At present,the aeration-assisted cutting-carrying technology is faced with complexities in the drilling of CBM multi-branch horizontal wells.For example,the aerating pressure is hardly maintained,and the borehole inst...At present,the aeration-assisted cutting-carrying technology is faced with complexities in the drilling of CBM multi-branch horizontal wells.For example,the aerating pressure is hardly maintained,and the borehole instability may happen.In view of these prominent problems,the technology of double casing tubes&a binary cycle system suitable for CBM multi-branch horizontal wells was developed according to the Venturi principle by means of parasitic tube insufflation which is used for well control simulation system.Then,a multiphase flow finite element model was established for the fluid-cutting particle system in this drilling condition.This technology was tested in field.Double-casing tubes cementing is adopted in this technology and a jet generator is installed at the bottom of the inner casing.In the process of drilling,the drilling fluid injected through double intermediate casing annulus is converted by the jet generator into a high-efficiency steering water jet,which,together with the water jet generated by the bit nozzle,increases the fluid returning rate in the inner annulus space.It is indicated from simulation results that the cutting-carrying effect is the best when the included angle between the nozzle of the jet generator and the vertical direction is 30°.Besides,the influential laws of cutting size,primary cycle volume,accessory cycle volume and drilling velocity on hole cleaning are figured out.It is concluded that this technology increases the flow rate of drilling fluid in annulus space,the returning rate of drilling fluid significantly and the cutting-carrying capacity.It is currently one of the effective hole cleaning technologies for CBM multi-branch horizontal wells where fresh water is taken as the drilling fluid.展开更多
Abstract--Vapor compression refrigeration cycle （VCC） system is a high dimensional coupling thermodynamic system for which the controller design is a great challenge. In this paper, a model predictive control based ...Abstract--Vapor compression refrigeration cycle （VCC） system is a high dimensional coupling thermodynamic system for which the controller design is a great challenge. In this paper, a model predictive control based energy efficient control strategy which aims at maximizing the system efficiency is proposed. Firstly, according to the mass and energy conservation law, an analysis on the nonlinear relationship between superheat and cooling load is carried out, which can produce the maximal effect on the system performance. Then a model predictive control （MPC） based controller is developed for tracking the calculated setting curve of superheat degree and pressure difference based on model identified from data which can be obtained from an experimental rig. The proposed control strategy maximizes the coefficient of performance （COP） which depends on operating conditions, in the meantime, it meets the changing demands of cooling capacity. The effectiveness of the control performance is validated on the experimental rig. Index Terms--Cooling load, model predictive control （MPC）, superheat, vapor compression refrigeration cycle （VCC）.展开更多
According to the problem that the selection of traditional PID control parameters is too complicated in evaporator of Organic Rankine Cycle system(ORC),an evaporator PID controller based on BP neural netw ork optimiza...According to the problem that the selection of traditional PID control parameters is too complicated in evaporator of Organic Rankine Cycle system(ORC),an evaporator PID controller based on BP neural netw ork optimization is designed. Based on the control theory,the model of ORC evaporator is set up. The BP algorithm is used to control the Kp,Kiand Kdparameters of the evaporator PID controller,so that the evaporator temperature can reach the optimal state quickly and steadily. The M ATLAB softw are is used to simulate the traditional PID controller and the BP neural netw ork PID controller. The experimental results show that the Kp,Kiand Kdparameters of the BP neural netw ork PID controller are 0. 5677,0. 2970,and 0. 1353,respectively.Therefore,the evaporator PID controller based on BP neural netw ork optimization not only satisfies the requirements of the system performance,but also has better control parameters than the traditional PID controller.展开更多
The use of nanorefrigerants in Organic Rankine Cycle(ORC)units is believed to affect the cycle environment performance,but backed with very few relevant studies.For this purpose,a life cycle assessment(LCA)has been pe...The use of nanorefrigerants in Organic Rankine Cycle(ORC)units is believed to affect the cycle environment performance,but backed with very few relevant studies.For this purpose,a life cycle assessment(LCA)has been performed for the ORC system using nanorefrigerant,the material and energy input,characteristic indicators and comprehensive index of environmental impact,total energy consumption and energy payback time(BPBT)of the whole life cycle of ORC system using Al_(2)O_(3)/R141b nanorefrigerant were calculated.Total environmental comprehensive indexes reveal that ECER-135 index decrease by 1.5%after adding 0.2%Al_(2)O_(3)nanoparticles to R141b.Based on the contribution analysis and sensitivity analysis,it can be found out ORC system manufacturing is of the most critical stage,where,the ECER-135 index of ORC component production is the greatest,followed by the preparation process of R141b,transportation phase,and that of Al_(2)O_(3)nanoparticles preparation is small.The retirement phase which has good environmental benefits affects the result significantly by recycling important materials.Meanwhile,the main cause and relevant suggestion for improvement were traced respectively.Finally,the environmental impacts of various power generations were compared,and results show that the power route is of obvious advantage.Among the renewable energy,ORC system using Al_(2)O_(3)/R141b nanorefrigerant with minimal environmental impact is only 0.67%of coal-fired power generation.The environmental impact of current work is about 14.34%of other nations’PV results.展开更多
A comparison on subcritical and transcritical organic Rankine cycle（ORC） system with a heat source of 110 ℃ geothermal water was presented. The net power output, thermal and exergy efficiencies and the products of ...A comparison on subcritical and transcritical organic Rankine cycle（ORC） system with a heat source of 110 ℃ geothermal water was presented. The net power output, thermal and exergy efficiencies and the products of the heat transfer coefficient（U） and the total heat exchange area（A）（UA values） were calculated for parametric optimization. Nine candidate working fluids were investigated and compared. Under the given conditions, transcritical systems have higher net power outputs than subcritical ones. The highest net power output of transcritical systems is 18.63 k W obtained by R218, and that of subcritical systems is 13.57 k W obtained by R600 a. Moreover, with the increase of evaporating pressure, the thermal and exergy efficiencies of transcritical systems increase at first and then decrease, but the efficiencies of subcritical ones increase. As a result, the efficiencies of transcritical systems cannot always outperform those of the subcritical ones. However, the subcritical systems have lower minimum UA values and lower expansion ratios than the transcritical ones at the maximum net power output. In addition, the transcritical cycles have higher expansion ratios than the subcritical ones at their maximum net power output.展开更多
