Temporomandibular joint(TMJ)disc displacement is one of the most significant subtypes of temporomandibular joint disorders,but its etiology and mechanism are poorly understood.In this study,we elucidated the mechanism...Temporomandibular joint(TMJ)disc displacement is one of the most significant subtypes of temporomandibular joint disorders,but its etiology and mechanism are poorly understood.In this study,we elucidated the mechanisms by which destruction of inflamed collagen fibrils induces alterations in the mechanical properties and positioning of the TMJ disc.By constructing a rat model of TMJ arthritis,we observed anteriorly dislocated TMJ discs with aggravated deformity in vivo from five weeks to six months after a local injection of Freund’s complete adjuvant.By mimicking inflammatory conditions with interleukin-1 beta in vitro,we observed enhanced expression of collagen-synthesis markers in primary TMJ disc cells cultured in a conventional two-dimensional environment.In contrast,three-dimensional(3D)-cultivated disc cell sheets demonstrated the disordered assembly of inflamed collagen fibrils,inappropriate arrangement,and decreased Young’s modulus.Mechanistically,inflammation-related activation of the nuclear factor kappa-B(NF-κB)pathway occurs during the progression of TMJ arthritis.NF-κB inhibition reduced the collagen fibril destruction in the inflamed disc cell sheets in vitro,and early NF-κB blockade alleviated collagen degeneration and dislocation of the TMJ discs in vivo.Therefore,the NF-κB pathway participates in the collagen remodeling in inflamed TMJ discs,offering a potential therapeutic target for disc displacement.展开更多
Evaluating the performance of existing concrete structures is essential in civil engineering,with compressive strength serving as an indicator of performance.Non-destructive testing(NDT)techniques are commonly employe...Evaluating the performance of existing concrete structures is essential in civil engineering,with compressive strength serving as an indicator of performance.Non-destructive testing(NDT)techniques are commonly employed due to their cost-effectiveness and the ability to assess structural integrity without causing damage.However,NDT methods often yield less accurate results than destructive testing(DT),which,although highly reliable,is costly and invasive.To address this limitation,recent research has focused on developing predictive models that correlate DT and NDT outcomes using machine learning techniques.This study explores the application of Support Vector Machine(SVM)models,enhanced with optimization techniques,to improve prediction accuracy.Experimental concrete practical samples,ranging from M10 to M40 grade,were prepared and tested at 14 and 28 days of curing,totaling 126 laboratory specimens.Additionally,231 field samples were collected from a 20-year-old structure to reflect in situ conditions.The performance of SVM was improved using optimization algorithms such as Bayesian Optimization and Genetic Algorithms(GA).Among various kernel functions tested,the Gaussian non-linear kernel proved most effective in modeling the complex relationship between NDT and DT results.The SVM model optimized using Bayesian methods and a Gaussian kernel achieved superior performance,with a high coefficient of determination(R²=0.9771)and significantly lower error metrics,including Mean Squared Error(MSE),Root Mean Squared Error(RMSE),and Mean Absolute Error(MAE).Bayesian-optimized SVM with a Gaussian kernel offers a highly accurate and practical tool for predicting compressive strength from NDT data,enhancing decision-making in structural assessment.展开更多
Catalytic destruction is an ascendant technology for the abatement of volatile organic compounds(VOCs)originating fromsolvent-based industrial processes.The varied composition tends to influence each VOC’s catalytic ...Catalytic destruction is an ascendant technology for the abatement of volatile organic compounds(VOCs)originating fromsolvent-based industrial processes.The varied composition tends to influence each VOC’s catalytic behavior in the reaction mixture.We investigated the catalytic destruction of multi-component VOCs including dichloromethane(DCM)and ethyl acetate(EA),as representatives from pharmaceutical waste gases,over co-supported HxPO_(4)-RuOx/CeO_(2) catalyst.A mutual inhibitory effect relating to concentrations because of competitive adsorption was verified in the binary VOCs oxidation and EA posed a more negative effect on DCM oxidation owing to EA’s superior adsorption capacity.Preferential adsorption of EA on acidic sites(HxPO_(4)/CeO_(2))promoted DCM activation on basic sites(O^(2−))and the dominating EA oxidation blocked DCM’s access to oxidation centers(RuOx/CeO_(2)),resulting in boosted monochloromethane yield and increased chlorine deposition for DCM oxidation.The impaired redox ability of Ru species owing to chlorine deposition in turn jeopardized deep oxidation of EA and its by-products,leading to increased gaseous by-products such as acetic acid originating fromEA pyrolysis.Notably,DCM at low concentration slightly promoted EA conversion at low temperatures with or without water,consistent with the enhanced EA adsorption in co-adsorption analyses.This was mainly due to that DCM impeded the shielding effect of hydrolysate deposition from rapid EA hydrolysis depending on the decreased acidity.Moreover,water benefited EA hydrolysis but decreased CO_(2) selectivity while the generated water derived from EA was likely to affect DCM transformation.This work may provide theoretical guidance for the promotion of applied catalysts toward industrial applications.展开更多
To investigate the evolution of load-bearing characteristics of pre-stressed beams throughout their service life and to provide a basis for accurately assessing the actual working state of damaged pre-stressed concret...To investigate the evolution of load-bearing characteristics of pre-stressed beams throughout their service life and to provide a basis for accurately assessing the actual working state of damaged pre-stressed concrete T-beams,destructive tests were conducted on full-scale pre-stressed concrete beams.Based on the measurement and ana-lysis of beam deflection,strain,and crack development under various loading levels during the research tests,combined with the verification coefficient indicators specified in the codes,the verification coefficients of bridges at different stages of damage can be examined.The results indicate that the T-beams experience complete,incom-plete linear,and non-linear stages during the destructive test process.In the complete linear elastic stage,both the deflection and bottom strain verification coefficients comply with the specifications,indicating a good structural load-bearing capacity no longer adheres to the code’s requirements.In the non-linear stage,both coefficients exhi-bit a sharp increase,resulting in a further decrease in the structure’s load-bearing capacity.According to the pro-visions of the current code,the beam can be in the incomplete linear stage when both values fall within the code’s specified range.The strain verification coefficient sourced from the compression zone at the bottom of theflange is not recommended for assessing the bridge’s load-bearing capacity.展开更多
