Delayed wound healing following radical gastrectomy remains an important yet underappreciated complication that prolongs hospitalization,increases costs,and undermines patient recovery.In An et al’s recent study,the ...Delayed wound healing following radical gastrectomy remains an important yet underappreciated complication that prolongs hospitalization,increases costs,and undermines patient recovery.In An et al’s recent study,the authors present a machine learning-based risk prediction approach using routinely available clinical and laboratory parameters.Among the evaluated algorithms,a decision tree model demonstrated excellent discrimination,achieving an area under the curve of 0.951 in the validation set and notably identifying all true cases of delayed wound healing at the Youden index threshold.The inclusion of variables such as drainage duration,preoperative white blood cell and neutrophil counts,alongside age and sex,highlights the pragmatic appeal of the model for early postoperative monitoring.Nevertheless,several aspects warrant critical reflection,including the reliance on a postoperative variable(drainage duration),internal validation only,and certain reporting inconsistencies.This letter underscores both the promise and the limitations of adopting interpretable machine learning models in perioperative care.We advocate for transparent reporting,external validation,and careful consideration of clinically actionable timepoints before integration into practice.Ultimately,this work represents a valuable step toward precision risk stratification in gastric cancer surgery,and sets the stage for multicenter,prospective evaluations.展开更多
This study examines the methods to plan the development of offshore oilfields over the years,which are used to support the decision-making on the development of offshore oilfields.About 100 papers are analysed and cat...This study examines the methods to plan the development of offshore oilfields over the years,which are used to support the decision-making on the development of offshore oilfields.About 100 papers are analysed and categorised into different groups of main early-stage decisions.The present study stands in contrast to the contributions of the operations research and system engineering review articles,on the one hand,and the petroleum engineering review articles,on the other.This is because it does not focus on one methodological approach,nor does it limit the literature analysis by offshore oilfield characteristics.Consequently,the present analysis may offer valuable insights,for instance,by identifying environmental planning decisions as a recent yet highly significant concern that is currently being imposed on decision-making process.Thus,it is evident that the incorporation of safety criteria within the technical-economic decision-making process for the design of production systems would be a crucial requirement at development phase.展开更多
Across four studies,we explore the impact of solitude on consumers’reliance on feelings versus reasons in decision making,along with the underlying mechanism and boundary conditions.The results indicate that solitude...Across four studies,we explore the impact of solitude on consumers’reliance on feelings versus reasons in decision making,along with the underlying mechanism and boundary conditions.The results indicate that solitude individuals(vs.non-solitude)would prefer feeling-based strategy in decision-making,resulting in a higher intention of choosing the affectively superior option over the cognitively superior option(Study 1).Self-focus plays the underlying mechanism in the solitude effect(Study 2).Moreover,we also examine two boundary conditions:motivation(Study 3)and temporal orientation(Study 4),which indicates that involuntary motivation and future orientation can mitigate the solitude effect on affective processing.These findings provide insights into consumers’judgments of product attributes and selection of decision-making strategies according to their situations.展开更多
Higher education institutions are becoming increasingly concerned with the retention of their students.This work is motivated by the interest in predicting and reducing student dropout,and consequently in reducing the...Higher education institutions are becoming increasingly concerned with the retention of their students.This work is motivated by the interest in predicting and reducing student dropout,and consequently in reducing the financial losses of said institutions.Based on the characterization of the dropout problem and the application of a knowledge discovery process,an ensemble model is proposed to improve dropout prediction.The ensemble model combines the results of three models:logistic regression,neural networks,and decision tree.As a result,the model can correctly classify 89%of the students as enrolled or dropped and accurately identify 98.1%of dropouts.When compared with the Random Forest ensemble method,the proposed model demonstrates desirable characteristics to assist management in proposing actions to retain students.展开更多
Effective wildland fire management requires real-time access to comprehensive and distilled information from different data sources.The Digital Twin technology becomes a promising tool in optimizing the processes of w...Effective wildland fire management requires real-time access to comprehensive and distilled information from different data sources.The Digital Twin technology becomes a promising tool in optimizing the processes of wildfire pre-vention,monitoring,disaster response,and post-fire recovery.This review examines the potential utility of Digital Twin in wildfire management and aims to inspire further exploration and experimentation by researchers and practitioners in the fields of environment,forestry,fire ecology,and firefighting services.By creating virtual replicas of wildfire in the physical world,a Digital Twin platform facilitates data integration from multiple sources,such as remote sensing,weather forecast-ing,and ground-based sensors,providing a holistic view of emergency response and decision-making.Furthermore,Digital Twin can support simulation-based training and scenario testing for prescribed fire planning and firefighting to improve preparedness and response to evacuation and rescue.Successful applications of Digital Twin in wildfire management require horizontal collaboration among researchers,practitioners,and stakeholders,as well as enhanced resource sharing and data exchange.This review seeks a deeper understanding of future wildland fire management from a technological perspective and inspiration of future research and implementation.Further research should focus on refining and validating Digital Twin models and the integration into existing fire management operations,and then demonstrating them in real wildland fires.展开更多
