BACKGROUND Artificial intelligence in radiology has the potential to assist with the diagnosis,prognostication and therapeutic response prediction of various cancers.A few studies have reported that texture analysis c...BACKGROUND Artificial intelligence in radiology has the potential to assist with the diagnosis,prognostication and therapeutic response prediction of various cancers.A few studies have reported that texture analysis can be helpful in predicting the response to chemotherapy for colorectal liver metastases,however,the results have varied.Necrotic metastases were not clearly excluded in these studies and in most studies the full range of texture analysis features were not evaluated.This study was designed to determine if the computed tomography(CT)texture analysis results of non-necrotic colorectal liver metastases differ from previous reports.A larger range of texture features were also evaluated to identify potential new biomarkers.AIM To identify potential new imaging biomarkers with CT texture analysis which can predict the response to first-line cytotoxic chemotherapy in non-necrotic colorectal liver metastases(CRLMs).METHODS Patients who presented with CRLMs from 2012 to 2020 were retrospectively selected on the institutional radiology information system of our private radiology practice.The inclusion criteria were non-necrotic CRLMs with a minimum size of 10 mm(diagnosed on archived 1.25 mm portal venous phase CT(FOLFOX,FOLFIRI,FOLFOXIRI,CAPE-OX,CAPE-IRI or capecitabine).The final study cohort consisted of 29 patients.The treatment response of the CRLMs was classified according to the RECIST 1.1 criteria.By means of CT texture analysis,various first and second order texture features were extracted from a single nonnecrotic target CRLM in each responding and non-responding patient.Associations between features and response to chemotherapy were assessed by logistic regression models.The prognostic accuracy of selected features was evaluated by using the area under the curve.RESULTS There were 15 responders(partial response)and 14 non-responders(7 stable and 7 with progressive disease).The responders presented with a higher number of CRLMs(P=0.05).In univariable analysis,eight texture features of the responding CRLMs were associated with treatment response,but due to strong correlations among some of the features,only two features,namely minimum histogram gradient intensity and long run low grey level emphasis,were included in the multiple analysis.The area under the receiver operating characteristic curve of the multiple model was 0.80(95%CI:0.64 to 0.96),with a sensitivity of 0.73(95%CI:0.48 to 0.89)and a specificity of 0.79(95%CI:0.52 to 0.92).CONCLUSION Eight first and second order texture features,but particularly minimum histogram gradient intensity and long run low grey level emphasis are significantly correlated with treatment response in non-necrotic CRLMs.展开更多
Thoracic reconstructions are essential surgical techniques used to replace severely damaged tissues and restore protection to internal organs.In recent years,advancements in additive manufacturing have enabled the pro...Thoracic reconstructions are essential surgical techniques used to replace severely damaged tissues and restore protection to internal organs.In recent years,advancements in additive manufacturing have enabled the production of thoracic implants with complex geometries,offering more versatile performance.In this study,we investigated a design based on a spring-like geometry manufactured by laser powder bed fusion(LPBF),as proposed in earlier research.The biomechanical behavior of this design was analyzed using various isolated semi-ring-rib models at different levels of the rib cage.This approach enabled a comprehensive examination,leading to the proposal of several implant configurations that were incorporated into a 3D rib cage model with chest wall defects,to simulate different chest wall reconstruction scenarios.The results revealed that the implant design was too rigid for the second rib level,which therefore was excluded from the proposed implant configurations.In chest wall reconstruction simulations,the maximum stresses observed in all prostheses did not exceed 38%of the implant material's yield stress in the most unfavorable case.Additionally,all the implants showed flexibility compatible with the physiological movements of the human thorax.展开更多
Based on BERTopic Model,the paper combines qualitative and quantitative methods to explore the reception of Can Xue’s translated works by analyzing readers’book reviews posted on Goodreads and Lovereading.We first c...Based on BERTopic Model,the paper combines qualitative and quantitative methods to explore the reception of Can Xue’s translated works by analyzing readers’book reviews posted on Goodreads and Lovereading.We first collected book reviews from these two well-known websites by Python.Through topic analysis of these reviews,we identified recurring topics,including details of her translated works and appreciation of their translation quality.Then,employing sentiment and content analysis methods,the paper explored the emotional attitudes and the specific thoughts of readers toward Can Xue and her translated works.The fingdings revealed that,among the 408 reviews,though the reception of Can Xue’s translated works was relatively positive,the current level of attention and recognition remains insufficient.However,based on the research results,the paper can derive valuable insights into the translation and dissemination processes such as adjusting translation and dissemination strategies,so that the global reach of Chinese literature and culture can be better facilitated.展开更多
Objective To examine the important roles of microRNAs （miRNAs） in regulating amphid structure and function, we performed a computational analysis for the genetic loci required for the sensory perception and their po...Objective To examine the important roles of microRNAs （miRNAs） in regulating amphid structure and function, we performed a computational analysis for the genetic loci required for the sensory perception and their possibly corresponding miRNAs in C. elegans. Methods Total 55 genetic loci required for the amphid structure and function were selected. Sequence alignment was combined with E value evaluation to investigate and identify the possible corresponding miRNAs. Results Total 30 genes among the 55 genetic loci selected have their possible corresponding regulatory miRNA（s）, and identified genes participate in the regulation of almost all aspects of amphid structure and function. In addition, our data suggest that both the amphid structure and the amphid functions might be regulated by a series of network signaling pathways. Moreover, the distribution of miRNAs along the 3＇ untranslated region （UTR） of these 30 genes exhibits different patterns. Conclusion We present the possible miRNA-mediated signaling pathways involved in the regulation of chemosensation and thermosensation by controlling the corresponding sensory neuron and interneuron functions. Our work will be useful for better understanding of the miRNA-mediated control of the chemotaxis and thermotaxis in C. elegans.展开更多
