Through analyzing problems in the planning of green space system in cities of China,strategies for constructing urban green space system are put forward based on the requirements of conservation-oriented landscape.
The rapidly aging population directly contributes to the increasing cases of neurological disorders.Due to the chronic progressive nature of neurodegeneration,numerous neurological conditions are considered“multifact...The rapidly aging population directly contributes to the increasing cases of neurological disorders.Due to the chronic progressive nature of neurodegeneration,numerous neurological conditions are considered“multifactorial”with systemic metabolic alterations.Even so,treatments for neurological disorders have remained unchanged for the past decades.Recently,metabolic drugs such as metformin and glucagon-like peptide 1 agonists have demonstrated promising health outcomes for neurodegeneration.展开更多
With the progress of urbanization,urban landscape design has garnered increasing attention.Urban landscape design can not only reflect the construction level of a city but also has the functions of beautifying the urb...With the progress of urbanization,urban landscape design has garnered increasing attention.Urban landscape design can not only reflect the construction level of a city but also has the functions of beautifying the urban environment and enhancing the city image.Modern art enriches the expression forms of urban landscape design,and its integration with urban landscape design can greatly improve the urban landscape.This article elaborated on the connotations of modern art and urban landscape design and analyzed the application of modern art in urban landscape design.The application of modern art can help to achieve the goal of urban landscape design to the maximum extent.展开更多
In the context of rural revitalization,the landscape design of public spaces in Enshi Xiaomaopoying Village presents both new opportunities and challenges.This study explores the significance of integrating regional c...In the context of rural revitalization,the landscape design of public spaces in Enshi Xiaomaopoying Village presents both new opportunities and challenges.This study explores the significance of integrating regional culture into rural public spaces.Field research has been conducted to assess the current utilization of regional culture in the public spaces of Xiaomaopoying Village.Subsequently,design optimization strategies are analyzed and proposed.Additionally,the practical application of regional cultural elements is examined,in order to offer guidance for the application of cultural creation of traditional characteristic villages in rural public spaces.展开更多
In recent years,rapid urbanization has had a profound impact on landscape stability.As a typical example of China's rapid urbanization,Hangzhou has also experienced significant landscape changes,which have profoun...In recent years,rapid urbanization has had a profound impact on landscape stability.As a typical example of China's rapid urbanization,Hangzhou has also experienced significant landscape changes,which have profoundly affected its ecological stability.Taking Hangzhou as an example,this study integrates land use change data from 1980 to 2020,combines dynamic simulation and ecological modeling techniques,and carries out a comprehensive analysis of historical trends and future predictions,to provide valuable insights into the complex interactions between urban expansion and landscape stability.The results indicate that:1)between 1980 and2020,Hangzhou experienced a significant increase in construction land at the expense of arable land,leading to a gradual decline in landscape stability,though the downward trend has slowed in recent years.2)The spatial distribution of landscape stability shows clear aggregation patterns,with lower stability concentrated in economically active flatlands and higher stability in the mountainous western regions.3)By 2040,further urban expansion is predicted to occur alongside increased landscape integration,reflecting the positive effects of ecological protection strategies.This study highlights the universal challenges of balancing economic growth with ecological stability in rapidly urbanizing regions.The combination of advanced simulation models and spatiotemporal analysis demonstrates a replicable framework for assessing urban expansion's ecological impacts.These findings underscore the importance of tailoring urban planning and ecological policies to address regional disparities,providing valuable insights for sustainable urban development and landscape management globally.展开更多
近15年来,语言景观已成为国际社会语言学研究的重要领域,学科体系日趋成熟。相比之下,中国语言景观研究虽发展迅速,但现有研究的学科意识和问题意识明显不足。本研究从国际语言景观学科的问题导向、研究方法及社会应用价值三个维度对Lin...近15年来,语言景观已成为国际社会语言学研究的重要领域,学科体系日趋成熟。相比之下,中国语言景观研究虽发展迅速,但现有研究的学科意识和问题意识明显不足。本研究从国际语言景观学科的问题导向、研究方法及社会应用价值三个维度对Linguistic Landscape:An International Journal这一国际学术期刊自创刊10年来的143篇文献进行计量分析,探究国际语言景观学科发展的新动态及创新路径。本研究对中国语言景观研究聚焦社会现实,开展学科建设,构建具有中国本土特色的语言景观研究的理论体系与方法体系具有启示作用。展开更多
