Objective This study aimed to investigate possible serum 25-hydroxyvitamin D[25(OH)D]cutoffs for the associations between 25(OH)D and Bone turnover markers(BTMs),and how GC gene variation influences such cutoffs in Ch...Objective This study aimed to investigate possible serum 25-hydroxyvitamin D[25(OH)D]cutoffs for the associations between 25(OH)D and Bone turnover markers(BTMs),and how GC gene variation influences such cutoffs in Chinese women of childbearing age.Methods In total,1,505 non-pregnant or non-lactating women(18–45 years)were recruited from the 2015 Chinese Adult Chronic Disease and Nutrition Surveillance.Serum 25(OH)D,osteocalcin(OC),procollagen type 1 N-terminal propeptide(P1NP),β-CrossLaps of type 1 collagen containing cross-linked C-telopeptide(β-CTX),and single nucleotide polymorphisms were determined.Locally weighted regression and smoothing scatterplot and segmented regression were performed to estimate the 25(OH)D thresholds.Results The median serum 25(OH)D was 16.63(11.96–22.55)ng/mL and the prevalence of low serum 25(OH)D(<12 ng/mL)was 25.2%.Women with the lowest 25(OH)D had the highestβ-CTX.After adjustment for the confounders,25(OH)D cutoffs for OC[14.04(12.84–15.23)ng/mL],β-CTX[13.94(12.49–15.39)ng/mL],and P1NP[13.87(12.37–15.37)ng/mL]in the whole population,cutoffs for OC[12.30(10.68–13.91)ng/mL],β-CTX[12.23(10.22–14.23)ng/mL],and P1NP[11.85(10.40–13.31)ng/mL]in women with the GC rs2282679 G allele,and cutoffs for OC[12.75(11.81–13.68)ng/mL],β-CTX[13.05(11.78–14.32)ng/mL],and P1NP[12.81(11.57–14.06)ng/mL]in women with the GC rs2282679 T allele,were observed.Below these cutoffs,BTMs were negatively associated with 25(OH)D,while above these cutoffs,BTMs plateaued.Conclusion In Chinese women of childbearing age,there were thresholds effect of serum 25(OH)D concentrations on BTMs.The results indicated that serum 25(OH)D concentrations<13.87 ng/mL in this population had adverse influences on maintaining bone remodeling.BTMs were suppressed at a relatively lower serum 25(OH)D in women with the GC rs2282679 G allele compared with those with the T allele.展开更多
Seedling quality is important for subtropical tree species endangered by the degradation of natural habitats in southern China.At present,the cultural regime for raising these seedlings involving fertilizer levels and...Seedling quality is important for subtropical tree species endangered by the degradation of natural habitats in southern China.At present,the cultural regime for raising these seedlings involving fertilizer levels and size of container is not clear.In this study,seedlings of three endangered species,red-seed tree(Ormosia hosiei),Zhejiang phoebe(Phoebe chekian gensis),and Zhejiang camphor(Cinnamomum japonicum)were evaluated along with red-bark oak(Cyclobalanopsis gilva)as a reference,a species which is not endangered.Seedlings were raised in 2.8,3.6,5.1,and 6.3 L containers and fertilizer applied at 1.0,2.0,3.0 and 4.0 kg m-3.Seedling height and leaf biomass increased in response to higher fertilizer levels while larger containers resulted in greater stem and root biomass.Root biomass of endangered species seedlings did not respond to neither treatments.Zhejiang phoebe seedlings responded to nitrogen and phosphorus uptake but red-seed tree seedlings were unaffected by any nutrient levels.Red-bark oak seedlings had high nitrogen-use efficiency.Based on the results,it is recommended using at least 5.1 L containers to culture Zhejiang phoebe and Zhejiang camphor seedlings with fertilizer at 3.0 kg m-3.Red-bark oak and red-seed tree seedlings should be cultured with 2.0 kg m-3 in smaller containers.展开更多
A series of new Schiff base type macrocyclic crown ethers containing naphthalene ring were synthesized from 2,2'-di(o-formylnaphthoxy) ethyl ether or 1,2-di(o-formylnaphthoxy) ethane and four appropriate diamines....A series of new Schiff base type macrocyclic crown ethers containing naphthalene ring were synthesized from 2,2'-di(o-formylnaphthoxy) ethyl ether or 1,2-di(o-formylnaphthoxy) ethane and four appropriate diamines. The chemical structures of the new compounds were characterized by elemental analysis, infrared spectra, nuclear magnetic resonance spectra and mass spectrometry.展开更多
