Background:This study aims to investigate the underlying mechanisms between parental marital conflict and adolescent short video dependence by constructing a chain mediation model,focusing on the mediating roles of ex...Background:This study aims to investigate the underlying mechanisms between parental marital conflict and adolescent short video dependence by constructing a chain mediation model,focusing on the mediating roles of experiential avoidance and emotional disturbance(anxiety,depression,and stress).Methods:Conducted in January 2025,the research recruited 4125 adolescents from multiple Chinese provinces through convenience sampling;after data cleaning,3957 valid participants(1959 males,1998 females)were included.Using a cross-sectional design,measures included parental marital conflict,experiential avoidance,anxiety,depression,stress,and short video dependence.Results:Pearson correlation analysis revealed significant positive correlations among all variables.Mediation analysis using the SPSS PROCESS macro showed that parental marital conflict directly predicted short video dependence(β=0.269,p<0.001),and also significantly predicted experiential avoidance(β=0.519,p<0.001),anxiety(β=0.072,p<0.001),depression(β=0.067,p<0.001),and stress(β=0.048,p<0.05).Experiential avoidance further predicted anxiety(β=0.521,p<0.001),depression(β=0.489,p<0.001),stress(β=0.408,p<0.001),and short video dependence(β=0.244,p<0.001).While both anxiety(β=0.050,p<0.05)and depression(β=0.116,p<0.001)positively predicted short video dependence,stress did not(β=0.019,p=0.257).Overall,experiential avoidance,anxiety,depression,and stress significantly mediated the relationship between parental marital conflict and short video dependence.Conclusion:These findings confirm that parental marital conflict not only directly influences adolescent short video dependence but also operates through a chain mediation pathway involving experiential avoidance and emotional disturbance,highlighting central psychological mechanisms and providing theoretical support for integrated mental health and behavioral interventions.展开更多
Dear Editor,The Cay2.1 channel,also known as the P/Q-type Ca^(2+) channel,is a particular type of voltage-gated Ca^(2+) channel primarily expressed on the presynaptic membrane in the brain[1].It serves as an essential...Dear Editor,The Cay2.1 channel,also known as the P/Q-type Ca^(2+) channel,is a particular type of voltage-gated Ca^(2+) channel primarily expressed on the presynaptic membrane in the brain[1].It serves as an essential part of the precisely orchestrated neurotransmitter release machinery.展开更多
Supported metal catalysts are the backbone of heterogeneous catalysis,playing a crucial role in the modern chemical industry.Metal-support interactions(MSIs)are known important in determining the catalytic performance...Supported metal catalysts are the backbone of heterogeneous catalysis,playing a crucial role in the modern chemical industry.Metal-support interactions(MSIs)are known important in determining the catalytic performance of supported metal catalysts.This is particularly true for single-atom catalysts(SACs)and pseudo-single-atom catalysts(pseudo-SACs),where all metal atoms are dispersed on,and interact directly with the support.Consequently,the MSI of SACs and pseudo-SACs are theoretically more sensitive to modulation compared to that of traditional nanoparticle catalysts.In this work,we experimentally demonstrated this hypothesis by an observed size-dependent MSI modulation.We fabricated CoFe_(2)O_(4) supported Pt pseudo-SACs and nanoparticle catalysts,followed by a straightforward water treatment process.It was found that the covalent strong metal-support interaction(CMSI)in pseudo-SACs can be weakened,leading to a significant activity improvement in methane combustion reaction.This finding aligns with our recent observation of CoFe_(2)O_(4) supported Pt SACs.By contrast,the MSI in Pt nanoparticle catalyst was barely affected by the water treatment,giving rise to almost unchanged catalytic performance.This work highlights the critical role of metal size in determining the MSI modulation,offering a novel strategy for tuning the catalytic performance of SACs and pseudo-SACs by fine-tuning their MSIs.展开更多
In this paper,by utilizing the Marcinkiewicz-Zygmund inequality and Rosenthal-type inequality of negatively superadditive dependent(NSD)random arrays and truncated method,we investigate the complete f-moment convergen...In this paper,by utilizing the Marcinkiewicz-Zygmund inequality and Rosenthal-type inequality of negatively superadditive dependent(NSD)random arrays and truncated method,we investigate the complete f-moment convergence of NSD random variables.We establish and improve a general result on the complete f-moment convergence for Sung’s type randomly weighted sums of NSD random variables under some general assumptions.As an application,we show the complete consistency for the randomly weighted estimator in a nonparametric regression model based on NSD errors.展开更多
Rural communities in developing countries often struggle with resource dependency,economic challenges,and poor infrastructure,and villages in Uttarakhand,India,are no exception.This study aims to examine the socioecon...Rural communities in developing countries often struggle with resource dependency,economic challenges,and poor infrastructure,and villages in Uttarakhand,India,are no exception.This study aims to examine the socioeconomic factors influencing forest conservation,assess livelihood dependency on forest resources,and evaluate how socioeconomic status shapes sustainable forest management in Shishambara and Buddhi villages in Dehradun.The study employed purposive and random sampling covering 10%of households,using structured surveys,interviews,field observations,market surveys,and focus group discussions.The survey reveals an agriculture-dominated livelihood,engaging 60%in Buddhi and 65%in Shishambara,alongside private-sector jobs and daily wage labour.Literacy rates differ significantly,with Buddhi at 72%and Shishambara at 58%.Despite accessibility to LPG connections,traditional cooking fuels like fuelwood and cow dung remain predominant,utilized by 70%of households in Buddhi and 75%in Shishambara.Most homes are Pakka,yet only 18.8%in Buddhi and 22%in Shishambara have toilets.Public transport is scarce,leaving villagers reliant on private vehicles.These findings underscore the need for policies that address resource management,improve basic services,and support sustainable development,offering a road map for uplifting rural livelihoods and bridging infrastructure gaps.展开更多
BACKGROUND Proper antidepressant use can improve mood and reduce desire to drink alcohol in alcohol-induced-affective-disorder patients.Shugan Jieyu capsules(SJC)have various impacts on the central nervous system,prod...BACKGROUND Proper antidepressant use can improve mood and reduce desire to drink alcohol in alcohol-induced-affective-disorder patients.Shugan Jieyu capsules(SJC)have various impacts on the central nervous system,producing antidepressant effects.Traditional Chinese medicine(including Shugan Jieyu)is highly therapeutic in treating alcohol dependence,with few side-effects.However,research on its combination with Western antidepressants(e.g.,sertraline)to improve patients’depression is insufficient.AIM To evaluate the clinical efficacy and safety of SJC combined with sertraline vs sertraline monotherapy in alcohol-dependent patients with comorbid depression.METHODS We conducted a randomized,double-blind,placebo-controlled trial.Sixty patients(aged 18-65 years)were randomly assigned to two groups(n=30 per group).Primary outcome:Hamilton Depression Rating Scale(HAMD)-17 changes over 6 weeks.Benzodiazepines were permitted for severe insomnia.RESULTS The HAMD-17 score of the study(vs control)group was lower at treatment weeks 2,4,and 6(P<0.05).Regarding intra-group comparisons,the study group’s HAMD score was significantly lower than that before treatment from week 2(P<0.05),while that of the control group was significantly lower than that before treatment from week 4(P<0.05).The study and control groups’total efficacy rates were 90%and 73.3%,respectively,showing a significant difference in efficacy(χ^(2)=4.812,P=0.028).No significant difference was observed in adverse reactions’incidence between the groups at treatment weeks 2,4,and 6(P>0.05).CONCLUSION SJC-sertraline combination therapy accelerates depressive symptom relief(by 2 weeks)and improves response rates(+16.7%)in alcohol-dependent patients,without increasing adverse events.Clinical outcomes suggest potential synergistic mechanisms,though no biomarker analyses were performed.展开更多
