In this paper, the phenomenon that the variation in nutrient and water temperature could cause changes in phytoplankton growth and structure is examined; and the question of how a marine ecosystem make up the earth ec...In this paper, the phenomenon that the variation in nutrient and water temperature could cause changes in phytoplankton growth and structure is examined; and the question of how a marine ecosystem make up the earth ecosystem step by step to auto-sustain the balance between phytoplankton and nutrient supply especially Si is discussed. Three major complementary mechanisms of the earth ecosys- tem for nutrient Si, water temperature and carbon were put forward. Understanding the mechanisms nowadays would explain the why the El Nifio and La Nifia occurred, and forecast the trend of human-impacted the earth, which would alert us with proactive countermeasures.展开更多
This paper takes No.52 return uphill roadway of Yangquhe coal mine as a research project. Based on the research, especially its geological condition, indoor experiments, numerical simulation and theoretical analysis w...This paper takes No.52 return uphill roadway of Yangquhe coal mine as a research project. Based on the research, especially its geological condition, indoor experiments, numerical simulation and theoretical analysis were employed to determine the difficult coefficients of Yangquhe project. By using these means,the difficult coefficients of the deep rock engineering were determined. From a study of the effects of crustal stress and the roof mechanism on roadway stability, the transformation mechanism in Yangquhe coal mine has been determined. As a result of this research, the interactive support technology of prestressed cable mesh was developed and the technology tested in mining engineering, which proved to be feasible.展开更多
Multidrug-resistant prostate cancer,particularly castration-resistant prostate cancer,remains a marked therapeutic challenge because of poor drug bioavailability,systemic toxicity,and resistance mechanisms.Nanoparticl...Multidrug-resistant prostate cancer,particularly castration-resistant prostate cancer,remains a marked therapeutic challenge because of poor drug bioavailability,systemic toxicity,and resistance mechanisms.Nanoparticle-based codelivery systems improve targeted drug accumulation,stability,and controlled release within the tumor microenvironment.The complementary mechanisms of action of these agents include paclitaxel-induced mitotic arrest and apoptosis,and chrysin increases cytotoxicity by modulating oxidative stress,suppressing survival pathways,and overcoming drug resistance.Preclinical studies have demonstrated superior efficacy and reduced toxicity compared with those of monotherapies.Despite promising results,formulation challenges,regulatory barriers,and scalability issues must be addressed to translate this dual-drug strategy into clinical applications.Overall,the codelivery of paclitaxel-chrysin via nanocarriers represents a promising advance in the personalized treatment of resistant prostate cancer.展开更多
基金Supported by the Director’s Foundation of the Beihai Monitoring Cen-ter, the State Oceanic Administration, and Chinese Academy of Sciences (KZCX 2-207).
文摘In this paper, the phenomenon that the variation in nutrient and water temperature could cause changes in phytoplankton growth and structure is examined; and the question of how a marine ecosystem make up the earth ecosystem step by step to auto-sustain the balance between phytoplankton and nutrient supply especially Si is discussed. Three major complementary mechanisms of the earth ecosys- tem for nutrient Si, water temperature and carbon were put forward. Understanding the mechanisms nowadays would explain the why the El Nifio and La Nifia occurred, and forecast the trend of human-impacted the earth, which would alert us with proactive countermeasures.
文摘This paper takes No.52 return uphill roadway of Yangquhe coal mine as a research project. Based on the research, especially its geological condition, indoor experiments, numerical simulation and theoretical analysis were employed to determine the difficult coefficients of Yangquhe project. By using these means,the difficult coefficients of the deep rock engineering were determined. From a study of the effects of crustal stress and the roof mechanism on roadway stability, the transformation mechanism in Yangquhe coal mine has been determined. As a result of this research, the interactive support technology of prestressed cable mesh was developed and the technology tested in mining engineering, which proved to be feasible.
文摘Multidrug-resistant prostate cancer,particularly castration-resistant prostate cancer,remains a marked therapeutic challenge because of poor drug bioavailability,systemic toxicity,and resistance mechanisms.Nanoparticle-based codelivery systems improve targeted drug accumulation,stability,and controlled release within the tumor microenvironment.The complementary mechanisms of action of these agents include paclitaxel-induced mitotic arrest and apoptosis,and chrysin increases cytotoxicity by modulating oxidative stress,suppressing survival pathways,and overcoming drug resistance.Preclinical studies have demonstrated superior efficacy and reduced toxicity compared with those of monotherapies.Despite promising results,formulation challenges,regulatory barriers,and scalability issues must be addressed to translate this dual-drug strategy into clinical applications.Overall,the codelivery of paclitaxel-chrysin via nanocarriers represents a promising advance in the personalized treatment of resistant prostate cancer.
