Additive manufacturing(AM),particularly fused deposition modeling(FDM),has emerged as a transformative technology in modern manufacturing processes.The dimensional accuracy of FDM-printed parts is crucial for ensuring...Additive manufacturing(AM),particularly fused deposition modeling(FDM),has emerged as a transformative technology in modern manufacturing processes.The dimensional accuracy of FDM-printed parts is crucial for ensuring their functional integrity and performance.To achieve sustainable manufacturing in FDM,it is necessary to optimize the print quality and time efficiency concurrently.However,owing to the complex interactions of printing parameters,achieving a balanced optimization of both remains challenging.This study examines four key factors affecting dimensional accuracy and print time:printing speed,layer thickness,nozzle temperature,and bed temperature.Fifty parameter sets were generated using enhanced Latin hypercube sampling.A whale optimization algorithm(WOA)-enhanced support vector regression(SVR)model was developed to predict dimen-sional errors and print time effectively,with non-dominated sorting genetic algorithm Ⅲ(NSGA-Ⅲ)utilized for multi-objective optimization.The technique for Order Preference by Similarity to Ideal Solution(TOPSIS)was applied to select a balanced solution from the Pareto front.In experimental validation,the parts printed using the optimized parameters exhibited excellent dimensional accuracy and printing efficiency.This study comprehensively considered optimizing the printing time and size to meet quality requirements while achieving higher printing efficiency and aiding in the realization of sustainable manufacturing in the field of AM.In addition,the printing of a specific prosthetic component was used as a case study,highlighting the high demands on both dimensional precision and printing efficiency.The optimized process parameters required significantly less printing time,while satisfying the dimensional accuracy requirements.This study provides valuable insights for achieving sustainable AM using FDM.展开更多
Blades are essential components of wind turbines.Reducing their fatigue loads during operation helps to extend their lifespan,but it is difficult to quickly and accurately calculate the fatigue loads of blades.To solv...Blades are essential components of wind turbines.Reducing their fatigue loads during operation helps to extend their lifespan,but it is difficult to quickly and accurately calculate the fatigue loads of blades.To solve this problem,this paper innovatively designs a data-driven blade load modeling method based on a deep learning framework through mechanism analysis,feature selection,and model construction.In the mechanism analysis part,the generation mechanism of blade loads and the load theoretical calculationmethod based on material damage theory are analyzed,and four measurable operating state parameters related to blade loads are screened;in the feature extraction part,15 characteristic indicators of each screened parameter are extracted in the time and frequency domain,and feature selection is completed through correlation analysis with blade loads to determine the input parameters of data-driven modeling;in the model construction part,a deep neural network based on feedforward and feedback propagation is designed to construct the nonlinear coupling relationship between the unit operating parameter characteristics and blade loads.The results show that the proposed method mines the wind turbine operating state characteristics highly correlated with the blade load,such as the standard deviation of wind speed.The model built using these characteristics has reasonable calculation and fitting capabilities for the blade load and shows a better fitting level for untrained out-of-sample data than the traditional scheme.Based on the mean absolute percentage error calculation,the modeling accuracy of the two blade loads can reach more than 90%and 80%,respectively,providing a good foundation for the subsequent optimization control to suppress the blade load.展开更多
The curse of dimensionality refers to the problem o increased sparsity and computational complexity when dealing with high-dimensional data.In recent years,the types and vari ables of industrial data have increased si...The curse of dimensionality refers to the problem o increased sparsity and computational complexity when dealing with high-dimensional data.In recent years,the types and vari ables of industrial data have increased significantly,making data driven models more challenging to develop.To address this prob lem,data augmentation technology has been introduced as an effective tool to solve the sparsity problem of high-dimensiona industrial data.This paper systematically explores and discusses the necessity,feasibility,and effectiveness of augmented indus trial data-driven modeling in the context of the curse of dimen sionality and virtual big data.Then,the process of data augmen tation modeling is analyzed,and the concept of data boosting augmentation is proposed.The data boosting augmentation involves designing the reliability weight and actual-virtual weigh functions,and developing a double weighted partial least squares model to optimize the three stages of data generation,data fusion and modeling.This approach significantly improves the inter pretability,effectiveness,and practicality of data augmentation in the industrial modeling.Finally,the proposed method is verified using practical examples of fault diagnosis systems and virtua measurement systems in the industry.The results demonstrate the effectiveness of the proposed approach in improving the accu racy and robustness of data-driven models,making them more suitable for real-world industrial applications.展开更多
The dynamical modeling of projectile systems with sufficient accuracy is of great difficulty due to high-dimensional space and various perturbations.With the rapid development of data science and scientific tools of m...The dynamical modeling of projectile systems with sufficient accuracy is of great difficulty due to high-dimensional space and various perturbations.With the rapid development of data science and scientific tools of measurement recently,there are numerous data-driven methods devoted to discovering governing laws from data.In this work,a data-driven method is employed to perform the modeling of the projectile based on the Kramers–Moyal formulas.More specifically,the four-dimensional projectile system is assumed as an It?stochastic differential equation.Then the least square method and sparse learning are applied to identify the drift coefficient and diffusion matrix from sample path data,which agree well with the real system.The effectiveness of the data-driven method demonstrates that it will become a powerful tool in extracting governing equations and predicting complex dynamical behaviors of the projectile.展开更多
With the continual deployment of power-electronics-interfaced renewable energy resources,increasing privacy concerns due to deregulation of electricity markets,and the diversification of demand-side activities,traditi...With the continual deployment of power-electronics-interfaced renewable energy resources,increasing privacy concerns due to deregulation of electricity markets,and the diversification of demand-side activities,traditional knowledge-based power system dynamic modeling methods are faced with unprecedented challenges.Data-driven modeling has been increasingly studied in recent years because of its lesser need for prior knowledge,higher capability of handling large-scale systems,and better adaptability to variations of system operating conditions.This paper discusses about the motivations and the generalized process of datadriven modeling,and provides a comprehensive overview of various state-of-the-art techniques and applications.It also comparatively presents the advantages and disadvantages of these methods and provides insight into outstanding challenges and possible research directions for the future.展开更多
