Objective This study attempted to seek a new Doppler-derived index for estimating ventricularsystolic function. Methods With custom - made software the aortic and pulmonic flow profiles were digitized andconverted to ...Objective This study attempted to seek a new Doppler-derived index for estimating ventricularsystolic function. Methods With custom - made software the aortic and pulmonic flow profiles were digitized andconverted to their 4V2 curves, their maximum value of the first derivative, max (dk/dt) were obtained separately in23 and 25patients with congenital heart disease (mean age 4.5 years). Aortic max(dk/dt) and pulmonic max(dk/dt)measured by Doppler were compared with left ventricular max(dp/dt) and right ventricular max(dp/dt) measuredby cardiac catheterization. Results Aortic max(dk/dt) correlated well with LV max(dp/dt) (r=0.817, P<0.001).An excellent correlation of pulmonic max(dk/dt) with RV max(dp/dt) was established (r=0.926, P<0.0001). Therewas a significant correlation between RVSP and RV max(dp/dt) (r= 0.839, P<0.0001). Conclusion Doppler - derived aortic max(dk/dt) and pulmonic max(dk/dt) could be reliable index of left ventricular contractility and rightventricular contractility respectively. When max(dp/dt) is used for assessing RV systolic function, the impact ofRVSP on that should be taken into consideration.展开更多
Background Recent studies demonstrated that N-terminal pro-brain natriuretic peptide（NT-pro BNP） increases in patients with diabetes mellitus and raised concerns about the diagnostic validity of NT-pro BNP in assess...Background Recent studies demonstrated that N-terminal pro-brain natriuretic peptide（NT-pro BNP） increases in patients with diabetes mellitus and raised concerns about the diagnostic validity of NT-pro BNP in assessment of cardiac function in patients with hyperglycemia.Current investigation was carried out to observe the influence of hyperglycemia on the correlation of NT-pro BNP and cardiac function index in patients with acute coronary syndrome（ACS）.Methods Fifty patients with ACS were enrolled and divided into hyperglycemia group（fasting plasma glucose（FPG） ≥ 6.1 mmol/L） and euglycemia group（FPG 〈 6.1 mmol/L）.All the patients underwent routine transthoracic ecocardiagraphy and tissue Doppler imaging（TDI） investigation.Blood sample were obtained with 24 hours of hospitalization for measuring of NT-proBNP level.Relation between TDI-Tei index and the level of NT-proBNP were analyzed in the two groups respectively.Result TDI-Tei index,systolic index and diastolic index were all significantly higher in hyperglycemia group than that in euglycemia group（0.679 ± 0.139 vs 0.600 ± 0.093,P = 0.022;0.294 ± 0.074 vs 0.258 ± 0.035,P = 0.036;0.385 ± 0.069 vs 0.342 ± 0.068,P = 0.032）.TDI-Tei index was significantly negatively correlated with the level of log NT-pro BNP in both hyperglycemia group and euglycemia group（rp = 0.673,P = 0.000;rp = 0.354,P = 0.000）.Conclusions（1）Cardiac function in patients with ACS complicated with hyperglycemia is inferior to that in patients with euglycemia;（2）Assessment of cardiac function with NT-proBNP is reliable in patients with hyperglycemia.展开更多
