Three-dimensional(3D)printing is a highly automated platform that facilitates material deposition in a layer-by-layer approach to fabricate pre-defined 3D complex structures on demand.It is a highly promising techniqu...Three-dimensional(3D)printing is a highly automated platform that facilitates material deposition in a layer-by-layer approach to fabricate pre-defined 3D complex structures on demand.It is a highly promising technique for the fabrication of personalized medical devices or even patient-specific tissue constructs.Each type of 3D printing technique has its unique advantages and limitations,and the selection of a suitable 3D printing technique is highly dependent on its intended application.In this review paper,we present and highlight some of the critical processes(printing parameters,build orientation,build location,and support structures),material(batch-to-batch consistency,recycling,protein adsorption,biocompatibility,and degradation properties),and regulatory considerations(sterility and mechanical properties)for 3D printing of personalized medical devices.The goal of this review paper is to provide the readers with a good understanding of the various key considerations(process,material,and regulatory)in 3D printing,which are critical for the fabrication of improved patient-specific 3D printed medical devices and tissue constructs.展开更多
Three-dimensional(3D)printing technology has opened a new paradigm to controllably and reproducibly fabricate bioengineered neural constructs for potential applications in repairing injured nervous tissues or producin...Three-dimensional(3D)printing technology has opened a new paradigm to controllably and reproducibly fabricate bioengineered neural constructs for potential applications in repairing injured nervous tissues or producing in vitro nervous tissue models.However,the complexity of nervous tissues poses great challenges to 3D-printed bioengineered analogues,which should possess diverse architectural/chemical/electrical functionalities to resemble the native growth microenvironments for functional neural regeneration.In this work,we provide a state-of-the-art review of the latest development of 3D printing for bioengineered neural constructs.Various 3D printing techniques for neural tissue-engineered scaffolds or living cell-laden constructs are summarized and compared in terms of their unique advantages.We highlight the advanced strategies by integrating topographical,biochemical and electroactive cues inside 3D-printed neural constructs to replicate in vivo-like microenvironment for functional neural regeneration.The typical applications of 3D-printed bioengineered constructs for in vivo repair of injured nervous tissues,bio-electronics interfacing with native nervous system,neural-on-chips as well as brain-like tissue models are demonstrated.The challenges and future outlook associated with 3D printing for functional neural constructs in various categories are discussed.展开更多
The optimization approach based on the biological evolution principle is used to con-struct the heat transport paths for volume-to-point problem. The transport paths are constructed by inserting high conductivity mate...The optimization approach based on the biological evolution principle is used to con-struct the heat transport paths for volume-to-point problem. The transport paths are constructed by inserting high conductivity materials in the heat conduction domain where uniform or nonuniform heat sources exist. In the bionic optimization process, the optimal constructs of the high conductiv-ity material are obtained by numerically simulating the evolution and degeneration process ac-cording to the uniformity principle of the temperature gradient. Finally, preserving the features of the optimal constructs, the constructs are regularized for the convenience of engineering manu-facture. The results show that the construct obtained by bionic optimization is approximate to that obtained by the tree-network constructal theory when the heat conduction is enhanced for the do-main with a uniform heat source and high conductivity ratio of the inserting material to the sub-strate, the high conductivity materials are mainly concentrated on the heat outlet for the case with a uniform heat source and low thermal conductivity ratio, and for the case with nonuniform heat sources, the high conductivity material is concentrated in the heat source regions and construacts several highly effective heat transport paths to connect the regions to the outlet.展开更多
Bioprinting is a rapidly developing technology for the precise design and manufacture of tissues in various biological systems or organs.Coaxial extrusion bioprinting,an emergent branch,has demonstrated a strong poten...Bioprinting is a rapidly developing technology for the precise design and manufacture of tissues in various biological systems or organs.Coaxial extrusion bioprinting,an emergent branch,has demonstrated a strong potential to enhance bioprinting's engineering versatility.Coaxial bioprinting assists in the fabrication of complex tissue constructs,by enabling concentric deposition of biomaterials.The fabricated tissue constructs started with simple,tubular vasculature but have been substantially developed to integrate complex cell composition and self-assembly,ECM patterning,controlled release,and multi-material gradient profiles.This review article begins with a brief overview of coaxial printing history,followed by an introduction of crucial engineering components.Afterward,we review the recent progress and untapped potential in each specific organ or biological system,and demonstrate how coaxial bioprinting facilitates the creation of tissue constructs.Ultimately,we conclude that this growing technology will contribute significantly to capabilities in the fields of in vitro modeling,pharmaceutical development,and clinical regenerative medicine.展开更多
The ready-to-use,structure-supporting hydrogel bioink can shorten the time for ink preparation,ensure cell dispersion,and maintain the preset shape/microstructure without additional assistance during printing.Meanwhil...The ready-to-use,structure-supporting hydrogel bioink can shorten the time for ink preparation,ensure cell dispersion,and maintain the preset shape/microstructure without additional assistance during printing.Meanwhile,ink with high permeability might facilitate uniform cell growth in biological constructs,which is beneficial to homogeneous tissue repair.Unfortunately,current bioinks are hard to meet these requirements simultaneously in a simple way.Here,based on the fast dynamic crosslinking of aldehyde hyaluronic acid(AHA)/N-carboxymethyl chitosan(CMC)and the slow stable crosslinking of gelatin(GEL)/4-arm poly(ethylene glycol)succinimidyl glutarate(PEG-SG),we present a time-sharing structure-supporting(TSHSP)hydrogel bioink with high permeability,containing 1%AHA,0.75%CMC,1%GEL and 0.5%PEG-SG.The TSHSP hydrogel can facilitate printing with proper viscoelastic property and self-healing behavior.By crosslinking with 4%PEG-SG for only 3 min,the integrity of the cell-laden construct can last for 21 days due to the stable internal and external GEL/PEG-SG networks,and cells manifested long-term viability and spreading morphology.Nerve-like,muscle-like,and cartilage-like in vitro constructs exhibited homogeneous cell growth and remarkable biological specificities.This work provides not only a convenient and practical bioink for tissue engineering,targeted cell therapy,but also a new direction for hydrogel bioink development.展开更多
