This study evaluates the Fuzzy Analytical Hierarchy Process(FAHP)as a multi-criteria decision(MCD)support tool for selecting appropriate additive manufacturing(AM)techniques that align with cleaner production and envi...This study evaluates the Fuzzy Analytical Hierarchy Process(FAHP)as a multi-criteria decision(MCD)support tool for selecting appropriate additive manufacturing(AM)techniques that align with cleaner production and environmental sustainability.The FAHP model was validated using an example of the production of aircraft components(specifically fuselage)employing AM technologies such as Wire Arc Additive Manufacturing(WAAM),laser powder bed fusion(L-PBF),Binder Jetting(BJ),Selective Laser Sintering(SLS),and Laser Metal Deposition(LMD).The selection criteria prioritized eco-friendly manufacturing considerations,including the quality and properties of the final product(e.g.,surface finish,high strength,and corrosion resistance),service and functional requirements,weight reduction for improved energy efficiency(lightweight structures),and environmental responsibility.Sustainability metrics,such as cost-effectiveness,material efficiency,waste minimization,and environmental impact,are central to the evaluation process.A computer-aided modeling approach was also used to simulate the performance of aluminum(AA7075 T6),steel(304),and titanium alloy(Ti6Al4V)for fuselage development.The results demonstrate that MCD approaches such as FAHP can effectively guide the selection of AM technologies that meet functional and technical requirements while minimizing environmental degradation footprints.Furthermore,the aluminumalloy outperformed the other materials investigated in the simulation with the lowest stress concentration and least deformation.This study contributes to advancing cleaner production practices by providing a decision-making framework for sustainable and eco-friendly manufacturing,enabling manufacturers to adopt AM technologies that promote environmental responsibility and sustainable development,while maintaining product quality and performance.展开更多
Most existing treatments for origami-folding simulations have focused on regular-shaped configurations.This article aims to introduce a general strategy for simulating and analyzing the deformation process of irregula...Most existing treatments for origami-folding simulations have focused on regular-shaped configurations.This article aims to introduce a general strategy for simulating and analyzing the deformation process of irregular shapes by means of computational capabilities nowadays.To better simulate origami deformation with folding orders,the concept of plane follow-up is introduced to achieve automated computer simulation of complex folding patterns,thereby avoiding intersection and penetration between planes.Based on the evaluation criteria such as the lowest storage energy with tightening and the fastest pace from tightening to unfolding,the optimal crease distribution patterns for four irregular(‘N’-,‘T’-,‘O’-,and‘P’-shaped)origami configurations are then presented under five candidates.When the dimensions of the origami are fixed,it is discovered that simpler folding patterns lead to faster deformation of the origami configuration.When the folding complexity is fixed,higher strain energy results in more rapid origami expansion.展开更多
Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate vario...Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate various computational tools,including machine learning,molecular dynamic simulation and physiologically based absorption modeling(PBAM),to enhance andrographolide(AG)/cyclodextrins(CDs)formulation design.The light GBM prediction model we built before was utilized to predict AG/CDs inclusion's binding free energy.AG/γ-CD inclusion complexes showed the strongest binding affinity,which was experimentally validated by the phase solubility study.The molecular dynamic simulation was used to investigate the inclusion mechanism between AG andγ-CD,which was experimentally characterized by DSC,FTIR and NMR techniques.PBAM was applied to simulate the in vivo behavior of the formulations,which were validated by cell and animal experiments.Cell experiments revealed that the presence of D-α-Tocopherol polyethylene glycol succinate(TPGS)significantly increased the intracellular uptake of AG in MDCKMDR1 cells and the absorptive transport of AG in MDCK-MDR1 monolayers.The relative bioavailability of the AG-CD-TPGS ternary system in rats was increased to 2.6-fold and 1.59-fold compared with crude AG and commercial dropping pills,respectively.In conclusion,this is the first time to integrate various computational tools to develop a new AG-CD-TPGS ternary formulation with significant improvement of aqueous solubility,dissolution rate and bioavailability.The integrated computational tool is a novel and robust methodology to facilitate pharmaceutical formulation design.展开更多
A simulation tool named BITSIM orienting production engineering is developed in order to improve enterprise＇s productivity and making up the scarcity of computer application. The architecture of BITSIM is presented f...A simulation tool named BITSIM orienting production engineering is developed in order to improve enterprise＇s productivity and making up the scarcity of computer application. The architecture of BITSIM is presented first. Hierarchical technique, control strategy based on multi-agent and simulation output analysis are depicted in detail then. In the end, an application example is taken out to prove that this system could be used to analyzing different hypothetical situation and configuring the auxiliary manufacturing system before production.展开更多