Photocatalytic disinfection is an eco-friendly strategy for countering bacterial pollution in aquatic environments.Numerous strategies have been devised to facilitate the generation of reactive oxygen species(ROS)with...Photocatalytic disinfection is an eco-friendly strategy for countering bacterial pollution in aquatic environments.Numerous strategies have been devised to facilitate the generation of reactive oxygen species(ROS)within photocatalysts,ultimately leading to the eradication of bacteria.However,the significance of the physical morphology of photocatalysts in the context of sterilization is frequently obscured,and the progress in the development of physical-chemical synergistic sterilization photocatalysts has been relatively limited.Herein,graphitic carbon nitride(g-C_(3)N_(4))is chemically protonated to expose more sharp edges.PL fluorescence and EIS results indicate that the protonation can accelerate photogenerated carrier separation and enhance ROS production.Meanwhile,the sharp edges on the protonated g-C_(3)N_(4)facilitate the physical disruption of cell walls for further promoting oxidative damage.Protonated C_(3)N_(4)demonstrated superior bactericidal performance than that of pristine g-C_(3)N_(4),effectively eliminating Escherichia coli within 40 minutes under irradiation.This work highlights the significance of incorporating physical and chemical synergies in photocatalyst design to enhance the disinfection efficiency of photocatalysis.展开更多
With the continuous advancement of communication and unmanned aerial vehicle(UAV)technologies,the collaborative operations of diverse platforms,including UAVs and ground vehicles,have been significantly promoted.Howev...With the continuous advancement of communication and unmanned aerial vehicle(UAV)technologies,the collaborative operations of diverse platforms,including UAVs and ground vehicles,have been significantly promoted.However,battlefield uncertainties,such as equipment failures and enemy attacks,can impact these collaborative operations'stability and communication efficiency.To this end,we design a highly destruction-resistant air-ground cooperative resilient networking platform that aims to enhance the robustness of network communications by integrating ground vehicle information for UAV network deployment.It then incorporates the concept of virtual guiding force,enabling the UAV swarm to adaptively configure its network layout based on ground vehicle information,thereby improving network destruction resistance.Simulation results demonstrate that the UAV swarm involved in the proposed platform exhibits balanced flight energy consumption and excellent performance in network destruction resistance.展开更多
Air blasts induced by rock-ice avalanches are common natural phenomena known for their far-field destructive impact.In this study,remote sensing images,eyewitness videos and numerical modelling were comprehensively ap...Air blasts induced by rock-ice avalanches are common natural phenomena known for their far-field destructive impact.In this study,remote sensing images,eyewitness videos and numerical modelling were comprehensively applied to analyze the initiation and propagation of the 2021 Chamoli avalancheinduced air blast.Our findings indicate that air blasts are observed from the avalanche source area to the Rishiganga valley,but nearly disappear in the Dhauliganga valley.The most intense air blast is concentrated on the left side of Ronti Gad valley,with maximum velocity and pressure estimated at over 70 m/s and 20 kPa,respectively.Such high pressure results in widespread tree breakage in the area.Based on the analysis of the Chamoli event,we further discussed the potential contribution of the avalanche flow regime,avalanche dynamics and geomorphology to the destructive potential of air blasts.Rapidly moved sliding mass can impart the air blast a high initial momentum,and this process will be exaggerated when the avalanche impacts valley walls at bends.However,when the rock-ice avalanche transforms into a debris-enriched flash flood,free water within the flowing mass can displace air,inhibiting the generation of air blasts.Our work offers new insights into the generation and propagation of rock-ice avalanche-induced air blasts,underscoring the importance of including this type of hazard during avalanche risk assessment in high-altitude glacial regions.展开更多
BACKGROUND Although laparoscopic gastrolithotomy had been widely used in clinical practice,uncommon postoperative complications still require vigilance by medical staff.CASE SUMMARY Here we report a 67-year-old man wh...BACKGROUND Although laparoscopic gastrolithotomy had been widely used in clinical practice,uncommon postoperative complications still require vigilance by medical staff.CASE SUMMARY Here we report a 67-year-old man who suffered for 18 months and underwent surgery several times due to a rare and undetected complication of laparoscopic gastricolithotomy.He presented to multiple hospitals because of sustained left upper quadrant abdominal pain one month after laparoscopic gastricolithotomy due to a large gastric bezoar caused by unrestrained eating of black dates and was diagnosed with possible intercostal neuritis.Many painkillers were used to relieve his symptoms but the condition progressed.Seven months after surgery,he was hospitalized as skin ulceration occurred in the left upper abdominal wall and was subsequently diagnosed with a massive thoracoabdominal wall abscess.One year after surgery,irreversible costal destruction was demonstrated.Both lesions were finally proved to be secondary damage due to a rare chronic gastro-abdominal wall fistula related to laparoscopic gastricolithotomy and the diameter of the gastric fistula reached 2 centimeters(cm).The patient was ultimately cured but underwent multi-regional incisions and drainage of the abscess,drainage of the gastric fistula,partial gastrectomy and removal of damaged ribs,and was followed-up for more than 4 years without recurrence.It is well-known that gastric fistula usually has an acute onset and occurs early after surgery,while chronic gastro-abdominal wall fistula especially with secondary massive thoracoabdominal wall abscess and costal destruction has rarely been reported.CONCLUSION This may be the first reported case of a chronic thoracoabdominal abscess and costal destruction caused by an undetected chronic gastro-abdominal wall fistula.We believe that this is a novel type of gastric fistula and the diagnosis and treatment were challenging.展开更多
