Long-term levodopa administration can lead to the development of levodopa-induced dyskinesia.Gamma oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced dyskinesia.Cu...Long-term levodopa administration can lead to the development of levodopa-induced dyskinesia.Gamma oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced dyskinesia.Currently,studies have reported increased oscillation power in cases of levodopa-induced dyskinesia.However,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced dyskinesia.Furthermore,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is unclear.We found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s disease.Furthermore,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma flow.Administration of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum flow.However,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum direction.These findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.展开更多
This study presents a novel hybrid topology optimization and mold design framework that integrates process fitting,runner system optimization,and structural analysis to significantly enhance the performance of injecti...This study presents a novel hybrid topology optimization and mold design framework that integrates process fitting,runner system optimization,and structural analysis to significantly enhance the performance of injection-molded parts.At its core,the framework employs a greedy algorithm that generates runner systems based on adjacency and shortest path principles,leading to improvements in both mechanical strength and material efficiency.The design optimization is validated through a series of rigorous experimental tests,including three-point bending and torsion tests performed on key-socket frames,ensuring that the optimized designs meet practical performance requirements.A critical innovation of the framework is the development of the Adjacent Element Temperature-Driven Prestress Algorithm(AETDPA),which refines the prediction of mechanical failure and strength fitting.This algorithm has been shown to deliver mesh-independent accuracy,thereby enhancing the reliability of simulation results across various design iterations.The framework’s adaptability is further demonstrated by its ability to adjust optimization methods based on the unique geometry of each part,thus accelerating the overall design process while ensuring struc-tural integrity.In addition to its immediate applications in injection molding,the study explores the potential extension of this framework to metal additive manufacturing,opening new avenues for its use in advanced manufacturing technologies.Numerical simulations,including finite element analysis,support the experimental findings and confirm that the optimized designs provide a balanced combination of strength,durability,and efficiency.Furthermore,the integration challenges with existing injection molding practices are addressed,underscoring the framework’s scalability and industrial relevance.Overall,this hybrid topology optimization framework offers a computationally efficient and robust solution for advanced manufacturing applications,promising significant improvements in design efficiency,cost-effectiveness,and product performance.Future work will focus on further enhancing algorithm robustness and exploring additional applications across diverse manufacturing processes.展开更多
Vitamin D deficiency is disproportionately prevalent among overweight and obese children,with conventional explanations such as poor dietary intake or reduced sun exposure offering only partial insight.Emerging eviden...Vitamin D deficiency is disproportionately prevalent among overweight and obese children,with conventional explanations such as poor dietary intake or reduced sun exposure offering only partial insight.Emerging evidence reveals a multifactorial pathophysiology,including sequestration of vitamin D in adipose tissue,altered hepatic metabolism,diminished bioavailability,and inflammationinduced resistance at the tissue level.These mechanisms contribute to a functional deficiency,wherein serum 25-hydroxyvitamin D levels may remain suboptimal despite adequate intake or sun exposure.Obesity-related alterations in vitamin Dbinding proteins,receptor expression,and pro-inflammatory signaling further compromise biological activity.Current diagnostic criteria and supplementation guidelines do not fully reflect these physiological complexities,leading to underdiagnosis and insufficient treatment.Personalized approaches-incorporating higher,body composition-adjusted dosing and consideration of inflammatory status-are emerging as promising strategies to restore sufficiency and improve metabolic outcomes.While preliminary evidence supports the safety and efficacy of high-dose supplementation in this population,pediatric-specific clinical trials are lacking.This review synthesizes current understanding of the pathophysiological mechanisms underlying vitamin D deficiency in pediatric obesity and emphasizes the need for individualized,evidence-based interventions to optimize vitamin D status and overall health.展开更多
The development of digital twins for geotechnical structures necessitates the real-time updates of threedimensional(3D)virtual models(e.g.numerical finite element method(FEM)model)to accurately predict time-varying ge...The development of digital twins for geotechnical structures necessitates the real-time updates of threedimensional(3D)virtual models(e.g.numerical finite element method(FEM)model)to accurately predict time-varying geotechnical responses(e.g.consolidation settlement)in a 3D spatial domain.However,traditional 3D numerical model updating approaches are computationally prohibitive and therefore difficult to update the 3D responses in real time.To address these challenges,this study proposes a novel machine learning framework called sparse dictionary learning(T-3D-SDL)for real-time updating of time-varying 3D geotechnical responses.In T-3D-SDL,a concerned dataset(e.g.time-varying 3D settlement)is approximated as a linear superposition of dictionary atoms generated from 3D random FEM analyses.Field monitoring data are then used to identify non-trivial atoms and estimate their weights within a Bayesian framework for model updating and prediction.The proposed approach enables the real-time update of temporally varying settlements with a high 3D spatial resolution and quantified uncertainty as field monitoring data evolve.The proposed approach is illustrated using an embankment construction project.The results show that the proposed approach effectively improves settlement predictions along temporal and 3D spatial dimensions,with minimal latency(e.g.within minutes),as monitoring data appear.In addition,the proposed approach requires only a reasonably small number of 3D FEM model evaluations,avoids the use of widely adopted yet often criticized surrogate models,and effectively addresses the limitations(e.g.computational inefficiency)of existing 3D model updating approaches.展开更多