Extensive burns and full-thickness skin wounds are difficult to repair. Autologous split-thickness skin graft (ASSG) is still used as the gold standard in the clinic. However, the shortage of donor skin tissues is a s...Extensive burns and full-thickness skin wounds are difficult to repair. Autologous split-thickness skin graft (ASSG) is still used as the gold standard in the clinic. However, the shortage of donor skin tissues is a serious problem. A potential solution to this problem is to fabricate skin constructs using biomaterial scaffolds with or without cells. Bioprinting is being applied to address the need for skin tissues suitable for transplantation, and can lead to the development of skin equivalents for wound healing therapy. Here, we summarize strategies of bioprinting and review current advances of bioprinting of skin constructs. There will be challenges on the way of 3D bioprinting for skin regeneration, but we still believe bioprinting will be potential skills for wounds healing in the foreseeable future.展开更多
In this paper, the concretely both reflective and coreflective subconstructs of the construct CFTSof Chang fuzzy topological spaces are characterized and their relationship to such subconstructs of stratifiedfuzzy top...In this paper, the concretely both reflective and coreflective subconstructs of the construct CFTSof Chang fuzzy topological spaces are characterized and their relationship to such subconstructs of stratifiedfuzzy topological spaces is investigated. Properties of a particular such subconstruct of CFTS, the constructof weak fuzzy neighborhood spaces, are discussed in detail. And it is proved that there exists exactly c suchsubconstructs between the subconstruct of weakly induced spaces and CFTS.展开更多
Our long-term objective is to develop a software toolbox for pre-embodiment design of complex and heterogeneous systems, such as cyber-physical systems. The novelty of this toolbox is that it uses system manifestation...Our long-term objective is to develop a software toolbox for pre-embodiment design of complex and heterogeneous systems, such as cyber-physical systems. The novelty of this toolbox is that it uses system manifestation features(SMFs) for transdisciplinary modeling of these systems. The main challenges of implementation of the toolbox are functional design- and language-independent computational realization of the warehouses, and systematic development and management of the various evolving implements of SMFs(genotypes, phenotypes, and instances). Therefore, an information schema construct(ISC) based approach is proposed to create the schemata of the associated warehouse databases and the above-mentioned SMF implements. ISCs logically arrange the data contents of SMFs in a set of relational tables of varying semantics. In this article we present the ISCs necessary for creation of genotypes and phenotypes. They increase the efficiency of the database development process and make the data relationships transparent. Our follow-up research focuses on the elaboration of the SMF instances based system modeling methodology.展开更多
Complementing our previous publications, this paper presents the information schema constructs （ISCs） that underpin the programming of specific system manifestation feature （SMF） orientated information management ...Complementing our previous publications, this paper presents the information schema constructs （ISCs） that underpin the programming of specific system manifestation feature （SMF） orientated information management and composing system models. First, we briefly present （1） the general process of pre-embodiment design with SMFs, （2） the procedures of creating genotypes and phenotypes of SMFs, （3） the specific procedure of instantiation of phenotypes of SMFs, and （4） the procedure of system model management and processing. Then, the chunks of information needed for instantiation of phenotypes of SMFs are discussed, and the ISCs designed for instantiation presented. Afterwards, the information management aspects of system modeling are addressed. Methodologically, system modeling involves （1） placement of phenotypes of SMF in the modeling space, （2） combining them towards the desired architecture and operation, （3） assigning values to the parameters and checking the satisfac- tion of constraints, and （4） storing the system model in the SMFs-based warehouse database. The final objective of the reported research is to develop an SMFs-based toolbox to support modeling of cyber-physical systems （CPSs）.展开更多
East Africa’s construction boom draws Chinese heavy machinery manufacturers and distributors The booming construction of new housing and commercial units has led to unprecedented demand for heavy construction equipme...East Africa’s construction boom draws Chinese heavy machinery manufacturers and distributors The booming construction of new housing and commercial units has led to unprecedented demand for heavy construction equipment in Nairobi,Kenya.展开更多
At the World Economic Forum Annual Meeting 2026 in Davos,China emerged as a steadfast advocate for multilateral cooperation and constructive dialogue,presenting a clear alternative to divisive rhetoric.CHINA’S role a...At the World Economic Forum Annual Meeting 2026 in Davos,China emerged as a steadfast advocate for multilateral cooperation and constructive dialogue,presenting a clear alternative to divisive rhetoric.CHINA’S role as a key player in shaping global development and trends stood out at the World Economic Forum(WEF)annual meeting 2026 in Davos,Switzerland.展开更多