Objective To elucidate the important functions of microRNAs （miRNAs） in regulating synaptic assembly and function, we performed a computational analysis for the genetic loci required for the synaptic structure and f...Objective To elucidate the important functions of microRNAs （miRNAs） in regulating synaptic assembly and function, we performed a computational analysis for the genetic loci required for the synaptic structure and function and their corresponding miRNAs in C. elegans. Methods Total 198 genetic loci required for the synaptic structure and function were selected. Sequence alignment was combined with E value evaluation to investigate and identify the possible corresponding miRNAs. Results Total 163 genes among the 198 genetic loci selected have their possibly corresponding regulatory miRNA （s）, which covered most of the important genetic loci required for the synaptic structure and function. Moreover, only 22 genes among the analyzed 38 genetic loci encoding synaptic proteins have more possibility to under the control of non-coding RNA genes. In addition, the distribution of miRNAs along the 3＇ untranslated region （UTR） of these 22 genes exhibits different patterns. Condusion Here we provide the computational screen and analysis results for the genetic loci required for synaptic structure and function and their possible corresponding miRNAs. These data will be useful for the further attempt to systematically determine the roles of miRNAs in synaptic assembly and function regulation in worms.展开更多
An empirical expression of cohesion （C） and friction angle （Ф） for layered rock was suggested. This expression was compared with a test result made by the former researchers. The constitutive relationship of a tr...An empirical expression of cohesion （C） and friction angle （Ф） for layered rock was suggested. This expression was compared with a test result made by the former researchers. The constitutive relationship of a transversely isotropic medium and Mohr-Coulomb criterion in which C and Ф vary with directions were employed, and a relative 3D elasto-plastic FEM code was developed, in which the important thing was to adopt a search-trial method to find the orientation angle （p） of shear failure plane （or weakest shear plane） with respect to the major principal stress as well as the corresponding C and Ф Taking an underground opening as the calculation object, the numerical analyses were carried out by using the FEM code for two cases of transversely isotropic rock and isotropic rock, respectively, and the computation results were compared. The results show that when the rock is a transversely isotropic one, the distributions of displacements, plastic zones and stress contours in the surrounding rock will be non-axisymmetric along the tunnel＇s vertical axis, which is very different from that of isotropic rock. The stability of the tunnel in transversely isotropic rock is relatively low.展开更多
Application of nanofluids in heat pipes usually presents satisfactory experimental results regarding a thermal resistance reduction of the heat pipe.However,the existing computational studies connecting heat pipes and...Application of nanofluids in heat pipes usually presents satisfactory experimental results regarding a thermal resistance reduction of the heat pipe.However,the existing computational studies connecting heat pipes and nanofluids lack a deeper discussion regarding the validity of the models currently used for representing the behaviour of a nanofluid in a heat pipe,particularly for unusual base fluids and nanoparticles such as carbon nanotubes or ethylene glycol.Thus,this comparative study presents the results of a set of computational simulations using pre-established equations for modelling a nanofluid in a heat pipe with experimental data from the literature.The results show agreement with the expected behaviour qualitatively and the presented maximum variations between 1.5% and 23.9% in comparison to the experimentally measured average temperatures.Also,the experimentally obtained temperature distribution of a heat pipe could not be reached numerically only with the use of adequate thermal properties,indicating that the boiling phenomenon is more complex than the current model used for computational simulations.Moreover,the existence of an optimal particle volume fraction for using nanofluids in this application could be observed by combining different properties models.展开更多
In this paper, we investigate the properties of an alternative material for use in marine engineering, namely a rigid and light sandwich-structured composite made of expanded polystyrene and fiberglass. Not only does ...In this paper, we investigate the properties of an alternative material for use in marine engineering, namely a rigid and light sandwich-structured composite made of expanded polystyrene and fiberglass. Not only does this material have an improved section modulus, but it is also inexpensive, light, easy to manipulate, and commercially available in various sizes. Using a computer program based on the finite element method, we calculated the hogging and sagging stresses and strains acting on a prismatic boat model composed of this material, and determined the minimum sizes and maximum permissible stresses to avoid deformation. Finally, we calculated the structural weight of the resulting vessel for comparison with another structure of comparable dimensions constructed from the commonly used core material Divinycell.展开更多
Shrinkage cavity may be detrimental to mechanical performances of casting parts.As a consequence,design engineers often use overly large safety factors in many designs due to insufficient understanding of quantitative...Shrinkage cavity may be detrimental to mechanical performances of casting parts.As a consequence,design engineers often use overly large safety factors in many designs due to insufficient understanding of quantitative effects of shrinkage cavity defects.In this paper,process of Al alloy wheel impact test was computationally analyzed for both the wheel models with and without shrinkage cavity defects.Based on shrinkage cavity data obtained from industrial CT (Computerized Tomography),the shrinkage cavity defects were modeled with SSM (Shape Simplification Method),which reconstructs shrinkage cavity defects to hollow spheroid primitives.After the impact simulation was conducted,the results show that under impact test condition,the wheel considering shrinkage cavity defects may fracture while the sound-assumed wheel may not.展开更多
