Objective:To explore the risk factors for the progression of renal function deterioration in patients with diabetic nephropathy(DN).Methods:The clinical data and biochemical indexes of 100 diabetic patients admitted t...Objective:To explore the risk factors for the progression of renal function deterioration in patients with diabetic nephropathy(DN).Methods:The clinical data and biochemical indexes of 100 diabetic patients admitted to our hospital from October 2021 to October 2022 were retrospectively analyzed.The patients were divided into a DN group,which consisted of 55 cases,and a nondiabetic nephropathy group(NDN),which consisted of 45 cases.The urinary microalbumin to creatinine ratio,the clinical data(gender,age,duration of the disease,and BMI),and the biochemical indexes(triglycerides[TG],low-density lipoprotein cholesterol[LDL-C],high-density lipoprotein cholesterol[HDL-C],total cholesterol[TC],glycated hemoglobin A1c[HbA1c],systolic blood pressure[SBP],diastolic blood pressure[DBP])of the two groups were compared.Subsequently,the risk factors related to the progression of renal function deterioration in DN were analyzed through multifactorial logistic regression analysis.Results:No statistically significant difference was observed in the comparison of gender,age,BMI,LDL-C,and DBP between the two groups(P>0.05).The DN group demonstrated a longer disease duration and higher SBP,TC,HDL-C,HbA1c,and TG compared to the NDN group(P<0.05).Through multifactorial logistic regression analysis,it was found that the duration of the disease,the TC,the HDL-C,the HbA1c,the TG,and the SBP were independent risk factors of the deterioration of renal function in DN patients.Conclusion:Other than conventional indicators,TC,HDL-C,HbA1c,TG,and SBP are also crucial indicators in determining the progression of renal function deterioration in DN patients.展开更多
Alzheimer’s disease(AD)is a slow,progressive neurodegenerative disease with clinical symptoms that typically emerge in the elderly,leading to deterioration of cognitive functions over time.Memory loss is the primary ...Alzheimer’s disease(AD)is a slow,progressive neurodegenerative disease with clinical symptoms that typically emerge in the elderly,leading to deterioration of cognitive functions over time.Memory loss is the primary symptom,eventually leading to significant declines in executive and cognitive functions,along with psychiatric and behavioral changes,and alterations in personality.展开更多
Neuropathologies include the deterioration and damage of the nervous system,especially neurons present in the brain,spinal cord and peripheral nervous system.Damage or alternations in neurons makes their structure and...Neuropathologies include the deterioration and damage of the nervous system,especially neurons present in the brain,spinal cord and peripheral nervous system.Damage or alternations in neurons makes their structure and functionality abnormal.Every year over 90,000 people get affected by neurodegenerative diseases in the USA.Among all the neurological pathologies,展开更多
Acute-on-chronic liver failure(ACLF)is a complex clinical syndrome characterized by high 28-day and 90-day mortality rates,ranging from 13%to 93%,resulting from the acute deterioration of liver function in patients wi...Acute-on-chronic liver failure(ACLF)is a complex clinical syndrome characterized by high 28-day and 90-day mortality rates,ranging from 13%to 93%,resulting from the acute deterioration of liver function in patients with chronic liver disease.Transplantation of umbilical cord-derived mesenchymal stem cells(UC-MSCs)at different cell dosages has been shown to improve hepatic function in patients with decompensated cirrhosis or ACLF.[1,2]Notably,most clinical studies to date have used freshly prepared MSCs.This trial aimed to evaluate the tolerability,safety,and efficiency of off-the-shelf UC-MSC products in patients with ACLF.展开更多
Background:Language impairment is relatively common in Parkinson’s disease(PD),but not all PD patients are susceptible to language problems.In this study,we identified among a sample of PD patients those pre-disposed...Background:Language impairment is relatively common in Parkinson’s disease(PD),but not all PD patients are susceptible to language problems.In this study,we identified among a sample of PD patients those pre-disposed to language impairment,describe their clinical profiles,and consider factors that may precipitate language disability in these patients.Methods:A cross-sectional cohort of 31 PD patients and 20 controls were administered the Chinese version of the Western Aphasia Battery(WAB)to assess language abilities,and the Montreal Cognitive Assessment(MoCA)to determine cognitive status.PD patients were then apportioned to a language-impaired PD(LI-PD)group or a PD group with no language impairment(NLI-PD).Performance on the WAB and MoCA was investigated for correlation with the aphasia quotient deterioration rate(AQDR).Results:The PD patients scored significantly lower on most of the WAB subtests than did the controls.The aphasia quotient,cortical quotient,and spontaneous speech and naming subtests of the WAB were significantly different between LI-PD and NLI-PD groups.The AQDR scores significantly and positively correlated with age at onset and motor function deterioration.Conclusion:A subset group was susceptible to language dysfunction,a major deficit in spontaneous speech.Once established,dysphasia progression is closely associated with age at onset and motor disability progression.展开更多