[Objectives]To explore the control mode of farmland drainage pollutants and investigate the effects of ecological ditch and wetland on reducing farmland drainage pollutants in Hetao Irrigation District.[Methods]Based ...[Objectives]To explore the control mode of farmland drainage pollutants and investigate the effects of ecological ditch and wetland on reducing farmland drainage pollutants in Hetao Irrigation District.[Methods]Based on the demonstration construction project of the ecological ditch-constructed wetland system in the Hetao Irrigation District,an experimental study was conducted from July to September 2023 to investigate the interception and purification effects of ecological ditches,constructed wetlands,and the combined ecological ditch-constructed wetland system on farmland drainage pollutants.Key water quality parameters measured included total nitrogen(TN)concentration and total phosphorus(TP)concentration.[Results]Different treatment modes of ecological ditches and constructed wetlands have a certain removal effect on nitrogen and phosphorus pollutants in water bodies.The ecological ditches treated with Astragalus laxmannii,Melilotus officinalis,Medicago sativa,bio-ball substrate,and bio-sheet substrate showed reduction efficiencies for TN and TP of 21.09% and 23.84%,12.06% and 26.67%,20.08% and 34.15%,23.65% and 20.56%,and 19.92% and 25.83%,respectively.The emergent plant area showed reduction efficiencies of 24.28%for TN and 17.89%for TP,while the submerged plant area achieved a reduction efficiency of 10.21%for both TN and TP.Among the different treatment modes,the ecological ditch with M.sativa performed better in TP removal,whereas the bio-ball substrate treatment mode showed higher effectiveness in TN removal.In addition,the emergent plant area exhibited better TP removal performance,while the submerged plant area was more effective in TN removal.The combined system of ecological ditch and constructed wetland achieved removal rates of 37.55% for TN and 11.47% for TP.It effectively facilitates the step-by-step interception and adsorption purification of pollutants,thereby showing significant removal and purification effects on nitrogen and phosphorus contaminants.This contributes to mitigating agricultural non-point source pollution.[Conclusions]The combined ecological ditch-constructed wetland system serves dual functions of agricultural drainage and pollutant interception and purification.It reduces the pollution load of farmland drainage on receiving water bodies to some extent and mitigates agricultural non-point source pollution.Therefore,it is a relatively suitable technology for managing agricultural non-point source pollution in the Hetao Irrigation District.展开更多
Fluorinated motifs are prevalent in both pharmaceuticals and agrochemicals.The incorporation of fluorine-containing moieties to drug candidates has emerged as a potent strategy for lead optimization in pharmaceutical ...Fluorinated motifs are prevalent in both pharmaceuticals and agrochemicals.The incorporation of fluorine-containing moieties to drug candidates has emerged as a potent strategy for lead optimization in pharmaceutical research and development.While extensive research has been devoted to constructing molecules that incorporate a trifluoromethylthio(SCF_(3)−)group on a stereogenic carbon,the synthesis of trifluoromethylthiolated alkanes featuring a SCF_(3)-substituted stereogenic carbon at non-activated site remains understudied.Herein,we report a Cu-catalyzed regio-and enantioselective hydroallylation of 1-trifluoromethylthiolated alkenes.Important to the process is the regio-and enantioselective Cu-H insertion to SCF_(3)-substituted alkene to form chiralα-SCF_(3) alkyl copper intermediates,outcompeting unproductive insertion to the coupling partner,and eventually proceed to afford optically active homoallylic trifluoromethylthiolated products.展开更多
The historical image of Ouyang Xiu constructed during the Song Dynasty evolved from a multifaceted portrayal that balanced his political and literary achievements into a singular cultural symbol.In the Northern Song D...The historical image of Ouyang Xiu constructed during the Song Dynasty evolved from a multifaceted portrayal that balanced his political and literary achievements into a singular cultural symbol.In the Northern Song Dynasty,writings by Ouyang Xiu's family and epitaphs by his colleagues crafted a balanced narrative emphasizing both his official duties and literary merits,thus constructing a dual image of him as a principled remonstrator and a literary master.In the Southern Song Dynasty,official historiography gradually eroded his complex persona as a political reformer by selectively trimming political disputes and emphasizing his literary lineage,ultimately establishing him as a cultural exemplar beyond factional strife.Throughout this evolution of historical writing,Ouyang Xiu's sharpness as a remonstrator was gradually obscured in historical texts,while his image as a literary master,revered by all,became firmly established.The reshaping of Ouyang Xiu's image in historical writings across the Northern and Southern Song dynasties not only reflects the logic of selecting scholar-official role models under the influence of official ideology but also reveals the inherent pattern whereby individual distinctiveness fades into symbolic construction in historical writing.展开更多
As blockchain technology rapidly evolves,smart contracts have seen widespread adoption in financial transactions and beyond.However,the growing prevalence of malicious Ponzi scheme contracts presents serious security ...As blockchain technology rapidly evolves,smart contracts have seen widespread adoption in financial transactions and beyond.However,the growing prevalence of malicious Ponzi scheme contracts presents serious security threats to blockchain ecosystems.Although numerous detection techniques have been proposed,existing methods suffer from significant limitations,such as class imbalance and insufficient modeling of transaction-related semantic features.To address these challenges,this paper proposes an oversampling-based detection framework for Ponzi smart contracts.We enhance the Adaptive Synthetic Sampling(ADASYN)algorithm by incorporating sample proximity to decision boundaries and ensuring realistic sample distributions.This enhancement facilitates the generation of high-quality minority class samples and effectively mitigates class imbalance.In addition,we design a Contract Transaction Graph(CTG)construction algorithm to preserve key transactional semantics through feature extraction from contract code.A graph neural network(GNN)is then applied for classification.This study employs a publicly available dataset from the XBlock platform,consisting of 318 verified Ponzi contracts and 6498 benign contracts.Sourced from real Ethereum deployments,the dataset reflects diverse application scenarios and captures the varied characteristics of Ponzi schemes.Experimental results demonstrate that our approach achieves an accuracy of 96%,a recall of 92%,and an F1-score of 94%in detecting Ponzi contracts,outperforming state-of-the-art methods.展开更多
