Pyriminostrobin, a new acaricide, was discovered in our previous studies. Because introducing fluorine into organic compounds can increase bioactivity, pyriminostrobin was modified as a series of strobilurin-pyrimidin...Pyriminostrobin, a new acaricide, was discovered in our previous studies. Because introducing fluorine into organic compounds can increase bioactivity, pyriminostrobin was modified as a series of strobilurin-pyrimidine derivatives for biological screening. The compounds were characterized by 1H NMR, MS and elemental analysis. Preliminary bioassays demonstrated that compounds 7e and 7i exhibited significant control against Tetranychus cinnabarinus （Boisd.） at 0.625 mg L^-1, and their acaricidal potencies were higher than pyriminostrobin in a greenhouse. The relationship between structure and acaricidal activity was also studied.展开更多
Employing the intermediate derivatization method（IDM）, twenty novel 1,3,4-oxadiazole derivatives containing arylpyrazoloxyl moiety were designed and synthesized. The structures of the title compounds were identified...Employing the intermediate derivatization method（IDM）, twenty novel 1,3,4-oxadiazole derivatives containing arylpyrazoloxyl moiety were designed and synthesized. The structures of the title compounds were identified by1 H NMR,13 C NMR, MS and elemental analyses, compound 4 was further identified by single-crystal X-ray diffraction. Antifungal activities against rice sheath blight（RSB） and sorghum anthracnose（SA） were evaluated by the mycelium linear growth rate method. Compounds 4, 16 and 20 displayed significant activities against RSB（EC50= 0.88 mg/L, 0.91 mg/L and 0.85 mg/L, respectively）,higher than the reference tebuconazole; While compound 3 exhibited higher activity against SA（EC50= 1.03 mg/L）, equal to commercial pyraclostrobin（EC50= 1.06 mg/L）. The study showed that compound 20 is a promising fungicide for further development.展开更多
Objective To evaluate the difference between Baishao(Paeoniae Radix Alba,PRA)and Chishao(Paeoniae Radix Rubra,PRR)from different regions based on the characteristic spectra of amino acids(AAs).Methods Fingerprints of ...Objective To evaluate the difference between Baishao(Paeoniae Radix Alba,PRA)and Chishao(Paeoniae Radix Rubra,PRR)from different regions based on the characteristic spectra of amino acids(AAs).Methods Fingerprints of the 21 standard AAs were established using O-phthalaldehyde-9-fluorenylmethyl chloroformate(OPA-FMOC)pre-column derivation method.The AA components in PRA and PRR were characterized qualitatively and quantitatively,and different AAs were screened using pattern recognition technology.Results Twelve AAs were identified in both PRA and PRR.Meanwhile,aspartic acid,glutamic acid,arginine,alanine,and gamma-aminobutyric acid were screened as characteristic components,and their concentrations could effectively distinguish PRA from PRR.Conclusion The established characterization method,which is based on the characteristic spectra of AAs,is accurate,efficient,and sensitive and can effectively distinguish between PRA and PRR from different producing areas,thus providing a reference for the overall characterization and evaluation of Chinese medicinal materials.展开更多
Ten coumarin derivatives containing（E）-methyl 2-（methoxyimino）-2-phenylacetate were synthesized and bioassayed.The compounds were identified by IR,~1H NMR and elemental analyses.The test results indicated that com...Ten coumarin derivatives containing（E）-methyl 2-（methoxyimino）-2-phenylacetate were synthesized and bioassayed.The compounds were identified by IR,~1H NMR and elemental analyses.The test results indicated that compound 5j（R^1 is methyl and R^2 is n-C_6H_（13）） was the optimal structure in this paper with good fungicidal activity against CDM（85%） at 6.25 mg/L concentration.展开更多
基金the Outstanding Young Scholarship from the National Natural Science Foundation of China(No.30825043)NSFC(No.21172202)+2 种基金the Outstanding Scholar Foundation of Henan Province(No.094100510019)for financial supportsupported by the National Key Basic Research Program of China(973 Program)(Nos.2010CB126105 and 2012CB724501)the National Key Technology Support Program during the 12th Five-Year Plan Period(Nos.2011BAE06B00,2011BAE06B01,2011BAE06B02,2011BAE06B03 and 2011BAE06B05)
文摘Pyriminostrobin, a new acaricide, was discovered in our previous studies. Because introducing fluorine into organic compounds can increase bioactivity, pyriminostrobin was modified as a series of strobilurin-pyrimidine derivatives for biological screening. The compounds were characterized by 1H NMR, MS and elemental analysis. Preliminary bioassays demonstrated that compounds 7e and 7i exhibited significant control against Tetranychus cinnabarinus （Boisd.） at 0.625 mg L^-1, and their acaricidal potencies were higher than pyriminostrobin in a greenhouse. The relationship between structure and acaricidal activity was also studied.
基金financially supported partially by the Open Foundation of Key Laboratory for Anisotropy and Texture of Materials, Ministry of Education, Northeastern University, China (No. ATM20170001)
文摘Employing the intermediate derivatization method（IDM）, twenty novel 1,3,4-oxadiazole derivatives containing arylpyrazoloxyl moiety were designed and synthesized. The structures of the title compounds were identified by1 H NMR,13 C NMR, MS and elemental analyses, compound 4 was further identified by single-crystal X-ray diffraction. Antifungal activities against rice sheath blight（RSB） and sorghum anthracnose（SA） were evaluated by the mycelium linear growth rate method. Compounds 4, 16 and 20 displayed significant activities against RSB（EC50= 0.88 mg/L, 0.91 mg/L and 0.85 mg/L, respectively）,higher than the reference tebuconazole; While compound 3 exhibited higher activity against SA（EC50= 1.03 mg/L）, equal to commercial pyraclostrobin（EC50= 1.06 mg/L）. The study showed that compound 20 is a promising fungicide for further development.
基金We thank for the funding support from the Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases(No.2018B030322012).
文摘Objective To evaluate the difference between Baishao(Paeoniae Radix Alba,PRA)and Chishao(Paeoniae Radix Rubra,PRR)from different regions based on the characteristic spectra of amino acids(AAs).Methods Fingerprints of the 21 standard AAs were established using O-phthalaldehyde-9-fluorenylmethyl chloroformate(OPA-FMOC)pre-column derivation method.The AA components in PRA and PRR were characterized qualitatively and quantitatively,and different AAs were screened using pattern recognition technology.Results Twelve AAs were identified in both PRA and PRR.Meanwhile,aspartic acid,glutamic acid,arginine,alanine,and gamma-aminobutyric acid were screened as characteristic components,and their concentrations could effectively distinguish PRA from PRR.Conclusion The established characterization method,which is based on the characteristic spectra of AAs,is accurate,efficient,and sensitive and can effectively distinguish between PRA and PRR from different producing areas,thus providing a reference for the overall characterization and evaluation of Chinese medicinal materials.
基金supported by the National Basic Research Program of China(973 Program)(Nos.2003CB114400 and 2010CB126105)
文摘Ten coumarin derivatives containing（E）-methyl 2-（methoxyimino）-2-phenylacetate were synthesized and bioassayed.The compounds were identified by IR,~1H NMR and elemental analyses.The test results indicated that compound 5j（R^1 is methyl and R^2 is n-C_6H_（13）） was the optimal structure in this paper with good fungicidal activity against CDM（85%） at 6.25 mg/L concentration.