A dedicated heat exchanger model is introduced for the optimization of heavy-duty diesel engines.The model is a prerequisite for the execution of CFD simulations,which are used to improve waste heat recovery in these ...A dedicated heat exchanger model is introduced for the optimization of heavy-duty diesel engines.The model is a prerequisite for the execution of CFD simulations,which are used to improve waste heat recovery in these systems.Several optimization methods coupled with different types of working fluids are compared in terms of exergy efficiency and heat exchanger complicity.The three considered optimization methods all lead to significant improvements in the R245fa and R1233zd systems with a comparatively low evaporation temperature.The optimal R245fa system has the highest efficiency increase(77.49%).The cyclopentane system displays the highest efficiency among the optimized ORC(Organic Rankine Cycle)systems,yet achieved by using a much heavier evaporator HEC(Heat Exchanging Core).In contrast,the 96.84%efficiency increase for the optimized R1233zd is achieved with only 68.96%evaporator weight.展开更多
In order to improve the recovery and utilization rates of sinter waste heat effectively,the organic Rankine cycle(ORC)system with subcritical cycle was designed to recover the low-temperature sinter cooling flue gas w...In order to improve the recovery and utilization rates of sinter waste heat effectively,the organic Rankine cycle(ORC)system with subcritical cycle was designed to recover the low-temperature sinter cooling flue gas waste heat in an annular cooler for power generation.The thermodynamic,economic and multi-objective optimization models of ORC system were established,and R600a was selected as the ORC working medium.Subsequently,the variations in system thermodynamic performance and economic performance with the ORC thermal parameters were discussed in detail,and the optimal ORC thermal parameters were determined.The results show that the system net output power increases with increasing the evaporation temperature and decreasing the condensation temperature and increases first and then,decreases with the increase in superheat degree for a given flue gas outlet temperature in the evaporator,while the heat transfer area per unit net output power appears different variation trends in various ranges of flue gas outlet temperature.Taking the sinter cooling flue gas waste heat of 160℃as the ORC heat source,the optimal thermal parameters of ORC system were the flue gas outlet temperature of 90℃,the evaporation temperature of 95℃,the superheat degree of 10℃,and the condensation temperature of 28℃.展开更多
The use of renewable energy sources is attracting more and more attention with the global development.Solar thermochemical fuel production is a key approach of utilizing renewable energy,and the design of multi-genera...The use of renewable energy sources is attracting more and more attention with the global development.Solar thermochemical fuel production is a key approach of utilizing renewable energy,and the design of multi-generation systems using this method has emerged as an important research direction.Most of the currently proposed systems using thermochemical cycles rely on multi-step thermochemical cycles,which involve acidic substances that can corrode system pipelines and components,making them challenging to implement.Current studies focus on simulation investigations,lacking experimental validation with prototype models.Drawing from experimental results,this study proposes a novel multi-generation system using a two-step Ce-based solar thermochemical cycle,which avoids the production of acidic substances,achieves negative carbon emissions,and alleviates heat losses during reaction temperature swings.The proposed system demonstrates superior performance with energy and exergy efficiencies of 74.2%and 21.4%respectively.Furthermore,variable condition analysis results confirm the system’s ability to maintain near-peak efficiencies across a wide range of operating parameters,providing valuable insights for the practical application of thermochemical cycles in real-world systems and advancing the field of renewable energy utilization.展开更多
As mining activities expand deeper,deep high-temperature formations seriously threaten the future safe exploitation,while deep geothermal energy has great potential for development.Combining the formation cooling and ...As mining activities expand deeper,deep high-temperature formations seriously threaten the future safe exploitation,while deep geothermal energy has great potential for development.Combining the formation cooling and geothermal mining in mines to establish a thermos-hydraulic coupling numerical model for fractured formation.The study investigates the formation heat transfer behaviour,heat recovery performance and thermal economic benefits influenced during the life cycle.The results show that the accumulation of cold energy during the cold storage phase induces a decline in formation temperature.The heat recovery phase is determined by the extent of the initial cold domain,which contracts inward from the edge and decelerates the heat recovery rate gradually.With groundwater velocity increases,the thermal regulation efficiency gradually increases,the production temperature decreases,while the effective radius and thermal power increase first and then decrease.The injected volume and temperature significantly affect,with higher injection temperatures slowing thermal recovery,and the thermal regulation efficiency is more sensitive to changes in formation permeability and thermal conductivity.The heat extraction performance is positively correlated with all factors.The levelized cost of electricity is estimated at 0.1203$/(kW·h)during the cold storage.During the heat recovery,annual profit is primarily driven by cooling benefits.展开更多
As the energy crisis intensifies,the organic Rankine cycle(ORC)is increasingly employed for efficient recovery of low-temperature waste heat.The operation of the ORC system necessitates the use of numerous sensors to ...As the energy crisis intensifies,the organic Rankine cycle(ORC)is increasingly employed for efficient recovery of low-temperature waste heat.The operation of the ORC system necessitates the use of numerous sensors to monitor its status.Over time,these sensors may become faulty,rendering accurate and timely diagnosis is critical for proper and safe functioning of the ORC system.Currently,there is a lack of rapid diagnostic methods for sensor faults in ORC systems.This study establishes an ORC test bench utilizing cyclopentane as the working fluid.Experimental data incorporating induced faults from the ORC test bench is employed to train machine learning-based models for sensor fault diagnosis.The test results indicate that the diagnostic model developed in this study can accurately diagnose various sensor faults in the ORC system,thereby ensuring its safe operation.Notably,the method based on Bayesian-optimized long short-term memory network(BO-LSTM)achieved the highest diagnostic accuracy,reaching up to 95.92%.展开更多
The coupling effects among the flow field,temperature distribution and structural deformation in a turbine cannot be ignored,particularly during flight cycles when the turbine experiences varied operational states.Rel...The coupling effects among the flow field,temperature distribution and structural deformation in a turbine cannot be ignored,particularly during flight cycles when the turbine experiences varied operational states.Relying solely on steady-state solutions cannot predict the detrimental effects caused by hysteresis.Consequently,this paper employs a quasi-steady-state fluid-thermalstructure multidisciplinary coupling solution method,integrating transient solid heat conduction with steady-state flow field and static structural deformation solutions.After conducting a numerical simulation of a three-dimensional,five-stage,low-pressure turbine air system,the following conclusions are drawn:when boundary conditions attain high-power states through processes that are numerically identical but in opposite directions,slight variations in solid deformation significantly impact the flow field;when boundary conditions attain high-power states through processes that are directionally consistent but have different numerical values,the influence of the boundary condition change rate on the flow field surpasses that of solid deformation.In terms of turbine design parameters,a large difference in stage-reaction between adjacent stages at the lower radius of the turbine can lead to significant changes in the disc cavity flow field during flight cycles.The difference in the stage-reaction of 0.23 at 10%blade height in adjacent stages may induce severe gas ingress in the stator disc cavity.Thus,it is crucial to minimize this difference and to appropriately extend the duration of the deceleration phase to ensure the turbine's safe operation.展开更多
