[Objective] The research aimed to study design and development of system platform of 'study on relationship between natural phenology and climate change' based on WEB and GIS. [Method] Relied on the technologi...[Objective] The research aimed to study design and development of system platform of 'study on relationship between natural phenology and climate change' based on WEB and GIS. [Method] Relied on the technologies of WEB and GIS, a set of system platform of 'study on relationship between natural phenology and climate change' was developed based on the hybrid architecture of C/S (Client/Server) and B/S (Browser/Server). Moreover, its establishing process and functional module were detailedly introduced. [Result] The natural phenology and climate change in Guangxi were research objects of system platform of 'study on relationship between natural phenology and climate change'. By combining WEB and GIS with database, the primary application of 'study on relationship between natural phenology and climate change' was realized. The system used hybrid architecture of C/S and B/S. The four-layer architectures were independent to improve security, stability and maintainability of system. The visual interface on the foreground was simply, clear and easy to use. The generating program of GIS three-dimensional graph on the background was real-time and high-efficiency, providing powerful guarantee for stable and safe operation of phenology research work process. The system had functions of inquiry, analysis, statistical diagram, GIS three-dimensional graph and data export. Through the analysis of natural phenology observation data, the system could find variation rule of natural phenology as three-dimensional space (longitude, latitude and altitude) and its relationship with climate change. [Conclusion] The research laid good foundation for further deeply carrying out application of 'study on relationship between natural phenology and climate change', and also provided reference basis for recognizing nature and using change rule of phenology to execute production scheduling and strategic decision (seed-introduction and regionalization).展开更多
Human brain development is a complex process,and animal models often have significant limitations.To address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-li...Human brain development is a complex process,and animal models often have significant limitations.To address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and disease.To enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid culture.This involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid system.This cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology testing.As a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental toxins.Brain organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature differentiation.Cadmium exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic locations.The convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.展开更多
To advance intelligent construction,standards must come first.The Ministry of Housing and Urban-Rural Development has issued the List for Replicable Experience and Practices for Developing Intelligent Construction fou...To advance intelligent construction,standards must come first.The Ministry of Housing and Urban-Rural Development has issued the List for Replicable Experience and Practices for Developing Intelligent Construction four times successively and the Technical Guidelines for Intelligent Construction(Trial).展开更多
Governance debates gained strong momentum in Africa in early December 2025 as the China-Kenya Readers Forum on Xi Jinping:The Governance of China convened in Nairobi on 1 December 2025,followed by a promotional event ...Governance debates gained strong momentum in Africa in early December 2025 as the China-Kenya Readers Forum on Xi Jinping:The Governance of China convened in Nairobi on 1 December 2025,followed by a promotional event for the English edition of the book’s fifth volume on 3 December 2025 in Johannesburg,South Africa.展开更多
Macrophages in the brain barrier system include microglia in the brain parenchyma,border-associated macrophages at the brain’s borders,and recruited macrophages.They are responsible for neural development,maintenance...Macrophages in the brain barrier system include microglia in the brain parenchyma,border-associated macrophages at the brain’s borders,and recruited macrophages.They are responsible for neural development,maintenance of homeostasis,and orchestrating immune responses.With the rapid exploitation and development of new technologies,there is a deeper understanding of macrophages in the brain barrier system.Here we review the origin,development,important molecules,and functions of macrophages,mainly focusing on microglia and border-associated macrophages.We also highlight some advances in single-cell sequencing and significant cell markers.We anticipate that more advanced methods will emerge to study resident and recruited macrophages in the future,opening new horizons for neuroimmunology and related peripheral immune fields.展开更多
N6-methyladenosine(m^(6)A)modification,the most abundant internal modification in messenger RNA(mRNA)and long non-coding RNA(lncRNA),has emerged as a critical epitranscriptomic regulatory mechanism in eukaryotes.While...N6-methyladenosine(m^(6)A)modification,the most abundant internal modification in messenger RNA(mRNA)and long non-coding RNA(lncRNA),has emerged as a critical epitranscriptomic regulatory mechanism in eukaryotes.While the importance of m^(6)A modification in various biological processes has been recognized,a comprehensive understanding of its diverse roles in plant biology and agricultural applications remains fragmented.This review analyzes recent advances inm^(6)A modification's biological functions in plants.m^(6)A modification plays crucial roles in multiple aspects of plant life,including seed germination,organ development,and reproductive structure formation.Furthermore,m^(6)A has been found to significantly influence plant responses to environmental stresses,including salt,drought,temperature,and heavy metal exposure.We also uncover m^(6)A involvement in important agricultural traits.This review provides insights into the mechanistic understanding of m^(6)A modification in plants and highlights its applications in agricultural improvement,offering a foundation for future research in crop enhancement and stress resistance.展开更多
The early developmental period is a critical window during which brain cells mature and contribute to both brain development and later life functions.Gamma-aminobutyric acid(GABA),recognized as a major neurotransmitte...The early developmental period is a critical window during which brain cells mature and contribute to both brain development and later life functions.Gamma-aminobutyric acid(GABA),recognized as a major neurotransmitter,plays a crucial role in coordinating synapse formation,neuronal proliferation,and migration during this time.展开更多
