Background Conditional relative survival(CRS),the probability of survival given that an individual has already survived a certain period post-diagnosis,is a more clinically relevant measure for long-term survival than...Background Conditional relative survival(CRS),the probability of survival given that an individual has already survived a certain period post-diagnosis,is a more clinically relevant measure for long-term survival than standard relative survival(RS).This study aims to evaluate the 5-year CRS among adolescent and young adult(AYA)breast cancer patients by age,tumor stage,and receptor subtype to guide disclosure periods for insurance.Methods Data of all females aged 18–39 years and diagnosed with invasive breast cancer between 2003 and 2021(n=13,075)were obtained from The Netherlands Cancer Registry(NCR).The five-year CRS was calculated annually up to 10 years post-diagnosis using a hybrid analysis approach.Results For the total AYA breast cancer study population the 5-year CRS exceeded 90%from diagnosis and increased beyond 95%7 years post-diagnosis.Patients aged 18–24 reached 95%9 years post-diagnosis,those aged 25–29 after 5 years,and those aged 30–34 and 35–39 after 8 years.For stage I,the 5-year CRS reached 95%from diagnosis,for stage II after 6 years,while the 5-year CRS for stages III and IV did not reach the 95%threshold during the 10-year follow-up.Triple-negative tumors exceeded 95%after 4 years,human epidermal growth factor receptor 2(HER2)positive tumors after 6 years,while hormone receptor(HR)positive tumors did not reach 95%.Conclusion Excess mortality among AYA breast cancer patients tends to be little(CRS 90%–95%)from diagnosis and becomes minimal(CRS>95%)over time compared to the general population.These results can enhance expectation management and inform policymakers,suggesting a shorter disclosure period.展开更多
Neurodegeneration is one of the biggest public health problems in modern society. Age-associated neurodegeneration, which is accelerated several-fold in Alzheimer＇s disease （AD） alone, is not only an enormous socia...Neurodegeneration is one of the biggest public health problems in modern society. Age-associated neurodegeneration, which is accelerated several-fold in Alzheimer＇s disease （AD） alone, is not only an enormous social and economic burden to the affected in- dividuals and their families, but is also a great scientific challenge. Currently 25-35 million people worldwide suffer from AD, the single largest cause of dementia in middle- to old-aged individuals. These numbers are projected to triple by 2050 if no treatment to prevent or reverse AD is developed.展开更多
Parameter uncertainty is a primary source of uncertainty in ocean ecosystem simulations.The deep chlorophyll maximum(DCM)is a ubiquitous ecological phenomenon in the ocean.Using a theoretical nutrients-phytoplankton m...Parameter uncertainty is a primary source of uncertainty in ocean ecosystem simulations.The deep chlorophyll maximum(DCM)is a ubiquitous ecological phenomenon in the ocean.Using a theoretical nutrients-phytoplankton model and the conditional nonlinear optimal perturbation approach related to parameters,we investigated the eff ects of parameter uncertainties on DCM simulations.First,the sensitivity of single parameter was analyzed.The sensitivity ranking of 10 parameters was obtained by analyzing the top four specifi cally.The most sensitive parameter(background turbidity)aff ects the light supply for DCM formation,whereas the other three parameters(nutrient content of phytoplankton,nutrient recycling coeffi cient,and vertical turbulent diff usivity)control nutrient supply.To explore the interactions among diff erent parameters,the sensitivity of multiple parameters was further studied by examining combinations of four parameters.The results show that background turbidity is replaced by the phytoplankton loss rate in the optimal parameter combination.In addition,we found that interactions among these parameters are responsible for such diff erences.Finally,we found that reducing the uncertainties of sensitive parameters could improve DCM simulations remarkably.Compared with the sensitive parameters identifi ed in the single parameter analysis,reducing parameter uncertainties in the optimal combination produced better model performance.This study shows the importance of nonlinear interactions among various parameters in identifying sensitive parameters.In the future,the conditional nonlinear optimal perturbation approach related to parameters,especially optimal parameter combinations,is expected to greatly improve DCM simulations in complex ecosystem models.展开更多
In this paper,we set out to study the ensemble forecast for tropical cyclones.The case study is based on the Conditional Nonlinear Optimal Perturbation related to Parameter(CNOP-P)method and the WRF model to improve t...In this paper,we set out to study the ensemble forecast for tropical cyclones.The case study is based on the Conditional Nonlinear Optimal Perturbation related to Parameter(CNOP-P)method and the WRF model to improve the prediction accuracy for track and intensity,and two different typhoons are selected as cases for analysis.We first select perturbed parameters in the YSU and WSM6 schemes,and then solve CNOP-Ps with simulated annealing algorithm for single parameters as well as the combination of multiple parameters.Finally,perturbations are imposed on default parameter values to generate the ensemble members.The whole proposed procedures are referred to as the PerturbedParameter Ensemble(PPE).We also conduct two experiments,which are control forecast and ensemble forecast,termed Ctrl and perturbed-physics ensemble(PPhyE)respectively,to demonstrate the performance for contrast.In the article,we compare the effects of three experiments on tropical cyclones in aspects of track and intensity,respectively.For track,the prediction errors of PPE are smaller.The ensemble mean of PPE filters the unpredictable situation and retains the reasonably predictable components of the ensemble members.As for intensity,ensemble mean values of the central minimum sea-level pressure and the central maximum wind speed are closer to CMA data during most of the simulation time.The predicted values of the PPE ensemble members included the intensity of CMA data when the typhoon made landfall.The PPE also shows uncertainty in the forecast.Moreover,we also analyze the track and intensity from physical variable fields of PPE.Experiment results show PPE outperforms the other two benchmarks in track and intensity prediction.展开更多
基金supported by The Netherlands Organization for Scientific Research VIDI(grant number:198.007).