Lakes are carbon dioxide(CO_(2))and methane(CH_(4))emission hotspots,whose associated flux is spatially vari-able.Many studies have investigated the impact of microorganisms and environmental factors on CO_(2) and CH_...Lakes are carbon dioxide(CO_(2))and methane(CH_(4))emission hotspots,whose associated flux is spatially vari-able.Many studies have investigated the impact of microorganisms and environmental factors on CO_(2) and CH_(4) emissions between different lakes.However,the carbon emissions and their influencing factors of different areas within a single lake remain poorly understood.Accordingly,this study investigates CO_(2) and CH_(4) emission hetero-geneity in a large floodplain lake system and distribution characteristics of associated functional microorganisms.Findings show that mean CO_(2) and CH_(4) flux values in the sub lake area were 62.03±24.21 mg/(m2·day)and 5.97±3.2μg/(m2·day),which were greater by factors of 1.78 and 2.96 compared to the water channel and the main lake area,respectively.The alpha diversity of methanogens in the sub lake area was lower than that in the main lake and water channel areas.The abundance of methanogens in bottom water layer was higher compared with the middle and surface layers.Conversely,the abundance of methane(CH_(4))-oxidizing bacteria in the surface layer was higher than that in the bottom layer.Additionally,the composition of methanogen and CH_(4)-oxidizing bacterial community,chlorophyll a(Chl-a),pH,total phosphorus(TP)and dissolved organic carbon(DOC)con-tent constituted the dominate driving factors affecting lake C emissions.Results from this study can be used to improve our understanding of lake spatial heterogeneous of CO_(2) and CH_(4) emission and the driving mechanisms within floodplain lakes under the coupling effects of functional C microorganisms and environmental factors.展开更多
This study introduces superabsorbent polymers(SAP)into recycled concrete and,through freeze-thaw cycle tests,unconfined compressive strength tests,and nuclear magnetic resonance(NMR)analysis,evaluates the freeze-thaw ...This study introduces superabsorbent polymers(SAP)into recycled concrete and,through freeze-thaw cycle tests,unconfined compressive strength tests,and nuclear magnetic resonance(NMR)analysis,evaluates the freeze-thaw resistance and durability of recycled concrete samples under varying freeze-thaw cycles.The results indicate that an appropriate addition of SAP significantly enhances the freeze-thaw resistance of recycled concrete.After 200 freeze-thaw cycles,the RS0.6 sample retained good surface integrity,demonstrating the best performance.Compared to NAC,its mass loss decreased by 1.16%,the relative dynamic modulus improved by 7.01%,and the compressive strength loss rate decreased by 5.41%.Additionally,T2 spectrum analysis revealed that adding SAP optimized the pore structure of recycled concrete and mitigated pore development during freeze-thaw cycles.As the number of freeze-thaw cycles increased,the RS0.3 and RS0.6 samples demonstrated superior frost resistance compared to NAC.However,an excessive amount of SAP increased pore expansion during subsequent freeze-thaw cycles,ultimately weakening frost resistance.展开更多
Compared with traditional energy sources,wind power has a lower environmental impact.However,emissions are still generated across the life cycle of wind turbines,from production to recycling.As wind power rapidly deve...Compared with traditional energy sources,wind power has a lower environmental impact.However,emissions are still generated across the life cycle of wind turbines,from production to recycling.As wind power rapidly develops and deployment increases,these impacts are becoming increasingly evident.A comprehensive understanding of these impacts is crucial for sustainable development.Based on the harmonization of previous detailed life cycle assessment(LCA)studies,this study develops a simplified LCA model that estimates the life cycle environmental impacts of wind turbines based on their nominal power.Using this simplified LCA model,we assess the global warming potential(GWP),acidification potential(AP),and cumulative energy demand(CED)of wind power at the regional scale for 2022 and under three future scenarios(high-power wind turbine promotion,reduced wind curtailment,and a comprehensive development scenario).The results indicate that in 2022,the life cycle GWP,AP,and CED of wind power in western China were 10.76 g CO_(2) eq/kWh,0.177 g SO_(2) eq/kWh,and 17.6 kJ/kWh,respectively.Scenario simulations suggest that reducing wind curtailment is the most effective approach for reducing emissions in Inner Mongolia,Gansu,Qinghai,Ningxia,and Xinjiang,producing average decreases of 8.64%in GWP,8.39%in AP,and 9.26%in CED.In contrast,for Guangxi,Chongqing,Sichuan,Guizhou,Yunnan,Xizang,and Shaanxi,the promotion of high-power wind turbines provides greater environmental benefits than reducing curtailment,producing average decreases of 3.45%,3.09%,and 4.29%in GWP,AP,and CED,respectively.These findings help clarify the environmental impact of wind power across its life cycle at the regional scale and provide theoretical references for the direction of future wind power development and the formulation of related policies.展开更多
The solar cycle(SC),a phenomenon caused by the quasi-periodic regular activities in the Sun,occurs approximately every 11 years.Intense solar activity can disrupt the Earth’s ionosphere,affecting communication and na...The solar cycle(SC),a phenomenon caused by the quasi-periodic regular activities in the Sun,occurs approximately every 11 years.Intense solar activity can disrupt the Earth’s ionosphere,affecting communication and navigation systems.Consequently,accurately predicting the intensity of the SC holds great significance,but predicting the SC involves a long-term time series,and many existing time series forecasting methods have fallen short in terms of accuracy and efficiency.The Time-series Dense Encoder model is a deep learning solution tailored for long time series prediction.Based on a multi-layer perceptron structure,it outperforms the best previously existing models in accuracy,while being efficiently trainable on general datasets.We propose a method based on this model for SC forecasting.Using a trained model,we predict the test set from SC 19 to SC 25 with an average mean absolute percentage error of 32.02,root mean square error of 30.3,mean absolute error of 23.32,and R^(2)(coefficient of determination)of 0.76,outperforming other deep learning models in terms of accuracy and training efficiency on sunspot number datasets.Subsequently,we use it to predict the peaks of SC 25 and SC 26.For SC 25,the peak time has ended,but a stronger peak is predicted for SC 26,of 199.3,within a range of 170.8-221.9,projected to occur during April 2034.展开更多
