In the context of national efforts to promote high-quality development of vocational education and deepen industry-education integration,private vocational undergraduate institutions serve as crucial platforms bridgin...In the context of national efforts to promote high-quality development of vocational education and deepen industry-education integration,private vocational undergraduate institutions serve as crucial platforms bridging the cultivation of high-level technical and skilled talents with regional industrial development.The alignment between their distinctive specialty clusters and regional industrial synergy directly impacts talent development quality and regional economic efficiency.This paper analyzes the inherent logic of coordinated development between specialty clusters and regional industries,leveraging the flexible operational mechanisms and direct industry connections of private vocational institutions.It identifies current challenges,including“inaccurate demand alignment,insufficient resource integration,and loose interest coordination,”and proposes four strategic dimensions:establishing collaborative research mechanisms,optimizing cluster layouts,deepening industry-education integration,and improving support systems.These recommendations provide actionable references for advancing high-quality coordinated development between private vocational institutions and regional industries.展开更多
Ports,the core hub of global supply chains,serve as vital links in the economic and trade exchanges among countries.Efficient,safe,green and smart ports are essential for the smooth operation of global trade.Recently,...Ports,the core hub of global supply chains,serve as vital links in the economic and trade exchanges among countries.Efficient,safe,green and smart ports are essential for the smooth operation of global trade.Recently,ISO established ISO/TC 8/SC 27,Ports and terminals,the secretariat of which is held by China.This is a big breakthrough of China’s participation in the international standardization activities in the area of transportation.展开更多
The coordinated regional development strategy,recognized as one of China’s seven development strategies,plays a crucial role in reducing regional development disparities,optimizing resource allocation,and facilitatin...The coordinated regional development strategy,recognized as one of China’s seven development strategies,plays a crucial role in reducing regional development disparities,optimizing resource allocation,and facilitating high-quality development.This study analyzes a total of 418 relevant publications from China spanning the years 1998 to 2022.Utilizing CiteSpace software,a visualization analysis of keyword cooccurrence,mutation,and other bibliometric characteristics was conducted.The findings indicate that the number of publications during the specified period exhibited a fluctuating upward trend,with a notable increase observed after 2018.Furthermore,the research demonstrated a weak interdisciplinary crossover and a low intensity of collaboration among authors.The primary thematic areas of focus were identified as follows:connotation,mechanisms,countermeasure and suggestion,and evaluation.展开更多
Agricultural insurance plays a key role in promoting the coordinated development of green agriculture and farmers’income growth,which is crucial for China’s high-quality agricultural development.Using the coupling c...Agricultural insurance plays a key role in promoting the coordinated development of green agriculture and farmers’income growth,which is crucial for China’s high-quality agricultural development.Using the coupling coordination degree model,this study empirically demonstrates that the development of agricultural insurance significantly promotes the coordinated development of green agriculture and farmers’income growth once a certain threshold is exceeded.This effect is more pronounced in the major grain-producing regions and the central provinces.Expanding the scale of agricultural production and increasing investment in agricultural technology are the key mechanisms through which agricultural insurance supports the dual goals of green agriculture and income growth in China.In conclusion,this study proposes several policy recommendations,which include increasing investment in agricultural insurance infrastructure,strengthening the policy guidance for agricultural insurance,and designing differentiated agricultural insurance policies.展开更多
The exploration of the coupling and coordination between urban innovation capability(IC)and industrial transformation(IF)serves as a novel perspective for interpreting the increasingly severe phenomenon of population ...The exploration of the coupling and coordination between urban innovation capability(IC)and industrial transformation(IF)serves as a novel perspective for interpreting the increasingly severe phenomenon of population shrinkage during the industrialization process.This study investigated the evolutionary characteristics of IC and IF in shrinking and growing cities in Northeast China from 2010 to 2020.It uses entropy weighted model,coupling coordination degree,the Dagum Gini coefficient,and geographic detectors to analyze the coordinated development of IC and IF in the context of population shrinkage.The study analyzed the spatiotemporal patterns and driving mechanisms for their coordinated development.The results show that:1)both urban IC and IF exhibited an overall positive trend during the study period.Shrinking cities depend more on IF to address the challenges of population shrinkage,while growing cities mainly rely on innovation-driven development.2)The coupling gap between IC and IF in shrinking and growing cities has widened over time,with the coordination level of shrinking cities steadily decreasing.Cities with serious disorder are concentrated in northern Heilongjiang Province,while most cities in Jilin Province experience moderate disorder.Liaoning Province,however,shows generally good coupling coordination.3)Human capital is the key factor driving coupling coordination in both types of cities.Shrinking cities rely on economic and financial development,with the‘repair-type’logic that emphasizes short-term economic growth and resource compensation.In contrast,the coupling of growing cities relies on basic support capabilities,with the‘optimization-type’logic focused on enhancing endogenous resilience and systemic coordination.Exploring the coordination between urban innovation capabilities and industrial transformation can provide a new perspective for research on population shrinkage,which holds certain theoretical and practical significance for implementing the new round of revitalization strategy in Northeast China.展开更多
China is carving out a distinctive development path which features urban-rural integration.This approach has not only yielded tangible results domestically but also drawn the attention of other countries.