文摘Background Conditional relative survival(CRS),the probability of survival given that an individual has already survived a certain period post-diagnosis,is a more clinically relevant measure for long-term survival than standard relative survival(RS).This study aims to evaluate the 5-year CRS among adolescent and young adult(AYA)breast cancer patients by age,tumor stage,and receptor subtype to guide disclosure periods for insurance.Methods Data of all females aged 18–39 years and diagnosed with invasive breast cancer between 2003 and 2021(n=13,075)were obtained from The Netherlands Cancer Registry(NCR).The five-year CRS was calculated annually up to 10 years post-diagnosis using a hybrid analysis approach.Results For the total AYA breast cancer study population the 5-year CRS exceeded 90%from diagnosis and increased beyond 95%7 years post-diagnosis.Patients aged 18–24 reached 95%9 years post-diagnosis,those aged 25–29 after 5 years,and those aged 30–34 and 35–39 after 8 years.For stage I,the 5-year CRS reached 95%from diagnosis,for stage II after 6 years,while the 5-year CRS for stages III and IV did not reach the 95%threshold during the 10-year follow-up.Triple-negative tumors exceeded 95%after 4 years,human epidermal growth factor receptor 2(HER2)positive tumors after 6 years,while hormone receptor(HR)positive tumors did not reach 95%.Conclusion Excess mortality among AYA breast cancer patients tends to be little(CRS 90%–95%)from diagnosis and becomes minimal(CRS>95%)over time compared to the general population.These results can enhance expectation management and inform policymakers,suggesting a shorter disclosure period.
基金supported in part by the New York State Office of People with Developmental Disabilities(OPWDD)Zenith Award ZEN-12-241233 from Alzheimer’s Associationa research grant#20121203 from Alzheimer’s Drug Discovery Foundation,New York
文摘Neurodegeneration is one of the biggest public health problems in modern society. Age-associated neurodegeneration, which is accelerated several-fold in Alzheimer＇s disease （AD） alone, is not only an enormous social and economic burden to the affected in- dividuals and their families, but is also a great scientific challenge. Currently 25-35 million people worldwide suffer from AD, the single largest cause of dementia in middle- to old-aged individuals. These numbers are projected to triple by 2050 if no treatment to prevent or reverse AD is developed.
基金Supported by the Qingdao National Laboratory for Marine Science and Technology(No.2016OPR0107)the National Natural Science Foundation of China(No.41806013)。
文摘Parameter uncertainty is a primary source of uncertainty in ocean ecosystem simulations.The deep chlorophyll maximum(DCM)is a ubiquitous ecological phenomenon in the ocean.Using a theoretical nutrients-phytoplankton model and the conditional nonlinear optimal perturbation approach related to parameters,we investigated the eff ects of parameter uncertainties on DCM simulations.First,the sensitivity of single parameter was analyzed.The sensitivity ranking of 10 parameters was obtained by analyzing the top four specifi cally.The most sensitive parameter(background turbidity)aff ects the light supply for DCM formation,whereas the other three parameters(nutrient content of phytoplankton,nutrient recycling coeffi cient,and vertical turbulent diff usivity)control nutrient supply.To explore the interactions among diff erent parameters,the sensitivity of multiple parameters was further studied by examining combinations of four parameters.The results show that background turbidity is replaced by the phytoplankton loss rate in the optimal parameter combination.In addition,we found that interactions among these parameters are responsible for such diff erences.Finally,we found that reducing the uncertainties of sensitive parameters could improve DCM simulations remarkably.Compared with the sensitive parameters identifi ed in the single parameter analysis,reducing parameter uncertainties in the optimal combination produced better model performance.This study shows the importance of nonlinear interactions among various parameters in identifying sensitive parameters.In the future,the conditional nonlinear optimal perturbation approach related to parameters,especially optimal parameter combinations,is expected to greatly improve DCM simulations in complex ecosystem models.
基金National Key Research and Development Program of China(2020YFA0608002)Key Project Fund of Shanghai 2020“Science and Technology Innovation Action Plan”for Social Development(20dz1200702)+2 种基金National Natural Science Foundation of China(42075141)Meteorological Joint Funds of the National Natural Science Foundation of China(U2142211)Fundamental Research Funds for the Central Universities(13502150039/003)。
文摘In this paper,we set out to study the ensemble forecast for tropical cyclones.The case study is based on the Conditional Nonlinear Optimal Perturbation related to Parameter(CNOP-P)method and the WRF model to improve the prediction accuracy for track and intensity,and two different typhoons are selected as cases for analysis.We first select perturbed parameters in the YSU and WSM6 schemes,and then solve CNOP-Ps with simulated annealing algorithm for single parameters as well as the combination of multiple parameters.Finally,perturbations are imposed on default parameter values to generate the ensemble members.The whole proposed procedures are referred to as the PerturbedParameter Ensemble(PPE).We also conduct two experiments,which are control forecast and ensemble forecast,termed Ctrl and perturbed-physics ensemble(PPhyE)respectively,to demonstrate the performance for contrast.In the article,we compare the effects of three experiments on tropical cyclones in aspects of track and intensity,respectively.For track,the prediction errors of PPE are smaller.The ensemble mean of PPE filters the unpredictable situation and retains the reasonably predictable components of the ensemble members.As for intensity,ensemble mean values of the central minimum sea-level pressure and the central maximum wind speed are closer to CMA data during most of the simulation time.The predicted values of the PPE ensemble members included the intensity of CMA data when the typhoon made landfall.The PPE also shows uncertainty in the forecast.Moreover,we also analyze the track and intensity from physical variable fields of PPE.Experiment results show PPE outperforms the other two benchmarks in track and intensity prediction.