This paper deals with system engineering and design methodology for super low altitude satel ites in the view of the com-putational mission analysis. Due to the slight advance of imaging instruments, such as the focus...This paper deals with system engineering and design methodology for super low altitude satel ites in the view of the com-putational mission analysis. Due to the slight advance of imaging instruments, such as the focus of camera and the image element of charge coupled device （CCD）, it is an innovative and economical way to improve the camera’s resolution to enforce the satel ite to fly on the lower altitude orbit. DFH-3, the mature satel ite bus de-veloped by Chinese Academy of Space Technology, is employed to define the mass and power budgets for the computational mis-sion analysis and the detailed engineering design for super low altitude satel ites. An effective iterative algorithm is proposed to solve the ergodic representation of feasible mass and power bud-gets at the flight altitude under constraints. Besides, boundaries of mass or power exist for every altitude, where the upper boundary is derived from the maximum power, while the minimum thrust force holds the lower boundary before the power reaching the initial value. What’s more, an analytical algorithm is employed to numerical y investigate the coverage percentage over the altitude, so that the nominal altitude could be selected from al the feasi-ble altitudes based on both the mass and power budgets and the repetitive ground traces. The local time at the descending node is chosen for the nominal sun-synchronous orbit based on the average evaluation function. After determining the key orbital ele-ments based on the computational mission analysis, the detailed engineering design on the configuration and other subsystems, like power, telemetry telecontrol and communication （TT＆amp;C）, and attitude determination and control system （ADCS）, is performed based on the benchmark bus, besides, some improvements to the bus are also implemented to accommodate the flight at a super low altitude. Two operation strategies, drag-free closed-loop mode and on/off open-loop mode, are presented to maintain the satel-lite’s altitude. Final y, a flight planning schedule for the satel ite is demonstrated from its launch into the initial altitude at the very beginning to its decay to death in the end.展开更多
The fast-growing demand of computational fluid dynamics（CFD） application for computing resources stimulates the development of high performance computing（HPC） and meanwhile raises new requirements for the technolo...The fast-growing demand of computational fluid dynamics（CFD） application for computing resources stimulates the development of high performance computing（HPC） and meanwhile raises new requirements for the technology of parallel application performance monitor and analysis.In response to large-scale and long-time running for the application of CFD,online and scalable performance analysis technology is required to optimize the parallel programs as well as to improve their operational efficiency.As a result,this research implements a scalable infrastructure for online performance analysis on CFD application with homogeneous or heterogeneous system.The infrastructure is part of the parallel application performance monitor and analysis system（PAPMAS） and is composed of two modules which are scalable data transmission module and data storage module.The paper analyzes and elaborates this infrastructure in detail with respect to its design and implementation.Furthermore,some experiments are carried out to verify the rationality and high efficiency of this infrastructure that could be adopted to meet the practical needs.展开更多
Elegans are one of the best model organisms in neural researches, and tropism movement is a typical learning and memorizing activity. Based on one imaging technique called Fast Track-Capturing Microscope (FTCM), we in...Elegans are one of the best model organisms in neural researches, and tropism movement is a typical learning and memorizing activity. Based on one imaging technique called Fast Track-Capturing Microscope (FTCM), we investigated the movement regulation. Two movement patterns are extracted from various trajectories through analysis on turning angle. Then we applied this classification on trajectory regulation on the compound gradient field, and theoretical results corresponded with experiments well, which can initially verify the conclusion. Our breakthrough is performed computational geometric analysis on trajectories. Several independent features were combined to describe movement properties by principal composition analysis (PCA) and support vector machine (SVM). After normalizing all data sets, no-supervising machine learning was processed along with some training under certain supervision. The final classification results performed perfectly, which indicates the further application of such computational analysis in biology researches combining with machine learning.展开更多
A framework for accelerating modern long-running astrophysical simulations is presented, which is based on a hierarchical architecture where computational steering in the high-resolution run is performed under the gui...A framework for accelerating modern long-running astrophysical simulations is presented, which is based on a hierarchical architecture where computational steering in the high-resolution run is performed under the guide of knowledge obtained in the gradually refined ensemble analyses. Several visualization schemes for facilitating ensemble management, error analysis, parameter grouping and tuning are also integrated owing to the pluggable modular design. The proposed approach is prototyped based on the Flash code, and it can be extended by introducing userdefined visualization for specific requirements. Two real-world simulations, i.e., stellar wind and supernova remnant, are carried out to verify the proposed approach.展开更多
Disordered ferromagnets with a domain structure that exhibit a hysteresis loop when driven by the external magnetic field are essential materials for modern technological applications.Therefore,the understanding and p...Disordered ferromagnets with a domain structure that exhibit a hysteresis loop when driven by the external magnetic field are essential materials for modern technological applications.Therefore,the understanding and potential for controlling the hysteresis phenomenon in thesematerials,especially concerning the disorder-induced critical behavior on the hysteresis loop,have attracted significant experimental,theoretical,and numerical research efforts.We review the challenges of the numerical modeling of physical phenomena behind the hysteresis loop critical behavior in disordered ferromagnetic systems related to the non-equilibriumstochastic dynamics of domain walls driven by external fields.Specifically,using the extended Random Field Ising Model,we present different simulation approaches and advanced numerical techniques that adequately describe the hysteresis loop shapes and the collective nature of the magnetization fluctuations associated with the criticality of the hysteresis loop for different sample shapes and varied parameters of disorder and rate of change of the external field,as well as the influence of thermal fluctuations and demagnetizing fields.The studied examples demonstrate how these numerical approaches reveal newphysical insights,providing quantitativemeasures of pertinent variables extracted from the systems’simulated or experimentally measured Barkhausen noise signals.The described computational techniques using inherent scale-invariance can be applied to the analysis of various complex systems,both quantum and classical,exhibiting non-equilibrium dynamical critical point or self-organized criticality.展开更多
