AIM: To study complement activation in 46 patients with alcoholic cirrhosis and ascites but no spontaneous bacterial peritonitis (SBP) and 10 healthy controls. METHODS: Complement activation was determined by the meas...AIM: To study complement activation in 46 patients with alcoholic cirrhosis and ascites but no spontaneous bacterial peritonitis (SBP) and 10 healthy controls. METHODS: Complement activation was determined by the measurement of soluble membrane attack complex (sMAC) concentrations in ascites and plasma. In patients, metabolic liver function was determined by the galactose elimination capacity and the clinical status assessed by the Model of End-Stage Liver Disease and Child-Pugh scores. RESULTS: Ascites sMAC levels were markedly higherthan in the corresponding plasma sample (median (range): 596 (170 - 1519) vs 160 (77 - 848) μg/L; P < 0.01). Ascites sMAC levels correlated positively with liver status. There was no relationship between ascites sMAC and leukocyte count. No relationship between ascites sMAC and blood C-reactive protein, albumin or neutrophile count was found. Plasma sMAC concentrations were slightly higher in patients than in controls [130 μg/L (70 - 204); P = 0.04]. Neither sMAC in ascites nor plasma was related to mortality. CONCLUSION: The increased sMAC concentration in ascites and plasma indicate an activation of the complement system in cirrhosis even in the absence of SBP. This was particularly evident in the peritoneal fluid and most marked in patients with preserved liver status. The high ascites sMAC levels may reflect transudation of membrane attack complexes from the liver. Whether this complement activation has any clinical implications remains to be clarified.展开更多
The nonlinear filter Boolean function of LILI-128 stream cipher generator is studied in this paper. First we measure the complexity of the stream ciphers sequence of LILI-128 stream cipher generator and obtain the sho...The nonlinear filter Boolean function of LILI-128 stream cipher generator is studied in this paper. First we measure the complexity of the stream ciphers sequence of LILI-128 stream cipher generator and obtain the shortest bit stream sequence reconstructed Boolean function of nonlinear filter in LILI-128 stream cipher generator. Then the least nonlinear Boolean function of generating stream cipher sequence is reconstructed by clusterig, nonlinear predictive and nonlinear synchronization from shortest bit stream sequence. We have verified the correctness of our reconstruction result by simulating the block diagram of Lili-128 keystream generator using our getting Boolean function and implement designers’ reference module of Lili-128 stream cipher public online, and two methods produce the same synchronous keystream sequence under same initial state, so that our research work proves that the nonlinear Boolean function of LILI-128 stream cipher generator is successfully broken.展开更多
基金Supported by grants from the Danish Medical Research Council
文摘AIM: To study complement activation in 46 patients with alcoholic cirrhosis and ascites but no spontaneous bacterial peritonitis (SBP) and 10 healthy controls. METHODS: Complement activation was determined by the measurement of soluble membrane attack complex (sMAC) concentrations in ascites and plasma. In patients, metabolic liver function was determined by the galactose elimination capacity and the clinical status assessed by the Model of End-Stage Liver Disease and Child-Pugh scores. RESULTS: Ascites sMAC levels were markedly higherthan in the corresponding plasma sample (median (range): 596 (170 - 1519) vs 160 (77 - 848) μg/L; P < 0.01). Ascites sMAC levels correlated positively with liver status. There was no relationship between ascites sMAC and leukocyte count. No relationship between ascites sMAC and blood C-reactive protein, albumin or neutrophile count was found. Plasma sMAC concentrations were slightly higher in patients than in controls [130 μg/L (70 - 204); P = 0.04]. Neither sMAC in ascites nor plasma was related to mortality. CONCLUSION: The increased sMAC concentration in ascites and plasma indicate an activation of the complement system in cirrhosis even in the absence of SBP. This was particularly evident in the peritoneal fluid and most marked in patients with preserved liver status. The high ascites sMAC levels may reflect transudation of membrane attack complexes from the liver. Whether this complement activation has any clinical implications remains to be clarified.
文摘The nonlinear filter Boolean function of LILI-128 stream cipher generator is studied in this paper. First we measure the complexity of the stream ciphers sequence of LILI-128 stream cipher generator and obtain the shortest bit stream sequence reconstructed Boolean function of nonlinear filter in LILI-128 stream cipher generator. Then the least nonlinear Boolean function of generating stream cipher sequence is reconstructed by clusterig, nonlinear predictive and nonlinear synchronization from shortest bit stream sequence. We have verified the correctness of our reconstruction result by simulating the block diagram of Lili-128 keystream generator using our getting Boolean function and implement designers’ reference module of Lili-128 stream cipher public online, and two methods produce the same synchronous keystream sequence under same initial state, so that our research work proves that the nonlinear Boolean function of LILI-128 stream cipher generator is successfully broken.