Traditional Chinese medicine(TCM)represents a paradigmatic approach to personalized medicine,developed through the systematic accumulation and refinement of clinical empirical data over more than 2000 years,and now en...Traditional Chinese medicine(TCM)represents a paradigmatic approach to personalized medicine,developed through the systematic accumulation and refinement of clinical empirical data over more than 2000 years,and now encompasses large-scale electronic medical records(EMR)and experimental molecular data.Artificial intelligence(AI)has demonstrated its utility in medicine through the development of various expert systems(e.g.,MYCIN)since the 1970s.With the emergence of deep learning and large language models(LLMs),AI’s potential in medicine shows considerable promise.Consequently,the integration of AI and TCM from both clinical and scientific perspectives presents a fundamental and promising research direction.This survey provides an insightful overview of TCM AI research,summarizing related research tasks from three perspectives:systems-level biological mechanism elucidation,real-world clinical evidence inference,and personalized clinical decision support.The review highlights representative AI methodologies alongside their applications in both TCM scientific inquiry and clinical practice.To critically assess the current state of the field,this work identifies major challenges and opportunities that constrain the development of robust research capabilities—particularly in the mechanistic understanding of TCM syndromes and herbal formulations,novel drug discovery,and the delivery of high-quality,patient-centered clinical care.The findings underscore that future advancements in AI-driven TCM research will rely on the development of high-quality,large-scale data repositories;the construction of comprehensive and domain-specific knowledge graphs(KGs);deeper insights into the biological mechanisms underpinning clinical efficacy;rigorous causal inference frameworks;and intelligent,personalized decision support systems.展开更多
The complex pathophysiology and diverse manifestations of esophageal disorders pose challenges in clinical practice,particularly in achieving accurate early diagnosis and risk stratification.While traditional approach...The complex pathophysiology and diverse manifestations of esophageal disorders pose challenges in clinical practice,particularly in achieving accurate early diagnosis and risk stratification.While traditional approaches rely heavily on subjective interpretations and variable expertise,machine learning(ML)has emerged as a transformative tool in healthcare.We conducted a comprehensive review of published literature on ML applications in esophageal diseases,analyzing technical approaches,validation methods,and clinical outcomes.ML demonstrates superior performance:In gastroesophageal reflux disease,ML models achieve 80%-90%accuracy in potential of hydrogen-impedance analysis and endoscopic grading;for Barrett’s esophagus,ML-based approaches show 88%-95% accuracy in invasive diagnostics and 77%-85% accuracy in non-invasive screening.In esophageal cancer,ML improves early detection and survival prediction by 6%-10% compared to traditional methods.Novel applications in achalasia and esophageal varices demonstrate promising results in automated diagnosis and risk stratification,with accuracy rates exceeding 85%.While challenges persist in data standardization,model interpretability,and clinical integration,emerging solutions in federated learning and explainable artificial intelligence offer promising pathways forward.The continued evolution of these technologies,coupled with rigorous validation and thoughtful implementation,may fundamentally transform our approach to esophageal disease management in the era of precision medicine.展开更多
The evacuation of people under threat is an effective disaster prevention and mitigation measure in response to flash floods and geological hazards,and it is also an essential element of pre-disaster planning.However,...The evacuation of people under threat is an effective disaster prevention and mitigation measure in response to flash floods and geological hazards,and it is also an essential element of pre-disaster planning.However,the effect of the interactions between perception factors on residents'willingness to evacuate is an urgent problem to be solved.Therefore,this paper introduces risk,stakeholder,and protective action perceptions from the protective action decision model as the main explanatory variables.These three core perceptions are subdivided into affective risk perception,cognitive risk perception,government perception,other-stakeholder perception,resourcerelated attributes,and hazard-related attributes.A questionnaire survey was conducted from June to July 2023 among residents of mountainous communities in nine villages in three towns in Sichuan Province,China.359 cross-sectional data were analyzed using structural equation modeling to explore the effects of six perception factors on evacuation intentions.The results of the study showed that:(1)affective risk perception,government perception,other-stakeholder perception,and hazard-related attributes all directly and positively influence residents'intentions to evacuate;(2)cognitive risk perception is mediated by stakeholder and protective action perceptions,which indirectly and positively affect residents'intentions to evacuate.Based on the hypothesized paths,strategies to improve residents'willingness to evacuate are discussed from the perspective of three core perceptions:strengthening disaster risk education,improving residents'cohesion,and building government credibility.The results of this study can provide theoretical support and practical suggestions for emergency management departments to formulate emergency evacuation strategies,which can aid decision-makers in better understanding residents'intentions to evacuate,optimizing evacuation information dissemination pathways,and strengthening disaster risk management capabilities.展开更多
