THE theory of nilpotent Lie algebra is very important in the theory of finite-dimensional Lie al-gebras. Because of its extraordinary complexity, one usually studies various classes of specialnilpotent Lie algebras. I...THE theory of nilpotent Lie algebra is very important in the theory of finite-dimensional Lie al-gebras. Because of its extraordinary complexity, one usually studies various classes of specialnilpotent Lie algebras. In the study of complete Lie algebras, a class of special nilpotent Lie al-gebras (called completable nilpotent Lie algebras) was discovered. In this letter, we will展开更多
Let T_(n) and S_(n) be the full transformation semigroup and the symmetric group on X_(n)={1,2,...,n},respectively.Let G be a transitiveimprimitive subgroupof S_(n) with nontrivial blocksΔand letαbe a transformation...Let T_(n) and S_(n) be the full transformation semigroup and the symmetric group on X_(n)={1,2,...,n},respectively.Let G be a transitiveimprimitive subgroupof S_(n) with nontrivial blocksΔand letαbe a transformation in T_(n)\S_(n).The kernel ofαis the partition of X_(n) induced by the equivalence relation{(x,y)|xα=yα};the kernel type ofαis the partition of n given by the sizes of the parts of the kernel.A transformation semigroup is called synchronizing if it contains a constant map.Then a group G synchronizes a transformationαif the semigroup(G,α)contains a constant map.In this paper,we study a transitive imprimitive permutation group G together with a non-invertible transformationαthat generate a synchronizing semigroup.We mainly discuss 7 cases where G synchronizes a special transformationαwith each kernel class A_(i)(A_(1)j)satisfying|A_(i)∩Δ|=1(|A_(1)j∩Δ|=1)for all blocksΔofG,that is,the kernel type ofαis(|A_(1)|,1,...,1),(|A_(1)1|,...,|A_(1m)|,|A_(2)|,...,|Ar|),or(|A_(1)|,...,|A_(t)|,1,...,1),or the rank is 2,3,4,or n-2.展开更多
In this paper,we give the double inequalities of a special quasi-arithmetic mean E(a,b)and the Seifert-like elliptic integral mean V(a,b)under the combination of generalized Heronian mean Hw(a,b),harmonic mean H(a,b)a...In this paper,we give the double inequalities of a special quasi-arithmetic mean E(a,b)and the Seifert-like elliptic integral mean V(a,b)under the combination of generalized Heronian mean Hw(a,b),harmonic mean H(a,b)and arithmetic mean A(a,b).As applications,we obtain two new optimal bounds for the second kind of complete elliptic integral".Finally,numerical experiments are performed to compare these with some known bounds of",and the improved effect is verified.展开更多
We discuss a class of filiform Lie superalgebras Ln,m. From these Lie superalgebras, all the other filiform Lie superalgebras can be obtained by deformations. We have decompositions of Der0（Ln,m） and Dery（Ln,m）. B...We discuss a class of filiform Lie superalgebras Ln,m. From these Lie superalgebras, all the other filiform Lie superalgebras can be obtained by deformations. We have decompositions of Der0（Ln,m） and Dery（Ln,m）. By computing a maximal torus on each Ln,m, we show that Ln,m are completable nilpotent Lie superalgebras. We also view Ln,m as Lie algebras, prove that Ln,m are of maximal rank, and show that Ln,m are completable nilpotent Lie algebras. As an application of the results, we show a Heisenberg superalgebra is a completable nilpotent Lie superalgebra.展开更多
International Journal of Minerals,Metallurgy and Materials is dedicated to the publication and the dissemination of original research articles (and occasional invited reviews) in the fields of Minerals,Metallurgy and ...International Journal of Minerals,Metallurgy and Materials is dedicated to the publication and the dissemination of original research articles (and occasional invited reviews) in the fields of Minerals,Metallurgy and Materials.It is covered by EI Compendex,SCI Expanded,Chemical Abstract,etc.Manuscript preparation The following components are required for a complete manuscript:Title,Author(s),Author affiliation(s),Abstract,Keywords,Main text,Acknowledgements and References.展开更多
BACKGROUND Sorafenib has been the conventional treatment for advanced hepatocellular carcinoma(HCC)since 2008.While radiological complete responses are extremely rare,improved supportive care and multidisciplinary app...BACKGROUND Sorafenib has been the conventional treatment for advanced hepatocellular carcinoma(HCC)since 2008.While radiological complete responses are extremely rare,improved supportive care and multidisciplinary approaches in clinical practice may explain the recent increase in case reports and retrospective series documenting such responses.CASE SUMMARY This case series describes 3 patients with advanced HCC who achieved durable complete responses using first-line sorafenib therapy,even in the presence of portal vein thrombosis or extrahepatic spread,and highlights the potential for sustained remission in selected patients.Dermatologic toxicity and non-viral etiology may correlate with favorable outcomes;however,reliable predictive biomarkers for sorafenib response are lacking.CONCLUSION Future research into the etiology and molecular differences in HCC is necessary to develop more personalized therapy options.展开更多
Breast cancer exhibits profound biological and spatial heterogeneity,which contributes to variable responses to neoadjuvant chemotherapy(NAC)and challenges precision treatment planning.Radiomics,an emerging discipline...Breast cancer exhibits profound biological and spatial heterogeneity,which contributes to variable responses to neoadjuvant chemotherapy(NAC)and challenges precision treatment planning.Radiomics,an emerging discipline that converts standard medical images into high-dimensional quantitative data,offers a non-invasive and reproducible means to capture tumor phenotype,heterogeneity,and treatment-induced changes.This review provides a comprehensive overview of recent advances in radiomics for breast cancer NAC,emphasizing the roles in predicting a pathologic complete response(pCR),monitoring early therapeutic efficacy,and quantifying intratumoral heterogeneity.Among imaging modalities,magnetic resonance imaging(MRI)-based radiomics,particularly utilizing dynamic contrast-enhanced and diffusion-weighted sequences,demonstrates robust predictive performance for the pCR,with multi-center studies reporting area under the curve(AUC)values>0.80.Longitudinal and delta-radiomics approaches further enhance early response evaluation by tracking temporal alterations in imaging features that precede measurable morphologic regression.Radiomic assessment of tumor heterogeneity,especially in triple-negative breast cancer(TNBC),reveals strong associations with immune infiltration,metabolic reprogramming,and therapeutic resistance,providing mechanistic insight into radiomic biomarkers.Integrative multi-omics frameworks,combining radiomics with genomics,transcriptomics and pathomics,are increasingly elucidating the biological underpinnings of imaging phenotypes,improving both model interpretability and clinical relevance.Despite these advances,widespread clinical adoption of radiomics is limited by methodologic variability,lack of standardization,and insufficient external validation.Future efforts should focus on harmonized imaging protocols,explainable artificial intelligence,and prospective multi-center trials to translate radiomics into a clinically actionable tool.Collectively,radiomics represents a transformative approach for individualized response prediction and dynamic treatment optimization in precision breast cancer management(Figure 1).展开更多