Specially shaped permanent magnet structures can satisfy the requirements of equipment with limited space or unique shapes.Thereby,these optimize the distribution of magnetic fields.However,traditional manufacturing m...Specially shaped permanent magnet structures can satisfy the requirements of equipment with limited space or unique shapes.Thereby,these optimize the distribution of magnetic fields.However,traditional manufacturing methods are limited by the mold design and insufficient material utilization.In this study,a polymer-based Nd_(2)Fe_(14)B(NdFeB)magnetic slurry was developed based on direct ink writing(DIW)3D printing technology.A rapidly volatilizable magnetic slurry was used to achieve 3D oriented controllable layering,thus realizing the direct molding fabrication of NdFeB permanent magnets with complex structures.By exploring and optimizing the 3D printing process parameters,specially shaped bonded NdFeB permanent magnet structures with high precision and shape fidelity were prepared.The test results indicated that the remnant magnetization of the printed magnets was proportional to the NdFeB content in the slurry,the coercivity closely matched that of the original powder,and the mechanical properties of the printed magnets were favorable.Building on this,a magnetically driven helical-structure robot was designed and printed to achieve stable motion in low-Reynolds-number fluids.This paper presents a new,low-cost solution for the room-temperature preparation of shape-bonded NdFeB permanent magnets.展开更多
Changshu Textile Machinery Works Co.,Ltd.was founded in 1958 and is a professional R&D and manufacturing enterprise of looms shedding device in China.The company's products cover three series of shedding devic...Changshu Textile Machinery Works Co.,Ltd.was founded in 1958 and is a professional R&D and manufacturing enterprise of looms shedding device in China.The company's products cover three series of shedding devices for looms(Dobby,Jacquard,Cam Motion),forming a series of products with electronic shedding devices as the main products,and mechanical shedding devices as the auxiliary products.D2876pro electronic dobby The D2876pro electronic dobby is a high-performance equipment designed for a maximum operating speed of 800rpm.It has 16 cams,and 12mm of pitch,with a high installation type.The shedding type is double lift and full clear open.Its maximum wefts is 12,800 and 100,000.It has a two-stage filtration lubrication with a gerotor pump oil recycle system,and it is suitable for water-jet looms.展开更多
In the context of global digital transformation and the rising prominence of maker education,this study explores the innovative integration of digital modeling technologies with traditional Nixing Pottery craftsmanshi...In the context of global digital transformation and the rising prominence of maker education,this study explores the innovative integration of digital modeling technologies with traditional Nixing Pottery craftsmanship.By constructing a teaching framework under maker education theory,the research investigates how 3D modeling,CAD design,and 3D printing technologies can empower learners to address challenges in cultural heritage preservation and artistic innovation.Through experimental teaching and case analysis,the study verifies that this integrated approach significantly enhances learners’digital literacy,creative thinking,and cultural identity while optimizing Nixing Pottery’s production processes and design possibilities.The findings contribute to theoretical models of technology-enhanced craft education and provide practical pathways for the digital transformation of intangible cultural heritage.展开更多
Digital technologies have become an integral part of complete denture restoration.With advancement in computer-aided design and computer-aided manufacturing(CAD/CAM),tools such as intraoral scanning,facial scanning,3D...Digital technologies have become an integral part of complete denture restoration.With advancement in computer-aided design and computer-aided manufacturing(CAD/CAM),tools such as intraoral scanning,facial scanning,3D printing,and numerical control machining are reshaping the workflow of complete denture restoration.Unlike conventional methods that rely heavily on clinical experience and manual techniques,digital technologies offer greater precision,predictability,and efficacy.They also streamline the process by reducing the number of patient visits and improving overall comfort.Despite these improvements,the clinical application of digital complete denture restoration still faces challenges that require further standardization.The major issues include appropriate case selection,establishing consistent digital workflows,and evaluating long-term outcomes.To address these challenges and provide clinical guidance for practitioners,this expert consensus outlines the principles,advantages,and limitations of digital complete denture technology.The aim of this review was to offer practical recommendations on indications,clinical procedures and precautions,evaluation metrics,and outcome assessment to support digital restoration of complete denture in clinical practice.展开更多
The centroid coordinate serves as a critical control parameter in motion systems,including aircraft,missiles,rockets,and drones,directly influencing their motion dynamics and control performance.Traditional methods fo...The centroid coordinate serves as a critical control parameter in motion systems,including aircraft,missiles,rockets,and drones,directly influencing their motion dynamics and control performance.Traditional methods for centroid measurement often necessitate custom equipment and specialized positioning devices,leading to high costs and limited accuracy.Here,we present a centroid measurement method that integrates 3D scanning technology,enabling accurate measurement of centroid across various types of objects without the need for specialized positioning fixtures.A theoretical framework for centroid measurement was established,which combined the principle of the multi-point weighing method with 3D scanning technology.The measurement accuracy was evaluated using a designed standard component.Experimental results demonstrate that the discrepancies between the theoretical and the measured centroid of a standard component with various materials and complex shapes in the X,Y,and Z directions are 0.003 mm,0.009 mm,and 0.105 mm,respectively,yielding a spatial deviation of 0.106 mm.Qualitative verification was conducted through experimental validation of three distinct types.They confirmed the reliability of the proposed method,which allowed for accurate centroid measurements of various products without requiring positioning fixtures.This advancement significantly broadened the applicability and scope of centroid measurement devices,offering new theoretical insights and methodologies for the measurement of complex parts and systems.展开更多
Brain organoids encompass a large collection of in vitro stem cell–derived 3D culture systems that aim to recapitulate multiple aspects of in vivo brain development and function.First,this review provides a brief int...Brain organoids encompass a large collection of in vitro stem cell–derived 3D culture systems that aim to recapitulate multiple aspects of in vivo brain development and function.First,this review provides a brief introduction to the current state-of-the-art for neuroectoderm brain organoid development,emphasizing their biggest advantages in comparison with classical two-dimensional cell cultures and animal models.However,despite their usefulness for developmental studies,a major limitation for most brain organoid models is the absence of contributing cell types from endodermal and mesodermal origin.As such,current research is highly investing towards the incorporation of a functional vasculature and the microglial immune component.In this review,we will specifically focus on the development of immune-competent brain organoids.By summarizing the different approaches applied to incorporate microglia,it is highlighted that immune-competent brain organoids are not only important for studying neuronal network formation,but also offer a clear future as a new tool to study inflammatory responses in vitro in 3D in a brainlike environment.Therefore,our main focus here is to provide a comprehensive overview of assays to measure microglial phenotype and function within brain organoids,with an outlook on how these findings could better understand neuronal network development or restoration,as well as the influence of physical stress on microglia-containing brain organoids.Finally,we would like to stress that even though the development of immune-competent brain organoids has largely evolved over the past decade,their full potential as a pre-clinical tool to study novel therapeutic approaches to halt or reduce inflammation-mediated neurodegeneration still needs to be explored and validated.展开更多
