BACKGROUND Low back pain is a major cause of disability worldwide,with intervertebral disc degeneration contributing to nearly 40%of cases.Conventional treatments focus on symptom relief without addressing the underly...BACKGROUND Low back pain is a major cause of disability worldwide,with intervertebral disc degeneration contributing to nearly 40%of cases.Conventional treatments focus on symptom relief without addressing the underlying degeneration.Platelet-rich plasma(PRP),a regenerative therapy rich in growth factors,offers potential therapeutic benefits through growth factor-mediated mechanisms,though clinical evidence is limited.AIM To evaluate the efficacy of intradiscal autologous PRP injection in reducing pain and improving function in patients with chronic lumbar disc prolapse.METHODS This pilot quasi-experimental study was conducted in tertiary care centre between July 2022 and June 2024.The study involved comparing the outcomes between group A(n=17)who failed to respond to conservative treatment measures and received intradiscal PRP injection with group B(n=22)who responded to conservative treatment.Visual Analogue Scale(VAS)and Functional Rating Index(FRI)scores were recorded at baseline,3 weeks,and 6 weeks for both the groups.RESULTS Forty patients were enrolled in the study.The PRP group demonstrated significant improvement in VAS and FRI scores compared to baseline.While both groups improved from their respective baselines,direct between-group comparisons are limited by baseline differences in symptom severity.Patients who failed conservative trial showed significant improvement following PRP intervention,with outcomes approaching those observed in physiotherapy responders.CONCLUSION Intradiscal PRP injection significantly improved pain and function in patients with lumbar disc disease,with clinical improvements that approached the level observed in physiotherapy responders,despite baseline differences in symptom severity.PRP shows promise as an effective treatment for lumbar disc pathology;however,these preliminary findings are limited by the small sample size and short follow-up,warranting larger trials with long-term evaluation.展开更多
●AIM:To study if one of the two molecules could lead to a lower number of follow up visits and intra-vitreous injection(IVI)with the same efficacy.●METHODS:ELU(or"elected"in French)study is a retrospective...●AIM:To study if one of the two molecules could lead to a lower number of follow up visits and intra-vitreous injection(IVI)with the same efficacy.●METHODS:ELU(or"elected"in French)study is a retrospective study conducted in real life in patients presenting suboptimal response after ranibizumab IVI(phase 1)and secondary switched to aflibercept(phase 2).The number of follow up visits and IVI were compared in both phases.Visual acuity(VA)evolution and"switching"reasons were secondary analyzed.●RESULTS:We retrospectively included data of 33 patients(38 eyes)with age-related macular degeneration(AMD;mean age:77±7.7 y).The number of monthly follow up visits[median(Q1;Q3)]:was significantly lower with aflibercept(phase 2),respectively 1.0(0.81;1.49)visits in phase 1,versus 0.79(0.67;0.86)visits in phase 2.The median number of monthly IVI also significantly decreased in phase 2,respectively 0.67(0.55;0.90)IVI in phase 1,versus 0.55(0.45;0.67)IVI in phase 2.The mean VA evolution(VA final-VA initial)was similar in both phases,(P>0.05).Whatever the reason for"switching"(loss of efficacy,tachyphylaxis,tolerance problems),there was no incidence on VA evolution over the time.●CONCLUSION:Our results show that switching from ranibizumab to aflibercept in"suboptimal"patients significantly reduce the number of follow up visits and IVI,with a comparable efficacy.This decrease in visit number could improve patients’quality of life and reduce surgical risk by reducing the number of injections.展开更多
