Rock-ice avalanches in cold high-mountain regions pose severe hazards due to their high mobility,yet the quantitative controls of particle-size ratio and ice content remain insufficiently constrained.This study invest...Rock-ice avalanches in cold high-mountain regions pose severe hazards due to their high mobility,yet the quantitative controls of particle-size ratio and ice content remain insufficiently constrained.This study investigates their coupled effects using inclinedflume experiments and Discrete Element Method(DEM)simulations,covering three gravel sizes(2-5 mm,5-7 mm,7-10 mm)and four ice-content levels(0%,20%,40%,60%).Run-out distance,velocity,energy components,flow regime(Savage number),and segregation indexαwere quantified.Increasing ice content significantly enhances mobility,but with diminishing marginal effectiveness.From 0%to 40%ice content,run-out distance increases by 41%-86%,whereas the additional increase from 40%to 60%contributes only 12%-23%.Particle-size ratio strongly governs segregation intensity.Fine-gravel groups reach segregation indices ofα=0.92-0.98,indicating nearly complete upward migration of ice,whereas medium-gravel and coarse-gravel groups exhibit much weaker segregation,stabilizing atα=0.68-0.74 and 0.60-0.69.Savage number analyses reveal marked flow-regime transitions.At 0%ice content,Savage numbers reach 1.0-1.5,indicating a collisional regime.Increasing ice content suppresses collisionality,with Savage numbers decreasing to 0.03-0.07 at 60%ice content,consistent with dense-regime flow.DEM energy analyses confirm this regime shift:for finegravel mixtures,collision energy decreases by 14%,while sliding-friction energy increases by 33%as ice content increases from 0%to 60%,reflecting enhanced overburden effects imposed by upward-segregated ice layers.Medium and coarse mixtures exhibit weaker or opposite energy-shift patterns,demonstrating strong size dependence.Mechanistically,large particle-size contrasts promote strong segregation and form dense basal rock layers that increase basal friction and reduce mobility.When particle sizes are similar or ice content is high,segregation remains limited,allowing ice to mix into the basal layer,thereby reducing basal friction and enhancing mobility.This research quantitatively demonstrates how composition controls particle spatial distribution,flow regime,and energy dissipation,offering new mechanistic insights into the propagation and deposition behaviors of rock-ice avalanches and improving hazard assessment in vulnerable high-mountain regions.展开更多
Negative Poisson’s ratio materials and structures exhibit lateral expansion under tensile loading,demonstrating significant mechanical advantages over conventional materials.This study systematically investigated thr...Negative Poisson’s ratio materials and structures exhibit lateral expansion under tensile loading,demonstrating significant mechanical advantages over conventional materials.This study systematically investigated three typical two-dimensional negative Poisson’s ratio metamaterial structures(Concave honeycomb,Anti-chiral,and Anti-chiral concave honeycomb hybrid structures)through both experimental tests and numerical analysis.The test specimens were fabricated using selective laser melting(SLM)additive manufacturing technology,and the experimental test was conducted with the use of a DIC strain measurement system.The numerical studies were performed considering both static tensile loading and dynamic impact loading with different strain rates.The deformation behaviors,failure process,negative Poisson’s ratio effects,and energy absorption capacity of the three different metamaterial structures are systematically investigated,and the associated mechanical mechanisms are thoroughly revealed.Results and findings of this work could provide valuable guidance for the engineering design and application of negative Poisson’s ratio metamaterials and structures.展开更多
As the prevalence of obesity increases dramatically,obesity-associated cardiac dysfunction constitutes a considerable challenge to human health.This study aimed to identify more useful lipid/inflammatory markers to pr...As the prevalence of obesity increases dramatically,obesity-associated cardiac dysfunction constitutes a considerable challenge to human health.This study aimed to identify more useful lipid/inflammatory markers to predict the risk of obesity-associated cardiac dysfunction.By retrospectively analyzing the clinical characteristics of 5648 cardiac disease patients,we found that both the plasma level of high-density lipoprotein cholesterol(HDLC)and the blood monocyte count were significantly associated with impairment of the left ventricular ejection fraction(LVEF).Univariate and multivariate regression analyses revealed that the monocyte to HDL-C ratio(MHR)was a more powerful predictor of the risk of LVEF decline than either HDL-C or monocyte alone.Mediation analysis further revealed a mediating effect of a high MHR on the decline in obesity-associated cardiac systolic function.Collectively,our results demonstrate a superior role of MHR in predicting the risk of an obesityassociated decline in cardiac systolic function among routine metabolic/inflammatory markers.展开更多
In modern construction,Lightweight Aggregate Concrete(LWAC)has been recognized as a vital material of concern because of its unique properties,such as reduced density and improved thermal insulation.Despite the extens...In modern construction,Lightweight Aggregate Concrete(LWAC)has been recognized as a vital material of concern because of its unique properties,such as reduced density and improved thermal insulation.Despite the extensive knowledge regarding its macroscopic properties,there is a wide knowledge gap in understanding the influence of microscale parameters like aggregate porosity and volume ratio on the mechanical response of LWAC.This study aims to bridge this knowledge gap,spurred by the need to enhance the predictability and applicability of LWAC in various construction environments.With the help of advanced numerical methods,including the finite element method and a random circular aggregate model,this study critically evaluates the role played by these microscale factors.We found that an increase in the aggregate porosity from 23.5%to 48.5%leads to a drastic change of weakness from the bonding interface to the aggregate,reducing compressive strength by up to 24.2%and tensile strength by 27.8%.Similarly,the increase in the volume ratio of lightweight aggregate from 25%to 40%leads to a reduction in compressive strength by 13.0%and tensile strength by 9.23%.These results highlight the imperative role of microscale properties on the mechanical properties of LWAC.By supplying precise quantitative details on the effect of porosity and aggregate volume ratio,this research makes significant contributions to construction materials science by providing useful recommendations for the creation and optimization of LWAC with improved performance and sustainability in construction.展开更多
Background:The long-term outcomes of robotic-assisted surgery and the prognostic significance of the pretreatment neutrophil-to-lymphocyte ratio(NLR)in locally advanced rectal cancer(LARC)remain uncertain.This study a...Background:The long-term outcomes of robotic-assisted surgery and the prognostic significance of the pretreatment neutrophil-to-lymphocyte ratio(NLR)in locally advanced rectal cancer(LARC)remain uncertain.This study aimed to assess the long-term outcomes of patients with LARC undergoing robotic-assisted surgery and to determine the prognostic value of pretreatment NLR.Methods:We retrospectively reviewed 252 patients with LARC who were treated at a single medical center in Taiwan between January 2012 and January 2023.All patients underwent neoadjuvant concurrent chemoradiotherapy(CRT)followed by robotic-assisted surgery with total mesorectal excision(TME).Patients were stratified into four groups on the basis of pretreatment NLRs and carcinoembryonic antigen(CEA)levels.Univariate and multivariate analyses were conducted to identify prognostic indicators for overall survival(OS)and disease-free survival(DFS).Results:Patients with a pretreatment NLR of≥3.2 exhibited significantly worse OS and DFS compared with those with an NLR of<3.2(OS:94.4 vs.116.5 months,p=0.001;DFS:78.8 vs.101.7 months,p=0.003).Group A exhibited the poorest prognosis,whereas Group D had the most favorable outcomes.Multivariate analysis revealed NLR≥3.2 as an independent predictor of poor OS(hazard ratio[HR]=2.306,95%CI:1.149-3.747;p=0.001)and DFS(HR=2.055,95%CI:1.341-3.148;p=0.001).Conclusion:Neoadjuvant concurrent CRT followed by robotic-assisted TME is an effective treatment strategy for LARC.A higher pretreatment NLR(≥3.2)independently predicted worse OS and DFS.Stratification using the NLR in combination with CEA levels may enhance prognostic accuracy for patients undergoing robotic-assisted surgery for LARC.展开更多
