Objective To compare the differences of therapeutic effect of chronic fatigue syndrome （CFS） treated with the combined therapy of Panlongci （coiling dragon needling） and cupping on back and the western medicine th...Objective To compare the differences of therapeutic effect of chronic fatigue syndrome （CFS） treated with the combined therapy of Panlongci （coiling dragon needling） and cupping on back and the western medicine therapy with prednisone. Methods Seventy-two cases were randomly divided into 2 groups of acupuncture-cupping group （37 cases） and prednisone group （35 cases）. In acupuncture-cupping group, Jiaji points （夹脊 EX-B 2） of the level of T1–L5 were applied with coiling dragon needling once a day, combining with moving cupping on back once every two days. In prednisone group, prednisone tablets of 10 mg were orally taken at 8：00 am everyday. Seven days were counted as one treatment course, and 2 courses were carried on totally. FS-14 scale and BELL’s CFS integral table were applied to evaluate the fatigue degree of patients before and after the treatment, and the therapeutic effects of both groups were compared. Results After one course of treatment, the BELL’s scores of both groups were obviously improved （both P0.01）, but there was no significant difference between the 2 groups （P0.05）; after 2 courses of treatment, the BELL’s score in acupuncture-cupping group improved more obviously than that of the prednisone group （P0.05）, and the total effective rate of 91.9% （34/37） in acupuncture-cupping group was superior to that of 71.4% （25/35） in prednisone group （P0.05）. Conclusion The therapeutic effect of chronic fatigue syndrome treated with coiling dragon needling and moving cupping on back is positive, which is superior to that of prednisone with oral administration.展开更多
The published article titled“MicroRNA-148a Acts as a Tumor Suppressor in Osteosarcoma via Targeting Rho-Associated Coiled-Coil Kinase”has been retracted from Oncology Research,Vol.25,No.8,2017,pp.1231–1243.DOI:10.3...The published article titled“MicroRNA-148a Acts as a Tumor Suppressor in Osteosarcoma via Targeting Rho-Associated Coiled-Coil Kinase”has been retracted from Oncology Research,Vol.25,No.8,2017,pp.1231–1243.DOI:10.3727/096504017X14850134190255 URL:https://www.techscience.com/or/v25n8/56908 Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.展开更多
Coiled tube heat exchangers are widely preferred in shell structures due to their superior heat transfer performance,driven by favorable flow characteristics.This study investigates the effect of modifying coil and sh...Coiled tube heat exchangers are widely preferred in shell structures due to their superior heat transfer performance,driven by favorable flow characteristics.This study investigates the effect of modifying coil and shell configurations on heat transfer efficiency.Two key enhancements were examined:adding fins to the outer coil surface and integrating longitudinal slots within a hollowed shell.These modifications promote turbulence and extend heat transfer duration,thereby improving performance.However,they also introduce challenges,including increased pressure loss andmanufacturing complexity.Numerical simulationswere conducted usingANSYS Fluent 2024R1 under identical boundary conditions.With a fixed cold-side flow rate of 3 L/min,the input temperatures for the hot and cold fluids were 333.15 and 291.65 K,respectively.The hot-side flow rate varied between 2 and 6 L/min.Simulation outcomes were reported for the objectives of the study that included the improvement in heat exchangers’heat transfer enhancement.As it was indicated in the study outcomes,the average heat transfer rate increased by 15.56%,the overall heat transfer coefficient enhanced by about 29.51%,and the convective heat transfer coefficient improved by about 75.96%compared to the conventional shell-and-coil tube heat exchanger model.However,the modified technique resulted in a significant pressure drop.展开更多
Influence of coiling temperature(CT)on the microstructure and mechanical properties of a hot-rolled high-strength steel microalloyed with Ti,Mo and V was elucidated.The precipitation behavior of nano-sized particles w...Influence of coiling temperature(CT)on the microstructure and mechanical properties of a hot-rolled high-strength steel microalloyed with Ti,Mo and V was elucidated.The precipitation behavior of nano-sized particles was investigated by theoretical calculation and quantitative analysis.And the results revealed that V-enriched(Ti,Mo,V)C precipitated in the ferrite matrix.As the CT decreased,the site fractions of Ti in(Ti,Mo,V)C changed little,the site fractions of Mo increased,and the site fractions of V decreased accordingly.Moreover,the low CT could refine the microstructure and precipitated particles but suppress the precipitation of(Ti,Mo,V)C particles simultaneously,leading to the volume fraction of(Ti,Mo,V)C significantly decreasing,consequently causing an increment of grain refinement strengthening and a reduction in precipitation hardening.When the CT was 600℃,the steel characterized by fine polygonal ferrite,a small amount of bainite and nano-sized(Ti,Mo,V)C precipitates exhibited the optimum mechanical properties with the ultimate tensile strength of 870 MPa,yield strength of 807 MPa and elongation to fracture of 17%.展开更多