UAV-mounted intelligent reflecting surface(IRS)helps address the line-of-sight(LoS)blockage between sensor nodes(SNs)and the fusion center(FC)in Internet of Things(IoT).This paper considers an IoT assisted by multiple...UAV-mounted intelligent reflecting surface(IRS)helps address the line-of-sight(LoS)blockage between sensor nodes(SNs)and the fusion center(FC)in Internet of Things(IoT).This paper considers an IoT assisted by multiple UAVs-mounted IRS(U-IRS),where the data from ground SNs are transmitted to the FC.In practice,energy efficiency(EE)and mission completion time are crucial metrics for evaluating system performance and operational costs.Recognizing their importance during data collection,we formulate a multi-objective optimization problem to maximize EE and minimize total mission completion time simultaneously.To characterize this tradeoff while considering optimization objective consistency,we construct an optimization problem that minimizes the weighted sum of the total mission completion time and the reciprocal of EE.Due to the non-convex nature of the formulated problem,obtaining optimal solutions is generally challenging.To tackle this issue,we decompose it into three subproblems:UAV-SN association,number of reflecting elements allocation,andUAVtrajectory optimization.An iterative algorithmcombining genetic algorithm,CS-BJ algorithm,and successive convex approximation technique is proposed to solve these sub-problems.Simulation results demonstrate that when the transmitted data amount is 10 and 30Mbits,compared to the static collection benchmark(the UAV hovers directly above each SN),the EE of the proposed method improves by more than 10.4% and 5.2%,while the total mission completion time is reduced by more than 5.4% and 3.3%,respectively.展开更多
Sign language is a primary mode of communication for individuals with hearing impairments,conveying meaning through hand shapes and hand movements.Contrary to spoken or written languages,sign language relies on the re...Sign language is a primary mode of communication for individuals with hearing impairments,conveying meaning through hand shapes and hand movements.Contrary to spoken or written languages,sign language relies on the recognition and interpretation of hand gestures captured in video data.However,sign language datasets remain relatively limited compared to those of other languages,which hinders the training and performance of deep learning models.Additionally,the distinct word order of sign language,unlike that of spoken language,requires context-aware and natural sentence generation.To address these challenges,this study applies data augmentation techniques to build a Korean Sign Language dataset and train recognition models.Recognized words are then reconstructed into complete sentences.The sign recognition process uses OpenCV and MediaPipe to extract hand landmarks from sign language videos and analyzes hand position,orientation,and motion.The extracted features are converted into time-series data and fed into a Long Short-Term Memory(LSTM)model.The proposed recognition framework achieved an accuracy of up to 81.25%,while the sentence generation achieved an accuracy of up to 95%.The proposed approach is expected to be applicable not only to Korean Sign Language but also to other low-resource sign languages for recognition and translation tasks.展开更多
This paper uses a complete washing and sieving method and accurately determines the clay mass contents in the loess deposits at the eight regions of Xianyang,Ili,Xi'an,Yan'an,Lvliang,Linfen,Xining,and Lanzhou ...This paper uses a complete washing and sieving method and accurately determines the clay mass contents in the loess deposits at the eight regions of Xianyang,Ili,Xi'an,Yan'an,Lvliang,Linfen,Xining,and Lanzhou in China.The method uses nylon cloth sieves with apertures from 0.0008 mm to 0.048 mm and standard steel sieves with apertures from 0.063 mm to 28 mm.It uses a rotary vibration machine to wash and sieve the loess into many clay,silt,sand,and gravel subgroups.The masses of the separated materials construct the complete mass-based particle size distribution(PSD)curves for the tested loesses.The results show that the Xianyang,Ili,Xi'an,Yan'an,Lvliang,Linfen,Xining,and Lanzhou loesses contain 65.28%,56.73%,56.76%,38.7%,31.78%,30.55%,30.1%,and 26.29%clay in mass.These clay contents are 1.3-14.9 times higher than the clay contents from the past publications for the eight types of loess.On the other hand,the plasticity data in past publications show that loess belongs to the clay type of soil.The clay contents in the publications are underestimated,which is caused by the inseparability of fine soils(or clay and silt mixture)from the existing PSD test methods.Macro-photographs,micro-photographs and SEM photographs present the separated materials of individual clay,silt,sand,and gravel particles.Particle sizes measured from the SEM photographs confirm their particle sizes within their size limits.The clay particles exhibit strong internal cohesion,while the silt,sand,and gravel particles are individual and non-cohesive.Atterberg limits test results further demonstrate the clay particles'high plasticity features and the silt particles'non-plasticity features.展开更多
When patients initially present with atrial fibrillation along with an enlarged heart and heart failure, followed by atrioventricular block, it's essential to consider genetic factors.^([1])Genetic testing can off...When patients initially present with atrial fibrillation along with an enlarged heart and heart failure, followed by atrioventricular block, it's essential to consider genetic factors.^([1])Genetic testing can offer crucial diagnostic evidence, aiding in prognosis assessment and the adoption of appropriate treatment strategies.展开更多
Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury level.However,because of prolonged inactivity,initial attempts to activate these...Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury level.However,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface electromyography.In this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord injury.Eleven patients with chronic complete thoracic spinal cord injury were recruited.Surface electromyography data from eight major leg muscles were acquired and compared before and after the passive activity protocol.The results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of activation.Although the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically significant.These findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.展开更多
Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction(OER).Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under ...Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction(OER).Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER process.However,most of them undergo incomplete reconstruction with limited thickness of reconstruction layer,leading to low component utilization and arduous exploration of real catalytic mechanism.Herein,we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OER.The hollow phytic acid(PA)cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability,in favor of the fast and complete reconstruction.A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co(Fe)(OH)xand subsequent potential-driven oxidation to Co(Fe)OOH.The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm^(-2)and a long-term stability.The experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER activity.The work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.展开更多