This study presents a framework involving statistical modeling and machine learning to accurately predict and optimize the mechanical and damping properties of hybrid granite-epoxy(G-E)composites reinforced with cast ...This study presents a framework involving statistical modeling and machine learning to accurately predict and optimize the mechanical and damping properties of hybrid granite-epoxy(G-E)composites reinforced with cast iron(CI)filler particles.Hybrid G-E composite with added cast iron(CI)filler particles enhances stiffness,strength,and vibration damping,offering enhanced performance for vibration-sensitive engineering applications.Unlike conventional approaches,this work simultaneously employs Artificial Neural Networks(ANN)for highaccuracy property prediction and Response Surface Methodology(RSM)for in-depth analysis of factor interactions and optimization.A total of 24 experimental test data sets of varying input factors(granite weight%,epoxy weight%,and CI filler weight%)were utilized to train and test the prediction models using an ANN approach and further analyze the interaction effects using RSM.Mechanical properties,including tensile,compressive,and flexural strength,elastic modulus,density and damping properties measured under various testing conditions,were set as output parameters for prediction.This study analyzed and optimized the performance of the ANN model using Bayesian Regularization and Levenberg-Marquardt algorithms to identify the best performing number of neurons in the hidden layer for achieving the highest prediction accuracy.The proposed ANN framework achieved an exceptional average determination coefficient(R2)exceeding 99%,with Bayesian Regularization demonstrating remarkable stability in the 22-neuron range and minimal variation across all properties.RSM and ANN form a powerful framework for predicting and optimizing hybrid G-E composite properties,enabling efficient design for vibration-critical applications with reduced experimental effort and performance optimization.展开更多
This study employed tri-component continuous monitoring data from 10 measurement points on both sides of a base isolation layer in the basement of a large-span high-rise building in Beijing,as well as from a free-fiel...This study employed tri-component continuous monitoring data from 10 measurement points on both sides of a base isolation layer in the basement of a large-span high-rise building in Beijing,as well as from a free-field station and roof frame,during a Mw 5.5 magnitude earthquake in Pingyuan,Shandong,in 2023.The H/V spectral ratio method was used to evaluate the structural dynamic response characteristics of the building and analyze the regulatory effect of the base-isolation layer on seismic waves.The results indicate that during the earthquake,the peak frequency of the free-field and the measurement points below the base-isolation layer was stable at 0.17 Hz,whereas the main frequency of the measurement points above the base-isolation layer increased to 0.75–1.18 Hz,which is 4–6 times greater than that of the points below.The amplitude was suppressed by more than 70%,confirming that the base isolation layer effectively isolated the low-frequency energy from the ground and increased the response frequency of the building.When the building was excited by an earthquake,a three-tier frequency gradient was formed throughout the building:“base-isolation layer(0.17 Hz)-main body(1.18 Hz)-roof frame(3.83 Hz)”,which can effectively avoid resonance of the entire building.In addition,the composite base-isolation device changed the dynamic characteristics of the structure.The resonance period was extended from 0.74 s(theoretical value without base isolation)to 5.9 s(calculated value),and the resonance frequency was reduced from 1.35 to 0.17 Hz.This finding indicates that the base-isolation layer can enhance seismic performance by increasing flexibility and damping.展开更多
Background:Panacis Quinquefolii Radix(PQR)is known for its ability to nourish“Qi”(it serves as the driving force for the functional activities of the body’s organs and meridians,promoting and regulating various phy...Background:Panacis Quinquefolii Radix(PQR)is known for its ability to nourish“Qi”(it serves as the driving force for the functional activities of the body’s organs and meridians,promoting and regulating various physiological functions)and“Yin”(it represents the material foundation of the human body.It plays a role in nourishing,moistening,and cooling the body).Notoginseng Radix et Rhizoma(NRR)is recognized for its properties of resolving blood stasis(it refers to a pathological condition characterized by impaired or stagnant blood circulation within the body).Changes in the compatibility ratio of these herbs often lead to variations in their chemical composition and efficacy.However,the specific alterations in chemical composition and efficacy resulting from compatibility adjustments remain unclear.We aimed to compare the material basis and their effects of different compatibility ratios of PQR and NRR on“Qi”deficiency and blood stasis syndrome(QBS).Methods:This study employed UPLC-Q/TOF-MS to identify effective compounds in the compatibility of PQR and NRR and utilized UPLC-TQ-MS/MS to analyze the dissolution of 16 saponins in PQR and NRR at 9 different ratios.A rat model of QBS was established,and the efficacy of PQR and NRR in treating this syndrome was assessed using hemorheology and coagulation analyses.Results:The study results show that PQR and NRR exhibit significant efficacy,effectively reducing blood viscosity induced by platelet aggregation and lowering inflammatory markers such as IL-6,IL-10,TXB2 and ET associated with vascular injury.Moreover,this combination regulates ATP and ADP levels,enhances energy metabolism,and promotes overall health.A total of 104 compounds in the compatibility of PQR and NRR were identified.The ratios of 1:2 and 1:3 showed the highest total saponin content,but the ratio of 1:1 demonstrated a superior pharmacological effect for the treatment of QBS.Conclusion:In summary,the compatibility of PQR and NRR not only shows the complex interactions between traditional Chinese medicinal materials,but also provides a new idea and method for the treatment of QBS.展开更多
BACKGROUND The diagnosis of gastric carcinoma(GC)is essential for improving clinical outcomes.However,the biomarkers currently used for GC screening are not ideal.AIM To explore the diagnostic implications of the neut...BACKGROUND The diagnosis of gastric carcinoma(GC)is essential for improving clinical outcomes.However,the biomarkers currently used for GC screening are not ideal.AIM To explore the diagnostic implications of the neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),and systemic immune-inflammatory index(SII)for GC.METHODS The baseline data of 133 patients with GC and 134 patients with precancerous gastric conditions admitted between January 2022 and December 2023 were retrospectively analyzed.The information on peripheral blood platelet,neutrophil,and lymphocyte counts in each patient was collected,and the NLR,PLR,and SII levels of both groups were calculated.Additionally,multivariate logistic regression analysis was conducted,and the diagnostic implications of NLR,PLR,and SII in differentiating patients with precancerous gastric conditions,compared with those with GC,were analyzed through receiver operating characteristic(ROC)curves.RESULTS The data indicated that NLR,PLR,and SII had abnormally increased levels in the patients with GC.Gender and body mass index were risk factors for the occurrence of GC.ROC data revealed that the areas under the curve of three patients with precancerous gastric conditions,who were differentiated from those with GC,were 0.824,0.787,and 0.842,respectively.CONCLUSION NLR,PLR,and SII are all abnormally expressed in GC and have diagnostic implications,especially when used as joint indicators,in distinguishing patients with precancerous gastric conditions from those with GC.展开更多
BACKGROUND The use of biomarkers,such as the neutrophil-to-lymphocyte ratio(NLR)and the neutrophil-to-platelet ratio(NPR),has shown promise in evaluating early outcomes after medical,interventional,and surgical treatm...BACKGROUND The use of biomarkers,such as the neutrophil-to-lymphocyte ratio(NLR)and the neutrophil-to-platelet ratio(NPR),has shown promise in evaluating early outcomes after medical,interventional,and surgical treatments.NLR has emer-ged as an indicator of systemic inflammation and physiological stress.NPR has emerged as a potential indicator of inflammation and thrombotic risk in the context of surgical and radiological procedures.AIM To analyze the correlation of NLR and NPR with the development of post-liver transplantation(LT)early complications after stratification for hepatocellular carcinoma diagnosis.METHODS Consecutive patients undergone LT between January 2019 and December 2023 were enrolled.Data regarding the concentration of hemoglobin and the differ-ential leukocyte count on postoperative days(POD)0,1,3,and 5 were collected.RESULTS The dataset included 161 consecutive patients undergone LT.Clavien-Dindo IV-V complications had a good correlation with NLR POD 1(P=0.05),NLR POD 3(P<0.001),NLR POD 7(P<0.001),NPR POD 3(P<0.001).In addition,the NPR ratio on POD 3 correlated with the onset of 30-day hemorrhage(P=0.009).Finally,30-day mortality had a significant association with the NLR POD 1(P=0.03)and with NLR POD 7(P=0.004),while NPR had a significant correlation with 30-day mortality in NPR POD 7(P=0.004).CONCLUSION The analysis of NLR and NPR are strictly correlated with Clavien-Dindo IV-V complications and 30-day post-LT death.展开更多