Short suspension system has an indispensable effect on vehicle handling and ride,so,optimization of vehicle suspension system is one of the most effective methods,which could considerably enhance the vehicle stability...Short suspension system has an indispensable effect on vehicle handling and ride,so,optimization of vehicle suspension system is one of the most effective methods,which could considerably enhance the vehicle stability and controllability.Motion control,stability maintenance and ride comfort improvement are fundamental issues in design of suspension system of off-road vehicles.In this work,a dependent suspension system mostly used in off-road vehicles is modeled using Trucksim software.Then,geometric parameters of suspension system are optimized using integrated anti-roll bar and coiling spring in a way that ride comfort,handling and stability of vehicle are improved.The simulation results of suspension system and variations of geometric parameters due to road roughness and different steering angles are presented in Trucksim and effects of optimization of suspension system during various driving maneuvers in both optimized and un-optimized conditions are compared.The simulation results indicate that the type of suspension system and geometric parameters have significant effect on vehicle performance.展开更多
The influences of coiling temperature and cooling condition on structural transformation of the hot-rolled tertiary oxide scale formed under continuous cooling conditions were studied by thermal gravimetric analyzer. ...The influences of coiling temperature and cooling condition on structural transformation of the hot-rolled tertiary oxide scale formed under continuous cooling conditions were studied by thermal gravimetric analyzer. The fourth oxide scale formed under different conditions were classified and plotted. Because the oxide scale structure transformation is diffusion-controlled and the transformation law is similar to ＂C＂ curve, the eutectoid transformation nose temperature is 450 ℃. Under condition of low temperature and high cooling rate, ion diffusion behavior is restricted so that the eutectoid reaction is suppressed, resulting in that the fourth oxide scale is mainly made up of pre-eutectoid Fe304 and FeO without eu- tectoid products. From scale structure transition diagram, the eutectoid reaction process was affected by coiling temperature and cooling rate, leading to various scale structures.展开更多
The microstructure characteristics and properties(especially hole expansion property)of 800 MPa hot-rolled complex phase steel with different coiling temperatures were studied.The microstructure consisted of polygonal...The microstructure characteristics and properties(especially hole expansion property)of 800 MPa hot-rolled complex phase steel with different coiling temperatures were studied.The microstructure consisted of polygonal ferrite and precipitates when the steel was coiled at 550℃,and when the steel was coiled between 460–520℃,the microstructure was composed of granular bainite and martensite and austenite(M/A)islands.The morphology of the crack was analyzed by scanning electron microscopy,and the in situ scanning electron microscope tensile test was used to find out the fracture mechanism and deformation behavior of the steel with different coiling temperatures.When the steel was coiled at 550℃,the cracks initiated at the ferrite grain boundary and propagated through the grains or along the grain boundaries.When the steel was coiled at 520℃,the cracks first initiated at the junction of ferrite and M/A island and then propagated through the grains.The steel coiled at 520℃ has quite good mechanical properties and relatively high hole expansion ratio.展开更多
