In recent decades,many software reliability growth models（SRGMs） have been proposed for the engineers and testers in measuring the software reliability precisely.Most of them is established based on the non-homogene...In recent decades,many software reliability growth models（SRGMs） have been proposed for the engineers and testers in measuring the software reliability precisely.Most of them is established based on the non-homogeneous Poisson process（NHPP）,and it is proved that the prediction accuracy of such models could be improved by adding the describing of characterization of testing effort.However,some research work indicates that the fault detection rate（FDR） is another key factor affects final software quality.Most early NHPPbased models deal with the FDR as constant or piecewise function,which does not fit the different testing stages well.Thus,this paper first incorporates a multivariate function of FDR,which is bathtub-shaped,into the NHPP-based SRGMs considering testing effort in order to further improve performance.A new model framework is proposed,and a stepwise method is used to apply the framework with real data sets to find the optimal model.Experimental studies show that the obtained new model can provide better performance of fitting and prediction compared with other traditional SRGMs.展开更多
At present,many researchers focused on the point-of-care testing（POCT）,a method of disease markers detection without large-scale instruments and specialized persons.However,most POCT diagnostic methods were suffered...At present,many researchers focused on the point-of-care testing（POCT）,a method of disease markers detection without large-scale instruments and specialized persons.However,most POCT diagnostic methods were suffered from poor detection sensitivity or inefficiency in quantitative detection.Herein,we developed a newly QD-immune fluorescence test strips（QD-IFTS） based on quantum dots（QDs） as the fluorescence nanocarrier to prepare the immune fluorescence probes in the classical immunochromatography detection system for sensing carcino-embryonic antigen（CEA）,a kind of glycoprotein produced by intestinal tissue and a broad spectrum of tumor marker for cancer diagnosis.And we designed a homemade strips fluorescence reader for detection of fluorescence intensity of QDs on the QD-IFTS.Under the optimized reaction conditions,chromatographic time of the newly QD-IFTS was only25 min,sample volume of the newly QD-IFTS was only 40 m L and the LOD of the newly QD-IFTS was 0.72 ng/m L.In addition,the efficiency and robustness of the newly QD-IFTS were confirmed by successfully application in 300 clinical serum samples,and the results revealed great potential in clinical POCT of other biomarkers.展开更多
The construction investment of highway asphalt pavement is large and has a wide social impact. How to strictly control the construction quality through scientific and efficient field test and detection technology is a...The construction investment of highway asphalt pavement is large and has a wide social impact. How to strictly control the construction quality through scientific and efficient field test and detection technology is a very important link in the construction process and completion acceptance evaluation, which directly affects the construction schedule and service life of the pavement.Asphalt pavement detection technology is also an important representative of the scientific and technological level of equipment in the whole highway industry. It is the goal to reflect the objective performance efficiently and accurately.Therefore, this paper analyzes and discusses the on-site test and detection technology of highway asphalt pavement construction, hoping to promote the improvement of highway asphalt pavement construction quality.展开更多
The road traffic industry in China has been developing rapidly in recent years.Asphalt has become the main material in road construction because of its seamless connection and short construction period,and it has an i...The road traffic industry in China has been developing rapidly in recent years.Asphalt has become the main material in road construction because of its seamless connection and short construction period,and it has an important impact on the overall quality of highway construction.Therefore,it is necessary to conduct scientific and reasonable tests and detections for highway asphalt pavement.This paper presents a discussion on the test and detection technology of highway asphalt pavement for future reference.展开更多
Objective:Serological tests are widely used for scrub typhus diagnosis;however,their limitations are evident.This study aims to assess their practical value in clinical settings.Methods:We analyzed the data of adult p...Objective:Serological tests are widely used for scrub typhus diagnosis;however,their limitations are evident.This study aims to assess their practical value in clinical settings.Methods:We analyzed the data of adult patients with suspected scrub typhus who visited a tertiary care hospital in the Republic of Korea from September to December from 2019 to 2021.The included patients had an acute fever and at least one of the following ten secondary findings:myalgia,skin rash,eschar,headache,thrombocytopenia,increased liver enzyme levels,lymphadenopathy,hepatomegaly,splenomegaly,and pleural effusion.The diagnoses were grouped as scrub