Ecological security patterns are paramount to the advancement of an ecological civilization in China,aiming to enhance the stability and service functions of ecosystems to achieve sustainable regional development.Howe...Ecological security patterns are paramount to the advancement of an ecological civilization in China,aiming to enhance the stability and service functions of ecosystems to achieve sustainable regional development.However,current regional ecological protection efforts have not been effectively integrated into the regional development planning of ecological security pattern.This study systematically assessed the effectiveness of ecological protection projects in Yanchi County,Ningxia Hui Autonomous Region,China,through the evaluation of landscape ecological quality.Based on the evaluation results of landscape ecological quality,this study used morphological pattern analysis(MSPA),minimum cumulative resistance(MCR)model,and gravity model together to construct the ecological security pattern of Yanchi County.The findings revealed that from 1990 to 2020,with the implementation of ecological protection projects started from 2000,the landscape stability of Yanchi County first decreased and then increased,and the intensity of landscape disturbance first intensified but then decreased,indicating an improvement in the landscape ecological quality and a significant enhancement of the ecological environment in Yanchi County.The ecological security pattern of Yanchi County consisted of 10 ecological sources,10 ecological source points,23 ecological corridors,and 27 ecological nodes.The ecological security pattern of Yanchi County exhibited distinct spatial variations,with stronger ecological security observed in the southern part than in northern part of the county.The ecological sources were denser in the southern part than in the northern part of the county,and accordingly,the length of ecological corridors was shorter and denser in the southern than that in the northern part of the county.Based on the spatial distribution of landscape ecological quality and the characteristics of ecological security pattern of Yanchi County in 2020,we suggested Yanchi County to build four zones to optimize the ecological security pattern construction:the Haba Lake ecological conservation zone,the urban ecological planning zone,the ecological environment restoration zone,and the ecological security improvement zone.This study can provide essential guidance for the construction of ecological security pattern in farming-pastoral areas both in China and worldwide.展开更多
The internal road landscapes of Xizang Cultural Tourism and Creative Park at an altitude of 3,650 m were taken as the research object,and focusing on the restrictive effect of the high-altitude extreme environment on ...The internal road landscapes of Xizang Cultural Tourism and Creative Park at an altitude of 3,650 m were taken as the research object,and focusing on the restrictive effect of the high-altitude extreme environment on the road landscapes,data were collected through data crawling and survey questionnaires.Post occupancy evaluation(POE)was used to establish an evaluation system containing five dimensions and 24 indicators(including five high-altitude specific indicators),and statistical analysis was conducted by using multiple methods such as the analytic hierarchy process(AHP),SD semantic difference method,and IPA image analysis method.The results show that the respondents are generally satisfied with the overall evaluation of road landscapes in Xizang Cultural Tourism and Creative Park.However,the performance of high-altitude associated indicators is worrying.That is,anti-glare safety requirements are not met,and the survival rate of plateau plants is lower than the requirements of landscape effect;the integration of cultural landscapes fails to reflect regional culture.Based on this,high-altitude adaptive design strategies of three-dimensional synergy of“culture,ecology and security”were proposed to provide a certain paradigm reference for the evaluation and design of road landscapes in high-altitude areas.展开更多
To investigate the application of virtual digital technology in landscape engineering design,the study adopted the enu-meration survey method and observation method.It conducted a comprehensive analysis of the current...To investigate the application of virtual digital technology in landscape engineering design,the study adopted the enu-meration survey method and observation method.It conducted a comprehensive analysis of the current status and existing chal-lenges of virtual digital technology in landscape engineering design.Additionally,the study provided a detailed description and explanation of the integration between virtual digital technology and landscape engineering design,while exploring its charac-teristics and application prospects.The findings revealed:(1)In the early design stage,technological integration enhanced design efficiency.The collaborative use of BIM,GIS,and parametric tools enabled a fully digital workflow from conceptual design to construction drawings,reducing design errors and shortening project timelines.(2)After implementation,interactive experiences revolutionized public engagement.AR/VR technologies introduced dynamic interactivity to landscapes,while metaverse plat-forms expanded the presentation dimensions of virtual landscapes.(3)Smart maintenance promoted sustainability.IoT sensors and AI analytics facilitated real-time plant health monitoring and precise resource management,demonstrating significant advan-tages.The study identified existing limitations and proposed future directions,aiming to provide new theoretical and practical insights for the research and application of digital technology in landscape engineering design.展开更多