Objectives: To study the visual field changes after intravitreal ranibizumab (IVR) injection and sulfotanshinone sodium (SS) injection for macular edema (ME) secondary to retinal vein occlusion (RVO), and discuss the ...Objectives: To study the visual field changes after intravitreal ranibizumab (IVR) injection and sulfotanshinone sodium (SS) injection for macular edema (ME) secondary to retinal vein occlusion (RVO), and discuss the value of microperimetry as a routine diagnostic test in the follow-up of RVO patients. Methods: This was a retrospective, interventional, case-series study. Twelve eyes of 12 RVO patients, including 6 eyes with central RVO (CRVO) and 6 eyes with branch RVO (BRVO) were included. The eyes were treated with IVR (0.5 mg) injections and SS injections (20 mg per day, one week consecutively in one month). The outcomes measured included best corrected visual acuity (BCVA), central retinal thickness (CRT), mean defect (MD), pattern standard deviation (PSD), macular light sensitivity of the central 16 points in CRVO group and the central 8 points in BRVO group before and after the treatment. Statistical analyses were then performed on the main outcome measures. Results: An improvement of BCVA was found in all patients after treatment with significant difference (t = 7.74, p p p p > 0.05). All RVO patients had their macular light sensitivity of the involved part improved significantly (t = 5.03, p p p < 0.01). The Pearson’s correlation was calculated among BCVA, MD, macular light sensitivity and CRT. No obvious significance was found between CRT and BCVA outcomes, whereas MD and mean macular light sensitivity outcomes were closely related to BCVA results in the BRVO group and the latter showed a more intimate correlation. No similar correlation was found in RVO and CRVO group. Conclusion: IVR injection and SS injection together could effectively improve the therapeutic effect in RVO patients with ME. Microperimetry could be used as a routine diagnostic test and a possible valuable tool in the follow-up of patients with RVO, especially in BRVO.展开更多
The existing research on shrinkage of the injection molded plastic part mainly focuses on various shrinkage ratios of the part dimensions,and the relevant experimental studies belong to mere dimension measurement afte...The existing research on shrinkage of the injection molded plastic part mainly focuses on various shrinkage ratios of the part dimensions,and the relevant experimental studies belong to mere dimension measurement after demoulding.Obviously,measuring after the plastic part is demoulded from the cavity can not offer shrinkage displacements of points on the plastic part.However,shrinkage displacements of points on an injection molded plastic part are essential for exposing the inner relation among shrinkage ratios of various dimensions of the part.So visualization of the in-mold plastic part which can indicate the location relationship between the part and the cavity is needed.In this paper,a visual injection mold was fabricated by adopting the half mold structure and light transmission manner.With the visual mold,in-mold shrinkage images of injection molded plastic parts were photographed after the plastic part stayed in the injection mold for 24 h.By means of digital image processing of the in-mold shrinkage images,the experimental data of shrinkage displacements of points on injection molded parts were researched.From the experimental data,it is found that shrinkage directions of points on an injection molded part are related with both positions of the gate and of the part centroid,and either the gate or the centroid will exert more influence on the shrinkage direction of some point which is closer.Furthermore,some point at the later filled area has more shrinkage distance than the point at the earlier filled area.Combination of shrinkage directions and shrinkage distances of points on an injection molded part determine shrinkage ratios for various dimensions of the part,and shrinkage directions are more influential to shrinkage ratios of dimensions.This experimental research of shrinkage displacements offers a unique approach to understand the shrinkage principles of injection molded parts.展开更多