Dear Editor,I am Yuki Tanaka from Hakodate Central General Hospital,Japan.Mikulicz’s disease is characterized by symmetrical swelling of lacrimal and salivary glands.In 2012,a Japanese study group proposed comprehens...Dear Editor,I am Yuki Tanaka from Hakodate Central General Hospital,Japan.Mikulicz’s disease is characterized by symmetrical swelling of lacrimal and salivary glands.In 2012,a Japanese study group proposed comprehensive diagnostic criteria for immunoglobulin G4-related disease(IgG4-RD)^([1]).They have revealed that Mikulicz’s disease is a systemic IgG4-RD and attracted attentions of ophthalmologists.In 2014,the criteria for IgG4-related ophthalmic disease(IgG4-ROD)were established.展开更多
In order to improve the destruction efficiency of dioxins and also for developing new dioxin control technology, the destruction mechanisms of 2,3,7,8-tetrachlorodihenzo-p-dioxin （2,3,7,8-TCDD） by O3 and NO3, were i...In order to improve the destruction efficiency of dioxins and also for developing new dioxin control technology, the destruction mechanisms of 2,3,7,8-tetrachlorodihenzo-p-dioxin （2,3,7,8-TCDD） by O3 and NO3, were investigated employing quantum chemical calculations. For involved reactions, the microcosmic reaction processes were analyzed and depicted in detail based on geometry optimizations made by the B3LYP/6-31G（d） method. At the same time, the reaction activation energies were also calculated at the MP2/6- 311G（d,p）//B3LYP/6-31G（d） level. Configuration analysis indicated that 2,3,7,8-TCDD could be destroyed by 03 and NO3 in two different ways. The destruction of 2,3,7,8-TCDD by 03 proceeded via the addition of 03 and the cleavage of C=C while the destruction of 2,3,7,8-TCDD by NO3 proceeded via the substitution of chlorine by NO3. Calculated results show that, the activation energy of the destruction reaction of 2,3,7,8-TCDD by NO3 （267.48 kJ/mol） is much larger than that of the destruction reaction of 2,3,7,8-TCDD by O3 （51.20 kJ/mol）. This indicated that the destruction of 2,3,7,8-TCDD by 03 is much more efficient than that of 2,3,7,8-TCDD by NO3. The reason why the activation energy for the destruction reaction of 2,3,7,8-TCDD by NO3 is so large, is also discussed.展开更多
Unidirectional carbon/carbon（C/C） composites modified with in situ grown carbon nanofibers（CNFs） were prepared by catalysis chemical vapor deposition. The effect of in situ grown CNFs on the flexural properties of...Unidirectional carbon/carbon（C/C） composites modified with in situ grown carbon nanofibers（CNFs） were prepared by catalysis chemical vapor deposition. The effect of in situ grown CNFs on the flexural properties of the C/C composites was investigated by detailed analyses of destructive process. The results show that there is a sharp increase in the flexural load-displacement curve in the axial direction of the CNF-C/C composites, followed by a serrated yielding phenomenon similar to the plastic materials. The failure mode of the C/C composites modified with in situ grown CNFs is changed from the pull-out of single fiber to the breaking of fiber bundles. The existence of interfacial layer composed by middle-textured pyrocarbon, CNFs and high-textured pyrocarbon can block the crack propagation and change the propagation direction of the main crack, which leads to the higher flexural strength and modulus of C/C composites.展开更多
We aimed to investigate the synergistic effects of ultrasonic waves and repeated freeze-thaw cycles on cel-wal destruction of Auricularia auric-ula mycelia, and determine the best combination of conditions for cel-wal...We aimed to investigate the synergistic effects of ultrasonic waves and repeated freeze-thaw cycles on cel-wal destruction of Auricularia auric-ula mycelia, and determine the best combination of conditions for cel-wal destruc-tion of Auricularia auricula mycelia. [Method] The effects of destruction time, added water, destruction times, freeze time and number of freeze-thaw cycles during ultra-sonic treatment on polysaccharide yield were investigated by single-factor test in our research. The optimum conditions for cel-wal destruction of Auricularia auricula mycelia by the synergistic effect of ultrasonic waves and repeated freeze-thaw cycles were ascertained by orthogonal test. [Result] The results of single test indicated the best combination of conditions was as fol ows： freeze time, 30 min; destruction time, 20 min; added water, 15 times; destruction times, 2 times; number of freeze-thaw cycles, 3 cycles. The results of orthogonal test indicated the influencing factors ranked as destruction time 〉 destruction times 〉 freeze time. The best combination of conditions was as fol ows： freeze time, 30 min; destruction time, 25 min; destruc-tion times, 2 times. Under above conditions, the polysaccharide yield reached 57.76 mg/g. [Conclusion] This research would provide a basis and reference for practical production.展开更多
Pulsed eddy current （PEC） non-destructive test- ing and evaluation （NDT＆E） has been around for some time and it is still attracting extensive attention from researchers around the globe, which can be witnessed th...Pulsed eddy current （PEC） non-destructive test- ing and evaluation （NDT＆E） has been around for some time and it is still attracting extensive attention from researchers around the globe, which can be witnessed through the reports reviewed in this paper. Thanks to its richness of spectral components, various applications of this technique have been proposed and reported in the lit- erature covering both structural integrity inspection and material characterization in various industrial sectors. To support its development and for better understanding of the phenomena around the transient induced eddy currents, attempts for its modelling both analytically and numeri- cally have been made by researchers around the world. This review is an attempt to capture the state-of-the-art development and applications of PEC, especially in the last 15 years and it is not intended to be exhaustive. Future challenges and opportunities for PEC NDT＆E are also presented.展开更多