The dramatic rise in the number of people living in cities has made many environmental and social problems worse.The search for a productive method for disposing of solid waste is the most notable of these problems.Ma...The dramatic rise in the number of people living in cities has made many environmental and social problems worse.The search for a productive method for disposing of solid waste is the most notable of these problems.Many scholars have referred to it as a fuzzy multi-attribute or multi-criteria decision-making problem using various fuzzy set-like approaches because of the inclusion of criteria and anticipated ambiguity.The goal of the current study is to use an innovative methodology to address the expected uncertainties in the problem of solid waste site selection.The characteristics(or sub-attributes)that decision-makers select and the degree of approximation they accept for various options can both be indicators of these uncertainties.To tackle these problems,a novel mathematical structure known as the fuzzy parameterized possibility single valued neutrosophic hypersoft expert set(ρˆ-set),which is initially described,is integrated with a modified version of Sanchez’s method.Following this,an intelligent algorithm is suggested.The steps of the suggested algorithm are explained with an example that explains itself.The compatibility of solid waste management sites and systems is discussed,and rankings are established along with detailed justifications for their viability.This study’s strengths lie in its application of fuzzy parameterization and possibility grading to effectively handle the uncertainties embodied in the parameters’nature and alternative approximations,respectively.It uses specific mathematical formulations to compute the fuzzy parameterized degrees and possibility grades that are missing from the prior literature.It is simpler for the decisionmakers to look at each option separately because the decision is uncertain.Comparing the computed results,it is discovered that they are consistent and dependable because of their preferred properties.展开更多
Developmental and reproductive toxicity(DART)endpoint entails a toxicological assessment of all developmental stages and reproductive cycles of an organism.In silico tools to predict DART will provide a method to asse...Developmental and reproductive toxicity(DART)endpoint entails a toxicological assessment of all developmental stages and reproductive cycles of an organism.In silico tools to predict DART will provide a method to assess this complex toxicity endpoint and will be valuable for screening emerging pollutants as well as for m anaging new chemicals in China.Currently,there are few published DART prediction models in China,but many related research and development projects are in progress.In 2013,WU et al.published an expert rule-based DART decision tree(DT).This DT relies on known chemical structures linked to DART to forecast DART potential of a given chemical.Within this procedure,an accurate DART data interpretation is the foundation of building and expanding the DT.This paper excerpted case studies demonstrating DART data curation and interpretation of four chemicals(including 8-hydroxyquinoline,3,5,6-trichloro-2-pyridinol,thiacloprid,and imidacloprid)to expand the existing DART DT.Chemicals were first selected from the database of Solid Waste and Chemicals Management Center,Ministry of Ecology and Environment(MEESCC)in China.The structures of these 4 chemicals were analyzed and preliminarily grouped by chemists based on core structural features,functional groups,receptor binding property,metabolism,and possible mode of actions.Then,the DART conclusion was derived by collecting chemical information,searching,integrating,and interpreting DART data by the toxicologists.Finally,these chemicals were classified into either an existing category or a new category via integrating their chemical features,DART conclusions,and biological properties.The results showed that 8-hydroxyquinoline impacted estrous cyclicity,s exual organ weights,and embryonal development,and 3,5,6-trichloro-2-pyridinol caused central nervous system(CNS)malformations,which were added to an existing subcategory 8e(aromatic compounds with multi-halogen and nitro groups)of the DT.Thiacloprid caused dystocia and fetal skeletal malformation,and imidacloprid disrupted the endocrine system and male fertility.They both contain 2-chloro-5-methylpyridine substituted imidazolidine c yclic ring,which were expected to create a new category of neonicotinoids.The current work delineates a t ransparent process of curating toxicological data for the purpose of DART data interpretation.In the presence of sufficient related structures and DART data,the DT can be expanded by iteratively adding chemicals within the a pplicable domain of each category or subcategory.This DT can potentially serve as a tool for screening emerging pollutants and assessing new chemicals in China.展开更多