文摘Objective:To explore the risk factors for the progression of renal function deterioration in patients with diabetic nephropathy(DN).Methods:The clinical data and biochemical indexes of 100 diabetic patients admitted to our hospital from October 2021 to October 2022 were retrospectively analyzed.The patients were divided into a DN group,which consisted of 55 cases,and a nondiabetic nephropathy group(NDN),which consisted of 45 cases.The urinary microalbumin to creatinine ratio,the clinical data(gender,age,duration of the disease,and BMI),and the biochemical indexes(triglycerides[TG],low-density lipoprotein cholesterol[LDL-C],high-density lipoprotein cholesterol[HDL-C],total cholesterol[TC],glycated hemoglobin A1c[HbA1c],systolic blood pressure[SBP],diastolic blood pressure[DBP])of the two groups were compared.Subsequently,the risk factors related to the progression of renal function deterioration in DN were analyzed through multifactorial logistic regression analysis.Results:No statistically significant difference was observed in the comparison of gender,age,BMI,LDL-C,and DBP between the two groups(P>0.05).The DN group demonstrated a longer disease duration and higher SBP,TC,HDL-C,HbA1c,and TG compared to the NDN group(P<0.05).Through multifactorial logistic regression analysis,it was found that the duration of the disease,the TC,the HDL-C,the HbA1c,the TG,and the SBP were independent risk factors of the deterioration of renal function in DN patients.Conclusion:Other than conventional indicators,TC,HDL-C,HbA1c,TG,and SBP are also crucial indicators in determining the progression of renal function deterioration in DN patients.
基金supported by the National Natural Science Foundation of China(82120108010 and 81930028).
文摘Alzheimer’s disease(AD)is a slow,progressive neurodegenerative disease with clinical symptoms that typically emerge in the elderly,leading to deterioration of cognitive functions over time.Memory loss is the primary symptom,eventually leading to significant declines in executive and cognitive functions,along with psychiatric and behavioral changes,and alterations in personality.
文摘Neuropathologies include the deterioration and damage of the nervous system,especially neurons present in the brain,spinal cord and peripheral nervous system.Damage or alternations in neurons makes their structure and functionality abnormal.Every year over 90,000 people get affected by neurodegenerative diseases in the USA.Among all the neurological pathologies,
基金supported by grants from the National Key Research and Development Program of China(No.2020YFA0710804)Key Research and Development Program of Shaanxi(No.2023ZDLSF-34)Clinical Research Project of Air Force Military Medical University(Nos.2021LC2105 and 2023LC2311).
文摘Acute-on-chronic liver failure(ACLF)is a complex clinical syndrome characterized by high 28-day and 90-day mortality rates,ranging from 13%to 93%,resulting from the acute deterioration of liver function in patients with chronic liver disease.Transplantation of umbilical cord-derived mesenchymal stem cells(UC-MSCs)at different cell dosages has been shown to improve hepatic function in patients with decompensated cirrhosis or ACLF.[1,2]Notably,most clinical studies to date have used freshly prepared MSCs.This trial aimed to evaluate the tolerability,safety,and efficiency of off-the-shelf UC-MSC products in patients with ACLF.
基金by the China National Nature Science Fund(No.30973153No.81371421)+2 种基金the Foundation of the Liaoning Educational Committee(L202013136 and L2010560)Liaoning Doctoral Starting Fund(20071042)the Liaoning S&T project Fund(2011225020).
文摘Background:Language impairment is relatively common in Parkinson’s disease(PD),but not all PD patients are susceptible to language problems.In this study,we identified among a sample of PD patients those pre-disposed to language impairment,describe their clinical profiles,and consider factors that may precipitate language disability in these patients.Methods:A cross-sectional cohort of 31 PD patients and 20 controls were administered the Chinese version of the Western Aphasia Battery(WAB)to assess language abilities,and the Montreal Cognitive Assessment(MoCA)to determine cognitive status.PD patients were then apportioned to a language-impaired PD(LI-PD)group or a PD group with no language impairment(NLI-PD).Performance on the WAB and MoCA was investigated for correlation with the aphasia quotient deterioration rate(AQDR).Results:The PD patients scored significantly lower on most of the WAB subtests than did the controls.The aphasia quotient,cortical quotient,and spontaneous speech and naming subtests of the WAB were significantly different between LI-PD and NLI-PD groups.The AQDR scores significantly and positively correlated with age at onset and motor function deterioration.Conclusion:A subset group was susceptible to language dysfunction,a major deficit in spontaneous speech.Once established,dysphasia progression is closely associated with age at onset and motor disability progression.
