As activated hepatic stellate cells(aHSCs)play a central role in fibrogenesis,they have become key target cells for antifibrotic treatment.Nevertheless,the therapeutic efficiency is constrained by the exosomes they se...As activated hepatic stellate cells(aHSCs)play a central role in fibrogenesis,they have become key target cells for antifibrotic treatment.Nevertheless,the therapeutic efficiency is constrained by the exosomes they secrete,which are linked to energy metabolism and continuously stimulate the activation of neighboring quiescent hepatic stellate cells(qHSCs).Herein,an intercellular communication interference strategy is designed utilizing paeoniflorin(PF)loaded and hyaluronic acid(HA)coated copper-doped ZIF-8(PF@HA-Cu/ZIF-8,PF@HCZ)to reduce energy-related exosome secretion from aHSCs,thus preserving neighboring qHSCs in a quiescent state.Simultaneously,the released copper and zinc ions disrupt key enzymes involved in glycolysis to reduce bioenergy synthesis in aHSCs,thereby promoting the reversion of aHSCs to a quiescent state and further decreasing exosome secretion.Therefore,PF@HCZ can effectively sustain both aHSCs and qHSCs in a metabolically dormant state to ultimately alleviate liver fibrosis.The study provides an enlightening strategy for interrupting exosome-mediated intercellular communication and remodeling the energy metabolic status of HSCs with boosted antifibrogenic activity.展开更多
It has been shown that the deployment of device-to-device(D2D) communication in cellular systems can provide better support for local services. However, improper design of the hybrid system may cause severe interferen...It has been shown that the deployment of device-to-device(D2D) communication in cellular systems can provide better support for local services. However, improper design of the hybrid system may cause severe interference between cellular and D2D links. In this paper, we consider transceiver design for the system employing multiple antennas to mitigate the interference. The precoder and decoder matrices are optimized in terms of sum mean squared error(MSE) and capacity, respectively. For the MSE minimization problem, we present an alternative transceiver optimization algorithm. While for the non-convex capacity maximization problem, we decompose the primal problem into a sequence of standard convex quadratic programs for efficient optimization. The evaluation of our proposed algorithms for performance enhancement of the entire D2D integrated cellular system is carried out through simulations.展开更多
This paper explores the multi-frequency independent channel interference alignment(MFC-IA) system of 3 channels and4 users,and single data stream transmit,i.e.(3×3,1)~4 system.We derive the analytic solution for(...This paper explores the multi-frequency independent channel interference alignment(MFC-IA) system of 3 channels and4 users,and single data stream transmit,i.e.(3×3,1)~4 system.We derive the analytic solution for(3×3,1)~4 MFC-IA system.Based on the analytic solution,an optimization problem is proposed aim at the optimal IA solution.Then based on such a math model,we propose a simulated annealing(SA) algorithm to search optimal IA solution.The simulation results show that the simulated annealing IA algorithm has a better sum rate performance than iterative maximize signal to interference plus noise ratio(Max-SINR) algorithm.This result can be extended to single data stream multi-antenna IA system with 3 antennas and4 users.展开更多
Delay alignment modulation(DAM)is recently proposed as an effective technique to address the intersymbol interference(ISI)issue,which circumvents the conventional channel equalization and multi-carrier transmission.Mo...Delay alignment modulation(DAM)is recently proposed as an effective technique to address the intersymbol interference(ISI)issue,which circumvents the conventional channel equalization and multi-carrier transmission.Moreover,wireless communications are vulnerable to malicious eavesdropping and attacks due to their inherent open and broadcast nature.In particular,DAM not only eliminates the ISI at the desired receiver but may also introduce ISI to other locations,and thus is quite promising for secure communications.This paper considers the near-field secure wireless communication with DAM.To gain useful insights,it is first shown that when the antenna number of Alice is much larger than the number of multipaths for Bob and Eve,the delay compensation and low-complexity path-based maximal-ratio transmission(MRT)beamforming achieve a communication free of ISI and information leakage,owing to the asymptotically orthogonal property brought by the near-field nonuniform spherical wave(NUSW).The secrecy rate performance of path-based zero-forcing(ZF)beamforming toward ISI-free communication is then evaluated.Furthermore,the path-based optimized DAM beamforming scheme is proposed to maximize the secrecy rate,by considering the general case in the presence of some tolerable ISI.As a comparison,the benchmarking scheme of the artificial noise(AN)based orthogonal frequency-division multiplexing(OFDM)is considered.Simulation results show that DAM achieves a higher secrecy rate and lower peak-to-average-power ratio(PAPR)than the AN-based OFDM.展开更多