Objectives: To evaluate the association of diastolic function of the left ventricle with flowme-diated dilatation (FMD) in uncomplicated Type 2 diabetes mellitus patients. Methods: Eighty-two uncomplicated Type 2 diab...Objectives: To evaluate the association of diastolic function of the left ventricle with flowme-diated dilatation (FMD) in uncomplicated Type 2 diabetes mellitus patients. Methods: Eighty-two uncomplicated Type 2 diabetic patients were examined by pulse and tissue Doppler echocardiography and FMD of brachial artery. The patients were divided into 2 groups according to the size of the left ventricular relaxation parameter—E’. Results: The average age of the patients was 61 ± 6 years. FMD was 5.0 ± 1.8% in 41 patients with E’ from 3 to 7.4 cm/s (mean 6 cm/s) comparing to 5.1 ± 1.9% (p = 0.96) in 41 patients with E’ from 7.5 to 10.9 cm/s (mean 8.9 cm/s). E/E’ was 11.2 ± 2.3 in the group with lower E’ and 9.1 ± 1.6 in the group with higher E’ (p 0.001). Linear negative correlation was found between E/E’ and FMD for the patients with E’ from 3 to 7.4 cm/s (R2 = 0.131;p = 0.025) but not for the group of patients with the higher E’. The significant association between FMD and E/E’ was confirmed by multivariate analysis ((Rc)2 = 0.233;p 0.05). Conclusion: FMD has no impact on the left ventricular relaxation. However FMD is negatively associated with E/E’ in Type 2 diabetic patients who have low E’ as a sign of an impaired early relaxation.展开更多
Objective：To assess the effect of Shenmai Injection（参麦注射液,SMI） on left ventricular diastolic function（LVDF） in patients with chronic heart failure（CHF） by tissue Doppler imaging（TDI）.Methods：Sixty-four ...Objective：To assess the effect of Shenmai Injection（参麦注射液,SMI） on left ventricular diastolic function（LVDF） in patients with chronic heart failure（CHF） by tissue Doppler imaging（TDI）.Methods：Sixty-four CHF patients were randomly assigned to two groups,the observation group and the control group.Basic treatment including polarized liquid therapy was given to all the patients.In addition,SMI was given to patients of the observation group.The treatment duration was 14 days.TDI was performed in all the patients 3 days prior to the initiation of the treatment and one week after the medication to measure the average movement velocity of the mitral ring of the left ventricle at the early systolic stage and late diastolic stage（Ea and Aa）;the outcomes were compared with the corresponding parameters obtained from blood flow Doppler echocardiography, namely,the velocity of the E-wave（E） and A-wave（A）.Results：After treatment,Ea and Ea/Aa increased and Aa decreased significantly in the observation group（P〈0.05）.In the control group,although some improvement was seen,there was no statistically significant change（P〉0.05）.No statistical significance was shown between groups in these parameters after treatment.Conclusion：TDI assessment shows that SMI could effectively improve the LVDF in CHF patients.展开更多
文摘Objective This study attempted to seek a new Doppler-derived index for estimating ventricularsystolic function. Methods With custom - made software the aortic and pulmonic flow profiles were digitized andconverted to their 4V2 curves, their maximum value of the first derivative, max (dk/dt) were obtained separately in23 and 25patients with congenital heart disease (mean age 4.5 years). Aortic max(dk/dt) and pulmonic max(dk/dt)measured by Doppler were compared with left ventricular max(dp/dt) and right ventricular max(dp/dt) measuredby cardiac catheterization. Results Aortic max(dk/dt) correlated well with LV max(dp/dt) (r=0.817, P<0.001).An excellent correlation of pulmonic max(dk/dt) with RV max(dp/dt) was established (r=0.926, P<0.0001). Therewas a significant correlation between RVSP and RV max(dp/dt) (r= 0.839, P<0.0001). Conclusion Doppler - derived aortic max(dk/dt) and pulmonic max(dk/dt) could be reliable index of left ventricular contractility and rightventricular contractility respectively. When max(dp/dt) is used for assessing RV systolic function, the impact ofRVSP on that should be taken into consideration.