Objective Peritoneal carcinomatosis(PC)is a common pattern of recurrence in gastric cancer patients and is associated with a poor prognosis.This study aimed to evaluate the predictive value of the albumin-fibrinogen r...Objective Peritoneal carcinomatosis(PC)is a common pattern of recurrence in gastric cancer patients and is associated with a poor prognosis.This study aimed to evaluate the predictive value of the albumin-fibrinogen ratio(AFR)for PC in patients with gastric cancer and to develop two preoperative prediction models.Methods A total of 745 gastric cancer patients were included in this study.Preoperative AFR,along with other serum markers and clinical tumor characteristics,was assessed.Univariate and multivariate logistic regression analyses were performed to determine the odds ratios(ORs)and 95%confidence intervals(CIs)of the independent variables.Propensity score matching(PSM)was used to control for potential confounders,and one-way ANOVA was conducted to evaluate differences in distribution between groups.Two prediction models incorporating the independent predictive indicators were constructed and validated via receiver operating characteristic(ROC)curves.Results Poorly differentiated type(OR 2.679;P=0.001),nondiffuse morphological type(OR 2.123;P=0.040),BMI<23.550 kg/m^(2)(OR 4.635;P=0.001),AFR<11.275(OR 2.895;P=0.003)and CA199≥73.615 U/mL(OR 2.040;P=0.037)were identified as independent risk factors for PC in patients with gastric cancer.After PSM,the AFR remained the only inflammatory marker that was independently associated with PC(P=0.003).AFR demonstrated consistent robustness in predicting PC across multiple sample sets.Among all the independent risk factors,the AFR had the highest area under the curve(AUC)for ROC analysis(AUC 0.648;95%CI 0.580–0.715).Two combination models incorporating the AFR demonstrated enhanced predictive ability:Combination Model 1(AUC 0.759;95%CI 0.699–0.820)and Combination Model 2(AUC 0.801;95%CI 0.744–0.859).Conclusions The preoperative AFR serves as a useful indicator for predicting PC.Two reliable prediction models based on the AFR have been developed.展开更多
The low-melting glass of Bi2O_(3)-B2O_(3)-SiO_(2)(BiBSi)system was used for the first time for laser sealing of vacuum glazing.Under the condition of constant boron content,how the structure and properties vary with B...The low-melting glass of Bi2O_(3)-B2O_(3)-SiO_(2)(BiBSi)system was used for the first time for laser sealing of vacuum glazing.Under the condition of constant boron content,how the structure and properties vary with Bi/Si ratio in low-melting glass was investigated.In addition,the relationships between laser power,low-melting glass solder with different Bi/Si ratios and laser sealing shear strength were revealed.The results show that a decrease in the Bi/Si ratio can cause a contraction of the glass network of the low-melting glass,leading to an increase of its characteristic temperature and a decrease of its coefficient of thermal expansion.During laser sealing,the copper ions in the low-melting glass play an endothermic role.A change in the Bi/Si ratio will affect the valence state transition of the copper ions in the low-melting glass.The absorbance of the low-melting glass does not follow the expected correlation with the Bi/Si ratio,but shows a linear correlation with the content of divalent copper ions.The greater the concentration of divalent copper ions,the greater the absorbance of the low-melting glass,and the lower the laser power required for laser sealing.The shear strength of the low melting glass solder after laser sealing was tested,and it was found that the maximum shear strength of Z1 glass sample was the highest up to 2.67 MPa.展开更多
Increasing the hole expansion ratio is significant for developing high formability parts.Hole expansion tests were carried out on low carbon hot-rolled steel containing 0.11%Ti,0.072%Ti–0.03%Nb and 0.097%Ti–0.059%Nb...Increasing the hole expansion ratio is significant for developing high formability parts.Hole expansion tests were carried out on low carbon hot-rolled steel containing 0.11%Ti,0.072%Ti–0.03%Nb and 0.097%Ti–0.059%Nb,respectively.The effects of microstructure,texture,crack propagation behavior and second phase precipitation behavior on hole expansion ratio were investigated.The precipitation behavior of TiC and(Ti,Nb)C in austenite and ferrite in three groups of steel samples was calculated theoretically.The results showed that the hole expansion ratios of 0.11Ti,0.072Ti–0.03Nb and 0.097Ti–0.059Nb test steels were 51.73%,51.17%and 66.24%following simulated coiling at 600℃,respectively.The microstructure was mainly polygonal ferrite with a small amount of pearlite.The grain refinement of 0.097Ti–0.059Nb test steel and the low texture ratio of{110}//ND improved the hole expansion ratio.The low overall hole expansion ratio was due to the microstructure inhomogeneity.The microstructure uniformity was improved by the quenching and tempering treatment,and the hole expansion ratio of the three test steels was greatly increased.The fastest precipitation temperatures in the austenitic region of 0.11Ti,0.072Ti–0.03Nb and 0.097Ti–0.059Nb test steels were 880,860 and 830℃,while those in the ferrite region were 680,675 and 675℃,respectively.The addition of Nb element increased the volume free energy,so that the critical core size of the nucleation on the dislocation line increased,resulting in the decrease in the fastest precipitation temperature.展开更多
It is well known that coarse-grained super-elastic NiTi shape memory alloys(SMAs)exhibit localized rather than homogeneous martensite transformation(MT),which,however,can be strongly influenced by either internal size...It is well known that coarse-grained super-elastic NiTi shape memory alloys(SMAs)exhibit localized rather than homogeneous martensite transformation(MT),which,however,can be strongly influenced by either internal size(grain size,GS)or the external size(geometric size).The coupled effect of GS and geometric size on the functional properties has not been clearly understood yet.In this work,the super-elasticity,one-way,and stress-assisted two-way shape memory effects of the polycrystalline NiTi SMAs with different aspect ratios(length/width for the gauge section)and different GSs are investigated based on the phase field method.The coupled effect of the aspect ratio and GS on the functional properties is adequately revealed.The simulated results indicate that when the aspect ratio is lower than about 4:1,the stress biaxiality and stress heterogeneity in the gauge section of the sample become more and more obvious with decreasing the aspect ratio,which can significantly influence the microstructure evolution in the process involving external stress.Therefore,the corresponding functional property is strongly dependent on the aspect ratio.With decreasing the GS and the aspect ratio(to be lower than 4:1),both the aspect ratio and GS can affect the MT or martensite reorientation in each grain and the interaction among grains.Thus,due to the strong internal constraint(i.e.,the constraint of grain boundary)and the external constraint(i.e.,the constraint of geometric boundary),the capabilities of the functional properties of NiTi SMAs are gradually weakened and highly dependent on these two factors.展开更多
Gastric cancer(GC)is a leading cause of cancer-related deaths,highlighting the need for reliable prognostic biomarkers to guide treatment.Wei et al’s systematic review and meta-analysis evaluates the neutrophil-to-ly...Gastric cancer(GC)is a leading cause of cancer-related deaths,highlighting the need for reliable prognostic biomarkers to guide treatment.Wei et al’s systematic review and meta-analysis evaluates the neutrophil-to-lymphocyte ratio(NLR)as a potential biomarker for GC patients undergoing neoadjuvant chemotherapy.NLR is a simple and cost-effective measure of systemic inflammation that shows promise in predicting treatment response and survival outcomes,including overall survival and progression-free survival.However,variations in NLR thresholds and timing of measurements affect its accuracy and clinical utility.Moreover,the studies reviewed primarily involved Asian populations,which may limit the generalizability of the findings.To improve NLR’s clinical relevance,future research should focus on standardizing NLR thresholds,refining measurement timing,and incorporating additional inflammatory markers like platelet-to-lymphocyte ratio and Glasgow prognostic score.Addressing con-founders and including diverse patient populations will help improve NLR’s reliability as a prognostic marker for GC.展开更多