This paper analyzes the destructive effect of lawlessness on Dorian Gray in The Picture of Dorian Gray and Kurtz in Heart of Darkness.Under the protection of his portrait,Dorian Gray is lost in his seeking for pleasur...This paper analyzes the destructive effect of lawlessness on Dorian Gray in The Picture of Dorian Gray and Kurtz in Heart of Darkness.Under the protection of his portrait,Dorian Gray is lost in his seeking for pleasure and corrupts from a good angel into a vicious devil.As an oppressor in Africa,Kurtz can make his law and can do anything without punishment and is thus destroyed by his insatiable desire for ivory.The corruption of Dorian Gray and Kurtz shows that without observation,man may expose his evil side to an extreme.展开更多
This essay is going to read the different kinds of beings in The Lord of the Rings as different stages of man,and to analyze how they construct or destruct their selves respectively over power.The Lord of the Rings is...This essay is going to read the different kinds of beings in The Lord of the Rings as different stages of man,and to analyze how they construct or destruct their selves respectively over power.The Lord of the Rings is read as a story about the self-construction and self-destruction of man,who begins to construct the sense of self from a very early stage in life,and becomes who he is in the continuous process of trying to identify himself with the image that keeps changing,of the frequently alternative construction and destruction of his self,and of intersubjectivity,the interrelation with other subjects.展开更多
This paper involves a series of destructive full-scale load tests on long bored piles instrumented with strain gauges along the shafts,including two compression and two tension loading tests.The load-displacement resp...This paper involves a series of destructive full-scale load tests on long bored piles instrumented with strain gauges along the shafts,including two compression and two tension loading tests.The load-displacement response,axial force,skin friction,and the thresholds of the slip displacement for fully mobilizing the skin resistances in different soils are discussed.Moreover,the theoretical solution for estimating the pile tip settlement under compression was adopted to analyze the test results.It was found that the measured skin frictions for the piles under compression were about 6% to 42% higher than the estimated values of the cone penetration tests(CPTs),whereas the measured skin frictions in the uplift cases were about 16% to 50% smaller than the estimated values.In addition,the average limited skin frictions for the tension piles were about 0.36 to 0.78 times the average ultimate skin frictions for the piles under compression.It also can be indicated that the skin friction along the pile depth approached the limited state,and decreased from a peak value with increasing loads.展开更多
PCDD/Fs have been become a serious issue because of their toxicological effects and associated adverse health implications. In this study, the gliding arc plasma was tested for treatment of polychlorinated dibenzo-p-d...PCDD/Fs have been become a serious issue because of their toxicological effects and associated adverse health implications. In this study, the gliding arc plasma was tested for treatment of polychlorinated dibenzo-p-dioxins （PCDDs） and polychlorinated dibenzofurans （PCDFs）, which was synthesized from pentachlorophenol in atmospheric condition at 350℃ with or without the catalysis of CuCl2. From the experiment, we found that the destruction efficiency of PCDD/F homologues after gliding was discharge ranged from 25% to 79%. This result demonstrates that gliding arc plasma is an effective technology to decompose PCDDs/Fs in flue gas. A plausible degradation mechanism for PCDD/Fs by gliding arc was discussed. Finally, a multistage reactor structure of gliding arc was proposed to upgrade removal efficiency for PCDD/Fs.展开更多
[Objective]To investigate the inhibitory effect ofhonokiol on Candida albicans in vitro.[Methods]The minimum inhibitory concentration(MIC)and minimum fungicidal concentration(MFC)of magnolol for C.albicans were determ...[Objective]To investigate the inhibitory effect ofhonokiol on Candida albicans in vitro.[Methods]The minimum inhibitory concentration(MIC)and minimum fungicidal concentration(MFC)of magnolol for C.albicans were determined by microdilution method.Transmission electron microscopy was used to examine the effect of different concentrations of honokiol on the ultrastructure of C.albicans.Apoptosis of C.albicans caused by honokiol was analyzed by Annexin V-FITC/propidium iodide(PI)double staining and the accumulation of reactive oxygen species(ROS)in C.albicans cells was determined by DCFH-DA staining.The effects of honokiol on mitochondrial membrane potential and cell membrane permeability of C.albicans were analyzed by JC-1 staining and PI staining respectively.[Results]Honokiol had strong inhibitory effect on C.albicans,with MIC90 of 16μg/mL and MFC of 32μg/mL.Honokiol affected cell wall,cell membrane,and cytoplasm of C.albicans,induced both apoptosis and necrosis in C.albicans,probably through ROS production and disruption of mitochondrial function.It also changed the permeability of cell membrane,leaded to the cell wall damage and the binding of ergosterol.[Conclusion]Inhibition of C.albicans by honikiol involves multiple mechanisms including ROS production accompanied by a series of cellular damages.Honikiol appears to be a potential antifungal drug candidate.展开更多
基金supported by the National Natural Science Foundation of China Nos.82370983,81671015(X.W.),82230030(Y.L.),82101043(S.C.)and 82370922(Y.F.)Beijing International Science and Technology Cooperation Project No.Z221100002722003(Y.L.)+4 种基金Beijing Natural Science Foundation Nos.L234017,JL23002(Y.L.),No.7242282(S.C.)and 7232217(Y.G.)Clinical Medicine Plus X-Young Scholars Project of Peking University No.PKU2024LCXQ039(Y.L.)National Program for Multidisciplinary Cooperative Treatment on Major Diseases No.PKUSSNMP-202013(X.W.)Hygiene and Health Development Scientific Research Fostering Plan of Haidian District Beijing No.HP2023-12-509001(J.Z.)Young Clinical Research Fund of the Chinese Stomatological Association No.CSA-02022-03(J.Z.).