Nitrogen doping in chemical vapor deposition-derived ultrananocrystalline diamond(UNCD)films in-creases the electronic conductivity,yet its microstructural effects on electron transport are insufficiently understood.W...Nitrogen doping in chemical vapor deposition-derived ultrananocrystalline diamond(UNCD)films in-creases the electronic conductivity,yet its microstructural effects on electron transport are insufficiently understood.We investigated the formation of nitrogen-induced diaph-ite structures(hybrid diamond-graphite phases)and their role in changing the conductivity.Nitrogen doping in a hy-drogen-rich plasma environment promotes the emergence of unique sp^(3)-sp^(2)bonding interfaces,where diamond grains are covalently integrated with graphitic domains,facilitating a structure-driven electronic transition.High-resolution transmis-sion electron microscopy and selected area electron diffraction reveal five-fold,six-fold and twelve-fold symmetries,along with an atypical{200}crystallographic reflection,confirming diaphite formation in 5%and 10%N-doped UNCD films,while high-er doping levels(15%and 20%)result in extensive graphitization.Raman spectroscopy tracks the evolution of sp^(2)bonding with increasing nitrogen content,while atomic force microscopy and X-ray diffraction indicate a consistent diamond grain size of~8 nm.Cryogenic electronic transport measurements reveal a conductivity increase from 8.72 to 708 S/cm as the nitrogen dop-ing level increases from 5%to 20%,which is attributed to defect-mediated carrier transport and 3D weak localization.The res-ulting conductivity is three orders of magnitude higher than previously reported.These findings establish a direct correlation between diaphite structural polymorphism and tunable electronic properties in nitrogen-doped UNCD films,offering new ways for defect-engineering diamond-based electronic materials.展开更多
In dynamic 5G network environments,user mobility and heterogeneous network topologies pose dual challenges to the effort of improving performance of mobile edge caching.Existing studies often overlook the dynamic natu...In dynamic 5G network environments,user mobility and heterogeneous network topologies pose dual challenges to the effort of improving performance of mobile edge caching.Existing studies often overlook the dynamic nature of user locations and the potential of device-to-device(D2D)cooperative caching,limiting the reduction of transmission latency.To address this issue,this paper proposes a joint optimization scheme for edge caching that integrates user mobility prediction with deep reinforcement learning.First,a Transformer-based geolocation prediction model is designed,leveraging multi-head attention mechanisms to capture correlations in historical user trajectories for accurate future location prediction.Then,within a three-tier heterogeneous network,we formulate a latency minimization problem under a D2D cooperative caching architecture and develop a mobility-aware Deep Q-Network(DQN)caching strategy.This strategy takes predicted location information as state input and dynamically adjusts the content distribution across small base stations(SBSs)andmobile users(MUs)to reduce end-to-end delay inmulti-hop content retrieval.Simulation results show that the proposed DQN-based method outperforms other baseline strategies across variousmetrics,achieving a 17.2%reduction in transmission delay compared to DQNmethods withoutmobility integration,thus validating the effectiveness of the joint optimization of location prediction and caching decisions.展开更多
Vitamin D,beyond its classical role in calcium homeostasis,has emerged as a key regulator of immune function and epithelial barrier integrity.Its deficiency during early childhood—a critical period for immune maturat...Vitamin D,beyond its classical role in calcium homeostasis,has emerged as a key regulator of immune function and epithelial barrier integrity.Its deficiency during early childhood—a critical period for immune maturation—has been increasingly implicated in the development of atopic diseases.While extensively studied in asthma,its role in non-respiratory allergic conditions such as atopic dermatitis(AD)and allergic rhinitis(AR)remains comparatively underexplored.This minireview synthesizes current mechanistic and clinical evidence on vitamin D in pediatric AD and AR.In AD,vitamin D promotes epidermal barrier function through upregulation of filaggrin and ceramide synthesis,and enhances antimicrobial defense via induction of antimicrobial peptides.Observational studies consistently report lower serum 25-hydroxyvitamin D in affected children,particularly those with allergic sensitization.Select randomized controlled trials suggest clinical improvement with supplementation,especially at doses>2000 IU/day in deficient individuals.In AR,epidemiological data indicate stronger inverse associations with seasonal(pollen-induced)disease.Proposed mechanisms include modulation of dendritic cells,regulatory T cells,T helper 2 cytokines,and mucosal barrier integrity.The shared immunopathogenesis of AD and AR underscores vitamin D’s relevance.Although promising,clinical evidence remains heterogeneous.Future research should prioritize phenotype-stratified trials to clarify optimal dosing,timing,and individual response determinants,including genetics and microbiome composition.展开更多
The rise of smart wearable devices has driven the demand for flexible,high-performance optoelectronic devices with low power and easy high-density integration.Emerging Two-dimensional(2D)materials offer promising solu...The rise of smart wearable devices has driven the demand for flexible,high-performance optoelectronic devices with low power and easy high-density integration.Emerging Two-dimensional(2D)materials offer promising solutions.However,the use of 3D metal in traditional 2D devices often leads to Fermi-level pinning,compromising device performance.2D metallic materials,such as graphene and 2H-phase NbSe_(2),present a new avenue for addressing this issue and constructing high-performance,low-power photodetectors.In this work,we designed an all-2D asymmetric contacts photodetector using Gr and NbSe_(2)as electrodes for the 2D semiconductor WSe_(2).The asymmetric Schottky barriers and built-in electric fields facilitated by this architecture resulted in outstanding photovoltaic characteristics and self-powered photodetection.Under zero bias,the device exhibited a responsivity of 287 mA/W,a specific detectivity of 5.3×10^(11)Jones,and an external quantum efficiency of 88%.It also demonstrated an ultra-high light on/offratio(1.8×10^(5)),ultra-fast photoresponse speeds(80/72μs),broad-spectrum responsiveness(405980 nm),and exceptional cycling stability.The applications of the Gr/WSe_(2)/NbSe_(2)heterojunction in imaging and infrared optical communication have been explored,underscoring its significant potential.This work offers an idea to construct all-2D ultrathin optoelectronic devices.展开更多