This study employed a wet impregnation method to synthesize five types of Cu/HZSM-5 adsorbents with Si/Al ratios of 25,50,85,200,and 300,used for the removal of H_(2)S in lowtemperature,low-oxygen environments.The imp...This study employed a wet impregnation method to synthesize five types of Cu/HZSM-5 adsorbents with Si/Al ratios of 25,50,85,200,and 300,used for the removal of H_(2)S in lowtemperature,low-oxygen environments.The impact of different Si/Al ratios on the adsorption oxidative performance of Cu_(30)/HZSM-5–85 adsorbents was investigated.According to the performance test results,Cu_(30)/HZSM-5–85 exhibited the highest breakthrough capacity,reaching 231.75 mg H_(2)S/g_(sorbent).Cu/HZSM-5 sorbent maintains a strong ability to remove H_(2)S even under humid conditions and shows excellent water resistance.XRD,BET,and XPS results revealed that CuO is the primary active species,with Cu_(30)/HZSM-5–85 having the largest surface area and highest CuO content,providing more active sites for H_(2)S adsorption.H_(2)-TPR and O_(2)-TPD results confirmed that Cu_(30)/HZSM-5–85 sorbent exhibits outstanding redox properties and oxygen storage capacity,contributing to excellent oxygen transferability in the molecular sieve adsorption-oxidation process.With notable characteristics such as a large surface area,high desulfurization efficiency,and water resistance,Cu_(30)/HZSM-5–85 sorbents hold significant importance for industrial applications.展开更多
BACKGROUND Non-ST segment elevation myocardial infarction(NSTEMI)poses significant challenges in clinical management due to its diverse outcomes.Understanding the prognostic role of hematological parameters and derive...BACKGROUND Non-ST segment elevation myocardial infarction(NSTEMI)poses significant challenges in clinical management due to its diverse outcomes.Understanding the prognostic role of hematological parameters and derived ratios in NSTEMI patients could aid in risk stratification and improve patient care.AIM To evaluate the predictive value of hemogram-derived ratios for major adverse cardiovascular events(MACE)in NSTEMI patients,potentially improving clinical outcomes.METHODS A prospective,observational cohort study was conducted in 2021 at the Internal Medicine Clinic of the University Hospital in Tuzla,Bosnia and Herzegovina.The study included 170 patients with NSTEMI,who were divided into a group with MACE and a control group without MACE.Furthermore,the MACE group was subdivided into lethal and non-lethal groups for prognostic analysis.Alongside hematological parameters,an additional 13 hematological-derived ratios(HDRs)were monitored,and their prognostic role was investigated.RESULTS Hematological parameters did not significantly differ between non-ST segment elevation myocardial infarction(NSTEMI)patients with MACE and a control group at T1 and T2.However,significant disparities emerged in HDRs among NSTEMI patients with lethal and non-lethal outcomes post-MACE.Notably,neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)were elevated in lethal outcomes.Furthermore,C-reactive protein-to-lymphocyte ratio(CRP/Ly)at T1(>4.737)demonstrated predictive value[odds ratio(OR):3.690,P=0.024].Both NLR at T1(>4.076)and T2(>4.667)emerged as significant predictors,with NLR at T2 exhibiting the highest diagnostic performance,as indicated by an area under the curve of 0.811(95%CI:0.727-0.859)and OR of 4.915(95%CI:1.917-12.602,P=0.001),emphasizing its important role as a prognostic marker.CONCLUSION This study highlights the significant prognostic value of hemogram-derived indexes in predicting MACE among NSTEMI patients.During follow-up,NLR,PLR,and CRP/Ly offer important insights into the inflammatory processes underlying cardiovascular events.展开更多
With the continuous application of new technologies in reconnaissance and attack, false camouflage plays a more important role in improving the survivability of targets, and the number of decoys plays a crucial role i...With the continuous application of new technologies in reconnaissance and attack, false camouflage plays a more important role in improving the survivability of targets, and the number of decoys plays a crucial role in the camouflaging effect. Based on the concept of cost-effectiveness ratio, according to the newly formulated Johnson criterion and the view of discovery and destruction, this paper proposes to take the identification probability as the probability of being destroyed and uses mathematical formulas to calculate the cost of a single use decoy. On this basis, a cost-effectiveness ratio model is established, with the product of the increase in the survival probability of the target and the cost of the target as the benefit, and the sum of the product of the probability of being destroyed and the cost of the decoy and the cost of a single use as the consumption cost. The model is calculated and analyzed, and the number of decoys that conform to the actual situation is obtained.展开更多
BACKGROUND An efficient index holds the potential to predict rectal cancer prognosis.AIM To investigate the impact of neutrophil-to-lymphocyte ratio(NLR),platelet-tolymphocyte ratio(PLR),and monocyte-to-lymphocyte rat...BACKGROUND An efficient index holds the potential to predict rectal cancer prognosis.AIM To investigate the impact of neutrophil-to-lymphocyte ratio(NLR),platelet-tolymphocyte ratio(PLR),and monocyte-to-lymphocyte ratio(MLR)on rectal cancer prognosis.METHODS This retrospective study involved 180 patients with rectal cancer from the Changzhi People’s Hospital of Shanxi Province.A 2-mL blood sample was collected at 24 h preoperatively and 72 h postoperatively to measure neutrophils,lymphocytes,platelets,and monocytes using an automatic blood analyzer.Preoperative and postoperative NLR,PLR,and MLR were compared.Patients were followed up for 12 months and categorized into good and poor prognosis groups.A receiver operating characteristic curve was constructed to analyze their predictive values.RESULTS The NLR,PLR,and MLR values were significantly lower post-surgery(P<0.05).A total of 152 and 28 patients were categorized in the good and poor prognosis groups,respectively.Patients with poor prognoses exhibited slightly higher postoperative NLR,PLR,and MLR values than those with good prognoses(P<0.05).Receiver operating characteristic analysis showed that the area under the curve for NLR,PLR,and MLR was 0.828 with a sensitivity and specificity of 89.29%and 90.79%,respectively.These values were higher than individual NLR(area under the curve:0.660,sensitivity:67.86%,specificity:54.61%),PLR(0.668,75.00%,55.30%),and MLR(0.635,60.71%,48.03%),all showing statistically significant differences(P<0.05),effectively predicting patient outcomes.CONCLUSION The findings of this study indicated that NLR,PLR,and MLR values of patients with rectal cancer can be used to effectively predict the outcome of patients.展开更多
BACKGROUND The clinical impact of post-percutaneous coronary intervention (PCI) quantitative flow ratio (QFR) in patients treated with PCI for chronic total occlusion (CTO) was still undetermined.METHODS All CTO vesse...BACKGROUND The clinical impact of post-percutaneous coronary intervention (PCI) quantitative flow ratio (QFR) in patients treated with PCI for chronic total occlusion (CTO) was still undetermined.METHODS All CTO vessels treated with successful anatomical PCI in patients from PANDA Ⅲ trial were retrospectively measured for postPCI QFR.The primary outcome was 2-year vessel-oriented composite endpoints (VOCEs,composite of target vessel-related cardiac death,target vessel-related myocardial infarction,and ischemia-driven target vessel revascularization).Receiver operator characteristic curve analysis was conducted to identify optimal cutoff value of post-PCI QFR for predicting the 2-year VOCEs,and all vessels were stratified by this optimal cutoff value.Cox proportional hazards models were employed to calculate the hazard ratio (HR) with 95% CI.RESULTS Among 428 CTO vessels treated with PCI,353 vessels (82.5%) were analyzable for post-PCI QFR.31 VOCEs (8.7%) occurred at 2 years.Mean value of post-PCI QFR was 0.92±0.13.Receiver operator characteristic curve analysis shown the optimal cutoff value of post-PCI QFR for predicting 2-year VOCEs was 0.91.The incidence of 2-year VOCEs in the vessel with post-PCI QFR<0.91 (n=91) was significantly higher compared with the vessels with post-PCI QFR≥0.91 (n=262)(22.0%vs.4.2%,HR=4.98,95%CI:2.32–10.70).CONCLUSIONS Higher post-PCI QFR values were associated with improved prognosis in the PCI practice for coronary CTO.Achieving functionally optimal PCI results (post-PCI QFR value≥0.91) tends to get better prognosis for patients with CTO lesions.展开更多
基金funded by the Natural Science Foundation of China(Grants No 42277127)。