China aims to build on its achievements of the past five years to accelerate rural revitalization during the 15th Five-Year Plan period.IN China,issues relating to agriculture,rural areas,and rural residents have alwa...China aims to build on its achievements of the past five years to accelerate rural revitalization during the 15th Five-Year Plan period.IN China,issues relating to agriculture,rural areas,and rural residents have always been a priority in national development.At its fourth plenary session held in October 2025,the 20th Central Committee of the Communist Party of China(CPC)once again emphasized the need to accelerate agricultural and rural modernization,and advance all-around rural revitalization over the next five years.展开更多
Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables th...Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables this dynamic is the white matter(WM),known to be affected in neurodevelopmental disorders(NDDs)(Rokach et al.,2024).WM formation is mediated by myelination,a multifactorial process driven by neuro-glia interactions dependent on proper neuronal functionality(Simons and Trajkovic,2006).Another key aspect of neurodevelopmental abnormalities involves neuronal dynamics and function,with recent advances significantly enhancing our understanding of both neuronal and glial mitochondrial function(Devine and Kittler,2018;Rojas-Charry et al.,2021).Energy homeostasis in neurons,attributed largely to mitochondrial function,is critical for proper functionality and interactions with oligodendrocytes(OLs),the cells forming myelin in the brain’s WM.We herein discuss the interplay between these processes and speculate on potential dysfunction in NDDs.展开更多
Governance debates gained strong momentum in Africa in early December 2025 as the China-Kenya Readers Forum on Xi Jinping:The Governance of China convened in Nairobi on 1 December 2025,followed by a promotional event ...Governance debates gained strong momentum in Africa in early December 2025 as the China-Kenya Readers Forum on Xi Jinping:The Governance of China convened in Nairobi on 1 December 2025,followed by a promotional event for the English edition of the book’s fifth volume on 3 December 2025 in Johannesburg,South Africa.展开更多
This study examines the methods to plan the development of offshore oilfields over the years,which are used to support the decision-making on the development of offshore oilfields.About 100 papers are analysed and cat...This study examines the methods to plan the development of offshore oilfields over the years,which are used to support the decision-making on the development of offshore oilfields.About 100 papers are analysed and categorised into different groups of main early-stage decisions.The present study stands in contrast to the contributions of the operations research and system engineering review articles,on the one hand,and the petroleum engineering review articles,on the other.This is because it does not focus on one methodological approach,nor does it limit the literature analysis by offshore oilfield characteristics.Consequently,the present analysis may offer valuable insights,for instance,by identifying environmental planning decisions as a recent yet highly significant concern that is currently being imposed on decision-making process.Thus,it is evident that the incorporation of safety criteria within the technical-economic decision-making process for the design of production systems would be a crucial requirement at development phase.展开更多
The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regul...The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulates diverse aspects of neural development and function. Genetic mutations within the m TOR pathway lead to severe neurodevelopmental disorders, collectively known as “mTORopathies”(Crino, 2020). Dysfunctions of m TOR, including both its hyperactivation and hypoactivation, have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions, highlighting its importance in CNS health.展开更多
Motor neuron diseases are sporadic or inherited fatal neurodegenerative conditions.They selectively affect the upper and/or lower motor neurons in the brain and spinal cord and feature a slow onset and a subacute cour...Motor neuron diseases are sporadic or inherited fatal neurodegenerative conditions.They selectively affect the upper and/or lower motor neurons in the brain and spinal cord and feature a slow onset and a subacute course contingent upon the site of damage.The main types include amyotrophic lateral sclerosis,progressive muscular atrophy,primary lateral sclerosis,and progressive bulbar palsy,the pathological processes of which are largely identical,with the main disparity lying in the location of the lesions.Amyotrophic lateral sclerosis is the representative condition in this group of diseases,while other types are its variants.Hence,this article mainly focuses on the advancements and challenges in drug research for amyotrophic lateral sclerosis but also briefly addresses several other important degenerative motor neuron diseases.Although the precise pathogenesis remains elusive,recent advancements have shed light on various theories,including gene mutation,excitatory amino acid toxicity,autoimmunology,and neurotrophic factors.The US Food and Drug Administration has approved four drugs for use in delaying the progression of amyotrophic lateral sclerosis:riluzole,edaravone,AMX0035,and tofersen,with the latter being the most recent to receive approval.However,following several phaseⅢtrials that failed to yield favorable outcomes,AMX0035 has been voluntarily withdrawn from both the US and Canadian markets.This article presents a comprehensive summary of drug trials primarily completed between January 1,2023,and June 30,2024,based on data sourced from clinicaltrials.gov.Among these trials,five are currently in phaseⅠ,seventeen are in phaseⅡ,and eleven are undergoing phaseⅢevaluation.Notably,24 clinical trials are now investigating potential disease-modifying therapy drugs,accounting for the majority of the drugs included in this review.Some promising drugs being investigated in preclinical studies,such as ATH-1105,are included in our analysis,and another review in frontiers in gene therapy and immunotherapy has demonstrated their therapeutic potential for motor neuron diseases.This article was written to be an overview of research trends and treatment prospects related to motor neuron disease drugs,with the aim of highlighting the latest potentialities for clinical therapy.展开更多