The dust cycle is a crucial component of the present-day Martian climate system.This study examines its multitimescale variability using an optimized 50-year simulation with the fully interactive scheme from the Globa...The dust cycle is a crucial component of the present-day Martian climate system.This study examines its multitimescale variability using an optimized 50-year simulation with the fully interactive scheme from the Global Open Planetary Atmospheric Model for Mars(GoMars),a newly developed Mars General Circulation Model(MGCM).GoMars is able to reproduce the diurnal,seasonal,and interannual characteristics of the dust cycle in several key aspects,with high repeatability in diurnal and seasonal variations during non-global dust storm(non-GDS)years.The model’s“climatology”(non-GDS years ensemble mean)captures the seasonal pattern and magnitude of the vertical–meridional dust distribution,validated against Mars Climate Database and Mars Climate Sounder observations.In the absence of direct observations,the GoMars-simulated near-surface wind stress lifting flux is evaluated through comparisons with other MGCMs(e.g.,MarsWRF),revealing consistent seasonal and spatial patterns.As for the diurnal cycle,the peak dust devil lifting flux occurs at 1200–1300 local time,matching the Mars Pathfinder measurements.The model also successfully captures the intense dust devil activity in Amazonis,a region identified as a major dust devil hotspot based on observational data.In GDS years,GoMars effectively reproduces spontaneous GDSs,capturing their observed onset times,locations,and dust transport patterns as exhibited in specific Martian years.The model also simulates significant interannual variability,with irregular GDS intervals along with reasonable dust–atmosphere interactions.展开更多
The study of shortwave(SW) radiation and its interactions with our planet has proven critical for advancing the understanding of the Earth–atmosphere system. Here, the author shares an accessible and high-level persp...The study of shortwave(SW) radiation and its interactions with our planet has proven critical for advancing the understanding of the Earth–atmosphere system. Here, the author shares an accessible and high-level perspective on recent progress, surprises encountered, and promising future research directionsa. A brief context for the study of SW radiation is provided, after which three specific aspects are focused upon that the author considers particularly important. First, the significance of three-dimensional(3D) SW radiative effects is highlighted via impacts on surface downward SW radiation in complex cloud fields. Crucially, it is shown that probability distributions of surface radiation can only be reliably simulated when accounting for 3D effects, which has implications for various applications and next-generation atmospheric modeling. Second, the significance of the often overlooked diurnal cycle in global top-of-atmosphere upward SW radiation is underscored by quantifying the controlling properties and processes. Opportunities for improved future satellite observations of the global diurnal cycle are noted. Third, the wealth of information provided by the spectral dimension of SW radiation is demonstrated through the extraction and attribution of SW spectral signatures. It is argued that further exploration of the spectral dimension, aided by the recently launched and upcoming suite of spectrally resolved SW satellite observations, promises a new era of SW radiation research.展开更多
The airflow mechanics in adult nasal airways,whether healthy or abnormal,are extensively studied and investigated,but the flow mechanics in child nasal airways remain underexplored.This study investigates the airflow ...The airflow mechanics in adult nasal airways,whether healthy or abnormal,are extensively studied and investigated,but the flow mechanics in child nasal airways remain underexplored.This study investigates the airflow mechanics in the child’s nasal upper airway with adenoid hypertrophy,with an adenoid nasopharyngeal ratio(AN of 0.9),under cyclic inhalation and exhalation.An inlet respiratory cycle with three different flow rates(3.2 L/min calm breathing,8.6 L/min normal breathing,and 19.3 L/min intensive breathing)was simulated by using the computational fluid dynamics approach.To better capture the interaction between airflow and the flexible airway tissue,fluid-structure interaction analysis was performed at the normal breathing rate.Comparing the airflow dynamics during inhalation and exhalation,the pressure drops,nasal resistance,and wall shear stress show significant differences in the nasopharyngeal region for all different flow rates.This observation suggests that the inertial effect associated with the transient flow is important during exhalation and inhalation.Furthermore,the considerable temporal variation in flow rate distribution across a specific cross-section of the nasal airway highlights the critical role of transient data in virtual surgery planning and data for clinical decisions.展开更多
Hair loss,a multifactorial disorder characterized by follicular miniaturization and excessive shedding,significantly impairs psychological well-being and quality of life.Cyperus rotundus rhizome(CR),a traditional Chin...Hair loss,a multifactorial disorder characterized by follicular miniaturization and excessive shedding,significantly impairs psychological well-being and quality of life.Cyperus rotundus rhizome(CR),a traditional Chinese medicine used for various ailments,has not been evaluated for efficacy in treating hair loss.This study presents the first comprehensive assessment of the hair growth-promoting effects of ethanol extract from CR on mouse primary dermal papilla cells(MDPCs)and human immortalized hair DPCs(IHHDPCs),employing cell counting kit-8(CCK-8),scratch assay,reverse transcription-quantitative polymerase chain reaction(RT-q PCR),and Western blot(WB).CR treatment activated the Wnt/β-Catenin signaling pathway by upregulating Wnt10b,increasingβ-Catenin protein levels and promoting its nuclear translocation,while simultaneously downregulating transforming growth factor-beta 1(TGF-β1),BMP4,and dickkopf-related protein 1(DKK1)in MDPCs.These molecular changes enhanced cell proliferation and increased secretion of key growth factors—insulin-like growth factor 1(IGF1),keratinocyte growth factor(KGF),and vascular endothelial growth factor(VEGF)—thereby stimulating hair growth and prolonging the anagen phase,which was confirmed in an ex vivo hair follicle(HF)organ culture model.Chromatographic analysis identified the petroleum ether fraction(CRP),enriched in sesquiterpenes,as the primary bioactive component.Both CR and CRP promoted IHHDPC proliferation,migration,and growth factor expression through activation of the Wnt/β-Catenin pathway,with CRP exhibiting superior bioactivity.Furthermore,both treatments stimulated HF cycling,increased follicular density,and upregulated Ki67 andβ-Catenin expression in the dorsal skin of C57BL/6 mice.Collectively,these findings demonstrate that CR and CRP promote hair growth and modulate the hair cycle via enhancement of Wnt/β-Catenin signaling,providing a scientific basis for the potential clinical application of C.rotundus rhizomes in hair loss therapy and the development of related pharmaceuticals or cosmetics.展开更多
The conversion of CO_(2) into high value added chemicals via the Fischer-Tropsch synthesis(FTS)reaction has attracted significant attention.The surface oxygenation environment is a significant factor influencing the p...The conversion of CO_(2) into high value added chemicals via the Fischer-Tropsch synthesis(FTS)reaction has attracted significant attention.The surface oxygenation environment is a significant factor influencing the performance of the catalyst.In this work,spin-polarized density-functional theory calculations have been used to investigate the adsorption and reactions of CO_(2) and H to generate CH4 and CH3OH on Fe_(5)C_(2)(100)surfaces with varying OH∗coverage.On the pure Fe_(5)C_(2)(100)surface,surface C^(∗) preferentially reacts with hydrogen to form CH4,exposing C^(∗) vacancy.CO_(2) favors adsorbing on the C^(∗) vacancy to further dissociating and activating.The co-adsorption of OH∗promotes the C^(∗) cycle process by facilitating the hydrogenation of C^(∗).The Fe_(5)C_(2) surface with an oxide interface is favorable for reducing FexOy,thereby maintaining the dynamic stability of the surface.Therefore,surface oxidation is inevitably involved in the entire C^(∗) cycle of the FTS reaction and regulates the relative content of iron oxides and iron carbides.Our work can contribute to the rational modulation of the surface C^(∗) cycle,thereby enhancing catalyst performance.展开更多
基金supported by the National Science and Technology Major Project(No.2011ZX05061).