Background: The iStent inject is a Micro-Invasive Glaucoma Surgical (MIGS) device that has shown to reduce IOP and to be safe for glaucoma patients with fewer complications than regular surgery. Objective: To investig...Background: The iStent inject is a Micro-Invasive Glaucoma Surgical (MIGS) device that has shown to reduce IOP and to be safe for glaucoma patients with fewer complications than regular surgery. Objective: To investigate, up to 15 - 20 months, the efficacy and safety of implantation of two second-generation trabecular microbypass stents in patients with or without prior glaucoma surgery. Methods: Fifty-seven eyes were implanted with the iStent inject. The population was comprised of eyes with primary open-angle glaucoma (n = 51), pseudoexfoliation glaucoma (n = 5) and ocular hypertension (n = 1). Major outcome parameters included IOP, medication needs and corrected distance visual acuity (CDVA). Follow-up time points were one day, 2 - 4 months, 9 - 14 months and 15 - 20 months. Results: The main reason to perform MIGS was IOP reduction in 68.4%, reduced number of medications due to drug intolerance in 24.6% and reduced medication due to compliance issues in 7.0% of the eyes. IOP decreased by 22.47%, from 19.40 ± 3.83 mmHg preoperatively (preop) to 15.04 ± 1.67 mmHg at 15-20 months postoperatively. IOP reduction was achieved at all follow-up time points (p Conclusions: Insertion of the iStent inject in patients with or without prior glaucoma surgery shows effective and sustained improvements in IOP with no safety concerns.展开更多
Previous works employ the Large Language Model(LLM)like GPT-3 for knowledge-based Visual Question Answering(VQA).We argue that the inferential capacity of LLM can be enhanced through knowledge injection.Although metho...Previous works employ the Large Language Model(LLM)like GPT-3 for knowledge-based Visual Question Answering(VQA).We argue that the inferential capacity of LLM can be enhanced through knowledge injection.Although methods that utilize knowledge graphs to enhance LLM have been explored in various tasks,they may have some limitations,such as the possibility of not being able to retrieve the required knowledge.In this paper,we introduce a novel framework for knowledge-based VQA titled“Prompting Large Language Models with Knowledge-Injection”(PLLMKI).We use vanilla VQA model to inspire the LLM and further enhance the LLM with knowledge injection.Unlike earlier approaches,we adopt the LLM for knowledge enhancement instead of relying on knowledge graphs.Furthermore,we leverage open LLMs,incurring no additional costs.In comparison to existing baselines,our approach exhibits the accuracy improvement of over 1.3 and 1.7 on two knowledge-based VQA datasets,namely OK-VQA and A-OKVQA,respectively.展开更多
目的探讨雷珠单抗玻璃体腔注射配合玻璃体切割术治疗玻璃体积血(vitreous hemorrhage,VH)的临床效果。方法选取2022年4月—2023年5月丹江口市第一医院收治的86例(102眼)VH患者为研究对象,根据不同治疗方法分为对照组与观察组,每组43例(5...目的探讨雷珠单抗玻璃体腔注射配合玻璃体切割术治疗玻璃体积血(vitreous hemorrhage,VH)的临床效果。方法选取2022年4月—2023年5月丹江口市第一医院收治的86例(102眼)VH患者为研究对象,根据不同治疗方法分为对照组与观察组,每组43例(51眼)。对照组予以玻璃体切割术治疗,观察组在对照组基础上加用雷珠单抗玻璃体腔注射。比较2组的临床疗效、炎症指标水平、最佳矫正视力、生活质量及并发症发生情况。结果观察组的临床总有效率为93.02%,高于对照组的76.74%,差异有统计学意义(P<0.05)。治疗后,观察组的超敏-C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)、血管内皮生长因子(vascular endothelial growth factor,VEGF)、白细胞介素-6(interleukin-6,IL-6)水平分别为(6.05±0.09)mg/L、(35.04±7.44)ng/L、(4.32±0.95)pg/mL,低于对照组的(7.33±0.12)mg/L、(48.55±9.68)ng/L、(5.48±1.03)pg/mL,差异均有统计学意义(P<0.05)。观察组的最佳矫正视力为(0.49±0.09),高于对照组的(0.34±0.06),差异有统计学意义(P<0.05)。观察组世界卫生组织生存质量测定量表(the World Health Organization quality of life scale-brief form questionnaire,WHOQOL-BREF)评估结果中,心理领域、生理领域、环境领域、社会关系领域评分分别为(81.55±6.98)分、(70.12±6.12)分、(75.41±7.84)分、(80.56±6.42)分,高于对照组的(72.39±5.47)分、(58.34±5.66)分、(64.93±5.99)分、(71.55±5.37)分,差异均有统计学意义(P<0.05)。观察组并发症发生率为4.65%,低于对照组的20.93%,差异有统计学意义(<0.05)。结论雷珠单抗玻璃体腔注射配合玻璃体切割术治疗VH的效果确切,可改善最佳矫正视力,减轻炎症反应,减少并发症的发生,提高生活质量,此文的研究结果为VH后期规范化治疗方案的制订提供了借鉴。展开更多
AIM:To evaluate the efficacy and safety of intravitreal low-dose(1 mg)triamcinolone acetonide(TA)in Chinese acute nonarteritic anterior ischemic optic neuropathy(NAION)patients.METHODS:Twenty-eight eyes of 28 patients...AIM:To evaluate the efficacy and safety of intravitreal low-dose(1 mg)triamcinolone acetonide(TA)in Chinese acute nonarteritic anterior ischemic optic neuropathy(NAION)patients.METHODS:Twenty-eight eyes of 28 patients with acute NAION(<30d of visual acuity loss)were enrolled and given intravitreal TA(IVTA)once.Visual field(VF),best corrected visual acuity(BCVA),retinal nerve fiber layer(RNFL)thickness,ganglion cell complex(GCC)thickness,radial peripapillary capillary(RPC)density,and intraocular pressure(IOP)were evaluated at baseline and 7d,1,3,and 6mo after IVTA.RESULTS:VF and BCVA were significant improved during the follow-up according to the mean deviation(MD),visual field index(VFI),and Early Treatment Diabetic Retinopathy Study(ETDRS)scores(all P<0.001).There was no significant difference between the group that received an injection less than 14d after illness onset and the group that received an injection more than 14d after illness onset.The RNFL thickness,GCC thickness and RPC density were significantly decreased(all P<0.001).Temporary ocular hypertension was present in five eyes.CONCLUSION:Low-dose IVTA may be an alternative safe treatment option for some NAION patients in the acute stage.However,optic nerve atrophy still existed.展开更多