Oligodendrocytes and their cell-intrinsic gene regulatory network:Oligodendrocytes(OLs)are the myelinating glial cells of the vertebrate central nervous system.They are responsible for insulating neuronal axons with a...Oligodendrocytes and their cell-intrinsic gene regulatory network:Oligodendrocytes(OLs)are the myelinating glial cells of the vertebrate central nervous system.They are responsible for insulating neuronal axons with a lipid-rich myelin sheath,which enables the saltatory conduction of action potentials.During development,oligodendrocyte progenitor cells(OPCs)emerge from neural stem cells in the ventricular zone.They then proliferate,increase their number,and migrate to their final destination where they encounter unmyelinated neuronal axons and differentiate in a stepwise fashion into myelinating oligodendrocytes(mOLs)under the influence of environmental stimuli.展开更多
With the low-carbon coordinated development in Beijing-Tianjin-Hebei Region as the starting point, the necessity and realistic difficulties in achieving the lowcarbon coordination in Beijing-Tianjin-Hebei Region was a...With the low-carbon coordinated development in Beijing-Tianjin-Hebei Region as the starting point, the necessity and realistic difficulties in achieving the lowcarbon coordination in Beijing-Tianjin-Hebei Region was analyzed, based on which we constructed the systematic analytical framework for low-carbon coordination in Beijing-Tianjin-Hebei Region, and proposed the development path of regional lowcarbon coordinated development from the three levels of government, industry and consumer with the aim to provide specific references for the low-carbon coordinated development in Beijing-Tianjin-Hebei Region.展开更多
In view of China's rapid urbanization,Nanyuan Dormitory Area of Anhui Agricultural University was studied as a representative of traditional living quarters with harmonious neighborhood relationship to discuss cur...In view of China's rapid urbanization,Nanyuan Dormitory Area of Anhui Agricultural University was studied as a representative of traditional living quarters with harmonious neighborhood relationship to discuss current use and coordinated development of traditional residential districts from the perspective of human settlement.Problems in the dormitory area were analyzed,neighboring environment,regional characteristics,cultures and all relevant elements were fully considered to build a favorable human settlement by following the coordinated development of human settlement and economy.Renovation strategies on the basis of maintaining original favorable human settlement were discussed from the perspectives of space ecology,dwelling environment,facilities and humanistic environment,so as to provide new concepts for the sustainable development of urban traditional residential districts and the construction of favorable human settlement.展开更多
Rural tourism is a tourism type al owing interplay between tourists and targeted areas in rural areas. ln order to maintain coordinated development between rural tourism and local economy, with Lianyungang City as an ...Rural tourism is a tourism type al owing interplay between tourists and targeted areas in rural areas. ln order to maintain coordinated development between rural tourism and local economy, with Lianyungang City as an example, some countermeasures and suggestions were proposed, such as establishing benefit feed-back system, forging brands and ruling management system.展开更多
[Objective] To provide quantification means for comprehensively analyzing the coordinated development of urban human settlement and economy by constructing an index system of economy and human settlement. [Method] By ...[Objective] To provide quantification means for comprehensively analyzing the coordinated development of urban human settlement and economy by constructing an index system of economy and human settlement. [Method] By constructing an evaluation index system of economy and human settlement, and using the coordinate measurement model of them, 22 county-level cities in the Yellow River Basin were analyzed. [Result] In the Yellow River Basin, the construction level of economy and human settlement in those county-level cities is low with distinct spatial differences and deteriorating polarization; there is a great spatial corresponding between coordinated development degree and economic level, the higher the economic development level, the higher coordinated development degree in county-level cities; county-level cities around the boundaries of provinces have difficulties in development. [Conclusion] Evaluation standards and models are clear in significance, convenient in application, which can successfully evaluate the coordination of human settlement development in the study region.展开更多
The coordinated development of human settlement environment and economy is of vital significance to urban sustainable development and urban ecosystem health. Urban human settlement and economic systems exist in urban ...The coordinated development of human settlement environment and economy is of vital significance to urban sustainable development and urban ecosystem health. Urban human settlement and economic systems exist in urban ecosystems, which are a structural complexity. Therefore the research is being challenged by some uncertain factors between human settlements and economic systems. However most of the researches were focused on its determinate objective aspects and qualitative analyses while less concern on the quanti- tative evaluation of coordinated development of urban human settlement environment and economy, especially little on its uncertain aspect. At present, the urgent task is to study the coordinated development of urban settlement environment and economy in terms of the effect of uncertainty. This study analyzed the uncertain characteristics, which would be confronted at different stages, such as confirming the index categories, their bound values, and their construction rate, etc. According to the actual urban conditions, many construction principles based on uncertainties are put forward and an indicating system for human settlement and economic evaluation is established. Moreover, the application of fuzzy mathematics presents a new method and a calculation model for the comprehensive assessment of the coordinated development of urban human settlement environment and economy. The application of the method and model in Changsha city of China showed that the assessment results can reflect not only the overall coordination degree of the city, but also the mode of interactive mechanism between urban economic system and human settlement environment.展开更多