Objective:Neoadjuvant therapy(NAT)has become the standard treatment option for patients with locally advanced breast cancer.How to non-invasively screen out patients with pathological complete response(pCR)after NAT h...Objective:Neoadjuvant therapy(NAT)has become the standard treatment option for patients with locally advanced breast cancer.How to non-invasively screen out patients with pathological complete response(pCR)after NAT has become an urgent world-wide clinical problem.Our work aims to the assessment of neoadjuvant treatment response in breast cancer patients for higher accuracy prediction using innovative artificial intelligence system.Methods:In this study,we retrospectively collected longitudinal(pre-NAT and post-NAT)multi-parametric magnetic resonance imaging(MRI)and clinicopathologic data of a total of 1,315 breast cancer patients(clinical stageⅠ-Ⅲ)who had undergone NAT followed by standard surgery and treated across 5 independent medical centers from January 2010 to January 2023.We used radiomics,3D convolutional neural network technology and clinical data statistical analysis methods to extract and screen multimodal features,and then developed and validated a Clinical-Radiomics-Deep-Learning(CRDL)model to predict patients'pCR outcomes based on multimodal fusion features.Results:We use the area under the receiver operating characteristic curve(AUC)in the primary cohort(PC)and3 external validation cohorts(VC_(1-3))to evaluate the model performance.The results showed that the AUC in the PC composed of 2 medical centers was 0.947[95%confidence interval(95%CI):0.931-0.960],and the AUC values in VC_(1-3)were 0.857(95%CI:0.810-0.901),0.883(95%CI:0.841-0.918)and 0.904(95%CI:0.860-0.941),respectively.Conclusions:The CRDL model demonstrated high accuracy and robustness in predicting pCR to NAT using multimodal fusion data.This study provides a strong foundation for non-invasive assessment of pCR status in breast cancer patients following NAT and offers critical insights to guide clinical decision-making in post-NAT treatment planning.展开更多
Objective Current autosomal short tandem repeat(STR)assays can analyze the zygotic composition by comparing the allelic genes at each locus of complete hydatidiform moles(CHM),with a maternal genotype serving as an es...Objective Current autosomal short tandem repeat(STR)assays can analyze the zygotic composition by comparing the allelic genes at each locus of complete hydatidiform moles(CHM),with a maternal genotype serving as an essential reference for comparative analysis.However,their application in pathology represents a challenge because of deficiency or contamination of maternal-origin tissues.This study aimed to develop a novel STR genotyping method for identifying CHM genotypes without a maternal component.Methods Samples with the pathologic description of molar pregnancy were collected.Routine hematoxylin–eosin(HE)staining and p57 immunohistochemistry staining were conducted in accordance with standard guidelines.A novel 26-plex system was explored to classify CHM and diploid pregnancies.The system combined 22 STRs on chromosomes 21/18/13/X,3 sex loci,and 1 quality control marker(TAF9L),enabling molecular diagnosis in the absence of maternal tissue.At last,traditional DNA typing based on villi and decidua(maternal component)of each case was used for result consistency analysis.Results CHM and nonmolar abortus could not be distinguished by the basic HE staining with no fetal evidence or other prominent features.DNA typing was successfully processed for all cases according to the novel 26-plex and traditional system.CHM(46XX)diagnosis required single A-STR/X-STR peaks and absent Y-chromosome markers,excluding chromosomal abnormalities via TAF9L analysis.When the villous tissue analysis revealed single peaks at X-STR/SRY loci,a 1:1 amelogenin ratio,and a 2:1 TAF9L peak ratio,these results overlapped with those of 46XY hydropic abortus or CHM.Notably,p57 immunohistochemical staining resolved the ambiguity.Consistency with traditional DNA genotyping confirmed system accuracy.This multiplex assay enhanced reliability in mole diagnosis,supporting clinical differentiation and genetic counseling.Conclusion This study presents a rapid and cost-effective assay for the genotypic identification of CHM without the need for a maternal component.The method combined the characteristics of STR loci distributed across different chromosomes and developed the clinic application of forensic biomarkers.展开更多
Background The potential of exercise as a concurrent therapy for actively treated primary tumors has been suggested by emerging preclinical and observational studies.However,clinical trials regarding this question are...Background The potential of exercise as a concurrent therapy for actively treated primary tumors has been suggested by emerging preclinical and observational studies.However,clinical trials regarding this question are scarce.Therefore,we conducted a randomized controlled trial investigating the effects of aerobic or resistance exercise concomitant to neoadjuvant chemotherapy(NACT)on tumor size.Methods In the BENEFIT study(German title:Bewegung bei neoadjuvanter chemotherapie zur verbesserung der fitness),patients with breast cancer scheduled for NACT were randomly assigned to supervised resistance training(RT,n=60)or aerobic training(AT,n=60)twice weekly during NACT or to a waitlist control group(WCG,n=60).The primary outcome,“change in tumor size”,as well as the secondary clinical outcomes pathologic complete response(pCR),type of surgery(breast conserving/mastectomy),axillary lymph node dissection(ALND,yes/no),premature discontinuation of chemotherapy(yes/no),and relative dose intensity(RDI)were derived from clinical records.Due to the highly skewed distribution,the primary outcome was categorized.Multiple(ordinal)logistic regression analyses were performed.Results Overall,there was no significant difference in post-intervention tumor size between RT or AT and WCG.However,there was a significant effect modification by hormone receptor(HR)status(P_(interaction)=0.030).Among patients with HR+tumors,results suggest a beneficial effect of AT on tumor shrinkage(odds ratio(OR)=2.37,95%confidence interval(95%CI):0.97‒5.78),on pCR(OR=3.21,95%CI:0.97‒10.61);and on ALND(OR=3.76,95%CI:0.78‒18.06)compared to WCG.The effects of RT were slightly less pronounced.For HR−subtypes,beneficial effects on RDI were found for AT(OR=3.71,95%CI:1.20‒11.50)and similarly for RT(OR=2.58,95%CI:0.88‒7.59).Both AT and RT had favorable effects on premature discontinuation of chemotherapy(OR(no vs.yes)=2.34,95%CI:1.10‒5.06),irrespective of tumor receptor status.Conclusion While there was no significant effect on the primary outcome in the overall group,aerobic and resistance exercise concomitant to NACT seem to beneficially affect tumor shrinkage and pCR,reduce the need for ALND among patients with HR+breast cancers,and prevent low RDI among patients with HR–breast cancers.These results warrant confirmation in further trials.展开更多