A Receiver Operating Characteristic(ROC)analysis of a power is important and useful in clinical trials.A Classical Conditional Power(CCP)is a probability of a classical rejection region given values of true treatment ...A Receiver Operating Characteristic(ROC)analysis of a power is important and useful in clinical trials.A Classical Conditional Power(CCP)is a probability of a classical rejection region given values of true treatment effect and interim result.For hypotheses and reversed hypotheses under normal models,we obtain analytical expressions of the ROC curves of the CCP,find optimal ROC curves of the CCP,investigate the superiority of the ROC curves of the CCP,calculate critical values of the False Positive Rate(FPR),True Positive Rate(TPR),and cutoff of the optimal CCP,and give go/no go decisions at the interim of the optimal CCP.In addition,extensive numerical experiments are carried out to exemplify our theoretical results.Finally,a real data example is performed to illustrate the go/no go decisions of the optimal CCP.展开更多
People have been engaged in sports activities both individually and collectively for years.Sports consumption,which refers to the process that covers many issues related to sports in the form of playing,watching,liste...People have been engaged in sports activities both individually and collectively for years.Sports consumption,which refers to the process that covers many issues related to sports in the form of playing,watching,listening or reading,is a form of human behavior.The satisfaction of the four marketing components of product,price,distribution and promotion by using the leisure time of the sports consumer effectively and ensuring its continuity in the future process can be ensured by effective utilization of facilities and quality recreation activities.Consumer behaviors,which have a very complex structure,are seen in the form of choosing,buying,using and obtaining.With this study,it is aimed to determine the mediating role of consumer decision-making styles in determining the effect of marketing components in the consumption of sports activities on the satisfaction of sports consumers.In this direction,data were collected in the province of Istanbul,which was determined as the sample.Data were obtained with a questionnaire form created on Google Form.These data were analyzed in line with the model and hypotheses created with these data and it was determined that the marketing components of sports consumption have an impact on the sports consumer and it was concluded that consumer decision-making styles have a positive mediating effect in this regard.展开更多
Objective:To explore factors influencing decision regret among colorectal cancer patients undergoing intestinal ostomy.Methods:A questionnaire survey was conducted among 102 colorectal cancer patients who underwent in...Objective:To explore factors influencing decision regret among colorectal cancer patients undergoing intestinal ostomy.Methods:A questionnaire survey was conducted among 102 colorectal cancer patients who underwent intestinal ostomy surgery and visited the ostomy clinic at a tertiary hospital in Baoding from July to September 2025.The Chinese version of the Ostomy Adaptation Inventory(OAI-20),Decision Regret Scale(DRS),Decision Conflict Scale(DCS),and Functional Assessment of Cancer Therapy-Colorectal(FACT-C)were used to measure patients’adaptation to stoma,decision regret,decision conflict,and quality of life.The Shared Decision-Making Questionnaire(SDM-Q-9)assessed patient involvement in ostomy surgery decisions,while the SSUK-8 evaluated social support.Additional items explored perceptions related to decision-making,participation,and outcomes.Results:Among 134 eligible patients attending the clinic,120 participated in the questionnaire,with 102 completing all items.Stoma patients reported an average decision regret score of 60.83(SD 28.43),an average coping ability score of 54.26(SD 26.69),an average decision conflict score of 62.55(SD 25.95),and a quality of life score of 56.93(SD 27.46).In the multiple regression analysis,decision regret was associated with decision conflict,poor patient coping ability,low quality of life,and low social support.Conclusion:Decision regret is prevalent among Chinese CRC patients following ostomy surgery.Compared with similar studies in other regions,Chinese CRC patients exhibit a higher rate of regret.This may be related to lower patient involvement in decision-making,generally poorer quality of life,and heavier economic burdens.展开更多
When you go somewhere,do you like to be the driver or a passenger?When you are the driver,you are in control.You can go fast or slow.You can pick the route.When and where do you stop?You decide.You enjoy the feeling o...When you go somewhere,do you like to be the driver or a passenger?When you are the driver,you are in control.You can go fast or slow.You can pick the route.When and where do you stop?You decide.You enjoy the feeling of driving.Ifs fun!展开更多
1.Introduction Phase Ⅱ trials are typically designed to identify promising treatment therapies that warrant further investigation in subsequent phase Ⅲ con-firmatory trials,playing a vital role in evidence generatio...1.Introduction Phase Ⅱ trials are typically designed to identify promising treatment therapies that warrant further investigation in subsequent phase Ⅲ con-firmatory trials,playing a vital role in evidence generation of drug de-velopment.The basic design features of phase II trials include interim go/no-go decisions to prevent exposing too many patients to poten-tially ineffective treatments.Appropriate go/no-go decisions and effi-cient trial designs can shorten the research duration and increase trial success rates.展开更多
一、阅读理解主题:人与自我——生活与学习建议用时:7分钟The Wilsons decided to go overseas for vacation,They had a family meeting to plan the vacation."First,"Mr Wilson said,"we should decide where we are ...一、阅读理解主题:人与自我——生活与学习建议用时:7分钟The Wilsons decided to go overseas for vacation,They had a family meeting to plan the vacation."First,"Mr Wilson said,"we should decide where we are going.""I don't agree,"Mrs Wilson said."I think we should decide when we are going first,We don't want to go to places when they are cold."展开更多
