimal separation density d P of 1.73g/cm 3 with a probable error E of 0.07g/cm 3 and a recovery efficiency of 99.97% is achieved, which indicates good separation performance by applying ADMFB.展开更多
The rapid diffusion of nanoparticles （NPs） through mucus layer is critical for efficient transportation of NPs-loaded drug delivery system. To understand how the physical and surface properties of NPs affect their d...The rapid diffusion of nanoparticles （NPs） through mucus layer is critical for efficient transportation of NPs-loaded drug delivery system. To understand how the physical and surface properties of NPs affect their diffusion in mucus, we have developed a coarse-grained molecular dynamics model to study the diffusion of NPs in modeled mucus layer. Both steric obstruction and hydrodynamic interaction are included in the model capable of capturing the key characteristics of NPs＇ diffusion in mucus. The results show that both particle size and surface properties significantly affect the diffusivities of NPs in mucus. Furthermore, we find rodlike NPs can gain a higher diffusivity than spherical NPs with the same hydrodynamic diameter. In addition, the disturbed environment can enhance the diffusivity of NPs. Our findings can be utilized to design mucus penetrating NPs for targeted drug delivery system.展开更多
Tailings impoundments can potentially collapse due to damage caused by earthquakes,which has frequently occurred around the world.This study takes the proposed valley type tailings impoundment in Yunnan as the researc...Tailings impoundments can potentially collapse due to damage caused by earthquakes,which has frequently occurred around the world.This study takes the proposed valley type tailings impoundment in Yunnan as the research object to analyze the dynamic response behavior under earthquake action with both numerical simulation and physical model test(1:300).The results of both tests show that the dynamic response of the valley type tailings impoundment is characterized by"medium stiffness effect",in other words,in a certain range,the"softer"the unsaturated tailings sand is,the more energy it can dissipate,which leads the decrease of the value of the acceleration amplification factor.In addition,the peak acceleration of the monitoring points increases with the vertical elevation,which indicates that the"elevation amplification effect"exists in the tailings impoundment dynamic response.The middle part of the outer side of the raised embankment reacts more sensitive than the crest,which is similar to the slope dynamic response.The starter dam reacts sensitively under the earthquake excitation,which should be given more attention during the seismic design.The dynamic response rules reflected by the numerical simulation are consistent with the results monitored on the physical model test,although there are some differences between their values.The dynamic response rules of the valley type tailings impoundment can provide basis for the design of the similar projects in this region.展开更多
The dynamic interaction problems of three-dimensional lineqr elastic structures with arbitrary shaped section embedded in a homogeneous, isotropic and linear elastic half space under dynamic disturbances are numerical...The dynamic interaction problems of three-dimensional lineqr elastic structures with arbitrary shaped section embedded in a homogeneous, isotropic and linear elastic half space under dynamic disturbances are numerically solved. The numerical method employed is a combination of the time domain semi-analytical boundary element method (SBEM) used for the semi-infinite soil medium and the semi-analytical finite element method (SFEM) used for the three-dimensional structure. The two methods are combined through equilibrium and compatibility conditions at the soil-structure interface. Displacements, velocities, accelerations and interaction forces at the interface between underground structure and soil medium produced by the diffraction of wave by an underground structure for every time step are obtained. In dynamic soil-structure interaction problems, it is advantageous to combine the SBEM and the SFEM in an effort to produce an optimum numerical hybrid scheme which is characterized by the main advantages of the two methods. The effects of the thickness, the ratio of length and diameter of underground structure and the soil medium on dynamic responses are discussed.展开更多
基金financially supported by the National Natural Science Foundation of China (Nos. 51221462, 51134022,51174203 and 51074156)the National Basic Research Program of China (No. 2012CB214904)China Postdoctoral Science Foundation (No. 2013M531430)
文摘Bubble size distribution is the basic apparent performance and obvious characteristics in the air dense medium fluidized bed (ADMFB). The approaches of numerical simulation and experimental verification were combined to conduct the further research on the bubble generation and movement behavior. The results show that ADMFB could display favorable expanded characteristics after steady fluidization. With different particle size distributions of magnetite powder as medium solids, we selected an appropriate prediction model for the mean bubble diameter in ADMFB. The comparison results indicate that the mean bubble diameters along the bed heights are 35 mm < D b < 66 mm and 40 mm < D b < 69 mm with the magnetite powder of 0.3 mm+0.15mm and 0.15mm+0.074mm, respectively. The prediction model provides good agreements with the experimental and simulation data. Based on the optimal operating gas velocity distribution, the mixture of magnetite powder and <1mm fine coal as medium solids were utilized to carry out the separation experiment on 6-50mm raw coal. The results show that an optimal separation density d P of 1.73g/cm 3 with a probable error E of 0.07g/cm 3 and a recovery efficiency of 99.97% is achieved, which indicates good separation performance by applying ADMFB.
