Multispecies ecological models have been used for predicting the effects of fishing activity and evaluating the performance of management strategies. Size-spectrum models are one type of physiologically-structured eco...Multispecies ecological models have been used for predicting the effects of fishing activity and evaluating the performance of management strategies. Size-spectrum models are one type of physiologically-structured ecological model that provide a feasible approach to describing fish communities in terms of individual dietary variation and ontogenetic niche shift. Despite the potential of ecological models in improving our understanding of ecosystems, their application is usually limited for data-poor fisheries. As a first step in implementing ecosystem-based fisheries management（EBFM）, this study built a size-spectrum model for the fish community in the Haizhou Bay, China. We describe data collection procedures and model parameterization to facilitate the implementation of such size-spectrum models for future studies of data-poor ecosystems. The effects of fishing on the ecosystem were exemplified with a range of fishing effort and were monitored with a set of ecological indicators. Total community biomass, biodiversity index, W-statistic, LFI（Large fish index）, Mean W（mean body weight） and Slope（slope of community size spectra） showed a strong non-linear pattern in response to fishing pressure, and largest fishing effort did not generate the most drastic responses in certain scenarios. We emphasize the value and feasibility of developing size-spectrum models to capture ecological dynamics and suggest limitations as well as potential for model improvement. This study aims to promote a wide use of this type of model in support of EBFM.展开更多
Comparing the city-size distribution at the urban agglomeration（UA） scale is important for understanding the processes of urban development. However, comparative studies of city-size distribution among China＇s thre...Comparing the city-size distribution at the urban agglomeration（UA） scale is important for understanding the processes of urban development. However, comparative studies of city-size distribution among China＇s three largest UAs, the Beijing-Tianjin-Hebei agglomeration（BTHA）, the Yangtze River Delta agglomeration（YRDA）, and the Pearl River Delta agglomeration（PRDA）, remain inadequate due to the limitation of data availability. Therefore, using urban data derived from time-series nighttime light data, the common characteristics and distinctive features of city-size distribution among the three UAs from 1992 to 2015 were compared by the Pareto regression and the rank clock method. We identified two common features. First, the city-size distribution became more even. The Pareto exponents increased by 0.17, 0.12, and 0.01 in the YRDA, BTHA, and PRDA, respectively. Second, the average ranks of small cities ascended, being 0.55, 0.08 and 0.04 in the three UAs, respectively. However, the average ranks of large and medium cities in the three UAs experienced different trajectories, which are closely related to the similarities and differences in the driving forces for the development of UAs. Place-based measures are encouraged to promote a coordinated development among cities of differing sizes in the three UAs.展开更多
Objective To develop methods for determining a suitable sample size for bioequivalence assessment of generic topical ophthalmic drugs using crossover design with serial sampling schemes.Methods The power functions of ...Objective To develop methods for determining a suitable sample size for bioequivalence assessment of generic topical ophthalmic drugs using crossover design with serial sampling schemes.Methods The power functions of the Fieller-type confidence interval and the asymptotic confidence interval in crossover designs with serial-sampling data are here derived.Simulation studies were conducted to evaluate the derived power functions.Results Simulation studies show that two power functions can provide precise power estimates when normality assumptions are satisfied and yield conservative estimates of power in cases when data are log-normally distributed.The intra-correlation showed a positive correlation with the power of the bioequivalence test.When the expected ratio of the AUCs was less than or equal to 1, the power of the Fieller-type confidence interval was larger than the asymptotic confidence interval.If the expected ratio of the AUCs was larger than 1, the asymptotic confidence interval had greater power.Sample size can be calculated through numerical iteration with the derived power functions.Conclusion The Fieller-type power function and the asymptotic power function can be used to determine sample sizes of crossover trials for bioequivalence assessment of topical ophthalmic drugs.展开更多
基金The Special Fund for Agriscientific Research in the Public Interest under contract No.201303050the Fundamental Research Funds for the Central Universities under contract Nos 201022001 and 201262004
文摘Multispecies ecological models have been used for predicting the effects of fishing activity and evaluating the performance of management strategies. Size-spectrum models are one type of physiologically-structured ecological model that provide a feasible approach to describing fish communities in terms of individual dietary variation and ontogenetic niche shift. Despite the potential of ecological models in improving our understanding of ecosystems, their application is usually limited for data-poor fisheries. As a first step in implementing ecosystem-based fisheries management（EBFM）, this study built a size-spectrum model for the fish community in the Haizhou Bay, China. We describe data collection procedures and model parameterization to facilitate the implementation of such size-spectrum models for future studies of data-poor ecosystems. The effects of fishing on the ecosystem were exemplified with a range of fishing effort and were monitored with a set of ecological indicators. Total community biomass, biodiversity index, W-statistic, LFI（Large fish index）, Mean W（mean body weight） and Slope（slope of community size spectra） showed a strong non-linear pattern in response to fishing pressure, and largest fishing effort did not generate the most drastic responses in certain scenarios. We emphasize the value and feasibility of developing size-spectrum models to capture ecological dynamics and suggest limitations as well as potential for model improvement. This study aims to promote a wide use of this type of model in support of EBFM.
基金National Natural Science Foundation of China,No.41621061,No.41501092 Talents Training Program from the Beijing Municipal Commission of Education No.201500002012G058
文摘Comparing the city-size distribution at the urban agglomeration（UA） scale is important for understanding the processes of urban development. However, comparative studies of city-size distribution among China＇s three largest UAs, the Beijing-Tianjin-Hebei agglomeration（BTHA）, the Yangtze River Delta agglomeration（YRDA）, and the Pearl River Delta agglomeration（PRDA）, remain inadequate due to the limitation of data availability. Therefore, using urban data derived from time-series nighttime light data, the common characteristics and distinctive features of city-size distribution among the three UAs from 1992 to 2015 were compared by the Pareto regression and the rank clock method. We identified two common features. First, the city-size distribution became more even. The Pareto exponents increased by 0.17, 0.12, and 0.01 in the YRDA, BTHA, and PRDA, respectively. Second, the average ranks of small cities ascended, being 0.55, 0.08 and 0.04 in the three UAs, respectively. However, the average ranks of large and medium cities in the three UAs experienced different trajectories, which are closely related to the similarities and differences in the driving forces for the development of UAs. Place-based measures are encouraged to promote a coordinated development among cities of differing sizes in the three UAs.
基金supported by sub-project of National Major Scientific and Technological Special Project of China for ‘Significant New Drugs Development’[2015ZX09501008-004]
文摘Objective To develop methods for determining a suitable sample size for bioequivalence assessment of generic topical ophthalmic drugs using crossover design with serial sampling schemes.Methods The power functions of the Fieller-type confidence interval and the asymptotic confidence interval in crossover designs with serial-sampling data are here derived.Simulation studies were conducted to evaluate the derived power functions.Results Simulation studies show that two power functions can provide precise power estimates when normality assumptions are satisfied and yield conservative estimates of power in cases when data are log-normally distributed.The intra-correlation showed a positive correlation with the power of the bioequivalence test.When the expected ratio of the AUCs was less than or equal to 1, the power of the Fieller-type confidence interval was larger than the asymptotic confidence interval.If the expected ratio of the AUCs was larger than 1, the asymptotic confidence interval had greater power.Sample size can be calculated through numerical iteration with the derived power functions.Conclusion The Fieller-type power function and the asymptotic power function can be used to determine sample sizes of crossover trials for bioequivalence assessment of topical ophthalmic drugs.
