The change-point hazards model has received much attention, since it can not only display the impacts of treatments or medical breakthroughs more directly, but also provide the time point when those impacts occur. In ...The change-point hazards model has received much attention, since it can not only display the impacts of treatments or medical breakthroughs more directly, but also provide the time point when those impacts occur. In this paper, we propose the single change-point hazards model for current status survival data with long-term survivors and investigate the estimation for the proposed model. Large-sample properties of the estimators are established. Simulation studies are carried out to evaluate the finite-sample performance of the estimation.展开更多
The paper discusses the regression analysis of current status data,which is common in various fields such as tumorigenic research and demographic studies.Analyzing this type of data poses a significant challenge and h...The paper discusses the regression analysis of current status data,which is common in various fields such as tumorigenic research and demographic studies.Analyzing this type of data poses a significant challenge and has recently gained considerable interest.Furthermore,the authors consider an even more difficult scenario where,apart from censoring,one also faces left-truncation and informative censoring,meaning that there is a potential correlation between the examination time and the failure time of interest.The authors propose a sieve maximum likelihood estimation(MLE)method and in the proposed method for inference,a copula-based procedure is applied to depict the informative censoring.Additionally,the authors utilise the splines to estimate the unknown nonparametric functions in the model,and the asymptotic properties of the proposed estimator are established.The simulation results indicate that the developed approach is effective in practice,and it has been successfully applied to a set of real data.展开更多
Misclassified current status data arises if each study subject can only be observed once and the observation status is determined by a diagnostic test with imperfect sensitivity and specificity.For the situation,anoth...Misclassified current status data arises if each study subject can only be observed once and the observation status is determined by a diagnostic test with imperfect sensitivity and specificity.For the situation,another issue that may occur is that the observation time may be correlated with the interested failure time,which is often referred to as informative censoring or observation times.It is well-known that in the presence of informative censoring,the analysis that ignores it could yield biased or even misleading results.In this paper,the authors consider such data and propose a frailty-based inference procedure.In particular,an EM algorithm based on Poisson latent variables is developed and the asymptotic properties of the resulting estimators are established.The numerical results show that the proposed method works well in practice and an application to a set of real data is provided.展开更多
This paper discusses efficient estimation for the additive hazards regression model when only bivariate current status data are available. Current status data occur in many fields including demographical studies and t...This paper discusses efficient estimation for the additive hazards regression model when only bivariate current status data are available. Current status data occur in many fields including demographical studies and tumorigenicity experiments （Keiding, 1991; Sun, 2006） and several approaches have been proposed for the additive hazards model with univariate current status data （Linet M., 1998; Martinussen and Scheike, 2002）. For bivariate data, in addition to facing the same problems as those with univariate data, one needs to deal with the association or correlation between two related failure time variables of interest. For this, we employ the copula model and an efficient estimation procedure is developed for inference. Simulation studies are performed to evaluate the proposed estimates and suggest that the approach works well in practical situations. An illustrative example is provided.展开更多
This article considers a semiparametric varying-coefficient partially linear regression model with current status data. The semiparametric varying-coefficient partially linear regression model which is a generalizatio...This article considers a semiparametric varying-coefficient partially linear regression model with current status data. The semiparametric varying-coefficient partially linear regression model which is a generalization of the partially linear regression model and varying-coefficient regression model that allows one to explore the possibly nonlinear effect of a certain covariate on the response variable. A Sieve maximum likelihood estimation method is proposed and the asymptotic properties of the proposed estimators are discussed. Under some mild conditions, the estimators are shown to be strongly consistent. The convergence rate of the estimator for the unknown smooth function is obtained and the estimator for the unknown parameter is shown to be asymptotically efficient and normally distributed. Simulation studies are conducted to examine the small-sample properties of the proposed estimates and a real dataset is used to illustrate our approach.展开更多