typhus or other diseases by two infectious disease physicians.Results:Among 136 patients who met the eligibility criteria,109 had scrub typhus and 27 had different diseases.Single and paired total antibodies using immunofluorescence assay(IFA),and total antibodies using immunochromatography-based rapid diagnostic testing(ICT)were measured in 98%,22%,and 75%of all patients,respectively.Confirmation using paired samples for scrub typhus was established at a median of 11[interquartile range(IQR)10-16]days following the first visit.Among the 82 admitted patients,the median admission time was 9(IQR 7-13)days.According to IFA,58(55%)patients with scrub typhus had total immunoglobulin titers≥1:320,while 23(85%)patients with other disease had titers<1:320.Positive ICT results were observed in 64(74%)patients with scrub typhus and 10(67%)patients with other diseases showed negative ICT results.Conclusions:Serological testing for scrub typhus is currently insufficient for decision-making in clinical practice.展开更多
Based on radon gas properties and its existing projects applications, we firstly attempted to apply geo- physical and chemical properties of radon gas in the field of mining engineering, and imported radioac- tive mea...Based on radon gas properties and its existing projects applications, we firstly attempted to apply geo- physical and chemical properties of radon gas in the field of mining engineering, and imported radioac- tive measurement method to detect the development process of the overlying strata mining-induced fractures and their contained water quality in underground coal mining, which not only innovates a more simple-fast-reliable detection method, but also further expands the applications of radon gas detection technology in mining field. A 3D simulation design of comprehensive testing system for detecting strata mining-induced fractures on surface with radon gas (CTSR) was carried out by using a large-scale 3D solid model design software Pro/Engineer (Pro/E), which overcame three main disadvantages of ''static design thought, 2D planar design and heavy workload for remodification design'' on exiting design for mining engineering test systems. Meanwhile, based on the simulation design results of Pro/E software, the sta- bility of the jack-screw pressure bar for the key component in CTSR was checked with a material mechan- ics theory, which provided a reliable basis for materials selection during the latter machining process.展开更多
Ⅰ The Indexes of Detecting Oil and Gas Resources The deeply buried reservoir which in a dynamic equilibrium state has a great pressure inside, and between it and earth surface there is a great difference of pressure....Ⅰ The Indexes of Detecting Oil and Gas Resources The deeply buried reservoir which in a dynamic equilibrium state has a great pressure inside, and between it and earth surface there is a great difference of pressure. Therefore the hydrocarbon must spread and move vertically to the surface along the pressure gradient orientation. Hydrocarbons in the reservoir along some small rifts, cracks, joints and cleavages penetrate the overlying strata and seepage onto the surface. Thus the hydrocarbons become unvisble oil and gas signs. This process is called the phenomena of hydrocarbon microseepage of reservoir. Hydrocarbons microseepage in the process展开更多
The implementation of expressway project construction and project management requires a full understanding of the importance of carrying out inspection activities and implementation, and the full implementation of thi...The implementation of expressway project construction and project management requires a full understanding of the importance of carrying out inspection activities and implementation, and the full implementation of this work. Carry out measurement hoisting, laboratory inspection, quality control during construction and test inspection before acceptance of materials before construction to ensure the implementation of test and inspection work, ensure the quality and benefit of highway engineering projects, and reduce hidden dangers and risks and problems during construction to effectively play its value and role. It is also necessary to recognize the professionalism and complexity of the implementation of relevant tasks, pay attention to strengthening the work in this area, improve the professional skills and comprehensive quality of inspectors, standardize the inspection process, and effectively improve the inspection level and performance.展开更多
With the construction of roads, China's economic and social development is faster and faster, and road construction in economic development is also more and more important, therefore, countries will focus on road ...With the construction of roads, China's economic and social development is faster and faster, and road construction in economic development is also more and more important, therefore, countries will focus on road construction. In the process of highway construction, test and inspection is an important measure to guarantee highway quality and improve the economic benefit of highway construction. From the current situation of our country, the highway test management level is not high. Therefore, based on the highway test management, this paper first states the importance of the highway test management, and then puts forward relevant solutions to improve the management level. In this hope to help the relevant construction units, and then improve their management level, to ensure the quality of highway.展开更多