In the wave of urbanization,waterfront landscape optimization is very important,but it is faced with ecological deterioration and other problems.By combing the relevant theories and practices at home and abroad and ma...In the wave of urbanization,waterfront landscape optimization is very important,but it is faced with ecological deterioration and other problems.By combing the relevant theories and practices at home and abroad and making a comparison and summary,the future direction of waterfront research was analyzed.In theory,foreign research has experienced multi-stage development,covering definition classification,design methods,etc.China started late,and is mainly in the exploration stage of learning from foreign experience and combining with local characteristics.The current research and practice have shortcomings such as ignoring users’needs and lacking quantitative evaluation.In the future,the construction of waterfront should focus on the needs of users,use scientific methods to build an evaluation system,integrate multi-disciplines,excavate regional culture,and establish a monitoring mechanism to achieve sustainable and coordinated development of the ecology,society and economy of waterfront.展开更多
Alzheimer's disease (AD) is an age-related neurodegenerative disease that involves a progressive decline in memory,thinking,a nd learning.AD has been studied rigorously for more than 50 years yet there is a marked...Alzheimer's disease (AD) is an age-related neurodegenerative disease that involves a progressive decline in memory,thinking,a nd learning.AD has been studied rigorously for more than 50 years yet there is a marked lack of progress in pharmacological treatment.The challenges to developing AD therapeutics are rooted in the disease being ill-defined in terms of diagnosis,progression,and etiology.The neuropathological hallmarks of AD are extracellular amyloid-β (Aβ)plaques and intracellular neurofibrillary tangles of hyperphosphorylated tau.Generally,Aβ plaques disrupt neuronal connectivity,while neurofibrillary tangles interfere with intracellular function (Zhang et al.,2023).展开更多
In recent years,the scale of sports consumption in China has continued to expand,demonstrating a vigorous development momentum.According to the "2025-2031 In-depth Research on China's Sports Industry and Futu...In recent years,the scale of sports consumption in China has continued to expand,demonstrating a vigorous development momentum.According to the "2025-2031 In-depth Research on China's Sports Industry and Future Development Trends Report." the total scale of the national sports industry reached RMB 3,117.5 billion in2024.with an added value of RMB 1,224.5 billion.Compared with 2023,the total output increased by 13.9%,and the added value grew by 14.1%.Behind these series of numbers lies the rapid development of China's sports industry and the continuous growth of market demand.展开更多
Oral squamous cell carcinoma(OSCC)is the most common manifestation of oral cancer.It has been proposed that periodontal pathogens contribute to OSCC progression,mainly by their virulence factors.However,the main perio...Oral squamous cell carcinoma(OSCC)is the most common manifestation of oral cancer.It has been proposed that periodontal pathogens contribute to OSCC progression,mainly by their virulence factors.However,the main periodontal pathogen and its mechanism to modulate OSCC cells remains not fully understood.In this study we investigate the main host-pathogen pathways in OSCC by computational proteomics and the mechanism behind cancer progression by the oral microbiome.The main hostpathogen pathways were analyzed in the secretome of biopsies from patients with OSCC and healthy controls by mass spectrometry.Then,functional assays were performed to evaluate the host-pathogen pathways highlighted in oral cancer.Host proteins associated with LPS response,cell migration/adhesion,and metabolism of amino acids were significantly upregulated in the human cancer proteome,whereas the complement cascade was downregulated in malignant samples.Then,the microbiome analysis revealed large number and variety of peptides from Fusobacterium nucleatum(F.nucleatum)in OSCC samples,from which several enzymes from the L-glutamate degradation pathway were found,indicating that L-glutamate from cancer cells is used as an energy source,and catabolized into butyrate by the bacteria.In fact,we observed that F.nucleatum modulates the cystine/glutamate antiporter in an OSCC cell line by increasing SLC7A11 expression,promoting L-glutamate efflux and favoring bacterial infection.Finally,our results showed that F.nucleatum and its metabolic derivates promote tumor spheroids growth,spheroidsderived cell detachment,epithelial-mesenchymal transition and Galectin-9 upregulation.Altogether,F.nucleatum promotes protumoral mechanism in oral cancer.展开更多
The comprehensive treatment of river courses and their landscape environments have attracted more and more attention of the society.However,due to its wide coverage,technical difficulties and long restoration period,d...The comprehensive treatment of river courses and their landscape environments have attracted more and more attention of the society.However,due to its wide coverage,technical difficulties and long restoration period,designers need to explore,research and design with a more comprehensive and longer-term planning perspective,and a more comprehensive professional strength.Taking the comprehensive regulation and landscape design of Mayuanxi River in Chongqing as an example,this paper integrated the regulation,ecological restoration,landscape construction,project planning and cultural display of the river,and systematically put forward ideas and strategies for the comprehensive regulation and landscape design of the river,with a view to making a beneficial exploration for the research in this field.Notably,the paper highlighted innovative techniques such as vegetation concrete for revetment and rainwater gardens for ecological rainwater management.展开更多