In this study,we performed a systematic analysis of the multiplicity dependence of hadron production at mid-rapidity(|y|<0.5),ranging from the light to the charm sector in proton-proton(pp)collisions at√s=13 TeV.T...In this study,we performed a systematic analysis of the multiplicity dependence of hadron production at mid-rapidity(|y|<0.5),ranging from the light to the charm sector in proton-proton(pp)collisions at√s=13 TeV.This study used a multi-phase transport(AMPT)model coupled with PYTHIA8 initial conditions.We investigated the baryon-to-meson and the strange-to-non-strange meson ratios varying with the charged particle density.By tuning the coalescence parameters,the AMPT model provides a reasonable description of the experimental data for the inclusive production of both light and charm hadrons,comparable to the string fragmentation model calculations with color reconnection effects.Additionally,we analyzed the relative production of hadrons by examining the self-normalized particle ratios as a function of the charged hadron density.Our findings suggest that parton evolution effects and the coalescence hadronization process in the AMPT model result in a strong flavor hierarchy in the multiplicity dependence of the baryon-to-meson ratio.Furthermore,our investigation of the p_(T) differential double ratio of the baryon-to-meson fraction between high-and low-multiplicity events revealed distinct modifications to the flavor associated baryon-to-meson ratio p_(T) shape in high-multiplicity events when comparing the coalescence hadronization model to the color reconnection model.These observations highlight the importance of understanding the hadronization process in high-energy pp collisions through comprehensive multiplicity-dependent multi-flavor analysis.展开更多
Objective:Large-scale CRISPR screens have identified essential genes across cancer cell lines,but links between tumor functional properties and specific dependencies require investigation to reveal the mechanisms unde...Objective:Large-scale CRISPR screens have identified essential genes across cancer cell lines,but links between tumor functional properties and specific dependencies require investigation to reveal the mechanisms underlying dependencies and broaden understanding of targeted therapy.Methods:We selected 47 breast cancer cell lines from the Cancer Cell Line Encyclopedia(CCLE)with multi-omics data including gene dependency;somatic mutations;copy number alterations;and transcriptomic,proteomic,metabolomic,and methylation data.We established a dependency marker association(DMA)analytic pipeline by using linear regression modeling to assess associations between 3,874 representative gene dependencies and multi-omics markers.Additionally,we conducted non-negative matrix factorization clustering,to stratify breast cancer cell lines according to gene dependency features,and investigated cluster-specific DMAs.Results:We interpreted valuable DMAs according to two primary aspects.First,dependencies associated with gain-of-function alterations revealed addiction to lactate transporter SLC16A3,thus suggesting a promising therapeutic target.Second,dependencies associated with loss-of-function alterations included synthetic lethality(SL),collateral SL,and prioritized metabolic SL,encompassing paralog SL(e.g.,IMPDH1 and IMPDH2),single pathway SL(e.g.,GFPT1 and UAP1),and alternative pathway SL(e.g.,GPI and PGD).DMA analysis of the two clusters with divergent dependency signatures demonstrated that cluster1 cell lines exhibited extensive metabolism with mitochondrial protein dependencies,whereas cluster2 displays enhanced cell signaling,and reliance on DNA replication and membrane organelle regulators.Conclusions:We established a DMA analysis pipeline linking the gene dependencies of breast cancer cell lines to multi-omics characteristics,thus elucidating the underpinnings of tumor dependencies and offering a valuable resource for developing novel precision treatment strategies incorporating relevant markers.展开更多
Understanding interlayer charge transfer is crucial for elucidating interface interactions in heterostructures.As the layer number can significantly influence the interface coupling and band alignment,the charge trans...Understanding interlayer charge transfer is crucial for elucidating interface interactions in heterostructures.As the layer number can significantly influence the interface coupling and band alignment,the charge transfer behaviors can be largely regulated.Here,we constructed two-dimensional(2D)heterostructures consisting of monolayer WS_(2)and few-layer InSe to investigate the impact of InSe thickness on exciton dynamics.We performed photoluminescence(PL)spectroscopy and lifetime measurements on pristine few-layer InSe and the heterostructures with different InSe thicknesses.For pristine InSe layers,we found a non-monotonic layer dependence on PL lifetime,which can be attributed to the interplay between the indirect-to-direct bandgap transition and surface recombination effects.For heterostructures,we demonstrated that the type I band alignment of the heterostructure facilitates electron and hole transfer from monolayer WS_(2)to InSe.As the InSe layer number increases,the reduction in conduction band minimum(CBM)enhances the driving force for charge transfer,thereby improving the transfer efficiency.Furthermore,we fabricated and characterized a WS_(2)/InSe optoelectronic device.By analyzing bias voltage dependent PL spectra,we further demonstrated that the trions in WS_(2)within the heterostructure are positively charged(X^(+)),and their emission intensity can be efficiently modulated by applying different biases.This study not only reveals the layer-dependent characteristics of band alignment and interlayer charge transfer in heterostructures but also provides valuable insights for the applications of 2D semiconductors in optoelectronic devices.展开更多
OBJECTIVE:To observe the effect of different acupuncture frequencies on the abstinence rate which could be used as a reference for optimizing acupuncture cessation programs.METHODS:From July 2018 to June 2022,a total ...OBJECTIVE:To observe the effect of different acupuncture frequencies on the abstinence rate which could be used as a reference for optimizing acupuncture cessation programs.METHODS:From July 2018 to June 2022,a total of 220 smokers were recruited based on inclusion criteria and randomly divided into the high-frequency acupuncture group(HF group,n=110):5 times a week from the 1st to the 4th week,from weeks 5 to 8,three times a week and the low-frequency acupuncture group(LF group,n=110):3 times a week from the 1st to the 4th week,from weeks 5 to 8,twice a week,then treated for 8 weeks and followup at 1 month in Beijing.RESULTS:In total,162 subjects completed the whole study with a drop-out rate of 20.45%.The expiratory CO point abstinence rate was HF group 53/110(48.18%)vs LF group 41/110(37.27%)in Week 8(P=0.102)and HF group 46/110(41.82%)vs LF group 45/110(40.91%)in Week 12(P=0.891)and the HF acupuncture and LF acupuncture were nearly equal in the 8-week abstinence rate.In addition,both HF and LF acupuncture significantly reduced Fagerstr?m test for nicotine dependence scale(FTND)scores(P<0.05),Minnesota nicotine withdrawal scale(MNWS)scores(P<0.05),and Brief Questionnaire of Smoking Urges scale(QSU-Brief)scores(P<0.05),but HF acupuncture showed some superiority over LF acupuncture in relieving patients'smoking cravings(P<0.05).CONCLUSIONS:The study initially showed that both high-frequency acupuncture and low-frequency acupuncture treatment were safe and effective on smoking cessation for 8 weeks,but high-frequency acupuncture was advantageous in reducing smoking cravings.More accurate acupuncture frequency needs to be validated through larger clinical studies to optimize acupuncture smoking cessation programs.展开更多
Electrocatalysis has been investigated as a promising strategy to utilize green electricity to produce renewable fuels,valuable chemicals,and treat pollutants.Electrode kinetic analysis is a potent technique in interr...Electrocatalysis has been investigated as a promising strategy to utilize green electricity to produce renewable fuels,valuable chemicals,and treat pollutants.Electrode kinetic analysis is a potent technique in interrogating reaction mechanisms and evaluating the electrocatalysts.Electron transfer(ET)and proton‐coupled electron transfer(PCET)processes are widely present in reaction networks of electrocatalysis.pH dependence of the kinetics is frequently employed to evaluate whether an elementary step involves proton participation,which is determined by both the reversibility and the specific reactants of electrode reactions.In this article,we discuss the pH dependence of two widely used formulations of the Butler–Volmer kinetics for a model PCET step and highlight a potential pitfall in kinetic analysis.This work aims to provide guiding principles for distinguishing ET and PCET steps via kinetic measurements in electrolytes in a broad range pH values.展开更多
Nanomaterials have garnered recognition for their notable surface effects and demonstration of superior mechanical properties.Previous studies on the surface effects of nanomaterials,employing the finite element metho...Nanomaterials have garnered recognition for their notable surface effects and demonstration of superior mechanical properties.Previous studies on the surface effects of nanomaterials,employing the finite element method,often relied on simplified twodimensional models due to theoretical complexities.Consequently,these simplified models inadequately represent the mechanical properties of nanomaterials and fail to capture the substantial impact of surface effects,particularly the curvature dependence of nanosurfaces.This study applies the principle of minimum energy and leverages the Steigmann-Ogden surface theory of nanomaterials to formulate a novel finite element surface element that comprehensively accounts for surface effects.We conducted an analysis of the stress distribution and deformation characteristics of four typical 2D and 3D nanomaterial models.The accuracy of the developed surface element and finite element calculation method was verified through comparison with established references.The resulting finite element model provides a robust and compelling scientific approach for accurately predicting the mechanical performance of nanomaterials.展开更多