Against the backdrop of continuous social development and growing public health demands,the efficiency and scientific nature of the emergency care system are of paramount importance.This paper focuses on researching t...Against the backdrop of continuous social development and growing public health demands,the efficiency and scientific nature of the emergency care system are of paramount importance.This paper focuses on researching the construction of an emergency care system based on the concept of“linkage”,delving into its theoretical foundations,exploring innovative construction models,and analyzing practical cases.The study indicates that an emergency care system under the“linkage”concept can effectively integrate resources and enhance efficiency,providing new insights for improving the construction of the emergency care system.It aims to promote the development of the emergency care system towards a more scientific,efficient,and collaborative direction.展开更多
The distinctive landscape of Zhujiayu Ancient Village in Zhangqiu District,Ji’nan,together with its long-established cultural traditions,has shaped a unique vernacular settlement character,within which traditional dw...The distinctive landscape of Zhujiayu Ancient Village in Zhangqiu District,Ji’nan,together with its long-established cultural traditions,has shaped a unique vernacular settlement character,within which traditional dwellings serve as a primary medium of regional culture.This study examines the residence of Zhu Fengyin,a jinshi degree holder,and adopts field investigation and measured drawing-based analysis.Discussion is organized around three dimensions:an overview of the dwelling,architectural form,and cultural expression.Particular attention is given to the multi-stage,multi-bay compound configuration developed in a mountainous setting,terrain-adaptive courtyard forms,and construction techniques.The analysis further interprets the concepts of ritual order and auspicious symbolism embedded in architectural decoration.By using this representative case,the study aims to deepen understanding of the architectural culture of gentry dwellings in the Ji’nan region and to provide an academic basis for the conservation and inheritance of traditional dwellings in the Ji’nan area.展开更多
Long-life pavement has been introduced to address the urgent need for durable and reliable transportation infrastructure.This review overviews the development of aggregates for long-life pavements and summarizes futur...Long-life pavement has been introduced to address the urgent need for durable and reliable transportation infrastructure.This review overviews the development of aggregates for long-life pavements and summarizes future research directions.The review indicates that natural aggregates,being non-renewable resources,are steadily declining in availability and may need to meet future demands.Construction solid waste aggregates are rapidly developing,with fine separation of reclaimed asphalt pavement(RAP)and reinforcement of cementbased recycled aggregates serving as key strategies to enhance their application.Industry solid waste aggregates possess properties suitable for long-life pavements and offer additional functionalities such as cooling,conductivity,and reflectivity,demonstrating significant development potential.While artificial aggregates exhibit superior performance,their large-scale application requires consideration of economic and environmental impacts.Current aggregate evaluation methods need to address the needs of long-life pavements.Aggregate performance requirements should be graded based on mechanical stress and temperature distribution,with corresponding evaluation methods and indices developed.Evaluating the mechanical properties of aggregates should align more closely with actual stress states.Tests such as triaxial,repeated load,and wheel abrasion polishing are better suited for assessing the strength and durability of long-life pavement aggregates.Similarly,evaluating aggregates'physicochemical properties should be based on studies correlating these properties with road performance,with proposed evaluation criteria.Morphological characteristics of aggregates significantly influence asphalt mixture performance,and efficient evaluation of their profile,angularity,and texture will be a key focus of future research.展开更多
This study investigated the impact of the xu-argument-based continuation on Chinese high school students’English syntactic complexity captured using verb-argument constructions(VACs)over an 8-week period.Participants...This study investigated the impact of the xu-argument-based continuation on Chinese high school students’English syntactic complexity captured using verb-argument constructions(VACs)over an 8-week period.Participants were two comparable groups of students:one group worked with English input texts(i.e.,E-E),while the other worked with Chinese input texts with the same content(i.e.,C-E).The results showed that over time,the E-E group exhibited a greater tendency to use a wider range of VACs,such as caused-motion constructions,attributives,passives,and phrasal verbs.At the same time,they reduced their use of simpler VACs like intransitive-motion and simple transitive constructions,especially when compared to the C-E group.This pattern was also evident in the topic-based writing during the posttest.These findings strongly support the effectiveness of xu-argument-based continuation tasks in promoting the development of L2 VAC knowledge.They suggest that tasks combining language input with output can significantly enhance learners’ability to use more sophisticated VACs.展开更多
To advance intelligent construction,standards must come first.The Ministry of Housing and Urban-Rural Development has issued the List for Replicable Experience and Practices for Developing Intelligent Construction fou...To advance intelligent construction,standards must come first.The Ministry of Housing and Urban-Rural Development has issued the List for Replicable Experience and Practices for Developing Intelligent Construction four times successively and the Technical Guidelines for Intelligent Construction(Trial).展开更多
文摘Three-dimensional(3D)printing is a highly automated platform that facilitates material deposition in a layer-by-layer approach to fabricate pre-defined 3D complex structures on demand.It is a highly promising technique for the fabrication of personalized medical devices or even patient-specific tissue constructs.Each type of 3D printing technique has its unique advantages and limitations,and the selection of a suitable 3D printing technique is highly dependent on its intended application.In this review paper,we present and highlight some of the critical processes(printing parameters,build orientation,build location,and support structures),material(batch-to-batch consistency,recycling,protein adsorption,biocompatibility,and degradation properties),and regulatory considerations(sterility and mechanical properties)for 3D printing of personalized medical devices.The goal of this review paper is to provide the readers with a good understanding of the various key considerations(process,material,and regulatory)in 3D printing,which are critical for the fabrication of improved patient-specific 3D printed medical devices and tissue constructs.