Editor’s Note:On the northeastern edge of the Qinghai-Xizang Plateau,Qinghai weaves a dynamic ecological symphony composed of four distinct natural languages.Here,one can find not only solidified waves-represented by...Editor’s Note:On the northeastern edge of the Qinghai-Xizang Plateau,Qinghai weaves a dynamic ecological symphony composed of four distinct natural languages.Here,one can find not only solidified waves-represented by the crystal-clear Qarhan Salt Lake-but also flowing flames-the passionate hues of the Guide Danxia landscape.展开更多
This study offers valuable insights into the relationship between metro ridership patterns and the spatial transformations around Delhi Metro stations,underscoring the role of mass transit infrastructure in shaping ur...This study offers valuable insights into the relationship between metro ridership patterns and the spatial transformations around Delhi Metro stations,underscoring the role of mass transit infrastructure in shaping urban land use and ecosystem landscapes.The primary objective is to assess how high-ridership metro stations can positively influence urban development,particularly regarding socio-economic and ecological dimensions.Integrating primary survey data with ridership statistics from the Delhi Metro Rail Corporation(DMRC),the research identifies key interchange stations,such as Kashmere Gate and Rajiv Chowk,which exhibit substantial passenger volumes.Utilising GIS-based spatial analysis and remote sensing techniques,land use changes within a 500-meter buffer zone around these stations are considered,focusing on built-up areas,green cover,and open space availability.Time-series satellite imagery generates comparative maps illustrating land use changes pre-and post-introduction of metro services.The analysis reveals that high-ridership stations are linked to significant commercial densification,particularly near Rajiv Chowk,with a p-value of 0.172.Conversely,peripheral stations like Dwarka Sector 21 indicate residential growth trends,with a p-value of 0.087 for residential areas.Importantly,two land use categories—Green Space(t=-2.33,p=0.045)and Open Space(t=3.57,p=0.006)—show statistically significant reductions,highlighting the ecological impacts of metro infrastructure.The findings suggest that metro systems can promote commercial clustering in urban centres while fostering residential growth in surrounding areas.Overall,the study highlights the potential of metro systems to enhance accessibility,reshape urban ecosystems,and encourage the development of compact urban forms.The implications for urban planning advocate for transit-oriented development(TOD)as a strategic approach to manage growth,minimise sprawl,and ensure sustainable and inclusive development.展开更多
The outdoor landscape design of medical buildings affects the healthcare experience of patients and the work environment of medical staff.Therapeutic landscapes contribute to the recovery of patients and provide a com...The outdoor landscape design of medical buildings affects the healthcare experience of patients and the work environment of medical staff.Therapeutic landscapes contribute to the recovery of patients and provide a comfortable,convenient,and safe outdoor space for both patients and healthcare professionals.This article analyzes the concept,classification,design necessity,and smart enhancement methods of therapeutic landscapes.By combining the case study of the wellness landscape design of the Fifth People’s Hospital of Chongqing,it derives insights into therapeutic landscape design,such as the rational use of natural elements,the construction of pedestrian space systems,the arrangement of specialized botanical gardens,the integration of multiple therapies,and the application of smart technologies.The aim is to promote the development of therapeutic outdoor landscape design for medical buildings.展开更多
Tree canopy landscapes are an important component of urban forests and have the potential to influence human emotions.However,their influence on emotional responses remains unclear.The aims of this study were:(1)to de...Tree canopy landscapes are an important component of urban forests and have the potential to influence human emotions.However,their influence on emotional responses remains unclear.The aims of this study were:(1)to determine whether the canopy landscape affects human emotions;(2)to clarify the influence of canopy landscape on individual emotional indicators;and(3)to identify the ratio of canopy landscape elements with the most beneficial effects on human emotions.Different canopy landscape images were generated,and the self-reported emotions and neural activity of the subjects assessed before and after they viewed the images.The results of the statistical analysis were intuitively displayed by a ternary phase diagram.We found that the canopy landscape affected human emotions and different proportions of canopy landscape elements led to significant differences in excitement,depression and confusion.Higher proportions of blue elements and lower proportions of green and other elements characterized the canopy landscape with the most beneficial effect on human emotions.These findings will promote further research on canopy landscapes,inform the planning and design of urban forests,and contribute to the field of landscape architecture.展开更多
文摘Through analyzing problems in the planning of green space system in cities of China,strategies for constructing urban green space system are put forward based on the requirements of conservation-oriented landscape.