BACKGROUND Currently,colonoscopy still needs continuous optimization and exploration of novel alternative approaches to enhance the experience of patients during co-lonoscopy.AIM To analyze the efficacy of water infus...BACKGROUND Currently,colonoscopy still needs continuous optimization and exploration of novel alternative approaches to enhance the experience of patients during co-lonoscopy.AIM To analyze the efficacy of water infusion combined with defoamers in colono-scopy.METHODS This study included 97 patients undergoing colonoscopy from January 2024 to June 2024.The participants were categorized into two groups,namely,the control group(n=47),who underwent conventional colonoscopy,and the experimental group(n=50),who received colonoscopy using water injection combined with defoamers.A comparative analysis was then conducted on the disease detection rate(colonic polyps,colonorrhagia,colonic ulcers,colonic mucosal lesions,and others),colonoscopy duration,abdominal pain[visual analog scale(VAS)],Boston bowel preparation scale(BBPS),self-rating anxiety scale(SAS),bowel preparation comfort,complications(intestinal perforation,bleeding,nausea and vomiting,abdominal pain,and abdominal distension),and patient satisfaction.RESULTS The experimental group demonstrated a significantly higher total disease detection rate,BBPS scores,and patient satisfaction compared with the control group.Further,the research group exhibited shorter colonoscopy duration,lower VAS and SAS scores and total complication rate,and better patient comfort and satisfaction.CONCLUSION These results indicate that the combination of water injection and defoamers exhibited an overall better therapeutic effect than conventional colonoscopy,mainly reflected in higher disease detection rate,faster examination ef-ficiency,lower abdominal pain,anxiety,and complication incidences,and significantly better bowel preparation,comfort,and patient satisfaction.展开更多
文摘BACKGROUND Low back pain is a major cause of disability worldwide,with intervertebral disc degeneration contributing to nearly 40%of cases.Conventional treatments focus on symptom relief without addressing the underlying degeneration.Platelet-rich plasma(PRP),a regenerative therapy rich in growth factors,offers potential therapeutic benefits through growth factor-mediated mechanisms,though clinical evidence is limited.AIM To evaluate the efficacy of intradiscal autologous PRP injection in reducing pain and improving function in patients with chronic lumbar disc prolapse.METHODS This pilot quasi-experimental study was conducted in tertiary care centre between July 2022 and June 2024.The study involved comparing the outcomes between group A(n=17)who failed to respond to conservative treatment measures and received intradiscal PRP injection with group B(n=22)who responded to conservative treatment.Visual Analogue Scale(VAS)and Functional Rating Index(FRI)scores were recorded at baseline,3 weeks,and 6 weeks for both the groups.RESULTS Forty patients were enrolled in the study.The PRP group demonstrated significant improvement in VAS and FRI scores compared to baseline.While both groups improved from their respective baselines,direct between-group comparisons are limited by baseline differences in symptom severity.Patients who failed conservative trial showed significant improvement following PRP intervention,with outcomes approaching those observed in physiotherapy responders.CONCLUSION Intradiscal PRP injection significantly improved pain and function in patients with lumbar disc disease,with clinical improvements that approached the level observed in physiotherapy responders,despite baseline differences in symptom severity.PRP shows promise as an effective treatment for lumbar disc pathology;however,these preliminary findings are limited by the small sample size and short follow-up,warranting larger trials with long-term evaluation.