文摘Temporomandibular joint(TMJ)disc displacement is one of the most significant subtypes of temporomandibular joint disorders,but its etiology and mechanism are poorly understood.In this study,we elucidated the mechanisms by which destruction of inflamed collagen fibrils induces alterations in the mechanical properties and positioning of the TMJ disc.By constructing a rat model of TMJ arthritis,we observed anteriorly dislocated TMJ discs with aggravated deformity in vivo from five weeks to six months after a local injection of Freund’s complete adjuvant.By mimicking inflammatory conditions with interleukin-1 beta in vitro,we observed enhanced expression of collagen-synthesis markers in primary TMJ disc cells cultured in a conventional two-dimensional environment.In contrast,three-dimensional(3D)-cultivated disc cell sheets demonstrated the disordered assembly of inflamed collagen fibrils,inappropriate arrangement,and decreased Young’s modulus.Mechanistically,inflammation-related activation of the nuclear factor kappa-B(NF-κB)pathway occurs during the progression of TMJ arthritis.NF-κB inhibition reduced the collagen fibril destruction in the inflamed disc cell sheets in vitro,and early NF-κB blockade alleviated collagen degeneration and dislocation of the TMJ discs in vivo.Therefore,the NF-κB pathway participates in the collagen remodeling in inflamed TMJ discs,offering a potential therapeutic target for disc displacement.
文摘Evaluating the performance of existing concrete structures is essential in civil engineering,with compressive strength serving as an indicator of performance.Non-destructive testing(NDT)techniques are commonly employed due to their cost-effectiveness and the ability to assess structural integrity without causing damage.However,NDT methods often yield less accurate results than destructive testing(DT),which,although highly reliable,is costly and invasive.To address this limitation,recent research has focused on developing predictive models that correlate DT and NDT outcomes using machine learning techniques.This study explores the application of Support Vector Machine(SVM)models,enhanced with optimization techniques,to improve prediction accuracy.Experimental concrete practical samples,ranging from M10 to M40 grade,were prepared and tested at 14 and 28 days of curing,totaling 126 laboratory specimens.Additionally,231 field samples were collected from a 20-year-old structure to reflect in situ conditions.The performance of SVM was improved using optimization algorithms such as Bayesian Optimization and Genetic Algorithms(GA).Among various kernel functions tested,the Gaussian non-linear kernel proved most effective in modeling the complex relationship between NDT and DT results.The SVM model optimized using Bayesian methods and a Gaussian kernel achieved superior performance,with a high coefficient of determination(R²=0.9771)and significantly lower error metrics,including Mean Squared Error(MSE),Root Mean Squared Error(RMSE),and Mean Absolute Error(MAE).Bayesian-optimized SVM with a Gaussian kernel offers a highly accurate and practical tool for predicting compressive strength from NDT data,enhancing decision-making in structural assessment.
基金supported by the National Natural Science Foundation of China (Nos.21906087 and 52070168)the Key R&D Plan of Zhejiang Province (No.2023C03127)the Fundamental Research Funds for the Central Universities (No.226-2022-00150).
文摘Catalytic destruction is an ascendant technology for the abatement of volatile organic compounds(VOCs)originating fromsolvent-based industrial processes.The varied composition tends to influence each VOC’s catalytic behavior in the reaction mixture.We investigated the catalytic destruction of multi-component VOCs including dichloromethane(DCM)and ethyl acetate(EA),as representatives from pharmaceutical waste gases,over co-supported HxPO_(4)-RuOx/CeO_(2) catalyst.A mutual inhibitory effect relating to concentrations because of competitive adsorption was verified in the binary VOCs oxidation and EA posed a more negative effect on DCM oxidation owing to EA’s superior adsorption capacity.Preferential adsorption of EA on acidic sites(HxPO_(4)/CeO_(2))promoted DCM activation on basic sites(O^(2−))and the dominating EA oxidation blocked DCM’s access to oxidation centers(RuOx/CeO_(2)),resulting in boosted monochloromethane yield and increased chlorine deposition for DCM oxidation.The impaired redox ability of Ru species owing to chlorine deposition in turn jeopardized deep oxidation of EA and its by-products,leading to increased gaseous by-products such as acetic acid originating fromEA pyrolysis.Notably,DCM at low concentration slightly promoted EA conversion at low temperatures with or without water,consistent with the enhanced EA adsorption in co-adsorption analyses.This was mainly due to that DCM impeded the shielding effect of hydrolysate deposition from rapid EA hydrolysis depending on the decreased acidity.Moreover,water benefited EA hydrolysis but decreased CO_(2) selectivity while the generated water derived from EA was likely to affect DCM transformation.This work may provide theoretical guidance for the promotion of applied catalysts toward industrial applications.