文摘At present,the aeration-assisted cutting-carrying technology is faced with complexities in the drilling of CBM multi-branch horizontal wells.For example,the aerating pressure is hardly maintained,and the borehole instability may happen.In view of these prominent problems,the technology of double casing tubes&a binary cycle system suitable for CBM multi-branch horizontal wells was developed according to the Venturi principle by means of parasitic tube insufflation which is used for well control simulation system.Then,a multiphase flow finite element model was established for the fluid-cutting particle system in this drilling condition.This technology was tested in field.Double-casing tubes cementing is adopted in this technology and a jet generator is installed at the bottom of the inner casing.In the process of drilling,the drilling fluid injected through double intermediate casing annulus is converted by the jet generator into a high-efficiency steering water jet,which,together with the water jet generated by the bit nozzle,increases the fluid returning rate in the inner annulus space.It is indicated from simulation results that the cutting-carrying effect is the best when the included angle between the nozzle of the jet generator and the vertical direction is 30°.Besides,the influential laws of cutting size,primary cycle volume,accessory cycle volume and drilling velocity on hole cleaning are figured out.It is concluded that this technology increases the flow rate of drilling fluid in annulus space,the returning rate of drilling fluid significantly and the cutting-carrying capacity.It is currently one of the effective hole cleaning technologies for CBM multi-branch horizontal wells where fresh water is taken as the drilling fluid.
基金supported by the National Natural Science Foundation of China(61233004,61221003,61374109,61473184,61703223,61703238)the National Basic Research Program of China(973 Program)(2013CB035500)+1 种基金Shandong Provincial Natural Science Foundation of China(ZR2017BF014,ZR2017MF017)the National Research Foundation of Singapore(NRF-2011,NRF-CRP001-090)
文摘Abstract--Vapor compression refrigeration cycle （VCC） system is a high dimensional coupling thermodynamic system for which the controller design is a great challenge. In this paper, a model predictive control based energy efficient control strategy which aims at maximizing the system efficiency is proposed. Firstly, according to the mass and energy conservation law, an analysis on the nonlinear relationship between superheat and cooling load is carried out, which can produce the maximal effect on the system performance. Then a model predictive control （MPC） based controller is developed for tracking the calculated setting curve of superheat degree and pressure difference based on model identified from data which can be obtained from an experimental rig. The proposed control strategy maximizes the coefficient of performance （COP） which depends on operating conditions, in the meantime, it meets the changing demands of cooling capacity. The effectiveness of the control performance is validated on the experimental rig. Index Terms--Cooling load, model predictive control （MPC）, superheat, vapor compression refrigeration cycle （VCC）.
基金supported by the Key Technologies R&D program of Tianjin,China (16YFZCGX00090)
文摘According to the problem that the selection of traditional PID control parameters is too complicated in evaporator of Organic Rankine Cycle system(ORC),an evaporator PID controller based on BP neural netw ork optimization is designed. Based on the control theory,the model of ORC evaporator is set up. The BP algorithm is used to control the Kp,Kiand Kdparameters of the evaporator PID controller,so that the evaporator temperature can reach the optimal state quickly and steadily. The M ATLAB softw are is used to simulate the traditional PID controller and the BP neural netw ork PID controller. The experimental results show that the Kp,Kiand Kdparameters of the BP neural netw ork PID controller are 0. 5677,0. 2970,and 0. 1353,respectively.Therefore,the evaporator PID controller based on BP neural netw ork optimization not only satisfies the requirements of the system performance,but also has better control parameters than the traditional PID controller.
基金Fund Project in 2020,China(No.KKZ3202052058)and the support of Scientific Research Fund from Yunnan Education Department in China(No.2022J0064).
文摘The use of nanorefrigerants in Organic Rankine Cycle(ORC)units is believed to affect the cycle environment performance,but backed with very few relevant studies.For this purpose,a life cycle assessment(LCA)has been performed for the ORC system using nanorefrigerant,the material and energy input,characteristic indicators and comprehensive index of environmental impact,total energy consumption and energy payback time(BPBT)of the whole life cycle of ORC system using Al_(2)O_(3)/R141b nanorefrigerant were calculated.Total environmental comprehensive indexes reveal that ECER-135 index decrease by 1.5%after adding 0.2%Al_(2)O_(3)nanoparticles to R141b.Based on the contribution analysis and sensitivity analysis,it can be found out ORC system manufacturing is of the most critical stage,where,the ECER-135 index of ORC component production is the greatest,followed by the preparation process of R141b,transportation phase,and that of Al_(2)O_(3)nanoparticles preparation is small.The retirement phase which has good environmental benefits affects the result significantly by recycling important materials.Meanwhile,the main cause and relevant suggestion for improvement were traced respectively.Finally,the environmental impacts of various power generations were compared,and results show that the power route is of obvious advantage.Among the renewable energy,ORC system using Al_(2)O_(3)/R141b nanorefrigerant with minimal environmental impact is only 0.67%of coal-fired power generation.The environmental impact of current work is about 14.34%of other nations’PV results.
基金Project(2012AA053001) supported by the National High Technology Research and Development Program of China
文摘A comparison on subcritical and transcritical organic Rankine cycle（ORC） system with a heat source of 110 ℃ geothermal water was presented. The net power output, thermal and exergy efficiencies and the products of the heat transfer coefficient（U） and the total heat exchange area（A）（UA values） were calculated for parametric optimization. Nine candidate working fluids were investigated and compared. Under the given conditions, transcritical systems have higher net power outputs than subcritical ones. The highest net power output of transcritical systems is 18.63 k W obtained by R218, and that of subcritical systems is 13.57 k W obtained by R600 a. Moreover, with the increase of evaporating pressure, the thermal and exergy efficiencies of transcritical systems increase at first and then decrease, but the efficiencies of subcritical ones increase. As a result, the efficiencies of transcritical systems cannot always outperform those of the subcritical ones. However, the subcritical systems have lower minimum UA values and lower expansion ratios than the transcritical ones at the maximum net power output. In addition, the transcritical cycles have higher expansion ratios than the subcritical ones at their maximum net power output.
基金funded by National Engineering Laboratory for Mobile Source Emission Control Technology of China[Grant No.NELMS2019A01]the Undergraduate School of Shandong University,China[Grant No.2022Y155].