Pressure differential deviations under static conditions and pressure convergence fluctuations under dynamic disturbances are widely reported problems with pressure differential control in pharmaceutical cleanrooms,ye...Pressure differential deviations under static conditions and pressure convergence fluctuations under dynamic disturbances are widely reported problems with pressure differential control in pharmaceutical cleanrooms,yet their underlying mechanisms and key reasons remain insufficiently explored.This study performed a field survey and model-based simulations to identify the major influencing parameters and quantify their influence on pressure differentials.Twelve pharmaceutical cleanrooms with varying environmental control parameters were included in the field survey,all of which were served by a variable air volume(VAV)ventilation system.Large deviations between actual and design pressure differentials were found,ranging from 10%to 42.5%,and a total of 24 uncertain parameters and their respective uncertainty ranges were identified.Based on the field survey,a data-driven pressure differential response model was developed using MATLAB/Simulink platform.The model fully took into account the system dynamics and facilitated real-time monitoring and control of the pressure differential.Sobol-based sensitivity analysis was then conducted to identify key influencing parameters of pressure differential deviations.The simulated results revealed that static pressure differential deviations were predominantly influenced by pressure sensing accuracy,exhaust airflow accuracy,and duct impedance,while dynamic disturbances were mainly driven by room envelope airtightness and supply airflow accuracy.The interactions between connected zones were pronounced.Rooms with higher branch duct impedance experienced smaller pressure differential deviations due to natural buffering characteristics,while the parameter uncertainties in these rooms significantly affected pressure differential in other rooms.These findings offer practical guidance for the design and operation of precise pressure differential control in pharmaceutical cleanrooms.展开更多
The hysteresis effect represents the difference in open circuit voltage(OCV)between the charge and discharge processes of batteries.An accurate estimation of open circuit voltage considering hysteresis is critical for...The hysteresis effect represents the difference in open circuit voltage(OCV)between the charge and discharge processes of batteries.An accurate estimation of open circuit voltage considering hysteresis is critical for precise modeling of LiFePO_(4)batteries.However,the intricate influence of state-of-charge(SOC),temperature,and battery aging have posed significant challenges for hysteresis modeling,which have not been comprehensively considered in existing studies.This paper proposes a data-driven approach with adversarial learning to model hysteresis under diverse conditions,addressing the intricate dependencies on SOC,temperature,and battery aging.First,a comprehensive experimental scheme is designed to collect hysteresis dataset under diverse SOC paths,temperatures and aging states.Second,the proposed data-driven model integrates a conditional generative adversarial network with long short-term memory networks to enhance the model’s accuracy and adaptability.The generator and discriminator are designed based on LSTM networks to capture the dependency of hysteresis on historical SOC and conditional information.Third,the conditional matrix,incorporating temperature,health state,and historical paths,is constructed to provide the scenario-specific information for the adversarial network,thereby enhancing the model’s adaptability.Experimental results demonstrate that the proposed model achieves a voltage error of less than 3.8 mV across various conditions,with accuracy improvements of 31.3–48.7%compared to three state-of-the-art models.展开更多
A data-driven modelling method for predicting the aero-derivative gas turbine start-up performance has been developed. The test data are used to correct the compressor and turbine sub-idle maps based on extrapolation,...A data-driven modelling method for predicting the aero-derivative gas turbine start-up performance has been developed. The test data are used to correct the compressor and turbine sub-idle maps based on extrapolation, enhancing the accuracy within the whole sub-idle range. The hydraulic starter and temperature lag models are concluded in this method. By the start-up component maps, hydraulic power and fuel supply, the start-up process can be simulated, and the performance characteristics of the gas turbine and components can be calculated. The model is verified by three sets of test data on different environmental operation condition. The error of start-up times, speeds, temperatures and pressures between the start-up simulation and test data are within 10%, showing a high modeling accuracy.展开更多
This study focuses on empirical modeling of the strength characteristics of urban soils contaminated with heavy metals using machine learning tools and their subsequent stabilization with ordinary Portland cement(OPC)...This study focuses on empirical modeling of the strength characteristics of urban soils contaminated with heavy metals using machine learning tools and their subsequent stabilization with ordinary Portland cement(OPC).For dataset collection,an extensive experimental program was designed to estimate the unconfined compressive strength(Qu)of heavy metal-contaminated soils collected from awide range of land use pattern,i.e.residential,industrial and roadside soils.Accordingly,a robust comparison of predictive performances of four data-driven models including extreme learning machines(ELMs),gene expression programming(GEP),random forests(RFs),and multiple linear regression(MLR)has been presented.For completeness,a comprehensive experimental database has been established and partitioned into 80%for training and 20%for testing the developed models.Inputs included varying levels of heavy metals like Cd,Cu,Cr,Pb and Zn,along with OPC.The results revealed that the GEP model outperformed its counterparts:explaining approximately 96%of the variability in both training(R2=0.964)and testing phases(R^(2)=0.961),and thus achieving the lowest RMSE and MAE values.ELM performed commendably but was slightly less accurate than GEP whereas MLR had the lowest performance metrics.GEP also provided the benefit of traceable mathematical equation,enhancing its applicability not just as a predictive but also as an explanatory tool.Despite its insights,the study is limited by its focus on a specific set of heavy metals and urban soil samples of a particular region,which may affect the generalizability of the findings to different contamination profiles or environmental conditions.The study recommends GEP for predicting Qu in heavy metal-contaminated soils,and suggests further research to adapt these models to different environmental conditions.展开更多
We propose a novel workflow for fast forward modeling of well logs in axially symmetric 2D models of the nearwellbore environment.The approach integrates the finite element method with deep residual neural networks to...We propose a novel workflow for fast forward modeling of well logs in axially symmetric 2D models of the nearwellbore environment.The approach integrates the finite element method with deep residual neural networks to achieve exceptional computational efficiency and accuracy.The workflow is demonstrated through the modeling of wireline electromagnetic propagation resistivity logs,where the measured responses exhibit a highly nonlinear relationship with formation properties.The motivation for this research is the need for advanced modeling al-gorithms that are fast enough for use in modern quantitative interpretation tools,where thousands of simulations may be required in iterative inversion processes.The proposed algorithm achieves a remarkable enhancement in performance,being up to 3000 times faster than the finite element method alone when utilizing a GPU.While still ensuring high accuracy,this makes it well-suited for practical applications when reliable payzone assessment is needed in complex environmental scenarios.Furthermore,the algorithm’s efficiency positions it as a promising tool for stochastic Bayesian inversion,facilitating reliable uncertainty quantification in subsurface property estimation.展开更多
Metaverse technologies are increasingly promoted as game-changers in transport planning,connectedautonomous mobility,and immersive traveler services.However,the field lacks a systematic review of what has been achieve...Metaverse technologies are increasingly promoted as game-changers in transport planning,connectedautonomous mobility,and immersive traveler services.However,the field lacks a systematic review of what has been achieved,where critical technical gaps remain,and where future deployments should be integrated.Using a transparent protocol-driven screening process,we reviewed 1589 records and retained 101 peer-reviewed journal and conference articles(2021–2025)that explicitly frame their contributions within a transport-oriented metaverse.Our reviewreveals a predominantly exploratory evidence base.Among the 101 studies reviewed,17(16.8%)apply fuzzymulticriteria decision-making,36(35.6%)feature digital-twin visualizations or simulation-based testbeds,9(8.9%)present hardware-in-the-loop or field pilots,and only 4(4.0%)report performance metrics such as latency,throughput,or safety under realistic network conditions.Over time,the literature evolves fromearly conceptual sketches(2021–2022)through simulation-centered frameworks(2023)to nascent engineering prototypes(2024–2025).To clarify persistent gaps,we synthesize findings into four foundational layers—geometry and rendering,distributed synchronization,cryptographic integrity,and human factors—enumerating essential algorithms(homogeneous 4×4 transforms,Lamport clocks,Raft consensus,Merkle proofs,sweep-and-prune collision culling,Q-learning,and real-time ergonomic feedback loops).A worked bus-fleet prototype illustrates how blockchain-based ticketing,reinforcement learning-optimized traffic signals,and extended reality dispatch can be integrated into a live digital twin.This prototype is supported by a threephase rollout strategy.Advancing the transport metaverse from blueprint to operation requires open data schemas,reproducible edge–cloud performance benchmarks,cross-disciplinary cyber-physical threat models,and city-scale sandboxes that apply their mathematical foundations in real-world settings.展开更多