Inertial navigation system/visual navigation system(INS/VNS) integrated navigation is a commonly used autonomous navigation method for planetary rovers. Since visual measurements are related to the previous and curren...Inertial navigation system/visual navigation system(INS/VNS) integrated navigation is a commonly used autonomous navigation method for planetary rovers. Since visual measurements are related to the previous and current state vectors(position and attitude) of planetary rovers, the performance of the Kalman filter(KF) will be challenged by the time-correlation problem. A state augmentation method, which augments the previous state value to the state vector, is commonly used when dealing with this problem. However, the augmenting of state dimensions will result in an increase in computation load. In this paper, a state dimension reduced INS/VNS integrated navigation method based on coordinates of feature points is presented that utilizes the information obtained through INS/VNS integrated navigation at a previous moment to overcome the time relevance problem and reduce the dimensions of the state vector. Equations of extended Kalman filter(EKF) are used to demonstrate the equivalence of calculated results between the proposed method and traditional state augmented methods. Results of simulation and experimentation indicate that this method has less computational load but similar accuracy when compared with traditional methods.展开更多
The meaning to research the potential of VLBI for geodetic applications is summarized. And the observation models and their related parameters of geodetic interest are investigated. Then, the principle and method of u...The meaning to research the potential of VLBI for geodetic applications is summarized. And the observation models and their related parameters of geodetic interest are investigated. Then, the principle and method of using the random model in VLBI data processing are investigated. With the world wide VLBI data from 2000-2004, the conditions to compute the parameters of geodetic interest are introduced, and so are the computing methods and processes. And the computed resuits of the parameters of geodetic interest are analyzed.展开更多
Adenylyl cyclases (ACs) are a special group of enzymes that catalyze formation of the second messenger molecule, 3',5'-cyclic adenosine monophosphate (cAMP) from 5'-adenosine triphosphate (ATP). Apparently...Adenylyl cyclases (ACs) are a special group of enzymes that catalyze formation of the second messenger molecule, 3',5'-cyclic adenosine monophosphate (cAMP) from 5'-adenosine triphosphate (ATP). Apparently, even though cAMP is increasingly becoming an important signaling molecule in higher plants, the identification of plant ACs has somewhat remained slow. Here we report the recombinant cloning, partial expression and affinity purification of the truncated version (AtAC<sup>261-388</sup>) of a putative Arabidopsis thaliana protein (AtAC: At3g21465) followed by a demonstration of its inherent enzymatic activity as an AC. Currently, AtAC is not assigned any particular function in A. thaliana but simply annotated as an AC-like protein and, therefore, we targeted it for our study to establish if it is indeed a bona fide AC molecule. From our work, we firstly, show through enzyme immunoassaying and mass spectrometry that the recombinant AtAC<sup>261-388</sup><sub> </sub>can generate cAMP from ATP in vitro in a manganese-dependent manner that is activated by calcium and hydrogen carbonate. Secondly, we reveal through computational analysis that the AC center of AtAC is solvent-exposed, and amenable to the unhindered access of ATP as a substrate for catalysis. Lastly, we show that the recombinant AtAC<sup>261-388</sup> can complement AC-deficiency (cyaA mutation) in SP850 cells when expressed in this mutant Escherichia coli strain.展开更多
Objective:Wallerian degeneration is a pathological process closely related to peripheral nerve regeneration following injury,and includes the disintegration and phagocytosis of peripheral nervous system cells.Traditio...Objective:Wallerian degeneration is a pathological process closely related to peripheral nerve regeneration following injury,and includes the disintegration and phagocytosis of peripheral nervous system cells.Traditionally,morphological changes are observed by performing immunofluorescence staining after sectioning,which results in the loss of some histological information.The purpose of this study was to explore a new,nondestmetive,and systematic method for observing axonal histological changes during Wallerian degeneration.Methods:Thirty male Thy1-YFP-16 mice(SPF grade,6 weeks old,20±5 g)were randomly selected and divided into clear,unobstructed brain imaging cocktails and computational analysis(CUBIC)optical clearing(n=15)and traditional method groups(n=15).Five mice in each group were sacrificed at 1st,3rd,and 5th day following a crush operation.The histological axon changes were observed by CUBIC light optical clearing treatment,direct tissue section imaging,and HE staining.Results:The results revealed that,compared with traditional imaging methods,there was no physical damage to the samples,which allowed for three-dimensional and deep-seated tissue imaging through CUBIC.Local image information could be nicely obtained by direct fluorescence imaging and HE staining,but it was difficult to obtain image information of the entire sample.At the same time,the image information obtained by fluorescence imaging and HE staining was partially lost.Conclusion:The combining of CUBIC and Thy1-YFP transgenic mice allowed for a clear and comprehensive observation of histological changes of axons in Wallerian degeneration.展开更多
The mixed-metal cluster Yb4O4（OiPr）16Na12 has been synthesized and structurally determined by IR, elemental analysis, and single-crystal X-ray diffraction. The crystal belongs to the cubic system, space group P23 wi...The mixed-metal cluster Yb4O4（OiPr）16Na12 has been synthesized and structurally determined by IR, elemental analysis, and single-crystal X-ray diffraction. The crystal belongs to the cubic system, space group P23 with a = b = c = 13.9788（3）A, V = 2731.55（10）A3, Z = 1, Dc = 1.202 g/cm3, Mr = 1977.42,/J = 3.480 mm-1, F（000） = 972, the final R = 0.0288 and wR = 0.1511 for 1677 observed reflections with I 〉 2σ（I）. X-ray analysis reveals that Yb4O4（Oipr）16Na12 is centrosym- metric and the structure contains four ytterbium metals and twelve sodium metals, and each ytterbium atom is coordinated by six oxygen atoms. In addition, an ancillary computational analysis of the optimized molecular unit was provided. The large energy gap （3,31 eV） between HOMO and LUMO indicates that the structure framework is particularly stable.展开更多