Most reliability studies assume large samples or independence among components,but these assump-tions often fail in practice,leading to imprecise inference.We address this issue by constructing confidence intervals(CI...Most reliability studies assume large samples or independence among components,but these assump-tions often fail in practice,leading to imprecise inference.We address this issue by constructing confidence intervals(CIs)for the reliability of two-component systems with Weibull distributed failure times under a copula-frailty framework.Our construction integrates gamma-distributed frailties to capture unobserved heterogeneity and a copula-based dependence structure for correlated failures.The main contribution of this work is to derive adjusted CIs that explicitly incorporate the copula parameter in the variance-covariance matrix,achieving near-nominal coverage probabilities even in small samples or highly dependent settings.Through simulation studies,we show that,although traditional methods may suffice with moderate dependence and large samples,the proposed CIs offer notable benefits when dependence is strong or data are sparse.We further illustrate our construction with a synthetic example illustrating how penalized estimation can mitigate the issue of a degenerate Hessian matrix under high dependence and limited observations,so enabling uncertainty quantification despite deviations from nominal assumptions.Overall,our results fill a gap in reliability modeling for systems prone to correlated failures,and contribute to more robust inference in engineering,industrial,and biomedical applications.展开更多
Background:With the proliferation of smartphones,adolescent mobile phone dependency has intensified,potentially precipitating academic burnout and other adverse outcomes among students.Contemporary study mostly examin...Background:With the proliferation of smartphones,adolescent mobile phone dependency has intensified,potentially precipitating academic burnout and other adverse outcomes among students.Contemporary study mostly examines college populations,resulting in a lack of exploration on the internal mechanisms connecting mobile phone dependency to academic burnout.In addition to analysing the chain-mediated effects of sleep quality and cognitive flexibility,this study sought to provide theoretical insights for prevention by applying the Conservation of Resources theory to examine the relationship between academic burnout and mobile phone dependency among middle and high school students.Methods:A cluster convenience sampling approach was adopted.Data were collected from 811 middle and high school students in Tianjin,China,using a paper-based questionnaire battery comprising the Mobile Phone Addiction Index,the Pittsburgh Sleep Quality Index,the Cognitive Flexibility Scale,and the Adolescent Academic Burnout Scale.Descriptive statistics and correlation analyses were conducted using SPSS 25.0.Chain mediation effects were examined via the PROCESS macro,with significance assessed using bias-corrected bootstrap 95%confidence intervals.Results:A statistically significant positive link exists between mobile phone dependency and academic burnout among middle and high school students(r=0.575,p<0.001).Dependence on mobile phones had a substantial direct impact on academic burnout(β=0.303,p<0.001).Chain mediation analysis revealed that mobile phone dependency had a substantial direct impact on academic burnout(β=0.303,p<0.001).Sleep quality and cognitive flexibility mediated the link between mobile phone dependency and academic burnout.These indirect pathways represent 44.18%of the total effect.Conclusions:Mobile phone dependency contributes to academic burnout amongmiddle and high school students,mediated sequentially by sleep quality and cognitive flexibility.These findings suggest a potential intervention strategy to mitigate academic burnout by targeting excessive mobile phone use,enhancing sleep hygiene,and implementing cognitive flexibility training.展开更多
Partial phase transformation in NiTi-based refrigerants usually enables efficient and durable elastocaloric cooling,but its thermomechanical behavior with varying temperatures remains unclear.Keeping this in view,the ...Partial phase transformation in NiTi-based refrigerants usually enables efficient and durable elastocaloric cooling,but its thermomechanical behavior with varying temperatures remains unclear.Keeping this in view,the elastocaloric effect of NiTi under incomplete transformation across 15-100℃ is investigated and a superelastic deformation window between 25 and 85℃ is identified.Synchronous infrared thermography and digital image correlation,and an innovative macro-micro phase-field model are employed to examine martensitic transformation and elastocaloric properties of NiTi within the superelastic window.Experimental and simulated results consistently reveal that the spatiotemporal thermal profiles correlate with Lüders strain band evolution.As superelastic deformation temperature increases,strain localization intensifies,with Lüders bands favoring an inward strain growth over an outward expansion,resulting in a smaller yet more deformed martensitic transformation zone.The aggravated strain inhomogeneity makes the local endothermic undercooling tested at 85℃ up to about twice(−30.05℃)that at 25℃(−15.32℃),boosting the global cooling capacity by 65%,despite constant strain.The seeming contradiction between the larger elastocaloric effect and the narrower apparent martensitic transformation zone is elucidated by recourse to the simulations.It is found that the martensitic transformation within the Lüders bands is incomplete,proceeding in a macroscopically uniform but microscopically heterogeneous manner.Elevated temperatures within the superelastic window increase the transformed volume fraction and enhance martensitic transformation,thereby strengthening the global caloric effect.The work sheds light on the interplay between partial martensitic transformation and thermal behavior in NiTi under varying superelastic deformation temperatures,providing insights for advanced elastocaloric cooling applications.展开更多
In the realm of video understanding,the demand for accurate and contextually rich video captioning has surged with the increasing volume and complexity of multimedia content.This research introduces an innovative solu...In the realm of video understanding,the demand for accurate and contextually rich video captioning has surged with the increasing volume and complexity of multimedia content.This research introduces an innovative solution for video captioning by integrating a Convolutional BiLSTM Convolutional Bidirectional Long Short-Term Memory(BiLSTM)constructed Variational Sequence-to-Sequence(CBVSS)approach.The proposed framework is adept at capturing intricate temporal dependencies within video sequences,enabling a more nuanced and contextually relevant description of dynamic scenes.However,optimizing its parameters for improved performance remains a crucial challenge.In response,in this research Golden Eagle Optimization(GEO)a metaheuristic optimization technique is used to fine-tune the Convolutional BiLSTM variational sequence-to-sequence model parameters.The application of GEO aims to enhancing the CBVSS ability to produce more exact and contextually rich video captions.The proposed attains an overall higher Recall of 59.75%and Precision of 63.78%for both datasets.Additionally,the proposed CBVSS method demonstrated superior performance across both datasets,achieving the highest METEOR(25.67)and CIDER(39.87)scores on the ActivityNet dataset,and further outperforming all compared models on the YouCook2 dataset with METEOR(28.67)and CIDER(43.02),highlighting its effectiveness in generating semantically rich and contextually accurate video captions.展开更多
Objective To identify prognostic genes associated with lysosome-dependent cell death(LDCD)in patients with gastric cancer(GC).Methods Differentially expressed genes(DEGs)were identified using The Cancer Genome Atlas-S...Objective To identify prognostic genes associated with lysosome-dependent cell death(LDCD)in patients with gastric cancer(GC).Methods Differentially expressed genes(DEGs)were identified using The Cancer Genome Atlas-Stomach Adenocarcinoma.Weighted gene co-expression network analysis was performed to identify the key module genes associated with LDCD score.Candidate genes were identified by DEGs and key module genes.Univariate Cox regression analysis,and least absolute shrinkage and selection operator regression and multivariate Cox regression analyses were performed for the selection of prognostic genes,and risk module was established.Subsequently,key cells were identified in the single-cell dataset(GSE183904),and prognostic gene expression was analyzed.Cell proliferation and migration were assessed using the Cell Counting Kit-8 assay and the wound healing assay.Results A total of 4,465 DEGs,95 candidate genes,and 4 prognostic genes,including C19orf59,BATF2,TNFAIP2,and TNFSF18,were identified in the analysis.Receiver operating characteristic curves indicated the excellent predictive power of the risk model.Three key cell types(B cells,chief cells,and endothelial/pericyte cells)were identified in the GSE183904 dataset.C19orf59 and TNFAIP2 exhibited predominant expression in macrophage species,whereas TNFAIP2 evolved over time in endothelial/pericyte cells and chief cells.Functional experiments confirmed that interfering with C19orf59 inhibited proliferation and migration in GC cells.Conclusion C19orf59,BATF2,TNFAIP2,and TNFSF18 are prognostic genes associated with LDCD in GC.Furthermore,the risk model established in this study showed robust predictive power.展开更多