文摘●AIM:To study if one of the two molecules could lead to a lower number of follow up visits and intra-vitreous injection(IVI)with the same efficacy.●METHODS:ELU(or"elected"in French)study is a retrospective study conducted in real life in patients presenting suboptimal response after ranibizumab IVI(phase 1)and secondary switched to aflibercept(phase 2).The number of follow up visits and IVI were compared in both phases.Visual acuity(VA)evolution and"switching"reasons were secondary analyzed.●RESULTS:We retrospectively included data of 33 patients(38 eyes)with age-related macular degeneration(AMD;mean age:77±7.7 y).The number of monthly follow up visits[median(Q1;Q3)]:was significantly lower with aflibercept(phase 2),respectively 1.0(0.81;1.49)visits in phase 1,versus 0.79(0.67;0.86)visits in phase 2.The median number of monthly IVI also significantly decreased in phase 2,respectively 0.67(0.55;0.90)IVI in phase 1,versus 0.55(0.45;0.67)IVI in phase 2.The mean VA evolution(VA final-VA initial)was similar in both phases,(P>0.05).Whatever the reason for"switching"(loss of efficacy,tachyphylaxis,tolerance problems),there was no incidence on VA evolution over the time.●CONCLUSION:Our results show that switching from ranibizumab to aflibercept in"suboptimal"patients significantly reduce the number of follow up visits and IVI,with a comparable efficacy.This decrease in visit number could improve patients’quality of life and reduce surgical risk by reducing the number of injections.
文摘Objectives: To study the visual field changes after intravitreal ranibizumab (IVR) injection and sulfotanshinone sodium (SS) injection for macular edema (ME) secondary to retinal vein occlusion (RVO), and discuss the value of microperimetry as a routine diagnostic test in the follow-up of RVO patients. Methods: This was a retrospective, interventional, case-series study. Twelve eyes of 12 RVO patients, including 6 eyes with central RVO (CRVO) and 6 eyes with branch RVO (BRVO) were included. The eyes were treated with IVR (0.5 mg) injections and SS injections (20 mg per day, one week consecutively in one month). The outcomes measured included best corrected visual acuity (BCVA), central retinal thickness (CRT), mean defect (MD), pattern standard deviation (PSD), macular light sensitivity of the central 16 points in CRVO group and the central 8 points in BRVO group before and after the treatment. Statistical analyses were then performed on the main outcome measures. Results: An improvement of BCVA was found in all patients after treatment with significant difference (t = 7.74, p p p p > 0.05). All RVO patients had their macular light sensitivity of the involved part improved significantly (t = 5.03, p p p < 0.01). The Pearson’s correlation was calculated among BCVA, MD, macular light sensitivity and CRT. No obvious significance was found between CRT and BCVA outcomes, whereas MD and mean macular light sensitivity outcomes were closely related to BCVA results in the BRVO group and the latter showed a more intimate correlation. No similar correlation was found in RVO and CRVO group. Conclusion: IVR injection and SS injection together could effectively improve the therapeutic effect in RVO patients with ME. Microperimetry could be used as a routine diagnostic test and a possible valuable tool in the follow-up of patients with RVO, especially in BRVO.
基金supported by National Key Technology R & D Program of China during the 11th Five-Year Plan Period (Grant No.2006BAF04B13)
文摘The existing research on shrinkage of the injection molded plastic part mainly focuses on various shrinkage ratios of the part dimensions,and the relevant experimental studies belong to mere dimension measurement after demoulding.Obviously,measuring after the plastic part is demoulded from the cavity can not offer shrinkage displacements of points on the plastic part.However,shrinkage displacements of points on an injection molded plastic part are essential for exposing the inner relation among shrinkage ratios of various dimensions of the part.So visualization of the in-mold plastic part which can indicate the location relationship between the part and the cavity is needed.In this paper,a visual injection mold was fabricated by adopting the half mold structure and light transmission manner.With the visual mold,in-mold shrinkage images of injection molded plastic parts were photographed after the plastic part stayed in the injection mold for 24 h.By means of digital image processing of the in-mold shrinkage images,the experimental data of shrinkage displacements of points on injection molded parts were researched.From the experimental data,it is found that shrinkage directions of points on an injection molded part are related with both positions of the gate and of the part centroid,and either the gate or the centroid will exert more influence on the shrinkage direction of some point which is closer.Furthermore,some point at the later filled area has more shrinkage distance than the point at the earlier filled area.Combination of shrinkage directions and shrinkage distances of points on an injection molded part determine shrinkage ratios for various dimensions of the part,and shrinkage directions are more influential to shrinkage ratios of dimensions.This experimental research of shrinkage displacements offers a unique approach to understand the shrinkage principles of injection molded parts.