Aerodynamic surrogate modeling mostly relies only on integrated loads data obtained from simulation or experiment,while neglecting and wasting the valuable distributed physical information on the surface.To make full ...Aerodynamic surrogate modeling mostly relies only on integrated loads data obtained from simulation or experiment,while neglecting and wasting the valuable distributed physical information on the surface.To make full use of both integrated and distributed loads,a modeling paradigm,called the heterogeneous data-driven aerodynamic modeling,is presented.The essential concept is to incorporate the physical information of distributed loads as additional constraints within the end-to-end aerodynamic modeling.Towards heterogenous data,a novel and easily applicable physical feature embedding modeling framework is designed.This framework extracts lowdimensional physical features from pressure distribution and then effectively enhances the modeling of the integrated loads via feature embedding.The proposed framework can be coupled with multiple feature extraction methods,and the well-performed generalization capabilities over different airfoils are verified through a transonic case.Compared with traditional direct modeling,the proposed framework can reduce testing errors by almost 50%.Given the same prediction accuracy,it can save more than half of the training samples.Furthermore,the visualization analysis has revealed a significant correlation between the discovered low-dimensional physical features and the heterogeneous aerodynamic loads,which shows the interpretability and credibility of the superior performance offered by the proposed deep learning framework.展开更多
Conventional automated machine learning(AutoML)technologies fall short in preprocessing low-quality raw data and adapting to varying indoor and outdoor environments,leading to accuracy reduction in forecasting short-t...Conventional automated machine learning(AutoML)technologies fall short in preprocessing low-quality raw data and adapting to varying indoor and outdoor environments,leading to accuracy reduction in forecasting short-term building energy loads.Moreover,their predictions are not transparent because of their black box nature.Hence,the building field currently lacks an AutoML framework capable of data quality enhancement,environment self-adaptation,and model interpretation.To address this research gap,an improved AutoML-based end-to-end data-driven modeling framework is proposed.Bayesian optimization is applied by this framework to find an optimal data preprocessing process for quality improvement of raw data.It bridges the gap where conventional AutoML technologies cannot automatically handle missing data and outliers.A sliding window-based model retraining strategy is utilized to achieve environment self-adaptation,contributing to the accuracy enhancement of AutoML technologies.Moreover,a local interpretable model-agnostic explanations-based approach is developed to interpret predictions made by the improved framework.It overcomes the poor interpretability of conventional AutoML technologies.The performance of the improved framework in forecasting one-hour ahead cooling loads is evaluated using two-year operational data from a real building.It is discovered that the accuracy of the improved framework increases by 4.24%–8.79%compared with four conventional frameworks for buildings with not only high-quality but also low-quality operational data.Furthermore,it is demonstrated that the developed model interpretation approach can effectively explain the predictions of the improved framework.The improved framework offers a novel perspective on creating accurate and reliable AutoML frameworks tailored to building energy load prediction tasks and other similar tasks.展开更多
We propose an integrated method of data-driven and mechanism models for well logging formation evaluation,explicitly focusing on predicting reservoir parameters,such as porosity and water saturation.Accurately interpr...We propose an integrated method of data-driven and mechanism models for well logging formation evaluation,explicitly focusing on predicting reservoir parameters,such as porosity and water saturation.Accurately interpreting these parameters is crucial for effectively exploring and developing oil and gas.However,with the increasing complexity of geological conditions in this industry,there is a growing demand for improved accuracy in reservoir parameter prediction,leading to higher costs associated with manual interpretation.The conventional logging interpretation methods rely on empirical relationships between logging data and reservoir parameters,which suffer from low interpretation efficiency,intense subjectivity,and suitability for ideal conditions.The application of artificial intelligence in the interpretation of logging data provides a new solution to the problems existing in traditional methods.It is expected to improve the accuracy and efficiency of the interpretation.If large and high-quality datasets exist,data-driven models can reveal relationships of arbitrary complexity.Nevertheless,constructing sufficiently large logging datasets with reliable labels remains challenging,making it difficult to apply data-driven models effectively in logging data interpretation.Furthermore,data-driven models often act as“black boxes”without explaining their predictions or ensuring compliance with primary physical constraints.This paper proposes a machine learning method with strong physical constraints by integrating mechanism and data-driven models.Prior knowledge of logging data interpretation is embedded into machine learning regarding network structure,loss function,and optimization algorithm.We employ the Physically Informed Auto-Encoder(PIAE)to predict porosity and water saturation,which can be trained without labeled reservoir parameters using self-supervised learning techniques.This approach effectively achieves automated interpretation and facilitates generalization across diverse datasets.展开更多
The distillation process is an important chemical process,and the application of data-driven modelling approach has the potential to reduce model complexity compared to mechanistic modelling,thus improving the efficie...The distillation process is an important chemical process,and the application of data-driven modelling approach has the potential to reduce model complexity compared to mechanistic modelling,thus improving the efficiency of process optimization or monitoring studies.However,the distillation process is highly nonlinear and has multiple uncertainty perturbation intervals,which brings challenges to accurate data-driven modelling of distillation processes.This paper proposes a systematic data-driven modelling framework to solve these problems.Firstly,data segment variance was introduced into the K-means algorithm to form K-means data interval(KMDI)clustering in order to cluster the data into perturbed and steady state intervals for steady-state data extraction.Secondly,maximal information coefficient(MIC)was employed to calculate the nonlinear correlation between variables for removing redundant features.Finally,extreme gradient boosting(XGBoost)was integrated as the basic learner into adaptive boosting(AdaBoost)with the error threshold(ET)set to improve weights update strategy to construct the new integrated learning algorithm,XGBoost-AdaBoost-ET.The superiority of the proposed framework is verified by applying this data-driven modelling framework to a real industrial process of propylene distillation.展开更多