For the performance issues of satellite transceivers suffering passive intermodulation interference,a novel and effective digital suppression algorithm is presented in this paper.In contrast to analog approaches,digit...For the performance issues of satellite transceivers suffering passive intermodulation interference,a novel and effective digital suppression algorithm is presented in this paper.In contrast to analog approaches,digital passive intermodulation（PIM） suppression approaches can be easily reconfigured and therefore are highly attractive for future satellite communication systems.A simplified model of nonlinear distortion from passive microwave devices is established in consideration of the memory effect.The multiple high-order PIM products falling into the receiving band can be described as a bilinear predictor function.A suppression algorithm based on a bilinear polynomial decorrelated adaptive filter is proposed for baseband digital signal processing.In consideration of the time-varying characteristics of passive intermodulation,this algorithm can achieve the rapidness of online interference estimation and low complexity with less consumption of resources.Numerical simulation results show that the algorithm can effectively compensate the passive intermodulation interference,and achieve a high signal-to-interference ratio gain.展开更多
基金supported by the National Natural Science of China(82273873 and 31971106,China)the Youth Science and Technology Talent Program by Tianjin(QN20230215,China)+2 种基金the National Key Research and Development Program of China(2020YFC1512304 and 2020YFC1512301,China)the Tianjin Natural Science Foundation(24JCZDJC01110 China)the Major Special Projects(0402080005,China).
文摘As activated hepatic stellate cells(aHSCs)play a central role in fibrogenesis,they have become key target cells for antifibrotic treatment.Nevertheless,the therapeutic efficiency is constrained by the exosomes they secrete,which are linked to energy metabolism and continuously stimulate the activation of neighboring quiescent hepatic stellate cells(qHSCs).Herein,an intercellular communication interference strategy is designed utilizing paeoniflorin(PF)loaded and hyaluronic acid(HA)coated copper-doped ZIF-8(PF@HA-Cu/ZIF-8,PF@HCZ)to reduce energy-related exosome secretion from aHSCs,thus preserving neighboring qHSCs in a quiescent state.Simultaneously,the released copper and zinc ions disrupt key enzymes involved in glycolysis to reduce bioenergy synthesis in aHSCs,thereby promoting the reversion of aHSCs to a quiescent state and further decreasing exosome secretion.Therefore,PF@HCZ can effectively sustain both aHSCs and qHSCs in a metabolically dormant state to ultimately alleviate liver fibrosis.The study provides an enlightening strategy for interrupting exosome-mediated intercellular communication and remodeling the energy metabolic status of HSCs with boosted antifibrogenic activity.
基金supportedin part by Science and Technology Project of State Grid Corporation of China(SGIT0000KJJS1500008)Science and Technology Project of State Grid Corporation of China:“Research and Application of Distributed Energy Resource Public Information Service Platform based on Multisource Data Fusion and Mobile Internet Technologies”Science and Technology Project of State Grid Corporation of China:“Research on communication access technology for the integration, protection, and acquisition of multiple new energy resources”
文摘It has been shown that the deployment of device-to-device(D2D) communication in cellular systems can provide better support for local services. However, improper design of the hybrid system may cause severe interference between cellular and D2D links. In this paper, we consider transceiver design for the system employing multiple antennas to mitigate the interference. The precoder and decoder matrices are optimized in terms of sum mean squared error(MSE) and capacity, respectively. For the MSE minimization problem, we present an alternative transceiver optimization algorithm. While for the non-convex capacity maximization problem, we decompose the primal problem into a sequence of standard convex quadratic programs for efficient optimization. The evaluation of our proposed algorithms for performance enhancement of the entire D2D integrated cellular system is carried out through simulations.