基金funded by the National Natural Science Foundation of China(No.81872627and No.82473611)the National Financial Projects ‘Assessment and Application of Nutrients Requirement and Food Environment for Chinese Residents’(No.102393220020070000013)。
文摘Objective This study aimed to investigate possible serum 25-hydroxyvitamin D[25(OH)D]cutoffs for the associations between 25(OH)D and Bone turnover markers(BTMs),and how GC gene variation influences such cutoffs in Chinese women of childbearing age.Methods In total,1,505 non-pregnant or non-lactating women(18–45 years)were recruited from the 2015 Chinese Adult Chronic Disease and Nutrition Surveillance.Serum 25(OH)D,osteocalcin(OC),procollagen type 1 N-terminal propeptide(P1NP),β-CrossLaps of type 1 collagen containing cross-linked C-telopeptide(β-CTX),and single nucleotide polymorphisms were determined.Locally weighted regression and smoothing scatterplot and segmented regression were performed to estimate the 25(OH)D thresholds.Results The median serum 25(OH)D was 16.63(11.96–22.55)ng/mL and the prevalence of low serum 25(OH)D(<12 ng/mL)was 25.2%.Women with the lowest 25(OH)D had the highestβ-CTX.After adjustment for the confounders,25(OH)D cutoffs for OC[14.04(12.84–15.23)ng/mL],β-CTX[13.94(12.49–15.39)ng/mL],and P1NP[13.87(12.37–15.37)ng/mL]in the whole population,cutoffs for OC[12.30(10.68–13.91)ng/mL],β-CTX[12.23(10.22–14.23)ng/mL],and P1NP[11.85(10.40–13.31)ng/mL]in women with the GC rs2282679 G allele,and cutoffs for OC[12.75(11.81–13.68)ng/mL],β-CTX[13.05(11.78–14.32)ng/mL],and P1NP[12.81(11.57–14.06)ng/mL]in women with the GC rs2282679 T allele,were observed.Below these cutoffs,BTMs were negatively associated with 25(OH)D,while above these cutoffs,BTMs plateaued.Conclusion In Chinese women of childbearing age,there were thresholds effect of serum 25(OH)D concentrations on BTMs.The results indicated that serum 25(OH)D concentrations<13.87 ng/mL in this population had adverse influences on maintaining bone remodeling.BTMs were suppressed at a relatively lower serum 25(OH)D in women with the GC rs2282679 G allele compared with those with the T allele.
基金This work was supported by“Forestry Science and Technology Cooperation Project between Zhejiang Province and Chinese Academy of Forestry(2017SY19)”“Fundamental Research Funds of CAF”(CAFYBB2018GC003).
文摘Seedling quality is important for subtropical tree species endangered by the degradation of natural habitats in southern China.At present,the cultural regime for raising these seedlings involving fertilizer levels and size of container is not clear.In this study,seedlings of three endangered species,red-seed tree(Ormosia hosiei),Zhejiang phoebe(Phoebe chekian gensis),and Zhejiang camphor(Cinnamomum japonicum)were evaluated along with red-bark oak(Cyclobalanopsis gilva)as a reference,a species which is not endangered.Seedlings were raised in 2.8,3.6,5.1,and 6.3 L containers and fertilizer applied at 1.0,2.0,3.0 and 4.0 kg m-3.Seedling height and leaf biomass increased in response to higher fertilizer levels while larger containers resulted in greater stem and root biomass.Root biomass of endangered species seedlings did not respond to neither treatments.Zhejiang phoebe seedlings responded to nitrogen and phosphorus uptake but red-seed tree seedlings were unaffected by any nutrient levels.Red-bark oak seedlings had high nitrogen-use efficiency.Based on the results,it is recommended using at least 5.1 L containers to culture Zhejiang phoebe and Zhejiang camphor seedlings with fertilizer at 3.0 kg m-3.Red-bark oak and red-seed tree seedlings should be cultured with 2.0 kg m-3 in smaller containers.
文摘A series of new Schiff base type macrocyclic crown ethers containing naphthalene ring were synthesized from 2,2'-di(o-formylnaphthoxy) ethyl ether or 1,2-di(o-formylnaphthoxy) ethane and four appropriate diamines. The chemical structures of the new compounds were characterized by elemental analysis, infrared spectra, nuclear magnetic resonance spectra and mass spectrometry.
