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Multiscale structural complexity analysis of neuronal activity in suprachiasmatic nucleus:Insights from tetrodotoxin-induced disruptions
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作者 Ping Wang Changgui Gu Huijie Yang 《Chinese Physics B》 2025年第4期605-613,共9页
The suprachiasmatic nucleus in the hypothalamus is the master circadian clock in mammals,coordinating physiological processes with the 24-hour day–night cycle.Comprising various cell types,the suprachiasmatic nucleus... The suprachiasmatic nucleus in the hypothalamus is the master circadian clock in mammals,coordinating physiological processes with the 24-hour day–night cycle.Comprising various cell types,the suprachiasmatic nucleus(SCN)integrates environmental signals to maintain complex and robust circadian rhythms.Understanding the complexity and synchrony within SCN neurons is essential for effective circadian clock function.Synchrony involves coordinated neuronal firing for robust rhythms,while complexity reflects diverse activity patterns and interactions,indicating adaptability.Interestingly,the SCN retains circadian rhythms in vitro,demonstrating intrinsic rhythmicity.This study introduces the multiscale structural complexity method to analyze changes in SCN neuronal activity and complexity at macro and micro levels,based on Bagrov et al.’s approach.By examining structural complexity and local complexities across scales,we aim to understand how tetrodotoxin,a neurotoxin that inhibits action potentials,affects SCN neurons.Our method captures critical scales in neuronal interactions that traditional methods may overlook.Validation with the Goodwin model confirms the reliability of our observations.By integrating experimental data with theoretical models,this study provides new insights into the effects of tetrodotoxin(TTX)on neuronal complexities,contributing to the understanding of circadian rhythms. 展开更多
关键词 suprachiasmatic nucleus circadian rhythm complexITY synchrony multiscale structural complexity
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A fractal-based supremum and infimum complex belief entropy in complex evidence theory
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作者 Tianren LIU Zewei YU +2 位作者 Fuyuan XIAO Yangyang ZHAO Masayoshi ARITSUGI 《Chinese Journal of Aeronautics》 2025年第6期77-87,共11页
Complex evidence theory is a generalized Dempster-Shafer evidence theory,which has the ability to express uncertain information.One of the key issues is the uncertainty measure of Complex Basic Belief Assignment(CBBA)... Complex evidence theory is a generalized Dempster-Shafer evidence theory,which has the ability to express uncertain information.One of the key issues is the uncertainty measure of Complex Basic Belief Assignment(CBBA).However,the research on the uncertainty measure of complex evidence theory is still an open issue.Therefore,in this paper,first,the Fractal-based Complex Belief(FCB)entropy as a generalization of Fractal-based Belief(FB)entropy,which has superiority in uncertainty measurement of CBBA,is proposed.Second,on the basis of FCB entropy,we propose Fractal-based Supremum Complex Belief(FSCB)entropy and Fractal-based Infimum Complex Belief(FICB)entropy,with FSCB entropy as the upper bound and FICB entropy as the lower bound.They are collectively called the proposed FCB entropy.Furthermore,we analyze the properties,physical interpretation and numerical examples to prove the rationality of the proposed method.Finally,a practical information fusion application is proposed to prove that the proposed FCB entropy can reasonably measure the uncertainty of CBBA.The results show that,the proposed FCB entropy can handle the uncertainty measure of CBBA,which can be a reasonable way for uncertainty measure in complex evidence theory. 展开更多
关键词 complex evidence theory Uncertainty measure FRACTAL complex belief entropy Information fusion Classification
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Quantum Dynamics of Complex Systems
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作者 Xiang Sun 《Chinese Journal of Chemical Physics》 2025年第4期373-374,共2页
The ability to accurately simulate the time evolu-tion of quantum systems stands as a cornerstone of modern molecular science.It provides the essential mechanistic bridge between a system’s microscopic structure and ... The ability to accurately simulate the time evolu-tion of quantum systems stands as a cornerstone of modern molecular science.It provides the essential mechanistic bridge between a system’s microscopic structure and its macroscopic function,a challenge first envisioned by Feynman.The central difficulty,and the unifying theme of this Special Topic,is the problem of“complexity”:a multifaceted challenge arising from the interplay of strongly coupled electronic and vibrational degrees of freedom,quantum statistics,and the non-trivial,often non-Markovian,memory effects exerted by a surrounding environment. 展开更多