文摘The rapidly aging population directly contributes to the increasing cases of neurological disorders.Due to the chronic progressive nature of neurodegeneration,numerous neurological conditions are considered“multifactorial”with systemic metabolic alterations.Even so,treatments for neurological disorders have remained unchanged for the past decades.Recently,metabolic drugs such as metformin and glucagon-like peptide 1 agonists have demonstrated promising health outcomes for neurodegeneration.
文摘With the progress of urbanization,urban landscape design has garnered increasing attention.Urban landscape design can not only reflect the construction level of a city but also has the functions of beautifying the urban environment and enhancing the city image.Modern art enriches the expression forms of urban landscape design,and its integration with urban landscape design can greatly improve the urban landscape.This article elaborated on the connotations of modern art and urban landscape design and analyzed the application of modern art in urban landscape design.The application of modern art can help to achieve the goal of urban landscape design to the maximum extent.
文摘In the context of rural revitalization,the landscape design of public spaces in Enshi Xiaomaopoying Village presents both new opportunities and challenges.This study explores the significance of integrating regional culture into rural public spaces.Field research has been conducted to assess the current utilization of regional culture in the public spaces of Xiaomaopoying Village.Subsequently,design optimization strategies are analyzed and proposed.Additionally,the practical application of regional cultural elements is examined,in order to offer guidance for the application of cultural creation of traditional characteristic villages in rural public spaces.
基金Under the auspices of Zhejiang Provincial Natural Science Foundation of China(No.LY19C160007)。
文摘In recent years,rapid urbanization has had a profound impact on landscape stability.As a typical example of China's rapid urbanization,Hangzhou has also experienced significant landscape changes,which have profoundly affected its ecological stability.Taking Hangzhou as an example,this study integrates land use change data from 1980 to 2020,combines dynamic simulation and ecological modeling techniques,and carries out a comprehensive analysis of historical trends and future predictions,to provide valuable insights into the complex interactions between urban expansion and landscape stability.The results indicate that:1)between 1980 and2020,Hangzhou experienced a significant increase in construction land at the expense of arable land,leading to a gradual decline in landscape stability,though the downward trend has slowed in recent years.2)The spatial distribution of landscape stability shows clear aggregation patterns,with lower stability concentrated in economically active flatlands and higher stability in the mountainous western regions.3)By 2040,further urban expansion is predicted to occur alongside increased landscape integration,reflecting the positive effects of ecological protection strategies.This study highlights the universal challenges of balancing economic growth with ecological stability in rapidly urbanizing regions.The combination of advanced simulation models and spatiotemporal analysis demonstrates a replicable framework for assessing urban expansion's ecological impacts.These findings underscore the importance of tailoring urban planning and ecological policies to address regional disparities,providing valuable insights for sustainable urban development and landscape management globally.
文摘近15年来,语言景观已成为国际社会语言学研究的重要领域,学科体系日趋成熟。相比之下,中国语言景观研究虽发展迅速,但现有研究的学科意识和问题意识明显不足。本研究从国际语言景观学科的问题导向、研究方法及社会应用价值三个维度对Linguistic Landscape:An International Journal这一国际学术期刊自创刊10年来的143篇文献进行计量分析,探究国际语言景观学科发展的新动态及创新路径。本研究对中国语言景观研究聚焦社会现实,开展学科建设,构建具有中国本土特色的语言景观研究的理论体系与方法体系具有启示作用。
基金funded by the National Natural Science Foundation of China(41807519)the Open Fund Project of Key Laboratory of Deserts and Desertification,Chinese Academy of Sciences(KLDD-2018-002).