Highway engineering testing is an important part of highway engineering technology management, the results of which determine whether the quality of highway engineering is qualified, whether it can be accepted and suc...Highway engineering testing is an important part of highway engineering technology management, the results of which determine whether the quality of highway engineering is qualified, whether it can be accepted and successfully implemented after the completion of the project. With the improvement of the scale and level of highway construction in China, the development of highway engineering test and test has not kept pace with the development of highway construction industry, and some problems have gradually become prominent in the work. This paper introduces the importance and necessity of highway engineering test, finds out the common problems and puts forward the solutions.展开更多
In recent years,the scale of China’s highway projects have been expanding.However,in real life,road construction projects in some places have not passed professional and rigorous inspections,resulting in various qual...In recent years,the scale of China’s highway projects have been expanding.However,in real life,road construction projects in some places have not passed professional and rigorous inspections,resulting in various quality problems,and seriously affecting the safety of drivers and pedestrians.This paper analyzes the current situation of highway engineering test and detection,expounds the application of new technologies for highway engineering test and detection.In this paper,a case study was carried out on ground penetrating radar(GPR),which aims to improve highway engineering test and detection and provide reference for reducing highway safety risks.展开更多
China in the actual development process of the basic engineering construction invested huge human and material resources, and perfect the basic engineering also laid a solid foundation for the rapid economic developme...China in the actual development process of the basic engineering construction invested huge human and material resources, and perfect the basic engineering also laid a solid foundation for the rapid economic development of China, which shows the important role of highway traffic engineering in the practical application process. For this reason, China has been strengthening the quality control of highway traffic engineering, through the establishment of a strict test testing system to control the quality of highway traffic engineering construction. Based on this, this paper will summarize the significance of engineering test and test, focus on the analysis of test and test technology key points and put forward the optimization of engineering test and test measures, hope to provide reference for relevant staff.展开更多
California Bearing Ratio(CBR)test is highly professional and requires a high level of skills.In order to improve the accuracy of the test results,the relevant staff will not only need to understand the rules and proce...California Bearing Ratio(CBR)test is highly professional and requires a high level of skills.In order to improve the accuracy of the test results,the relevant staff will not only need to understand the rules and procedures involved in the test,they would also need to be meticulous in their work to avoid human errors,provide good data support for highway engineering,and improve the overall quality of the project.Therefore,this paper presents an analysis of the application of CBR test in highway engineering,which can provide reference for engineering and promote the development of the highway industry.展开更多
This paper deals with the problem of detecting a signal whose amplitude is a scaling factor in the presence of homogeneous Gaussian noise with unknown covariance matrix.Since no uniformly most powerful test exists for...This paper deals with the problem of detecting a signal whose amplitude is a scaling factor in the presence of homogeneous Gaussian noise with unknown covariance matrix.Since no uniformly most powerful test exists for the problem at hand,we devise and assess a detection strategy based on the well-known Durbin test design criteria.The closed-form expressions for the probabilities of false alarm and detection of the Durbin test are derived,which show that it bears a constant false alarm rate property against the noise covariance matrix.At the analysis stage,the performance of the new receiver is assessed,also in comparison with some classical adaptive detectors,both in matched and in mismatched signal cases.The results show that the proposed detector achieves a visible performance improvement in the presence of severe steering vector mismatch,while maintaining an acceptable detection loss for matched signal.展开更多