基金the financial support from the National Natural Science Foundation of China (No. 11422215, 11272327 and 11672079)supported by the Supercomputing Center of Chinese Academy of Sciences (SC CAS)
文摘The rapid diffusion of nanoparticles （NPs） through mucus layer is critical for efficient transportation of NPs-loaded drug delivery system. To understand how the physical and surface properties of NPs affect their diffusion in mucus, we have developed a coarse-grained molecular dynamics model to study the diffusion of NPs in modeled mucus layer. Both steric obstruction and hydrodynamic interaction are included in the model capable of capturing the key characteristics of NPs＇ diffusion in mucus. The results show that both particle size and surface properties significantly affect the diffusivities of NPs in mucus. Furthermore, we find rodlike NPs can gain a higher diffusivity than spherical NPs with the same hydrodynamic diameter. In addition, the disturbed environment can enhance the diffusivity of NPs. Our findings can be utilized to design mucus penetrating NPs for targeted drug delivery system.
基金financially supported by project (Grant NO. U1502232, U1033601)-National Science Foundation of China-Yunnan Joint Fundproject (Grant NO. 20135314110005)-Research Fund for the Doctoral Program of Higher Education of China
文摘Tailings impoundments can potentially collapse due to damage caused by earthquakes,which has frequently occurred around the world.This study takes the proposed valley type tailings impoundment in Yunnan as the research object to analyze the dynamic response behavior under earthquake action with both numerical simulation and physical model test(1:300).The results of both tests show that the dynamic response of the valley type tailings impoundment is characterized by"medium stiffness effect",in other words,in a certain range,the"softer"the unsaturated tailings sand is,the more energy it can dissipate,which leads the decrease of the value of the acceleration amplification factor.In addition,the peak acceleration of the monitoring points increases with the vertical elevation,which indicates that the"elevation amplification effect"exists in the tailings impoundment dynamic response.The middle part of the outer side of the raised embankment reacts more sensitive than the crest,which is similar to the slope dynamic response.The starter dam reacts sensitively under the earthquake excitation,which should be given more attention during the seismic design.The dynamic response rules reflected by the numerical simulation are consistent with the results monitored on the physical model test,although there are some differences between their values.The dynamic response rules of the valley type tailings impoundment can provide basis for the design of the similar projects in this region.
文摘The dynamic interaction problems of three-dimensional lineqr elastic structures with arbitrary shaped section embedded in a homogeneous, isotropic and linear elastic half space under dynamic disturbances are numerically solved. The numerical method employed is a combination of the time domain semi-analytical boundary element method (SBEM) used for the semi-infinite soil medium and the semi-analytical finite element method (SFEM) used for the three-dimensional structure. The two methods are combined through equilibrium and compatibility conditions at the soil-structure interface. Displacements, velocities, accelerations and interaction forces at the interface between underground structure and soil medium produced by the diffraction of wave by an underground structure for every time step are obtained. In dynamic soil-structure interaction problems, it is advantageous to combine the SBEM and the SFEM in an effort to produce an optimum numerical hybrid scheme which is characterized by the main advantages of the two methods. The effects of the thickness, the ratio of length and diameter of underground structure and the soil medium on dynamic responses are discussed.