Environmental DNA(eDNA)technology has revolutionized biodiversity monitoring with its non-invasive,sensitive,and cost-efficient approach.This paper systematically reviews eDNA advancements,examining its applications i...Environmental DNA(eDNA)technology has revolutionized biodiversity monitoring with its non-invasive,sensitive,and cost-efficient approach.This paper systematically reviews eDNA advancements,examining its applications in aquatic and terrestrial ecosystems and assessing China’s standardization progress.It delineates four developmental phases from single-species detection to high-throughput sequencing,and highlights China’s contribution to the development of technical standards.While significant progress has been made,challenges persist in quantitative accuracy,methodological consistency,and large-scale implementation.Future efforts should prioritize enhanced standardization,improved quantification techniques,broader applications,and international collaboration to drive innovation in eDNA technology.展开更多
Floodplain wetlands are invaluable ecosystems providing numerous ecological benefits,yet they face a global crisis necessitating sustainable preservation efforts.This study examines the depletion of floodplain wetland...Floodplain wetlands are invaluable ecosystems providing numerous ecological benefits,yet they face a global crisis necessitating sustainable preservation efforts.This study examines the depletion of floodplain wetlands within the Hastinapur Wildlife Sanctuary(HWLS)in Uttar Pradesh.Encroachment activities such as grazing,agriculture,and human settlements have fragmented and degraded critical wetland ecosystems.Additionally,irrigation projects,dam construction,and water diversion have disrupted natural water flow and availability.To assess wetland inundation in 2023,five classification techniques were employed:Random Forest(RF),Support Vector Machine(SVM),artificial neural network(ANN),Spectral Information Divergence(SID),and Maximum Likelihood Classifier(MLC).SVM emerged as the most precise method,as determined by kappa coefficient and index-based validation.Consequently,the SVM classifier was used to model wetland inundation areas from 1983 to 2023 and analyze spatiotemporal changes and fragmentation patterns.The findings revealed that the SVM clas-sifier accurately mapped 2023 wetland areas.The modeled time-series data demonstrated a 62.55%and 38.12%reduction in inundated wetland areas over the past 40 years in the pre-and post-monsoon periods,respectively.Fragmentation analysis indicated an 86.27%decrease in large core wetland areas in the pre-monsoon period,signifying severe habitat degradation.This rapid decline in wetlands within protected areas raises concerns about their ecological impacts.By linking wetland loss to global sustainability objectives,this study underscores the global urgency for strengthened wetland protection measures and highlights the need for integrating wetland conservation into broader sustainable development goals.Effective policies and adaptive management strategies are crucial for preserving these ecosystems and their vital services,which are essential for biodiversity,climate regulation,and human well-being.展开更多
This study examined the role of green energy development in mitigating climate change and fostering sustainable development in Central Asia including Kazakhstan,Uzbekistan,Kyrgyzstan,Tajikistan,and Turkmenistan.The re...This study examined the role of green energy development in mitigating climate change and fostering sustainable development in Central Asia including Kazakhstan,Uzbekistan,Kyrgyzstan,Tajikistan,and Turkmenistan.The region has substantial untapped potential in solar energy,wind energy,hydropower energy,as well as biomass and bioenergy,positioning it strategically for renewable energy deployment.The result demonstrated that integrating renewable energy can reduce greenhouse gas emissions,improve air quality,enhance energy security,and support rural development.Case studies from Kazakhstan,Uzbekistan,Kyrgyzstan,and Tajikistan showed measurable environmental and economic benefits.However,the large-scale use of renewable energy still faces numerous barriers,including outdated infrastructure,fragmented regulatory frameworks,limited investment,and shortages of technical expertise.Overcoming these obstacles requires institutional reform,stronger regional cooperation,and increasing engagement from international financial institutions and private investors.Modernizing grids,deploying storage systems,and investing in education,research,and innovation are critical for building human capacity in renewable energy sector.Accelerating the renewable energy transition is essential for Central Asia to meet climate goals,enhance environmental resilience,and ensure long-term socioeconomic development through innovation,investment,and regional collaboration.展开更多
Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables th...Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables this dynamic is the white matter(WM),known to be affected in neurodevelopmental disorders(NDDs)(Rokach et al.,2024).WM formation is mediated by myelination,a multifactorial process driven by neuro-glia interactions dependent on proper neuronal functionality(Simons and Trajkovic,2006).Another key aspect of neurodevelopmental abnormalities involves neuronal dynamics and function,with recent advances significantly enhancing our understanding of both neuronal and glial mitochondrial function(Devine and Kittler,2018;Rojas-Charry et al.,2021).Energy homeostasis in neurons,attributed largely to mitochondrial function,is critical for proper functionality and interactions with oligodendrocytes(OLs),the cells forming myelin in the brain’s WM.We herein discuss the interplay between these processes and speculate on potential dysfunction in NDDs.展开更多
This study examines the methods to plan the development of offshore oilfields over the years,which are used to support the decision-making on the development of offshore oilfields.About 100 papers are analysed and cat...This study examines the methods to plan the development of offshore oilfields over the years,which are used to support the decision-making on the development of offshore oilfields.About 100 papers are analysed and categorised into different groups of main early-stage decisions.The present study stands in contrast to the contributions of the operations research and system engineering review articles,on the one hand,and the petroleum engineering review articles,on the other.This is because it does not focus on one methodological approach,nor does it limit the literature analysis by offshore oilfield characteristics.Consequently,the present analysis may offer valuable insights,for instance,by identifying environmental planning decisions as a recent yet highly significant concern that is currently being imposed on decision-making process.Thus,it is evident that the incorporation of safety criteria within the technical-economic decision-making process for the design of production systems would be a crucial requirement at development phase.展开更多