The pH-sensitive hydrogels play a crucial role in applications such as soft robotics,drug delivery,and biomedical sensors,as they require precise control of swelling behaviors and stress distributions.Traditional expe...The pH-sensitive hydrogels play a crucial role in applications such as soft robotics,drug delivery,and biomedical sensors,as they require precise control of swelling behaviors and stress distributions.Traditional experimental methods struggle to capture stress distributions due to technical limitations,while numerical approaches are often computationally intensive.This study presents a hybrid framework combining analytical modeling and machine learning(ML)to overcome these challenges.An analytical model is used to simulate transient swelling behaviors and stress distributions,and is confirmed to be viable through the comparison of the obtained simulation results with the existing experimental swelling data.The predictions from this model are used to train neural networks,including a two-step augmented architecture.The initial neural network predicts hydration values,which are then fed into a second network to predict stress distributions,effectively capturing nonlinear interdependencies.This approach achieves mean absolute errors(MAEs)as low as 0.031,with average errors of 1.9%for the radial stress and 2.55%for the hoop stress.This framework significantly enhances the predictive accuracy and reduces the computational complexity,offering actionable insights for optimizing hydrogel-based systems.展开更多
Permanent magnet synchronous motor(PMSM)is widely used in alternating current servo systems as it provides high eficiency,high power density,and a wide speed regulation range.The servo system is placing higher demands...Permanent magnet synchronous motor(PMSM)is widely used in alternating current servo systems as it provides high eficiency,high power density,and a wide speed regulation range.The servo system is placing higher demands on its control performance.The model predictive control(MPC)algorithm is emerging as a potential high-performance motor control algorithm due to its capability of handling multiple-input and multipleoutput variables and imposed constraints.For the MPC used in the PMSM control process,there is a nonlinear disturbance caused by the change of electromagnetic parameters or load disturbance that may lead to a mismatch between the nominal model and the controlled object,which causes the prediction error and thus affects the dynamic stability of the control system.This paper proposes a data-driven MPC strategy in which the historical data in an appropriate range are utilized to eliminate the impact of parameter mismatch and further improve the control performance.The stability of the proposed algorithm is proved as the simulation demonstrates the feasibility.Compared with the classical MPC strategy,the superiority of the algorithm has also been verified.展开更多
As a key node of modern transportation network,the informationization management of road tunnels is crucial to ensure the operation safety and traffic efficiency.However,the existing tunnel vehicle modeling methods ge...As a key node of modern transportation network,the informationization management of road tunnels is crucial to ensure the operation safety and traffic efficiency.However,the existing tunnel vehicle modeling methods generally have problems such as insufficient 3D scene description capability and low dynamic update efficiency,which are difficult to meet the demand of real-time accurate management.For this reason,this paper proposes a vehicle twin modeling method for road tunnels.This approach starts from the actual management needs,and supports multi-level dynamic modeling from vehicle type,size to color by constructing a vehicle model library that can be flexibly invoked;at the same time,semantic constraint rules with geometric layout,behavioral attributes,and spatial relationships are designed to ensure that the virtual model matches with the real model with a high degree of similarity;ultimately,the prototype system is constructed and the case region is selected for the case study,and the dynamic vehicle status in the tunnel is realized by integrating real-time monitoring data with semantic constraints for precise virtual-real mapping.Finally,the prototype system is constructed and case experiments are conducted in selected case areas,which are combined with real-time monitoring data to realize dynamic updating and three-dimensional visualization of vehicle states in tunnels.The experiments show that the proposed method can run smoothly with an average rendering efficiency of 17.70 ms while guaranteeing the modeling accuracy(composite similarity of 0.867),which significantly improves the real-time and intuitive tunnel management.The research results provide reliable technical support for intelligent operation and emergency response of road tunnels,and offer new ideas for digital twin modeling of complex scenes.展开更多
Using a dynamic laser monitoring technique,the solubility of 3-nitro-1,2,4-triazole-5-one(NTO)was investigated in two different binary systems,namely hydroxylamine nitrate(HAN)-water and boric acid(HB)-water ranging f...Using a dynamic laser monitoring technique,the solubility of 3-nitro-1,2,4-triazole-5-one(NTO)was investigated in two different binary systems,namely hydroxylamine nitrate(HAN)-water and boric acid(HB)-water ranging from 278.15 K to 318.15 K.The solubility in each system was found to be positively correlated with temperature.Furthermore,solubility data were analyzed using four equations:the modified Apelblat equation,Van’t Hoff equation,λh equation and CNIBS/R-K equations,and they provided satisfactory results for both two systems.The average root-mean-square deviation(105RMSD)values for these models were less than 13.93.Calculations utilizing the Van’t Hoff equation and Gibbs equations facilitated the derivation of apparent thermodynamic properties of NTO dissolution in the two systems,including values for Gibbs free energy,enthalpy and entropy.The%ζ_(H)is larger than%ζ_(TS),and all the%ζ_(H)data are≥58.63%,indicating that the enthalpy make a greater contribution than entropy to theΔG_(soln)^(Θ).展开更多
BACKGROUND Emerging evidence implicates Candida albicans(C.albicans)in human oncogenesis.Notably,studies have supported its involvement in regulating outcomes in colorectal cancer(CRC).This study investigated the para...BACKGROUND Emerging evidence implicates Candida albicans(C.albicans)in human oncogenesis.Notably,studies have supported its involvement in regulating outcomes in colorectal cancer(CRC).This study investigated the paradoxical role of C.albicans in CRC,aiming to determine whether it promotes or suppresses tumor development,with a focus on the mechanistic basis linked to its metabolic profile.AIM To investigate the dual role of C.albicans in the development and progression of CRC through metabolite profiling and to establish a prognostic model that integrates the microbial and metabolic interactions in CRC,providing insights into potential therapeutic strategies and clinical outcomes.METHODSA prognostic model integrating C. albicans with CRC was developed, incorporating enrichment analysis, immuneinfiltration profiling, survival analysis, Mendelian randomization, single-cell sequencing, and spatial transcriptomics.The effects of the C. albicans metabolite mixture on CRC cells were subsequently validated in vitro. Theprimary metabolite composition was characterized using liquid chromatography-mass spectrometry.RESULTSA prognostic model based on five specific mRNA markers, EHD4, LIME1, GADD45B, TIMP1, and FDFT1, wasestablished. The C. albicans metabolite mixture significantly reduced CRC cell viability. Post-treatment analysisrevealed a significant decrease in gene expression in HT29 cells, while the expression levels of TIMP1, EHD4, andGADD45B were significantly elevated in HCT116 cells. Conversely, LIME1 expression and that of other CRC celllines showed reductions. In normal colonic epithelial cells (NCM460), GADD45B, TIMP1, and FDFT1 expressionlevels were significantly increased, while LIME1 and EHD4 levels were markedly reduced. Following metabolitetreatment, the invasive and migratory capabilities of NCM460, HT29, and HCT116 cells were reduced. Quantitativeanalysis of extracellular ATP post-treatment showed a significant elevation (P < 0.01). The C. albicans metabolitemixture had no effect on reactive oxygen species accumulation in CRC cells but led to a reduction in mitochondrialmembrane potential, increased intracellular lipid peroxidation, and induced apoptosis. Metabolomic profilingrevealed significant alterations, with 516 metabolites upregulated and 531 downregulated.CONCLUSIONThis study introduced a novel prognostic model for CRC risk assessment. The findings suggested that the C.albicans metabolite mixture exerted an inhibitory effect on CRC initiation.展开更多
基金supporteded by Natural Science Foundation of Shanghai(Grant No.22ZR1463900)State Key Laboratory of Mechanical System and Vibration(Grant No.MSV202318)the Fundamental Research Funds for the Central Universities(Grant No.22120220649).