This study focuses on the construction and application of intelligent financial decision-making models driven by generative artificial intelligence(AI).It analyzes the mechanisms by which generative AI empowers financ...This study focuses on the construction and application of intelligent financial decision-making models driven by generative artificial intelligence(AI).It analyzes the mechanisms by which generative AI empowers financial decision-making within a dual framework of dynamic knowledge evolution and risk control.The research reveals that generative AI,with its superior data processing,pattern recognition,and autonomous learning capabilities,can transcend the limitations of traditional decision-making models,facilitating a significant shift from causal inference to probabilistic creation in decision-making paradigms.By systematically constructing an intelligent financial decision-making model that includes data governance,core engine,and decision output layers,the study clarifies the functional roles and collaborative mechanisms of each layer.Additionally,it addresses key challenges in technology application,institutional adaptation,and organizational transformation by proposing systematic strategies for technical risk management,institutional innovation,and organizational capability enhancement,aiming to provide robust theoretical support and practical guidance for the intelligent transformation of corporate financial decision-making.展开更多
文摘Delayed wound healing following radical gastrectomy remains an important yet underappreciated complication that prolongs hospitalization,increases costs,and undermines patient recovery.In An et al’s recent study,the authors present a machine learning-based risk prediction approach using routinely available clinical and laboratory parameters.Among the evaluated algorithms,a decision tree model demonstrated excellent discrimination,achieving an area under the curve of 0.951 in the validation set and notably identifying all true cases of delayed wound healing at the Youden index threshold.The inclusion of variables such as drainage duration,preoperative white blood cell and neutrophil counts,alongside age and sex,highlights the pragmatic appeal of the model for early postoperative monitoring.Nevertheless,several aspects warrant critical reflection,including the reliance on a postoperative variable(drainage duration),internal validation only,and certain reporting inconsistencies.This letter underscores both the promise and the limitations of adopting interpretable machine learning models in perioperative care.We advocate for transparent reporting,external validation,and careful consideration of clinically actionable timepoints before integration into practice.Ultimately,this work represents a valuable step toward precision risk stratification in gastric cancer surgery,and sets the stage for multicenter,prospective evaluations.
基金the Strategic Research Plan of the Centre for Marine Technology and Ocean Engineering(CENTEC),which is financed by the Portuguese Foundation for Science and Technology(Fundação para a Ciência e a Tecnologia FCT)under contract UIDB/UIDP/00134/2020.
文摘This study examines the methods to plan the development of offshore oilfields over the years,which are used to support the decision-making on the development of offshore oilfields.About 100 papers are analysed and categorised into different groups of main early-stage decisions.The present study stands in contrast to the contributions of the operations research and system engineering review articles,on the one hand,and the petroleum engineering review articles,on the other.This is because it does not focus on one methodological approach,nor does it limit the literature analysis by offshore oilfield characteristics.Consequently,the present analysis may offer valuable insights,for instance,by identifying environmental planning decisions as a recent yet highly significant concern that is currently being imposed on decision-making process.Thus,it is evident that the incorporation of safety criteria within the technical-economic decision-making process for the design of production systems would be a crucial requirement at development phase.
文摘Across four studies,we explore the impact of solitude on consumers’reliance on feelings versus reasons in decision making,along with the underlying mechanism and boundary conditions.The results indicate that solitude individuals(vs.non-solitude)would prefer feeling-based strategy in decision-making,resulting in a higher intention of choosing the affectively superior option over the cognitively superior option(Study 1).Self-focus plays the underlying mechanism in the solitude effect(Study 2).Moreover,we also examine two boundary conditions:motivation(Study 3)and temporal orientation(Study 4),which indicates that involuntary motivation and future orientation can mitigate the solitude effect on affective processing.These findings provide insights into consumers’judgments of product attributes and selection of decision-making strategies according to their situations.
基金the National Council for Scientific and Technological Development of Brazil(CNPQ)the Coordination for the Improvement of Higher Education Personnel-Brazil(CAPES)(Grant PROAP 88887.842889/2023-00-PUC/MG,Grant PDPG 88887.708960/2022-00-PUC/MG-INFORMATICA and Finance Code 001)Minas Gerais State Research Support Foundation(FAPEMIG)under Grant No.:APQ-01929-22,and the Pontifical Catholic University of Minas Gerais,Brazil.
文摘Higher education institutions are becoming increasingly concerned with the retention of their students.This work is motivated by the interest in predicting and reducing student dropout,and consequently in reducing the financial losses of said institutions.Based on the characterization of the dropout problem and the application of a knowledge discovery process,an ensemble model is proposed to improve dropout prediction.The ensemble model combines the results of three models:logistic regression,neural networks,and decision tree.As a result,the model can correctly classify 89%of the students as enrolled or dropped and accurately identify 98.1%of dropouts.When compared with the Random Forest ensemble method,the proposed model demonstrates desirable characteristics to assist management in proposing actions to retain students.
基金funded by the National Natural Science Foundation of China(NSFC No.52322610)Hong Kong Research Grants Council Theme-based Research Scheme(T22-505/19-N).