New renewable energy exploitation technologies in offshore structures are vital for future energy production systems.Offshore hybrid wind-wave power generation(HWWPG)systems face increased component failure rates beca...New renewable energy exploitation technologies in offshore structures are vital for future energy production systems.Offshore hybrid wind-wave power generation(HWWPG)systems face increased component failure rates because of harsh weather,significantly affecting the maintenance procedures and reliability.Different types of failure rates of the wind turbine(WT)and wave energy converter(WEC),e.g.,the degradation and failure rates during regular wind speed fluctuation,the degradation and failure rates during intense wind speed fluctuation are considered.By incorporating both WT and WEC,the HWWPG system is designed to enhance the overall amount of electrical energy produced by the system over a given period under varying weather conditions.The universal generating function technique is used to calculate the HWWPG system dependability measures in a structured and efficient manner.This research highlights that intense weather conditions increase the failure rates of both WT and WEC,resulting in higher maintenance costs and more frequent downtimes,thus impacting the HWWPG system’s reliability.Although the HWWPG system can meet the energy demands in the presence of high failure rates,the reliance of the hybrid system on both WT and WEC helps maintain a relatively stable demand satisfaction during periods of high energy demand despite adverse weather conditions.To confirm the added value and applicability of the developed model,a case study of an offshore hybrid platform is conducted.The findings underscore the system’s robustness in maintaining energy production under varied weather conditions,though higher failure rates and maintenance costs arise in intense scenarios.展开更多
Objective:To evaluate the global liter-ature output on the relationship between brain-derived neurotrophic factor(BDNF)and cognitive function in al-cohol dependence syndrome using bibliometric methods and explore the ...Objective:To evaluate the global liter-ature output on the relationship between brain-derived neurotrophic factor(BDNF)and cognitive function in al-cohol dependence syndrome using bibliometric methods and explore the status and trends in this field.Method:The literature on the application of BDNF in cognitive impairment caused by alcohol dependence syndrome published from 1995 to 2023 were retrieved from Web of Science,and the relevant information(publication characteristics,country and institution,author,number of publications,citation,journal and research field,corresponding author,key words,etc.)was recorded.The bibliometrix R package was used for quantitative and qualitative analysis of publication output and author contributions.Result:A total of 99 articles were included.The overall number of publications in this field has increased over time.The countries and institutions that contributed the most to the field were the United States and the Academy of Medical Sciences of Iranian universities,respectively.Most of the authors were from the United States,followed by Spain,China,and Iran.Ceccanti M,Fiore M were the most productive authors.Publications with Ceccanti M had the highest h-index.The most cited reference author is Haenninen H(227 citations),and the number one published journal is Alcohol.Most articles were published in 2020(n=12)and 2022(n=11),followed by 2019 and 2021(n=10).The corresponding author has the largest number of publications from the United States,and more publications from a single country tend to have more cooperation from other countries.BDNF and alcohol appeared more frequently in various keyword clouds.However,significant differences remained in the author keyword cloud,keyword plus word cloud,and paper topic word cloud.Conclusion:BDNF has great potential in the application of cognitive dysfunction caused by alcohol dependence syndrome.Bibliometric methods and data visualization techniques can help understand the current state of research progress and enable relevant scholars and practitioners to predict the development trends in this field.展开更多
The post-fledging period, extending from fledging to independence, is a crucial life stage characterized by high mortality due to fledglings' limited mobility and inexperience. During this stage, fledglings gradua...The post-fledging period, extending from fledging to independence, is a crucial life stage characterized by high mortality due to fledglings' limited mobility and inexperience. During this stage, fledglings gradually increase their mobility, leave their parents, disperse from their natal site, and respond to the challenges of new environments. Characterizing these post-fledging movements and space use is essential for understanding juvenile survival strategies and devising targeted conservation measures. The Crested Ibis (Nipponia nippon), an endangered species and a highly protected animals at the national level in China, has seen limited research on its post-fledging movements and space use. From 2015 to 2023, we utilized biologgers, combined with field surveys, to study the movement and space use characteristics of 37 fledglings in Hanzhong City, Shaanxi Province, China, over a two-month post-fledging period. We quantified changes in activity levels (based on overall dynamic body acceleration), independence timing, onset of post-fledging dispersal, habitat selection, and daily activity rhythms after independence. Our results revealed individuals began independent living 26.23 ± 2.34 days post-fledging and onset of dispersal at 25.58 ± 2.33 days, with a range area at the natal of 2.08 ± 0.56 km^(2). The initial 30 days post-fledging are characterized as an ontogenetic phase marked by a rapid increase in body activity level. Fledglings preferred paddy fields during the independent period rather than the forests they relied on before independence. Interestingly, the daily activity rhythm, particularly foraging behavior, peaked at noon—contrasting with the expected morning and evening activity peaks—likely as an adaptation to avoid periods of peak human activity. Additionally, drowning, collisions, and predation in paddy fields are noteworthy causes of fledgling mortality. Consequently, we recommend protecting a 2-km^(2) area around the nest site for at least two-month post-fledging, implementing safety measures around power lines and cesspools. Additionally, reducing human disturbances near foraging habitats and expanding space within paddy fields would help mitigate survival pressures on fledglings.展开更多
文摘Background:This study aims to investigate the underlying mechanisms between parental marital conflict and adolescent short video dependence by constructing a chain mediation model,focusing on the mediating roles of experiential avoidance and emotional disturbance(anxiety,depression,and stress).Methods:Conducted in January 2025,the research recruited 4125 adolescents from multiple Chinese provinces through convenience sampling;after data cleaning,3957 valid participants(1959 males,1998 females)were included.Using a cross-sectional design,measures included parental marital conflict,experiential avoidance,anxiety,depression,stress,and short video dependence.Results:Pearson correlation analysis revealed significant positive correlations among all variables.Mediation analysis using the SPSS PROCESS macro showed that parental marital conflict directly predicted short video dependence(β=0.269,p<0.001),and also significantly predicted experiential avoidance(β=0.519,p<0.001),anxiety(β=0.072,p<0.001),depression(β=0.067,p<0.001),and stress(β=0.048,p<0.05).Experiential avoidance further predicted anxiety(β=0.521,p<0.001),depression(β=0.489,p<0.001),stress(β=0.408,p<0.001),and short video dependence(β=0.244,p<0.001).While both anxiety(β=0.050,p<0.05)and depression(β=0.116,p<0.001)positively predicted short video dependence,stress did not(β=0.019,p=0.257).Overall,experiential avoidance,anxiety,depression,and stress significantly mediated the relationship between parental marital conflict and short video dependence.Conclusion:These findings confirm that parental marital conflict not only directly influences adolescent short video dependence but also operates through a chain mediation pathway involving experiential avoidance and emotional disturbance,highlighting central psychological mechanisms and providing theoretical support for integrated mental health and behavioral interventions.