This study investigates the coordination between regional economic growth and ecological sustainability within the context of high-quality town economy development.To address the challenges of balancing economic expan...This study investigates the coordination between regional economic growth and ecological sustainability within the context of high-quality town economy development.To address the challenges of balancing economic expansion with environmental protection,a comprehensive evaluation index system is constructed,encompassing two key dimensions:regional economy and ecological environment.Using panel data from 2013 to 2022,the coupling coordination degree model is employed to quantify the interactions and synergy between these dimensions.Additionally,spatial econometric methods are applied to calculate both global and local Moran’s Index,revealing spatial clustering patterns,regional disparities,and heterogeneity.The relative development model further identifies critical factors influencing regional coordination,with a focus on the lagging development of basic infrastructure and public services.The findings demonstrate a positive temporal trend toward improved regional coordination and reduced development gaps,with a spatial pattern characterized by higher coupling degrees in eastern and central regions compared to western areas.Based on these results,this study proposes actionable strategies to enhance coordinated development,emphasizing ecological conservation,the establishment of green production and consumption systems,ecological restoration,and strengthened municipal collaboration.This revised abstract emphasizes the study’s purpose,methods,and key findings more clearly while maintaining a professional and concise tone.Finally,based on the above analysis results,the corresponding coordinated development suggestions of regional economy and ecological environment are given from the aspects of ecological environment protection measures,green production and consumption system construction,ecological environment restoration and municipal coordination.展开更多
Based on the requirements of local high-quality economic development and addressing the critical task of transformation and upgrading in the tea industry,this paper systematically discusses the necessity and feasibili...Based on the requirements of local high-quality economic development and addressing the critical task of transformation and upgrading in the tea industry,this paper systematically discusses the necessity and feasibility of constructing an optimal industrialization operation system driven by the dual wheels of"branding+standardization".The article first clarifies the connotation of high-quality development and the synergistic mechanism between branding and standardization.It then analyzes the current situation and bottlenecks of China's tea industry development.Subsequently,it proposes a dual-wheel drive strategy where branding enhances value and standardization guarantees quality,and designs a systematic implementation plan involving industrial chain synergy optimization and integrated support from government,industry,academia,research,and application.On this basis,strategies and suggestions are proposed,encompassing the starting point,standard focal points,key effort areas,innovation points,and target achievement points.The aim is to promote the tea industry to break through homogeneous competition,achieve value ascent,and provide important industrial support for regional high-quality development through the construction of the aforementioned system.展开更多
Agricultural land development is a pivotal strategy for addressing the global food security crisis.Barren grassland,especially those in mountainous regions,constitutes critical areas where cultivation can substantiall...Agricultural land development is a pivotal strategy for addressing the global food security crisis.Barren grassland,especially those in mountainous regions,constitutes critical areas where cultivation can substantially enhance land resources.This study highlights the necessity for a precise correlation between land development initiatives and constraints in order to optimize efficiency and enhance the effectiveness of such projects,with the core being the seamless integration of land development engineering and techniques to eliminate agricultural constraints.This study employs a systems engineering approach to classify improvement factors into mobile and fixed categories,elucidating the integration methods of constraint factors.Adhering to the Wooden Barrel Principle,these constraints were rigorously analyzed based on soil quality,land topography,water availability,and agricultural infrastructure.An innovative method of engineering type combination is proposed,which effectively explains the correlation between natural factors combination,project type combination,and target factors combination.It provides a convenient way for the selection of barren grassland development projects and lays a foundation for land planning,development project establishment,program selection,engineering design,and budget preparation.Taking Tang County of China as an example,it is divided into 19 factor improvement areas,a quick reference table of engineering types is established,and 14 main types of engineering combinations are obtained,which lays a foundation for the application of theoretical framework in practice.展开更多
The rapid expansion of urban development has led to the extensive construction of civil infrastructures.However,these urban development zones frequently face potential geohazards,primarily due to the lack of detailed ...The rapid expansion of urban development has led to the extensive construction of civil infrastructures.However,these urban development zones frequently face potential geohazards,primarily due to the lack of detailed site investigations and long-term monitoring of subsurface geological conditions.Understanding the temporal and spatial distributions of underground multi-field information is vital for successful engineering construction and effective utilization of urban underground space.In this study,a fiber optic nerve system(FONS)was utilized in the Tianfu New Area,Sichuan Province,China,to obtain comprehensive subsurface multi-physical information,including geological deformation,temperature,and surface hydrological data.The FONS incorporates three advanced fiber optic sensing techniques,i.e.fiber Bragg grating(FBG),Brillouin optical time domain reflectometry(BOTDR),and Raman optical time domain reflectometry(ROTDR).Fully-and quasi-distributed strain/temperature sensing cables have been installed in nine monitoring boreholes,covering various geological features such as plains,terraces,and areas within active fault zones.The field monitoring results confirm the feasibility of employing FONS for geological investigations within urban development zones,offering a valuable reference for future applications of this cost-effective technology in geohazard mitigation.展开更多