文摘Effective wildland fire management requires real-time access to comprehensive and distilled information from different data sources.The Digital Twin technology becomes a promising tool in optimizing the processes of wildfire pre-vention,monitoring,disaster response,and post-fire recovery.This review examines the potential utility of Digital Twin in wildfire management and aims to inspire further exploration and experimentation by researchers and practitioners in the fields of environment,forestry,fire ecology,and firefighting services.By creating virtual replicas of wildfire in the physical world,a Digital Twin platform facilitates data integration from multiple sources,such as remote sensing,weather forecast-ing,and ground-based sensors,providing a holistic view of emergency response and decision-making.Furthermore,Digital Twin can support simulation-based training and scenario testing for prescribed fire planning and firefighting to improve preparedness and response to evacuation and rescue.Successful applications of Digital Twin in wildfire management require horizontal collaboration among researchers,practitioners,and stakeholders,as well as enhanced resource sharing and data exchange.This review seeks a deeper understanding of future wildland fire management from a technological perspective and inspiration of future research and implementation.Further research should focus on refining and validating Digital Twin models and the integration into existing fire management operations,and then demonstrating them in real wildland fires.
基金supported by the National Key Research and Development Program (No.2023YFC3502604)the National Natural Science Foundation of China (Nos.U23B2062, 82274352,82174533, 82374302, 82204941)+3 种基金the Noncommunicable Chronic Diseases-National Science and Technology Major Project (No.2023ZD0505700)the Beijing-Tianjin-Hebei Basic Research Cooperation Project (No.22JCZXJC00070)the State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture (No.SKL2024Z0102)Key R&D project of Ningxia Autonomous Region (No.2022BEG02036).
文摘Traditional Chinese medicine(TCM)represents a paradigmatic approach to personalized medicine,developed through the systematic accumulation and refinement of clinical empirical data over more than 2000 years,and now encompasses large-scale electronic medical records(EMR)and experimental molecular data.Artificial intelligence(AI)has demonstrated its utility in medicine through the development of various expert systems(e.g.,MYCIN)since the 1970s.With the emergence of deep learning and large language models(LLMs),AI’s potential in medicine shows considerable promise.Consequently,the integration of AI and TCM from both clinical and scientific perspectives presents a fundamental and promising research direction.This survey provides an insightful overview of TCM AI research,summarizing related research tasks from three perspectives:systems-level biological mechanism elucidation,real-world clinical evidence inference,and personalized clinical decision support.The review highlights representative AI methodologies alongside their applications in both TCM scientific inquiry and clinical practice.To critically assess the current state of the field,this work identifies major challenges and opportunities that constrain the development of robust research capabilities—particularly in the mechanistic understanding of TCM syndromes and herbal formulations,novel drug discovery,and the delivery of high-quality,patient-centered clinical care.The findings underscore that future advancements in AI-driven TCM research will rely on the development of high-quality,large-scale data repositories;the construction of comprehensive and domain-specific knowledge graphs(KGs);deeper insights into the biological mechanisms underpinning clinical efficacy;rigorous causal inference frameworks;and intelligent,personalized decision support systems.
基金Supported by the Central Funds Guiding the Local Science and Technology Development,No.202207AB110017Key Research and Development Program of Yunnan,No.202302AD080004+1 种基金Yunnan Academician and Expert Workstation,No.202205AF150023the Scientific and Technological Innovation Team in Kunming Medical University,No.CXTD202215.
文摘The complex pathophysiology and diverse manifestations of esophageal disorders pose challenges in clinical practice,particularly in achieving accurate early diagnosis and risk stratification.While traditional approaches rely heavily on subjective interpretations and variable expertise,machine learning(ML)has emerged as a transformative tool in healthcare.We conducted a comprehensive review of published literature on ML applications in esophageal diseases,analyzing technical approaches,validation methods,and clinical outcomes.ML demonstrates superior performance:In gastroesophageal reflux disease,ML models achieve 80%-90%accuracy in potential of hydrogen-impedance analysis and endoscopic grading;for Barrett’s esophagus,ML-based approaches show 88%-95% accuracy in invasive diagnostics and 77%-85% accuracy in non-invasive screening.In esophageal cancer,ML improves early detection and survival prediction by 6%-10% compared to traditional methods.Novel applications in achalasia and esophageal varices demonstrate promising results in automated diagnosis and risk stratification,with accuracy rates exceeding 85%.While challenges persist in data standardization,model interpretability,and clinical integration,emerging solutions in federated learning and explainable artificial intelligence offer promising pathways forward.The continued evolution of these technologies,coupled with rigorous validation and thoughtful implementation,may fundamentally transform our approach to esophageal disease management in the era of precision medicine.