BACKGROUND Recently,several endoscopic techniques have been used to improve the R0 resection rate of rectal neuroendocrine neoplasms(R-NENs).However,none of these methods can achieve 100%complete resection(CR),particu...BACKGROUND Recently,several endoscopic techniques have been used to improve the R0 resection rate of rectal neuroendocrine neoplasms(R-NENs).However,none of these methods can achieve 100%complete resection(CR),particularly in the vertical direction.Endoscopic full-thickness resection(EFTR)has proven to be an effective method for the treatment of submucosal tumors but is seldom utilized in the eradication of R-NENs.AIM To review cases of R-NENs removed using EFTR and to evaluate the safety and efficacy of this technique.METHODS This retrospective cohort study enrolled 160 patients with pathologically confirmed R-NENs,including 132 who underwent endoscopic submucosal dissection(ESD)and 28 who underwent EFTR.Lesions were categorized as<1 cm,1-2 cm,and>2 cm in size.CR rate,en bloc resection rate,operation time,and complications were evaluated.Subgroup analyses and follow-up were also performed.RESULTS EFTR achieved 100%CR rates for lesions<1 cm and 1-2 cm,compared with 67.0%and 50.0%,respectively,in the ESD group.En bloc resection and successful removal of the R-NENs were achieved in all patients.Meanwhile,EFTR showed performance comparable to ESD in terms of operation time,hospitalization cost,and postoperative adverse events,except for a one-day longer hospital stay.We also analyzed the invasion depth of R-NENs based on full-thickness specimens.The data showed that 80%of lesions(<1 cm)and 85.7%of lesions(1-2 cm)had invaded the SM3 level or deeper at the time of resection.For ESD specimens,46.6%(<1 cm)and 89.3%(1-2 cm)of lesions had infiltrated more than 2000μm beneath the muscularis mucosae.CONCLUSION EFTR has shown superior performance in the resection of small R-NENs compared with that of ESD.展开更多
The undrained mechanical behavior of unsaturated completely weathered granite(CWG)is highly susceptible to alterations in the hydraulic environment,particularly under uniaxial loading conditions,due to the unique natu...The undrained mechanical behavior of unsaturated completely weathered granite(CWG)is highly susceptible to alterations in the hydraulic environment,particularly under uniaxial loading conditions,due to the unique nature of this soil type.In this study,a series of unconfined compression tests were carried out on unsaturated CWG soil in an underground engineering site,and the effects of varying the environmental variables on the main undrained mechanical properties were analyzed.Based on the experimental results,a novel constitutive model was then established using the damage mechanics theory and the undetermined coefficient method.The results demonstrate that the curves of remolded CWG specimens with different moisture contents and dry densities exhibited diverse characteristics,including brittleness,significant softening,and ductility.As a typical indicator,the unconfined compression strength of soil specimens initially increased with an increase in moisture content and then decreased.Meanwhile,an optimal moisture content of approximately 10.5%could be observed,while a critical moisture content value of 13.0%was identified,beyond which the strength of the specimen decreases sharply.Moreover,the deformation and fracture of CWG specimens were predominantly caused by shear failure,and the ultimate failure modes were primarily influenced by moisture content rather than dry density.Furthermore,by comparing several similar models and the experimental data,the proposed model could accurately replicate the undrained mechanical characteristics of unsaturated CWG soil,and quantitatively describe the key mechanical indexes.These findings offer a valuable reference point for understanding the underlying mechanisms,anticipating potential risks,and implementing effective control measures in similar underground engineering projects.展开更多
Lactiplantibacillus plantarum MWFLp-182 was originally isolated from the feces of long-living elderly individuals in Hezhou city,Guangxi,China.L.plantarum MWFLp-182 showed favorable gastric and intestinal tolerance co...Lactiplantibacillus plantarum MWFLp-182 was originally isolated from the feces of long-living elderly individuals in Hezhou city,Guangxi,China.L.plantarum MWFLp-182 showed favorable gastric and intestinal tolerance compared with Lactiplantibacillus rhamnosus GG(LGG).L.plantarum MWFLp-182 was further examined for its antioxidant and anti-inflammatory activity in ABAP-treated HT-29 cells.Importantly,it enhanced the expression of anti-inflammatory factor(interleukin-10(IL-10)),antioxidant cytokines(superoxide dismutase(SOD),glutathione peroxidase(GPx),nuclear factor erythroid 2-related factor(Nrf2),and hemeoxygenase 1(HO-1)),B-cell lymphoma-2(Bcl-2),and tight junction(Zonula occludens protein 1(ZO-1),Claudin-1,and Occludin)proteins and genes,and reduced reactive oxygen species(ROS).The complete genome of L.plantarum MWFLp-182 contained a single circular chromosome that was 3257196 bp long,with a G+C content of 44.49%,and a single circular plasmid that was 53560 bp long.The genes tpx,trx A,trx B,npr,nrd H,dps,rec A,gpx,gsh A and ars C in this strain were related to antioxidant function;the key genes involved in antioxidant function were further investigated.In this study,we identified a probiotic candidate with antioxidant properties.展开更多
The level 3 case for Ramanujan-type series has been considered as the most mysterious and the most challenging,out of all possible levels for Ramanujan-type series.This motivates the development of new techniques for ...The level 3 case for Ramanujan-type series has been considered as the most mysterious and the most challenging,out of all possible levels for Ramanujan-type series.This motivates the development of new techniques for constructing Ramanujan-type series of level 3.Chan and Liaw introduced an alternating analogue of the Borwein brothers’identity for Ramanujan-type series of level 3;subsequently,Chan,Liaw,and Tian formulated another proof of the Chan–Liaw identity,via the use of Ramanujan’s class invariant.Using the elliptic lambda function and the elliptic alpha function,we prove,via a limiting case of the Kummer–Goursat transformation,a new identity for evaluating the summands for alternating Ramanujan-type series of level 3,and we apply this new identity to prove three conjectured formulas for quadratic-irrational,Ramanujan-type series that had been discovered via numerical experiments with Maple in 2012 by Aldawoud.We also apply our identity to prove a new Ramanujan-type series of level 3 with a quartic convergence rate and quartic coefficients.展开更多
文摘THE theory of nilpotent Lie algebra is very important in the theory of finite-dimensional Lie al-gebras. Because of its extraordinary complexity, one usually studies various classes of specialnilpotent Lie algebras. In the study of complete Lie algebras, a class of special nilpotent Lie al-gebras (called completable nilpotent Lie algebras) was discovered. In this letter, we will
基金Supported by NSFC (No.12401024)the Scientific Research Innovation Project of Lingnan Normal University (Nos.LT2401,LT2410)。
文摘Let T_(n) and S_(n) be the full transformation semigroup and the symmetric group on X_(n)={1,2,...,n},respectively.Let G be a transitiveimprimitive subgroupof S_(n) with nontrivial blocksΔand letαbe a transformation in T_(n)\S_(n).The kernel ofαis the partition of X_(n) induced by the equivalence relation{(x,y)|xα=yα};the kernel type ofαis the partition of n given by the sizes of the parts of the kernel.A transformation semigroup is called synchronizing if it contains a constant map.Then a group G synchronizes a transformationαif the semigroup(G,α)contains a constant map.In this paper,we study a transitive imprimitive permutation group G together with a non-invertible transformationαthat generate a synchronizing semigroup.We mainly discuss 7 cases where G synchronizes a special transformationαwith each kernel class A_(i)(A_(1)j)satisfying|A_(i)∩Δ|=1(|A_(1)j∩Δ|=1)for all blocksΔofG,that is,the kernel type ofαis(|A_(1)|,1,...,1),(|A_(1)1|,...,|A_(1m)|,|A_(2)|,...,|Ar|),or(|A_(1)|,...,|A_(t)|,1,...,1),or the rank is 2,3,4,or n-2.
