Cardiovascular diseases(CVD)are undoubtedly the leading cause of morbidity and mortality in the elderly.Population aging is a global phenomenon.In developed countries,by the year 2050 one in four people will be aged 6...Cardiovascular diseases(CVD)are undoubtedly the leading cause of morbidity and mortality in the elderly.Population aging is a global phenomenon.In developed countries,by the year 2050 one in four people will be aged 65+years.This ongoing growth of the aging population leads to an increasing burden of CVD.The management of CVD in geriatric patients requires specific considerations.Aging is associated with complex pathophysiology due to decreased organ reserve,which is clinically described as frailty.Additionally,the aging population is extremely heterogenous and frequently characterized by a combination of unique features,including atypical disease presentation,multimorbidity,polypharmacy,altered pharmacokinetics,cognitive impairment,renal impairment,dysautonomia,elevated risk of falls,sarcopenia,and frailty.Furthermore,significant gaps in evidence exist largely due to the limited representation of the very elderly,and especially frail patients,in randomized controlled trials.When combined with issues related to life expectancy,goals of care,bioethics,and patients’preferences,these factors pose intricate challenges for healthcare providers.This literature review summarizes selected clinical scenarios that often introduce dilemmas in the management of elderly patients in cardiology practice,emphasizing the intersection of geriatric medicine and cardiology.These include blood pressure management,management of dyslipidemia,anticoagulation in atrial fibrillation,medical and device treatment of heart failure,antiplatelet and interventional management of acute coronary syndromes,and peri-procedural considerations in severe aortic stenosis.The above will provide guidance for clinical practice,as well as implications for health policies and future research in the field of geriatric cardiology.展开更多
If you are to choose an event that can best represent China’s culture,undoubtedly,it will be the Spring Festival,or the Chinese Lunar New Year.It is a cherished occasion for families to get together,extend best wishe...If you are to choose an event that can best represent China’s culture,undoubtedly,it will be the Spring Festival,or the Chinese Lunar New Year.It is a cherished occasion for families to get together,extend best wishes to the people around them,and maintain friendships.展开更多
At the point of death,a human being only has had the experience of nonexistence before birth and the experience of having lived his/her life after they were born.In the final analysis from the perspective of strict em...At the point of death,a human being only has had the experience of nonexistence before birth and the experience of having lived his/her life after they were born.In the final analysis from the perspective of strict empiricism,the individual only has two options:the nonexistence before birth or the eventual reliving of one’s life.The return of one’s life is supported by the paradigm of a multiverse and an antimatter universe.This is atheism’s logical certainty.展开更多
This paper explores Emily Dickinson’s poem"I heard a Fly buzz- when I died-". Through the analysis of the unique arrangement that the poet uses to present the theme,the image of a fly and the use of dash,th...This paper explores Emily Dickinson’s poem"I heard a Fly buzz- when I died-". Through the analysis of the unique arrangement that the poet uses to present the theme,the image of a fly and the use of dash,the paper presents how the doubt and uncertainty of the poet as to the existence of God and salvation are revealed.展开更多
whether与if是我们常见又常用的两个连接词。由于二者都可以表示“是否”,故而在使用时极易混淆。现将其用法归纳如下。一、whether和if可以换用的情况 1.可用whether或if引导位于动词ask,know,tell,see,wonder,remembr,try等词之后的...whether与if是我们常见又常用的两个连接词。由于二者都可以表示“是否”,故而在使用时极易混淆。现将其用法归纳如下。一、whether和if可以换用的情况 1.可用whether或if引导位于动词ask,know,tell,see,wonder,remembr,try等词之后的宾语从句,常译为“是否”。例如: She asked whether/if I had seen him the展开更多
There is no doubt that the boxes were then put on a train for KOnigsberg,which was at that time a German city on the Baltic Sea.毫无疑问．这些箱子后来被装上火车运往哥尼斯堡，当时德国在波罗的海边的一个城市。