基金supported by the National Natural Science Foundation of China(U20A20111)the National key R&D Program(2022YFC3080100)。
文摘The evacuation of people under threat is an effective disaster prevention and mitigation measure in response to flash floods and geological hazards,and it is also an essential element of pre-disaster planning.However,the effect of the interactions between perception factors on residents'willingness to evacuate is an urgent problem to be solved.Therefore,this paper introduces risk,stakeholder,and protective action perceptions from the protective action decision model as the main explanatory variables.These three core perceptions are subdivided into affective risk perception,cognitive risk perception,government perception,other-stakeholder perception,resourcerelated attributes,and hazard-related attributes.A questionnaire survey was conducted from June to July 2023 among residents of mountainous communities in nine villages in three towns in Sichuan Province,China.359 cross-sectional data were analyzed using structural equation modeling to explore the effects of six perception factors on evacuation intentions.The results of the study showed that:(1)affective risk perception,government perception,other-stakeholder perception,and hazard-related attributes all directly and positively influence residents'intentions to evacuate;(2)cognitive risk perception is mediated by stakeholder and protective action perceptions,which indirectly and positively affect residents'intentions to evacuate.Based on the hypothesized paths,strategies to improve residents'willingness to evacuate are discussed from the perspective of three core perceptions:strengthening disaster risk education,improving residents'cohesion,and building government credibility.The results of this study can provide theoretical support and practical suggestions for emergency management departments to formulate emergency evacuation strategies,which can aid decision-makers in better understanding residents'intentions to evacuate,optimizing evacuation information dissemination pathways,and strengthening disaster risk management capabilities.
文摘The dramatic rise in the number of people living in cities has made many environmental and social problems worse.The search for a productive method for disposing of solid waste is the most notable of these problems.Many scholars have referred to it as a fuzzy multi-attribute or multi-criteria decision-making problem using various fuzzy set-like approaches because of the inclusion of criteria and anticipated ambiguity.The goal of the current study is to use an innovative methodology to address the expected uncertainties in the problem of solid waste site selection.The characteristics(or sub-attributes)that decision-makers select and the degree of approximation they accept for various options can both be indicators of these uncertainties.To tackle these problems,a novel mathematical structure known as the fuzzy parameterized possibility single valued neutrosophic hypersoft expert set(ρˆ-set),which is initially described,is integrated with a modified version of Sanchez’s method.Following this,an intelligent algorithm is suggested.The steps of the suggested algorithm are explained with an example that explains itself.The compatibility of solid waste management sites and systems is discussed,and rankings are established along with detailed justifications for their viability.This study’s strengths lie in its application of fuzzy parameterization and possibility grading to effectively handle the uncertainties embodied in the parameters’nature and alternative approximations,respectively.It uses specific mathematical formulations to compute the fuzzy parameterized degrees and possibility grades that are missing from the prior literature.It is simpler for the decisionmakers to look at each option separately because the decision is uncertain.Comparing the computed results,it is discovered that they are consistent and dependable because of their preferred properties.
文摘Developmental and reproductive toxicity(DART)endpoint entails a toxicological assessment of all developmental stages and reproductive cycles of an organism.In silico tools to predict DART will provide a method to assess this complex toxicity endpoint and will be valuable for screening emerging pollutants as well as for m anaging new chemicals in China.Currently,there are few published DART prediction models in China,but many related research and development projects are in progress.In 2013,WU et al.published an expert rule-based DART decision tree(DT).This DT relies on known chemical structures linked to DART to forecast DART potential of a given chemical.Within this procedure,an accurate DART data interpretation is the foundation of building and expanding the DT.This paper excerpted case studies demonstrating DART data curation and interpretation of four chemicals(including 8-hydroxyquinoline,3,5,6-trichloro-2-pyridinol,thiacloprid,and imidacloprid)to expand the existing DART DT.Chemicals were first selected from the database of Solid Waste and Chemicals Management Center,Ministry of Ecology and Environment(MEESCC)in China.The structures of these 4 chemicals were analyzed and preliminarily grouped by chemists based on core structural features,functional groups,receptor binding property,metabolism,and possible mode of actions.Then,the DART conclusion was derived by collecting chemical information,searching,integrating,and interpreting DART data by the toxicologists.Finally,these chemicals were classified into either an existing category or a new category via integrating their chemical features,DART conclusions,and biological properties.The results showed that 8-hydroxyquinoline impacted estrous cyclicity,s exual organ weights,and embryonal development,and 3,5,6-trichloro-2-pyridinol caused central nervous system(CNS)malformations,which were added to an existing subcategory 8e(aromatic compounds with multi-halogen and nitro groups)of the DT.Thiacloprid caused dystocia and fetal skeletal malformation,and imidacloprid disrupted the endocrine system and male fertility.They both contain 2-chloro-5-methylpyridine substituted imidazolidine c yclic ring,which were expected to create a new category of neonicotinoids.The current work delineates a t ransparent process of curating toxicological data for the purpose of DART data interpretation.In the presence of sufficient related structures and DART data,the DT can be expanded by iteratively adding chemicals within the a pplicable domain of each category or subcategory.This DT can potentially serve as a tool for screening emerging pollutants and assessing new chemicals in China.
基金supported by the National Social Science Fund of China(Grand No.21XTJ001).