文摘To investigate the evolution of load-bearing characteristics of pre-stressed beams throughout their service life and to provide a basis for accurately assessing the actual working state of damaged pre-stressed concrete T-beams,destructive tests were conducted on full-scale pre-stressed concrete beams.Based on the measurement and ana-lysis of beam deflection,strain,and crack development under various loading levels during the research tests,combined with the verification coefficient indicators specified in the codes,the verification coefficients of bridges at different stages of damage can be examined.The results indicate that the T-beams experience complete,incom-plete linear,and non-linear stages during the destructive test process.In the complete linear elastic stage,both the deflection and bottom strain verification coefficients comply with the specifications,indicating a good structural load-bearing capacity no longer adheres to the code’s requirements.In the non-linear stage,both coefficients exhi-bit a sharp increase,resulting in a further decrease in the structure’s load-bearing capacity.According to the pro-visions of the current code,the beam can be in the incomplete linear stage when both values fall within the code’s specified range.The strain verification coefficient sourced from the compression zone at the bottom of theflange is not recommended for assessing the bridge’s load-bearing capacity.
基金supported by the National Natural Science Foundation of China(No.2021YFC3200603)the Special Research Assistant Program,Chinese Academy of Sciences.
文摘Photocatalytic disinfection is an eco-friendly strategy for countering bacterial pollution in aquatic environments.Numerous strategies have been devised to facilitate the generation of reactive oxygen species(ROS)within photocatalysts,ultimately leading to the eradication of bacteria.However,the significance of the physical morphology of photocatalysts in the context of sterilization is frequently obscured,and the progress in the development of physical-chemical synergistic sterilization photocatalysts has been relatively limited.Herein,graphitic carbon nitride(g-C_(3)N_(4))is chemically protonated to expose more sharp edges.PL fluorescence and EIS results indicate that the protonation can accelerate photogenerated carrier separation and enhance ROS production.Meanwhile,the sharp edges on the protonated g-C_(3)N_(4)facilitate the physical disruption of cell walls for further promoting oxidative damage.Protonated C_(3)N_(4)demonstrated superior bactericidal performance than that of pristine g-C_(3)N_(4),effectively eliminating Escherichia coli within 40 minutes under irradiation.This work highlights the significance of incorporating physical and chemical synergies in photocatalyst design to enhance the disinfection efficiency of photocatalysis.
基金supported by the Researchers Supporting Project of King Saud University,Riyadh,Saudi Arabia,under Project RSPD2025R681。
文摘With the continuous advancement of communication and unmanned aerial vehicle(UAV)technologies,the collaborative operations of diverse platforms,including UAVs and ground vehicles,have been significantly promoted.However,battlefield uncertainties,such as equipment failures and enemy attacks,can impact these collaborative operations'stability and communication efficiency.To this end,we design a highly destruction-resistant air-ground cooperative resilient networking platform that aims to enhance the robustness of network communications by integrating ground vehicle information for UAV network deployment.It then incorporates the concept of virtual guiding force,enabling the UAV swarm to adaptively configure its network layout based on ground vehicle information,thereby improving network destruction resistance.Simulation results demonstrate that the UAV swarm involved in the proposed platform exhibits balanced flight energy consumption and excellent performance in network destruction resistance.
基金supported by the National Natural Science Foundation of China(Grant Nos.U2244227,42277126 and 41977215).
文摘Air blasts induced by rock-ice avalanches are common natural phenomena known for their far-field destructive impact.In this study,remote sensing images,eyewitness videos and numerical modelling were comprehensively applied to analyze the initiation and propagation of the 2021 Chamoli avalancheinduced air blast.Our findings indicate that air blasts are observed from the avalanche source area to the Rishiganga valley,but nearly disappear in the Dhauliganga valley.The most intense air blast is concentrated on the left side of Ronti Gad valley,with maximum velocity and pressure estimated at over 70 m/s and 20 kPa,respectively.Such high pressure results in widespread tree breakage in the area.Based on the analysis of the Chamoli event,we further discussed the potential contribution of the avalanche flow regime,avalanche dynamics and geomorphology to the destructive potential of air blasts.Rapidly moved sliding mass can impart the air blast a high initial momentum,and this process will be exaggerated when the avalanche impacts valley walls at bends.However,when the rock-ice avalanche transforms into a debris-enriched flash flood,free water within the flowing mass can displace air,inhibiting the generation of air blasts.Our work offers new insights into the generation and propagation of rock-ice avalanche-induced air blasts,underscoring the importance of including this type of hazard during avalanche risk assessment in high-altitude glacial regions.