Ecosystems play a pivotal role in advancing Sustainable Development Goals(SDGs)by providing indispensable and resilient ecosystem services(ESs).However,the limited analysis of spatiotemporal heterogeneity often re str...Ecosystems play a pivotal role in advancing Sustainable Development Goals(SDGs)by providing indispensable and resilient ecosystem services(ESs).However,the limited analysis of spatiotemporal heterogeneity often re stricts the recognition of ESs’roles in attaining SDGs and landscape planning.We selected 183 counties in the Sichuan Province as the study area and mapped 10 SDGs and 7 ESs from 2000 to 2020.We used correlation analysis,principal component analysis,Geographically and Temporally Weighted Regression model,and self organizing maps to reveal the spatiotemporal heterogeneity of the impacts of the bundle of ESs on the SDGs and to develop spatial planning and management strategies.The results showed that(1)SDGs were improved in all counties,with SDG 1(No Poverty)and SDG 3(Good Health and Well-being)exhibiting poor performance.West ern Sichuan demonstrated stronger performance in environment-related SDGs in the Sichuan Province,while the Sichuan Basin showed better progress in socio-economic-related SDGs;(2)habitat quality,carbon sequestration,air pollution removal,and soil retention significantly influenced the development of 9 SDGs;(3)supporting,regulating,and provisioning service bundles have persistent and stable spatiotemporal heterogeneity effects on SDG1,SDG8,SDG11,SDG13,and SDG15.These findings substantiate the need for integrated management of multiple ESs and facilitate the regional achievement of SDGs in geographically intricate areas.展开更多
This paper highlights the critical role of medical device design and development documents within the quality system,including their compliance with regulatory standards,their function as a traceable record,their supp...This paper highlights the critical role of medical device design and development documents within the quality system,including their compliance with regulatory standards,their function as a traceable record,their support for all stages,and their use in risk and change management.It also covers document template creation,review record association,information management,adverse event traceability,and the reconciliation of differences in international declarations.展开更多
Ecosystem services in urban agglomerations are the environmental conditions under which human survival and development are sustained.Quantitative assessment of ecosystem services and complex interactions can contribut...Ecosystem services in urban agglomerations are the environmental conditions under which human survival and development are sustained.Quantitative assessment of ecosystem services and complex interactions can contribute positively to the achievement of the Sustainable Development Goals(SDGs)for urban agglomerations.However,studies on the future contribution of multi-scenario ecosystem services to the SDGS are lacking.We pronovel integrated modeling framework that integrates the CLUES,InVEST,SOM,and GWR approaches to address the complex relationship between ecosystem services over a long“past-present-future”time series.We construct a novel ecosystem service bundle-based approach for measuring urban agglomerations progress towards achieving ecologically relevant sustainable development goals at multiple scales.In the future scenario,the water yield(WY),habitat quality(HQ),and soil conservation(SC)show similar spatial patterns,with comparable spatial grids,while carbon stock(CS)remains predominantly unchanged and the ecological protection scenario(EPS)improves more significantly.The high-synergy regions are mainly distributed in bundle 4,and most of the trade-off regions appear in bundles 1 and 2.Over the last 30 years,all but the water-related SDGs are declining in bundle 1 of the two urban agglomerations,which are 15%higher in the Guangxi Beibu Gulf(GBG)than in the Guangdong-Hong Kong-Macao Greater Bay Area(GBA).From 2020 to 2035,the three scenarios demonstrate that the optimization of the SDGs progresses most effectively under the future ecological protection scenario(EPS).In particular,bundles 3 and 4 are significantly improved.This critical new knowledge can be used in sustainable ecosystem management and decision-making in urban agglomerations.展开更多
基金Supported by Guangxi Natural Science Fund Item in China ( Guikezi 0991023Z)
文摘[Objective] The research aimed to study design and development of system platform of 'study on relationship between natural phenology and climate change' based on WEB and GIS. [Method] Relied on the technologies of WEB and GIS, a set of system platform of 'study on relationship between natural phenology and climate change' was developed based on the hybrid architecture of C/S (Client/Server) and B/S (Browser/Server). Moreover, its establishing process and functional module were detailedly introduced. [Result] The natural phenology and climate change in Guangxi were research objects of system platform of 'study on relationship between natural phenology and climate change'. By combining WEB and GIS with database, the primary application of 'study on relationship between natural phenology and climate change' was realized. The system used hybrid architecture of C/S and B/S. The four-layer architectures were independent to improve security, stability and maintainability of system. The visual interface on the foreground was simply, clear and easy to use. The generating program of GIS three-dimensional graph on the background was real-time and high-efficiency, providing powerful guarantee for stable and safe operation of phenology research work process. The system had functions of inquiry, analysis, statistical diagram, GIS three-dimensional graph and data export. Through the analysis of natural phenology observation data, the system could find variation rule of natural phenology as three-dimensional space (longitude, latitude and altitude) and its relationship with climate change. [Conclusion] The research laid good foundation for further deeply carrying out application of 'study on relationship between natural phenology and climate change', and also provided reference basis for recognizing nature and using change rule of phenology to execute production scheduling and strategic decision (seed-introduction and regionalization).