文摘BACKGROUND Artificial intelligence in radiology has the potential to assist with the diagnosis,prognostication and therapeutic response prediction of various cancers.A few studies have reported that texture analysis can be helpful in predicting the response to chemotherapy for colorectal liver metastases,however,the results have varied.Necrotic metastases were not clearly excluded in these studies and in most studies the full range of texture analysis features were not evaluated.This study was designed to determine if the computed tomography(CT)texture analysis results of non-necrotic colorectal liver metastases differ from previous reports.A larger range of texture features were also evaluated to identify potential new biomarkers.AIM To identify potential new imaging biomarkers with CT texture analysis which can predict the response to first-line cytotoxic chemotherapy in non-necrotic colorectal liver metastases(CRLMs).METHODS Patients who presented with CRLMs from 2012 to 2020 were retrospectively selected on the institutional radiology information system of our private radiology practice.The inclusion criteria were non-necrotic CRLMs with a minimum size of 10 mm(diagnosed on archived 1.25 mm portal venous phase CT(FOLFOX,FOLFIRI,FOLFOXIRI,CAPE-OX,CAPE-IRI or capecitabine).The final study cohort consisted of 29 patients.The treatment response of the CRLMs was classified according to the RECIST 1.1 criteria.By means of CT texture analysis,various first and second order texture features were extracted from a single nonnecrotic target CRLM in each responding and non-responding patient.Associations between features and response to chemotherapy were assessed by logistic regression models.The prognostic accuracy of selected features was evaluated by using the area under the curve.RESULTS There were 15 responders(partial response)and 14 non-responders(7 stable and 7 with progressive disease).The responders presented with a higher number of CRLMs(P=0.05).In univariable analysis,eight texture features of the responding CRLMs were associated with treatment response,but due to strong correlations among some of the features,only two features,namely minimum histogram gradient intensity and long run low grey level emphasis,were included in the multiple analysis.The area under the receiver operating characteristic curve of the multiple model was 0.80(95%CI:0.64 to 0.96),with a sensitivity of 0.73(95%CI:0.48 to 0.89)and a specificity of 0.79(95%CI:0.52 to 0.92).CONCLUSION Eight first and second order texture features,but particularly minimum histogram gradient intensity and long run low grey level emphasis are significantly correlated with treatment response in non-necrotic CRLMs.
文摘Thoracic reconstructions are essential surgical techniques used to replace severely damaged tissues and restore protection to internal organs.In recent years,advancements in additive manufacturing have enabled the production of thoracic implants with complex geometries,offering more versatile performance.In this study,we investigated a design based on a spring-like geometry manufactured by laser powder bed fusion(LPBF),as proposed in earlier research.The biomechanical behavior of this design was analyzed using various isolated semi-ring-rib models at different levels of the rib cage.This approach enabled a comprehensive examination,leading to the proposal of several implant configurations that were incorporated into a 3D rib cage model with chest wall defects,to simulate different chest wall reconstruction scenarios.The results revealed that the implant design was too rigid for the second rib level,which therefore was excluded from the proposed implant configurations.In chest wall reconstruction simulations,the maximum stresses observed in all prostheses did not exceed 38%of the implant material's yield stress in the most unfavorable case.Additionally,all the implants showed flexibility compatible with the physiological movements of the human thorax.
基金supported by the 2023 Youth Fund for Humanities and Social Sciences Research by the Ministry of Education of the People’s Republic of China(Grant No.23YJC740004).
文摘Based on BERTopic Model,the paper combines qualitative and quantitative methods to explore the reception of Can Xue’s translated works by analyzing readers’book reviews posted on Goodreads and Lovereading.We first collected book reviews from these two well-known websites by Python.Through topic analysis of these reviews,we identified recurring topics,including details of her translated works and appreciation of their translation quality.Then,employing sentiment and content analysis methods,the paper explored the emotional attitudes and the specific thoughts of readers toward Can Xue and her translated works.The fingdings revealed that,among the 408 reviews,though the reception of Can Xue’s translated works was relatively positive,the current level of attention and recognition remains insufficient.However,based on the research results,the paper can derive valuable insights into the translation and dissemination processes such as adjusting translation and dissemination strategies,so that the global reach of Chinese literature and culture can be better facilitated.
文摘Objective To examine the important roles of microRNAs （miRNAs） in regulating amphid structure and function, we performed a computational analysis for the genetic loci required for the sensory perception and their possibly corresponding miRNAs in C. elegans. Methods Total 55 genetic loci required for the amphid structure and function were selected. Sequence alignment was combined with E value evaluation to investigate and identify the possible corresponding miRNAs. Results Total 30 genes among the 55 genetic loci selected have their possible corresponding regulatory miRNA（s）, and identified genes participate in the regulation of almost all aspects of amphid structure and function. In addition, our data suggest that both the amphid structure and the amphid functions might be regulated by a series of network signaling pathways. Moreover, the distribution of miRNAs along the 3＇ untranslated region （UTR） of these 30 genes exhibits different patterns. Conclusion We present the possible miRNA-mediated signaling pathways involved in the regulation of chemosensation and thermosensation by controlling the corresponding sensory neuron and interneuron functions. Our work will be useful for better understanding of the miRNA-mediated control of the chemotaxis and thermotaxis in C. elegans.