文摘A dedicated heat exchanger model is introduced for the optimization of heavy-duty diesel engines.The model is a prerequisite for the execution of CFD simulations,which are used to improve waste heat recovery in these systems.Several optimization methods coupled with different types of working fluids are compared in terms of exergy efficiency and heat exchanger complicity.The three considered optimization methods all lead to significant improvements in the R245fa and R1233zd systems with a comparatively low evaporation temperature.The optimal R245fa system has the highest efficiency increase(77.49%).The cyclopentane system displays the highest efficiency among the optimized ORC(Organic Rankine Cycle)systems,yet achieved by using a much heavier evaporator HEC(Heat Exchanging Core).In contrast,the 96.84%efficiency increase for the optimized R1233zd is achieved with only 68.96%evaporator weight.
基金support for this work provided by the National Natural Science Foundation of China(51974087 and 51904074)Anhui Provincial Natural Science Foundation(1908085QE203)+1 种基金Natural Science Research Foundation of Anhui Province University(2022AH050262)Science Research Foundation of Anhui Jianzhu University(2020QDZ02).
文摘In order to improve the recovery and utilization rates of sinter waste heat effectively,the organic Rankine cycle(ORC)system with subcritical cycle was designed to recover the low-temperature sinter cooling flue gas waste heat in an annular cooler for power generation.The thermodynamic,economic and multi-objective optimization models of ORC system were established,and R600a was selected as the ORC working medium.Subsequently,the variations in system thermodynamic performance and economic performance with the ORC thermal parameters were discussed in detail,and the optimal ORC thermal parameters were determined.The results show that the system net output power increases with increasing the evaporation temperature and decreasing the condensation temperature and increases first and then,decreases with the increase in superheat degree for a given flue gas outlet temperature in the evaporator,while the heat transfer area per unit net output power appears different variation trends in various ranges of flue gas outlet temperature.Taking the sinter cooling flue gas waste heat of 160℃as the ORC heat source,the optimal thermal parameters of ORC system were the flue gas outlet temperature of 90℃,the evaporation temperature of 95℃,the superheat degree of 10℃,and the condensation temperature of 28℃.
基金support provided by the Distinguish Young Scholars of the National Natural Science Foundation of China(No.52225601)the Major Program of the National Natural Science Foundation of China(No.52090061).
文摘The use of renewable energy sources is attracting more and more attention with the global development.Solar thermochemical fuel production is a key approach of utilizing renewable energy,and the design of multi-generation systems using this method has emerged as an important research direction.Most of the currently proposed systems using thermochemical cycles rely on multi-step thermochemical cycles,which involve acidic substances that can corrode system pipelines and components,making them challenging to implement.Current studies focus on simulation investigations,lacking experimental validation with prototype models.Drawing from experimental results,this study proposes a novel multi-generation system using a two-step Ce-based solar thermochemical cycle,which avoids the production of acidic substances,achieves negative carbon emissions,and alleviates heat losses during reaction temperature swings.The proposed system demonstrates superior performance with energy and exergy efficiencies of 74.2%and 21.4%respectively.Furthermore,variable condition analysis results confirm the system’s ability to maintain near-peak efficiencies across a wide range of operating parameters,providing valuable insights for the practical application of thermochemical cycles in real-world systems and advancing the field of renewable energy utilization.
基金financial support from the National Natural Science Foundation of China(Nos.52434006,52374151,and 51927808)。
文摘As mining activities expand deeper,deep high-temperature formations seriously threaten the future safe exploitation,while deep geothermal energy has great potential for development.Combining the formation cooling and geothermal mining in mines to establish a thermos-hydraulic coupling numerical model for fractured formation.The study investigates the formation heat transfer behaviour,heat recovery performance and thermal economic benefits influenced during the life cycle.The results show that the accumulation of cold energy during the cold storage phase induces a decline in formation temperature.The heat recovery phase is determined by the extent of the initial cold domain,which contracts inward from the edge and decelerates the heat recovery rate gradually.With groundwater velocity increases,the thermal regulation efficiency gradually increases,the production temperature decreases,while the effective radius and thermal power increase first and then decrease.The injected volume and temperature significantly affect,with higher injection temperatures slowing thermal recovery,and the thermal regulation efficiency is more sensitive to changes in formation permeability and thermal conductivity.The heat extraction performance is positively correlated with all factors.The levelized cost of electricity is estimated at 0.1203$/(kW·h)during the cold storage.During the heat recovery,annual profit is primarily driven by cooling benefits.
基金supported by the National Key R&D Program of China(2024YFE0213200)supported by the Tianjin Municipal Science and Technology Bureau(23jCjQjC00260).
文摘As the energy crisis intensifies,the organic Rankine cycle(ORC)is increasingly employed for efficient recovery of low-temperature waste heat.The operation of the ORC system necessitates the use of numerous sensors to monitor its status.Over time,these sensors may become faulty,rendering accurate and timely diagnosis is critical for proper and safe functioning of the ORC system.Currently,there is a lack of rapid diagnostic methods for sensor faults in ORC systems.This study establishes an ORC test bench utilizing cyclopentane as the working fluid.Experimental data incorporating induced faults from the ORC test bench is employed to train machine learning-based models for sensor fault diagnosis.The test results indicate that the diagnostic model developed in this study can accurately diagnose various sensor faults in the ORC system,thereby ensuring its safe operation.Notably,the method based on Bayesian-optimized long short-term memory network(BO-LSTM)achieved the highest diagnostic accuracy,reaching up to 95.92%.
基金supported by the National Science and Tech-nology Major Project,China(No.J2019-II-0012-0032)。
文摘The coupling effects among the flow field,temperature distribution and structural deformation in a turbine cannot be ignored,particularly during flight cycles when the turbine experiences varied operational states.Relying solely on steady-state solutions cannot predict the detrimental effects caused by hysteresis.Consequently,this paper employs a quasi-steady-state fluid-thermalstructure multidisciplinary coupling solution method,integrating transient solid heat conduction with steady-state flow field and static structural deformation solutions.After conducting a numerical simulation of a three-dimensional,five-stage,low-pressure turbine air system,the following conclusions are drawn:when boundary conditions attain high-power states through processes that are numerically identical but in opposite directions,slight variations in solid deformation significantly impact the flow field;when boundary conditions attain high-power states through processes that are directionally consistent but have different numerical values,the influence of the boundary condition change rate on the flow field surpasses that of solid deformation.In terms of turbine design parameters,a large difference in stage-reaction between adjacent stages at the lower radius of the turbine can lead to significant changes in the disc cavity flow field during flight cycles.The difference in the stage-reaction of 0.23 at 10%blade height in adjacent stages may induce severe gas ingress in the stator disc cavity.Thus,it is crucial to minimize this difference and to appropriately extend the duration of the deceleration phase to ensure the turbine's safe operation.
基金supported by the National Natural Science Foundation of China(No.42225103).