基金financially supported by the National Natural Science Foundation of China (52125501)OPEN Project (BHJ17C019)+4 种基金the Key Research Project of Shaanxi Province (2021LLRH-08)the Program for Innovation Team of Shaanxi Province (2023-CX-TD-17)the Natural Science Basic Research Program of Shaanxi Province (2023-JCQN-0543)the China Postdoctoral Science Foundation (2021M702597)the Fundamental Research Funds for the Central Universities
文摘Three-dimensional(3D)printing technology has opened a new paradigm to controllably and reproducibly fabricate bioengineered neural constructs for potential applications in repairing injured nervous tissues or producing in vitro nervous tissue models.However,the complexity of nervous tissues poses great challenges to 3D-printed bioengineered analogues,which should possess diverse architectural/chemical/electrical functionalities to resemble the native growth microenvironments for functional neural regeneration.In this work,we provide a state-of-the-art review of the latest development of 3D printing for bioengineered neural constructs.Various 3D printing techniques for neural tissue-engineered scaffolds or living cell-laden constructs are summarized and compared in terms of their unique advantages.We highlight the advanced strategies by integrating topographical,biochemical and electroactive cues inside 3D-printed neural constructs to replicate in vivo-like microenvironment for functional neural regeneration.The typical applications of 3D-printed bioengineered constructs for in vivo repair of injured nervous tissues,bio-electronics interfacing with native nervous system,neural-on-chips as well as brain-like tissue models are demonstrated.The challenges and future outlook associated with 3D printing for functional neural constructs in various categories are discussed.
基金This work was supported by the National Key Fundamental R&D Program of China (Grant No. G20000263).
文摘The optimization approach based on the biological evolution principle is used to con-struct the heat transport paths for volume-to-point problem. The transport paths are constructed by inserting high conductivity materials in the heat conduction domain where uniform or nonuniform heat sources exist. In the bionic optimization process, the optimal constructs of the high conductiv-ity material are obtained by numerically simulating the evolution and degeneration process ac-cording to the uniformity principle of the temperature gradient. Finally, preserving the features of the optimal constructs, the constructs are regularized for the convenience of engineering manu-facture. The results show that the construct obtained by bionic optimization is approximate to that obtained by the tree-network constructal theory when the heat conduction is enhanced for the do-main with a uniform heat source and high conductivity ratio of the inserting material to the sub-strate, the high conductivity materials are mainly concentrated on the heat outlet for the case with a uniform heat source and low thermal conductivity ratio, and for the case with nonuniform heat sources, the high conductivity material is concentrated in the heat source regions and construacts several highly effective heat transport paths to connect the regions to the outlet.
基金We thank Utah State University's College of Engineering Undergraduate Research Program(EURP)for supporting Andrew Kjar and Bailey McFarland.
文摘Bioprinting is a rapidly developing technology for the precise design and manufacture of tissues in various biological systems or organs.Coaxial extrusion bioprinting,an emergent branch,has demonstrated a strong potential to enhance bioprinting's engineering versatility.Coaxial bioprinting assists in the fabrication of complex tissue constructs,by enabling concentric deposition of biomaterials.The fabricated tissue constructs started with simple,tubular vasculature but have been substantially developed to integrate complex cell composition and self-assembly,ECM patterning,controlled release,and multi-material gradient profiles.This review article begins with a brief overview of coaxial printing history,followed by an introduction of crucial engineering components.Afterward,we review the recent progress and untapped potential in each specific organ or biological system,and demonstrate how coaxial bioprinting facilitates the creation of tissue constructs.Ultimately,we conclude that this growing technology will contribute significantly to capabilities in the fields of in vitro modeling,pharmaceutical development,and clinical regenerative medicine.
基金This work was supported by the National Natural Science Foundation of China[grant number 52075285]the Science and Technology Program of Guangzhou,China[grant number 201604040002]+1 种基金the Key-Area Research and Development Program of Guangdong Province,China[grant number 2020B090923003]the Key Research and Development Projects of People’s Liberation Army,China[grant number.BWS17J036].
文摘The ready-to-use,structure-supporting hydrogel bioink can shorten the time for ink preparation,ensure cell dispersion,and maintain the preset shape/microstructure without additional assistance during printing.Meanwhile,ink with high permeability might facilitate uniform cell growth in biological constructs,which is beneficial to homogeneous tissue repair.Unfortunately,current bioinks are hard to meet these requirements simultaneously in a simple way.Here,based on the fast dynamic crosslinking of aldehyde hyaluronic acid(AHA)/N-carboxymethyl chitosan(CMC)and the slow stable crosslinking of gelatin(GEL)/4-arm poly(ethylene glycol)succinimidyl glutarate(PEG-SG),we present a time-sharing structure-supporting(TSHSP)hydrogel bioink with high permeability,containing 1%AHA,0.75%CMC,1%GEL and 0.5%PEG-SG.The TSHSP hydrogel can facilitate printing with proper viscoelastic property and self-healing behavior.By crosslinking with 4%PEG-SG for only 3 min,the integrity of the cell-laden construct can last for 21 days due to the stable internal and external GEL/PEG-SG networks,and cells manifested long-term viability and spreading morphology.Nerve-like,muscle-like,and cartilage-like in vitro constructs exhibited homogeneous cell growth and remarkable biological specificities.This work provides not only a convenient and practical bioink for tissue engineering,targeted cell therapy,but also a new direction for hydrogel bioink development.