基金supported by the National Natural Science Foundation of China(32100773 and U20A6005)the National Science and Technology Innovation 2030-Major Project of China(2021ZD0202500)+4 种基金Shenzhen Medical Research Fund(B2402024)China Postdoctoral Science Foundation(2021M693296)Shenzhen Science and Technology Program(JCYJ20230807093815032)Guangdong High-level Hospital Construction Fund(ynkt2021-zz33 and LCYJ2022093)the Natural Science Foundation of Guangdong Province,China(2022A1515010297).
文摘Dear Editor,The Cay2.1 channel,also known as the P/Q-type Ca^(2+) channel,is a particular type of voltage-gated Ca^(2+) channel primarily expressed on the presynaptic membrane in the brain[1].It serves as an essential part of the precisely orchestrated neurotransmitter release machinery.
文摘Supported metal catalysts are the backbone of heterogeneous catalysis,playing a crucial role in the modern chemical industry.Metal-support interactions(MSIs)are known important in determining the catalytic performance of supported metal catalysts.This is particularly true for single-atom catalysts(SACs)and pseudo-single-atom catalysts(pseudo-SACs),where all metal atoms are dispersed on,and interact directly with the support.Consequently,the MSI of SACs and pseudo-SACs are theoretically more sensitive to modulation compared to that of traditional nanoparticle catalysts.In this work,we experimentally demonstrated this hypothesis by an observed size-dependent MSI modulation.We fabricated CoFe_(2)O_(4) supported Pt pseudo-SACs and nanoparticle catalysts,followed by a straightforward water treatment process.It was found that the covalent strong metal-support interaction(CMSI)in pseudo-SACs can be weakened,leading to a significant activity improvement in methane combustion reaction.This finding aligns with our recent observation of CoFe_(2)O_(4) supported Pt SACs.By contrast,the MSI in Pt nanoparticle catalyst was barely affected by the water treatment,giving rise to almost unchanged catalytic performance.This work highlights the critical role of metal size in determining the MSI modulation,offering a novel strategy for tuning the catalytic performance of SACs and pseudo-SACs by fine-tuning their MSIs.
基金supported by the National Social Science Fundation(Grant No.21BTJ040)the Project of Outstanding Young People in University of Anhui Province(Grant Nos.2023AH020037,SLXY2024A001).
文摘In this paper,by utilizing the Marcinkiewicz-Zygmund inequality and Rosenthal-type inequality of negatively superadditive dependent(NSD)random arrays and truncated method,we investigate the complete f-moment convergence of NSD random variables.We establish and improve a general result on the complete f-moment convergence for Sung’s type randomly weighted sums of NSD random variables under some general assumptions.As an application,we show the complete consistency for the randomly weighted estimator in a nonparametric regression model based on NSD errors.
文摘Rural communities in developing countries often struggle with resource dependency,economic challenges,and poor infrastructure,and villages in Uttarakhand,India,are no exception.This study aims to examine the socioeconomic factors influencing forest conservation,assess livelihood dependency on forest resources,and evaluate how socioeconomic status shapes sustainable forest management in Shishambara and Buddhi villages in Dehradun.The study employed purposive and random sampling covering 10%of households,using structured surveys,interviews,field observations,market surveys,and focus group discussions.The survey reveals an agriculture-dominated livelihood,engaging 60%in Buddhi and 65%in Shishambara,alongside private-sector jobs and daily wage labour.Literacy rates differ significantly,with Buddhi at 72%and Shishambara at 58%.Despite accessibility to LPG connections,traditional cooking fuels like fuelwood and cow dung remain predominant,utilized by 70%of households in Buddhi and 75%in Shishambara.Most homes are Pakka,yet only 18.8%in Buddhi and 22%in Shishambara have toilets.Public transport is scarce,leaving villagers reliant on private vehicles.These findings underscore the need for policies that address resource management,improve basic services,and support sustainable development,offering a road map for uplifting rural livelihoods and bridging infrastructure gaps.
文摘BACKGROUND Proper antidepressant use can improve mood and reduce desire to drink alcohol in alcohol-induced-affective-disorder patients.Shugan Jieyu capsules(SJC)have various impacts on the central nervous system,producing antidepressant effects.Traditional Chinese medicine(including Shugan Jieyu)is highly therapeutic in treating alcohol dependence,with few side-effects.However,research on its combination with Western antidepressants(e.g.,sertraline)to improve patients’depression is insufficient.AIM To evaluate the clinical efficacy and safety of SJC combined with sertraline vs sertraline monotherapy in alcohol-dependent patients with comorbid depression.METHODS We conducted a randomized,double-blind,placebo-controlled trial.Sixty patients(aged 18-65 years)were randomly assigned to two groups(n=30 per group).Primary outcome:Hamilton Depression Rating Scale(HAMD)-17 changes over 6 weeks.Benzodiazepines were permitted for severe insomnia.RESULTS The HAMD-17 score of the study(vs control)group was lower at treatment weeks 2,4,and 6(P<0.05).Regarding intra-group comparisons,the study group’s HAMD score was significantly lower than that before treatment from week 2(P<0.05),while that of the control group was significantly lower than that before treatment from week 4(P<0.05).The study and control groups’total efficacy rates were 90%and 73.3%,respectively,showing a significant difference in efficacy(χ^(2)=4.812,P=0.028).No significant difference was observed in adverse reactions’incidence between the groups at treatment weeks 2,4,and 6(P>0.05).CONCLUSION SJC-sertraline combination therapy accelerates depressive symptom relief(by 2 weeks)and improves response rates(+16.7%)in alcohol-dependent patients,without increasing adverse events.Clinical outcomes suggest potential synergistic mechanisms,though no biomarker analyses were performed.