To generate test vector sets that can efficiently activate hardware Trojans and improve probability of the hardware Trojan activation,an efficient hardware Trojan activation method is proposed based on greedy algorith...To generate test vector sets that can efficiently activate hardware Trojans and improve probability of the hardware Trojan activation,an efficient hardware Trojan activation method is proposed based on greedy algorithm for combinatorial hardware Trojans. Based on the greedy algorithm and the recursive construction method in the combination test,the method formulates appropriate and useful greedy strategy and generates test vector sets with different combinatorial correlation coefficients to activate hardware Trojans in target circuits. The experiment was carried out based on advanced encryption standard（ AES） hardware encryption circuit,different combinatorial hardware Trojans were implanted in AES as target circuits,the experiment of detecting hardware Trojans in target circuits was performed by applying the proposed method and different combinatorial hardware Trojans in target circuits were activated successfully many times in the experiment. The experimental results showthat the test vector sets generated using the proposed method could effectively activate combinatorial hardware Trojans,improve the probability of the hardware Trojan being activated,and also be applied to practice.展开更多
In cancer cells,higher reactive oxygen species(ROS)than normal cells were observed due to hypermetabolism.The redox balance in cancer cells relies on accordingly upregulated antioxidant capacity.By manipulating oxidat...In cancer cells,higher reactive oxygen species(ROS)than normal cells were observed due to hypermetabolism.The redox balance in cancer cells relies on accordingly upregulated antioxidant capacity.By manipulating oxidation and antioxidant systems,chemotherapeutic drugs can selectively kill cancer cells without hurting normal cells.As threedimensional(3D)in vitro models,such as spheroids and organoids,have become widely used in cancer research,traditional detection methods(e.g.,absorption tests or titration)are inadequate for detecting in 3D environments.Thus,it is crucial to find a new method to detect oxidative stress of 3D in vitro cancer models.Here,a nanocomposite electrochemical biosensor was exploited to evaluate oxidative stress of cancer cells cultured in the 3D environment.The oxidation-regulatory capacity of honokiol,a Magnolia genus-derived anti-cancer molecule,was evaluated.A screen-printed electrode(SPCE)was modified with reduced graphene oxide(RGO)and platinum nanoparticles(Pt NPs)to get Pt NPs/RGO/SPCE.Then the gelatin methacrylate/reduced graphene oxide(GelMA/RGO)hydrogel was applied to immobilized NCI-H1975 in a 3D bionic environment to get NCI-H1975/GelMA/RGO/Pt NPs/RGO/SPCE.After optimizing the experiment condition,the Pt NPs/RGO/SPCE showed a detection threshold of 0.65μM and a linear field from 1 to 10μM for H_(2)O_(2)detection while the NCI-H1975/GelMA/RGO/Pt NPs/RGO/SPCE sensitively responded to H_(2)O_(2)-induced oxidative stress.By utilizing the NCI-H1975/GelMA/RGO/Pt NPs/RGO/SPCE we found honokiol(a natural polyphenol constituent)inhibits NCI-H1975 by inducing oxidative stress.This simple cell-based electrochemical biosensor can in situ evaluate oxidative stress of 3D cancer models conveniently.It can also be easily extended to the study of the mechanism of action of other drugs and holds broad application prospects in the fields of new drug development and drug repurposing.展开更多
A superconducting solenoid prototype magnet for Accelerator Driven Snbcritical System（ADS） Injection I has been designed and fabricated,which has also been tested in a liquid Helium state inside a vertical Dewar in ...A superconducting solenoid prototype magnet for Accelerator Driven Snbcritical System（ADS） Injection I has been designed and fabricated,which has also been tested in a liquid Helium state inside a vertical Dewar in the Haerbin institute of Technology in November 2012.The design current was 210 A.when the test current reached400 A no quench occurred so the solenoid magnet was forced to quench by the embedded heaters.The integral field strength,leakage held at the nearby upstream and downstream superconducting spoke cavities all meet the design requirements.At the same time,it also checked the reliability of the vertical test Dewar and the quenched detection system.The superconducting prototype magnet has accumulated valuable experiences for the coming batch magnets production and cryogenic test.展开更多
基金supported by the National Natural Science Foundation of China(61070220)the Anhui Provincial Natural Science Foundation(1408085MKL79)
文摘In recent decades,many software reliability growth models（SRGMs） have been proposed for the engineers and testers in measuring the software reliability precisely.Most of them is established based on the non-homogeneous Poisson process（NHPP）,and it is proved that the prediction accuracy of such models could be improved by adding the describing of characterization of testing effort.However,some research work indicates that the fault detection rate（FDR） is another key factor affects final software quality.Most early NHPPbased models deal with the FDR as constant or piecewise function,which does not fit the different testing stages well.Thus,this paper first incorporates a multivariate function of FDR,which is bathtub-shaped,into the NHPP-based SRGMs considering testing effort in order to further improve performance.A new model framework is proposed,and a stepwise method is used to apply the framework with real data sets to find the optimal model.Experimental studies show that the obtained new model can provide better performance of fitting and prediction compared with other traditional SRGMs.