文摘Additive manufacturing(AM),particularly fused deposition modeling(FDM),has emerged as a transformative technology in modern manufacturing processes.The dimensional accuracy of FDM-printed parts is crucial for ensuring their functional integrity and performance.To achieve sustainable manufacturing in FDM,it is necessary to optimize the print quality and time efficiency concurrently.However,owing to the complex interactions of printing parameters,achieving a balanced optimization of both remains challenging.This study examines four key factors affecting dimensional accuracy and print time:printing speed,layer thickness,nozzle temperature,and bed temperature.Fifty parameter sets were generated using enhanced Latin hypercube sampling.A whale optimization algorithm(WOA)-enhanced support vector regression(SVR)model was developed to predict dimen-sional errors and print time effectively,with non-dominated sorting genetic algorithm Ⅲ(NSGA-Ⅲ)utilized for multi-objective optimization.The technique for Order Preference by Similarity to Ideal Solution(TOPSIS)was applied to select a balanced solution from the Pareto front.In experimental validation,the parts printed using the optimized parameters exhibited excellent dimensional accuracy and printing efficiency.This study comprehensively considered optimizing the printing time and size to meet quality requirements while achieving higher printing efficiency and aiding in the realization of sustainable manufacturing in the field of AM.In addition,the printing of a specific prosthetic component was used as a case study,highlighting the high demands on both dimensional precision and printing efficiency.The optimized process parameters required significantly less printing time,while satisfying the dimensional accuracy requirements.This study provides valuable insights for achieving sustainable AM using FDM.
基金supported by Science and Technology Project funding from China Southern Power Grid Corporation No.GDKJXM20230245(031700KC23020003).
文摘Blades are essential components of wind turbines.Reducing their fatigue loads during operation helps to extend their lifespan,but it is difficult to quickly and accurately calculate the fatigue loads of blades.To solve this problem,this paper innovatively designs a data-driven blade load modeling method based on a deep learning framework through mechanism analysis,feature selection,and model construction.In the mechanism analysis part,the generation mechanism of blade loads and the load theoretical calculationmethod based on material damage theory are analyzed,and four measurable operating state parameters related to blade loads are screened;in the feature extraction part,15 characteristic indicators of each screened parameter are extracted in the time and frequency domain,and feature selection is completed through correlation analysis with blade loads to determine the input parameters of data-driven modeling;in the model construction part,a deep neural network based on feedforward and feedback propagation is designed to construct the nonlinear coupling relationship between the unit operating parameter characteristics and blade loads.The results show that the proposed method mines the wind turbine operating state characteristics highly correlated with the blade load,such as the standard deviation of wind speed.The model built using these characteristics has reasonable calculation and fitting capabilities for the blade load and shows a better fitting level for untrained out-of-sample data than the traditional scheme.Based on the mean absolute percentage error calculation,the modeling accuracy of the two blade loads can reach more than 90%and 80%,respectively,providing a good foundation for the subsequent optimization control to suppress the blade load.
基金supported in part by the National Natural Science Foundation of China(NSFC)(92167106,61833014)Key Research and Development Program of Zhejiang Province(2022C01206)。
文摘The curse of dimensionality refers to the problem o increased sparsity and computational complexity when dealing with high-dimensional data.In recent years,the types and vari ables of industrial data have increased significantly,making data driven models more challenging to develop.To address this prob lem,data augmentation technology has been introduced as an effective tool to solve the sparsity problem of high-dimensiona industrial data.This paper systematically explores and discusses the necessity,feasibility,and effectiveness of augmented indus trial data-driven modeling in the context of the curse of dimen sionality and virtual big data.Then,the process of data augmen tation modeling is analyzed,and the concept of data boosting augmentation is proposed.The data boosting augmentation involves designing the reliability weight and actual-virtual weigh functions,and developing a double weighted partial least squares model to optimize the three stages of data generation,data fusion and modeling.This approach significantly improves the inter pretability,effectiveness,and practicality of data augmentation in the industrial modeling.Finally,the proposed method is verified using practical examples of fault diagnosis systems and virtua measurement systems in the industry.The results demonstrate the effectiveness of the proposed approach in improving the accu racy and robustness of data-driven models,making them more suitable for real-world industrial applications.
基金the Six Talent Peaks Project in Jiangsu Province,China(Grant No.JXQC-002)。
文摘The dynamical modeling of projectile systems with sufficient accuracy is of great difficulty due to high-dimensional space and various perturbations.With the rapid development of data science and scientific tools of measurement recently,there are numerous data-driven methods devoted to discovering governing laws from data.In this work,a data-driven method is employed to perform the modeling of the projectile based on the Kramers–Moyal formulas.More specifically,the four-dimensional projectile system is assumed as an It?stochastic differential equation.Then the least square method and sparse learning are applied to identify the drift coefficient and diffusion matrix from sample path data,which agree well with the real system.The effectiveness of the data-driven method demonstrates that it will become a powerful tool in extracting governing equations and predicting complex dynamical behaviors of the projectile.
基金supported by the U.S.Department of Energy’s Office of Energy Efficiency and Renewable Energy(EERE)under the Solar Energy Technologies Office Award Number 38456.
文摘With the continual deployment of power-electronics-interfaced renewable energy resources,increasing privacy concerns due to deregulation of electricity markets,and the diversification of demand-side activities,traditional knowledge-based power system dynamic modeling methods are faced with unprecedented challenges.Data-driven modeling has been increasingly studied in recent years because of its lesser need for prior knowledge,higher capability of handling large-scale systems,and better adaptability to variations of system operating conditions.This paper discusses about the motivations and the generalized process of datadriven modeling,and provides a comprehensive overview of various state-of-the-art techniques and applications.It also comparatively presents the advantages and disadvantages of these methods and provides insight into outstanding challenges and possible research directions for the future.
基金supported by the Natural Science Foundation of Hunan Province of China(No.2024JJ9082)by the Fundamental Research Funds for the Central Universities(No.531118010378).
文摘Pressure differential deviations under static conditions and pressure convergence fluctuations under dynamic disturbances are widely reported problems with pressure differential control in pharmaceutical cleanrooms,yet their underlying mechanisms and key reasons remain insufficiently explored.This study performed a field survey and model-based simulations to identify the major influencing parameters and quantify their influence on pressure differentials.Twelve pharmaceutical cleanrooms with varying environmental control parameters were included in the field survey,all of which were served by a variable air volume(VAV)ventilation system.Large deviations between actual and design pressure differentials were found,ranging from 10%to 42.5%,and a total of 24 uncertain parameters and their respective uncertainty ranges were identified.Based on the field survey,a data-driven pressure differential response model was developed using MATLAB/Simulink platform.The model fully took into account the system dynamics and facilitated real-time monitoring and control of the pressure differential.Sobol-based sensitivity analysis was then conducted to identify key influencing parameters of pressure differential deviations.The simulated results revealed that static pressure differential deviations were predominantly influenced by pressure sensing accuracy,exhaust airflow accuracy,and duct impedance,while dynamic disturbances were mainly driven by room envelope airtightness and supply airflow accuracy.The interactions between connected zones were pronounced.Rooms with higher branch duct impedance experienced smaller pressure differential deviations due to natural buffering characteristics,while the parameter uncertainties in these rooms significantly affected pressure differential in other rooms.These findings offer practical guidance for the design and operation of precise pressure differential control in pharmaceutical cleanrooms.