Current status data often arise in survival analysis and reliability studies, when a continuous response is reduced to an indicator of whether the response is greater or less than an observed random threshold value. T...Current status data often arise in survival analysis and reliability studies, when a continuous response is reduced to an indicator of whether the response is greater or less than an observed random threshold value. This article considers a partial linear model with current status data. A sieve least squares estimator is proposed to estimate both the regression parameters and the nonparametric function. This paper shows, under some mild condition, that the estimators are strong consistent. Moreover, the parameter estimators are normally distributed, while the nonparametric component achieves the optimal convergence rate. Simulation studies are carried out to investigate the performance of the proposed estimates. For illustration purposes, the method is applied to a real dataset from a study of the calcification of the hydrogel intraocular lenses, a complication of cataract treatment.展开更多
Regression analysis of interval-censored failure time data has recently attracted a great deal of attention partly due to their increasing occurrences in many fields.In this paper,we discuss a type of such data,multiv...Regression analysis of interval-censored failure time data has recently attracted a great deal of attention partly due to their increasing occurrences in many fields.In this paper,we discuss a type of such data,multivariate current status data,where in addition to the complex interval data structure,one also faces dependent or informative censoring.For inference,a sieve maximum likelihood estimation procedure is developed and the proposed estimators of regression parameters are shown to be asymptotically consistent and efficient.For the implementation of the method,an EM algorithm is provided,and the results from an extensive simulation study demonstrate the validity and good performance of the proposed inference procedure.For an illustration,the proposed approach is applied to a tumorigenicity experiment.展开更多
Success-failure life tests are widely used in reliability engineering research to evaluate the storage life of products, where the observed data are the current status data, usually summarized as the form of ＂binomia...Success-failure life tests are widely used in reliability engineering research to evaluate the storage life of products, where the observed data are the current status data, usually summarized as the form of ＂binomial life data＂. For this type of data, this paper proposes a two-stage algorithm to estimate some commonly used lifetime distributions. This Mgorithm is automatic, intuitively appealing and simple to implement. Simulation studies show that compared with some existing methods, the proposed algorithm is more stable and efficient, especially in small sample situations, and it can also be extended to deM with some complicated lifetime distributions.展开更多
基金the National Natural Sciences Foundation of China(Grant No.11471065).
文摘The change-point hazards model has received much attention, since it can not only display the impacts of treatments or medical breakthroughs more directly, but also provide the time point when those impacts occur. In this paper, we propose the single change-point hazards model for current status survival data with long-term survivors and investigate the estimation for the proposed model. Large-sample properties of the estimators are established. Simulation studies are carried out to evaluate the finite-sample performance of the estimation.
基金supported by the National Natural Science Foundation of China under Grant Nos.12171328,12001093,12231011,and 12071176the National Key Research and Development Program of China under Grant No.2020YFA0714102Beijing Natural Science Foundation under Grant No.Z210003。
文摘The paper discusses the regression analysis of current status data,which is common in various fields such as tumorigenic research and demographic studies.Analyzing this type of data poses a significant challenge and has recently gained considerable interest.Furthermore,the authors consider an even more difficult scenario where,apart from censoring,one also faces left-truncation and informative censoring,meaning that there is a potential correlation between the examination time and the failure time of interest.The authors propose a sieve maximum likelihood estimation(MLE)method and in the proposed method for inference,a copula-based procedure is applied to depict the informative censoring.Additionally,the authors utilise the splines to estimate the unknown nonparametric functions in the model,and the asymptotic properties of the proposed estimator are established.The simulation results indicate that the developed approach is effective in practice,and it has been successfully applied to a set of real data.
基金supported by the National Natural Science Foundation of China under Grant Nos. 12001093,12071176the National Key Research and Development Program of China under Grant No. 2020YFA0714102the Science and Technology Developing Plan of Jilin Province under Grant No. 20200201258JC
文摘Misclassified current status data arises if each study subject can only be observed once and the observation status is determined by a diagnostic test with imperfect sensitivity and specificity.For the situation,another issue that may occur is that the observation time may be correlated with the interested failure time,which is often referred to as informative censoring or observation times.It is well-known that in the presence of informative censoring,the analysis that ignores it could yield biased or even misleading results.In this paper,the authors consider such data and propose a frailty-based inference procedure.In particular,an EM algorithm based on Poisson latent variables is developed and the asymptotic properties of the resulting estimators are established.The numerical results show that the proposed method works well in practice and an application to a set of real data is provided.