Suitable spatial morphology of cultivated land is a basic requirement for sustaining agricultural economic development in mountainous areas.Coordinated development efficiency of cultivated land spatial morphology and ...Suitable spatial morphology of cultivated land is a basic requirement for sustaining agricultural economic development in mountainous areas.Coordinated development efficiency of cultivated land spatial morphology and agricultural economy(CECA)is of great practical significance to measure the efficiency of cultivated land use,and thereby promote regional rural revitalization.However,few studies to date have focused on coordinated development efficiency between cultivated land use and agricultural economy in mountainous areas from the perspective of cultivated land spatial morphology.Thus,the present study explores CECA with this focus using the data envelopment analysis method,and analyzes the key influencing factors via a geographical detector model in 16 counties in western Hubei province.The results show the following:(1)CECA exhibits significant spatial heterogeneity that is high in the south of the study area and low in the north;(2)scale efficiency is the primary limiting factor for CECA;(3)the insufficient output of cultivated land use mainly restricts CECA in the south of the study area,while individual county in the north suffered from input redundancy and insufficient output;and(4)population density in the southern region has the most significant effect on CECA,and gross domestic product has the greatest impact in the northern region.The results contribute to the derivation of specific measures by which to promote cultivated land use efficiency and sustainable development of the social economy.展开更多
Based on the carrying capacity of the resources and the environment,this article defines the connotation of the land multifunctional space(LMFS)from three aspects,ecological protection,agricultural production and urba...Based on the carrying capacity of the resources and the environment,this article defines the connotation of the land multifunctional space(LMFS)from three aspects,ecological protection,agricultural production and urban construction,in the new era of land space planning system.Moreover,a framework is constructed for the coordinated development of the multi-functional oriented space to match the use of land space(ULS)with the supply of resources and environment(SRE).Based on this,the technology and methods of comprehensive evaluation,dominance recognition,and matching relationship division functions of the use of land space(FULS)and functions of the supply of resources and environment(FSRE)are discussed.The advantageous functions of the use of land space(AFULS)and advantageous functions of the supply of resources and environment(AFSRE)are also identified in the study area.A LMFS coordinated development system integrating“function position-comprehensive partition-regulation strategy”is proposed.Through the empirical study of Shandong province,we found that,first,the FULS of ecological protection space in the province is mainly found in high value areas,and the FSRE is mainly in low value areas,which has certain complementarity in the space.The FULS of agricultural production space is mainly observed in high value areas,the FSRE is mainly in middle value areas,and the spatial distribution is balanced and staggered.The FULS of the urban construction space and the FSRE are mainly in middle values areas,and the spatial distribution is basically similar.Second,the FULS in the study area is dominated by the single advantage of agricultural production and urban construction,while the FSRE has a relatively balanced distribution of the advantages of ecological protection,single agricultural production and compound advantages of agricultural production and urban construction,and urban construction and ecological protection.The matching between the two is mainly at high and middle levels.Specifically,70%of the province’s land space still has a certain development and utilization potential,and 30%of ULS intensity is close to or exceeds the resource and environment carrying capacity.Third,considering the comprehensive impact of resource endowment,social and economic development and policy and institutional environment on different matching relationships,this paper constructs the land spatial development strategic pattern of“two screens-seven regions-multicore”positioning and“four regions-eight categories”hierarchical area of Shandong at the macro level,and puts forward a differentiated land space development strategy.展开更多
基金China Private Education Association 2025 Annual Planning Topic“Research on the Construction Path of Characteristic Specialty Groups in Private Vocational Undergraduate Colleges——Dynamic Adjustment Mechanism of Specialty at Hainan Science and Technology Vocational University Based on Regional Industrial Demand”(CANQN250302)。
文摘In the context of national efforts to promote high-quality development of vocational education and deepen industry-education integration,private vocational undergraduate institutions serve as crucial platforms bridging the cultivation of high-level technical and skilled talents with regional industrial development.The alignment between their distinctive specialty clusters and regional industrial synergy directly impacts talent development quality and regional economic efficiency.This paper analyzes the inherent logic of coordinated development between specialty clusters and regional industries,leveraging the flexible operational mechanisms and direct industry connections of private vocational institutions.It identifies current challenges,including“inaccurate demand alignment,insufficient resource integration,and loose interest coordination,”and proposes four strategic dimensions:establishing collaborative research mechanisms,optimizing cluster layouts,deepening industry-education integration,and improving support systems.These recommendations provide actionable references for advancing high-quality coordinated development between private vocational institutions and regional industries.
