The analytical mathematical solutions of gas concentration and fractional gas loss for the diffusion of gas in a cylindrical coal sample were given with detailed mathematical derivations by assuming that the diffusion...The analytical mathematical solutions of gas concentration and fractional gas loss for the diffusion of gas in a cylindrical coal sample were given with detailed mathematical derivations by assuming that the diffusion of gas through the coal matrix is concentration gradient-driven and obeys the Fick’s Second Law of Diffusion.The analytical solutions were approximated in case of small values of time and the error analyses associated with the approximation were also undertaken.The results indicate that the square root relationship of gas release in the early stage of desorption,which is widely used to provide a simple and fast estimation of the lost gas,is the first term of the approximation,and care must be taken in using the square root relationship as a significant error might be introduced with increase in the lost time and decrease in effective diameter of a cylindrical coal sample.展开更多
This paper presents an assessment of air quality of the Kathmandu valley, capital city of Nepal. This is the largest urbanized area in the country of about 300 km2. In the last two decades an intensive development of ...This paper presents an assessment of air quality of the Kathmandu valley, capital city of Nepal. This is the largest urbanized area in the country of about 300 km2. In the last two decades an intensive development of demographic, traffic and industry growth in the region was observed which was reflected on the air quality degradation. In order to evaluate the urban air quality in Kathmandu, a field monitoring network for particle deposition, nitrogen dioxide （NO2） and sulphur dioxide （SO2） by passive sampling with high space resolution was implemented in co-operation with IVL-Sweden. The net work composed of 60 monitoring sites distributed in a grid of 1 × 1 km2 covering all over the main city and some rural valley. Monitoring were carried out for two seasons, rainy and dry as two campaign monitoring. The diffusive samplers were prepared and analyzed in IVL, Sweden. Good agreements in particle deposition between the two campaigns were observed. The particle deposition to the surrogate surface varied between 3 and 608 μg@cm2·monthl for the monitoring periods. The NOz concentrations on the other hand were quite similar in the two campaigns, and the SO2 concentrations were much lower in the first campaign compared to the second. The ranges of NO2 and SO2 concentrations were found to be from 5.6 to 52.6 μg/m3 and 0.6 to 23.4 μg·m-3 respectively. Arc Info/Arc map GIS 9.2 software was used for production of maps of spatial distribution of all the three parameters in the valley. Seasonal variation and traffic influence were also studied. Local meteorological effects in the distribution of pollutants were clearly observed and the NO2 concentrations were strictly related with traffic intensity.展开更多
The sample preparation of samples conlaining bovine serum albumin（BSA）,e.g..as used in transdermal Franz diffusion cell（FDC） solutions,was evaluated using an analytical qualily-by-design（QbD）approach.Traditional...The sample preparation of samples conlaining bovine serum albumin（BSA）,e.g..as used in transdermal Franz diffusion cell（FDC） solutions,was evaluated using an analytical qualily-by-design（QbD）approach.Traditional precipitation of BSA by adding an equal volume of organic solvent,often successfully used with conventional HPLC-PDA,was found insufficiently robust when novel fused-core HPLC and/or UPLC-MS methods were used.In this study,three factors（acetonitrile（%）.formic acid（%） and boiling time（min）） were included in the experimental design to determine an optimal and more suitable sample treatment of BSAcontaining FDC solutions.Using a QbD and Derringer desirability（D） approach,combining BSA loss,dilution factor and variability,we constructed an optimal working space with the edge of failure defined as D〈0.9.The design space is modelled and is confirmed to have an ACN range of 83 ± 3% and FA content of 1 ±0.25%.展开更多
基金provided by the Science and Technology Grant of Huainan City of China (No.2013A4001)the Key Research Grant of Shanxi Province of China (No.201303027-1)
文摘The analytical mathematical solutions of gas concentration and fractional gas loss for the diffusion of gas in a cylindrical coal sample were given with detailed mathematical derivations by assuming that the diffusion of gas through the coal matrix is concentration gradient-driven and obeys the Fick’s Second Law of Diffusion.The analytical solutions were approximated in case of small values of time and the error analyses associated with the approximation were also undertaken.The results indicate that the square root relationship of gas release in the early stage of desorption,which is widely used to provide a simple and fast estimation of the lost gas,is the first term of the approximation,and care must be taken in using the square root relationship as a significant error might be introduced with increase in the lost time and decrease in effective diameter of a cylindrical coal sample.
文摘This paper presents an assessment of air quality of the Kathmandu valley, capital city of Nepal. This is the largest urbanized area in the country of about 300 km2. In the last two decades an intensive development of demographic, traffic and industry growth in the region was observed which was reflected on the air quality degradation. In order to evaluate the urban air quality in Kathmandu, a field monitoring network for particle deposition, nitrogen dioxide （NO2） and sulphur dioxide （SO2） by passive sampling with high space resolution was implemented in co-operation with IVL-Sweden. The net work composed of 60 monitoring sites distributed in a grid of 1 × 1 km2 covering all over the main city and some rural valley. Monitoring were carried out for two seasons, rainy and dry as two campaign monitoring. The diffusive samplers were prepared and analyzed in IVL, Sweden. Good agreements in particle deposition between the two campaigns were observed. The particle deposition to the surrogate surface varied between 3 and 608 μg@cm2·monthl for the monitoring periods. The NOz concentrations on the other hand were quite similar in the two campaigns, and the SO2 concentrations were much lower in the first campaign compared to the second. The ranges of NO2 and SO2 concentrations were found to be from 5.6 to 52.6 μg/m3 and 0.6 to 23.4 μg·m-3 respectively. Arc Info/Arc map GIS 9.2 software was used for production of maps of spatial distribution of all the three parameters in the valley. Seasonal variation and traffic influence were also studied. Local meteorological effects in the distribution of pollutants were clearly observed and the NO2 concentrations were strictly related with traffic intensity.
基金the Special Research Fund of Ghent University(BOF 01D23812 to Lien Taevernier and BOF O1J22510 to Evelien Wynendaele and Professor Bart De Spiegeleer)the Institute for the Promotion of Innovation through Science and Technology in Flanders(IWT 101529 to Matthias D'Hondt)for their financial funding
文摘The sample preparation of samples conlaining bovine serum albumin（BSA）,e.g..as used in transdermal Franz diffusion cell（FDC） solutions,was evaluated using an analytical qualily-by-design（QbD）approach.Traditional precipitation of BSA by adding an equal volume of organic solvent,often successfully used with conventional HPLC-PDA,was found insufficiently robust when novel fused-core HPLC and/or UPLC-MS methods were used.In this study,three factors（acetonitrile（%）.formic acid（%） and boiling time（min）） were included in the experimental design to determine an optimal and more suitable sample treatment of BSAcontaining FDC solutions.Using a QbD and Derringer desirability（D） approach,combining BSA loss,dilution factor and variability,we constructed an optimal working space with the edge of failure defined as D〈0.9.The design space is modelled and is confirmed to have an ACN range of 83 ± 3% and FA content of 1 ±0.25%.