文摘Background: The iStent inject is a Micro-Invasive Glaucoma Surgical (MIGS) device that has shown to reduce IOP and to be safe for glaucoma patients with fewer complications than regular surgery. Objective: To investigate, up to 15 - 20 months, the efficacy and safety of implantation of two second-generation trabecular microbypass stents in patients with or without prior glaucoma surgery. Methods: Fifty-seven eyes were implanted with the iStent inject. The population was comprised of eyes with primary open-angle glaucoma (n = 51), pseudoexfoliation glaucoma (n = 5) and ocular hypertension (n = 1). Major outcome parameters included IOP, medication needs and corrected distance visual acuity (CDVA). Follow-up time points were one day, 2 - 4 months, 9 - 14 months and 15 - 20 months. Results: The main reason to perform MIGS was IOP reduction in 68.4%, reduced number of medications due to drug intolerance in 24.6% and reduced medication due to compliance issues in 7.0% of the eyes. IOP decreased by 22.47%, from 19.40 ± 3.83 mmHg preoperatively (preop) to 15.04 ± 1.67 mmHg at 15-20 months postoperatively. IOP reduction was achieved at all follow-up time points (p Conclusions: Insertion of the iStent inject in patients with or without prior glaucoma surgery shows effective and sustained improvements in IOP with no safety concerns.
基金supported by the National Natural Science Foundation of China(No.62272100)Consulting Project of Chinese Academy of Engineering(No.2023-XY-09)Fundamental Research Funds for the Central Universities.
文摘Previous works employ the Large Language Model(LLM)like GPT-3 for knowledge-based Visual Question Answering(VQA).We argue that the inferential capacity of LLM can be enhanced through knowledge injection.Although methods that utilize knowledge graphs to enhance LLM have been explored in various tasks,they may have some limitations,such as the possibility of not being able to retrieve the required knowledge.In this paper,we introduce a novel framework for knowledge-based VQA titled“Prompting Large Language Models with Knowledge-Injection”(PLLMKI).We use vanilla VQA model to inspire the LLM and further enhance the LLM with knowledge injection.Unlike earlier approaches,we adopt the LLM for knowledge enhancement instead of relying on knowledge graphs.Furthermore,we leverage open LLMs,incurring no additional costs.In comparison to existing baselines,our approach exhibits the accuracy improvement of over 1.3 and 1.7 on two knowledge-based VQA datasets,namely OK-VQA and A-OKVQA,respectively.