文摘BACKGROUND Although laparoscopic gastrolithotomy had been widely used in clinical practice,uncommon postoperative complications still require vigilance by medical staff.CASE SUMMARY Here we report a 67-year-old man who suffered for 18 months and underwent surgery several times due to a rare and undetected complication of laparoscopic gastricolithotomy.He presented to multiple hospitals because of sustained left upper quadrant abdominal pain one month after laparoscopic gastricolithotomy due to a large gastric bezoar caused by unrestrained eating of black dates and was diagnosed with possible intercostal neuritis.Many painkillers were used to relieve his symptoms but the condition progressed.Seven months after surgery,he was hospitalized as skin ulceration occurred in the left upper abdominal wall and was subsequently diagnosed with a massive thoracoabdominal wall abscess.One year after surgery,irreversible costal destruction was demonstrated.Both lesions were finally proved to be secondary damage due to a rare chronic gastro-abdominal wall fistula related to laparoscopic gastricolithotomy and the diameter of the gastric fistula reached 2 centimeters(cm).The patient was ultimately cured but underwent multi-regional incisions and drainage of the abscess,drainage of the gastric fistula,partial gastrectomy and removal of damaged ribs,and was followed-up for more than 4 years without recurrence.It is well-known that gastric fistula usually has an acute onset and occurs early after surgery,while chronic gastro-abdominal wall fistula especially with secondary massive thoracoabdominal wall abscess and costal destruction has rarely been reported.CONCLUSION This may be the first reported case of a chronic thoracoabdominal abscess and costal destruction caused by an undetected chronic gastro-abdominal wall fistula.We believe that this is a novel type of gastric fistula and the diagnosis and treatment were challenging.
文摘Dear Editor,I am Yuki Tanaka from Hakodate Central General Hospital,Japan.Mikulicz’s disease is characterized by symmetrical swelling of lacrimal and salivary glands.In 2012,a Japanese study group proposed comprehensive diagnostic criteria for immunoglobulin G4-related disease(IgG4-RD)^([1]).They have revealed that Mikulicz’s disease is a systemic IgG4-RD and attracted attentions of ophthalmologists.In 2014,the criteria for IgG4-related ophthalmic disease(IgG4-ROD)were established.
文摘In order to improve the destruction efficiency of dioxins and also for developing new dioxin control technology, the destruction mechanisms of 2,3,7,8-tetrachlorodihenzo-p-dioxin （2,3,7,8-TCDD） by O3 and NO3, were investigated employing quantum chemical calculations. For involved reactions, the microcosmic reaction processes were analyzed and depicted in detail based on geometry optimizations made by the B3LYP/6-31G（d） method. At the same time, the reaction activation energies were also calculated at the MP2/6- 311G（d,p）//B3LYP/6-31G（d） level. Configuration analysis indicated that 2,3,7,8-TCDD could be destroyed by 03 and NO3 in two different ways. The destruction of 2,3,7,8-TCDD by 03 proceeded via the addition of 03 and the cleavage of C=C while the destruction of 2,3,7,8-TCDD by NO3 proceeded via the substitution of chlorine by NO3. Calculated results show that, the activation energy of the destruction reaction of 2,3,7,8-TCDD by NO3 （267.48 kJ/mol） is much larger than that of the destruction reaction of 2,3,7,8-TCDD by O3 （51.20 kJ/mol）. This indicated that the destruction of 2,3,7,8-TCDD by 03 is much more efficient than that of 2,3,7,8-TCDD by NO3. The reason why the activation energy for the destruction reaction of 2,3,7,8-TCDD by NO3 is so large, is also discussed.
基金Project(2011CB605804)supported by the National Basic Research Program of ChinaProject(51165006)supported by the National Natural Science Foundation of China+1 种基金Project(BY2013015-32)supported by Cooperative Innovation Fund-Prospective Project of Jiangsu Province,ChinaProject(JUSRP1045)supported by the Fundamental Research Funds for the Central Universities,China
文摘Unidirectional carbon/carbon（C/C） composites modified with in situ grown carbon nanofibers（CNFs） were prepared by catalysis chemical vapor deposition. The effect of in situ grown CNFs on the flexural properties of the C/C composites was investigated by detailed analyses of destructive process. The results show that there is a sharp increase in the flexural load-displacement curve in the axial direction of the CNF-C/C composites, followed by a serrated yielding phenomenon similar to the plastic materials. The failure mode of the C/C composites modified with in situ grown CNFs is changed from the pull-out of single fiber to the breaking of fiber bundles. The existence of interfacial layer composed by middle-textured pyrocarbon, CNFs and high-textured pyrocarbon can block the crack propagation and change the propagation direction of the main crack, which leads to the higher flexural strength and modulus of C/C composites.
文摘We aimed to investigate the synergistic effects of ultrasonic waves and repeated freeze-thaw cycles on cel-wal destruction of Auricularia auric-ula mycelia, and determine the best combination of conditions for cel-wal destruc-tion of Auricularia auricula mycelia. [Method] The effects of destruction time, added water, destruction times, freeze time and number of freeze-thaw cycles during ultra-sonic treatment on polysaccharide yield were investigated by single-factor test in our research. The optimum conditions for cel-wal destruction of Auricularia auricula mycelia by the synergistic effect of ultrasonic waves and repeated freeze-thaw cycles were ascertained by orthogonal test. [Result] The results of single test indicated the best combination of conditions was as fol ows： freeze time, 30 min; destruction time, 20 min; added water, 15 times; destruction times, 2 times; number of freeze-thaw cycles, 3 cycles. The results of orthogonal test indicated the influencing factors ranked as destruction time 〉 destruction times 〉 freeze time. The best combination of conditions was as fol ows： freeze time, 30 min; destruction time, 25 min; destruc-tion times, 2 times. Under above conditions, the polysaccharide yield reached 57.76 mg/g. [Conclusion] This research would provide a basis and reference for practical production.