Over the years,Hisense has formed an operation model that integrates production,sales and R&D globally,and built a global collaborative R&D system,which has laid a solid foundation for standardization.Hisense ...Over the years,Hisense has formed an operation model that integrates production,sales and R&D globally,and built a global collaborative R&D system,which has laid a solid foundation for standardization.Hisense keeps including advanced achievements and mature production experience in standards,injecting impetus into the innovation and high-quality development of the industry.展开更多
Despite numerous research investigations to understand the influences of various structural parameters,to the authors'knowledge,no research has been the effect of different angles of incidence on stab response and...Despite numerous research investigations to understand the influences of various structural parameters,to the authors'knowledge,no research has been the effect of different angles of incidence on stab response and performance of different types of protective textiles.Three distinct structures of 3D woven textiles and 2D plain weave fabric made with similar high-performance fiber and areal density were designed and manufactured to be tested.Two samples,one composed of a single and the other of 4-panel layers,from each fabric type structure,were prepared,and tested against stabbing at[0○],[22.5○],and[45○]angle of incidence.A new stabbing experimental setup that entertained testing of the specimens at various angles of incidence was engineered and utilized.The stabbing bench is also equipped with magnetic sensors and a UK Home Office Scientific Development Branch(HOSDB)/P1/B sharpness engineered knives to measure the impact velocity and exerted impact energy respectively.A silicon compound was utilized to imprint the Back Face Signature(BFS)on the backing material after every specimen test.Each silicon print was then scanned,digitized,and precisely measured to evaluate the stab response and performance of the specimen based on different performance variables,including Depth of Trauma(DOT),Depth of Penetration(DOP),and Length of Penetration(LOP).Besides,the post-impact surface failure modes of the fabrics were also measured using Image software and analyzed at the microscale level.The results show stab angle of incidence greatly influences the stab response and performance of protective textiles.The outcome of the study could provide not only valuable insights into understanding the stab response and capabilities of protective textiles under different angle of incidence,but also provide valuable information for protective textile manufacturer,armor developer and stab testing and standardizing organizations to consider the angle of incidence while developing,testing,optimizing,and using protective textiles in various applications.展开更多
Although anisotropic NMR spectroscopy has emerged as a powerful method for determining the relative configuration of complex natural products,major challenges persist with structurally flexible molecules.In this study...Although anisotropic NMR spectroscopy has emerged as a powerful method for determining the relative configuration of complex natural products,major challenges persist with structurally flexible molecules.In this study,we conducted a system-atic comparative analysis of stereochemical elucidation,combining anisotropic NMR spectroscopy and density functional theory(DFT)calculations on spiroepicoccin B(1)and epicoccin V(2),which were characterized as thiodiketopiperazine marine natural products isolated from the deep-sea-derived fungus Epicoccum nigrum SD-388.For the flexible compound 2,we compared various conformational sampling approaches,including an assessment of the quality of relative energies within the obtained ensembles.We demonstrated the critical role of dispersion correction within DFT computations to precisely account for weak non-bonded intramolecular interactions.By integrating anisotropic NMR analysis,chemical shifts,elec-tronic circular dichroism,and DFT computations,we determined the absolute configurations and conformational ensembles for 1 and 2,respectively,highlighting the significance of the intramolecular methyl-πinteraction in stabilizing one of the conformers.Our study introduces new strategies to address conformational flexibility in the stereochemical elucidation of challenging organic molecules.展开更多
Object detection in occluded environments remains a core challenge in computer vision(CV),especially in domains such as autonomous driving and robotics.While Convolutional Neural Network(CNN)-based twodimensional(2D)a...Object detection in occluded environments remains a core challenge in computer vision(CV),especially in domains such as autonomous driving and robotics.While Convolutional Neural Network(CNN)-based twodimensional(2D)and three-dimensional(3D)object detection methods havemade significant progress,they often fall short under severe occlusion due to depth ambiguities in 2D imagery and the high cost and deployment limitations of 3D sensors such as Light Detection and Ranging(LiDAR).This paper presents a comparative review of recent 2D and 3D detection models,focusing on their occlusion-handling capabilities and the impact of sensor modalities such as stereo vision,Time-of-Flight(ToF)cameras,and LiDAR.In this context,we introduce FuDensityNet,our multimodal occlusion-aware detection framework that combines Red-Green-Blue(RGB)images and LiDAR data to enhance detection performance.As a forward-looking direction,we propose a monocular depth-estimation extension to FuDensityNet,aimed at replacing expensive 3D sensors with a more scalable CNN-based pipeline.Although this enhancement is not experimentally evaluated in this manuscript,we describe its conceptual design and potential for future implementation.展开更多
Schistosomiasis is a neglected tropical disease (NTD) widespread in sub-Saharan Africa and mostly affects school going children. Côte d’Ivoire is one of the most vulnerable countries to schistosomiasis, and its ...Schistosomiasis is a neglected tropical disease (NTD) widespread in sub-Saharan Africa and mostly affects school going children. Côte d’Ivoire is one of the most vulnerable countries to schistosomiasis, and its prevalence varies by region. This cross-sectional survey was conducted in schools in the Upper Sassandra region to determine the knowledge, attitude, and practices of school children regarding schistosomiasis. In total, 354 students participated in the survey. Our results showed that, compared to the girls, the boys had a higher level of knowledge about schistosomiasis OR = 1.605 and p = 0.05. Regarding the signs, symptoms, and modes of transmission and prevention of schistosomiasis, the participants reported a low level of knowledge p > 0.05 and OR 1. In conclusion, it is important to target health messages in schools to reach the most vulnerable students effectively. This initiative aims to provide children with basic knowledge and skills in the transmission of schistosomiasis.展开更多
基金supported by the National Natural Science Foundation of China,No.82071254(to WZ).