基金financially supported by the National Natural Science Foundation of China(Nos.51373117,51303126 and 31600800)Tianjin Natural Science and Technology Foundation(No.16ZXMJSY00010)
文摘At present,many researchers focused on the point-of-care testing（POCT）,a method of disease markers detection without large-scale instruments and specialized persons.However,most POCT diagnostic methods were suffered from poor detection sensitivity or inefficiency in quantitative detection.Herein,we developed a newly QD-immune fluorescence test strips（QD-IFTS） based on quantum dots（QDs） as the fluorescence nanocarrier to prepare the immune fluorescence probes in the classical immunochromatography detection system for sensing carcino-embryonic antigen（CEA）,a kind of glycoprotein produced by intestinal tissue and a broad spectrum of tumor marker for cancer diagnosis.And we designed a homemade strips fluorescence reader for detection of fluorescence intensity of QDs on the QD-IFTS.Under the optimized reaction conditions,chromatographic time of the newly QD-IFTS was only25 min,sample volume of the newly QD-IFTS was only 40 m L and the LOD of the newly QD-IFTS was 0.72 ng/m L.In addition,the efficiency and robustness of the newly QD-IFTS were confirmed by successfully application in 300 clinical serum samples,and the results revealed great potential in clinical POCT of other biomarkers.
文摘The construction investment of highway asphalt pavement is large and has a wide social impact. How to strictly control the construction quality through scientific and efficient field test and detection technology is a very important link in the construction process and completion acceptance evaluation, which directly affects the construction schedule and service life of the pavement.Asphalt pavement detection technology is also an important representative of the scientific and technological level of equipment in the whole highway industry. It is the goal to reflect the objective performance efficiently and accurately.Therefore, this paper analyzes and discusses the on-site test and detection technology of highway asphalt pavement construction, hoping to promote the improvement of highway asphalt pavement construction quality.
文摘The road traffic industry in China has been developing rapidly in recent years.Asphalt has become the main material in road construction because of its seamless connection and short construction period,and it has an important impact on the overall quality of highway construction.Therefore,it is necessary to conduct scientific and reasonable tests and detections for highway asphalt pavement.This paper presents a discussion on the test and detection technology of highway asphalt pavement for future reference.
基金the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI),funded by the Ministry of Health&Welfare,Republic of Korea(grant no.HI22C0306).
文摘Objective:Serological tests are widely used for scrub typhus diagnosis;however,their limitations are evident.This study aims to assess their practical value in clinical settings.Methods:We analyzed the data of adult patients with suspected scrub typhus who visited a tertiary care hospital in the Republic of Korea from September to December from 2019 to 2021.The included patients had an acute fever and at least one of the following ten secondary findings:myalgia,skin rash,eschar,headache,thrombocytopenia,increased liver enzyme levels,lymphadenopathy,hepatomegaly,splenomegaly,and pleural effusion.The diagnoses were grouped as scrub typhus or other diseases by two infectious disease physicians.Results:Among 136 patients who met the eligibility criteria,109 had scrub typhus and 27 had different diseases.Single and paired total antibodies using immunofluorescence assay(IFA),and total antibodies using immunochromatography-based rapid diagnostic testing(ICT)were measured in 98%,22%,and 75%of all patients,respectively.Confirmation using paired samples for scrub typhus was established at a median of 11[interquartile range(IQR)10-16]days following the first visit.Among the 82 admitted patients,the median admission time was 9(IQR 7-13)days.According to IFA,58(55%)patients with scrub typhus had total immunoglobulin titers≥1:320,while 23(85%)patients with other disease had titers<1:320.Positive ICT results were observed in 64(74%)patients with scrub typhus and 10(67%)patients with other diseases showed negative ICT results.Conclusions:Serological testing for scrub typhus is currently insufficient for decision-making in clinical practice.
基金support for this work provided by the Fundamental Research Funds for the Central Universities(China University of Mining & Technology) (No. 2010ZDP02B02)the State Key Laboratory of Coal Resources and Safe Mining(No. SKLCRSM08X02)
文摘Based on radon gas properties and its existing projects applications, we firstly attempted to apply geo- physical and chemical properties of radon gas in the field of mining engineering, and imported radioac- tive measurement method to detect the development process of the overlying strata mining-induced fractures and their contained water quality in underground coal mining, which not only innovates a more simple-fast-reliable detection method, but also further expands the applications of radon gas detection technology in mining field. A 3D simulation design of comprehensive testing system for detecting strata mining-induced fractures on surface with radon gas (CTSR) was carried out by using a large-scale 3D solid model design software Pro/Engineer (Pro/E), which overcame three main disadvantages of ''static design thought, 2D planar design and heavy workload for remodification design'' on exiting design for mining engineering test systems. Meanwhile, based on the simulation design results of Pro/E software, the sta- bility of the jack-screw pressure bar for the key component in CTSR was checked with a material mechan- ics theory, which provided a reliable basis for materials selection during the latter machining process.