基金supported by the National Key R&D Program of China,No.2019YFA0110300(to ZG)the National Natural Science Foundation of China,Nos.81773302(to YF),32070862(to ZG).
文摘Human brain development is a complex process,and animal models often have significant limitations.To address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and disease.To enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid culture.This involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid system.This cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology testing.As a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental toxins.Brain organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature differentiation.Cadmium exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic locations.The convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.
文摘To advance intelligent construction,standards must come first.The Ministry of Housing and Urban-Rural Development has issued the List for Replicable Experience and Practices for Developing Intelligent Construction four times successively and the Technical Guidelines for Intelligent Construction(Trial).
文摘Governance debates gained strong momentum in Africa in early December 2025 as the China-Kenya Readers Forum on Xi Jinping:The Governance of China convened in Nairobi on 1 December 2025,followed by a promotional event for the English edition of the book’s fifth volume on 3 December 2025 in Johannesburg,South Africa.
基金supported by Ministry of Science and Technology China Brain Initiative Grant,No.2022ZD0204702(to ZY)the National Natural Science Foundation of China,No.82371357(to LC)+2 种基金Foundation for Military Medicine,No.16QNP085(to ZY)Navy Medical University Basic Medical College“Yi Zhang”Basic Medical Talent Development and Support Program,Nos.JCYZRC-D-022(to TC)and JCYZRC-D-024(to HD)Science and Technology Innovation Special Fund of Shanghai Baoshan District,No.2023-E-05(to YW).
文摘Macrophages in the brain barrier system include microglia in the brain parenchyma,border-associated macrophages at the brain’s borders,and recruited macrophages.They are responsible for neural development,maintenance of homeostasis,and orchestrating immune responses.With the rapid exploitation and development of new technologies,there is a deeper understanding of macrophages in the brain barrier system.Here we review the origin,development,important molecules,and functions of macrophages,mainly focusing on microglia and border-associated macrophages.We also highlight some advances in single-cell sequencing and significant cell markers.We anticipate that more advanced methods will emerge to study resident and recruited macrophages in the future,opening new horizons for neuroimmunology and related peripheral immune fields.
基金supported by the National Nature Science Foundation of China(Grant No.31660568)Guangxi Science and Technology major project(Grant No.GuikeAA22068088)+2 种基金start-up funding for introduced talents in Guangxi University,the Guangxi Colleges and Universities Young and Middle-aged Teachers'Basic Scientific Research Ability Improvement Project(Grant No.2024KY0010)Guangxi Graduate Education Innovation Program(Grant No.YCSW2024093)the Guangxi University Student Innovation and Entrepreneurship Training Program Funding Project(Grant Nos.202310593704,202310593714,202410953044S).
文摘N6-methyladenosine(m^(6)A)modification,the most abundant internal modification in messenger RNA(mRNA)and long non-coding RNA(lncRNA),has emerged as a critical epitranscriptomic regulatory mechanism in eukaryotes.While the importance of m^(6)A modification in various biological processes has been recognized,a comprehensive understanding of its diverse roles in plant biology and agricultural applications remains fragmented.This review analyzes recent advances inm^(6)A modification's biological functions in plants.m^(6)A modification plays crucial roles in multiple aspects of plant life,including seed germination,organ development,and reproductive structure formation.Furthermore,m^(6)A has been found to significantly influence plant responses to environmental stresses,including salt,drought,temperature,and heavy metal exposure.We also uncover m^(6)A involvement in important agricultural traits.This review provides insights into the mechanistic understanding of m^(6)A modification in plants and highlights its applications in agricultural improvement,offering a foundation for future research in crop enhancement and stress resistance.