文摘Objective To elucidate the important functions of microRNAs （miRNAs） in regulating synaptic assembly and function, we performed a computational analysis for the genetic loci required for the synaptic structure and function and their corresponding miRNAs in C. elegans. Methods Total 198 genetic loci required for the synaptic structure and function were selected. Sequence alignment was combined with E value evaluation to investigate and identify the possible corresponding miRNAs. Results Total 163 genes among the 198 genetic loci selected have their possibly corresponding regulatory miRNA （s）, which covered most of the important genetic loci required for the synaptic structure and function. Moreover, only 22 genes among the analyzed 38 genetic loci encoding synaptic proteins have more possibility to under the control of non-coding RNA genes. In addition, the distribution of miRNAs along the 3＇ untranslated region （UTR） of these 22 genes exhibits different patterns. Condusion Here we provide the computational screen and analysis results for the genetic loci required for synaptic structure and function and their possible corresponding miRNAs. These data will be useful for the further attempt to systematically determine the roles of miRNAs in synaptic assembly and function regulation in worms.
基金Project(2010CB732101) supported by the National Basic Research Program of China Project(51079145) supported by the National Natural Science Foundation of China
文摘An empirical expression of cohesion （C） and friction angle （Ф） for layered rock was suggested. This expression was compared with a test result made by the former researchers. The constitutive relationship of a transversely isotropic medium and Mohr-Coulomb criterion in which C and Ф vary with directions were employed, and a relative 3D elasto-plastic FEM code was developed, in which the important thing was to adopt a search-trial method to find the orientation angle （p） of shear failure plane （or weakest shear plane） with respect to the major principal stress as well as the corresponding C and Ф Taking an underground opening as the calculation object, the numerical analyses were carried out by using the FEM code for two cases of transversely isotropic rock and isotropic rock, respectively, and the computation results were compared. The results show that when the rock is a transversely isotropic one, the distributions of displacements, plastic zones and stress contours in the surrounding rock will be non-axisymmetric along the tunnel＇s vertical axis, which is very different from that of isotropic rock. The stability of the tunnel in transversely isotropic rock is relatively low.
基金CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico of Brazil) for the scholarship to Prof. Rodrigo Vidonscky Pinto.
文摘Application of nanofluids in heat pipes usually presents satisfactory experimental results regarding a thermal resistance reduction of the heat pipe.However,the existing computational studies connecting heat pipes and nanofluids lack a deeper discussion regarding the validity of the models currently used for representing the behaviour of a nanofluid in a heat pipe,particularly for unusual base fluids and nanoparticles such as carbon nanotubes or ethylene glycol.Thus,this comparative study presents the results of a set of computational simulations using pre-established equations for modelling a nanofluid in a heat pipe with experimental data from the literature.The results show agreement with the expected behaviour qualitatively and the presented maximum variations between 1.5% and 23.9% in comparison to the experimentally measured average temperatures.Also,the experimentally obtained temperature distribution of a heat pipe could not be reached numerically only with the use of adequate thermal properties,indicating that the boiling phenomenon is more complex than the current model used for computational simulations.Moreover,the existence of an optimal particle volume fraction for using nanofluids in this application could be observed by combining different properties models.
文摘In this paper, we investigate the properties of an alternative material for use in marine engineering, namely a rigid and light sandwich-structured composite made of expanded polystyrene and fiberglass. Not only does this material have an improved section modulus, but it is also inexpensive, light, easy to manipulate, and commercially available in various sizes. Using a computer program based on the finite element method, we calculated the hogging and sagging stresses and strains acting on a prismatic boat model composed of this material, and determined the minimum sizes and maximum permissible stresses to avoid deformation. Finally, we calculated the structural weight of the resulting vessel for comparison with another structure of comparable dimensions constructed from the commonly used core material Divinycell.
文摘Shrinkage cavity may be detrimental to mechanical performances of casting parts.As a consequence,design engineers often use overly large safety factors in many designs due to insufficient understanding of quantitative effects of shrinkage cavity defects.In this paper,process of Al alloy wheel impact test was computationally analyzed for both the wheel models with and without shrinkage cavity defects.Based on shrinkage cavity data obtained from industrial CT (Computerized Tomography),the shrinkage cavity defects were modeled with SSM (Shape Simplification Method),which reconstructs shrinkage cavity defects to hollow spheroid primitives.After the impact simulation was conducted,the results show that under impact test condition,the wheel considering shrinkage cavity defects may fracture while the sound-assumed wheel may not.