基金supported by the 863 Program of China under Grant No.2015AA01A703the Fundamental Research Funds for the Central Universities under Grant No.2014ZD03-02+1 种基金the National Natural Science Foundation of China(NSFC,No.61171104,61571055)fund of State Key Laboratory of Millimeter Wave(SKL of MMW,No.K201501)
文摘This paper explores the multi-frequency independent channel interference alignment(MFC-IA) system of 3 channels and4 users,and single data stream transmit,i.e.(3×3,1)~4 system.We derive the analytic solution for(3×3,1)~4 MFC-IA system.Based on the analytic solution,an optimization problem is proposed aim at the optimal IA solution.Then based on such a math model,we propose a simulated annealing(SA) algorithm to search optimal IA solution.The simulation results show that the simulated annealing IA algorithm has a better sum rate performance than iterative maximize signal to interference plus noise ratio(Max-SINR) algorithm.This result can be extended to single data stream multi-antenna IA system with 3 antennas and4 users.
基金supported by the Natural Science Foundation for Distinguished Young Scholars of Jiangsu Province,China(No.BK20240070)the National Natural Science Foundation of China(No.62071114)the Fundamental Research Funds for the Central Universities(No.2242022k60004)。
文摘Delay alignment modulation(DAM)is recently proposed as an effective technique to address the intersymbol interference(ISI)issue,which circumvents the conventional channel equalization and multi-carrier transmission.Moreover,wireless communications are vulnerable to malicious eavesdropping and attacks due to their inherent open and broadcast nature.In particular,DAM not only eliminates the ISI at the desired receiver but may also introduce ISI to other locations,and thus is quite promising for secure communications.This paper considers the near-field secure wireless communication with DAM.To gain useful insights,it is first shown that when the antenna number of Alice is much larger than the number of multipaths for Bob and Eve,the delay compensation and low-complexity path-based maximal-ratio transmission(MRT)beamforming achieve a communication free of ISI and information leakage,owing to the asymptotically orthogonal property brought by the near-field nonuniform spherical wave(NUSW).The secrecy rate performance of path-based zero-forcing(ZF)beamforming toward ISI-free communication is then evaluated.Furthermore,the path-based optimized DAM beamforming scheme is proposed to maximize the secrecy rate,by considering the general case in the presence of some tolerable ISI.As a comparison,the benchmarking scheme of the artificial noise(AN)based orthogonal frequency-division multiplexing(OFDM)is considered.Simulation results show that DAM achieves a higher secrecy rate and lower peak-to-average-power ratio(PAPR)than the AN-based OFDM.
基金supported by the National Natural SciencFoundation of China(Nos.U1636125,61601027)
文摘For the performance issues of satellite transceivers suffering passive intermodulation interference,a novel and effective digital suppression algorithm is presented in this paper.In contrast to analog approaches,digital passive intermodulation（PIM） suppression approaches can be easily reconfigured and therefore are highly attractive for future satellite communication systems.A simplified model of nonlinear distortion from passive microwave devices is established in consideration of the memory effect.The multiple high-order PIM products falling into the receiving band can be described as a bilinear predictor function.A suppression algorithm based on a bilinear polynomial decorrelated adaptive filter is proposed for baseband digital signal processing.In consideration of the time-varying characteristics of passive intermodulation,this algorithm can achieve the rapidness of online interference estimation and low complexity with less consumption of resources.Numerical simulation results show that the algorithm can effectively compensate the passive intermodulation interference,and achieve a high signal-to-interference ratio gain.