John Bunyan's The Pilgrim's Progress has been written to preach the glad tidings of salvation.Therefore its allegorical protagonists have gradually gone through many tests and trials on the path to salvation.T...John Bunyan's The Pilgrim's Progress has been written to preach the glad tidings of salvation.Therefore its allegorical protagonists have gradually gone through many tests and trials on the path to salvation.This paper is focused on the doctrinal instruction of the later two episodes,Doubting Castle and Enchanted Ground.展开更多
As of 12 March 2020,the WHO upgraded the status of COVID-19 from epidemic to pandemic.1 Globally,as of 20 July 2020,14707451 confirmed cases of COVID-19,including 609985 deaths,have been reported by an interactive web...As of 12 March 2020,the WHO upgraded the status of COVID-19 from epidemic to pandemic.1 Globally,as of 20 July 2020,14707451 confirmed cases of COVID-19,including 609985 deaths,have been reported by an interactive web-based dashboard released by Johns Hopkins University.2 Strict provisions and strategies have been implemented to suppress or mitigate the spread of the COVID-19 pandemic,such as government-imposed contact tracing and quarantine,lockdown,social and physical distance measures,and closure of non-essential facilities and services.The global spread of the COVID-19 pandemic and rapid escalation response undoubtedly put enormous stress on patients with confirmed or suspected COVID-19,medical personnel and even the public,increasing the risk of mental health problems.展开更多
99.8% of extant vertebrate species on Earth, including humans, possess jaws(maxilla and mandible). The group which we belong to is accordingly referred to as jawed vertebrates or gnathostomes. The origin and rise of o...99.8% of extant vertebrate species on Earth, including humans, possess jaws(maxilla and mandible). The group which we belong to is accordingly referred to as jawed vertebrates or gnathostomes. The origin and rise of our group is undoubtedly one of the most critical evolutionary milestones in the history of vertebrates from fish to humans.展开更多
Barefoot running has been around for millions of years,and it is safe to presume that for most of that time,the practice occasioned little interest.Our ancestors ran barefoot because they had no shoes.When footwear wa...Barefoot running has been around for millions of years,and it is safe to presume that for most of that time,the practice occasioned little interest.Our ancestors ran barefoot because they had no shoes.When footwear was first invented during the last 40,000 years (no doubt at different times and in different places),shoes were by necessity minimal-essentially sandals and moccasins-designed to protect the sole of the foot but lacking any of the sophisticated features and materials present in modem running shoes such as elevated cushioned heels,arch supports,and toe springs.Most of these features were invented in the 1970s,and they quickly became more popular and sophisticated as running underwent a worldwide boom.Today,the vast majority of runners think it is normal to wear cushioned running shoes,and would never dream of running without them.展开更多
The following equations are basic forms of C-K equation (which is simplified in the following as singu-lar integral equations with convolution, that is C-K equations):where a,b,a_j,b_j are known constants or known fun...The following equations are basic forms of C-K equation (which is simplified in the following as singu-lar integral equations with convolution, that is C-K equations):where a,b,a_j,b_j are known constants or known functions, and find its solution f L_P(R), {0} or {α,β}.There were rather complete investigations on the method of solution for equations of Cauchy type aswell as integral equations of convolution type. But there is not investigation to the C-K equations, nodoubt, such that is important.展开更多
There is no doubt that hydrogen(H)is becoming one of the most promising sustainable energy carriers which can release at least partially the current strong reliance on fossil fuel-based energy and the resulting enviro...There is no doubt that hydrogen(H)is becoming one of the most promising sustainable energy carriers which can release at least partially the current strong reliance on fossil fuel-based energy and the resulting environmental burden.展开更多