文摘Long-term levodopa administration can lead to the development of levodopa-induced dyskinesia.Gamma oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced dyskinesia.Currently,studies have reported increased oscillation power in cases of levodopa-induced dyskinesia.However,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced dyskinesia.Furthermore,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is unclear.We found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s disease.Furthermore,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma flow.Administration of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum flow.However,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum direction.These findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.
文摘This study presents a novel hybrid topology optimization and mold design framework that integrates process fitting,runner system optimization,and structural analysis to significantly enhance the performance of injection-molded parts.At its core,the framework employs a greedy algorithm that generates runner systems based on adjacency and shortest path principles,leading to improvements in both mechanical strength and material efficiency.The design optimization is validated through a series of rigorous experimental tests,including three-point bending and torsion tests performed on key-socket frames,ensuring that the optimized designs meet practical performance requirements.A critical innovation of the framework is the development of the Adjacent Element Temperature-Driven Prestress Algorithm(AETDPA),which refines the prediction of mechanical failure and strength fitting.This algorithm has been shown to deliver mesh-independent accuracy,thereby enhancing the reliability of simulation results across various design iterations.The framework’s adaptability is further demonstrated by its ability to adjust optimization methods based on the unique geometry of each part,thus accelerating the overall design process while ensuring struc-tural integrity.In addition to its immediate applications in injection molding,the study explores the potential extension of this framework to metal additive manufacturing,opening new avenues for its use in advanced manufacturing technologies.Numerical simulations,including finite element analysis,support the experimental findings and confirm that the optimized designs provide a balanced combination of strength,durability,and efficiency.Furthermore,the integration challenges with existing injection molding practices are addressed,underscoring the framework’s scalability and industrial relevance.Overall,this hybrid topology optimization framework offers a computationally efficient and robust solution for advanced manufacturing applications,promising significant improvements in design efficiency,cost-effectiveness,and product performance.Future work will focus on further enhancing algorithm robustness and exploring additional applications across diverse manufacturing processes.
文摘Vitamin D deficiency is disproportionately prevalent among overweight and obese children,with conventional explanations such as poor dietary intake or reduced sun exposure offering only partial insight.Emerging evidence reveals a multifactorial pathophysiology,including sequestration of vitamin D in adipose tissue,altered hepatic metabolism,diminished bioavailability,and inflammationinduced resistance at the tissue level.These mechanisms contribute to a functional deficiency,wherein serum 25-hydroxyvitamin D levels may remain suboptimal despite adequate intake or sun exposure.Obesity-related alterations in vitamin Dbinding proteins,receptor expression,and pro-inflammatory signaling further compromise biological activity.Current diagnostic criteria and supplementation guidelines do not fully reflect these physiological complexities,leading to underdiagnosis and insufficient treatment.Personalized approaches-incorporating higher,body composition-adjusted dosing and consideration of inflammatory status-are emerging as promising strategies to restore sufficiency and improve metabolic outcomes.While preliminary evidence supports the safety and efficacy of high-dose supplementation in this population,pediatric-specific clinical trials are lacking.This review synthesizes current understanding of the pathophysiological mechanisms underlying vitamin D deficiency in pediatric obesity and emphasizes the need for individualized,evidence-based interventions to optimize vitamin D status and overall health.
基金supported by a grant from the Research Grant Council of Hong Kong Special Administrative Region(Project No.11207724).
文摘The development of digital twins for geotechnical structures necessitates the real-time updates of threedimensional(3D)virtual models(e.g.numerical finite element method(FEM)model)to accurately predict time-varying geotechnical responses(e.g.consolidation settlement)in a 3D spatial domain.However,traditional 3D numerical model updating approaches are computationally prohibitive and therefore difficult to update the 3D responses in real time.To address these challenges,this study proposes a novel machine learning framework called sparse dictionary learning(T-3D-SDL)for real-time updating of time-varying 3D geotechnical responses.In T-3D-SDL,a concerned dataset(e.g.time-varying 3D settlement)is approximated as a linear superposition of dictionary atoms generated from 3D random FEM analyses.Field monitoring data are then used to identify non-trivial atoms and estimate their weights within a Bayesian framework for model updating and prediction.The proposed approach enables the real-time update of temporally varying settlements with a high 3D spatial resolution and quantified uncertainty as field monitoring data evolve.The proposed approach is illustrated using an embankment construction project.The results show that the proposed approach effectively improves settlement predictions along temporal and 3D spatial dimensions,with minimal latency(e.g.within minutes),as monitoring data appear.In addition,the proposed approach requires only a reasonably small number of 3D FEM model evaluations,avoids the use of widely adopted yet often criticized surrogate models,and effectively addresses the limitations(e.g.computational inefficiency)of existing 3D model updating approaches.
基金supported by National Natural Science Foundation of China(Grant Nos.52375348,52175331)National Natural Science Foundation of Shandong Province(Grant Nos.ZR2022ME014,ZR2020ZD04).