In tropical regions,heavy rainfall induces erosion and shallow landslides on road embankments.Cement-based stabilization methods,common in these regions,contribute to climate change due to their high carbon footprint....In tropical regions,heavy rainfall induces erosion and shallow landslides on road embankments.Cement-based stabilization methods,common in these regions,contribute to climate change due to their high carbon footprint.This study explored the potential application of coir fiber-reinforced laterite soil-bottom ash mixtures as embankment materials in the tropics.The objective is to enhance engineered embankment slopes'erosion resistance and stability while offering reuse options for industrial byproducts.This study examined various mix designs for unconfined compressive strength(UCS)and permeability,utilizing 30%bottom ash(BA)and 1%coir fiber(CF)with varying sizes ranging from 10 to 40 mm,6%lime,and laterite soil(LS),followed by microstructural analyses.The results demonstrate that the compressive strength increases as the CF length increases to 25 mm.In contrast,permeability increases continuously with increasing CF length.Lime-treated mixtures exhibit superior short-and long-term strength and reduce permeability owing to the formation of cementitious materials,as confirmed by microstructural analyses.A lab-scale slope box was constructed to evaluate the surface erosion of the stabilized laterite soil embankment.Based on the rainfall simulation results,the LS-BA-CF mixtures show better resistance to erosion and deformation compared to untreated LS,especially when lime is added to the top layer.This study provides insights into a sustainable and cost-effective approach for slope stabilization using BA and CF,offering a promising solution for tropical regions susceptible to surface erosion and landslides.展开更多
This paper presents an investigation into the impact of proton-induced alteration of carrier lifetime on the singleevent transient(SET) caused by heavy ions in silicon–germanium heterojunction bipolar transistor(SiGe...This paper presents an investigation into the impact of proton-induced alteration of carrier lifetime on the singleevent transient(SET) caused by heavy ions in silicon–germanium heterojunction bipolar transistor(SiGe HBT).The ioninduced current transients and integrated charge collections under different proton fluences are obtained based on technology computer-aided design(TCAD) simulation.The results indicate that the impact of carrier lifetime alteration is determined by the dominating charge collection mechanism at the ion incident position and only the long-time diffusion process is affected.With a proton fluence of 5 × 1013 cm-2, almost no change is found in the transient feature, and the charge collection of events happened in the region enclosed by deep trench isolation(DTI), where prompt funneling collection is the dominating mechanism.Meanwhile, for the events happening outside DTI where diffusion dominates the collection process, the peak value and the duration of the ion-induced current transient both decrease with increasing proton fluence, leading to a great decrease in charge collection.展开更多
SWAT model is one of the primary tools for assessing irrigation district water management and water-saving measures.However,its incapacity to consider the diverse growth and water requirements of paddy during various ...SWAT model is one of the primary tools for assessing irrigation district water management and water-saving measures.However,its incapacity to consider the diverse growth and water requirements of paddy during various growth stages,as well as the insufficient availability of external water sources.This study introduces the Penman-Monteith equation and Jensen model into the SWAT framework,setting crop coefficients,crop base coefficients,and growth stage sensitivity indices based on the different growth stage.Additionally,modifications are made to the external water source available for irrigation and paddyfield leakage modules,establishing a distributed agricultural hydrological model suitable for accurately simulating water balance elements and paddy yield in multi-source irrigation districts.The Yangshudang watershed in the Zhanghe irrigation district is chosen for the evaluation of the modified model's simulation performance,with a quantitative assessment of water-saving and yield-increasing effects.The results demonstrate that the modified model effectively meets the requirements for simulating paddy evapotranspiration of various growth stages,yield,agricultural irrigation water consumptions,and runoff,exhibiting a notable enhancement in performance.As two common water-saving measures in irrigation areas,inter-mittent irrigation and irrigation district renovation were used as two water-saving scenarios in the simulation of the modified SWAT model.Under intermittent irrigation,the watershed experiences a 6.58%reduction in net irrigation water use.In the scenario with irrigation district renovation,the water resources in the watershed are utilized more efficiently.The modified model from this study can be applied for assessing the synergistic effects of irrigation district water-saving and yield-increasing measures,providing crucial insights for the formulation of irri-gation district water-saving strategies and water resource optimization plans.展开更多