基金supported by the National Natural Science Foundation of China(Nos.12205259 and 12147101)the Fundamental Research Funds for the Central Universities,China University of Geosciences(Wuhan)with No.G1323523064.
文摘In this study,we performed a systematic analysis of the multiplicity dependence of hadron production at mid-rapidity(|y|<0.5),ranging from the light to the charm sector in proton-proton(pp)collisions at√s=13 TeV.This study used a multi-phase transport(AMPT)model coupled with PYTHIA8 initial conditions.We investigated the baryon-to-meson and the strange-to-non-strange meson ratios varying with the charged particle density.By tuning the coalescence parameters,the AMPT model provides a reasonable description of the experimental data for the inclusive production of both light and charm hadrons,comparable to the string fragmentation model calculations with color reconnection effects.Additionally,we analyzed the relative production of hadrons by examining the self-normalized particle ratios as a function of the charged hadron density.Our findings suggest that parton evolution effects and the coalescence hadronization process in the AMPT model result in a strong flavor hierarchy in the multiplicity dependence of the baryon-to-meson ratio.Furthermore,our investigation of the p_(T) differential double ratio of the baryon-to-meson fraction between high-and low-multiplicity events revealed distinct modifications to the flavor associated baryon-to-meson ratio p_(T) shape in high-multiplicity events when comparing the coalescence hadronization model to the color reconnection model.These observations highlight the importance of understanding the hadronization process in high-energy pp collisions through comprehensive multiplicity-dependent multi-flavor analysis.
基金supported by grants from the National Key Research and Development Project of China(Grant No.2020YFA0112304)the National Natural Science Foundation of China(Grant Nos.91959207 and 82202883).
文摘Objective:Large-scale CRISPR screens have identified essential genes across cancer cell lines,but links between tumor functional properties and specific dependencies require investigation to reveal the mechanisms underlying dependencies and broaden understanding of targeted therapy.Methods:We selected 47 breast cancer cell lines from the Cancer Cell Line Encyclopedia(CCLE)with multi-omics data including gene dependency;somatic mutations;copy number alterations;and transcriptomic,proteomic,metabolomic,and methylation data.We established a dependency marker association(DMA)analytic pipeline by using linear regression modeling to assess associations between 3,874 representative gene dependencies and multi-omics markers.Additionally,we conducted non-negative matrix factorization clustering,to stratify breast cancer cell lines according to gene dependency features,and investigated cluster-specific DMAs.Results:We interpreted valuable DMAs according to two primary aspects.First,dependencies associated with gain-of-function alterations revealed addiction to lactate transporter SLC16A3,thus suggesting a promising therapeutic target.Second,dependencies associated with loss-of-function alterations included synthetic lethality(SL),collateral SL,and prioritized metabolic SL,encompassing paralog SL(e.g.,IMPDH1 and IMPDH2),single pathway SL(e.g.,GFPT1 and UAP1),and alternative pathway SL(e.g.,GPI and PGD).DMA analysis of the two clusters with divergent dependency signatures demonstrated that cluster1 cell lines exhibited extensive metabolism with mitochondrial protein dependencies,whereas cluster2 displays enhanced cell signaling,and reliance on DNA replication and membrane organelle regulators.Conclusions:We established a DMA analysis pipeline linking the gene dependencies of breast cancer cell lines to multi-omics characteristics,thus elucidating the underpinnings of tumor dependencies and offering a valuable resource for developing novel precision treatment strategies incorporating relevant markers.
基金supported by the National Natural Science Foundation of China(Grant Nos.92263107,U23A20570,52221001,62090035,and 52022029)the Hunan Provincial Natural Science Foundation of China(Grant No.2024RC1034)。
文摘Understanding interlayer charge transfer is crucial for elucidating interface interactions in heterostructures.As the layer number can significantly influence the interface coupling and band alignment,the charge transfer behaviors can be largely regulated.Here,we constructed two-dimensional(2D)heterostructures consisting of monolayer WS_(2)and few-layer InSe to investigate the impact of InSe thickness on exciton dynamics.We performed photoluminescence(PL)spectroscopy and lifetime measurements on pristine few-layer InSe and the heterostructures with different InSe thicknesses.For pristine InSe layers,we found a non-monotonic layer dependence on PL lifetime,which can be attributed to the interplay between the indirect-to-direct bandgap transition and surface recombination effects.For heterostructures,we demonstrated that the type I band alignment of the heterostructure facilitates electron and hole transfer from monolayer WS_(2)to InSe.As the InSe layer number increases,the reduction in conduction band minimum(CBM)enhances the driving force for charge transfer,thereby improving the transfer efficiency.Furthermore,we fabricated and characterized a WS_(2)/InSe optoelectronic device.By analyzing bias voltage dependent PL spectra,we further demonstrated that the trions in WS_(2)within the heterostructure are positively charged(X^(+)),and their emission intensity can be efficiently modulated by applying different biases.This study not only reveals the layer-dependent characteristics of band alignment and interlayer charge transfer in heterostructures but also provides valuable insights for the applications of 2D semiconductors in optoelectronic devices.
基金the Fund of Science and Technology Innovation Project of Chinese Academy of Chinese Medical Sciences Project:Self-service Acupuncture Smoking Cessation Research and Development(No.CI2021A03506)Fund of Capital Health Development Special Research Project:Research on Development and Clinical Applicalion of Wrist Acupuncture Smoking Cessation Instrument(No.2022-1-4281)。
文摘OBJECTIVE:To observe the effect of different acupuncture frequencies on the abstinence rate which could be used as a reference for optimizing acupuncture cessation programs.METHODS:From July 2018 to June 2022,a total of 220 smokers were recruited based on inclusion criteria and randomly divided into the high-frequency acupuncture group(HF group,n=110):5 times a week from the 1st to the 4th week,from weeks 5 to 8,three times a week and the low-frequency acupuncture group(LF group,n=110):3 times a week from the 1st to the 4th week,from weeks 5 to 8,twice a week,then treated for 8 weeks and followup at 1 month in Beijing.RESULTS:In total,162 subjects completed the whole study with a drop-out rate of 20.45%.The expiratory CO point abstinence rate was HF group 53/110(48.18%)vs LF group 41/110(37.27%)in Week 8(P=0.102)and HF group 46/110(41.82%)vs LF group 45/110(40.91%)in Week 12(P=0.891)and the HF acupuncture and LF acupuncture were nearly equal in the 8-week abstinence rate.In addition,both HF and LF acupuncture significantly reduced Fagerstr?m test for nicotine dependence scale(FTND)scores(P<0.05),Minnesota nicotine withdrawal scale(MNWS)scores(P<0.05),and Brief Questionnaire of Smoking Urges scale(QSU-Brief)scores(P<0.05),but HF acupuncture showed some superiority over LF acupuncture in relieving patients'smoking cravings(P<0.05).CONCLUSIONS:The study initially showed that both high-frequency acupuncture and low-frequency acupuncture treatment were safe and effective on smoking cessation for 8 weeks,but high-frequency acupuncture was advantageous in reducing smoking cravings.More accurate acupuncture frequency needs to be validated through larger clinical studies to optimize acupuncture smoking cessation programs.
基金supported by the Beijing Natural Science Foundation Key Research Program(Grant Z240026)the Beijing National Laboratory for Molecular Sciences.