文摘Ecological security patterns are paramount to the advancement of an ecological civilization in China,aiming to enhance the stability and service functions of ecosystems to achieve sustainable regional development.However,current regional ecological protection efforts have not been effectively integrated into the regional development planning of ecological security pattern.This study systematically assessed the effectiveness of ecological protection projects in Yanchi County,Ningxia Hui Autonomous Region,China,through the evaluation of landscape ecological quality.Based on the evaluation results of landscape ecological quality,this study used morphological pattern analysis(MSPA),minimum cumulative resistance(MCR)model,and gravity model together to construct the ecological security pattern of Yanchi County.The findings revealed that from 1990 to 2020,with the implementation of ecological protection projects started from 2000,the landscape stability of Yanchi County first decreased and then increased,and the intensity of landscape disturbance first intensified but then decreased,indicating an improvement in the landscape ecological quality and a significant enhancement of the ecological environment in Yanchi County.The ecological security pattern of Yanchi County consisted of 10 ecological sources,10 ecological source points,23 ecological corridors,and 27 ecological nodes.The ecological security pattern of Yanchi County exhibited distinct spatial variations,with stronger ecological security observed in the southern part than in northern part of the county.The ecological sources were denser in the southern part than in the northern part of the county,and accordingly,the length of ecological corridors was shorter and denser in the southern than that in the northern part of the county.Based on the spatial distribution of landscape ecological quality and the characteristics of ecological security pattern of Yanchi County in 2020,we suggested Yanchi County to build four zones to optimize the ecological security pattern construction:the Haba Lake ecological conservation zone,the urban ecological planning zone,the ecological environment restoration zone,and the ecological security improvement zone.This study can provide essential guidance for the construction of ecological security pattern in farming-pastoral areas both in China and worldwide.
基金Sponsored by the Joint Training Base Project for Master’s Degree Students in Landscape Architecture of Chongqing Jiaotong University and China Merchants Ecological and Environmental Protection Technology Co.,Ltd.(JDLHPY.JD2019003)General Project of Chongqing Natural Science Foundation of China in 2024(CSTB2024NSCQ-MSX1067)Key Project of Humanities and Social Sciences of Chongqing City in 2024(24SKGH346).
文摘The internal road landscapes of Xizang Cultural Tourism and Creative Park at an altitude of 3,650 m were taken as the research object,and focusing on the restrictive effect of the high-altitude extreme environment on the road landscapes,data were collected through data crawling and survey questionnaires.Post occupancy evaluation(POE)was used to establish an evaluation system containing five dimensions and 24 indicators(including five high-altitude specific indicators),and statistical analysis was conducted by using multiple methods such as the analytic hierarchy process(AHP),SD semantic difference method,and IPA image analysis method.The results show that the respondents are generally satisfied with the overall evaluation of road landscapes in Xizang Cultural Tourism and Creative Park.However,the performance of high-altitude associated indicators is worrying.That is,anti-glare safety requirements are not met,and the survival rate of plateau plants is lower than the requirements of landscape effect;the integration of cultural landscapes fails to reflect regional culture.Based on this,high-altitude adaptive design strategies of three-dimensional synergy of“culture,ecology and security”were proposed to provide a certain paradigm reference for the evaluation and design of road landscapes in high-altitude areas.
基金Basic scientific research business expenses of universities directly under Inner Mongolia Autonomous Region,Key project of Philosophy and Social Science Foundation of Inner Mongolia Agricultural University(BR220603)Special project for improving scientific research ability of young teachers of Inner Mongolia Agricultural University(BR230218).
文摘To investigate the application of virtual digital technology in landscape engineering design,the study adopted the enu-meration survey method and observation method.It conducted a comprehensive analysis of the current status and existing chal-lenges of virtual digital technology in landscape engineering design.Additionally,the study provided a detailed description and explanation of the integration between virtual digital technology and landscape engineering design,while exploring its charac-teristics and application prospects.The findings revealed:(1)In the early design stage,technological integration enhanced design efficiency.The collaborative use of BIM,GIS,and parametric tools enabled a fully digital workflow from conceptual design to construction drawings,reducing design errors and shortening project timelines.(2)After implementation,interactive experiences revolutionized public engagement.AR/VR technologies introduced dynamic interactivity to landscapes,while metaverse plat-forms expanded the presentation dimensions of virtual landscapes.(3)Smart maintenance promoted sustainability.IoT sensors and AI analytics facilitated real-time plant health monitoring and precise resource management,demonstrating significant advan-tages.The study identified existing limitations and proposed future directions,aiming to provide new theoretical and practical insights for the research and application of digital technology in landscape engineering design.
文摘In the wave of urbanization,waterfront landscape optimization is very important,but it is faced with ecological deterioration and other problems.By combing the relevant theories and practices at home and abroad and making a comparison and summary,the future direction of waterfront research was analyzed.In theory,foreign research has experienced multi-stage development,covering definition classification,design methods,etc.China started late,and is mainly in the exploration stage of learning from foreign experience and combining with local characteristics.The current research and practice have shortcomings such as ignoring users’needs and lacking quantitative evaluation.In the future,the construction of waterfront should focus on the needs of users,use scientific methods to build an evaluation system,integrate multi-disciplines,excavate regional culture,and establish a monitoring mechanism to achieve sustainable and coordinated development of the ecology,society and economy of waterfront.