文摘This study evaluates the Fuzzy Analytical Hierarchy Process(FAHP)as a multi-criteria decision(MCD)support tool for selecting appropriate additive manufacturing(AM)techniques that align with cleaner production and environmental sustainability.The FAHP model was validated using an example of the production of aircraft components(specifically fuselage)employing AM technologies such as Wire Arc Additive Manufacturing(WAAM),laser powder bed fusion(L-PBF),Binder Jetting(BJ),Selective Laser Sintering(SLS),and Laser Metal Deposition(LMD).The selection criteria prioritized eco-friendly manufacturing considerations,including the quality and properties of the final product(e.g.,surface finish,high strength,and corrosion resistance),service and functional requirements,weight reduction for improved energy efficiency(lightweight structures),and environmental responsibility.Sustainability metrics,such as cost-effectiveness,material efficiency,waste minimization,and environmental impact,are central to the evaluation process.A computer-aided modeling approach was also used to simulate the performance of aluminum(AA7075 T6),steel(304),and titanium alloy(Ti6Al4V)for fuselage development.The results demonstrate that MCD approaches such as FAHP can effectively guide the selection of AM technologies that meet functional and technical requirements while minimizing environmental degradation footprints.Furthermore,the aluminumalloy outperformed the other materials investigated in the simulation with the lowest stress concentration and least deformation.This study contributes to advancing cleaner production practices by providing a decision-making framework for sustainable and eco-friendly manufacturing,enabling manufacturers to adopt AM technologies that promote environmental responsibility and sustainable development,while maintaining product quality and performance.
基金supported by the National Natural Science Foundation of China 11821202(Xu Guo)the National Key Research and Development Plan 2020YFB1709401(Xu Guo)the Liaoning Revitalization Talents Program XLYC2001003(Xu Guo)。
文摘Most existing treatments for origami-folding simulations have focused on regular-shaped configurations.This article aims to introduce a general strategy for simulating and analyzing the deformation process of irregular shapes by means of computational capabilities nowadays.To better simulate origami deformation with folding orders,the concept of plane follow-up is introduced to achieve automated computer simulation of complex folding patterns,thereby avoiding intersection and penetration between planes.Based on the evaluation criteria such as the lowest storage energy with tightening and the fastest pace from tightening to unfolding,the optimal crease distribution patterns for four irregular(‘N’-,‘T’-,‘O’-,and‘P’-shaped)origami configurations are then presented under five candidates.When the dimensions of the origami are fixed,it is discovered that simpler folding patterns lead to faster deformation of the origami configuration.When the folding complexity is fixed,higher strain energy results in more rapid origami expansion.
基金financially supported by the FDCT Project 0029/2018/A1the University of Macao Research Grants(MYRG2019-00041-ICMS)performed in part at the High-Performance Computing Cluster(HPCC)which is supported by Information and Communication Technology Office(ICTO)of the University of Macao。
文摘Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate various computational tools,including machine learning,molecular dynamic simulation and physiologically based absorption modeling(PBAM),to enhance andrographolide(AG)/cyclodextrins(CDs)formulation design.The light GBM prediction model we built before was utilized to predict AG/CDs inclusion's binding free energy.AG/γ-CD inclusion complexes showed the strongest binding affinity,which was experimentally validated by the phase solubility study.The molecular dynamic simulation was used to investigate the inclusion mechanism between AG andγ-CD,which was experimentally characterized by DSC,FTIR and NMR techniques.PBAM was applied to simulate the in vivo behavior of the formulations,which were validated by cell and animal experiments.Cell experiments revealed that the presence of D-α-Tocopherol polyethylene glycol succinate(TPGS)significantly increased the intracellular uptake of AG in MDCKMDR1 cells and the absorptive transport of AG in MDCK-MDR1 monolayers.The relative bioavailability of the AG-CD-TPGS ternary system in rats was increased to 2.6-fold and 1.59-fold compared with crude AG and commercial dropping pills,respectively.In conclusion,this is the first time to integrate various computational tools to develop a new AG-CD-TPGS ternary formulation with significant improvement of aqueous solubility,dissolution rate and bioavailability.The integrated computational tool is a novel and robust methodology to facilitate pharmaceutical formulation design.
文摘A simulation tool named BITSIM orienting production engineering is developed in order to improve enterprise＇s productivity and making up the scarcity of computer application. The architecture of BITSIM is presented first. Hierarchical technique, control strategy based on multi-agent and simulation output analysis are depicted in detail then. In the end, an application example is taken out to prove that this system could be used to analyzing different hypothetical situation and configuring the auxiliary manufacturing system before production.