文摘In this paper,we give the double inequalities of a special quasi-arithmetic mean E(a,b)and the Seifert-like elliptic integral mean V(a,b)under the combination of generalized Heronian mean Hw(a,b),harmonic mean H(a,b)and arithmetic mean A(a,b).As applications,we obtain two new optimal bounds for the second kind of complete elliptic integral".Finally,numerical experiments are performed to compare these with some known bounds of",and the improved effect is verified.
文摘We discuss a class of filiform Lie superalgebras Ln,m. From these Lie superalgebras, all the other filiform Lie superalgebras can be obtained by deformations. We have decompositions of Der0（Ln,m） and Dery（Ln,m）. By computing a maximal torus on each Ln,m, we show that Ln,m are completable nilpotent Lie superalgebras. We also view Ln,m as Lie algebras, prove that Ln,m are of maximal rank, and show that Ln,m are completable nilpotent Lie algebras. As an application of the results, we show a Heisenberg superalgebra is a completable nilpotent Lie superalgebra.
文摘International Journal of Minerals,Metallurgy and Materials is dedicated to the publication and the dissemination of original research articles (and occasional invited reviews) in the fields of Minerals,Metallurgy and Materials.It is covered by EI Compendex,SCI Expanded,Chemical Abstract,etc.Manuscript preparation The following components are required for a complete manuscript:Title,Author(s),Author affiliation(s),Abstract,Keywords,Main text,Acknowledgements and References.
文摘BACKGROUND Sorafenib has been the conventional treatment for advanced hepatocellular carcinoma(HCC)since 2008.While radiological complete responses are extremely rare,improved supportive care and multidisciplinary approaches in clinical practice may explain the recent increase in case reports and retrospective series documenting such responses.CASE SUMMARY This case series describes 3 patients with advanced HCC who achieved durable complete responses using first-line sorafenib therapy,even in the presence of portal vein thrombosis or extrahepatic spread,and highlights the potential for sustained remission in selected patients.Dermatologic toxicity and non-viral etiology may correlate with favorable outcomes;however,reliable predictive biomarkers for sorafenib response are lacking.CONCLUSION Future research into the etiology and molecular differences in HCC is necessary to develop more personalized therapy options.
基金supported by grants from National Science and Technology Major Project(Grant No.2025ZD0544000)National Natural Science Foundation of China(Grant No.82171898)+2 种基金Deng Feng Project of High-level Hospital Construction(Grant No.DFJHBF202109)Beijing Science and Technology Innovation Medical Development Foundation(Grant No.KC2023-JX-0270-09)Development Center for Medical Science&Technology National Health commission of the People’s Republic of China(Grant No.WKZX2025RL0130)。
文摘Breast cancer exhibits profound biological and spatial heterogeneity,which contributes to variable responses to neoadjuvant chemotherapy(NAC)and challenges precision treatment planning.Radiomics,an emerging discipline that converts standard medical images into high-dimensional quantitative data,offers a non-invasive and reproducible means to capture tumor phenotype,heterogeneity,and treatment-induced changes.This review provides a comprehensive overview of recent advances in radiomics for breast cancer NAC,emphasizing the roles in predicting a pathologic complete response(pCR),monitoring early therapeutic efficacy,and quantifying intratumoral heterogeneity.Among imaging modalities,magnetic resonance imaging(MRI)-based radiomics,particularly utilizing dynamic contrast-enhanced and diffusion-weighted sequences,demonstrates robust predictive performance for the pCR,with multi-center studies reporting area under the curve(AUC)values>0.80.Longitudinal and delta-radiomics approaches further enhance early response evaluation by tracking temporal alterations in imaging features that precede measurable morphologic regression.Radiomic assessment of tumor heterogeneity,especially in triple-negative breast cancer(TNBC),reveals strong associations with immune infiltration,metabolic reprogramming,and therapeutic resistance,providing mechanistic insight into radiomic biomarkers.Integrative multi-omics frameworks,combining radiomics with genomics,transcriptomics and pathomics,are increasingly elucidating the biological underpinnings of imaging phenotypes,improving both model interpretability and clinical relevance.Despite these advances,widespread clinical adoption of radiomics is limited by methodologic variability,lack of standardization,and insufficient external validation.Future efforts should focus on harmonized imaging protocols,explainable artificial intelligence,and prospective multi-center trials to translate radiomics into a clinically actionable tool.Collectively,radiomics represents a transformative approach for individualized response prediction and dynamic treatment optimization in precision breast cancer management(Figure 1).