文摘Electrocatalysis has been investigated as a promising strategy to utilize green electricity to produce renewable fuels,valuable chemicals,and treat pollutants.Electrode kinetic analysis is a potent technique in interrogating reaction mechanisms and evaluating the electrocatalysts.Electron transfer(ET)and proton‐coupled electron transfer(PCET)processes are widely present in reaction networks of electrocatalysis.pH dependence of the kinetics is frequently employed to evaluate whether an elementary step involves proton participation,which is determined by both the reversibility and the specific reactants of electrode reactions.In this article,we discuss the pH dependence of two widely used formulations of the Butler–Volmer kinetics for a model PCET step and highlight a potential pitfall in kinetic analysis.This work aims to provide guiding principles for distinguishing ET and PCET steps via kinetic measurements in electrolytes in a broad range pH values.
基金supported by the Jiangsu Funding Program for Excellent Postdoctoral Talent (Grant No.2023ZB397)the Project funded by China Postdoctoral Science Foundation (Grant No.2023M732986).
文摘Nanomaterials have garnered recognition for their notable surface effects and demonstration of superior mechanical properties.Previous studies on the surface effects of nanomaterials,employing the finite element method,often relied on simplified twodimensional models due to theoretical complexities.Consequently,these simplified models inadequately represent the mechanical properties of nanomaterials and fail to capture the substantial impact of surface effects,particularly the curvature dependence of nanosurfaces.This study applies the principle of minimum energy and leverages the Steigmann-Ogden surface theory of nanomaterials to formulate a novel finite element surface element that comprehensively accounts for surface effects.We conducted an analysis of the stress distribution and deformation characteristics of four typical 2D and 3D nanomaterial models.The accuracy of the developed surface element and finite element calculation method was verified through comparison with established references.The resulting finite element model provides a robust and compelling scientific approach for accurately predicting the mechanical performance of nanomaterials.
基金supported by the Colombian government through COLCIENCIA scholarships,National Doctoral Program,Call 727 of 2015C.Castro gratefully acknowledges partial financial support from the Centro de Matematica da Universidade do Minho(CMAT/UM),through UID/00013V.Leiva acknowledges funding from the Agencia Nacional de Investigacion y Desarrollo(ANID)of the Chilean Ministry of Science,Technology,Knowledge and Innovation,through FONDECYT project grant 1200525.
文摘Most reliability studies assume large samples or independence among components,but these assump-tions often fail in practice,leading to imprecise inference.We address this issue by constructing confidence intervals(CIs)for the reliability of two-component systems with Weibull distributed failure times under a copula-frailty framework.Our construction integrates gamma-distributed frailties to capture unobserved heterogeneity and a copula-based dependence structure for correlated failures.The main contribution of this work is to derive adjusted CIs that explicitly incorporate the copula parameter in the variance-covariance matrix,achieving near-nominal coverage probabilities even in small samples or highly dependent settings.Through simulation studies,we show that,although traditional methods may suffice with moderate dependence and large samples,the proposed CIs offer notable benefits when dependence is strong or data are sparse.We further illustrate our construction with a synthetic example illustrating how penalized estimation can mitigate the issue of a degenerate Hessian matrix under high dependence and limited observations,so enabling uncertainty quantification despite deviations from nominal assumptions.Overall,our results fill a gap in reliability modeling for systems prone to correlated failures,and contribute to more robust inference in engineering,industrial,and biomedical applications.
基金supported by the Philosophy and Social Sciences Planning Foundation of Tianjin(Grant No.TJJX22-006).
文摘Background:With the proliferation of smartphones,adolescent mobile phone dependency has intensified,potentially precipitating academic burnout and other adverse outcomes among students.Contemporary study mostly examines college populations,resulting in a lack of exploration on the internal mechanisms connecting mobile phone dependency to academic burnout.In addition to analysing the chain-mediated effects of sleep quality and cognitive flexibility,this study sought to provide theoretical insights for prevention by applying the Conservation of Resources theory to examine the relationship between academic burnout and mobile phone dependency among middle and high school students.Methods:A cluster convenience sampling approach was adopted.Data were collected from 811 middle and high school students in Tianjin,China,using a paper-based questionnaire battery comprising the Mobile Phone Addiction Index,the Pittsburgh Sleep Quality Index,the Cognitive Flexibility Scale,and the Adolescent Academic Burnout Scale.Descriptive statistics and correlation analyses were conducted using SPSS 25.0.Chain mediation effects were examined via the PROCESS macro,with significance assessed using bias-corrected bootstrap 95%confidence intervals.Results:A statistically significant positive link exists between mobile phone dependency and academic burnout among middle and high school students(r=0.575,p<0.001).Dependence on mobile phones had a substantial direct impact on academic burnout(β=0.303,p<0.001).Chain mediation analysis revealed that mobile phone dependency had a substantial direct impact on academic burnout(β=0.303,p<0.001).Sleep quality and cognitive flexibility mediated the link between mobile phone dependency and academic burnout.These indirect pathways represent 44.18%of the total effect.Conclusions:Mobile phone dependency contributes to academic burnout amongmiddle and high school students,mediated sequentially by sleep quality and cognitive flexibility.These findings suggest a potential intervention strategy to mitigate academic burnout by targeting excessive mobile phone use,enhancing sleep hygiene,and implementing cognitive flexibility training.
基金financially supported by the National Key Re-search and Development Program of China(No.2017YFB0701801)。
文摘Partial phase transformation in NiTi-based refrigerants usually enables efficient and durable elastocaloric cooling,but its thermomechanical behavior with varying temperatures remains unclear.Keeping this in view,the elastocaloric effect of NiTi under incomplete transformation across 15-100℃ is investigated and a superelastic deformation window between 25 and 85℃ is identified.Synchronous infrared thermography and digital image correlation,and an innovative macro-micro phase-field model are employed to examine martensitic transformation and elastocaloric properties of NiTi within the superelastic window.Experimental and simulated results consistently reveal that the spatiotemporal thermal profiles correlate with Lüders strain band evolution.As superelastic deformation temperature increases,strain localization intensifies,with Lüders bands favoring an inward strain growth over an outward expansion,resulting in a smaller yet more deformed martensitic transformation zone.The aggravated strain inhomogeneity makes the local endothermic undercooling tested at 85℃ up to about twice(−30.05℃)that at 25℃(−15.32℃),boosting the global cooling capacity by 65%,despite constant strain.The seeming contradiction between the larger elastocaloric effect and the narrower apparent martensitic transformation zone is elucidated by recourse to the simulations.It is found that the martensitic transformation within the Lüders bands is incomplete,proceeding in a macroscopically uniform but microscopically heterogeneous manner.Elevated temperatures within the superelastic window increase the transformed volume fraction and enhance martensitic transformation,thereby strengthening the global caloric effect.The work sheds light on the interplay between partial martensitic transformation and thermal behavior in NiTi under varying superelastic deformation temperatures,providing insights for advanced elastocaloric cooling applications.