基金supported by a New Investigator grant from the Alzheimer’s Society of Canadaresearch grant from Djavad Mowafaghian Centre for Brain Health to KSAE。
文摘Alzheimer's disease (AD) is an age-related neurodegenerative disease that involves a progressive decline in memory,thinking,a nd learning.AD has been studied rigorously for more than 50 years yet there is a marked lack of progress in pharmacological treatment.The challenges to developing AD therapeutics are rooted in the disease being ill-defined in terms of diagnosis,progression,and etiology.The neuropathological hallmarks of AD are extracellular amyloid-β (Aβ)plaques and intracellular neurofibrillary tangles of hyperphosphorylated tau.Generally,Aβ plaques disrupt neuronal connectivity,while neurofibrillary tangles interfere with intracellular function (Zhang et al.,2023).
文摘In recent years,the scale of sports consumption in China has continued to expand,demonstrating a vigorous development momentum.According to the "2025-2031 In-depth Research on China's Sports Industry and Future Development Trends Report." the total scale of the national sports industry reached RMB 3,117.5 billion in2024.with an added value of RMB 1,224.5 billion.Compared with 2023,the total output increased by 13.9%,and the added value grew by 14.1%.Behind these series of numbers lies the rapid development of China's sports industry and the continuous growth of market demand.
基金supported by Agencia Nacional de Investigación y Desarrollo(ANID),Chilean Government Fondecyt Regular 1211480supported by a Master ANID Scholarship+1 种基金funded by ANID/Fondecyt Regular 1211480funded by EQM150061(FONDEQUIP-ANID)。
文摘Oral squamous cell carcinoma(OSCC)is the most common manifestation of oral cancer.It has been proposed that periodontal pathogens contribute to OSCC progression,mainly by their virulence factors.However,the main periodontal pathogen and its mechanism to modulate OSCC cells remains not fully understood.In this study we investigate the main host-pathogen pathways in OSCC by computational proteomics and the mechanism behind cancer progression by the oral microbiome.The main hostpathogen pathways were analyzed in the secretome of biopsies from patients with OSCC and healthy controls by mass spectrometry.Then,functional assays were performed to evaluate the host-pathogen pathways highlighted in oral cancer.Host proteins associated with LPS response,cell migration/adhesion,and metabolism of amino acids were significantly upregulated in the human cancer proteome,whereas the complement cascade was downregulated in malignant samples.Then,the microbiome analysis revealed large number and variety of peptides from Fusobacterium nucleatum(F.nucleatum)in OSCC samples,from which several enzymes from the L-glutamate degradation pathway were found,indicating that L-glutamate from cancer cells is used as an energy source,and catabolized into butyrate by the bacteria.In fact,we observed that F.nucleatum modulates the cystine/glutamate antiporter in an OSCC cell line by increasing SLC7A11 expression,promoting L-glutamate efflux and favoring bacterial infection.Finally,our results showed that F.nucleatum and its metabolic derivates promote tumor spheroids growth,spheroidsderived cell detachment,epithelial-mesenchymal transition and Galectin-9 upregulation.Altogether,F.nucleatum promotes protumoral mechanism in oral cancer.
基金Supported by General Project of Chongqing Natural Science Foundation(CSTB2024NSCQ-MSX1067)Key Project of Humanities and Social Sciences of Chongqing Municipal Education Commission(24SKGH346)Natural Science Project of Chongqing College of Humanities,Science and Technology(CRKZK2023010).
文摘The comprehensive treatment of river courses and their landscape environments have attracted more and more attention of the society.However,due to its wide coverage,technical difficulties and long restoration period,designers need to explore,research and design with a more comprehensive and longer-term planning perspective,and a more comprehensive professional strength.Taking the comprehensive regulation and landscape design of Mayuanxi River in Chongqing as an example,this paper integrated the regulation,ecological restoration,landscape construction,project planning and cultural display of the river,and systematically put forward ideas and strategies for the comprehensive regulation and landscape design of the river,with a view to making a beneficial exploration for the research in this field.Notably,the paper highlighted innovative techniques such as vegetation concrete for revetment and rainwater gardens for ecological rainwater management.