文摘Ports,the core hub of global supply chains,serve as vital links in the economic and trade exchanges among countries.Efficient,safe,green and smart ports are essential for the smooth operation of global trade.Recently,ISO established ISO/TC 8/SC 27,Ports and terminals,the secretariat of which is held by China.This is a big breakthrough of China’s participation in the international standardization activities in the area of transportation.
文摘The coordinated regional development strategy,recognized as one of China’s seven development strategies,plays a crucial role in reducing regional development disparities,optimizing resource allocation,and facilitating high-quality development.This study analyzes a total of 418 relevant publications from China spanning the years 1998 to 2022.Utilizing CiteSpace software,a visualization analysis of keyword cooccurrence,mutation,and other bibliometric characteristics was conducted.The findings indicate that the number of publications during the specified period exhibited a fluctuating upward trend,with a notable increase observed after 2018.Furthermore,the research demonstrated a weak interdisciplinary crossover and a low intensity of collaboration among authors.The primary thematic areas of focus were identified as follows:connotation,mechanisms,countermeasure and suggestion,and evaluation.
基金This paper presents preliminary research findings from two projects:a major project funded by the National Social Science Fund of China,titled“Changes in the Nature of Rural Poverty in China in the New Era and Research on Post-2020 Anti-Poverty Policies”(Project No:19ZDA116)Doctoral Research Project under the Special Program for Talents in Shortage Areas Serving National Needs,Nanjing University of Finance and Economics,titled“The Impact of Policy-Based Agricultural Insurance on Farmers’Income and Welfare Levels”(Project No:BSZX2021-12).
文摘Agricultural insurance plays a key role in promoting the coordinated development of green agriculture and farmers’income growth,which is crucial for China’s high-quality agricultural development.Using the coupling coordination degree model,this study empirically demonstrates that the development of agricultural insurance significantly promotes the coordinated development of green agriculture and farmers’income growth once a certain threshold is exceeded.This effect is more pronounced in the major grain-producing regions and the central provinces.Expanding the scale of agricultural production and increasing investment in agricultural technology are the key mechanisms through which agricultural insurance supports the dual goals of green agriculture and income growth in China.In conclusion,this study proposes several policy recommendations,which include increasing investment in agricultural insurance infrastructure,strengthening the policy guidance for agricultural insurance,and designing differentiated agricultural insurance policies.
基金Under the auspices of National Natural Science Foundation of China(No.42471227,42171198)。
文摘The exploration of the coupling and coordination between urban innovation capability(IC)and industrial transformation(IF)serves as a novel perspective for interpreting the increasingly severe phenomenon of population shrinkage during the industrialization process.This study investigated the evolutionary characteristics of IC and IF in shrinking and growing cities in Northeast China from 2010 to 2020.It uses entropy weighted model,coupling coordination degree,the Dagum Gini coefficient,and geographic detectors to analyze the coordinated development of IC and IF in the context of population shrinkage.The study analyzed the spatiotemporal patterns and driving mechanisms for their coordinated development.The results show that:1)both urban IC and IF exhibited an overall positive trend during the study period.Shrinking cities depend more on IF to address the challenges of population shrinkage,while growing cities mainly rely on innovation-driven development.2)The coupling gap between IC and IF in shrinking and growing cities has widened over time,with the coordination level of shrinking cities steadily decreasing.Cities with serious disorder are concentrated in northern Heilongjiang Province,while most cities in Jilin Province experience moderate disorder.Liaoning Province,however,shows generally good coupling coordination.3)Human capital is the key factor driving coupling coordination in both types of cities.Shrinking cities rely on economic and financial development,with the‘repair-type’logic that emphasizes short-term economic growth and resource compensation.In contrast,the coupling of growing cities relies on basic support capabilities,with the‘optimization-type’logic focused on enhancing endogenous resilience and systemic coordination.Exploring the coordination between urban innovation capabilities and industrial transformation can provide a new perspective for research on population shrinkage,which holds certain theoretical and practical significance for implementing the new round of revitalization strategy in Northeast China.