关键词 electronic vibrational degrees freedomquantum statistic quantum dynamics complex systems FEYNMAN electronic degrees freedom complexity molecular science mechanistic bridge
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Direct identification of energy transfer mechanism in Ce^(Ⅲ)-Mn^(Ⅱ)system by constructing molecular heteronuclear complexes
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作者 Huanyu Liu Gang Yu +6 位作者 Ruoyao Guo Hao Qi Jiayin Zheng Tong Jin Zifeng Zhao Zuqiang Bian Zhiwei Liu 《Chinese Chemical Letters》 2025年第2期156-160,共5页
Sensitization of metal-centered forbidden transitions is of great significance.Solid MnII-based phosphors with d-d forbidden transition sensitized by CeIIIwith d-f allowed transition are promising light conversion mat... Sensitization of metal-centered forbidden transitions is of great significance.Solid MnII-based phosphors with d-d forbidden transition sensitized by CeIIIwith d-f allowed transition are promising light conversion materials,but the energy transfer mechanism in CeIII-MnIIis still in dispute for the uncertainty of distances between metal centers.Herein,for the first time,we explored the energy transfer mechanism in two well-designed luminescent heteronuclear complexes with clear crystal structures,i.e.,Ce-N8-Mn and Ce-N2O6-Mn(N8=1,4,7,10,13,16,21,24-octaazabicyclo[8.8.8]hexacosane;N2O6=4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane).Short distances between metal centers facilitate efficient energy transfer from CeIIIto MnIIin both complexes,resulting in high photoluminescence quantum yield up to unity.After systematic study of the two heteronuclear complexes as well as two reference complexes Ce(N8)Br3and Ce(N2O6)Br3,we concluded that dipole-quadrupole interaction is the dominant energy transfer mechanism in the heteronuclear complexes. 展开更多
关键词 Dipole-quadrupole interaction Förster resonance energy transfer Manganese complex Cerium complex PHOTOLUMINESCENCE
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TIMM8A-TIMM13 Complex Exerts Oncogenic Functions in Lung Cancer
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作者 Shengmin Li Kejian Shi +1 位作者 Ying Wang Yi Zhang 《Oncology Research》 2025年第9期2435-2449,共15页
Objectives:Lung cancer represents a major global healthcare challenge,characterized by high annual incidence and mortality rates worldwide.Although targeted therapies for lung cancer have advanced,treatment outcomes f... Objectives:Lung cancer represents a major global healthcare challenge,characterized by high annual incidence and mortality rates worldwide.Although targeted therapies for lung cancer have advanced,treatment outcomes for advanced-stage patients remain suboptimal.This investigation examines the role of the translocase of the inner mitochondrial membrane(TIMM)8A-TIMM13 complex in lung cancer and evaluates its potential as a novel therapeutic target.Methods:A co-immunoprecipitation(Co-IP)assay was conducted to verify the interaction between TIMM8A and TIMM13.Differential gene expression analysis of TIMM8A or TIMM13 was executed using the TNMplot database,with survival estimates derived from the Kaplan-Meier plotter.Lung cancer cell proliferation was evaluated through Cell Counting Kit 8(CCK-8)and colony formation assays,while cell migration was assessed via Transwell assay.RNA sequencing identified the downstream effectors of TIMM13.RNAi technology facilitated the inhibition of TIMM8A or TIMM13 expression,which was measured through immunoblotting or qRT-PCR.Results:This investigation revealed that components of the TIMM8A-TIMM13 complex exhibited elevated expression in human lung cancer tissues,correlating with disease progression and poor overall survival rates among lung cancer patients.The suppression of either TIMM8A or TIMM13 inhibited cell proliferation and migration.Mechanistic studies through transcriptome analysis identified cell cycle-related pathways as potential key downstream effectors of the TIMM8A-TIMM13 complex.Subsequent experiments confirmed that the TIMM8A-TIMM13 complex significantly regulated the expression of cyclin D1(CCND1)and cyclin-dependent kinase 6(CDK6)complex.Conclusion:The elevated expression of TIMM8A-TIMM13 complex components plays a crucial role in lung cancer cell growth,suggesting its potential as a promising therapeutic target for lung cancer treatment. 展开更多