文摘Rock-ice avalanches in cold high-mountain regions pose severe hazards due to their high mobility,yet the quantitative controls of particle-size ratio and ice content remain insufficiently constrained.This study investigates their coupled effects using inclinedflume experiments and Discrete Element Method(DEM)simulations,covering three gravel sizes(2-5 mm,5-7 mm,7-10 mm)and four ice-content levels(0%,20%,40%,60%).Run-out distance,velocity,energy components,flow regime(Savage number),and segregation indexαwere quantified.Increasing ice content significantly enhances mobility,but with diminishing marginal effectiveness.From 0%to 40%ice content,run-out distance increases by 41%-86%,whereas the additional increase from 40%to 60%contributes only 12%-23%.Particle-size ratio strongly governs segregation intensity.Fine-gravel groups reach segregation indices ofα=0.92-0.98,indicating nearly complete upward migration of ice,whereas medium-gravel and coarse-gravel groups exhibit much weaker segregation,stabilizing atα=0.68-0.74 and 0.60-0.69.Savage number analyses reveal marked flow-regime transitions.At 0%ice content,Savage numbers reach 1.0-1.5,indicating a collisional regime.Increasing ice content suppresses collisionality,with Savage numbers decreasing to 0.03-0.07 at 60%ice content,consistent with dense-regime flow.DEM energy analyses confirm this regime shift:for finegravel mixtures,collision energy decreases by 14%,while sliding-friction energy increases by 33%as ice content increases from 0%to 60%,reflecting enhanced overburden effects imposed by upward-segregated ice layers.Medium and coarse mixtures exhibit weaker or opposite energy-shift patterns,demonstrating strong size dependence.Mechanistically,large particle-size contrasts promote strong segregation and form dense basal rock layers that increase basal friction and reduce mobility.When particle sizes are similar or ice content is high,segregation remains limited,allowing ice to mix into the basal layer,thereby reducing basal friction and enhancing mobility.This research quantitatively demonstrates how composition controls particle spatial distribution,flow regime,and energy dissipation,offering new mechanistic insights into the propagation and deposition behaviors of rock-ice avalanches and improving hazard assessment in vulnerable high-mountain regions.
基金supported by the National Natural Science Foundation of China(No.12472136)Innovation Fund of Marine Defense Technology Innovation Center(No.25GFC-JJ16-3608).
文摘Negative Poisson’s ratio materials and structures exhibit lateral expansion under tensile loading,demonstrating significant mechanical advantages over conventional materials.This study systematically investigated three typical two-dimensional negative Poisson’s ratio metamaterial structures(Concave honeycomb,Anti-chiral,and Anti-chiral concave honeycomb hybrid structures)through both experimental tests and numerical analysis.The test specimens were fabricated using selective laser melting(SLM)additive manufacturing technology,and the experimental test was conducted with the use of a DIC strain measurement system.The numerical studies were performed considering both static tensile loading and dynamic impact loading with different strain rates.The deformation behaviors,failure process,negative Poisson’s ratio effects,and energy absorption capacity of the three different metamaterial structures are systematically investigated,and the associated mechanical mechanisms are thoroughly revealed.Results and findings of this work could provide valuable guidance for the engineering design and application of negative Poisson’s ratio metamaterials and structures.
基金supported by grants from the National Natural Science Foundation of China(Grant Nos.82430018 to Q.C.,82270361 and 82570402 to H.Z.)the Nanjing Medical University Undergraduate Innovation and Entrepreneurship Training Program Fund(Grant No.202410312138Y to C.Z.)the Basic Sciences of Jiangsu Higher Education Institutions(Grant No.22KJA310002 to H.Z.)。
文摘As the prevalence of obesity increases dramatically,obesity-associated cardiac dysfunction constitutes a considerable challenge to human health.This study aimed to identify more useful lipid/inflammatory markers to predict the risk of obesity-associated cardiac dysfunction.By retrospectively analyzing the clinical characteristics of 5648 cardiac disease patients,we found that both the plasma level of high-density lipoprotein cholesterol(HDLC)and the blood monocyte count were significantly associated with impairment of the left ventricular ejection fraction(LVEF).Univariate and multivariate regression analyses revealed that the monocyte to HDL-C ratio(MHR)was a more powerful predictor of the risk of LVEF decline than either HDL-C or monocyte alone.Mediation analysis further revealed a mediating effect of a high MHR on the decline in obesity-associated cardiac systolic function.Collectively,our results demonstrate a superior role of MHR in predicting the risk of an obesityassociated decline in cardiac systolic function among routine metabolic/inflammatory markers.
基金supported by National Science Foundation of China(10972015,11172015)the Beijing Natural Science Foundation(8162008).
文摘In modern construction,Lightweight Aggregate Concrete(LWAC)has been recognized as a vital material of concern because of its unique properties,such as reduced density and improved thermal insulation.Despite the extensive knowledge regarding its macroscopic properties,there is a wide knowledge gap in understanding the influence of microscale parameters like aggregate porosity and volume ratio on the mechanical response of LWAC.This study aims to bridge this knowledge gap,spurred by the need to enhance the predictability and applicability of LWAC in various construction environments.With the help of advanced numerical methods,including the finite element method and a random circular aggregate model,this study critically evaluates the role played by these microscale factors.We found that an increase in the aggregate porosity from 23.5%to 48.5%leads to a drastic change of weakness from the bonding interface to the aggregate,reducing compressive strength by up to 24.2%and tensile strength by 27.8%.Similarly,the increase in the volume ratio of lightweight aggregate from 25%to 40%leads to a reduction in compressive strength by 13.0%and tensile strength by 9.23%.These results highlight the imperative role of microscale properties on the mechanical properties of LWAC.By supplying precise quantitative details on the effect of porosity and aggregate volume ratio,this research makes significant contributions to construction materials science by providing useful recommendations for the creation and optimization of LWAC with improved performance and sustainability in construction.
基金supported by grants through funding from the National Science and Technology Council(NSTC112-2314-B-037-050-MY3,NSTC114-2314-B-037-103-MY3,NSTC114-2321-B-037-003)the Ministry of Health and Welfare(MOHW113-TDU-B-222-134014)+3 种基金funded by the health and welfare surcharge of on tobacco products,and the Kaohsiung Medical University Hospital(KMUH113-3R31,KMUH113-3R32,KMUH113-3R33,KMUH113-3M58,KMUH113-3M59,KMUH-S11412,KMUH-SH11403)Kaohsiung Medical University Research Center Grant(KMU-TC113A04)National Tsing Hua University-Kaohsiung Medical University Joint Research Project(NTHU-KMU-KT114P008)supported by the Grant of Taiwan Precision Medicine Initiative and Taiwan Biobank,Academia Sinica,Taiwan.
文摘Background:The long-term outcomes of robotic-assisted surgery and the prognostic significance of the pretreatment neutrophil-to-lymphocyte ratio(NLR)in locally advanced rectal cancer(LARC)remain uncertain.This study aimed to assess the long-term outcomes of patients with LARC undergoing robotic-assisted surgery and to determine the prognostic value of pretreatment NLR.Methods:We retrospectively reviewed 252 patients with LARC who were treated at a single medical center in Taiwan between January 2012 and January 2023.All patients underwent neoadjuvant concurrent chemoradiotherapy(CRT)followed by robotic-assisted surgery with total mesorectal excision(TME).Patients were stratified into four groups on the basis of pretreatment NLRs and carcinoembryonic antigen(CEA)levels.Univariate and multivariate analyses were conducted to identify prognostic indicators for overall survival(OS)and disease-free survival(DFS).Results:Patients with a pretreatment NLR of≥3.2 exhibited significantly worse OS and DFS compared with those with an NLR of<3.2(OS:94.4 vs.116.5 months,p=0.001;DFS:78.8 vs.101.7 months,p=0.003).Group A exhibited the poorest prognosis,whereas Group D had the most favorable outcomes.Multivariate analysis revealed NLR≥3.2 as an independent predictor of poor OS(hazard ratio[HR]=2.306,95%CI:1.149-3.747;p=0.001)and DFS(HR=2.055,95%CI:1.341-3.148;p=0.001).Conclusion:Neoadjuvant concurrent CRT followed by robotic-assisted TME is an effective treatment strategy for LARC.A higher pretreatment NLR(≥3.2)independently predicted worse OS and DFS.Stratification using the NLR in combination with CEA levels may enhance prognostic accuracy for patients undergoing robotic-assisted surgery for LARC.