基金supported by the Center for Cognition and Sociality,Institute for Basic Science(IBS)(IBS-R001-D2)(to WK).
文摘The early developmental period is a critical window during which brain cells mature and contribute to both brain development and later life functions.Gamma-aminobutyric acid(GABA),recognized as a major neurotransmitter,plays a crucial role in coordinating synapse formation,neuronal proliferation,and migration during this time.
基金supported by the National Natural Science Foundation of China(Grant No.32160172)the Key Science-Technology Project of Inner Mongolia(2023KYPT0010)+1 种基金the Natural Science Foundation of Inner Mongolia Autonomous Region of China(Grant No.2025QN03006)the 2023 Inner Mongolia Public Institution High-Level Talent Introduction Scientific Research Support Project.
文摘Environmental DNA(eDNA)technology has revolutionized biodiversity monitoring with its non-invasive,sensitive,and cost-efficient approach.This paper systematically reviews eDNA advancements,examining its applications in aquatic and terrestrial ecosystems and assessing China’s standardization progress.It delineates four developmental phases from single-species detection to high-throughput sequencing,and highlights China’s contribution to the development of technical standards.While significant progress has been made,challenges persist in quantitative accuracy,methodological consistency,and large-scale implementation.Future efforts should prioritize enhanced standardization,improved quantification techniques,broader applications,and international collaboration to drive innovation in eDNA technology.
基金support through the“Trans-Disciplinary Research”Grant(No.R/Dev/IoE/TDRProjects/2023-24/61658),which played a crucial role in enabling this research endeavor.
文摘Floodplain wetlands are invaluable ecosystems providing numerous ecological benefits,yet they face a global crisis necessitating sustainable preservation efforts.This study examines the depletion of floodplain wetlands within the Hastinapur Wildlife Sanctuary(HWLS)in Uttar Pradesh.Encroachment activities such as grazing,agriculture,and human settlements have fragmented and degraded critical wetland ecosystems.Additionally,irrigation projects,dam construction,and water diversion have disrupted natural water flow and availability.To assess wetland inundation in 2023,five classification techniques were employed:Random Forest(RF),Support Vector Machine(SVM),artificial neural network(ANN),Spectral Information Divergence(SID),and Maximum Likelihood Classifier(MLC).SVM emerged as the most precise method,as determined by kappa coefficient and index-based validation.Consequently,the SVM classifier was used to model wetland inundation areas from 1983 to 2023 and analyze spatiotemporal changes and fragmentation patterns.The findings revealed that the SVM clas-sifier accurately mapped 2023 wetland areas.The modeled time-series data demonstrated a 62.55%and 38.12%reduction in inundated wetland areas over the past 40 years in the pre-and post-monsoon periods,respectively.Fragmentation analysis indicated an 86.27%decrease in large core wetland areas in the pre-monsoon period,signifying severe habitat degradation.This rapid decline in wetlands within protected areas raises concerns about their ecological impacts.By linking wetland loss to global sustainability objectives,this study underscores the global urgency for strengthened wetland protection measures and highlights the need for integrating wetland conservation into broader sustainable development goals.Effective policies and adaptive management strategies are crucial for preserving these ecosystems and their vital services,which are essential for biodiversity,climate regulation,and human well-being.
文摘This study examined the role of green energy development in mitigating climate change and fostering sustainable development in Central Asia including Kazakhstan,Uzbekistan,Kyrgyzstan,Tajikistan,and Turkmenistan.The region has substantial untapped potential in solar energy,wind energy,hydropower energy,as well as biomass and bioenergy,positioning it strategically for renewable energy deployment.The result demonstrated that integrating renewable energy can reduce greenhouse gas emissions,improve air quality,enhance energy security,and support rural development.Case studies from Kazakhstan,Uzbekistan,Kyrgyzstan,and Tajikistan showed measurable environmental and economic benefits.However,the large-scale use of renewable energy still faces numerous barriers,including outdated infrastructure,fragmented regulatory frameworks,limited investment,and shortages of technical expertise.Overcoming these obstacles requires institutional reform,stronger regional cooperation,and increasing engagement from international financial institutions and private investors.Modernizing grids,deploying storage systems,and investing in education,research,and innovation are critical for building human capacity in renewable energy sector.Accelerating the renewable energy transition is essential for Central Asia to meet climate goals,enhance environmental resilience,and ensure long-term socioeconomic development through innovation,investment,and regional collaboration.