基金supported by the Natural Science Foundation of China(No.52377221,62172448)the Natural Science Foundation of Hunan Province,China(No.2023JJ30698)+1 种基金Part of the work is supported by the research project“COBALT-P”(16BZF314C)funded by the German Federal Ministry for Economic Affairs and Climate Action(BMWK).Lisen Yan is supported by China Scholarship Council(Grant No.202206370146).
文摘The hysteresis effect represents the difference in open circuit voltage(OCV)between the charge and discharge processes of batteries.An accurate estimation of open circuit voltage considering hysteresis is critical for precise modeling of LiFePO_(4)batteries.However,the intricate influence of state-of-charge(SOC),temperature,and battery aging have posed significant challenges for hysteresis modeling,which have not been comprehensively considered in existing studies.This paper proposes a data-driven approach with adversarial learning to model hysteresis under diverse conditions,addressing the intricate dependencies on SOC,temperature,and battery aging.First,a comprehensive experimental scheme is designed to collect hysteresis dataset under diverse SOC paths,temperatures and aging states.Second,the proposed data-driven model integrates a conditional generative adversarial network with long short-term memory networks to enhance the model’s accuracy and adaptability.The generator and discriminator are designed based on LSTM networks to capture the dependency of hysteresis on historical SOC and conditional information.Third,the conditional matrix,incorporating temperature,health state,and historical paths,is constructed to provide the scenario-specific information for the adversarial network,thereby enhancing the model’s adaptability.Experimental results demonstrate that the proposed model achieves a voltage error of less than 3.8 mV across various conditions,with accuracy improvements of 31.3–48.7%compared to three state-of-the-art models.
基金the Excellence Research Group Program(ERGP,the former Basic Science Center Program)No.52488101the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA 29050000)for sponsoring the work in this paper.
文摘A data-driven modelling method for predicting the aero-derivative gas turbine start-up performance has been developed. The test data are used to correct the compressor and turbine sub-idle maps based on extrapolation, enhancing the accuracy within the whole sub-idle range. The hydraulic starter and temperature lag models are concluded in this method. By the start-up component maps, hydraulic power and fuel supply, the start-up process can be simulated, and the performance characteristics of the gas turbine and components can be calculated. The model is verified by three sets of test data on different environmental operation condition. The error of start-up times, speeds, temperatures and pressures between the start-up simulation and test data are within 10%, showing a high modeling accuracy.
基金funded by the Natural Science Foundation of China(Grant No.52090084)was partially supported by the Sand Hazards and Opportunities for Resilience,Energy,and Sustainability(SHORES)Center,funded by Tamkeen under the NYUAD Research Institute Award CG013.
文摘This study focuses on empirical modeling of the strength characteristics of urban soils contaminated with heavy metals using machine learning tools and their subsequent stabilization with ordinary Portland cement(OPC).For dataset collection,an extensive experimental program was designed to estimate the unconfined compressive strength(Qu)of heavy metal-contaminated soils collected from awide range of land use pattern,i.e.residential,industrial and roadside soils.Accordingly,a robust comparison of predictive performances of four data-driven models including extreme learning machines(ELMs),gene expression programming(GEP),random forests(RFs),and multiple linear regression(MLR)has been presented.For completeness,a comprehensive experimental database has been established and partitioned into 80%for training and 20%for testing the developed models.Inputs included varying levels of heavy metals like Cd,Cu,Cr,Pb and Zn,along with OPC.The results revealed that the GEP model outperformed its counterparts:explaining approximately 96%of the variability in both training(R2=0.964)and testing phases(R^(2)=0.961),and thus achieving the lowest RMSE and MAE values.ELM performed commendably but was slightly less accurate than GEP whereas MLR had the lowest performance metrics.GEP also provided the benefit of traceable mathematical equation,enhancing its applicability not just as a predictive but also as an explanatory tool.Despite its insights,the study is limited by its focus on a specific set of heavy metals and urban soil samples of a particular region,which may affect the generalizability of the findings to different contamination profiles or environmental conditions.The study recommends GEP for predicting Qu in heavy metal-contaminated soils,and suggests further research to adapt these models to different environmental conditions.
基金financially supported by the Russian federal research project No.FWZZ-2022-0026“Innovative aspects of electro-dynamics in problems of exploration and oilfield geophysics”.
文摘We propose a novel workflow for fast forward modeling of well logs in axially symmetric 2D models of the nearwellbore environment.The approach integrates the finite element method with deep residual neural networks to achieve exceptional computational efficiency and accuracy.The workflow is demonstrated through the modeling of wireline electromagnetic propagation resistivity logs,where the measured responses exhibit a highly nonlinear relationship with formation properties.The motivation for this research is the need for advanced modeling al-gorithms that are fast enough for use in modern quantitative interpretation tools,where thousands of simulations may be required in iterative inversion processes.The proposed algorithm achieves a remarkable enhancement in performance,being up to 3000 times faster than the finite element method alone when utilizing a GPU.While still ensuring high accuracy,this makes it well-suited for practical applications when reliable payzone assessment is needed in complex environmental scenarios.Furthermore,the algorithm’s efficiency positions it as a promising tool for stochastic Bayesian inversion,facilitating reliable uncertainty quantification in subsurface property estimation.
基金financial support from the Centro de Matematica da Universidade doMinho(CMAT/UM),through project UID/00013.
文摘Metaverse technologies are increasingly promoted as game-changers in transport planning,connectedautonomous mobility,and immersive traveler services.However,the field lacks a systematic review of what has been achieved,where critical technical gaps remain,and where future deployments should be integrated.Using a transparent protocol-driven screening process,we reviewed 1589 records and retained 101 peer-reviewed journal and conference articles(2021–2025)that explicitly frame their contributions within a transport-oriented metaverse.Our reviewreveals a predominantly exploratory evidence base.Among the 101 studies reviewed,17(16.8%)apply fuzzymulticriteria decision-making,36(35.6%)feature digital-twin visualizations or simulation-based testbeds,9(8.9%)present hardware-in-the-loop or field pilots,and only 4(4.0%)report performance metrics such as latency,throughput,or safety under realistic network conditions.Over time,the literature evolves fromearly conceptual sketches(2021–2022)through simulation-centered frameworks(2023)to nascent engineering prototypes(2024–2025).To clarify persistent gaps,we synthesize findings into four foundational layers—geometry and rendering,distributed synchronization,cryptographic integrity,and human factors—enumerating essential algorithms(homogeneous 4×4 transforms,Lamport clocks,Raft consensus,Merkle proofs,sweep-and-prune collision culling,Q-learning,and real-time ergonomic feedback loops).A worked bus-fleet prototype illustrates how blockchain-based ticketing,reinforcement learning-optimized traffic signals,and extended reality dispatch can be integrated into a live digital twin.This prototype is supported by a threephase rollout strategy.Advancing the transport metaverse from blueprint to operation requires open data schemas,reproducible edge–cloud performance benchmarks,cross-disciplinary cyber-physical threat models,and city-scale sandboxes that apply their mathematical foundations in real-world settings.