基金supported in part by the Opening Project of Guangxi Wireless Broadband Communication and Signal Processing Key Laboratory under Grant AD25069102in part by the Basic Ability Improvement Project of Young and Middle Aged Teachers in Guangxi Universities,under Grant 2023KY0226+6 种基金in part by Key Laboratory of Cognitive Radio and Information Processing,Ministry of Education of China,underGrant CRKL220108in part by the Innovation Project of Guangxi Graduate Education,under Grant YCBZ2023131in part by the Doctoral Research Foundation of Guilin University of Electronic Technology,under Grant UF23038Yin part by the Bagui Youth Top Talent Projectin part by the Guangxi Key Research and Development Program under Grant AB25069510in part by Open Fund of IPOC(BUPT),No.IPOC2024B07in part by Guangxi Key Laboratory of Precision Navigation Technology and Application,under Grant DH202309.
文摘UAV-mounted intelligent reflecting surface(IRS)helps address the line-of-sight(LoS)blockage between sensor nodes(SNs)and the fusion center(FC)in Internet of Things(IoT).This paper considers an IoT assisted by multiple UAVs-mounted IRS(U-IRS),where the data from ground SNs are transmitted to the FC.In practice,energy efficiency(EE)and mission completion time are crucial metrics for evaluating system performance and operational costs.Recognizing their importance during data collection,we formulate a multi-objective optimization problem to maximize EE and minimize total mission completion time simultaneously.To characterize this tradeoff while considering optimization objective consistency,we construct an optimization problem that minimizes the weighted sum of the total mission completion time and the reciprocal of EE.Due to the non-convex nature of the formulated problem,obtaining optimal solutions is generally challenging.To tackle this issue,we decompose it into three subproblems:UAV-SN association,number of reflecting elements allocation,andUAVtrajectory optimization.An iterative algorithmcombining genetic algorithm,CS-BJ algorithm,and successive convex approximation technique is proposed to solve these sub-problems.Simulation results demonstrate that when the transmitted data amount is 10 and 30Mbits,compared to the static collection benchmark(the UAV hovers directly above each SN),the EE of the proposed method improves by more than 10.4% and 5.2%,while the total mission completion time is reduced by more than 5.4% and 3.3%,respectively.
基金supported by the Institute of Information&Communications Technoljogy Planning&Evaluation(IITP)-Innovative Human Resource Development for Local Intellectualization Program grant funded by the Korea government(MSIT)(IITP-2026-RS-2022-00156334,50%)the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(No.2021R1C1C2011105,50%).
文摘Sign language is a primary mode of communication for individuals with hearing impairments,conveying meaning through hand shapes and hand movements.Contrary to spoken or written languages,sign language relies on the recognition and interpretation of hand gestures captured in video data.However,sign language datasets remain relatively limited compared to those of other languages,which hinders the training and performance of deep learning models.Additionally,the distinct word order of sign language,unlike that of spoken language,requires context-aware and natural sentence generation.To address these challenges,this study applies data augmentation techniques to build a Korean Sign Language dataset and train recognition models.Recognized words are then reconstructed into complete sentences.The sign recognition process uses OpenCV and MediaPipe to extract hand landmarks from sign language videos and analyzes hand position,orientation,and motion.The extracted features are converted into time-series data and fed into a Long Short-Term Memory(LSTM)model.The proposed recognition framework achieved an accuracy of up to 81.25%,while the sentence generation achieved an accuracy of up to 95%.The proposed approach is expected to be applicable not only to Korean Sign Language but also to other low-resource sign languages for recognition and translation tasks.
基金supported by grants from the Research Grant Council of the Hong Kong Special Administra-tive Region,China(Project Nos.HKU 17207518 and R5037-18).
文摘This paper uses a complete washing and sieving method and accurately determines the clay mass contents in the loess deposits at the eight regions of Xianyang,Ili,Xi'an,Yan'an,Lvliang,Linfen,Xining,and Lanzhou in China.The method uses nylon cloth sieves with apertures from 0.0008 mm to 0.048 mm and standard steel sieves with apertures from 0.063 mm to 28 mm.It uses a rotary vibration machine to wash and sieve the loess into many clay,silt,sand,and gravel subgroups.The masses of the separated materials construct the complete mass-based particle size distribution(PSD)curves for the tested loesses.The results show that the Xianyang,Ili,Xi'an,Yan'an,Lvliang,Linfen,Xining,and Lanzhou loesses contain 65.28%,56.73%,56.76%,38.7%,31.78%,30.55%,30.1%,and 26.29%clay in mass.These clay contents are 1.3-14.9 times higher than the clay contents from the past publications for the eight types of loess.On the other hand,the plasticity data in past publications show that loess belongs to the clay type of soil.The clay contents in the publications are underestimated,which is caused by the inseparability of fine soils(or clay and silt mixture)from the existing PSD test methods.Macro-photographs,micro-photographs and SEM photographs present the separated materials of individual clay,silt,sand,and gravel particles.Particle sizes measured from the SEM photographs confirm their particle sizes within their size limits.The clay particles exhibit strong internal cohesion,while the silt,sand,and gravel particles are individual and non-cohesive.Atterberg limits test results further demonstrate the clay particles'high plasticity features and the silt particles'non-plasticity features.
基金Military Healthcare Special Scientific Research Project(25BJZ31, awarded to SHI XM)。
文摘When patients initially present with atrial fibrillation along with an enlarged heart and heart failure, followed by atrioventricular block, it's essential to consider genetic factors.^([1])Genetic testing can offer crucial diagnostic evidence, aiding in prognosis assessment and the adoption of appropriate treatment strategies.
基金supported by the Fundamental Research Funds for Central Public Welfare Research Institute,No.2020CZ-5(to WS and GS)the National Natural Science Foundation of China,No.31970970(to JSR)Fundamental Research Funds for the Central Universities,No.YWF-23-YG-QB-010(to JSR)。
文摘Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury level.However,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface electromyography.In this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord injury.Eleven patients with chronic complete thoracic spinal cord injury were recruited.Surface electromyography data from eight major leg muscles were acquired and compared before and after the passive activity protocol.The results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of activation.Although the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically significant.These findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.