关键词 Lung cancer PROGNOSIS PROLIFERATION TIMM8A-TIMM13 complex CCND1-CDK6 complex
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Cartan-Eilenberg FP_(n)-Injective and FP_(n)-Flat Complexes
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作者 Zongyang XIE Bo LU 《Journal of Mathematical Research with Applications》 2025年第4期460-472,共13页
Let n≥1 be an integer.In this article,we study the notions of Cartan-Eilenberg FP_(n)injective and Cartan-Eilenberg FP_(n)-flat complexes.We also investigate duality pairs relative to the Cartan-Eilenberg FP_(n)-inje... Let n≥1 be an integer.In this article,we study the notions of Cartan-Eilenberg FP_(n)injective and Cartan-Eilenberg FP_(n)-flat complexes.We also investigate duality pairs relative to the Cartan-Eilenberg FP_(n)-injective and Cartan-Eilenberg FP_(n)-flat complexes.As applications,we obtain that any complex admits Cartan-Eilenberg FP_(n)-injective(resp.,Cartan-Eilenberg FP_(n)-flat)cover and preenvelope and we characterize left n-coherent rings using these two classes of complexes. 展开更多
关键词 Cartan-Eilenberg FP_(n)-injective complex Cartan-Eilenberg FP_(n)-flat complex duality pair cotorsion pair
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Management of perifoveal exudative vascular anomalous complex with laser treatment: a case report
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作者 Qing Chen Bin-Jian Wang +2 位作者 Yu-Zhu Gao Xue Wu Ming Zhang 《International Journal of Ophthalmology(English edition)》 2025年第5期965-968,共4页
Dear Editor,We describe a case diagnosed with exudative perifoveal vascular anomalous complex(ePVAC)successfully treated with focal laser photocoagulation(577 nm),achieving a favorable prognosis with best-corrected vi... Dear Editor,We describe a case diagnosed with exudative perifoveal vascular anomalous complex(ePVAC)successfully treated with focal laser photocoagulation(577 nm),achieving a favorable prognosis with best-corrected visual acuity(BCVA)of 20/20.Additionally,we discussed the identification of a possible early-onset non-ePVAC.The ePVAC is characterized as an isolated,aneurysmal abnormity near the macula and usually accompanied by cystic macular edema(ME)[1-2]. 展开更多
关键词 cystic macular edema me focal laser photocoagulation best corrected visual acuity laser treatment macular edema early onset non epvac exudative perifoveal vascular anomalous complex epvac successfully perifoveal exudative vascular anomalous complex
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Performance vs.Complexity Comparative Analysis of Multimodal Bilinear Pooling Fusion Approaches for Deep Learning-Based Visual Arabic-Question Answering Systems
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作者 Sarah M.Kamel Mai A.Fadel +1 位作者 Lamiaa Elrefaei Shimaa I.Hassan 《Computer Modeling in Engineering & Sciences》 2025年第4期373-411,共39页
Visual question answering(VQA)is a multimodal task,involving a deep understanding of the image scene and the question’s meaning and capturing the relevant correlations between both modalities to infer the appropriate... Visual question answering(VQA)is a multimodal task,involving a deep understanding of the image scene and the question’s meaning and capturing the relevant correlations between both modalities to infer the appropriate answer.In this paper,we propose a VQA system intended to answer yes/no questions about real-world images,in Arabic.To support a robust VQA system,we work in two directions:(1)Using deep neural networks to semantically represent the given image and question in a fine-grainedmanner,namely ResNet-152 and Gated Recurrent Units(GRU).(2)Studying the role of the utilizedmultimodal bilinear pooling fusion technique in the trade-o.between the model complexity and the overall model performance.Some fusion techniques could significantly increase the model complexity,which seriously limits their applicability for VQA models.So far,there is no evidence of how efficient these multimodal bilinear pooling fusion techniques are for VQA systems dedicated to yes/no questions.Hence,a comparative analysis is conducted between eight bilinear pooling fusion techniques,in terms of their ability to reduce themodel complexity and improve themodel performance in this case of VQA systems.Experiments indicate that these multimodal bilinear pooling fusion techniques have improved the VQA model’s performance,until reaching the best performance of 89.25%.Further,experiments have proven that the number of answers in the developed VQA system is a critical factor that a.ects the effectiveness of these multimodal bilinear pooling techniques in achieving their main objective of reducing the model complexity.The Multimodal Local Perception Bilinear Pooling(MLPB)technique has shown the best balance between the model complexity and its performance,for VQA systems designed to answer yes/no questions. 展开更多