基金supported by the National Natural Science Foundation of China(Nos.92152301,12072282)。
文摘Aerodynamic surrogate modeling mostly relies only on integrated loads data obtained from simulation or experiment,while neglecting and wasting the valuable distributed physical information on the surface.To make full use of both integrated and distributed loads,a modeling paradigm,called the heterogeneous data-driven aerodynamic modeling,is presented.The essential concept is to incorporate the physical information of distributed loads as additional constraints within the end-to-end aerodynamic modeling.Towards heterogenous data,a novel and easily applicable physical feature embedding modeling framework is designed.This framework extracts lowdimensional physical features from pressure distribution and then effectively enhances the modeling of the integrated loads via feature embedding.The proposed framework can be coupled with multiple feature extraction methods,and the well-performed generalization capabilities over different airfoils are verified through a transonic case.Compared with traditional direct modeling,the proposed framework can reduce testing errors by almost 50%.Given the same prediction accuracy,it can save more than half of the training samples.Furthermore,the visualization analysis has revealed a significant correlation between the discovered low-dimensional physical features and the heterogeneous aerodynamic loads,which shows the interpretability and credibility of the superior performance offered by the proposed deep learning framework.
基金funded by the National Natural Science Foundation of China(No.52161135202)Hangzhou Key Scientific Research Plan Project(No.2023SZD0028).
文摘Conventional automated machine learning(AutoML)technologies fall short in preprocessing low-quality raw data and adapting to varying indoor and outdoor environments,leading to accuracy reduction in forecasting short-term building energy loads.Moreover,their predictions are not transparent because of their black box nature.Hence,the building field currently lacks an AutoML framework capable of data quality enhancement,environment self-adaptation,and model interpretation.To address this research gap,an improved AutoML-based end-to-end data-driven modeling framework is proposed.Bayesian optimization is applied by this framework to find an optimal data preprocessing process for quality improvement of raw data.It bridges the gap where conventional AutoML technologies cannot automatically handle missing data and outliers.A sliding window-based model retraining strategy is utilized to achieve environment self-adaptation,contributing to the accuracy enhancement of AutoML technologies.Moreover,a local interpretable model-agnostic explanations-based approach is developed to interpret predictions made by the improved framework.It overcomes the poor interpretability of conventional AutoML technologies.The performance of the improved framework in forecasting one-hour ahead cooling loads is evaluated using two-year operational data from a real building.It is discovered that the accuracy of the improved framework increases by 4.24%–8.79%compared with four conventional frameworks for buildings with not only high-quality but also low-quality operational data.Furthermore,it is demonstrated that the developed model interpretation approach can effectively explain the predictions of the improved framework.The improved framework offers a novel perspective on creating accurate and reliable AutoML frameworks tailored to building energy load prediction tasks and other similar tasks.
基金supported by National Key Research and Development Program (2019YFA0708301)National Natural Science Foundation of China (51974337)+2 种基金the Strategic Cooperation Projects of CNPC and CUPB (ZLZX2020-03)Science and Technology Innovation Fund of CNPC (2021DQ02-0403)Open Fund of Petroleum Exploration and Development Research Institute of CNPC (2022-KFKT-09)
文摘We propose an integrated method of data-driven and mechanism models for well logging formation evaluation,explicitly focusing on predicting reservoir parameters,such as porosity and water saturation.Accurately interpreting these parameters is crucial for effectively exploring and developing oil and gas.However,with the increasing complexity of geological conditions in this industry,there is a growing demand for improved accuracy in reservoir parameter prediction,leading to higher costs associated with manual interpretation.The conventional logging interpretation methods rely on empirical relationships between logging data and reservoir parameters,which suffer from low interpretation efficiency,intense subjectivity,and suitability for ideal conditions.The application of artificial intelligence in the interpretation of logging data provides a new solution to the problems existing in traditional methods.It is expected to improve the accuracy and efficiency of the interpretation.If large and high-quality datasets exist,data-driven models can reveal relationships of arbitrary complexity.Nevertheless,constructing sufficiently large logging datasets with reliable labels remains challenging,making it difficult to apply data-driven models effectively in logging data interpretation.Furthermore,data-driven models often act as“black boxes”without explaining their predictions or ensuring compliance with primary physical constraints.This paper proposes a machine learning method with strong physical constraints by integrating mechanism and data-driven models.Prior knowledge of logging data interpretation is embedded into machine learning regarding network structure,loss function,and optimization algorithm.We employ the Physically Informed Auto-Encoder(PIAE)to predict porosity and water saturation,which can be trained without labeled reservoir parameters using self-supervised learning techniques.This approach effectively achieves automated interpretation and facilitates generalization across diverse datasets.
基金supported by the National Key Research and Development Program of China(2023YFB3307801)the National Natural Science Foundation of China(62394343,62373155,62073142)+3 种基金Major Science and Technology Project of Xinjiang(No.2022A01006-4)the Programme of Introducing Talents of Discipline to Universities(the 111 Project)under Grant B17017the Fundamental Research Funds for the Central Universities,Science Foundation of China University of Petroleum,Beijing(No.2462024YJRC011)the Open Research Project of the State Key Laboratory of Industrial Control Technology,China(Grant No.ICT2024B70).
文摘The distillation process is an important chemical process,and the application of data-driven modelling approach has the potential to reduce model complexity compared to mechanistic modelling,thus improving the efficiency of process optimization or monitoring studies.However,the distillation process is highly nonlinear and has multiple uncertainty perturbation intervals,which brings challenges to accurate data-driven modelling of distillation processes.This paper proposes a systematic data-driven modelling framework to solve these problems.Firstly,data segment variance was introduced into the K-means algorithm to form K-means data interval(KMDI)clustering in order to cluster the data into perturbed and steady state intervals for steady-state data extraction.Secondly,maximal information coefficient(MIC)was employed to calculate the nonlinear correlation between variables for removing redundant features.Finally,extreme gradient boosting(XGBoost)was integrated as the basic learner into adaptive boosting(AdaBoost)with the error threshold(ET)set to improve weights update strategy to construct the new integrated learning algorithm,XGBoost-AdaBoost-ET.The superiority of the proposed framework is verified by applying this data-driven modelling framework to a real industrial process of propylene distillation.