文摘Lakes are carbon dioxide(CO_(2))and methane(CH_(4))emission hotspots,whose associated flux is spatially vari-able.Many studies have investigated the impact of microorganisms and environmental factors on CO_(2) and CH_(4) emissions between different lakes.However,the carbon emissions and their influencing factors of different areas within a single lake remain poorly understood.Accordingly,this study investigates CO_(2) and CH_(4) emission hetero-geneity in a large floodplain lake system and distribution characteristics of associated functional microorganisms.Findings show that mean CO_(2) and CH_(4) flux values in the sub lake area were 62.03±24.21 mg/(m2·day)and 5.97±3.2μg/(m2·day),which were greater by factors of 1.78 and 2.96 compared to the water channel and the main lake area,respectively.The alpha diversity of methanogens in the sub lake area was lower than that in the main lake and water channel areas.The abundance of methanogens in bottom water layer was higher compared with the middle and surface layers.Conversely,the abundance of methane(CH_(4))-oxidizing bacteria in the surface layer was higher than that in the bottom layer.Additionally,the composition of methanogen and CH_(4)-oxidizing bacterial community,chlorophyll a(Chl-a),pH,total phosphorus(TP)and dissolved organic carbon(DOC)con-tent constituted the dominate driving factors affecting lake C emissions.Results from this study can be used to improve our understanding of lake spatial heterogeneous of CO_(2) and CH_(4) emission and the driving mechanisms within floodplain lakes under the coupling effects of functional C microorganisms and environmental factors.
基金Funded by the Science and Technology Program of Gansu Province(Nos.25JRRA497,23ZDFA017)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB0950000)High-level Talent Funding of Kashi。
文摘This study introduces superabsorbent polymers(SAP)into recycled concrete and,through freeze-thaw cycle tests,unconfined compressive strength tests,and nuclear magnetic resonance(NMR)analysis,evaluates the freeze-thaw resistance and durability of recycled concrete samples under varying freeze-thaw cycles.The results indicate that an appropriate addition of SAP significantly enhances the freeze-thaw resistance of recycled concrete.After 200 freeze-thaw cycles,the RS0.6 sample retained good surface integrity,demonstrating the best performance.Compared to NAC,its mass loss decreased by 1.16%,the relative dynamic modulus improved by 7.01%,and the compressive strength loss rate decreased by 5.41%.Additionally,T2 spectrum analysis revealed that adding SAP optimized the pore structure of recycled concrete and mitigated pore development during freeze-thaw cycles.As the number of freeze-thaw cycles increased,the RS0.3 and RS0.6 samples demonstrated superior frost resistance compared to NAC.However,an excessive amount of SAP increased pore expansion during subsequent freeze-thaw cycles,ultimately weakening frost resistance.
基金supported by the National Key Research and Development Program of China(Grant No.2022YFF1303405).
文摘Compared with traditional energy sources,wind power has a lower environmental impact.However,emissions are still generated across the life cycle of wind turbines,from production to recycling.As wind power rapidly develops and deployment increases,these impacts are becoming increasingly evident.A comprehensive understanding of these impacts is crucial for sustainable development.Based on the harmonization of previous detailed life cycle assessment(LCA)studies,this study develops a simplified LCA model that estimates the life cycle environmental impacts of wind turbines based on their nominal power.Using this simplified LCA model,we assess the global warming potential(GWP),acidification potential(AP),and cumulative energy demand(CED)of wind power at the regional scale for 2022 and under three future scenarios(high-power wind turbine promotion,reduced wind curtailment,and a comprehensive development scenario).The results indicate that in 2022,the life cycle GWP,AP,and CED of wind power in western China were 10.76 g CO_(2) eq/kWh,0.177 g SO_(2) eq/kWh,and 17.6 kJ/kWh,respectively.Scenario simulations suggest that reducing wind curtailment is the most effective approach for reducing emissions in Inner Mongolia,Gansu,Qinghai,Ningxia,and Xinjiang,producing average decreases of 8.64%in GWP,8.39%in AP,and 9.26%in CED.In contrast,for Guangxi,Chongqing,Sichuan,Guizhou,Yunnan,Xizang,and Shaanxi,the promotion of high-power wind turbines provides greater environmental benefits than reducing curtailment,producing average decreases of 3.45%,3.09%,and 4.29%in GWP,AP,and CED,respectively.These findings help clarify the environmental impact of wind power across its life cycle at the regional scale and provide theoretical references for the direction of future wind power development and the formulation of related policies.
基金supported by the Academic Research Projects of Beijing Union University(ZK20202204)the National Natural Science Foundation of China(12250005,12073040,12273059,11973056,12003051,11573037,12073041,11427901,11572005,11611530679 and 12473052)+1 种基金the Strategic Priority Research Program of the China Academy of Sciences(XDB0560000,XDA15052200,XDB09040200,XDA15010700,XDB0560301,and XDA15320102)the Chinese Meridian Project(CMP).
文摘The solar cycle(SC),a phenomenon caused by the quasi-periodic regular activities in the Sun,occurs approximately every 11 years.Intense solar activity can disrupt the Earth’s ionosphere,affecting communication and navigation systems.Consequently,accurately predicting the intensity of the SC holds great significance,but predicting the SC involves a long-term time series,and many existing time series forecasting methods have fallen short in terms of accuracy and efficiency.The Time-series Dense Encoder model is a deep learning solution tailored for long time series prediction.Based on a multi-layer perceptron structure,it outperforms the best previously existing models in accuracy,while being efficiently trainable on general datasets.We propose a method based on this model for SC forecasting.Using a trained model,we predict the test set from SC 19 to SC 25 with an average mean absolute percentage error of 32.02,root mean square error of 30.3,mean absolute error of 23.32,and R^(2)(coefficient of determination)of 0.76,outperforming other deep learning models in terms of accuracy and training efficiency on sunspot number datasets.Subsequently,we use it to predict the peaks of SC 25 and SC 26.For SC 25,the peak time has ended,but a stronger peak is predicted for SC 26,of 199.3,within a range of 170.8-221.9,projected to occur during April 2034.
基金jointly supported by the National Natural Science Foundation of China(Grant No.42475135)the Key Technology Research Project of TW-3(TW3006)the IAP’s basic scientific research project during the 14th Five-Year Plan Period.
文摘The dust cycle is a crucial component of the present-day Martian climate system.This study examines its multitimescale variability using an optimized 50-year simulation with the fully interactive scheme from the Global Open Planetary Atmospheric Model for Mars(GoMars),a newly developed Mars General Circulation Model(MGCM).GoMars is able to reproduce the diurnal,seasonal,and interannual characteristics of the dust cycle in several key aspects,with high repeatability in diurnal and seasonal variations during non-global dust storm(non-GDS)years.The model’s“climatology”(non-GDS years ensemble mean)captures the seasonal pattern and magnitude of the vertical–meridional dust distribution,validated against Mars Climate Database and Mars Climate Sounder observations.In the absence of direct observations,the GoMars-simulated near-surface wind stress lifting flux is evaluated through comparisons with other MGCMs(e.g.,MarsWRF),revealing consistent seasonal and spatial patterns.As for the diurnal cycle,the peak dust devil lifting flux occurs at 1200–1300 local time,matching the Mars Pathfinder measurements.The model also successfully captures the intense dust devil activity in Amazonis,a region identified as a major dust devil hotspot based on observational data.In GDS years,GoMars effectively reproduces spontaneous GDSs,capturing their observed onset times,locations,and dust transport patterns as exhibited in specific Martian years.The model also simulates significant interannual variability,with irregular GDS intervals along with reasonable dust–atmosphere interactions.