基金grants from Administration of Traditional Chinese Medicine of Sichuan(A2016N48)National Natural Science Foundation of China(81171780)+4 种基金Foundation for Distinguished Young Scientists of Sichuan Province(2016JQ0020)Project sub topics of the National 863 Project(2015AA020303)Scientific research fund for outstanding young scholars of Sichuan University(2014SCU04A12)Sichuan province science and technology support plan(2015SZ0049)Science and technology support program of Sichuan Province(2015FZ0040).
文摘Extensive burns and full-thickness skin wounds are difficult to repair. Autologous split-thickness skin graft (ASSG) is still used as the gold standard in the clinic. However, the shortage of donor skin tissues is a serious problem. A potential solution to this problem is to fabricate skin constructs using biomaterial scaffolds with or without cells. Bioprinting is being applied to address the need for skin tissues suitable for transplantation, and can lead to the development of skin equivalents for wound healing therapy. Here, we summarize strategies of bioprinting and review current advances of bioprinting of skin constructs. There will be challenges on the way of 3D bioprinting for skin regeneration, but we still believe bioprinting will be potential skills for wounds healing in the foreseeable future.
基金This work was supported by the National Natural Science Foundation of China,Fok Ying Tung Education foundation and the ScienceTechnology Foundation of Sichuan Province for Young Scholars.
文摘In this paper, the concretely both reflective and coreflective subconstructs of the construct CFTSof Chang fuzzy topological spaces are characterized and their relationship to such subconstructs of stratifiedfuzzy topological spaces is investigated. Properties of a particular such subconstruct of CFTS, the constructof weak fuzzy neighborhood spaces, are discussed in detail. And it is proved that there exists exactly c suchsubconstructs between the subconstruct of weakly induced spaces and CFTS.
文摘Our long-term objective is to develop a software toolbox for pre-embodiment design of complex and heterogeneous systems, such as cyber-physical systems. The novelty of this toolbox is that it uses system manifestation features(SMFs) for transdisciplinary modeling of these systems. The main challenges of implementation of the toolbox are functional design- and language-independent computational realization of the warehouses, and systematic development and management of the various evolving implements of SMFs(genotypes, phenotypes, and instances). Therefore, an information schema construct(ISC) based approach is proposed to create the schemata of the associated warehouse databases and the above-mentioned SMF implements. ISCs logically arrange the data contents of SMFs in a set of relational tables of varying semantics. In this article we present the ISCs necessary for creation of genotypes and phenotypes. They increase the efficiency of the database development process and make the data relationships transparent. Our follow-up research focuses on the elaboration of the SMF instances based system modeling methodology.
文摘Complementing our previous publications, this paper presents the information schema constructs （ISCs） that underpin the programming of specific system manifestation feature （SMF） orientated information management and composing system models. First, we briefly present （1） the general process of pre-embodiment design with SMFs, （2） the procedures of creating genotypes and phenotypes of SMFs, （3） the specific procedure of instantiation of phenotypes of SMFs, and （4） the procedure of system model management and processing. Then, the chunks of information needed for instantiation of phenotypes of SMFs are discussed, and the ISCs designed for instantiation presented. Afterwards, the information management aspects of system modeling are addressed. Methodologically, system modeling involves （1） placement of phenotypes of SMF in the modeling space, （2） combining them towards the desired architecture and operation, （3） assigning values to the parameters and checking the satisfac- tion of constraints, and （4） storing the system model in the SMFs-based warehouse database. The final objective of the reported research is to develop an SMFs-based toolbox to support modeling of cyber-physical systems （CPSs）.
文摘East Africa’s construction boom draws Chinese heavy machinery manufacturers and distributors The booming construction of new housing and commercial units has led to unprecedented demand for heavy construction equipment in Nairobi,Kenya.
文摘At the World Economic Forum Annual Meeting 2026 in Davos,China emerged as a steadfast advocate for multilateral cooperation and constructive dialogue,presenting a clear alternative to divisive rhetoric.CHINA’S role as a key player in shaping global development and trends stood out at the World Economic Forum(WEF)annual meeting 2026 in Davos,Switzerland.
基金Supported by Special Fund Project for the Transformation of Scientific and Technological Achievements in Inner Mongolia Autonomous Region(2021CG0013)Bayannur City Science and Technology Plan Project(K202014)+1 种基金Inner Mongolia Autonomous Region Science and Technology Plan Project(2022YFHH0088)Research Special Project of the Education Department of Inner Mongolia Autonomous Region(STAQZX202320).