文摘The pH-sensitive hydrogels play a crucial role in applications such as soft robotics,drug delivery,and biomedical sensors,as they require precise control of swelling behaviors and stress distributions.Traditional experimental methods struggle to capture stress distributions due to technical limitations,while numerical approaches are often computationally intensive.This study presents a hybrid framework combining analytical modeling and machine learning(ML)to overcome these challenges.An analytical model is used to simulate transient swelling behaviors and stress distributions,and is confirmed to be viable through the comparison of the obtained simulation results with the existing experimental swelling data.The predictions from this model are used to train neural networks,including a two-step augmented architecture.The initial neural network predicts hydration values,which are then fed into a second network to predict stress distributions,effectively capturing nonlinear interdependencies.This approach achieves mean absolute errors(MAEs)as low as 0.031,with average errors of 1.9%for the radial stress and 2.55%for the hoop stress.This framework significantly enhances the predictive accuracy and reduces the computational complexity,offering actionable insights for optimizing hydrogel-based systems.
文摘Permanent magnet synchronous motor(PMSM)is widely used in alternating current servo systems as it provides high eficiency,high power density,and a wide speed regulation range.The servo system is placing higher demands on its control performance.The model predictive control(MPC)algorithm is emerging as a potential high-performance motor control algorithm due to its capability of handling multiple-input and multipleoutput variables and imposed constraints.For the MPC used in the PMSM control process,there is a nonlinear disturbance caused by the change of electromagnetic parameters or load disturbance that may lead to a mismatch between the nominal model and the controlled object,which causes the prediction error and thus affects the dynamic stability of the control system.This paper proposes a data-driven MPC strategy in which the historical data in an appropriate range are utilized to eliminate the impact of parameter mismatch and further improve the control performance.The stability of the proposed algorithm is proved as the simulation demonstrates the feasibility.Compared with the classical MPC strategy,the superiority of the algorithm has also been verified.
基金National Natural Science Foundation of China(Nos.42301473,42271424,42171397)Chinese Postdoctoral Innovation Talents Support Program(No.BX20230299)+2 种基金China Postdoctoral Science Foundation(No.2023M742884)Natural Science Foundation of Sichuan Province(Nos.24NSFSC2264,2025ZNSFSC0322)Key Research and Development Project of Sichuan Province(No.24ZDYF0633).
文摘As a key node of modern transportation network,the informationization management of road tunnels is crucial to ensure the operation safety and traffic efficiency.However,the existing tunnel vehicle modeling methods generally have problems such as insufficient 3D scene description capability and low dynamic update efficiency,which are difficult to meet the demand of real-time accurate management.For this reason,this paper proposes a vehicle twin modeling method for road tunnels.This approach starts from the actual management needs,and supports multi-level dynamic modeling from vehicle type,size to color by constructing a vehicle model library that can be flexibly invoked;at the same time,semantic constraint rules with geometric layout,behavioral attributes,and spatial relationships are designed to ensure that the virtual model matches with the real model with a high degree of similarity;ultimately,the prototype system is constructed and the case region is selected for the case study,and the dynamic vehicle status in the tunnel is realized by integrating real-time monitoring data with semantic constraints for precise virtual-real mapping.Finally,the prototype system is constructed and case experiments are conducted in selected case areas,which are combined with real-time monitoring data to realize dynamic updating and three-dimensional visualization of vehicle states in tunnels.The experiments show that the proposed method can run smoothly with an average rendering efficiency of 17.70 ms while guaranteeing the modeling accuracy(composite similarity of 0.867),which significantly improves the real-time and intuitive tunnel management.The research results provide reliable technical support for intelligent operation and emergency response of road tunnels,and offer new ideas for digital twin modeling of complex scenes.
文摘Using a dynamic laser monitoring technique,the solubility of 3-nitro-1,2,4-triazole-5-one(NTO)was investigated in two different binary systems,namely hydroxylamine nitrate(HAN)-water and boric acid(HB)-water ranging from 278.15 K to 318.15 K.The solubility in each system was found to be positively correlated with temperature.Furthermore,solubility data were analyzed using four equations:the modified Apelblat equation,Van’t Hoff equation,λh equation and CNIBS/R-K equations,and they provided satisfactory results for both two systems.The average root-mean-square deviation(105RMSD)values for these models were less than 13.93.Calculations utilizing the Van’t Hoff equation and Gibbs equations facilitated the derivation of apparent thermodynamic properties of NTO dissolution in the two systems,including values for Gibbs free energy,enthalpy and entropy.The%ζ_(H)is larger than%ζ_(TS),and all the%ζ_(H)data are≥58.63%,indicating that the enthalpy make a greater contribution than entropy to theΔG_(soln)^(Θ).
基金Supported by Gansu Province Joint Fund General Program,No.24JRRA878Gansu Provincial Science and Technology Program Project,No.24JRRA1020+2 种基金Gansu Province Key Talent Program,No.2025RCXM006Teaching Research and Reform Program for Postgraduate Education at Gansu University of Traditional Chinese Medicine(GUSTCM),No.YBXM-202406Special Fund for Mentors of“Qihuang Talents”in the First-Level Discipline of Chinese Medicine,No.ZYXKBD-202415。
文摘BACKGROUND Emerging evidence implicates Candida albicans(C.albicans)in human oncogenesis.Notably,studies have supported its involvement in regulating outcomes in colorectal cancer(CRC).This study investigated the paradoxical role of C.albicans in CRC,aiming to determine whether it promotes or suppresses tumor development,with a focus on the mechanistic basis linked to its metabolic profile.AIM To investigate the dual role of C.albicans in the development and progression of CRC through metabolite profiling and to establish a prognostic model that integrates the microbial and metabolic interactions in CRC,providing insights into potential therapeutic strategies and clinical outcomes.METHODSA prognostic model integrating C. albicans with CRC was developed, incorporating enrichment analysis, immuneinfiltration profiling, survival analysis, Mendelian randomization, single-cell sequencing, and spatial transcriptomics.The effects of the C. albicans metabolite mixture on CRC cells were subsequently validated in vitro. Theprimary metabolite composition was characterized using liquid chromatography-mass spectrometry.RESULTSA prognostic model based on five specific mRNA markers, EHD4, LIME1, GADD45B, TIMP1, and FDFT1, wasestablished. The C. albicans metabolite mixture significantly reduced CRC cell viability. Post-treatment analysisrevealed a significant decrease in gene expression in HT29 cells, while the expression levels of TIMP1, EHD4, andGADD45B were significantly elevated in HCT116 cells. Conversely, LIME1 expression and that of other CRC celllines showed reductions. In normal colonic epithelial cells (NCM460), GADD45B, TIMP1, and FDFT1 expressionlevels were significantly increased, while LIME1 and EHD4 levels were markedly reduced. Following metabolitetreatment, the invasive and migratory capabilities of NCM460, HT29, and HCT116 cells were reduced. Quantitativeanalysis of extracellular ATP post-treatment showed a significant elevation (P < 0.01). The C. albicans metabolitemixture had no effect on reactive oxygen species accumulation in CRC cells but led to a reduction in mitochondrialmembrane potential, increased intracellular lipid peroxidation, and induced apoptosis. Metabolomic profilingrevealed significant alterations, with 516 metabolites upregulated and 531 downregulated.CONCLUSIONThis study introduced a novel prognostic model for CRC risk assessment. The findings suggested that the C.albicans metabolite mixture exerted an inhibitory effect on CRC initiation.