文摘Ⅰ The Indexes of Detecting Oil and Gas Resources The deeply buried reservoir which in a dynamic equilibrium state has a great pressure inside, and between it and earth surface there is a great difference of pressure. Therefore the hydrocarbon must spread and move vertically to the surface along the pressure gradient orientation. Hydrocarbons in the reservoir along some small rifts, cracks, joints and cleavages penetrate the overlying strata and seepage onto the surface. Thus the hydrocarbons become unvisble oil and gas signs. This process is called the phenomena of hydrocarbon microseepage of reservoir. Hydrocarbons microseepage in the process
文摘The implementation of expressway project construction and project management requires a full understanding of the importance of carrying out inspection activities and implementation, and the full implementation of this work. Carry out measurement hoisting, laboratory inspection, quality control during construction and test inspection before acceptance of materials before construction to ensure the implementation of test and inspection work, ensure the quality and benefit of highway engineering projects, and reduce hidden dangers and risks and problems during construction to effectively play its value and role. It is also necessary to recognize the professionalism and complexity of the implementation of relevant tasks, pay attention to strengthening the work in this area, improve the professional skills and comprehensive quality of inspectors, standardize the inspection process, and effectively improve the inspection level and performance.
文摘With the construction of roads, China's economic and social development is faster and faster, and road construction in economic development is also more and more important, therefore, countries will focus on road construction. In the process of highway construction, test and inspection is an important measure to guarantee highway quality and improve the economic benefit of highway construction. From the current situation of our country, the highway test management level is not high. Therefore, based on the highway test management, this paper first states the importance of the highway test management, and then puts forward relevant solutions to improve the management level. In this hope to help the relevant construction units, and then improve their management level, to ensure the quality of highway.
文摘Highway engineering testing is an important part of highway engineering technology management, the results of which determine whether the quality of highway engineering is qualified, whether it can be accepted and successfully implemented after the completion of the project. With the improvement of the scale and level of highway construction in China, the development of highway engineering test and test has not kept pace with the development of highway construction industry, and some problems have gradually become prominent in the work. This paper introduces the importance and necessity of highway engineering test, finds out the common problems and puts forward the solutions.
文摘In recent years,the scale of China’s highway projects have been expanding.However,in real life,road construction projects in some places have not passed professional and rigorous inspections,resulting in various quality problems,and seriously affecting the safety of drivers and pedestrians.This paper analyzes the current situation of highway engineering test and detection,expounds the application of new technologies for highway engineering test and detection.In this paper,a case study was carried out on ground penetrating radar(GPR),which aims to improve highway engineering test and detection and provide reference for reducing highway safety risks.
文摘China in the actual development process of the basic engineering construction invested huge human and material resources, and perfect the basic engineering also laid a solid foundation for the rapid economic development of China, which shows the important role of highway traffic engineering in the practical application process. For this reason, China has been strengthening the quality control of highway traffic engineering, through the establishment of a strict test testing system to control the quality of highway traffic engineering construction. Based on this, this paper will summarize the significance of engineering test and test, focus on the analysis of test and test technology key points and put forward the optimization of engineering test and test measures, hope to provide reference for relevant staff.
文摘California Bearing Ratio(CBR)test is highly professional and requires a high level of skills.In order to improve the accuracy of the test results,the relevant staff will not only need to understand the rules and procedures involved in the test,they would also need to be meticulous in their work to avoid human errors,provide good data support for highway engineering,and improve the overall quality of the project.Therefore,this paper presents an analysis of the application of CBR test in highway engineering,which can provide reference for engineering and promote the development of the highway industry.