关键词 Arabic-VQA deep learning-based VQA deep multimodal information fusion multimodal representation learning VQA of yes/no questions VQA model complexity VQA model performance performance-complexity trade-off
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Copper complexes of anthrahydrazone bearing pyridyl side chain:Synthesis,crystal structure,anticancer activity,and DNA binding 被引量:1
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作者 HUANG Yao WU Yingshu +5 位作者 BAO Zhichun HUANG Yue TANG Shangfeng LIU Ruixue LIU Yancheng LIANG Hong 《无机化学学报》 北大核心 2025年第1期213-224,共12页
To expand the study on the structures and biological activities of the anthracyclines anticancer drugs and reduce their toxic side effects,the new anthraquinone derivatives,9‑pyridylanthrahydrazone(9‑PAH)and 9,10‑bisp... To expand the study on the structures and biological activities of the anthracyclines anticancer drugs and reduce their toxic side effects,the new anthraquinone derivatives,9‑pyridylanthrahydrazone(9‑PAH)and 9,10‑bispyridylanthrahydrazone(9,10‑PAH)were designed and synthesized.Utilizing 9‑PAH and 9,10‑PAH as promising anticancer ligands,their respective copper complexes,namely[Cu(L1)Cl_(2)]Cl(1)and{[Cu_(4)(μ_(2)‑Cl)_(3)Cl_(4)(9,10‑PAH)_(2)(DMSO)_(2)]Cl_(2)}_(n)(2),were subsequently synthesized,where the new ligand L1 is formed by coupling two 9‑PAH ligands in the coordination reaction.The chemical and crystal structures of 1 and 2 were elucidated by IR,MS,elemental analysis,and single‑crystal X‑ray diffraction.Complex 1 forms a mononuclear structure.L1 coordinates with Cu through its three N atoms,together with two Cl atoms,to form a five‑coordinated square pyramidal geometry.Complex 2 constitutes a polymeric structure,wherein each structural unit centrosymmetrically encompasses two five‑coordinated binuclear copper complexes(Cu1,Cu2)of 9,10‑PAH,with similar square pyramidal geometry.A chlorine atom(Cl_(2)),located at the symmetry center,bridges Cu1 and Cu1A to connect the two binuclear copper structures.Meanwhile,the two five‑coordinated Cu2 atoms symmetrically bridge the adjacent structural units via one coordinated Cl atom,respectively,thus forming a 1D chain‑like polymeric structure.In vitro anticancer activity assessments revealed that 1 and 2 showed significant cytotoxicity even higher than cisplatin.Specifically,the IC_(50)values of 2 against HeLa‑229 and SK‑OV‑3 cancer cell lines were determined to be(5.92±0.32)μmol·L^(-1)and(6.48±0.39)μmol·L^(-1),respectively.2 could also block the proliferation of HeLa‑229 cells in S phase and significantly induce cell apoptosis.In addition,fluorescence quenching competition experiments suggested that 2 might interact with DNA by an intercalative binding mode,offering insights into its underlying anticancer mechanism.CCDC:2388918,1;2388919,2. 展开更多
关键词 anthrahydrazone metal complex crystal structure anticancer activity cell apoptosis
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基于JWST中红外观测数据的X-Complex小行星物理性质反演研究
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作者 矫恒越 徐小萌 +4 位作者 徐天弈 吴昀昭 金岩 张海波 刘志军 《空间控制技术与应用》 北大核心 2025年第5期16-25,共10页
X-complex小行星是一类在可见光-近红外波段无诊断性光谱特征、成分类型多样的重要天体,其中部分可能是已分异天体金属核心残余,是太阳系早期热演化研究及太空采矿的重要目标对象.由于Xcomplex小行星在可见光-近红外波段范围缺乏光谱吸... X-complex小行星是一类在可见光-近红外波段无诊断性光谱特征、成分类型多样的重要天体,其中部分可能是已分异天体金属核心残余,是太阳系早期热演化研究及太空采矿的重要目标对象.由于Xcomplex小行星在可见光-近红外波段范围缺乏光谱吸.收特征,热红外高光谱是研究X-complex小行星的重要手段.基于韦布空间望远镜中红外观测数据对7颗物理性质尚不明确的X-complex小行星进行了研究,利用近地小行星热模型及马尔科夫链蒙特卡洛方法反演了它们的发射率、直径、热集束参数以及几何反照率等物理信息.相较于以往观测,本文充分利用韦布空间望远镜的红外高光谱优势,通过连续谱段数据约束模型,提高了反演结果的可靠性.结果显示,这7颗小行星的直径范围为17.30~22.55 km,比喷气推进实验室数据库结果平均偏小41.5%,表明以往对小尺寸X-complex小行星直径存在普遍高估,进而反映其实际表面几何反照率普遍高于既有认知.反演的红外发射率光谱显示它们比硅酸盐小行星发射率低0.064~0.093,暗示它们表面可能被低发射率物质覆盖.所有小行星的中红外发射率光谱均展示了光谱特征,进一步印证了反演结果的可靠性. 展开更多
关键词 小行星 JWST 热物理模型 X-complex小行星 红外高光谱
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Zircon U-Pb-Hf and Trace Element Signatures Reveal the Petrogenesis of the Jiuyishan Granitic Complex,South China:Implications for W-Sn and Rare Metal Mineralization 被引量:1
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作者 Wenzhou Xiao Chaoyun Liu +6 位作者 Kaixuan Tan Xianzhe Duan Qinglin Sui Kaituo Shi Peng Feng Mabrouk Sami Quan Ou 《Journal of Earth Science》 2025年第3期1069-1089,共21页