文摘This study presents a framework involving statistical modeling and machine learning to accurately predict and optimize the mechanical and damping properties of hybrid granite-epoxy(G-E)composites reinforced with cast iron(CI)filler particles.Hybrid G-E composite with added cast iron(CI)filler particles enhances stiffness,strength,and vibration damping,offering enhanced performance for vibration-sensitive engineering applications.Unlike conventional approaches,this work simultaneously employs Artificial Neural Networks(ANN)for highaccuracy property prediction and Response Surface Methodology(RSM)for in-depth analysis of factor interactions and optimization.A total of 24 experimental test data sets of varying input factors(granite weight%,epoxy weight%,and CI filler weight%)were utilized to train and test the prediction models using an ANN approach and further analyze the interaction effects using RSM.Mechanical properties,including tensile,compressive,and flexural strength,elastic modulus,density and damping properties measured under various testing conditions,were set as output parameters for prediction.This study analyzed and optimized the performance of the ANN model using Bayesian Regularization and Levenberg-Marquardt algorithms to identify the best performing number of neurons in the hidden layer for achieving the highest prediction accuracy.The proposed ANN framework achieved an exceptional average determination coefficient(R2)exceeding 99%,with Bayesian Regularization demonstrating remarkable stability in the 22-neuron range and minimal variation across all properties.RSM and ANN form a powerful framework for predicting and optimizing hybrid G-E composite properties,enabling efficient design for vibration-critical applications with reduced experimental effort and performance optimization.
基金supported by the Deep Earth Probe and Mineral Resources Exploration-National Science and Technology Major Project(Grant No.2025ZD005100)by Beijing Geolight Technology Co.,Ltd.under the project“The Impact of Strong Ground Motion on Buildings”(YF-202520).
文摘This study employed tri-component continuous monitoring data from 10 measurement points on both sides of a base isolation layer in the basement of a large-span high-rise building in Beijing,as well as from a free-field station and roof frame,during a Mw 5.5 magnitude earthquake in Pingyuan,Shandong,in 2023.The H/V spectral ratio method was used to evaluate the structural dynamic response characteristics of the building and analyze the regulatory effect of the base-isolation layer on seismic waves.The results indicate that during the earthquake,the peak frequency of the free-field and the measurement points below the base-isolation layer was stable at 0.17 Hz,whereas the main frequency of the measurement points above the base-isolation layer increased to 0.75–1.18 Hz,which is 4–6 times greater than that of the points below.The amplitude was suppressed by more than 70%,confirming that the base isolation layer effectively isolated the low-frequency energy from the ground and increased the response frequency of the building.When the building was excited by an earthquake,a three-tier frequency gradient was formed throughout the building:“base-isolation layer(0.17 Hz)-main body(1.18 Hz)-roof frame(3.83 Hz)”,which can effectively avoid resonance of the entire building.In addition,the composite base-isolation device changed the dynamic characteristics of the structure.The resonance period was extended from 0.74 s(theoretical value without base isolation)to 5.9 s(calculated value),and the resonance frequency was reduced from 1.35 to 0.17 Hz.This finding indicates that the base-isolation layer can enhance seismic performance by increasing flexibility and damping.
基金funded by the Entrusted service project of Shaanxi Administration of Traditional Chinese Medicine(ZYJXG-L23001)2023 Sanqin Talent Special Support Program Innovation and Entrepreneurship Team Project,and Sci-Tech Innovation Talent System Construction Program of Shaanxi University of Chinese Medicine(2023).
文摘Background:Panacis Quinquefolii Radix(PQR)is known for its ability to nourish“Qi”(it serves as the driving force for the functional activities of the body’s organs and meridians,promoting and regulating various physiological functions)and“Yin”(it represents the material foundation of the human body.It plays a role in nourishing,moistening,and cooling the body).Notoginseng Radix et Rhizoma(NRR)is recognized for its properties of resolving blood stasis(it refers to a pathological condition characterized by impaired or stagnant blood circulation within the body).Changes in the compatibility ratio of these herbs often lead to variations in their chemical composition and efficacy.However,the specific alterations in chemical composition and efficacy resulting from compatibility adjustments remain unclear.We aimed to compare the material basis and their effects of different compatibility ratios of PQR and NRR on“Qi”deficiency and blood stasis syndrome(QBS).Methods:This study employed UPLC-Q/TOF-MS to identify effective compounds in the compatibility of PQR and NRR and utilized UPLC-TQ-MS/MS to analyze the dissolution of 16 saponins in PQR and NRR at 9 different ratios.A rat model of QBS was established,and the efficacy of PQR and NRR in treating this syndrome was assessed using hemorheology and coagulation analyses.Results:The study results show that PQR and NRR exhibit significant efficacy,effectively reducing blood viscosity induced by platelet aggregation and lowering inflammatory markers such as IL-6,IL-10,TXB2 and ET associated with vascular injury.Moreover,this combination regulates ATP and ADP levels,enhances energy metabolism,and promotes overall health.A total of 104 compounds in the compatibility of PQR and NRR were identified.The ratios of 1:2 and 1:3 showed the highest total saponin content,but the ratio of 1:1 demonstrated a superior pharmacological effect for the treatment of QBS.Conclusion:In summary,the compatibility of PQR and NRR not only shows the complex interactions between traditional Chinese medicinal materials,but also provides a new idea and method for the treatment of QBS.
文摘BACKGROUND The diagnosis of gastric carcinoma(GC)is essential for improving clinical outcomes.However,the biomarkers currently used for GC screening are not ideal.AIM To explore the diagnostic implications of the neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),and systemic immune-inflammatory index(SII)for GC.METHODS The baseline data of 133 patients with GC and 134 patients with precancerous gastric conditions admitted between January 2022 and December 2023 were retrospectively analyzed.The information on peripheral blood platelet,neutrophil,and lymphocyte counts in each patient was collected,and the NLR,PLR,and SII levels of both groups were calculated.Additionally,multivariate logistic regression analysis was conducted,and the diagnostic implications of NLR,PLR,and SII in differentiating patients with precancerous gastric conditions,compared with those with GC,were analyzed through receiver operating characteristic(ROC)curves.RESULTS The data indicated that NLR,PLR,and SII had abnormally increased levels in the patients with GC.Gender and body mass index were risk factors for the occurrence of GC.ROC data revealed that the areas under the curve of three patients with precancerous gastric conditions,who were differentiated from those with GC,were 0.824,0.787,and 0.842,respectively.CONCLUSION NLR,PLR,and SII are all abnormally expressed in GC and have diagnostic implications,especially when used as joint indicators,in distinguishing patients with precancerous gastric conditions from those with GC.