基金the NOAA Atmospheric Science for Renewable Energy (ASRE) programthe Earth Venture Continuity 1 (EVC-1) Libera project under NASA Contract 80LARC20D0006the NOAA cooperative agreement with CIRES,NA22OAR4320151。
文摘The study of shortwave(SW) radiation and its interactions with our planet has proven critical for advancing the understanding of the Earth–atmosphere system. Here, the author shares an accessible and high-level perspective on recent progress, surprises encountered, and promising future research directionsa. A brief context for the study of SW radiation is provided, after which three specific aspects are focused upon that the author considers particularly important. First, the significance of three-dimensional(3D) SW radiative effects is highlighted via impacts on surface downward SW radiation in complex cloud fields. Crucially, it is shown that probability distributions of surface radiation can only be reliably simulated when accounting for 3D effects, which has implications for various applications and next-generation atmospheric modeling. Second, the significance of the often overlooked diurnal cycle in global top-of-atmosphere upward SW radiation is underscored by quantifying the controlling properties and processes. Opportunities for improved future satellite observations of the global diurnal cycle are noted. Third, the wealth of information provided by the spectral dimension of SW radiation is demonstrated through the extraction and attribution of SW spectral signatures. It is argued that further exploration of the spectral dimension, aided by the recently launched and upcoming suite of spectrally resolved SW satellite observations, promises a new era of SW radiation research.
基金supported by the National Key Research and Development Program of China(Grant No.2022YFF0707601).
文摘The airflow mechanics in adult nasal airways,whether healthy or abnormal,are extensively studied and investigated,but the flow mechanics in child nasal airways remain underexplored.This study investigates the airflow mechanics in the child’s nasal upper airway with adenoid hypertrophy,with an adenoid nasopharyngeal ratio(AN of 0.9),under cyclic inhalation and exhalation.An inlet respiratory cycle with three different flow rates(3.2 L/min calm breathing,8.6 L/min normal breathing,and 19.3 L/min intensive breathing)was simulated by using the computational fluid dynamics approach.To better capture the interaction between airflow and the flexible airway tissue,fluid-structure interaction analysis was performed at the normal breathing rate.Comparing the airflow dynamics during inhalation and exhalation,the pressure drops,nasal resistance,and wall shear stress show significant differences in the nasopharyngeal region for all different flow rates.This observation suggests that the inertial effect associated with the transient flow is important during exhalation and inhalation.Furthermore,the considerable temporal variation in flow rate distribution across a specific cross-section of the nasal airway highlights the critical role of transient data in virtual surgery planning and data for clinical decisions.
基金supported by the Start-up Fund of China Pharmaceutical University(No.3150020057)。
文摘Hair loss,a multifactorial disorder characterized by follicular miniaturization and excessive shedding,significantly impairs psychological well-being and quality of life.Cyperus rotundus rhizome(CR),a traditional Chinese medicine used for various ailments,has not been evaluated for efficacy in treating hair loss.This study presents the first comprehensive assessment of the hair growth-promoting effects of ethanol extract from CR on mouse primary dermal papilla cells(MDPCs)and human immortalized hair DPCs(IHHDPCs),employing cell counting kit-8(CCK-8),scratch assay,reverse transcription-quantitative polymerase chain reaction(RT-q PCR),and Western blot(WB).CR treatment activated the Wnt/β-Catenin signaling pathway by upregulating Wnt10b,increasingβ-Catenin protein levels and promoting its nuclear translocation,while simultaneously downregulating transforming growth factor-beta 1(TGF-β1),BMP4,and dickkopf-related protein 1(DKK1)in MDPCs.These molecular changes enhanced cell proliferation and increased secretion of key growth factors—insulin-like growth factor 1(IGF1),keratinocyte growth factor(KGF),and vascular endothelial growth factor(VEGF)—thereby stimulating hair growth and prolonging the anagen phase,which was confirmed in an ex vivo hair follicle(HF)organ culture model.Chromatographic analysis identified the petroleum ether fraction(CRP),enriched in sesquiterpenes,as the primary bioactive component.Both CR and CRP promoted IHHDPC proliferation,migration,and growth factor expression through activation of the Wnt/β-Catenin pathway,with CRP exhibiting superior bioactivity.Furthermore,both treatments stimulated HF cycling,increased follicular density,and upregulated Ki67 andβ-Catenin expression in the dorsal skin of C57BL/6 mice.Collectively,these findings demonstrate that CR and CRP promote hair growth and modulate the hair cycle via enhancement of Wnt/β-Catenin signaling,providing a scientific basis for the potential clinical application of C.rotundus rhizomes in hair loss therapy and the development of related pharmaceuticals or cosmetics.
基金the National Natural Science Foundation of China(22002008,22202226,22468042)Ningxia Key Research and Development Project(2022BEE03002,2022 BSB03056)+1 种基金the Fourth Batch of Ningxia Youth Talents Supporting Program(TJGC2019022)West Light Foundation of the Chinese Academy of Sciences(XAB2019AW02).
文摘The conversion of CO_(2) into high value added chemicals via the Fischer-Tropsch synthesis(FTS)reaction has attracted significant attention.The surface oxygenation environment is a significant factor influencing the performance of the catalyst.In this work,spin-polarized density-functional theory calculations have been used to investigate the adsorption and reactions of CO_(2) and H to generate CH4 and CH3OH on Fe_(5)C_(2)(100)surfaces with varying OH∗coverage.On the pure Fe_(5)C_(2)(100)surface,surface C^(∗) preferentially reacts with hydrogen to form CH4,exposing C^(∗) vacancy.CO_(2) favors adsorbing on the C^(∗) vacancy to further dissociating and activating.The co-adsorption of OH∗promotes the C^(∗) cycle process by facilitating the hydrogenation of C^(∗).The Fe_(5)C_(2) surface with an oxide interface is favorable for reducing FexOy,thereby maintaining the dynamic stability of the surface.Therefore,surface oxidation is inevitably involved in the entire C^(∗) cycle of the FTS reaction and regulates the relative content of iron oxides and iron carbides.Our work can contribute to the rational modulation of the surface C^(∗) cycle,thereby enhancing catalyst performance.