The doubled-haploid technique mediated by parthenogenesis and androgenesis in plants can directly generate homozygous diploid lines after chromosome doubling with colchicine in one or two generations,and this method u...The doubled-haploid technique mediated by parthenogenesis and androgenesis in plants can directly generate homozygous diploid lines after chromosome doubling with colchicine in one or two generations,and this method undoubtedly shortens the breeding process and improves breeding efficiency in crops.Previously,haploid plants were mainly induced by anther culture or microspore culture via androgenesis(Ohnoutkova et al.,2019).In wheat(Triticum aestivum),haploids can also be induced by maize(Zea mays)pollen and chromosome elimination via parthenogenesis(Liu et al.,2020b).However,the aforementioned induction methods are genotype-dependent,require complex manipulations,and are both time-consuming and inefficient.Therefore,it is necessary to develop new techniques or germplasm for simple and efficient haploid induction.展开更多
1.Updates in prostate cancer(PCa)detections 1.1.Screening of PCa The discovery of prostate specific antigen(PSA)undoubtedly marked a new era for the efficient screening of PCa.In addition,the screening of PCa has been...1.Updates in prostate cancer(PCa)detections 1.1.Screening of PCa The discovery of prostate specific antigen(PSA)undoubtedly marked a new era for the efficient screening of PCa.In addition,the screening of PCa has been the hot area of studies all the time,and it is still the most commonly discussed topic of European Association of Urology(EAU)and American Urological Association(AUA).展开更多
文摘Cardiovascular diseases(CVD)are undoubtedly the leading cause of morbidity and mortality in the elderly.Population aging is a global phenomenon.In developed countries,by the year 2050 one in four people will be aged 65+years.This ongoing growth of the aging population leads to an increasing burden of CVD.The management of CVD in geriatric patients requires specific considerations.Aging is associated with complex pathophysiology due to decreased organ reserve,which is clinically described as frailty.Additionally,the aging population is extremely heterogenous and frequently characterized by a combination of unique features,including atypical disease presentation,multimorbidity,polypharmacy,altered pharmacokinetics,cognitive impairment,renal impairment,dysautonomia,elevated risk of falls,sarcopenia,and frailty.Furthermore,significant gaps in evidence exist largely due to the limited representation of the very elderly,and especially frail patients,in randomized controlled trials.When combined with issues related to life expectancy,goals of care,bioethics,and patients’preferences,these factors pose intricate challenges for healthcare providers.This literature review summarizes selected clinical scenarios that often introduce dilemmas in the management of elderly patients in cardiology practice,emphasizing the intersection of geriatric medicine and cardiology.These include blood pressure management,management of dyslipidemia,anticoagulation in atrial fibrillation,medical and device treatment of heart failure,antiplatelet and interventional management of acute coronary syndromes,and peri-procedural considerations in severe aortic stenosis.The above will provide guidance for clinical practice,as well as implications for health policies and future research in the field of geriatric cardiology.
文摘If you are to choose an event that can best represent China’s culture,undoubtedly,it will be the Spring Festival,or the Chinese Lunar New Year.It is a cherished occasion for families to get together,extend best wishes to the people around them,and maintain friendships.
文摘At the point of death,a human being only has had the experience of nonexistence before birth and the experience of having lived his/her life after they were born.In the final analysis from the perspective of strict empiricism,the individual only has two options:the nonexistence before birth or the eventual reliving of one’s life.The return of one’s life is supported by the paradigm of a multiverse and an antimatter universe.This is atheism’s logical certainty.
文摘This paper explores Emily Dickinson’s poem"I heard a Fly buzz- when I died-". Through the analysis of the unique arrangement that the poet uses to present the theme,the image of a fly and the use of dash,the paper presents how the doubt and uncertainty of the poet as to the existence of God and salvation are revealed.