The Jiuyishan granitic complex,located in the Nanling Range,South China,is composed of five granitic plutons(Xuehuading,Jinjiling,Pangxiemu,Shaziling and Xishan).Zircon U-Pb dating of four plutons(Jinjiling,Pangxiemu,... The Jiuyishan granitic complex,located in the Nanling Range,South China,is composed of five granitic plutons(Xuehuading,Jinjiling,Pangxiemu,Shaziling and Xishan).Zircon U-Pb dating of four plutons(Jinjiling,Pangxiemu,Shaziling and Xishan)yielded similar ages of approximately 153 Ma,indicating indistinguishable ages within error.Three plutons except the Shaziling pluton,have consistentε_(Nd)(t)(-7.8 to-5.8)andε_(Hf)(t)(-9.1 to-2.2)values,which are similar to those of the lower crustal granulitic metasedimentary and meta-igneous rocks in South China.Compared to other three plutons,the Shaziling pluton has consistentε_(Nd)(t)(-7.4 to-6.8)andε_(Hf)(t)(-7.5 to-4.7)values and shows similar source,but the Shaziling mafic microgranular enclaves(MMEs)show variableε_(Hf)(t)(-14.2 to 4.8)values,indicating a remarkable mantle magma injection of the Shaziling pluton.Zircon Ce/Sm-Yb/Gd,whole-rock CaO-P_(2)O_(5)and CaO-TiO_(2)linear trends reveal that from the Xishan to the Shaziling and from the Jinjiling to the Pangxiemu granites,they experienced apatite and titanite fractionation,respectively.Zircon Th,U,Nb,Ta,Hf,Ti,Y,P and rare earth element(REE)contents and whole-rock Sr,Ba and Rb contents also show that the Shaziling,Xishan,Jinjiling and Pangxiemu granites followed a discontinuous evolutionary series,but the Pangxiemu granites exhibit highly evolved nature.Four main controlling factors of W-Sn and rare metal mineralization in granitic rocks were discussed,and we found that the mineralization in Jiuyishan granitic complex was mainly controlled by the fractionation degree and crystallization temperature,but were rarely affected by oxygen fugacity and mantle material input.The Pangxiemu granites show particularly higher Rb and Ta contents than the other three plutons,implying that the ore deposits developed in the Jiuyishan Complex were directly related to the most evolved Pangxiemu pluton,with the occurrence of Rb and Ta as the most likely rare metal mineralization in the Jiuyishan District.A crystal mush model is proposed to interpret the petrogenetic and mineralizing processes of the Jiuyishan granitic complex. 展开更多
关键词 Jiuyishan granitic complex ZIRCON fractionation geochemistry rare metal mineralization
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Data-Driven Prediction in Complex Systems of Virus Evolution and Global Warming 被引量:1
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作者 LUO Liaofu LÜJun 《内蒙古大学学报(自然科学版)》 2025年第1期1-7,共7页
A complex system is inherently high-dimensional.Recent studies indicate that,even without complete knowledge of its evolutionary dynamics,the future behavior of such a system can be predicted using time-series data(da... A complex system is inherently high-dimensional.Recent studies indicate that,even without complete knowledge of its evolutionary dynamics,the future behavior of such a system can be predicted using time-series data(data-driven prediction).This suggests that the essential dynamics of a complex system can be captured through a low-dimensional representation.Virus evolution and climate change are two examples of complex,time-varying systems.In this article,we show that mutations in the spike protein provide valuable data for predicting SARS-CoV-2 variants,forecasting the possible emergence of the new macro-lineage Q in the near future.Our analysis also demonstrates that carbon dioxide concentration is a reliable indicator for predicting the evolution of the climate system,extending global surface air temperature(GSAT)forecasts through 2500. 展开更多
关键词 data-drivenprediction complex system virus evolution global warming
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Exploring the Effects of Background Image Complexity and Map Symbol Load on the Usability of Image-maps 被引量:1
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作者 PENG Qian XIA Yuxin QIU Zeren 《Journal of Geodesy and Geoinformation Science》 2025年第2期5-20,共16页
Image-maps,a hybrid design with satellite images as background and map symbols uploaded,aim to combine the advantages of maps’high interpretation efficiency and satellite images’realism.The usability of image-maps i... Image-maps,a hybrid design with satellite images as background and map symbols uploaded,aim to combine the advantages of maps’high interpretation efficiency and satellite images’realism.The usability of image-maps is influenced by the representations of background images and map symbols.Many researchers explored the optimizations for background images and symbolization techniques for symbols to reduce the complexity of image-maps and improve the usability.However,little literature was found for the optimum amount of symbol loading.This study focuses on the effects of