文摘Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables this dynamic is the white matter(WM),known to be affected in neurodevelopmental disorders(NDDs)(Rokach et al.,2024).WM formation is mediated by myelination,a multifactorial process driven by neuro-glia interactions dependent on proper neuronal functionality(Simons and Trajkovic,2006).Another key aspect of neurodevelopmental abnormalities involves neuronal dynamics and function,with recent advances significantly enhancing our understanding of both neuronal and glial mitochondrial function(Devine and Kittler,2018;Rojas-Charry et al.,2021).Energy homeostasis in neurons,attributed largely to mitochondrial function,is critical for proper functionality and interactions with oligodendrocytes(OLs),the cells forming myelin in the brain’s WM.We herein discuss the interplay between these processes and speculate on potential dysfunction in NDDs.
基金the Strategic Research Plan of the Centre for Marine Technology and Ocean Engineering(CENTEC),which is financed by the Portuguese Foundation for Science and Technology(Fundação para a Ciência e a Tecnologia FCT)under contract UIDB/UIDP/00134/2020.
文摘This study examines the methods to plan the development of offshore oilfields over the years,which are used to support the decision-making on the development of offshore oilfields.About 100 papers are analysed and categorised into different groups of main early-stage decisions.The present study stands in contrast to the contributions of the operations research and system engineering review articles,on the one hand,and the petroleum engineering review articles,on the other.This is because it does not focus on one methodological approach,nor does it limit the literature analysis by offshore oilfield characteristics.Consequently,the present analysis may offer valuable insights,for instance,by identifying environmental planning decisions as a recent yet highly significant concern that is currently being imposed on decision-making process.Thus,it is evident that the incorporation of safety criteria within the technical-economic decision-making process for the design of production systems would be a crucial requirement at development phase.
基金support from Guangdong Science and Technology(20230505)Guangdong Provincial Philosophy and Social Science Planning Project(GD20SQ25)Guangdong Provincial Special Fund for Science and Technology Innovation Strategy in 2024(Cultivation of College Students’Science and Technology Innovation)(pdjh2024a391)during preparation of this manuscript.
文摘This study investigates the coordination between regional economic growth and ecological sustainability within the context of high-quality town economy development.To address the challenges of balancing economic expansion with environmental protection,a comprehensive evaluation index system is constructed,encompassing two key dimensions:regional economy and ecological environment.Using panel data from 2013 to 2022,the coupling coordination degree model is employed to quantify the interactions and synergy between these dimensions.Additionally,spatial econometric methods are applied to calculate both global and local Moran’s Index,revealing spatial clustering patterns,regional disparities,and heterogeneity.The relative development model further identifies critical factors influencing regional coordination,with a focus on the lagging development of basic infrastructure and public services.The findings demonstrate a positive temporal trend toward improved regional coordination and reduced development gaps,with a spatial pattern characterized by higher coupling degrees in eastern and central regions compared to western areas.Based on these results,this study proposes actionable strategies to enhance coordinated development,emphasizing ecological conservation,the establishment of green production and consumption systems,ecological restoration,and strengthened municipal collaboration.This revised abstract emphasizes the study’s purpose,methods,and key findings more clearly while maintaining a professional and concise tone.Finally,based on the above analysis results,the corresponding coordinated development suggestions of regional economy and ecological environment are given from the aspects of ecological environment protection measures,green production and consumption system construction,ecological environment restoration and municipal coordination.
基金Supported by General Project of Philosophy and Social Sciences Research in Universities of Jiangsu Province,2024(2024SJYB1650).
文摘Based on the requirements of local high-quality economic development and addressing the critical task of transformation and upgrading in the tea industry,this paper systematically discusses the necessity and feasibility of constructing an optimal industrialization operation system driven by the dual wheels of"branding+standardization".The article first clarifies the connotation of high-quality development and the synergistic mechanism between branding and standardization.It then analyzes the current situation and bottlenecks of China's tea industry development.Subsequently,it proposes a dual-wheel drive strategy where branding enhances value and standardization guarantees quality,and designs a systematic implementation plan involving industrial chain synergy optimization and integrated support from government,industry,academia,research,and application.On this basis,strategies and suggestions are proposed,encompassing the starting point,standard focal points,key effort areas,innovation points,and target achievement points.The aim is to promote the tea industry to break through homogeneous competition,achieve value ascent,and provide important industrial support for regional high-quality development through the construction of the aforementioned system.
基金funded by Science and Technology Project of Hebei Education Department[QN2023085].
文摘Agricultural land development is a pivotal strategy for addressing the global food security crisis.Barren grassland,especially those in mountainous regions,constitutes critical areas where cultivation can substantially enhance land resources.This study highlights the necessity for a precise correlation between land development initiatives and constraints in order to optimize efficiency and enhance the effectiveness of such projects,with the core being the seamless integration of land development engineering and techniques to eliminate agricultural constraints.This study employs a systems engineering approach to classify improvement factors into mobile and fixed categories,elucidating the integration methods of constraint factors.Adhering to the Wooden Barrel Principle,these constraints were rigorously analyzed based on soil quality,land topography,water availability,and agricultural infrastructure.An innovative method of engineering type combination is proposed,which effectively explains the correlation between natural factors combination,project type combination,and target factors combination.It provides a convenient way for the selection of barren grassland development projects and lays a foundation for land planning,development project establishment,program selection,engineering design,and budget preparation.Taking Tang County of China as an example,it is divided into 19 factor improvement areas,a quick reference table of engineering types is established,and 14 main types of engineering combinations are obtained,which lays a foundation for the application of theoretical framework in practice.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.42225702 and 42077235).