文摘Specially shaped permanent magnet structures can satisfy the requirements of equipment with limited space or unique shapes.Thereby,these optimize the distribution of magnetic fields.However,traditional manufacturing methods are limited by the mold design and insufficient material utilization.In this study,a polymer-based Nd_(2)Fe_(14)B(NdFeB)magnetic slurry was developed based on direct ink writing(DIW)3D printing technology.A rapidly volatilizable magnetic slurry was used to achieve 3D oriented controllable layering,thus realizing the direct molding fabrication of NdFeB permanent magnets with complex structures.By exploring and optimizing the 3D printing process parameters,specially shaped bonded NdFeB permanent magnet structures with high precision and shape fidelity were prepared.The test results indicated that the remnant magnetization of the printed magnets was proportional to the NdFeB content in the slurry,the coercivity closely matched that of the original powder,and the mechanical properties of the printed magnets were favorable.Building on this,a magnetically driven helical-structure robot was designed and printed to achieve stable motion in low-Reynolds-number fluids.This paper presents a new,low-cost solution for the room-temperature preparation of shape-bonded NdFeB permanent magnets.
文摘Changshu Textile Machinery Works Co.,Ltd.was founded in 1958 and is a professional R&D and manufacturing enterprise of looms shedding device in China.The company's products cover three series of shedding devices for looms(Dobby,Jacquard,Cam Motion),forming a series of products with electronic shedding devices as the main products,and mechanical shedding devices as the auxiliary products.D2876pro electronic dobby The D2876pro electronic dobby is a high-performance equipment designed for a maximum operating speed of 800rpm.It has 16 cams,and 12mm of pitch,with a high installation type.The shedding type is double lift and full clear open.Its maximum wefts is 12,800 and 100,000.It has a two-stage filtration lubrication with a gerotor pump oil recycle system,and it is suitable for water-jet looms.
文摘In the context of global digital transformation and the rising prominence of maker education,this study explores the innovative integration of digital modeling technologies with traditional Nixing Pottery craftsmanship.By constructing a teaching framework under maker education theory,the research investigates how 3D modeling,CAD design,and 3D printing technologies can empower learners to address challenges in cultural heritage preservation and artistic innovation.Through experimental teaching and case analysis,the study verifies that this integrated approach significantly enhances learners’digital literacy,creative thinking,and cultural identity while optimizing Nixing Pottery’s production processes and design possibilities.The findings contribute to theoretical models of technology-enhanced craft education and provide practical pathways for the digital transformation of intangible cultural heritage.
基金supported by National Natural Science Foundation of China(82325012)General project of State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration(2024MS05).
文摘Digital technologies have become an integral part of complete denture restoration.With advancement in computer-aided design and computer-aided manufacturing(CAD/CAM),tools such as intraoral scanning,facial scanning,3D printing,and numerical control machining are reshaping the workflow of complete denture restoration.Unlike conventional methods that rely heavily on clinical experience and manual techniques,digital technologies offer greater precision,predictability,and efficacy.They also streamline the process by reducing the number of patient visits and improving overall comfort.Despite these improvements,the clinical application of digital complete denture restoration still faces challenges that require further standardization.The major issues include appropriate case selection,establishing consistent digital workflows,and evaluating long-term outcomes.To address these challenges and provide clinical guidance for practitioners,this expert consensus outlines the principles,advantages,and limitations of digital complete denture technology.The aim of this review was to offer practical recommendations on indications,clinical procedures and precautions,evaluation metrics,and outcome assessment to support digital restoration of complete denture in clinical practice.
基金supported by National Natural Science Foundation of China(No.52176122).
文摘The centroid coordinate serves as a critical control parameter in motion systems,including aircraft,missiles,rockets,and drones,directly influencing their motion dynamics and control performance.Traditional methods for centroid measurement often necessitate custom equipment and specialized positioning devices,leading to high costs and limited accuracy.Here,we present a centroid measurement method that integrates 3D scanning technology,enabling accurate measurement of centroid across various types of objects without the need for specialized positioning fixtures.A theoretical framework for centroid measurement was established,which combined the principle of the multi-point weighing method with 3D scanning technology.The measurement accuracy was evaluated using a designed standard component.Experimental results demonstrate that the discrepancies between the theoretical and the measured centroid of a standard component with various materials and complex shapes in the X,Y,and Z directions are 0.003 mm,0.009 mm,and 0.105 mm,respectively,yielding a spatial deviation of 0.106 mm.Qualitative verification was conducted through experimental validation of three distinct types.They confirmed the reliability of the proposed method,which allowed for accurate centroid measurements of various products without requiring positioning fixtures.This advancement significantly broadened the applicability and scope of centroid measurement devices,offering new theoretical insights and methodologies for the measurement of complex parts and systems.
基金funded by the European Union’s Horizon 2020 research and innovation programme under the Marie Skodowska-Curie grant agreement No.813263(PMSMat Train,granted to UF,PP,MV,and DP)provided by the Fund for Scientific Research Flanders(FWO-Vlaanderen)of the Flemish Government(FWO sabbatical bench fee K800224N granted to PP)and ERA-NET Re Park(granted to PP)。
文摘Brain organoids encompass a large collection of in vitro stem cell–derived 3D culture systems that aim to recapitulate multiple aspects of in vivo brain development and function.First,this review provides a brief introduction to the current state-of-the-art for neuroectoderm brain organoid development,emphasizing their biggest advantages in comparison with classical two-dimensional cell cultures and animal models.However,despite their usefulness for developmental studies,a major limitation for most brain organoid models is the absence of contributing cell types from endodermal and mesodermal origin.As such,current research is highly investing towards the incorporation of a functional vasculature and the microglial immune component.In this review,we will specifically focus on the development of immune-competent brain organoids.By summarizing the different approaches applied to incorporate microglia,it is highlighted that immune-competent brain organoids are not only important for studying neuronal network formation,but also offer a clear future as a new tool to study inflammatory responses in vitro in 3D in a brainlike environment.Therefore,our main focus here is to provide a comprehensive overview of assays to measure microglial phenotype and function within brain organoids,with an outlook on how these findings could better understand neuronal network development or restoration,as well as the influence of physical stress on microglia-containing brain organoids.Finally,we would like to stress that even though the development of immune-competent brain organoids has largely evolved over the past decade,their full potential as a pre-clinical tool to study novel therapeutic approaches to halt or reduce inflammation-mediated neurodegeneration still needs to be explored and validated.