文摘In the realm of video understanding,the demand for accurate and contextually rich video captioning has surged with the increasing volume and complexity of multimedia content.This research introduces an innovative solution for video captioning by integrating a Convolutional BiLSTM Convolutional Bidirectional Long Short-Term Memory(BiLSTM)constructed Variational Sequence-to-Sequence(CBVSS)approach.The proposed framework is adept at capturing intricate temporal dependencies within video sequences,enabling a more nuanced and contextually relevant description of dynamic scenes.However,optimizing its parameters for improved performance remains a crucial challenge.In response,in this research Golden Eagle Optimization(GEO)a metaheuristic optimization technique is used to fine-tune the Convolutional BiLSTM variational sequence-to-sequence model parameters.The application of GEO aims to enhancing the CBVSS ability to produce more exact and contextually rich video captions.The proposed attains an overall higher Recall of 59.75%and Precision of 63.78%for both datasets.Additionally,the proposed CBVSS method demonstrated superior performance across both datasets,achieving the highest METEOR(25.67)and CIDER(39.87)scores on the ActivityNet dataset,and further outperforming all compared models on the YouCook2 dataset with METEOR(28.67)and CIDER(43.02),highlighting its effectiveness in generating semantically rich and contextually accurate video captions.
基金supported by Hainan Provincial Natural Science Foundation of China(No.820CXTD438)National Natural Science Foundation of China(No.82160634, No.81773495)。
文摘Objective To identify prognostic genes associated with lysosome-dependent cell death(LDCD)in patients with gastric cancer(GC).Methods Differentially expressed genes(DEGs)were identified using The Cancer Genome Atlas-Stomach Adenocarcinoma.Weighted gene co-expression network analysis was performed to identify the key module genes associated with LDCD score.Candidate genes were identified by DEGs and key module genes.Univariate Cox regression analysis,and least absolute shrinkage and selection operator regression and multivariate Cox regression analyses were performed for the selection of prognostic genes,and risk module was established.Subsequently,key cells were identified in the single-cell dataset(GSE183904),and prognostic gene expression was analyzed.Cell proliferation and migration were assessed using the Cell Counting Kit-8 assay and the wound healing assay.Results A total of 4,465 DEGs,95 candidate genes,and 4 prognostic genes,including C19orf59,BATF2,TNFAIP2,and TNFSF18,were identified in the analysis.Receiver operating characteristic curves indicated the excellent predictive power of the risk model.Three key cell types(B cells,chief cells,and endothelial/pericyte cells)were identified in the GSE183904 dataset.C19orf59 and TNFAIP2 exhibited predominant expression in macrophage species,whereas TNFAIP2 evolved over time in endothelial/pericyte cells and chief cells.Functional experiments confirmed that interfering with C19orf59 inhibited proliferation and migration in GC cells.Conclusion C19orf59,BATF2,TNFAIP2,and TNFSF18 are prognostic genes associated with LDCD in GC.Furthermore,the risk model established in this study showed robust predictive power.
文摘New renewable energy exploitation technologies in offshore structures are vital for future energy production systems.Offshore hybrid wind-wave power generation(HWWPG)systems face increased component failure rates because of harsh weather,significantly affecting the maintenance procedures and reliability.Different types of failure rates of the wind turbine(WT)and wave energy converter(WEC),e.g.,the degradation and failure rates during regular wind speed fluctuation,the degradation and failure rates during intense wind speed fluctuation are considered.By incorporating both WT and WEC,the HWWPG system is designed to enhance the overall amount of electrical energy produced by the system over a given period under varying weather conditions.The universal generating function technique is used to calculate the HWWPG system dependability measures in a structured and efficient manner.This research highlights that intense weather conditions increase the failure rates of both WT and WEC,resulting in higher maintenance costs and more frequent downtimes,thus impacting the HWWPG system’s reliability.Although the HWWPG system can meet the energy demands in the presence of high failure rates,the reliance of the hybrid system on both WT and WEC helps maintain a relatively stable demand satisfaction during periods of high energy demand despite adverse weather conditions.To confirm the added value and applicability of the developed model,a case study of an offshore hybrid platform is conducted.The findings underscore the system’s robustness in maintaining energy production under varied weather conditions,though higher failure rates and maintenance costs arise in intense scenarios.
基金supported by grants from the Scientific Research Fund project of Education Department of Yunnan Province(2024J0314)Joint Special Project on Basic Research of Yunnan Provincial Department of Science and Technology and Kunming Medical University(202501AY070001-206).
文摘Objective:To evaluate the global liter-ature output on the relationship between brain-derived neurotrophic factor(BDNF)and cognitive function in al-cohol dependence syndrome using bibliometric methods and explore the status and trends in this field.Method:The literature on the application of BDNF in cognitive impairment caused by alcohol dependence syndrome published from 1995 to 2023 were retrieved from Web of Science,and the relevant information(publication characteristics,country and institution,author,number of publications,citation,journal and research field,corresponding author,key words,etc.)was recorded.The bibliometrix R package was used for quantitative and qualitative analysis of publication output and author contributions.Result:A total of 99 articles were included.The overall number of publications in this field has increased over time.The countries and institutions that contributed the most to the field were the United States and the Academy of Medical Sciences of Iranian universities,respectively.Most of the authors were from the United States,followed by Spain,China,and Iran.Ceccanti M,Fiore M were the most productive authors.Publications with Ceccanti M had the highest h-index.The most cited reference author is Haenninen H(227 citations),and the number one published journal is Alcohol.Most articles were published in 2020(n=12)and 2022(n=11),followed by 2019 and 2021(n=10).The corresponding author has the largest number of publications from the United States,and more publications from a single country tend to have more cooperation from other countries.BDNF and alcohol appeared more frequently in various keyword clouds.However,significant differences remained in the author keyword cloud,keyword plus word cloud,and paper topic word cloud.Conclusion:BDNF has great potential in the application of cognitive dysfunction caused by alcohol dependence syndrome.Bibliometric methods and data visualization techniques can help understand the current state of research progress and enable relevant scholars and practitioners to predict the development trends in this field.
基金funded by the National Natural Science Foundation of China(No.32270554,32400400).
文摘The post-fledging period, extending from fledging to independence, is a crucial life stage characterized by high mortality due to fledglings' limited mobility and inexperience. During this stage, fledglings gradually increase their mobility, leave their parents, disperse from their natal site, and respond to the challenges of new environments. Characterizing these post-fledging movements and space use is essential for understanding juvenile survival strategies and devising targeted conservation measures. The Crested Ibis (Nipponia nippon), an endangered species and a highly protected animals at the national level in China, has seen limited research on its post-fledging movements and space use. From 2015 to 2023, we utilized biologgers, combined with field surveys, to study the movement and space use characteristics of 37 fledglings in Hanzhong City, Shaanxi Province, China, over a two-month post-fledging period. We quantified changes in activity levels (based on overall dynamic body acceleration), independence timing, onset of post-fledging dispersal, habitat selection, and daily activity rhythms after independence. Our results revealed individuals began independent living 26.23 ± 2.34 days post-fledging and onset of dispersal at 25.58 ± 2.33 days, with a range area at the natal of 2.08 ± 0.56 km^(2). The initial 30 days post-fledging are characterized as an ontogenetic phase marked by a rapid increase in body activity level. Fledglings preferred paddy fields during the independent period rather than the forests they relied on before independence. Interestingly, the daily activity rhythm, particularly foraging behavior, peaked at noon—contrasting with the expected morning and evening activity peaks—likely as an adaptation to avoid periods of peak human activity. Additionally, drowning, collisions, and predation in paddy fields are noteworthy causes of fledgling mortality. Consequently, we recommend protecting a 2-km^(2) area around the nest site for at least two-month post-fledging, implementing safety measures around power lines and cesspools. Additionally, reducing human disturbances near foraging habitats and expanding space within paddy fields would help mitigate survival pressures on fledglings.