文摘whether与if是我们常见又常用的两个连接词。由于二者都可以表示“是否”,故而在使用时极易混淆。现将其用法归纳如下。一、whether和if可以换用的情况 1.可用whether或if引导位于动词ask,know,tell,see,wonder,remembr,try等词之后的宾语从句,常译为“是否”。例如: She asked whether/if I had seen him the
文摘There is no doubt that the boxes were then put on a train for KOnigsberg,which was at that time a German city on the Baltic Sea.毫无疑问．这些箱子后来被装上火车运往哥尼斯堡，当时德国在波罗的海边的一个城市。
文摘John Bunyan's The Pilgrim's Progress has been written to preach the glad tidings of salvation.Therefore its allegorical protagonists have gradually gone through many tests and trials on the path to salvation.This paper is focused on the doctrinal instruction of the later two episodes,Doubting Castle and Enchanted Ground.
文摘As of 12 March 2020,the WHO upgraded the status of COVID-19 from epidemic to pandemic.1 Globally,as of 20 July 2020,14707451 confirmed cases of COVID-19,including 609985 deaths,have been reported by an interactive web-based dashboard released by Johns Hopkins University.2 Strict provisions and strategies have been implemented to suppress or mitigate the spread of the COVID-19 pandemic,such as government-imposed contact tracing and quarantine,lockdown,social and physical distance measures,and closure of non-essential facilities and services.The global spread of the COVID-19 pandemic and rapid escalation response undoubtedly put enormous stress on patients with confirmed or suspected COVID-19,medical personnel and even the public,increasing the risk of mental health problems.
文摘99.8% of extant vertebrate species on Earth, including humans, possess jaws(maxilla and mandible). The group which we belong to is accordingly referred to as jawed vertebrates or gnathostomes. The origin and rise of our group is undoubtedly one of the most critical evolutionary milestones in the history of vertebrates from fish to humans.
文摘Barefoot running has been around for millions of years,and it is safe to presume that for most of that time,the practice occasioned little interest.Our ancestors ran barefoot because they had no shoes.When footwear was first invented during the last 40,000 years (no doubt at different times and in different places),shoes were by necessity minimal-essentially sandals and moccasins-designed to protect the sole of the foot but lacking any of the sophisticated features and materials present in modem running shoes such as elevated cushioned heels,arch supports,and toe springs.Most of these features were invented in the 1970s,and they quickly became more popular and sophisticated as running underwent a worldwide boom.Today,the vast majority of runners think it is normal to wear cushioned running shoes,and would never dream of running without them.
文摘The following equations are basic forms of C-K equation (which is simplified in the following as singu-lar integral equations with convolution, that is C-K equations):where a,b,a_j,b_j are known constants or known functions, and find its solution f L_P(R), {0} or {α,β}.There were rather complete investigations on the method of solution for equations of Cauchy type aswell as integral equations of convolution type. But there is not investigation to the C-K equations, nodoubt, such that is important.
文摘There is no doubt that hydrogen(H)is becoming one of the most promising sustainable energy carriers which can release at least partially the current strong reliance on fossil fuel-based energy and the resulting environmental burden.
基金supported by the Agricultural Science and Technology Innovation Program of Chinese Academy of Agricultural Sciences(S2021ZD03 and 2060302-2-19).
文摘The doubled-haploid technique mediated by parthenogenesis and androgenesis in plants can directly generate homozygous diploid lines after chromosome doubling with colchicine in one or two generations,and this method undoubtedly shortens the breeding process and improves breeding efficiency in crops.Previously,haploid plants were mainly induced by anther culture or microspore culture via androgenesis(Ohnoutkova et al.,2019).In wheat(Triticum aestivum),haploids can also be induced by maize(Zea mays)pollen and chromosome elimination via parthenogenesis(Liu et al.,2020b).However,the aforementioned induction methods are genotype-dependent,require complex manipulations,and are both time-consuming and inefficient.Therefore,it is necessary to develop new techniques or germplasm for simple and efficient haploid induction.
文摘1.Updates in prostate cancer(PCa)detections 1.1.Screening of PCa The discovery of prostate specific antigen(PSA)undoubtedly marked a new era for the efficient screening of PCa.In addition,the screening of PCa has been the hot area of studies all the time,and it is still the most commonly discussed topic of European Association of Urology(EAU)and American Urological Association(AUA).