文摘Nitrogen doping in chemical vapor deposition-derived ultrananocrystalline diamond(UNCD)films in-creases the electronic conductivity,yet its microstructural effects on electron transport are insufficiently understood.We investigated the formation of nitrogen-induced diaph-ite structures(hybrid diamond-graphite phases)and their role in changing the conductivity.Nitrogen doping in a hy-drogen-rich plasma environment promotes the emergence of unique sp^(3)-sp^(2)bonding interfaces,where diamond grains are covalently integrated with graphitic domains,facilitating a structure-driven electronic transition.High-resolution transmis-sion electron microscopy and selected area electron diffraction reveal five-fold,six-fold and twelve-fold symmetries,along with an atypical{200}crystallographic reflection,confirming diaphite formation in 5%and 10%N-doped UNCD films,while high-er doping levels(15%and 20%)result in extensive graphitization.Raman spectroscopy tracks the evolution of sp^(2)bonding with increasing nitrogen content,while atomic force microscopy and X-ray diffraction indicate a consistent diamond grain size of~8 nm.Cryogenic electronic transport measurements reveal a conductivity increase from 8.72 to 708 S/cm as the nitrogen dop-ing level increases from 5%to 20%,which is attributed to defect-mediated carrier transport and 3D weak localization.The res-ulting conductivity is three orders of magnitude higher than previously reported.These findings establish a direct correlation between diaphite structural polymorphism and tunable electronic properties in nitrogen-doped UNCD films,offering new ways for defect-engineering diamond-based electronic materials.
基金supported by the Liaoning Provincial Education Department Fund,grant number JYTZD2023083.
文摘In dynamic 5G network environments,user mobility and heterogeneous network topologies pose dual challenges to the effort of improving performance of mobile edge caching.Existing studies often overlook the dynamic nature of user locations and the potential of device-to-device(D2D)cooperative caching,limiting the reduction of transmission latency.To address this issue,this paper proposes a joint optimization scheme for edge caching that integrates user mobility prediction with deep reinforcement learning.First,a Transformer-based geolocation prediction model is designed,leveraging multi-head attention mechanisms to capture correlations in historical user trajectories for accurate future location prediction.Then,within a three-tier heterogeneous network,we formulate a latency minimization problem under a D2D cooperative caching architecture and develop a mobility-aware Deep Q-Network(DQN)caching strategy.This strategy takes predicted location information as state input and dynamically adjusts the content distribution across small base stations(SBSs)andmobile users(MUs)to reduce end-to-end delay inmulti-hop content retrieval.Simulation results show that the proposed DQN-based method outperforms other baseline strategies across variousmetrics,achieving a 17.2%reduction in transmission delay compared to DQNmethods withoutmobility integration,thus validating the effectiveness of the joint optimization of location prediction and caching decisions.
文摘Vitamin D,beyond its classical role in calcium homeostasis,has emerged as a key regulator of immune function and epithelial barrier integrity.Its deficiency during early childhood—a critical period for immune maturation—has been increasingly implicated in the development of atopic diseases.While extensively studied in asthma,its role in non-respiratory allergic conditions such as atopic dermatitis(AD)and allergic rhinitis(AR)remains comparatively underexplored.This minireview synthesizes current mechanistic and clinical evidence on vitamin D in pediatric AD and AR.In AD,vitamin D promotes epidermal barrier function through upregulation of filaggrin and ceramide synthesis,and enhances antimicrobial defense via induction of antimicrobial peptides.Observational studies consistently report lower serum 25-hydroxyvitamin D in affected children,particularly those with allergic sensitization.Select randomized controlled trials suggest clinical improvement with supplementation,especially at doses>2000 IU/day in deficient individuals.In AR,epidemiological data indicate stronger inverse associations with seasonal(pollen-induced)disease.Proposed mechanisms include modulation of dendritic cells,regulatory T cells,T helper 2 cytokines,and mucosal barrier integrity.The shared immunopathogenesis of AD and AR underscores vitamin D’s relevance.Although promising,clinical evidence remains heterogeneous.Future research should prioritize phenotype-stratified trials to clarify optimal dosing,timing,and individual response determinants,including genetics and microbiome composition.
基金Liming Gao acknowledges funding from the National Natural Science Foundation of China(No.61727805).
文摘The rise of smart wearable devices has driven the demand for flexible,high-performance optoelectronic devices with low power and easy high-density integration.Emerging Two-dimensional(2D)materials offer promising solutions.However,the use of 3D metal in traditional 2D devices often leads to Fermi-level pinning,compromising device performance.2D metallic materials,such as graphene and 2H-phase NbSe_(2),present a new avenue for addressing this issue and constructing high-performance,low-power photodetectors.In this work,we designed an all-2D asymmetric contacts photodetector using Gr and NbSe_(2)as electrodes for the 2D semiconductor WSe_(2).The asymmetric Schottky barriers and built-in electric fields facilitated by this architecture resulted in outstanding photovoltaic characteristics and self-powered photodetection.Under zero bias,the device exhibited a responsivity of 287 mA/W,a specific detectivity of 5.3×10^(11)Jones,and an external quantum efficiency of 88%.It also demonstrated an ultra-high light on/offratio(1.8×10^(5)),ultra-fast photoresponse speeds(80/72μs),broad-spectrum responsiveness(405980 nm),and exceptional cycling stability.The applications of the Gr/WSe_(2)/NbSe_(2)heterojunction in imaging and infrared optical communication have been explored,underscoring its significant potential.This work offers an idea to construct all-2D ultrathin optoelectronic devices.