文摘BACKGROUND The use of biomarkers,such as the neutrophil-to-lymphocyte ratio(NLR)and the neutrophil-to-platelet ratio(NPR),has shown promise in evaluating early outcomes after medical,interventional,and surgical treatments.NLR has emer-ged as an indicator of systemic inflammation and physiological stress.NPR has emerged as a potential indicator of inflammation and thrombotic risk in the context of surgical and radiological procedures.AIM To analyze the correlation of NLR and NPR with the development of post-liver transplantation(LT)early complications after stratification for hepatocellular carcinoma diagnosis.METHODS Consecutive patients undergone LT between January 2019 and December 2023 were enrolled.Data regarding the concentration of hemoglobin and the differ-ential leukocyte count on postoperative days(POD)0,1,3,and 5 were collected.RESULTS The dataset included 161 consecutive patients undergone LT.Clavien-Dindo IV-V complications had a good correlation with NLR POD 1(P=0.05),NLR POD 3(P<0.001),NLR POD 7(P<0.001),NPR POD 3(P<0.001).In addition,the NPR ratio on POD 3 correlated with the onset of 30-day hemorrhage(P=0.009).Finally,30-day mortality had a significant association with the NLR POD 1(P=0.03)and with NLR POD 7(P=0.004),while NPR had a significant correlation with 30-day mortality in NPR POD 7(P=0.004).CONCLUSION The analysis of NLR and NPR are strictly correlated with Clavien-Dindo IV-V complications and 30-day post-LT death.
文摘Objective Peritoneal carcinomatosis(PC)is a common pattern of recurrence in gastric cancer patients and is associated with a poor prognosis.This study aimed to evaluate the predictive value of the albumin-fibrinogen ratio(AFR)for PC in patients with gastric cancer and to develop two preoperative prediction models.Methods A total of 745 gastric cancer patients were included in this study.Preoperative AFR,along with other serum markers and clinical tumor characteristics,was assessed.Univariate and multivariate logistic regression analyses were performed to determine the odds ratios(ORs)and 95%confidence intervals(CIs)of the independent variables.Propensity score matching(PSM)was used to control for potential confounders,and one-way ANOVA was conducted to evaluate differences in distribution between groups.Two prediction models incorporating the independent predictive indicators were constructed and validated via receiver operating characteristic(ROC)curves.Results Poorly differentiated type(OR 2.679;P=0.001),nondiffuse morphological type(OR 2.123;P=0.040),BMI<23.550 kg/m^(2)(OR 4.635;P=0.001),AFR<11.275(OR 2.895;P=0.003)and CA199≥73.615 U/mL(OR 2.040;P=0.037)were identified as independent risk factors for PC in patients with gastric cancer.After PSM,the AFR remained the only inflammatory marker that was independently associated with PC(P=0.003).AFR demonstrated consistent robustness in predicting PC across multiple sample sets.Among all the independent risk factors,the AFR had the highest area under the curve(AUC)for ROC analysis(AUC 0.648;95%CI 0.580–0.715).Two combination models incorporating the AFR demonstrated enhanced predictive ability:Combination Model 1(AUC 0.759;95%CI 0.699–0.820)and Combination Model 2(AUC 0.801;95%CI 0.744–0.859).Conclusions The preoperative AFR serves as a useful indicator for predicting PC.Two reliable prediction models based on the AFR have been developed.
基金Funded by the National Natural Science Foundation of China(No.52472012)Opening Project of State Silica-Based Materials Laboratory of Anhui Province(No.2022KF11)the Research and Development of Glass Powder for Laser Sealing and Its Sealing Technology(No.K24556)。
文摘The low-melting glass of Bi2O_(3)-B2O_(3)-SiO_(2)(BiBSi)system was used for the first time for laser sealing of vacuum glazing.Under the condition of constant boron content,how the structure and properties vary with Bi/Si ratio in low-melting glass was investigated.In addition,the relationships between laser power,low-melting glass solder with different Bi/Si ratios and laser sealing shear strength were revealed.The results show that a decrease in the Bi/Si ratio can cause a contraction of the glass network of the low-melting glass,leading to an increase of its characteristic temperature and a decrease of its coefficient of thermal expansion.During laser sealing,the copper ions in the low-melting glass play an endothermic role.A change in the Bi/Si ratio will affect the valence state transition of the copper ions in the low-melting glass.The absorbance of the low-melting glass does not follow the expected correlation with the Bi/Si ratio,but shows a linear correlation with the content of divalent copper ions.The greater the concentration of divalent copper ions,the greater the absorbance of the low-melting glass,and the lower the laser power required for laser sealing.The shear strength of the low melting glass solder after laser sealing was tested,and it was found that the maximum shear strength of Z1 glass sample was the highest up to 2.67 MPa.
基金financially supported by the CITIC niobium steel development award Fund(M1656-2021)Central Iron and Steel Research Institute for its independent research and development fund(No.21G62460ZD).
文摘Increasing the hole expansion ratio is significant for developing high formability parts.Hole expansion tests were carried out on low carbon hot-rolled steel containing 0.11%Ti,0.072%Ti–0.03%Nb and 0.097%Ti–0.059%Nb,respectively.The effects of microstructure,texture,crack propagation behavior and second phase precipitation behavior on hole expansion ratio were investigated.The precipitation behavior of TiC and(Ti,Nb)C in austenite and ferrite in three groups of steel samples was calculated theoretically.The results showed that the hole expansion ratios of 0.11Ti,0.072Ti–0.03Nb and 0.097Ti–0.059Nb test steels were 51.73%,51.17%and 66.24%following simulated coiling at 600℃,respectively.The microstructure was mainly polygonal ferrite with a small amount of pearlite.The grain refinement of 0.097Ti–0.059Nb test steel and the low texture ratio of{110}//ND improved the hole expansion ratio.The low overall hole expansion ratio was due to the microstructure inhomogeneity.The microstructure uniformity was improved by the quenching and tempering treatment,and the hole expansion ratio of the three test steels was greatly increased.The fastest precipitation temperatures in the austenitic region of 0.11Ti,0.072Ti–0.03Nb and 0.097Ti–0.059Nb test steels were 880,860 and 830℃,while those in the ferrite region were 680,675 and 675℃,respectively.The addition of Nb element increased the volume free energy,so that the critical core size of the nucleation on the dislocation line increased,resulting in the decrease in the fastest precipitation temperature.
基金supported by the National Natural Science Foundation of China (Grant Nos.12202294 and 12022208)the Project funded by China Postdoctoral Science Foundation (Grant No.2022M712243)the Fundamental Research Funds for the Central Universities (Grant No.2023SCU12098).
文摘It is well known that coarse-grained super-elastic NiTi shape memory alloys(SMAs)exhibit localized rather than homogeneous martensite transformation(MT),which,however,can be strongly influenced by either internal size(grain size,GS)or the external size(geometric size).The coupled effect of GS and geometric size on the functional properties has not been clearly understood yet.In this work,the super-elasticity,one-way,and stress-assisted two-way shape memory effects of the polycrystalline NiTi SMAs with different aspect ratios(length/width for the gauge section)and different GSs are investigated based on the phase field method.The coupled effect of the aspect ratio and GS on the functional properties is adequately revealed.The simulated results indicate that when the aspect ratio is lower than about 4:1,the stress biaxiality and stress heterogeneity in the gauge section of the sample become more and more obvious with decreasing the aspect ratio,which can significantly influence the microstructure evolution in the process involving external stress.Therefore,the corresponding functional property is strongly dependent on the aspect ratio.With decreasing the GS and the aspect ratio(to be lower than 4:1),both the aspect ratio and GS can affect the MT or martensite reorientation in each grain and the interaction among grains.Thus,due to the strong internal constraint(i.e.,the constraint of grain boundary)and the external constraint(i.e.,the constraint of geometric boundary),the capabilities of the functional properties of NiTi SMAs are gradually weakened and highly dependent on these two factors.
文摘Gastric cancer(GC)is a leading cause of cancer-related deaths,highlighting the need for reliable prognostic biomarkers to guide treatment.Wei et al’s systematic review and meta-analysis evaluates the neutrophil-to-lymphocyte ratio(NLR)as a potential biomarker for GC patients undergoing neoadjuvant chemotherapy.NLR is a simple and cost-effective measure of systemic inflammation that shows promise in predicting treatment response and survival outcomes,including overall survival and progression-free survival.However,variations in NLR thresholds and timing of measurements affect its accuracy and clinical utility.Moreover,the studies reviewed primarily involved Asian populations,which may limit the generalizability of the findings.To improve NLR’s clinical relevance,future research should focus on standardizing NLR thresholds,refining measurement timing,and incorporating additional inflammatory markers like platelet-to-lymphocyte ratio and Glasgow prognostic score.Addressing con-founders and including diverse patient populations will help improve NLR’s reliability as a prognostic marker for GC.