文摘China is carving out a distinctive development path which features urban-rural integration.This approach has not only yielded tangible results domestically but also drawn the attention of other countries.
文摘China aims to build on its achievements of the past five years to accelerate rural revitalization during the 15th Five-Year Plan period.IN China,issues relating to agriculture,rural areas,and rural residents have always been a priority in national development.At its fourth plenary session held in October 2025,the 20th Central Committee of the Communist Party of China(CPC)once again emphasized the need to accelerate agricultural and rural modernization,and advance all-around rural revitalization over the next five years.
文摘Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables this dynamic is the white matter(WM),known to be affected in neurodevelopmental disorders(NDDs)(Rokach et al.,2024).WM formation is mediated by myelination,a multifactorial process driven by neuro-glia interactions dependent on proper neuronal functionality(Simons and Trajkovic,2006).Another key aspect of neurodevelopmental abnormalities involves neuronal dynamics and function,with recent advances significantly enhancing our understanding of both neuronal and glial mitochondrial function(Devine and Kittler,2018;Rojas-Charry et al.,2021).Energy homeostasis in neurons,attributed largely to mitochondrial function,is critical for proper functionality and interactions with oligodendrocytes(OLs),the cells forming myelin in the brain’s WM.We herein discuss the interplay between these processes and speculate on potential dysfunction in NDDs.
文摘Governance debates gained strong momentum in Africa in early December 2025 as the China-Kenya Readers Forum on Xi Jinping:The Governance of China convened in Nairobi on 1 December 2025,followed by a promotional event for the English edition of the book’s fifth volume on 3 December 2025 in Johannesburg,South Africa.
基金the Strategic Research Plan of the Centre for Marine Technology and Ocean Engineering(CENTEC),which is financed by the Portuguese Foundation for Science and Technology(Fundação para a Ciência e a Tecnologia FCT)under contract UIDB/UIDP/00134/2020.
文摘This study examines the methods to plan the development of offshore oilfields over the years,which are used to support the decision-making on the development of offshore oilfields.About 100 papers are analysed and categorised into different groups of main early-stage decisions.The present study stands in contrast to the contributions of the operations research and system engineering review articles,on the one hand,and the petroleum engineering review articles,on the other.This is because it does not focus on one methodological approach,nor does it limit the literature analysis by offshore oilfield characteristics.Consequently,the present analysis may offer valuable insights,for instance,by identifying environmental planning decisions as a recent yet highly significant concern that is currently being imposed on decision-making process.Thus,it is evident that the incorporation of safety criteria within the technical-economic decision-making process for the design of production systems would be a crucial requirement at development phase.
基金supported by grants from Simons Foundation (SFARI 479754),CIHR (PJT-180565)the Scottish Rite Charitable Foundation of Canada (to YL)funding from the Canada Research Chairs program。
文摘The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulates diverse aspects of neural development and function. Genetic mutations within the m TOR pathway lead to severe neurodevelopmental disorders, collectively known as “mTORopathies”(Crino, 2020). Dysfunctions of m TOR, including both its hyperactivation and hypoactivation, have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions, highlighting its importance in CNS health.
基金supported by the National Key Research and Development Program of China,No.2022YFC2703101(to YC)the National Natural Science Fundation of China,No.82371422(to YC)+1 种基金the National Innovation and Entrepreneurship Training Program for College Students,No.202310611408(to XW)the 1·3·5 Project for Disciplines of Excellence Clinical Research Fund,West China Hospital,Sichuan University,No.2023HXFH032(to YC)。
文摘Motor neuron diseases are sporadic or inherited fatal neurodegenerative conditions.They selectively affect the upper and/or lower motor neurons in the brain and spinal cord and feature a slow onset and a subacute course contingent upon the site of damage.The main types include amyotrophic lateral sclerosis,progressive muscular atrophy,primary lateral sclerosis,and progressive bulbar palsy,the pathological processes of which are largely identical,with the main disparity lying in the location of the lesions.Amyotrophic lateral sclerosis is the representative condition in this group of diseases,while other types are its variants.Hence,this article mainly focuses on the advancements and challenges in drug research for amyotrophic lateral sclerosis but also briefly addresses several other important degenerative motor neuron diseases.Although the precise pathogenesis remains elusive,recent advancements have shed light on various theories,including gene mutation,excitatory amino acid toxicity,autoimmunology,and neurotrophic factors.The US Food and Drug Administration has approved four drugs for use in delaying the progression of amyotrophic lateral sclerosis:riluzole,edaravone,AMX0035,and tofersen,with the latter being the most recent to receive approval.However,following several phaseⅢtrials that failed to yield favorable outcomes,AMX0035 has been voluntarily withdrawn from both the US and Canadian markets.This article presents a comprehensive summary of drug trials primarily completed between January 1,2023,and June 30,2024,based on data sourced from clinicaltrials.gov.Among these trials,five are currently in phaseⅠ,seventeen are in phaseⅡ,and eleven are undergoing phaseⅢevaluation.Notably,24 clinical trials are now investigating potential disease-modifying therapy drugs,accounting for the majority of the drugs included in this review.Some promising drugs being investigated in preclinical studies,such as ATH-1105,are included in our analysis,and another review in frontiers in gene therapy and immunotherapy has demonstrated their therapeutic potential for motor neuron diseases.This article was written to be an overview of research trends and treatment prospects related to motor neuron disease drugs,with the aim of highlighting the latest potentialities for clinical therapy.