基金National Natural Science Foundation of China(22478310,U21A20286 and 22206054)。
文摘Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction(OER).Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER process.However,most of them undergo incomplete reconstruction with limited thickness of reconstruction layer,leading to low component utilization and arduous exploration of real catalytic mechanism.Herein,we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OER.The hollow phytic acid(PA)cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability,in favor of the fast and complete reconstruction.A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co(Fe)(OH)xand subsequent potential-driven oxidation to Co(Fe)OOH.The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm^(-2)and a long-term stability.The experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER activity.The work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.
基金supported by the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(No.2023-JKCS-23)the Special Research Fund for Central Universities,Peking Union Medical College[No.2022-I2M-C&T-A-014,CAMS Innovation Fund for Medical Sciences(CIFMS)]。
文摘Objective:Neoadjuvant therapy(NAT)has become the standard treatment option for patients with locally advanced breast cancer.How to non-invasively screen out patients with pathological complete response(pCR)after NAT has become an urgent world-wide clinical problem.Our work aims to the assessment of neoadjuvant treatment response in breast cancer patients for higher accuracy prediction using innovative artificial intelligence system.Methods:In this study,we retrospectively collected longitudinal(pre-NAT and post-NAT)multi-parametric magnetic resonance imaging(MRI)and clinicopathologic data of a total of 1,315 breast cancer patients(clinical stageⅠ-Ⅲ)who had undergone NAT followed by standard surgery and treated across 5 independent medical centers from January 2010 to January 2023.We used radiomics,3D convolutional neural network technology and clinical data statistical analysis methods to extract and screen multimodal features,and then developed and validated a Clinical-Radiomics-Deep-Learning(CRDL)model to predict patients'pCR outcomes based on multimodal fusion features.Results:We use the area under the receiver operating characteristic curve(AUC)in the primary cohort(PC)and3 external validation cohorts(VC_(1-3))to evaluate the model performance.The results showed that the AUC in the PC composed of 2 medical centers was 0.947[95%confidence interval(95%CI):0.931-0.960],and the AUC values in VC_(1-3)were 0.857(95%CI:0.810-0.901),0.883(95%CI:0.841-0.918)and 0.904(95%CI:0.860-0.941),respectively.Conclusions:The CRDL model demonstrated high accuracy and robustness in predicting pCR to NAT using multimodal fusion data.This study provides a strong foundation for non-invasive assessment of pCR status in breast cancer patients following NAT and offers critical insights to guide clinical decision-making in post-NAT treatment planning.
基金supported by the Key Research and Development Program of Shaanxi(No.S2024-YF-YB-SF-1359).
文摘Objective Current autosomal short tandem repeat(STR)assays can analyze the zygotic composition by comparing the allelic genes at each locus of complete hydatidiform moles(CHM),with a maternal genotype serving as an essential reference for comparative analysis.However,their application in pathology represents a challenge because of deficiency or contamination of maternal-origin tissues.This study aimed to develop a novel STR genotyping method for identifying CHM genotypes without a maternal component.Methods Samples with the pathologic description of molar pregnancy were collected.Routine hematoxylin–eosin(HE)staining and p57 immunohistochemistry staining were conducted in accordance with standard guidelines.A novel 26-plex system was explored to classify CHM and diploid pregnancies.The system combined 22 STRs on chromosomes 21/18/13/X,3 sex loci,and 1 quality control marker(TAF9L),enabling molecular diagnosis in the absence of maternal tissue.At last,traditional DNA typing based on villi and decidua(maternal component)of each case was used for result consistency analysis.Results CHM and nonmolar abortus could not be distinguished by the basic HE staining with no fetal evidence or other prominent features.DNA typing was successfully processed for all cases according to the novel 26-plex and traditional system.CHM(46XX)diagnosis required single A-STR/X-STR peaks and absent Y-chromosome markers,excluding chromosomal abnormalities via TAF9L analysis.When the villous tissue analysis revealed single peaks at X-STR/SRY loci,a 1:1 amelogenin ratio,and a 2:1 TAF9L peak ratio,these results overlapped with those of 46XY hydropic abortus or CHM.Notably,p57 immunohistochemical staining resolved the ambiguity.Consistency with traditional DNA genotyping confirmed system accuracy.This multiplex assay enhanced reliability in mole diagnosis,supporting clinical differentiation and genetic counseling.Conclusion This study presents a rapid and cost-effective assay for the genotypic identification of CHM without the need for a maternal component.The method combined the characteristics of STR loci distributed across different chromosomes and developed the clinic application of forensic biomarkers.
基金supported by an intramural proof of concept grant of the NCT Heidelberg.
文摘Background The potential of exercise as a concurrent therapy for actively treated primary tumors has been suggested by emerging preclinical and observational studies.However,clinical trials regarding this question are scarce.Therefore,we conducted a randomized controlled trial investigating the effects of aerobic or resistance exercise concomitant to neoadjuvant chemotherapy(NACT)on tumor size.Methods In the BENEFIT study(German title:Bewegung bei neoadjuvanter chemotherapie zur verbesserung der fitness),patients with breast cancer scheduled for NACT were randomly assigned to supervised resistance training(RT,n=60)or aerobic training(AT,n=60)twice weekly during NACT or to a waitlist control group(WCG,n=60).The primary outcome,“change in tumor size”,as well as the secondary clinical outcomes pathologic complete response(pCR),type of surgery(breast conserving/mastectomy),axillary lymph node dissection(ALND,yes/no),premature discontinuation of chemotherapy(yes/no),and relative dose intensity(RDI)were derived from clinical records.Due to the highly skewed distribution,the primary outcome was categorized.Multiple(ordinal)logistic regression analyses were performed.Results Overall,there was no significant difference in post-intervention tumor size between RT or AT and WCG.However,there was a significant effect modification by hormone receptor(HR)status(P_(interaction)=0.030).Among patients with HR+tumors,results suggest a beneficial effect of AT on tumor shrinkage(odds ratio(OR)=2.37,95%confidence interval(95%CI):0.97‒5.78),on pCR(OR=3.21,95%CI:0.97‒10.61);and on ALND(OR=3.76,95%CI:0.78‒18.06)compared to WCG.The effects of RT were slightly less pronounced.For HR−subtypes,beneficial effects on RDI were found for AT(OR=3.71,95%CI:1.20‒11.50)and similarly for RT(OR=2.58,95%CI:0.88‒7.59).Both AT and RT had favorable effects on premature discontinuation of chemotherapy(OR(no vs.yes)=2.34,95%CI:1.10‒5.06),irrespective of tumor receptor status.Conclusion While there was no significant effect on the primary outcome in the overall group,aerobic and resistance exercise concomitant to NACT seem to beneficially affect tumor shrinkage and pCR,reduce the need for ALND among patients with HR+breast cancers,and prevent low RDI among patients with HR–breast cancers.These results warrant confirmation in further trials.