基金supported by Science and Technology Planning Project of Guangdong Province,China (2007B031505009)
文摘Background Recent studies demonstrated that N-terminal pro-brain natriuretic peptide（NT-pro BNP） increases in patients with diabetes mellitus and raised concerns about the diagnostic validity of NT-pro BNP in assessment of cardiac function in patients with hyperglycemia.Current investigation was carried out to observe the influence of hyperglycemia on the correlation of NT-pro BNP and cardiac function index in patients with acute coronary syndrome（ACS）.Methods Fifty patients with ACS were enrolled and divided into hyperglycemia group（fasting plasma glucose（FPG） ≥ 6.1 mmol/L） and euglycemia group（FPG 〈 6.1 mmol/L）.All the patients underwent routine transthoracic ecocardiagraphy and tissue Doppler imaging（TDI） investigation.Blood sample were obtained with 24 hours of hospitalization for measuring of NT-proBNP level.Relation between TDI-Tei index and the level of NT-proBNP were analyzed in the two groups respectively.Result TDI-Tei index,systolic index and diastolic index were all significantly higher in hyperglycemia group than that in euglycemia group（0.679 ± 0.139 vs 0.600 ± 0.093,P = 0.022;0.294 ± 0.074 vs 0.258 ± 0.035,P = 0.036;0.385 ± 0.069 vs 0.342 ± 0.068,P = 0.032）.TDI-Tei index was significantly negatively correlated with the level of log NT-pro BNP in both hyperglycemia group and euglycemia group（rp = 0.673,P = 0.000;rp = 0.354,P = 0.000）.Conclusions（1）Cardiac function in patients with ACS complicated with hyperglycemia is inferior to that in patients with euglycemia;（2）Assessment of cardiac function with NT-proBNP is reliable in patients with hyperglycemia.
文摘Objectives: To evaluate the association of diastolic function of the left ventricle with flowme-diated dilatation (FMD) in uncomplicated Type 2 diabetes mellitus patients. Methods: Eighty-two uncomplicated Type 2 diabetic patients were examined by pulse and tissue Doppler echocardiography and FMD of brachial artery. The patients were divided into 2 groups according to the size of the left ventricular relaxation parameter—E’. Results: The average age of the patients was 61 ± 6 years. FMD was 5.0 ± 1.8% in 41 patients with E’ from 3 to 7.4 cm/s (mean 6 cm/s) comparing to 5.1 ± 1.9% (p = 0.96) in 41 patients with E’ from 7.5 to 10.9 cm/s (mean 8.9 cm/s). E/E’ was 11.2 ± 2.3 in the group with lower E’ and 9.1 ± 1.6 in the group with higher E’ (p 0.001). Linear negative correlation was found between E/E’ and FMD for the patients with E’ from 3 to 7.4 cm/s (R2 = 0.131;p = 0.025) but not for the group of patients with the higher E’. The significant association between FMD and E/E’ was confirmed by multivariate analysis ((Rc)2 = 0.233;p 0.05). Conclusion: FMD has no impact on the left ventricular relaxation. However FMD is negatively associated with E/E’ in Type 2 diabetic patients who have low E’ as a sign of an impaired early relaxation.
文摘Objective：To assess the effect of Shenmai Injection（参麦注射液,SMI） on left ventricular diastolic function（LVDF） in patients with chronic heart failure（CHF） by tissue Doppler imaging（TDI）.Methods：Sixty-four CHF patients were randomly assigned to two groups,the observation group and the control group.Basic treatment including polarized liquid therapy was given to all the patients.In addition,SMI was given to patients of the observation group.The treatment duration was 14 days.TDI was performed in all the patients 3 days prior to the initiation of the treatment and one week after the medication to measure the average movement velocity of the mitral ring of the left ventricle at the early systolic stage and late diastolic stage（Ea and Aa）;the outcomes were compared with the corresponding parameters obtained from blood flow Doppler echocardiography, namely,the velocity of the E-wave（E） and A-wave（A）.Results：After treatment,Ea and Ea/Aa increased and Aa decreased significantly in the observation group（P〈0.05）.In the control group,although some improvement was seen,there was no statistically significant change（P〉0.05）.No statistical significance was shown between groups in these parameters after treatment.Conclusion：TDI assessment shows that SMI could effectively improve the LVDF in CHF patients.