background image complexity and map symbol load on the usability(i.e.,effectiveness and efficiency)of image-maps.Experiments were conducted by user studies via eye-tracking equipment and an online questionnaire survey.Experimental data sets included image-maps with ten levels of map symbol load in ten areas.Forty volunteers took part in the target searching experiments.It has been found that the usability,i.e.,average time viewed(efficiency)and average revisits(effectiveness)of targets recorded,is influenced by the complexity of background images,a peak exists for optimum symbol load for an image-map.The optimum levels for symbol load for different image-maps also have a peak when the complexity of the background image/image map increases.The complexity of background images serves as a guideline for optimum map symbol load in image-map design.This study enhanced user experience by optimizing visual clarity and managing cognitive load.Understanding how these factors interact can help create adaptive maps that maintain clarity and usability,guiding AI algorithms to adjust symbol density based on user context.This research establishes the practices for map design,making cartographic tools more innovative and more user-centric. 展开更多
关键词 remote sensing image map point label complexity
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A phenylphenthiazide anchored Tb(Ⅲ)-cyclen complex for fluorescent turn-on sensing of ClO^(-) 被引量:1
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作者 Ya-Ping Liu Zhi-Rong Gui +4 位作者 Zhen-Wen Zhang Sai-Kang Wang Wei Lang Yanzhu Liu Qian-Yong Cao 《Chinese Chemical Letters》 2025年第2期269-273,共5页
A phenylphenothiazine anchored Tb(Ⅲ)-cyclen complex PTP-Cy-Tb for hypochlorite ion(ClO^(-))detection has been designed and prepared.PTP-Cy-Tb shows a weak Tb-based emission with AIE-characteristics in aqueous solutio... A phenylphenothiazine anchored Tb(Ⅲ)-cyclen complex PTP-Cy-Tb for hypochlorite ion(ClO^(-))detection has been designed and prepared.PTP-Cy-Tb shows a weak Tb-based emission with AIE-characteristics in aqueous solutions.After addition of ClO^(-),the fluorescence of PTP-Cy-Tb gives a large enhancement for oxidization the thioether to sulfoxide group.The detection limit of PTP-Cy-Tb toward ClO^(-)is as low as 8.85 nmol/L.The sensing mechanism was detailedly investigated by time of flight mass spectrometer(TOF-MS),Fourier transform infrared spectroscopy(FT-IR)and density functional theory(DFT)calculation.In addition,PTP-Cy-Tb has been successfully used for on-site and real-time detection of ClO^(-)in real water samples by using the smartphone-based visualization method and test strips. 展开更多
关键词 Phenylphenothiazine Tb(III)complex AIE Hypochlorite ion SENSING
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A mitochondria targeting Ir(Ⅲ)complex triggers ferroptosis and autophagy for cancer therapy:A case of aggregation enhanced PDT strategy for metal complexes 被引量:1
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作者 Panpan Wang Hongbao Fang +5 位作者 Mengmeng Wang Guandong Zhang Na Xu Yan Su Hongke Liu Zhi Su 《Chinese Chemical Letters》 2025年第1期374-380,共7页
Metal complexes hold significant promise in tumor diagnosis and treatment.However,their potential applications in photodynamic therapy(PDT)are hindered by issues such as poor photostability,low yield of reactive oxyge... Metal complexes hold significant promise in tumor diagnosis and treatment.However,their potential applications in photodynamic therapy(PDT)are hindered by issues such as poor photostability,low yield of reactive oxygen species(ROS),and aggregation-induced ROS quenching.To address these challenges,we present a molecular self-assembly strategy utilizing aggregation-induced emission(AIE)conjugates for metal complexes.As a proof of concept,we synthesized a mitochondrial-targeting cyclometalated Ir(Ⅲ)photosensitizer Ir-TPE.This approach significantly enhances the photodynamic effect while mitigating the dark toxicity associated with AIE groups.Ir-TPE readily self-assembles into nanoaggregates in aqueous solution,leading to a significant production of ROS upon light irradiation.Photoirradiated Ir-TPE triggers multiple modes of death by excessively accumulating ROS in the mitochondria,resulting in mitochondrial DNA damage.This damage can lead to ferroptosis and autophagy,two forms of cell death that are highly cytotoxic to cancer cells.The aggregation-enhanced photodynamic effect of Ir-TPE significantly enhances the production of ROS,leading to a more pronounced cytotoxic effect.In vitro and in vivo experiments demonstrate this aggregation-enhanced PDT approach achieves effective in situ tumor eradication.This study not only addresses the limitations of metal complexes in terms of low ROS production due to aggregation but also highlights the potential of this strategy for enhancing ROS production in PDT. 展开更多