基金supported by the National Natural Science Foundation of China(Nos.52270106 and 22266021)Yunnan Major Scientific and Technological Projects(No.202202AG050005)Yunnan Fundamental Research Projects(No.202201AT070116).
文摘This study employed a wet impregnation method to synthesize five types of Cu/HZSM-5 adsorbents with Si/Al ratios of 25,50,85,200,and 300,used for the removal of H_(2)S in lowtemperature,low-oxygen environments.The impact of different Si/Al ratios on the adsorption oxidative performance of Cu_(30)/HZSM-5–85 adsorbents was investigated.According to the performance test results,Cu_(30)/HZSM-5–85 exhibited the highest breakthrough capacity,reaching 231.75 mg H_(2)S/g_(sorbent).Cu/HZSM-5 sorbent maintains a strong ability to remove H_(2)S even under humid conditions and shows excellent water resistance.XRD,BET,and XPS results revealed that CuO is the primary active species,with Cu_(30)/HZSM-5–85 having the largest surface area and highest CuO content,providing more active sites for H_(2)S adsorption.H_(2)-TPR and O_(2)-TPD results confirmed that Cu_(30)/HZSM-5–85 sorbent exhibits outstanding redox properties and oxygen storage capacity,contributing to excellent oxygen transferability in the molecular sieve adsorption-oxidation process.With notable characteristics such as a large surface area,high desulfurization efficiency,and water resistance,Cu_(30)/HZSM-5–85 sorbents hold significant importance for industrial applications.
文摘BACKGROUND Non-ST segment elevation myocardial infarction(NSTEMI)poses significant challenges in clinical management due to its diverse outcomes.Understanding the prognostic role of hematological parameters and derived ratios in NSTEMI patients could aid in risk stratification and improve patient care.AIM To evaluate the predictive value of hemogram-derived ratios for major adverse cardiovascular events(MACE)in NSTEMI patients,potentially improving clinical outcomes.METHODS A prospective,observational cohort study was conducted in 2021 at the Internal Medicine Clinic of the University Hospital in Tuzla,Bosnia and Herzegovina.The study included 170 patients with NSTEMI,who were divided into a group with MACE and a control group without MACE.Furthermore,the MACE group was subdivided into lethal and non-lethal groups for prognostic analysis.Alongside hematological parameters,an additional 13 hematological-derived ratios(HDRs)were monitored,and their prognostic role was investigated.RESULTS Hematological parameters did not significantly differ between non-ST segment elevation myocardial infarction(NSTEMI)patients with MACE and a control group at T1 and T2.However,significant disparities emerged in HDRs among NSTEMI patients with lethal and non-lethal outcomes post-MACE.Notably,neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)were elevated in lethal outcomes.Furthermore,C-reactive protein-to-lymphocyte ratio(CRP/Ly)at T1(>4.737)demonstrated predictive value[odds ratio(OR):3.690,P=0.024].Both NLR at T1(>4.076)and T2(>4.667)emerged as significant predictors,with NLR at T2 exhibiting the highest diagnostic performance,as indicated by an area under the curve of 0.811(95%CI:0.727-0.859)and OR of 4.915(95%CI:1.917-12.602,P=0.001),emphasizing its important role as a prognostic marker.CONCLUSION This study highlights the significant prognostic value of hemogram-derived indexes in predicting MACE among NSTEMI patients.During follow-up,NLR,PLR,and CRP/Ly offer important insights into the inflammatory processes underlying cardiovascular events.
文摘With the continuous application of new technologies in reconnaissance and attack, false camouflage plays a more important role in improving the survivability of targets, and the number of decoys plays a crucial role in the camouflaging effect. Based on the concept of cost-effectiveness ratio, according to the newly formulated Johnson criterion and the view of discovery and destruction, this paper proposes to take the identification probability as the probability of being destroyed and uses mathematical formulas to calculate the cost of a single use decoy. On this basis, a cost-effectiveness ratio model is established, with the product of the increase in the survival probability of the target and the cost of the target as the benefit, and the sum of the product of the probability of being destroyed and the cost of the decoy and the cost of a single use as the consumption cost. The model is calculated and analyzed, and the number of decoys that conform to the actual situation is obtained.
文摘BACKGROUND An efficient index holds the potential to predict rectal cancer prognosis.AIM To investigate the impact of neutrophil-to-lymphocyte ratio(NLR),platelet-tolymphocyte ratio(PLR),and monocyte-to-lymphocyte ratio(MLR)on rectal cancer prognosis.METHODS This retrospective study involved 180 patients with rectal cancer from the Changzhi People’s Hospital of Shanxi Province.A 2-mL blood sample was collected at 24 h preoperatively and 72 h postoperatively to measure neutrophils,lymphocytes,platelets,and monocytes using an automatic blood analyzer.Preoperative and postoperative NLR,PLR,and MLR were compared.Patients were followed up for 12 months and categorized into good and poor prognosis groups.A receiver operating characteristic curve was constructed to analyze their predictive values.RESULTS The NLR,PLR,and MLR values were significantly lower post-surgery(P<0.05).A total of 152 and 28 patients were categorized in the good and poor prognosis groups,respectively.Patients with poor prognoses exhibited slightly higher postoperative NLR,PLR,and MLR values than those with good prognoses(P<0.05).Receiver operating characteristic analysis showed that the area under the curve for NLR,PLR,and MLR was 0.828 with a sensitivity and specificity of 89.29%and 90.79%,respectively.These values were higher than individual NLR(area under the curve:0.660,sensitivity:67.86%,specificity:54.61%),PLR(0.668,75.00%,55.30%),and MLR(0.635,60.71%,48.03%),all showing statistically significant differences(P<0.05),effectively predicting patient outcomes.CONCLUSION The findings of this study indicated that NLR,PLR,and MLR values of patients with rectal cancer can be used to effectively predict the outcome of patients.
基金supported by the CAMS Innovation Fund for Medical Sciences(No.2021-I2M-1-008)the National High Level Hospital Clinical Research Funding(No.2023-GSP-GG-2&No.2023-GSP-QN-34&No.2023-GSPRC-05).
文摘BACKGROUND The clinical impact of post-percutaneous coronary intervention (PCI) quantitative flow ratio (QFR) in patients treated with PCI for chronic total occlusion (CTO) was still undetermined.METHODS All CTO vessels treated with successful anatomical PCI in patients from PANDA Ⅲ trial were retrospectively measured for postPCI QFR.The primary outcome was 2-year vessel-oriented composite endpoints (VOCEs,composite of target vessel-related cardiac death,target vessel-related myocardial infarction,and ischemia-driven target vessel revascularization).Receiver operator characteristic curve analysis was conducted to identify optimal cutoff value of post-PCI QFR for predicting the 2-year VOCEs,and all vessels were stratified by this optimal cutoff value.Cox proportional hazards models were employed to calculate the hazard ratio (HR) with 95% CI.RESULTS Among 428 CTO vessels treated with PCI,353 vessels (82.5%) were analyzable for post-PCI QFR.31 VOCEs (8.7%) occurred at 2 years.Mean value of post-PCI QFR was 0.92±0.13.Receiver operator characteristic curve analysis shown the optimal cutoff value of post-PCI QFR for predicting 2-year VOCEs was 0.91.The incidence of 2-year VOCEs in the vessel with post-PCI QFR<0.91 (n=91) was significantly higher compared with the vessels with post-PCI QFR≥0.91 (n=262)(22.0%vs.4.2%,HR=4.98,95%CI:2.32–10.70).CONCLUSIONS Higher post-PCI QFR values were associated with improved prognosis in the PCI practice for coronary CTO.Achieving functionally optimal PCI results (post-PCI QFR value≥0.91) tends to get better prognosis for patients with CTO lesions.