文摘[Objectives]To explore the control mode of farmland drainage pollutants and investigate the effects of ecological ditch and wetland on reducing farmland drainage pollutants in Hetao Irrigation District.[Methods]Based on the demonstration construction project of the ecological ditch-constructed wetland system in the Hetao Irrigation District,an experimental study was conducted from July to September 2023 to investigate the interception and purification effects of ecological ditches,constructed wetlands,and the combined ecological ditch-constructed wetland system on farmland drainage pollutants.Key water quality parameters measured included total nitrogen(TN)concentration and total phosphorus(TP)concentration.[Results]Different treatment modes of ecological ditches and constructed wetlands have a certain removal effect on nitrogen and phosphorus pollutants in water bodies.The ecological ditches treated with Astragalus laxmannii,Melilotus officinalis,Medicago sativa,bio-ball substrate,and bio-sheet substrate showed reduction efficiencies for TN and TP of 21.09% and 23.84%,12.06% and 26.67%,20.08% and 34.15%,23.65% and 20.56%,and 19.92% and 25.83%,respectively.The emergent plant area showed reduction efficiencies of 24.28%for TN and 17.89%for TP,while the submerged plant area achieved a reduction efficiency of 10.21%for both TN and TP.Among the different treatment modes,the ecological ditch with M.sativa performed better in TP removal,whereas the bio-ball substrate treatment mode showed higher effectiveness in TN removal.In addition,the emergent plant area exhibited better TP removal performance,while the submerged plant area was more effective in TN removal.The combined system of ecological ditch and constructed wetland achieved removal rates of 37.55% for TN and 11.47% for TP.It effectively facilitates the step-by-step interception and adsorption purification of pollutants,thereby showing significant removal and purification effects on nitrogen and phosphorus contaminants.This contributes to mitigating agricultural non-point source pollution.[Conclusions]The combined ecological ditch-constructed wetland system serves dual functions of agricultural drainage and pollutant interception and purification.It reduces the pollution load of farmland drainage on receiving water bodies to some extent and mitigates agricultural non-point source pollution.Therefore,it is a relatively suitable technology for managing agricultural non-point source pollution in the Hetao Irrigation District.
基金the National Key R&D Program of China(No.2021YFF0701700)the National Natural Science Foundation of China(Nos.22271264 and 21971228)for financial support.
文摘Fluorinated motifs are prevalent in both pharmaceuticals and agrochemicals.The incorporation of fluorine-containing moieties to drug candidates has emerged as a potent strategy for lead optimization in pharmaceutical research and development.While extensive research has been devoted to constructing molecules that incorporate a trifluoromethylthio(SCF_(3)−)group on a stereogenic carbon,the synthesis of trifluoromethylthiolated alkanes featuring a SCF_(3)-substituted stereogenic carbon at non-activated site remains understudied.Herein,we report a Cu-catalyzed regio-and enantioselective hydroallylation of 1-trifluoromethylthiolated alkenes.Important to the process is the regio-and enantioselective Cu-H insertion to SCF_(3)-substituted alkene to form chiralα-SCF_(3) alkyl copper intermediates,outcompeting unproductive insertion to the coupling partner,and eventually proceed to afford optically active homoallylic trifluoromethylthiolated products.
基金an initial outcome of the Research on the Interactive Relationship Between Biographies and Epitaphs in Ancient China,a project(ID:24BZW023)supported by the National Social Science Fund of China。
文摘The historical image of Ouyang Xiu constructed during the Song Dynasty evolved from a multifaceted portrayal that balanced his political and literary achievements into a singular cultural symbol.In the Northern Song Dynasty,writings by Ouyang Xiu's family and epitaphs by his colleagues crafted a balanced narrative emphasizing both his official duties and literary merits,thus constructing a dual image of him as a principled remonstrator and a literary master.In the Southern Song Dynasty,official historiography gradually eroded his complex persona as a political reformer by selectively trimming political disputes and emphasizing his literary lineage,ultimately establishing him as a cultural exemplar beyond factional strife.Throughout this evolution of historical writing,Ouyang Xiu's sharpness as a remonstrator was gradually obscured in historical texts,while his image as a literary master,revered by all,became firmly established.The reshaping of Ouyang Xiu's image in historical writings across the Northern and Southern Song dynasties not only reflects the logic of selecting scholar-official role models under the influence of official ideology but also reveals the inherent pattern whereby individual distinctiveness fades into symbolic construction in historical writing.
基金supported by the Key Project of Joint Fund of the National Natural Science Foundation of China“Research on Key Technologies and Demonstration Applications for Trusted and Secure Data Circulation and Trading”(U24A20241)the National Natural Science Foundation of China“Research on Trusted Theories and Key Technologies of Data Security Trading Based on Blockchain”(62202118)+4 种基金the Major Scientific and Technological Special Project of Guizhou Province([2024]014)Scientific and Technological Research Projects from the Guizhou Education Department(Qian jiao ji[2023]003)the Hundred-Level Innovative Talent Project of the Guizhou Provincial Science and Technology Department(Qiankehe Platform Talent-GCC[2023]018)the Major Project of Guizhou Province“Research and Application of Key Technologies for Trusted Large Models Oriented to Public Big Data”(Qiankehe Major Project[2024]003)the Guizhou Province Computational Power Network Security Protection Science and Technology Innovation Talent Team(Qiankehe Talent CXTD[2025]029).