关键词 Metal complex AIEgens Mitochondria targeting Enhanced photodynamic therapy Anticancer agent
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Diversity,Complexity,and Challenges of Viral Infectious Disease Data in the Big Data Era:A Comprehensive Review 被引量:1
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作者 Yun Ma Lu-Yao Qin +1 位作者 Xiao Ding Ai-Ping Wu 《Chinese Medical Sciences Journal》 2025年第1期29-44,I0005,共17页
Viral infectious diseases,characterized by their intricate nature and wide-ranging diversity,pose substantial challenges in the domain of data management.The vast volume of data generated by these diseases,spanning fr... Viral infectious diseases,characterized by their intricate nature and wide-ranging diversity,pose substantial challenges in the domain of data management.The vast volume of data generated by these diseases,spanning from the molecular mechanisms within cells to large-scale epidemiological patterns,has surpassed the capabilities of traditional analytical methods.In the era of artificial intelligence(AI)and big data,there is an urgent necessity for the optimization of these analytical methods to more effectively handle and utilize the information.Despite the rapid accumulation of data associated with viral infections,the lack of a comprehensive framework for integrating,selecting,and analyzing these datasets has left numerous researchers uncertain about which data to select,how to access it,and how to utilize it most effectively in their research.This review endeavors to fill these gaps by exploring the multifaceted nature of viral infectious diseases and summarizing relevant data across multiple levels,from the molecular details of pathogens to broad epidemiological trends.The scope extends from the micro-scale to the macro-scale,encompassing pathogens,hosts,and vectors.In addition to data summarization,this review thoroughly investigates various dataset sources.It also traces the historical evolution of data collection in the field of viral infectious diseases,highlighting the progress achieved over time.Simultaneously,it evaluates the current limitations that impede data utilization.Furthermore,we propose strategies to surmount these challenges,focusing on the development and application of advanced computational techniques,AI-driven models,and enhanced data integration practices.By providing a comprehensive synthesis of existing knowledge,this review is designed to guide future research and contribute to more informed approaches in the surveillance,prevention,and control of viral infectious diseases,particularly within the context of the expanding big-data landscape. 展开更多
关键词 viral infectious diseases big data data diversity and complexity data standardization artificial intelligence data analysis
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Chromosomal passenger complex-cyclin/CDK axis correlated with poor lung cancer prognosis 被引量:1
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作者 Prerna Vats Sakshi Nirmal +1 位作者 Ashok Kumar Rajeev Nema 《Journal of Biomedical Research》 2025年第5期530-533,I0039-I0045,共11页
Dear Editor,Lung cancer is a major global health concern,with 2.2 million patients diagnosed in 2020.Non-small cell lung cancer(NSCLC)accounts for 80%of these cases,primarily comprising two subtypes:lung adenocarcinom... Dear Editor,Lung cancer is a major global health concern,with 2.2 million patients diagnosed in 2020.Non-small cell lung cancer(NSCLC)accounts for 80%of these cases,primarily comprising two subtypes:lung adenocarcinoma(LUAD)and squamous cell carcinoma(LUSC)[1].Researchers use immunohisto-chemistry,next-generation sequencing,and single-cell RNA sequencing to study genetic alterations,tumor heterogeneity,and tumor microenvironments,aiming to identify potential therapeutic options for specific NSCLC subtypes[2]. 展开更多
关键词 non small cell lung cancer lung adenocarcinoma poor prognosis squamous cell carcinoma lusc researchers chromosomal passenger complex cyclin cdk axis lung cancer squamous cell carcinoma
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Synthesis and fluorescent properties of a one-dimensional Tb-calixarene complex as a luminescent thermometer material
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作者 PENG Dan WANG Hao +2 位作者 WANG Yanyan YOU Hongpeng LIAO Wuping 《无机化学学报》 北大核心 2025年第9期1859-1866,共8页