基金partly supported by National Natural Science Foundation of China (Grant No. 10971015, 11131002)Key Project of Chinese Ministry of Education (Grant No. 309007)the Fundamental Research Funds for the Central Universities
文摘This paper discusses efficient estimation for the additive hazards regression model when only bivariate current status data are available. Current status data occur in many fields including demographical studies and tumorigenicity experiments （Keiding, 1991; Sun, 2006） and several approaches have been proposed for the additive hazards model with univariate current status data （Linet M., 1998; Martinussen and Scheike, 2002）. For bivariate data, in addition to facing the same problems as those with univariate data, one needs to deal with the association or correlation between two related failure time variables of interest. For this, we employ the copula model and an efficient estimation procedure is developed for inference. Simulation studies are performed to evaluate the proposed estimates and suggest that the approach works well in practical situations. An illustrative example is provided.
基金Supported by the National Natural Science Foundation of China(No.10771017,No.10231030)Key Project of Ministry of Education,PRC(No.309007)
文摘This article considers a semiparametric varying-coefficient partially linear regression model with current status data. The semiparametric varying-coefficient partially linear regression model which is a generalization of the partially linear regression model and varying-coefficient regression model that allows one to explore the possibly nonlinear effect of a certain covariate on the response variable. A Sieve maximum likelihood estimation method is proposed and the asymptotic properties of the proposed estimators are discussed. Under some mild conditions, the estimators are shown to be strongly consistent. The convergence rate of the estimator for the unknown smooth function is obtained and the estimator for the unknown parameter is shown to be asymptotically efficient and normally distributed. Simulation studies are conducted to examine the small-sample properties of the proposed estimates and a real dataset is used to illustrate our approach.
基金This research is supported in part by the National Natural Science Foundation of. China under Grant No. 10801133.
文摘Current status data often arise in survival analysis and reliability studies, when a continuous response is reduced to an indicator of whether the response is greater or less than an observed random threshold value. This article considers a partial linear model with current status data. A sieve least squares estimator is proposed to estimate both the regression parameters and the nonparametric function. This paper shows, under some mild condition, that the estimators are strong consistent. Moreover, the parameter estimators are normally distributed, while the nonparametric component achieves the optimal convergence rate. Simulation studies are carried out to investigate the performance of the proposed estimates. For illustration purposes, the method is applied to a real dataset from a study of the calcification of the hydrogel intraocular lenses, a complication of cataract treatment.
基金supported by Grants from the Natural Science Foundation of China[Grant Number 11731011]a grant from key project of the Yunnan Province Foundation,China[Grant Number 202001BB050049].
文摘Regression analysis of interval-censored failure time data has recently attracted a great deal of attention partly due to their increasing occurrences in many fields.In this paper,we discuss a type of such data,multivariate current status data,where in addition to the complex interval data structure,one also faces dependent or informative censoring.For inference,a sieve maximum likelihood estimation procedure is developed and the proposed estimators of regression parameters are shown to be asymptotically consistent and efficient.For the implementation of the method,an EM algorithm is provided,and the results from an extensive simulation study demonstrate the validity and good performance of the proposed inference procedure.For an illustration,the proposed approach is applied to a tumorigenicity experiment.
基金supported by National Natural Science Foundation of China under Grant No. 11001097
文摘Success-failure life tests are widely used in reliability engineering research to evaluate the storage life of products, where the observed data are the current status data, usually summarized as the form of ＂binomial life data＂. For this type of data, this paper proposes a two-stage algorithm to estimate some commonly used lifetime distributions. This Mgorithm is automatic, intuitively appealing and simple to implement. Simulation studies show that compared with some existing methods, the proposed algorithm is more stable and efficient, especially in small sample situations, and it can also be extended to deM with some complicated lifetime distributions.