文摘As blockchain technology rapidly evolves,smart contracts have seen widespread adoption in financial transactions and beyond.However,the growing prevalence of malicious Ponzi scheme contracts presents serious security threats to blockchain ecosystems.Although numerous detection techniques have been proposed,existing methods suffer from significant limitations,such as class imbalance and insufficient modeling of transaction-related semantic features.To address these challenges,this paper proposes an oversampling-based detection framework for Ponzi smart contracts.We enhance the Adaptive Synthetic Sampling(ADASYN)algorithm by incorporating sample proximity to decision boundaries and ensuring realistic sample distributions.This enhancement facilitates the generation of high-quality minority class samples and effectively mitigates class imbalance.In addition,we design a Contract Transaction Graph(CTG)construction algorithm to preserve key transactional semantics through feature extraction from contract code.A graph neural network(GNN)is then applied for classification.This study employs a publicly available dataset from the XBlock platform,consisting of 318 verified Ponzi contracts and 6498 benign contracts.Sourced from real Ethereum deployments,the dataset reflects diverse application scenarios and captures the varied characteristics of Ponzi schemes.Experimental results demonstrate that our approach achieves an accuracy of 96%,a recall of 92%,and an F1-score of 94%in detecting Ponzi contracts,outperforming state-of-the-art methods.
文摘Against the backdrop of continuous social development and growing public health demands,the efficiency and scientific nature of the emergency care system are of paramount importance.This paper focuses on researching the construction of an emergency care system based on the concept of“linkage”,delving into its theoretical foundations,exploring innovative construction models,and analyzing practical cases.The study indicates that an emergency care system under the“linkage”concept can effectively integrate resources and enhance efficiency,providing new insights for improving the construction of the emergency care system.It aims to promote the development of the emergency care system towards a more scientific,efficient,and collaborative direction.
基金Major Project of the National Social Science Foundation of China“Historical Collation and Research of Cultural Exchanges Between Chinese and Foreign Craftsmen Along the Silk Road”(Approval No.22&ZD227)the Planning Project of Shaanxi Art Institute“Research on National Cultural Park Design”(Project No.YG2025001)part of the phased outcomes of the“Shaanxi Special Support Program for High-Level Talents”(Project Approval No.21HH02).
文摘The distinctive landscape of Zhujiayu Ancient Village in Zhangqiu District,Ji’nan,together with its long-established cultural traditions,has shaped a unique vernacular settlement character,within which traditional dwellings serve as a primary medium of regional culture.This study examines the residence of Zhu Fengyin,a jinshi degree holder,and adopts field investigation and measured drawing-based analysis.Discussion is organized around three dimensions:an overview of the dwelling,architectural form,and cultural expression.Particular attention is given to the multi-stage,multi-bay compound configuration developed in a mountainous setting,terrain-adaptive courtyard forms,and construction techniques.The analysis further interprets the concepts of ritual order and auspicious symbolism embedded in architectural decoration.By using this representative case,the study aims to deepen understanding of the architectural culture of gentry dwellings in the Ji’nan region and to provide an academic basis for the conservation and inheritance of traditional dwellings in the Ji’nan area.
基金sponsored by the National Natural Science Foundation of China(52178420,52408476)Research Project of Liaoning Provincial Transportation Construction Investment Group Co.,Ltd.(202410)+1 种基金Postdoctoral Fellowship Program of CPSF(GZC20242207)the Fundamental Research Funds for the Central Universities(HIT.DZJJ.2023086).
文摘Long-life pavement has been introduced to address the urgent need for durable and reliable transportation infrastructure.This review overviews the development of aggregates for long-life pavements and summarizes future research directions.The review indicates that natural aggregates,being non-renewable resources,are steadily declining in availability and may need to meet future demands.Construction solid waste aggregates are rapidly developing,with fine separation of reclaimed asphalt pavement(RAP)and reinforcement of cementbased recycled aggregates serving as key strategies to enhance their application.Industry solid waste aggregates possess properties suitable for long-life pavements and offer additional functionalities such as cooling,conductivity,and reflectivity,demonstrating significant development potential.While artificial aggregates exhibit superior performance,their large-scale application requires consideration of economic and environmental impacts.Current aggregate evaluation methods need to address the needs of long-life pavements.Aggregate performance requirements should be graded based on mechanical stress and temperature distribution,with corresponding evaluation methods and indices developed.Evaluating the mechanical properties of aggregates should align more closely with actual stress states.Tests such as triaxial,repeated load,and wheel abrasion polishing are better suited for assessing the strength and durability of long-life pavement aggregates.Similarly,evaluating aggregates'physicochemical properties should be based on studies correlating these properties with road performance,with proposed evaluation criteria.Morphological characteristics of aggregates significantly influence asphalt mixture performance,and efficient evaluation of their profile,angularity,and texture will be a key focus of future research.
文摘This study investigated the impact of the xu-argument-based continuation on Chinese high school students’English syntactic complexity captured using verb-argument constructions(VACs)over an 8-week period.Participants were two comparable groups of students:one group worked with English input texts(i.e.,E-E),while the other worked with Chinese input texts with the same content(i.e.,C-E).The results showed that over time,the E-E group exhibited a greater tendency to use a wider range of VACs,such as caused-motion constructions,attributives,passives,and phrasal verbs.At the same time,they reduced their use of simpler VACs like intransitive-motion and simple transitive constructions,especially when compared to the C-E group.This pattern was also evident in the topic-based writing during the posttest.These findings strongly support the effectiveness of xu-argument-based continuation tasks in promoting the development of L2 VAC knowledge.They suggest that tasks combining language input with output can significantly enhance learners’ability to use more sophisticated VACs.
文摘To advance intelligent construction,standards must come first.The Ministry of Housing and Urban-Rural Development has issued the List for Replicable Experience and Practices for Developing Intelligent Construction four times successively and the Technical Guidelines for Intelligent Construction(Trial).