基金Supported by National Natural Science Foundation of China,No.82004298Jiangsu Graduate Research and Practice Innovation Program,China,No.KYCX23_2090.
文摘BACKGROUND Recently,several endoscopic techniques have been used to improve the R0 resection rate of rectal neuroendocrine neoplasms(R-NENs).However,none of these methods can achieve 100%complete resection(CR),particularly in the vertical direction.Endoscopic full-thickness resection(EFTR)has proven to be an effective method for the treatment of submucosal tumors but is seldom utilized in the eradication of R-NENs.AIM To review cases of R-NENs removed using EFTR and to evaluate the safety and efficacy of this technique.METHODS This retrospective cohort study enrolled 160 patients with pathologically confirmed R-NENs,including 132 who underwent endoscopic submucosal dissection(ESD)and 28 who underwent EFTR.Lesions were categorized as<1 cm,1-2 cm,and>2 cm in size.CR rate,en bloc resection rate,operation time,and complications were evaluated.Subgroup analyses and follow-up were also performed.RESULTS EFTR achieved 100%CR rates for lesions<1 cm and 1-2 cm,compared with 67.0%and 50.0%,respectively,in the ESD group.En bloc resection and successful removal of the R-NENs were achieved in all patients.Meanwhile,EFTR showed performance comparable to ESD in terms of operation time,hospitalization cost,and postoperative adverse events,except for a one-day longer hospital stay.We also analyzed the invasion depth of R-NENs based on full-thickness specimens.The data showed that 80%of lesions(<1 cm)and 85.7%of lesions(1-2 cm)had invaded the SM3 level or deeper at the time of resection.For ESD specimens,46.6%(<1 cm)and 89.3%(1-2 cm)of lesions had infiltrated more than 2000μm beneath the muscularis mucosae.CONCLUSION EFTR has shown superior performance in the resection of small R-NENs compared with that of ESD.
基金Project(42202318)supported by the National Natural Science Foundation of ChinaProject(252300421199)supported by the Natural Science Foundation of Henan Province,ChinaProject(2024JJ6219)supported by the Hunan Provincial Natural Science Foundation of China。
文摘The undrained mechanical behavior of unsaturated completely weathered granite(CWG)is highly susceptible to alterations in the hydraulic environment,particularly under uniaxial loading conditions,due to the unique nature of this soil type.In this study,a series of unconfined compression tests were carried out on unsaturated CWG soil in an underground engineering site,and the effects of varying the environmental variables on the main undrained mechanical properties were analyzed.Based on the experimental results,a novel constitutive model was then established using the damage mechanics theory and the undetermined coefficient method.The results demonstrate that the curves of remolded CWG specimens with different moisture contents and dry densities exhibited diverse characteristics,including brittleness,significant softening,and ductility.As a typical indicator,the unconfined compression strength of soil specimens initially increased with an increase in moisture content and then decreased.Meanwhile,an optimal moisture content of approximately 10.5%could be observed,while a critical moisture content value of 13.0%was identified,beyond which the strength of the specimen decreases sharply.Moreover,the deformation and fracture of CWG specimens were predominantly caused by shear failure,and the ultimate failure modes were primarily influenced by moisture content rather than dry density.Furthermore,by comparing several similar models and the experimental data,the proposed model could accurately replicate the undrained mechanical characteristics of unsaturated CWG soil,and quantitatively describe the key mechanical indexes.These findings offer a valuable reference point for understanding the underlying mechanisms,anticipating potential risks,and implementing effective control measures in similar underground engineering projects.
基金supported by the Natural Science Foundation of Guangxi,China(2020GXNSFBA297083)the National Natural Science Foundation of China(32072193)。
文摘Lactiplantibacillus plantarum MWFLp-182 was originally isolated from the feces of long-living elderly individuals in Hezhou city,Guangxi,China.L.plantarum MWFLp-182 showed favorable gastric and intestinal tolerance compared with Lactiplantibacillus rhamnosus GG(LGG).L.plantarum MWFLp-182 was further examined for its antioxidant and anti-inflammatory activity in ABAP-treated HT-29 cells.Importantly,it enhanced the expression of anti-inflammatory factor(interleukin-10(IL-10)),antioxidant cytokines(superoxide dismutase(SOD),glutathione peroxidase(GPx),nuclear factor erythroid 2-related factor(Nrf2),and hemeoxygenase 1(HO-1)),B-cell lymphoma-2(Bcl-2),and tight junction(Zonula occludens protein 1(ZO-1),Claudin-1,and Occludin)proteins and genes,and reduced reactive oxygen species(ROS).The complete genome of L.plantarum MWFLp-182 contained a single circular chromosome that was 3257196 bp long,with a G+C content of 44.49%,and a single circular plasmid that was 53560 bp long.The genes tpx,trx A,trx B,npr,nrd H,dps,rec A,gpx,gsh A and ars C in this strain were related to antioxidant function;the key genes involved in antioxidant function were further investigated.In this study,we identified a probiotic candidate with antioxidant properties.
基金supported by a Killam Postdoctoral Fellowship from the Killam Trusts.
文摘The level 3 case for Ramanujan-type series has been considered as the most mysterious and the most challenging,out of all possible levels for Ramanujan-type series.This motivates the development of new techniques for constructing Ramanujan-type series of level 3.Chan and Liaw introduced an alternating analogue of the Borwein brothers’identity for Ramanujan-type series of level 3;subsequently,Chan,Liaw,and Tian formulated another proof of the Chan–Liaw identity,via the use of Ramanujan’s class invariant.Using the elliptic lambda function and the elliptic alpha function,we prove,via a limiting case of the Kummer–Goursat transformation,a new identity for evaluating the summands for alternating Ramanujan-type series of level 3,and we apply this new identity to prove three conjectured formulas for quadratic-irrational,Ramanujan-type series that had been discovered via numerical experiments with Maple in 2012 by Aldawoud.We also apply our identity to prove a new Ramanujan-type series of level 3 with a quartic convergence rate and quartic coefficients.