文摘The rapid expansion of urban development has led to the extensive construction of civil infrastructures.However,these urban development zones frequently face potential geohazards,primarily due to the lack of detailed site investigations and long-term monitoring of subsurface geological conditions.Understanding the temporal and spatial distributions of underground multi-field information is vital for successful engineering construction and effective utilization of urban underground space.In this study,a fiber optic nerve system(FONS)was utilized in the Tianfu New Area,Sichuan Province,China,to obtain comprehensive subsurface multi-physical information,including geological deformation,temperature,and surface hydrological data.The FONS incorporates three advanced fiber optic sensing techniques,i.e.fiber Bragg grating(FBG),Brillouin optical time domain reflectometry(BOTDR),and Raman optical time domain reflectometry(ROTDR).Fully-and quasi-distributed strain/temperature sensing cables have been installed in nine monitoring boreholes,covering various geological features such as plains,terraces,and areas within active fault zones.The field monitoring results confirm the feasibility of employing FONS for geological investigations within urban development zones,offering a valuable reference for future applications of this cost-effective technology in geohazard mitigation.
基金supported by the Second Tibetan Plateau Scien-tific Expedition and Research Program(STEP)of China(Grant No.2019QZKK0402).
文摘Ecosystems play a pivotal role in advancing Sustainable Development Goals(SDGs)by providing indispensable and resilient ecosystem services(ESs).However,the limited analysis of spatiotemporal heterogeneity often re stricts the recognition of ESs’roles in attaining SDGs and landscape planning.We selected 183 counties in the Sichuan Province as the study area and mapped 10 SDGs and 7 ESs from 2000 to 2020.We used correlation analysis,principal component analysis,Geographically and Temporally Weighted Regression model,and self organizing maps to reveal the spatiotemporal heterogeneity of the impacts of the bundle of ESs on the SDGs and to develop spatial planning and management strategies.The results showed that(1)SDGs were improved in all counties,with SDG 1(No Poverty)and SDG 3(Good Health and Well-being)exhibiting poor performance.West ern Sichuan demonstrated stronger performance in environment-related SDGs in the Sichuan Province,while the Sichuan Basin showed better progress in socio-economic-related SDGs;(2)habitat quality,carbon sequestration,air pollution removal,and soil retention significantly influenced the development of 9 SDGs;(3)supporting,regulating,and provisioning service bundles have persistent and stable spatiotemporal heterogeneity effects on SDG1,SDG8,SDG11,SDG13,and SDG15.These findings substantiate the need for integrated management of multiple ESs and facilitate the regional achievement of SDGs in geographically intricate areas.
文摘This paper highlights the critical role of medical device design and development documents within the quality system,including their compliance with regulatory standards,their function as a traceable record,their support for all stages,and their use in risk and change management.It also covers document template creation,review record association,information management,adverse event traceability,and the reconciliation of differences in international declarations.
基金National Natural Science Foundation of China,No.U21A2022,No.U1901219,No.42071393,No.42101369。
文摘Ecosystem services in urban agglomerations are the environmental conditions under which human survival and development are sustained.Quantitative assessment of ecosystem services and complex interactions can contribute positively to the achievement of the Sustainable Development Goals(SDGs)for urban agglomerations.However,studies on the future contribution of multi-scenario ecosystem services to the SDGS are lacking.We pronovel integrated modeling framework that integrates the CLUES,InVEST,SOM,and GWR approaches to address the complex relationship between ecosystem services over a long“past-present-future”time series.We construct a novel ecosystem service bundle-based approach for measuring urban agglomerations progress towards achieving ecologically relevant sustainable development goals at multiple scales.In the future scenario,the water yield(WY),habitat quality(HQ),and soil conservation(SC)show similar spatial patterns,with comparable spatial grids,while carbon stock(CS)remains predominantly unchanged and the ecological protection scenario(EPS)improves more significantly.The high-synergy regions are mainly distributed in bundle 4,and most of the trade-off regions appear in bundles 1 and 2.Over the last 30 years,all but the water-related SDGs are declining in bundle 1 of the two urban agglomerations,which are 15%higher in the Guangxi Beibu Gulf(GBG)than in the Guangdong-Hong Kong-Macao Greater Bay Area(GBA).From 2020 to 2035,the three scenarios demonstrate that the optimization of the SDGs progresses most effectively under the future ecological protection scenario(EPS).In particular,bundles 3 and 4 are significantly improved.This critical new knowledge can be used in sustainable ecosystem management and decision-making in urban agglomerations.