Luminescence thermometry has attracted more and more attention due to its non-contact and noninvasive operation,fast response,high spatial resolution,and so on,for which the luminescent thermometers are the key.Here,a... Luminescence thermometry has attracted more and more attention due to its non-contact and noninvasive operation,fast response,high spatial resolution,and so on,for which the luminescent thermometers are the key.Here,a 1D complex[Tb_(4)(HTC4A)(TC4A)(OBBA)_(2)(CH_(3)OH)_(4)(μ4-OH)]n(1)was obtained by solvothermal synthesis,where H 4TC4A=p-tert-butylthiacalix[4]arene,and H_(2)OBBA=4,4'-oxybisbenzoic acid.This complex is featured with a chain-like polymer constructed by bridging some sandwich-like Tb_(4)-(TC4A)_(2)entities through OBBA2-ligands.It exhibited the characteristic emission of the Tb^(3+)ion.Both fluorescence intensity and lifetime decreased with increasing temperature.The relative sensitivity was up to 8.743%·K^(-1)at 473 K,indicating it is a good ratiometric luminescent thermometer.This complex had good stability under different pH values and in common solvents.CCDC:2392643. 展开更多
关键词 TERBIUM CALIXARENES complexes luminescent thermometer
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Synthesis,crystal structure,thermal decomposition mechanism,and fluorescence properties of benzoic acid and 4-hydroxy-2,2′:6′,2″-terpyridine lanthanide complexes
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作者 HAN Yahui ZHAO Jinjin +1 位作者 REN Ning ZHANG Jianjun 《无机化学学报》 北大核心 2025年第5期969-982,共14页
Two novel lanthanide complexes,[Sm_(2)(BA)_(6)(4-OH-terpy)_(2)]·2H_(2)O·2EtOH(1)and[Pr_(2)(BA)_(6)(4-OH-terpy)_(2)(H_(2)O)_(2)]·HBA·H_(2)O(2),where HBA=benzoic acid,4-OH-terpy=4-hydroxy-2,2'∶6... Two novel lanthanide complexes,[Sm_(2)(BA)_(6)(4-OH-terpy)_(2)]·2H_(2)O·2EtOH(1)and[Pr_(2)(BA)_(6)(4-OH-terpy)_(2)(H_(2)O)_(2)]·HBA·H_(2)O(2),where HBA=benzoic acid,4-OH-terpy=4-hydroxy-2,2'∶6',2″-terpyridine,were successfully synthesized using ultrasonic dissolution and the conventional solution method with two mixed ligands HBA and 4-OH-terpy.During the synthesis,4-OH-terpy was involved in the reaction as a neutral ligand,while HBA,in its deprotonated form(BA-),coordinated with the lanthanide ions as an acidic ligand.The crystal structures of these two complexes were precisely determined by single-crystal X-ray diffraction.Elemental analysis,infrared and Raman spectroscopy,and powder X-ray diffraction techniques were also employed to further explore the physicochemical properties of the two complexes.The single-crystal X-ray diffraction data indicate that,despite their structural differences,both complexes belong to the triclinic crystal system P1 space group.The central lanthanide ions have the same coordination number but exhibit different coordination environments.To comprehensively evaluate the thermal stability of these two complexes,comprehensive tests including thermogravimetric analysis,differential thermogravimetric analysis,differential scanning calorimetry,Fourier transform infrared spectroscopy,and mass spectrometry were conducted.Meanwhile,an in-depth investigation was conducted into the 3D infrared stacked images and mass spectra of the gases emitted from the complexes.In addition,studies of the fluorescence properties of complex1 showed that it exhibited fluorescence emission matching the Sm^(3+)characteristic transition. 展开更多
关键词 lanthanide complexes crystal structure THERMOCHEMISTRY fluorescence spectrum
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Parametric Dependence of Modified Yukawa Potential and Consequent Structure Changes of 2D Magnetized Complex Plasma
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作者 Li Xingyang Li Fei +2 位作者 Ma Jinghan Li Xinru Kong Wei 《南开大学学报(自然科学版)》 北大核心 2025年第2期78-86,共9页
For the magnetized complex plasma,dependences of modified Yukawa potential on the gov-erning parameters,viz.,mass ratio md/mi,number ratio nd/ne0,charge magnitude Q/e,and temperature ratio Te/Ti are investigated.It is... For the magnetized complex plasma,dependences of modified Yukawa potential on the gov-erning parameters,viz.,mass ratio md/mi,number ratio nd/ne0,charge magnitude Q/e,and temperature ratio Te/Ti are investigated.It is found that md/mi,nd/ne0 and Q/e contribute to the coupling strength of the system,and Te/Ti contributes to the shielding cloud surrounding the charged dust particles.Further analysis shows that the modified Yukawa potential depends on Te/Ti.The consequent structure changes of the system are discussed based on the Langevin dynamics simulation.It is found that the variation of Ham-iltonian contributes to the equilibrium structure of the system. 展开更多
关键词 complex plasma magnetic field modified Yukawa potential STRUCTURE
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