基金Ministry of Higher Education of Malaysia for funding the project on PEC NDT at IIUM through the research grant FRGS16-059-0558supported by the National Natural Science Foundation of China under research grants 51677187 and 51307172
文摘Pulsed eddy current （PEC） non-destructive test- ing and evaluation （NDT＆E） has been around for some time and it is still attracting extensive attention from researchers around the globe, which can be witnessed through the reports reviewed in this paper. Thanks to its richness of spectral components, various applications of this technique have been proposed and reported in the lit- erature covering both structural integrity inspection and material characterization in various industrial sectors. To support its development and for better understanding of the phenomena around the transient induced eddy currents, attempts for its modelling both analytically and numeri- cally have been made by researchers around the world. This review is an attempt to capture the state-of-the-art development and applications of PEC, especially in the last 15 years and it is not intended to be exhaustive. Future challenges and opportunities for PEC NDT＆E are also presented.
文摘This paper analyzes the destructive effect of lawlessness on Dorian Gray in The Picture of Dorian Gray and Kurtz in Heart of Darkness.Under the protection of his portrait,Dorian Gray is lost in his seeking for pleasure and corrupts from a good angel into a vicious devil.As an oppressor in Africa,Kurtz can make his law and can do anything without punishment and is thus destroyed by his insatiable desire for ivory.The corruption of Dorian Gray and Kurtz shows that without observation,man may expose his evil side to an extreme.
文摘This essay is going to read the different kinds of beings in The Lord of the Rings as different stages of man,and to analyze how they construct or destruct their selves respectively over power.The Lord of the Rings is read as a story about the self-construction and self-destruction of man,who begins to construct the sense of self from a very early stage in life,and becomes who he is in the continuous process of trying to identify himself with the image that keeps changing,of the frequently alternative construction and destruction of his self,and of intersubjectivity,the interrelation with other subjects.
基金Project(No.51078330)supported by the National Natural Science Foundation of China
文摘This paper involves a series of destructive full-scale load tests on long bored piles instrumented with strain gauges along the shafts,including two compression and two tension loading tests.The load-displacement response,axial force,skin friction,and the thresholds of the slip displacement for fully mobilizing the skin resistances in different soils are discussed.Moreover,the theoretical solution for estimating the pile tip settlement under compression was adopted to analyze the test results.It was found that the measured skin frictions for the piles under compression were about 6% to 42% higher than the estimated values of the cone penetration tests(CPTs),whereas the measured skin frictions in the uplift cases were about 16% to 50% smaller than the estimated values.In addition,the average limited skin frictions for the tension piles were about 0.36 to 0.78 times the average ultimate skin frictions for the piles under compression.It also can be indicated that the skin friction along the pile depth approached the limited state,and decreased from a peak value with increasing loads.
基金Project supported by the National Natural Science Foundation of China(No.50476058)Natural Science Foundation of Zhejiang Province(No.X506214)
文摘PCDD/Fs have been become a serious issue because of their toxicological effects and associated adverse health implications. In this study, the gliding arc plasma was tested for treatment of polychlorinated dibenzo-p-dioxins （PCDDs） and polychlorinated dibenzofurans （PCDFs）, which was synthesized from pentachlorophenol in atmospheric condition at 350℃ with or without the catalysis of CuCl2. From the experiment, we found that the destruction efficiency of PCDD/F homologues after gliding was discharge ranged from 25% to 79%. This result demonstrates that gliding arc plasma is an effective technology to decompose PCDDs/Fs in flue gas. A plausible degradation mechanism for PCDD/Fs by gliding arc was discussed. Finally, a multistage reactor structure of gliding arc was proposed to upgrade removal efficiency for PCDD/Fs.
文摘[Objective]To investigate the inhibitory effect ofhonokiol on Candida albicans in vitro.[Methods]The minimum inhibitory concentration(MIC)and minimum fungicidal concentration(MFC)of magnolol for C.albicans were determined by microdilution method.Transmission electron microscopy was used to examine the effect of different concentrations of honokiol on the ultrastructure of C.albicans.Apoptosis of C.albicans caused by honokiol was analyzed by Annexin V-FITC/propidium iodide(PI)double staining and the accumulation of reactive oxygen species(ROS)in C.albicans cells was determined by DCFH-DA staining.The effects of honokiol on mitochondrial membrane potential and cell membrane permeability of C.albicans were analyzed by JC-1 staining and PI staining respectively.[Results]Honokiol had strong inhibitory effect on C.albicans,with MIC90 of 16μg/mL and MFC of 32μg/mL.Honokiol affected cell wall,cell membrane,and cytoplasm of C.albicans,induced both apoptosis and necrosis in C.albicans,probably through ROS production and disruption of mitochondrial function.It also changed the permeability of cell membrane,leaded to the cell wall damage and the binding of ergosterol.[Conclusion]Inhibition of C.albicans by honikiol involves multiple mechanisms including ROS production accompanied by a series of cellular damages.Honikiol appears to be a potential antifungal drug candidate.