基金supported by grants from the Deutsche Forschungsgemeinschaft(DFG)to MW.
文摘Oligodendrocytes and their cell-intrinsic gene regulatory network:Oligodendrocytes(OLs)are the myelinating glial cells of the vertebrate central nervous system.They are responsible for insulating neuronal axons with a lipid-rich myelin sheath,which enables the saltatory conduction of action potentials.During development,oligodendrocyte progenitor cells(OPCs)emerge from neural stem cells in the ventricular zone.They then proliferate,increase their number,and migrate to their final destination where they encounter unmyelinated neuronal axons and differentiate in a stepwise fashion into myelinating oligodendrocytes(mOLs)under the influence of environmental stimuli.
基金Study on the Coordinated Innovation of Agricultural Knowledge Under the Perspective of Industrial Chain,One of the Periodical Achievements of Strategic Research Program for the Science and Technology Development of Tianjin City(15ZLZLZF00210)Study on the Evolution Path and Scientific and Technological Supporting System of Agriculture of Appropriate Scale Based on Heterogeneous Farmers,One of the Periodical Achievements of Strategic Research Program for the Science and Technology Development of Tianjin City(15ZLZLZF00390)~~
文摘With the low-carbon coordinated development in Beijing-Tianjin-Hebei Region as the starting point, the necessity and realistic difficulties in achieving the lowcarbon coordination in Beijing-Tianjin-Hebei Region was analyzed, based on which we constructed the systematic analytical framework for low-carbon coordination in Beijing-Tianjin-Hebei Region, and proposed the development path of regional lowcarbon coordinated development from the three levels of government, industry and consumer with the aim to provide specific references for the low-carbon coordinated development in Beijing-Tianjin-Hebei Region.
文摘In view of China's rapid urbanization,Nanyuan Dormitory Area of Anhui Agricultural University was studied as a representative of traditional living quarters with harmonious neighborhood relationship to discuss current use and coordinated development of traditional residential districts from the perspective of human settlement.Problems in the dormitory area were analyzed,neighboring environment,regional characteristics,cultures and all relevant elements were fully considered to build a favorable human settlement by following the coordinated development of human settlement and economy.Renovation strategies on the basis of maintaining original favorable human settlement were discussed from the perspectives of space ecology,dwelling environment,facilities and humanistic environment,so as to provide new concepts for the sustainable development of urban traditional residential districts and the construction of favorable human settlement.
基金Supported by Philosophy and Social Science Research in Jiangsu Colleges and Universities(2011SJD630027)Leader Cultivation Program of Colleges and Universities of Jiangsu Province~~
文摘Rural tourism is a tourism type al owing interplay between tourists and targeted areas in rural areas. ln order to maintain coordinated development between rural tourism and local economy, with Lianyungang City as an example, some countermeasures and suggestions were proposed, such as establishing benefit feed-back system, forging brands and ruling management system.
基金Supported by Special S & T Fundamental Project"Investigation on the Situation and Changes of Human Activity Laws and Human Settlement in Northern China and Neighboring Regions (SB2007FY110300)~~
文摘[Objective] To provide quantification means for comprehensively analyzing the coordinated development of urban human settlement and economy by constructing an index system of economy and human settlement. [Method] By constructing an evaluation index system of economy and human settlement, and using the coordinate measurement model of them, 22 county-level cities in the Yellow River Basin were analyzed. [Result] In the Yellow River Basin, the construction level of economy and human settlement in those county-level cities is low with distinct spatial differences and deteriorating polarization; there is a great spatial corresponding between coordinated development degree and economic level, the higher the economic development level, the higher coordinated development degree in county-level cities; county-level cities around the boundaries of provinces have difficulties in development. [Conclusion] Evaluation standards and models are clear in significance, convenient in application, which can successfully evaluate the coordination of human settlement development in the study region.