基金supported by the National Natural Science Foundation of China(11172020)the Fundamental Research Funds for the Central Universities+1 种基金the Aerospace Science and Technology Innovation Foundation of China Aerospace Science Corporationthe Innovation Fund of China Academy of Space Technology
文摘This paper deals with system engineering and design methodology for super low altitude satel ites in the view of the com-putational mission analysis. Due to the slight advance of imaging instruments, such as the focus of camera and the image element of charge coupled device （CCD）, it is an innovative and economical way to improve the camera’s resolution to enforce the satel ite to fly on the lower altitude orbit. DFH-3, the mature satel ite bus de-veloped by Chinese Academy of Space Technology, is employed to define the mass and power budgets for the computational mis-sion analysis and the detailed engineering design for super low altitude satel ites. An effective iterative algorithm is proposed to solve the ergodic representation of feasible mass and power bud-gets at the flight altitude under constraints. Besides, boundaries of mass or power exist for every altitude, where the upper boundary is derived from the maximum power, while the minimum thrust force holds the lower boundary before the power reaching the initial value. What’s more, an analytical algorithm is employed to numerical y investigate the coverage percentage over the altitude, so that the nominal altitude could be selected from al the feasi-ble altitudes based on both the mass and power budgets and the repetitive ground traces. The local time at the descending node is chosen for the nominal sun-synchronous orbit based on the average evaluation function. After determining the key orbital ele-ments based on the computational mission analysis, the detailed engineering design on the configuration and other subsystems, like power, telemetry telecontrol and communication （TT＆amp;C）, and attitude determination and control system （ADCS）, is performed based on the benchmark bus, besides, some improvements to the bus are also implemented to accommodate the flight at a super low altitude. Two operation strategies, drag-free closed-loop mode and on/off open-loop mode, are presented to maintain the satel-lite’s altitude. Final y, a flight planning schedule for the satel ite is demonstrated from its launch into the initial altitude at the very beginning to its decay to death in the end.
基金Aeronautical Science Foundation of China(2010ZA04001)National Natural Science Foundation of China (61073013,90818024)
文摘The fast-growing demand of computational fluid dynamics（CFD） application for computing resources stimulates the development of high performance computing（HPC） and meanwhile raises new requirements for the technology of parallel application performance monitor and analysis.In response to large-scale and long-time running for the application of CFD,online and scalable performance analysis technology is required to optimize the parallel programs as well as to improve their operational efficiency.As a result,this research implements a scalable infrastructure for online performance analysis on CFD application with homogeneous or heterogeneous system.The infrastructure is part of the parallel application performance monitor and analysis system（PAPMAS） and is composed of two modules which are scalable data transmission module and data storage module.The paper analyzes and elaborates this infrastructure in detail with respect to its design and implementation.Furthermore,some experiments are carried out to verify the rationality and high efficiency of this infrastructure that could be adopted to meet the practical needs.
文摘Elegans are one of the best model organisms in neural researches, and tropism movement is a typical learning and memorizing activity. Based on one imaging technique called Fast Track-Capturing Microscope (FTCM), we investigated the movement regulation. Two movement patterns are extracted from various trajectories through analysis on turning angle. Then we applied this classification on trajectory regulation on the compound gradient field, and theoretical results corresponded with experiments well, which can initially verify the conclusion. Our breakthrough is performed computational geometric analysis on trajectories. Several independent features were combined to describe movement properties by principal composition analysis (PCA) and support vector machine (SVM). After normalizing all data sets, no-supervising machine learning was processed along with some training under certain supervision. The final classification results performed perfectly, which indicates the further application of such computational analysis in biology researches combining with machine learning.
基金Supported by the National Natural Science Foundation of China(No.U1231108)
文摘A framework for accelerating modern long-running astrophysical simulations is presented, which is based on a hierarchical architecture where computational steering in the high-resolution run is performed under the guide of knowledge obtained in the gradually refined ensemble analyses. Several visualization schemes for facilitating ensemble management, error analysis, parameter grouping and tuning are also integrated owing to the pluggable modular design. The proposed approach is prototyped based on the Flash code, and it can be extended by introducing userdefined visualization for specific requirements. Two real-world simulations, i.e., stellar wind and supernova remnant, are carried out to verify the proposed approach.
基金Djordje Spasojevic and Svetislav Mijatovic acknowledge the support from the Ministry of Science,TechnologicalDevelopment and Innovation of the Republic of Serbia(Agreement No.451-03-65/2024-03/200162)S.J.ibid.(Agreement No.451-03-65/2024-03/200122)Bosiljka Tadic from the Slovenian Research Agency(program P1-0044).
文摘Disordered ferromagnets with a domain structure that exhibit a hysteresis loop when driven by the external magnetic field are essential materials for modern technological applications.Therefore,the understanding and potential for controlling the hysteresis phenomenon in thesematerials,especially concerning the disorder-induced critical behavior on the hysteresis loop,have attracted significant experimental,theoretical,and numerical research efforts.We review the challenges of the numerical modeling of physical phenomena behind the hysteresis loop critical behavior in disordered ferromagnetic systems related to the non-equilibriumstochastic dynamics of domain walls driven by external fields.Specifically,using the extended Random Field Ising Model,we present different simulation approaches and advanced numerical techniques that adequately describe the hysteresis loop shapes and the collective nature of the magnetization fluctuations associated with the criticality of the hysteresis loop for different sample shapes and varied parameters of disorder and rate of change of the external field,as well as the influence of thermal fluctuations and demagnetizing fields.The studied examples demonstrate how these numerical approaches reveal newphysical insights,providing quantitativemeasures of pertinent variables extracted from the systems’simulated or experimentally measured Barkhausen noise signals.The described computational techniques using inherent scale-invariance can be applied to the analysis of various complex systems,both quantum and classical,exhibiting non-equilibrium dynamical critical point or self-organized criticality.