基金supported by the National Natural Science Foundation of China(61571434)
文摘This paper deals with the problem of detecting a signal whose amplitude is a scaling factor in the presence of homogeneous Gaussian noise with unknown covariance matrix.Since no uniformly most powerful test exists for the problem at hand,we devise and assess a detection strategy based on the well-known Durbin test design criteria.The closed-form expressions for the probabilities of false alarm and detection of the Durbin test are derived,which show that it bears a constant false alarm rate property against the noise covariance matrix.At the analysis stage,the performance of the new receiver is assessed,also in comparison with some classical adaptive detectors,both in matched and in mismatched signal cases.The results show that the proposed detector achieves a visible performance improvement in the presence of severe steering vector mismatch,while maintaining an acceptable detection loss for matched signal.
文摘To generate test vector sets that can efficiently activate hardware Trojans and improve probability of the hardware Trojan activation,an efficient hardware Trojan activation method is proposed based on greedy algorithm for combinatorial hardware Trojans. Based on the greedy algorithm and the recursive construction method in the combination test,the method formulates appropriate and useful greedy strategy and generates test vector sets with different combinatorial correlation coefficients to activate hardware Trojans in target circuits. The experiment was carried out based on advanced encryption standard（ AES） hardware encryption circuit,different combinatorial hardware Trojans were implanted in AES as target circuits,the experiment of detecting hardware Trojans in target circuits was performed by applying the proposed method and different combinatorial hardware Trojans in target circuits were activated successfully many times in the experiment. The experimental results showthat the test vector sets generated using the proposed method could effectively activate combinatorial hardware Trojans,improve the probability of the hardware Trojan being activated,and also be applied to practice.
基金supported by National Natural Science Foundation of China(62120106004)Key Project of Zhejiang Province(2023C03104,2024C03146)the Fundamental Research Funds for the Central Universities(226-2024-00059).
文摘In cancer cells,higher reactive oxygen species(ROS)than normal cells were observed due to hypermetabolism.The redox balance in cancer cells relies on accordingly upregulated antioxidant capacity.By manipulating oxidation and antioxidant systems,chemotherapeutic drugs can selectively kill cancer cells without hurting normal cells.As threedimensional(3D)in vitro models,such as spheroids and organoids,have become widely used in cancer research,traditional detection methods(e.g.,absorption tests or titration)are inadequate for detecting in 3D environments.Thus,it is crucial to find a new method to detect oxidative stress of 3D in vitro cancer models.Here,a nanocomposite electrochemical biosensor was exploited to evaluate oxidative stress of cancer cells cultured in the 3D environment.The oxidation-regulatory capacity of honokiol,a Magnolia genus-derived anti-cancer molecule,was evaluated.A screen-printed electrode(SPCE)was modified with reduced graphene oxide(RGO)and platinum nanoparticles(Pt NPs)to get Pt NPs/RGO/SPCE.Then the gelatin methacrylate/reduced graphene oxide(GelMA/RGO)hydrogel was applied to immobilized NCI-H1975 in a 3D bionic environment to get NCI-H1975/GelMA/RGO/Pt NPs/RGO/SPCE.After optimizing the experiment condition,the Pt NPs/RGO/SPCE showed a detection threshold of 0.65μM and a linear field from 1 to 10μM for H_(2)O_(2)detection while the NCI-H1975/GelMA/RGO/Pt NPs/RGO/SPCE sensitively responded to H_(2)O_(2)-induced oxidative stress.By utilizing the NCI-H1975/GelMA/RGO/Pt NPs/RGO/SPCE we found honokiol(a natural polyphenol constituent)inhibits NCI-H1975 by inducing oxidative stress.This simple cell-based electrochemical biosensor can in situ evaluate oxidative stress of 3D cancer models conveniently.It can also be easily extended to the study of the mechanism of action of other drugs and holds broad application prospects in the fields of new drug development and drug repurposing.
文摘A superconducting solenoid prototype magnet for Accelerator Driven Snbcritical System（ADS） Injection I has been designed and fabricated,which has also been tested in a liquid Helium state inside a vertical Dewar in the Haerbin institute of Technology in November 2012.The design current was 210 A.when the test current reached400 A no quench occurred so the solenoid magnet was forced to quench by the embedded heaters.The integral field strength,leakage held at the nearby upstream and downstream superconducting spoke cavities all meet the design requirements.At the same time,it also checked the reliability of the vertical test Dewar and the quenched detection system.The superconducting prototype magnet has accumulated valuable experiences for the coming batch magnets production and cryogenic test.