文摘Over the years,Hisense has formed an operation model that integrates production,sales and R&D globally,and built a global collaborative R&D system,which has laid a solid foundation for standardization.Hisense keeps including advanced achievements and mature production experience in standards,injecting impetus into the innovation and high-quality development of the industry.
文摘Despite numerous research investigations to understand the influences of various structural parameters,to the authors'knowledge,no research has been the effect of different angles of incidence on stab response and performance of different types of protective textiles.Three distinct structures of 3D woven textiles and 2D plain weave fabric made with similar high-performance fiber and areal density were designed and manufactured to be tested.Two samples,one composed of a single and the other of 4-panel layers,from each fabric type structure,were prepared,and tested against stabbing at[0○],[22.5○],and[45○]angle of incidence.A new stabbing experimental setup that entertained testing of the specimens at various angles of incidence was engineered and utilized.The stabbing bench is also equipped with magnetic sensors and a UK Home Office Scientific Development Branch(HOSDB)/P1/B sharpness engineered knives to measure the impact velocity and exerted impact energy respectively.A silicon compound was utilized to imprint the Back Face Signature(BFS)on the backing material after every specimen test.Each silicon print was then scanned,digitized,and precisely measured to evaluate the stab response and performance of the specimen based on different performance variables,including Depth of Trauma(DOT),Depth of Penetration(DOP),and Length of Penetration(LOP).Besides,the post-impact surface failure modes of the fabrics were also measured using Image software and analyzed at the microscale level.The results show stab angle of incidence greatly influences the stab response and performance of protective textiles.The outcome of the study could provide not only valuable insights into understanding the stab response and capabilities of protective textiles under different angle of incidence,but also provide valuable information for protective textile manufacturer,armor developer and stab testing and standardizing organizations to consider the angle of incidence while developing,testing,optimizing,and using protective textiles in various applications.
基金supported by the Leibniz-Forschungsinstitut für Molekulare Pharmakologie(FMP)and the Deutsche Forschungsgemeinschaft(DFG,German Research Foun-dation)under RTG 2473 Bioactive Peptides(392923329)A.F.K.and H.S.under Germany’s Excellence Strategy-EXC 2008/1(UniSysCat,390540038)to C.J.S.and H.S.+2 种基金the National Natural Science Foundation of China(U2006203)to B.-G.W.X.-L.Lsupport from the Taishan Scholars Program(tsqn202306366,China).A.N.-Vthanks National Council for Scien-tific and Technological Development(CNPq)for a research fellowship(309873/2023-1).
文摘Although anisotropic NMR spectroscopy has emerged as a powerful method for determining the relative configuration of complex natural products,major challenges persist with structurally flexible molecules.In this study,we conducted a system-atic comparative analysis of stereochemical elucidation,combining anisotropic NMR spectroscopy and density functional theory(DFT)calculations on spiroepicoccin B(1)and epicoccin V(2),which were characterized as thiodiketopiperazine marine natural products isolated from the deep-sea-derived fungus Epicoccum nigrum SD-388.For the flexible compound 2,we compared various conformational sampling approaches,including an assessment of the quality of relative energies within the obtained ensembles.We demonstrated the critical role of dispersion correction within DFT computations to precisely account for weak non-bonded intramolecular interactions.By integrating anisotropic NMR analysis,chemical shifts,elec-tronic circular dichroism,and DFT computations,we determined the absolute configurations and conformational ensembles for 1 and 2,respectively,highlighting the significance of the intramolecular methyl-πinteraction in stabilizing one of the conformers.Our study introduces new strategies to address conformational flexibility in the stereochemical elucidation of challenging organic molecules.
文摘Object detection in occluded environments remains a core challenge in computer vision(CV),especially in domains such as autonomous driving and robotics.While Convolutional Neural Network(CNN)-based twodimensional(2D)and three-dimensional(3D)object detection methods havemade significant progress,they often fall short under severe occlusion due to depth ambiguities in 2D imagery and the high cost and deployment limitations of 3D sensors such as Light Detection and Ranging(LiDAR).This paper presents a comparative review of recent 2D and 3D detection models,focusing on their occlusion-handling capabilities and the impact of sensor modalities such as stereo vision,Time-of-Flight(ToF)cameras,and LiDAR.In this context,we introduce FuDensityNet,our multimodal occlusion-aware detection framework that combines Red-Green-Blue(RGB)images and LiDAR data to enhance detection performance.As a forward-looking direction,we propose a monocular depth-estimation extension to FuDensityNet,aimed at replacing expensive 3D sensors with a more scalable CNN-based pipeline.Although this enhancement is not experimentally evaluated in this manuscript,we describe its conceptual design and potential for future implementation.
文摘Schistosomiasis is a neglected tropical disease (NTD) widespread in sub-Saharan Africa and mostly affects school going children. Côte d’Ivoire is one of the most vulnerable countries to schistosomiasis, and its prevalence varies by region. This cross-sectional survey was conducted in schools in the Upper Sassandra region to determine the knowledge, attitude, and practices of school children regarding schistosomiasis. In total, 354 students participated in the survey. Our results showed that, compared to the girls, the boys had a higher level of knowledge about schistosomiasis OR = 1.605 and p = 0.05. Regarding the signs, symptoms, and modes of transmission and prevention of schistosomiasis, the participants reported a low level of knowledge p > 0.05 and OR 1. In conclusion, it is important to target health messages in schools to reach the most vulnerable students effectively. This initiative aims to provide children with basic knowledge and skills in the transmission of schistosomiasis.