基金Humanities and Social Science Foundation of Ministry of Education of PRC, No.11YJCZH201 Natural Science Foundation of Hunan Province, No.10JJ5017+1 种基金 Social Science Foundation of Hunan Province, No.2010JD19 No.09YBA003
文摘The coordinated development of human settlement environment and economy is of vital significance to urban sustainable development and urban ecosystem health. Urban human settlement and economic systems exist in urban ecosystems, which are a structural complexity. Therefore the research is being challenged by some uncertain factors between human settlements and economic systems. However most of the researches were focused on its determinate objective aspects and qualitative analyses while less concern on the quanti- tative evaluation of coordinated development of urban human settlement environment and economy, especially little on its uncertain aspect. At present, the urgent task is to study the coordinated development of urban settlement environment and economy in terms of the effect of uncertainty. This study analyzed the uncertain characteristics, which would be confronted at different stages, such as confirming the index categories, their bound values, and their construction rate, etc. According to the actual urban conditions, many construction principles based on uncertainties are put forward and an indicating system for human settlement and economic evaluation is established. Moreover, the application of fuzzy mathematics presents a new method and a calculation model for the comprehensive assessment of the coordinated development of urban human settlement environment and economy. The application of the method and model in Changsha city of China showed that the assessment results can reflect not only the overall coordination degree of the city, but also the mode of interactive mechanism between urban economic system and human settlement environment.
基金National Natural Science Foundation of China,No.71804168。
文摘Suitable spatial morphology of cultivated land is a basic requirement for sustaining agricultural economic development in mountainous areas.Coordinated development efficiency of cultivated land spatial morphology and agricultural economy(CECA)is of great practical significance to measure the efficiency of cultivated land use,and thereby promote regional rural revitalization.However,few studies to date have focused on coordinated development efficiency between cultivated land use and agricultural economy in mountainous areas from the perspective of cultivated land spatial morphology.Thus,the present study explores CECA with this focus using the data envelopment analysis method,and analyzes the key influencing factors via a geographical detector model in 16 counties in western Hubei province.The results show the following:(1)CECA exhibits significant spatial heterogeneity that is high in the south of the study area and low in the north;(2)scale efficiency is the primary limiting factor for CECA;(3)the insufficient output of cultivated land use mainly restricts CECA in the south of the study area,while individual county in the north suffered from input redundancy and insufficient output;and(4)population density in the southern region has the most significant effect on CECA,and gross domestic product has the greatest impact in the northern region.The results contribute to the derivation of specific measures by which to promote cultivated land use efficiency and sustainable development of the social economy.
基金National Natural Science Foundation of China,No.42077434,No.41771560Shandong Provincial Institutions of Higher Learning“Youth Innovation Team Development Plan”Project,No.2019RWG016。
文摘Based on the carrying capacity of the resources and the environment,this article defines the connotation of the land multifunctional space(LMFS)from three aspects,ecological protection,agricultural production and urban construction,in the new era of land space planning system.Moreover,a framework is constructed for the coordinated development of the multi-functional oriented space to match the use of land space(ULS)with the supply of resources and environment(SRE).Based on this,the technology and methods of comprehensive evaluation,dominance recognition,and matching relationship division functions of the use of land space(FULS)and functions of the supply of resources and environment(FSRE)are discussed.The advantageous functions of the use of land space(AFULS)and advantageous functions of the supply of resources and environment(AFSRE)are also identified in the study area.A LMFS coordinated development system integrating“function position-comprehensive partition-regulation strategy”is proposed.Through the empirical study of Shandong province,we found that,first,the FULS of ecological protection space in the province is mainly found in high value areas,and the FSRE is mainly in low value areas,which has certain complementarity in the space.The FULS of agricultural production space is mainly observed in high value areas,the FSRE is mainly in middle value areas,and the spatial distribution is balanced and staggered.The FULS of the urban construction space and the FSRE are mainly in middle values areas,and the spatial distribution is basically similar.Second,the FULS in the study area is dominated by the single advantage of agricultural production and urban construction,while the FSRE has a relatively balanced distribution of the advantages of ecological protection,single agricultural production and compound advantages of agricultural production and urban construction,and urban construction and ecological protection.The matching between the two is mainly at high and middle levels.Specifically,70%of the province’s land space still has a certain development and utilization potential,and 30%of ULS intensity is close to or exceeds the resource and environment carrying capacity.Third,considering the comprehensive impact of resource endowment,social and economic development and policy and institutional environment on different matching relationships,this paper constructs the land spatial development strategic pattern of“two screens-seven regions-multicore”positioning and“four regions-eight categories”hierarchical area of Shandong at the macro level,and puts forward a differentiated land space development strategy.