文摘Editor’s Note:On the northeastern edge of the Qinghai-Xizang Plateau,Qinghai weaves a dynamic ecological symphony composed of four distinct natural languages.Here,one can find not only solidified waves-represented by the crystal-clear Qarhan Salt Lake-but also flowing flames-the passionate hues of the Guide Danxia landscape.
基金funded by the Institution of Eminence,with the University of Delhi cited as IoE/2024-25/12/FRP.
文摘This study offers valuable insights into the relationship between metro ridership patterns and the spatial transformations around Delhi Metro stations,underscoring the role of mass transit infrastructure in shaping urban land use and ecosystem landscapes.The primary objective is to assess how high-ridership metro stations can positively influence urban development,particularly regarding socio-economic and ecological dimensions.Integrating primary survey data with ridership statistics from the Delhi Metro Rail Corporation(DMRC),the research identifies key interchange stations,such as Kashmere Gate and Rajiv Chowk,which exhibit substantial passenger volumes.Utilising GIS-based spatial analysis and remote sensing techniques,land use changes within a 500-meter buffer zone around these stations are considered,focusing on built-up areas,green cover,and open space availability.Time-series satellite imagery generates comparative maps illustrating land use changes pre-and post-introduction of metro services.The analysis reveals that high-ridership stations are linked to significant commercial densification,particularly near Rajiv Chowk,with a p-value of 0.172.Conversely,peripheral stations like Dwarka Sector 21 indicate residential growth trends,with a p-value of 0.087 for residential areas.Importantly,two land use categories—Green Space(t=-2.33,p=0.045)and Open Space(t=3.57,p=0.006)—show statistically significant reductions,highlighting the ecological impacts of metro infrastructure.The findings suggest that metro systems can promote commercial clustering in urban centres while fostering residential growth in surrounding areas.Overall,the study highlights the potential of metro systems to enhance accessibility,reshape urban ecosystems,and encourage the development of compact urban forms.The implications for urban planning advocate for transit-oriented development(TOD)as a strategic approach to manage growth,minimise sprawl,and ensure sustainable and inclusive development.
基金Research Fund Projects of Chongqing Institute of Engineering:Research on the Intelligent Design of Indoor and Outdoor Spaces for Chongqing’s“Integrated Medical and Elderly Care”Health and Wellness Buildings in the Context of Digitization(Project No.:2023xsky01)Research on Spatial Syntax Parameters and Combination Patterns of Urban and Rural Community Elderly Care Centers from a Multi-Dimensional Perspective(Project No.:2024XZKY003)2024 Curriculum Ideological and Political Demonstration Course Construction Project of Chongqing Institute of Engineering,“Residential Landscape Design”(Project No.:KC20240006)。
文摘The outdoor landscape design of medical buildings affects the healthcare experience of patients and the work environment of medical staff.Therapeutic landscapes contribute to the recovery of patients and provide a comfortable,convenient,and safe outdoor space for both patients and healthcare professionals.This article analyzes the concept,classification,design necessity,and smart enhancement methods of therapeutic landscapes.By combining the case study of the wellness landscape design of the Fifth People’s Hospital of Chongqing,it derives insights into therapeutic landscape design,such as the rational use of natural elements,the construction of pedestrian space systems,the arrangement of specialized botanical gardens,the integration of multiple therapies,and the application of smart technologies.The aim is to promote the development of therapeutic outdoor landscape design for medical buildings.
基金co-funded by the Talent Initiation Program of the Scientific Research Development Fund of Zhejiang A&F University(2021LFR041and 2022LFR040)the National Natural Science Foundation of China(52278084).
文摘Tree canopy landscapes are an important component of urban forests and have the potential to influence human emotions.However,their influence on emotional responses remains unclear.The aims of this study were:(1)to determine whether the canopy landscape affects human emotions;(2)to clarify the influence of canopy landscape on individual emotional indicators;and(3)to identify the ratio of canopy landscape elements with the most beneficial effects on human emotions.Different canopy landscape images were generated,and the self-reported emotions and neural activity of the subjects assessed before and after they viewed the images.The results of the statistical analysis were intuitively displayed by a ternary phase diagram.We found that the canopy landscape affected human emotions and different proportions of canopy landscape elements led to significant differences in excitement,depression and confusion.Higher proportions of blue elements and lower proportions of green and other elements characterized the canopy landscape with the most beneficial effect on human emotions.These findings will promote further research on canopy landscapes,inform the planning and design of urban forests,and contribute to the field of landscape architecture.