文摘In tropical regions,heavy rainfall induces erosion and shallow landslides on road embankments.Cement-based stabilization methods,common in these regions,contribute to climate change due to their high carbon footprint.This study explored the potential application of coir fiber-reinforced laterite soil-bottom ash mixtures as embankment materials in the tropics.The objective is to enhance engineered embankment slopes'erosion resistance and stability while offering reuse options for industrial byproducts.This study examined various mix designs for unconfined compressive strength(UCS)and permeability,utilizing 30%bottom ash(BA)and 1%coir fiber(CF)with varying sizes ranging from 10 to 40 mm,6%lime,and laterite soil(LS),followed by microstructural analyses.The results demonstrate that the compressive strength increases as the CF length increases to 25 mm.In contrast,permeability increases continuously with increasing CF length.Lime-treated mixtures exhibit superior short-and long-term strength and reduce permeability owing to the formation of cementitious materials,as confirmed by microstructural analyses.A lab-scale slope box was constructed to evaluate the surface erosion of the stabilized laterite soil embankment.Based on the rainfall simulation results,the LS-BA-CF mixtures show better resistance to erosion and deformation compared to untreated LS,especially when lime is added to the top layer.This study provides insights into a sustainable and cost-effective approach for slope stabilization using BA and CF,offering a promising solution for tropical regions susceptible to surface erosion and landslides.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11775167,61574171,11575138,and 11835006)
文摘This paper presents an investigation into the impact of proton-induced alteration of carrier lifetime on the singleevent transient(SET) caused by heavy ions in silicon–germanium heterojunction bipolar transistor(SiGe HBT).The ioninduced current transients and integrated charge collections under different proton fluences are obtained based on technology computer-aided design(TCAD) simulation.The results indicate that the impact of carrier lifetime alteration is determined by the dominating charge collection mechanism at the ion incident position and only the long-time diffusion process is affected.With a proton fluence of 5 × 1013 cm-2, almost no change is found in the transient feature, and the charge collection of events happened in the region enclosed by deep trench isolation(DTI), where prompt funneling collection is the dominating mechanism.Meanwhile, for the events happening outside DTI where diffusion dominates the collection process, the peak value and the duration of the ion-induced current transient both decrease with increasing proton fluence, leading to a great decrease in charge collection.
基金Fundamental Research Funds for Central Public Welfare Research Institutes,Grant/Award Number:CKSA2023479/NYNSFC-MWR-CTGC Joint Yangtze River Water Science Research Project,Grant/Award Number:U2040213+1 种基金Basic Scientific Research Business Funding Projects of Central Public Welfare Research Institutes,Grant/Award Numbers:CKSF2019251/NY,CKSF2021299/NYProjects of International Cooperation and Exchanges NSFC,Grant/Award Number:52211540722。
文摘SWAT model is one of the primary tools for assessing irrigation district water management and water-saving measures.However,its incapacity to consider the diverse growth and water requirements of paddy during various growth stages,as well as the insufficient availability of external water sources.This study introduces the Penman-Monteith equation and Jensen model into the SWAT framework,setting crop coefficients,crop base coefficients,and growth stage sensitivity indices based on the different growth stage.Additionally,modifications are made to the external water source available for irrigation and paddyfield leakage modules,establishing a distributed agricultural hydrological model suitable for accurately simulating water balance elements and paddy yield in multi-source irrigation districts.The Yangshudang watershed in the Zhanghe irrigation district is chosen for the evaluation of the modified model's simulation performance,with a quantitative assessment of water-saving and yield-increasing effects.The results demonstrate that the modified model effectively meets the requirements for simulating paddy evapotranspiration of various growth stages,yield,agricultural irrigation water consumptions,and runoff,exhibiting a notable enhancement in performance.As two common water-saving measures in irrigation areas,inter-mittent irrigation and irrigation district renovation were used as two water-saving scenarios in the simulation of the modified SWAT model.Under intermittent irrigation,the watershed experiences a 6.58%reduction in net irrigation water use.In the scenario with irrigation district renovation,the water resources in the watershed are utilized more efficiently.The modified model from this study can be applied for assessing the synergistic effects of irrigation district water-saving and yield-increasing measures,providing crucial insights for the formulation of irri-gation district water-saving strategies and water resource optimization plans.