文摘目的探讨雷珠单抗玻璃体腔注射配合玻璃体切割术治疗玻璃体积血(vitreous hemorrhage,VH)的临床效果。方法选取2022年4月—2023年5月丹江口市第一医院收治的86例(102眼)VH患者为研究对象,根据不同治疗方法分为对照组与观察组,每组43例(51眼)。对照组予以玻璃体切割术治疗,观察组在对照组基础上加用雷珠单抗玻璃体腔注射。比较2组的临床疗效、炎症指标水平、最佳矫正视力、生活质量及并发症发生情况。结果观察组的临床总有效率为93.02%,高于对照组的76.74%,差异有统计学意义(P<0.05)。治疗后,观察组的超敏-C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)、血管内皮生长因子(vascular endothelial growth factor,VEGF)、白细胞介素-6(interleukin-6,IL-6)水平分别为(6.05±0.09)mg/L、(35.04±7.44)ng/L、(4.32±0.95)pg/mL,低于对照组的(7.33±0.12)mg/L、(48.55±9.68)ng/L、(5.48±1.03)pg/mL,差异均有统计学意义(P<0.05)。观察组的最佳矫正视力为(0.49±0.09),高于对照组的(0.34±0.06),差异有统计学意义(P<0.05)。观察组世界卫生组织生存质量测定量表(the World Health Organization quality of life scale-brief form questionnaire,WHOQOL-BREF)评估结果中,心理领域、生理领域、环境领域、社会关系领域评分分别为(81.55±6.98)分、(70.12±6.12)分、(75.41±7.84)分、(80.56±6.42)分,高于对照组的(72.39±5.47)分、(58.34±5.66)分、(64.93±5.99)分、(71.55±5.37)分,差异均有统计学意义(P<0.05)。观察组并发症发生率为4.65%,低于对照组的20.93%,差异有统计学意义(<0.05)。结论雷珠单抗玻璃体腔注射配合玻璃体切割术治疗VH的效果确切,可改善最佳矫正视力,减轻炎症反应,减少并发症的发生,提高生活质量,此文的研究结果为VH后期规范化治疗方案的制订提供了借鉴。
基金Supported by the National Key R&D Program of China(No.2016YFC0904800,No.2019YFC0840607)the National Science and Technology Major Project of China(No.2017ZX09304010)the Clinical Research Innovation Plan of Shanghai General Hospital(No.CTCCR-2018BP04).
文摘AIM:To evaluate the efficacy and safety of intravitreal low-dose(1 mg)triamcinolone acetonide(TA)in Chinese acute nonarteritic anterior ischemic optic neuropathy(NAION)patients.METHODS:Twenty-eight eyes of 28 patients with acute NAION(<30d of visual acuity loss)were enrolled and given intravitreal TA(IVTA)once.Visual field(VF),best corrected visual acuity(BCVA),retinal nerve fiber layer(RNFL)thickness,ganglion cell complex(GCC)thickness,radial peripapillary capillary(RPC)density,and intraocular pressure(IOP)were evaluated at baseline and 7d,1,3,and 6mo after IVTA.RESULTS:VF and BCVA were significant improved during the follow-up according to the mean deviation(MD),visual field index(VFI),and Early Treatment Diabetic Retinopathy Study(ETDRS)scores(all P<0.001).There was no significant difference between the group that received an injection less than 14d after illness onset and the group that received an injection more than 14d after illness onset.The RNFL thickness,GCC thickness and RPC density were significantly decreased(all P<0.001).Temporary ocular hypertension was present in five eyes.CONCLUSION:Low-dose IVTA may be an alternative safe treatment option for some NAION patients in the acute stage.However,optic nerve atrophy still existed.
基金Supported by Foshan City Self-Raised Funds Science and Technology Innovation Project,No.2320001007369.
文摘BACKGROUND Currently,colonoscopy still needs continuous optimization and exploration of novel alternative approaches to enhance the experience of patients during co-lonoscopy.AIM To analyze the efficacy of water infusion combined with defoamers in colono-scopy.METHODS This study included 97 patients undergoing colonoscopy from January 2024 to June 2024.The participants were categorized into two groups,namely,the control group(n=47),who underwent conventional colonoscopy,and the experimental group(n=50),who received colonoscopy using water injection combined with defoamers.A comparative analysis was then conducted on the disease detection rate(colonic polyps,colonorrhagia,colonic ulcers,colonic mucosal lesions,and others),colonoscopy duration,abdominal pain[visual analog scale(VAS)],Boston bowel preparation scale(BBPS),self-rating anxiety scale(SAS),bowel preparation comfort,complications(intestinal perforation,bleeding,nausea and vomiting,abdominal pain,and abdominal distension),and patient satisfaction.RESULTS The experimental group demonstrated a significantly higher total disease detection rate,BBPS scores,and patient satisfaction compared with the control group.Further,the research group exhibited shorter colonoscopy duration,lower VAS and SAS scores and total complication rate,and better patient comfort and satisfaction.CONCLUSION These results indicate that the combination of water injection and defoamers exhibited an overall better therapeutic effect than conventional colonoscopy,mainly reflected in higher disease detection rate,faster examination ef-ficiency,lower abdominal pain,anxiety,and complication incidences,and significantly better bowel preparation,comfort,and patient satisfaction.