基金supported by the National Natural Science Foundation of China (Nos. 61233005 and 61503013)the National Basic Research Program of China (No. 2014CB744202)+2 种基金Beijing Youth Talent ProgramFundamental Science on Novel Inertial Instrument & Navigation System Technology LaboratoryProgram for Changjiang Scholars and Innovative Research Team in University (IRT1203) for their valuable comments
文摘Inertial navigation system/visual navigation system(INS/VNS) integrated navigation is a commonly used autonomous navigation method for planetary rovers. Since visual measurements are related to the previous and current state vectors(position and attitude) of planetary rovers, the performance of the Kalman filter(KF) will be challenged by the time-correlation problem. A state augmentation method, which augments the previous state value to the state vector, is commonly used when dealing with this problem. However, the augmenting of state dimensions will result in an increase in computation load. In this paper, a state dimension reduced INS/VNS integrated navigation method based on coordinates of feature points is presented that utilizes the information obtained through INS/VNS integrated navigation at a previous moment to overcome the time relevance problem and reduce the dimensions of the state vector. Equations of extended Kalman filter(EKF) are used to demonstrate the equivalence of calculated results between the proposed method and traditional state augmented methods. Results of simulation and experimentation indicate that this method has less computational load but similar accuracy when compared with traditional methods.
基金Funded by the National 973 Program of China (No.2006CB701301)the Project of University Education and Research of HubeiProvince (No.20053039).
文摘The meaning to research the potential of VLBI for geodetic applications is summarized. And the observation models and their related parameters of geodetic interest are investigated. Then, the principle and method of using the random model in VLBI data processing are investigated. With the world wide VLBI data from 2000-2004, the conditions to compute the parameters of geodetic interest are introduced, and so are the computing methods and processes. And the computed resuits of the parameters of geodetic interest are analyzed.
文摘Adenylyl cyclases (ACs) are a special group of enzymes that catalyze formation of the second messenger molecule, 3',5'-cyclic adenosine monophosphate (cAMP) from 5'-adenosine triphosphate (ATP). Apparently, even though cAMP is increasingly becoming an important signaling molecule in higher plants, the identification of plant ACs has somewhat remained slow. Here we report the recombinant cloning, partial expression and affinity purification of the truncated version (AtAC<sup>261-388</sup>) of a putative Arabidopsis thaliana protein (AtAC: At3g21465) followed by a demonstration of its inherent enzymatic activity as an AC. Currently, AtAC is not assigned any particular function in A. thaliana but simply annotated as an AC-like protein and, therefore, we targeted it for our study to establish if it is indeed a bona fide AC molecule. From our work, we firstly, show through enzyme immunoassaying and mass spectrometry that the recombinant AtAC<sup>261-388</sup><sub> </sub>can generate cAMP from ATP in vitro in a manganese-dependent manner that is activated by calcium and hydrogen carbonate. Secondly, we reveal through computational analysis that the AC center of AtAC is solvent-exposed, and amenable to the unhindered access of ATP as a substrate for catalysis. Lastly, we show that the recombinant AtAC<sup>261-388</sup> can complement AC-deficiency (cyaA mutation) in SP850 cells when expressed in this mutant Escherichia coli strain.
基金supported by grants from the National Key Research and Development Program of China(No.2016YFC1101604)the Fundamental Research Funds for the Central Universities+2 种基金Clinical Medicine Plus X-Young Scholars Project of Peking University China(No.PKU2020LCXQ020)Guangdong Basic and Applied Basic Research Foundation(No.2019A1515110983,No.2021A1515012586)Bethune Charitable Foundation and CSPC Osteoporosis Research Foundation Project(No.G-X-2020-1107-21).
文摘Objective:Wallerian degeneration is a pathological process closely related to peripheral nerve regeneration following injury,and includes the disintegration and phagocytosis of peripheral nervous system cells.Traditionally,morphological changes are observed by performing immunofluorescence staining after sectioning,which results in the loss of some histological information.The purpose of this study was to explore a new,nondestmetive,and systematic method for observing axonal histological changes during Wallerian degeneration.Methods:Thirty male Thy1-YFP-16 mice(SPF grade,6 weeks old,20±5 g)were randomly selected and divided into clear,unobstructed brain imaging cocktails and computational analysis(CUBIC)optical clearing(n=15)and traditional method groups(n=15).Five mice in each group were sacrificed at 1st,3rd,and 5th day following a crush operation.The histological axon changes were observed by CUBIC light optical clearing treatment,direct tissue section imaging,and HE staining.Results:The results revealed that,compared with traditional imaging methods,there was no physical damage to the samples,which allowed for three-dimensional and deep-seated tissue imaging through CUBIC.Local image information could be nicely obtained by direct fluorescence imaging and HE staining,but it was difficult to obtain image information of the entire sample.At the same time,the image information obtained by fluorescence imaging and HE staining was partially lost.Conclusion:The combining of CUBIC and Thy1-YFP transgenic mice allowed for a clear and comprehensive observation of histological changes of axons in Wallerian degeneration.
基金Supported by the National Natural Science Foundation of China(No.20902001 and 21102001)the Natural Science Foundation of Anhui Province(No.090416220)the 211 Project of Anhui University
文摘The mixed-metal cluster Yb4O4（OiPr）16Na12 has been synthesized and structurally determined by IR, elemental analysis, and single-crystal X-ray diffraction. The crystal belongs to the cubic system, space group P23 with a = b = c = 13.9788（3）A, V = 2731.55（10）A3, Z = 1, Dc = 1.202 g/cm3, Mr = 1977.42,/J = 3.480 mm-1, F（000） = 972, the final R = 0.0288 and wR = 0.1511 for 1677 observed reflections with I 〉 2σ（I）. X-ray analysis reveals that Yb4O4（Oipr）16Na12 is centrosym- metric and the structure contains four ytterbium metals and twelve sodium metals, and each ytterbium atom is coordinated by six oxygen atoms. In addition, an ancillary computational analysis of the optimized molecular unit was provided. The large energy gap （3,31 eV） between HOMO and LUMO indicates that the structure framework is particularly stable.