文摘A Receiver Operating Characteristic(ROC)analysis of a power is important and useful in clinical trials.A Classical Conditional Power(CCP)is a probability of a classical rejection region given values of true treatment effect and interim result.For hypotheses and reversed hypotheses under normal models,we obtain analytical expressions of the ROC curves of the CCP,find optimal ROC curves of the CCP,investigate the superiority of the ROC curves of the CCP,calculate critical values of the False Positive Rate(FPR),True Positive Rate(TPR),and cutoff of the optimal CCP,and give go/no go decisions at the interim of the optimal CCP.In addition,extensive numerical experiments are carried out to exemplify our theoretical results.Finally,a real data example is performed to illustrate the go/no go decisions of the optimal CCP.
文摘People have been engaged in sports activities both individually and collectively for years.Sports consumption,which refers to the process that covers many issues related to sports in the form of playing,watching,listening or reading,is a form of human behavior.The satisfaction of the four marketing components of product,price,distribution and promotion by using the leisure time of the sports consumer effectively and ensuring its continuity in the future process can be ensured by effective utilization of facilities and quality recreation activities.Consumer behaviors,which have a very complex structure,are seen in the form of choosing,buying,using and obtaining.With this study,it is aimed to determine the mediating role of consumer decision-making styles in determining the effect of marketing components in the consumption of sports activities on the satisfaction of sports consumers.In this direction,data were collected in the province of Istanbul,which was determined as the sample.Data were obtained with a questionnaire form created on Google Form.These data were analyzed in line with the model and hypotheses created with these data and it was determined that the marketing components of sports consumption have an impact on the sports consumer and it was concluded that consumer decision-making styles have a positive mediating effect in this regard.
文摘Objective:To explore factors influencing decision regret among colorectal cancer patients undergoing intestinal ostomy.Methods:A questionnaire survey was conducted among 102 colorectal cancer patients who underwent intestinal ostomy surgery and visited the ostomy clinic at a tertiary hospital in Baoding from July to September 2025.The Chinese version of the Ostomy Adaptation Inventory(OAI-20),Decision Regret Scale(DRS),Decision Conflict Scale(DCS),and Functional Assessment of Cancer Therapy-Colorectal(FACT-C)were used to measure patients’adaptation to stoma,decision regret,decision conflict,and quality of life.The Shared Decision-Making Questionnaire(SDM-Q-9)assessed patient involvement in ostomy surgery decisions,while the SSUK-8 evaluated social support.Additional items explored perceptions related to decision-making,participation,and outcomes.Results:Among 134 eligible patients attending the clinic,120 participated in the questionnaire,with 102 completing all items.Stoma patients reported an average decision regret score of 60.83(SD 28.43),an average coping ability score of 54.26(SD 26.69),an average decision conflict score of 62.55(SD 25.95),and a quality of life score of 56.93(SD 27.46).In the multiple regression analysis,decision regret was associated with decision conflict,poor patient coping ability,low quality of life,and low social support.Conclusion:Decision regret is prevalent among Chinese CRC patients following ostomy surgery.Compared with similar studies in other regions,Chinese CRC patients exhibit a higher rate of regret.This may be related to lower patient involvement in decision-making,generally poorer quality of life,and heavier economic burdens.
文摘When you go somewhere,do you like to be the driver or a passenger?When you are the driver,you are in control.You can go fast or slow.You can pick the route.When and where do you stop?You decide.You enjoy the feeling of driving.Ifs fun!
基金funded by Beijing Nova Program(grant number:20230484277)National Natural Science Foundation of China(grant number:82303955).
文摘1.Introduction Phase Ⅱ trials are typically designed to identify promising treatment therapies that warrant further investigation in subsequent phase Ⅲ con-firmatory trials,playing a vital role in evidence generation of drug de-velopment.The basic design features of phase II trials include interim go/no-go decisions to prevent exposing too many patients to poten-tially ineffective treatments.Appropriate go/no-go decisions and effi-cient trial designs can shorten the research duration and increase trial success rates.
文摘一、阅读理解主题:人与自我——生活与学习建议用时:7分钟The Wilsons decided to go overseas for vacation,They had a family meeting to plan the vacation."First,"Mr Wilson said,"we should decide where we are going.""I don't agree,"Mrs Wilson said."I think we should decide when we are going first,We don't want to go to places when they are cold."
文摘This study focuses on the construction and application of intelligent financial decision-making models driven by generative artificial intelligence(AI).It analyzes the mechanisms by which generative AI empowers financial decision-making within a dual framework of dynamic knowledge evolution and risk control.The research reveals that generative AI,with its superior data processing,pattern recognition,and autonomous learning capabilities,can transcend the limitations of traditional decision-making models,facilitating a significant shift from causal inference to probabilistic creation in decision-making paradigms.By systematically constructing an intelligent financial decision-making model that includes data governance,core engine,and decision output layers,the study clarifies the functional roles and collaborative mechanisms of each layer.Additionally,it addresses key challenges in technology application,institutional adaptation,and organizational transformation by proposing systematic strategies for technical risk management,institutional innovation,and organizational capability enhancement,aiming to provide robust theoretical support and practical guidance for the intelligent transformation of corporate financial decision-making.