Mice deficient in the transcription factor pleomorphic adenoma gene 1(PLAG1)exhibit reproductive issues that are characterized,in part,by decreased progressive sperm motility in the male.However,the underlying cause o...Mice deficient in the transcription factor pleomorphic adenoma gene 1(PLAG1)exhibit reproductive issues that are characterized,in part,by decreased progressive sperm motility in the male.However,the underlying cause of this impairment is unknown.As epididymal transit is critical for sperm maturation and motility,the morphology of the epididymis of Plag1-deficient mice was investigated and the spatial expression patterns of PLAG1 protein and mRNA were identified.Using X-gal staining and in situ hybridization,PLAG1 was shown to be widely expressed in both the epithelium and stroma in all regions of the mouse epididymis.Interestingly,the X-gal staining pattern was markedly different in the cauda,where it could be suggestive of PLAG1 secretion into the epididymal lumen.At all ages investigated,the morphology of epididymides from Plag1 knockout(KO)mice was aberrant;the tubule failed to elongate and coil,particularly in the corpus and cauda,and the cauda was malformed,lacking its usual bulbous shape.Moreover,the epididymides from Plag1 KO mice were significantly reduced in size relative to body weight.In 20%of Plag1-deficient mice,the left testicle and epididymis were lacking.The impaired morphogenesis of the epididymal tubule is likely to be a major contributing factor to the fertility problems observed in male Plag1-deficient mice.These results also establish PLAG1 as an important regulator of male reproduction,not only through its involvement in testicular sperm production,but also via its role in the development and function of the epididymis.展开更多
The strength-to-weight ratio is an important property of high-strength low-alloy(HSLA)steel in pipeline,whose precipitation strengthening can be improved.The final rolling temperature(FRT)and coiling temperature(CT)ar...The strength-to-weight ratio is an important property of high-strength low-alloy(HSLA)steel in pipeline,whose precipitation strengthening can be improved.The final rolling temperature(FRT)and coiling temperature(CT)are the key process parameters in the control of precipitates and microstructure.Continuous cooling rate was fixed at 10℃/s,and the effects of deformation and coiling temperatures on precipitates and microstructure of Ti-Nb microalloyed HSLA steel were investigated through thermo-mechanical controlled processing on Gleeble 3500.The microstructure is mainly acicular ferrite with high density dislocation and several microns scale.The size and volume fraction of the precipitates were studied under transmission electron microscopy.The results showed that the diameter of the precipitates was in the range between 4 and 240 nm.The optimized combination of parameters is FRT of 820℃and CT of 550℃,and the volume fraction of precipitates obtained under this process is 0.59%.展开更多
Prompt diagnosis and therapy of aneurysms are critical for patients with nontraumatic subarachnoid hemorrhage （SAH）.The aim of our study was to assess the clinical usefulness of multislice computed tomography angiog...Prompt diagnosis and therapy of aneurysms are critical for patients with nontraumatic subarachnoid hemorrhage （SAH）.The aim of our study was to assess the clinical usefulness of multislice computed tomography angiography （CTA） in the surgical and endovascular treatment of intracranial aneurysms.A total of 195 cases with 206 intracranial aneurysms underwent CTA.Fifty （24%） aneurysms underwent surgical clipping while 156 （76%） aneurysms underwent endovascular coiling.In the five missed aneurysms at digital substraction angiography and the nine aneurysms with mass intracerebral hematomas,surgical treatment was successfully performed based on 16-slice CTA alone,and the other 36 aneurysms were clipped on the main basis of the CTA.The intraoperative findings correlated well with the CTA findings and all aneurysms were clipped successfully.Sixteen-slice CTA image information has been shown to determine the choice of aneurysm therapy and assist the surgical and endovascular treatment of intracranial aneurysms.展开更多
Background:To evaluate the efficacy of stent-assisted coiling(SAC)for the treatment of carotid ophthalmic segment aneurysm segment aneurysms(OSAs)of the internal carotid artery(ICA)through detailed long-term follow-up...Background:To evaluate the efficacy of stent-assisted coiling(SAC)for the treatment of carotid ophthalmic segment aneurysm segment aneurysms(OSAs)of the internal carotid artery(ICA)through detailed long-term follow-up of a large patient cohort.Methods:We retrospectively analyzed 88 consecutive patients with OSAs between January 2009 and January 2020 at our center.Angiographic results were evaluated using the modified Raymond grading system and clinical outcomes were evaluated using the mRS scale.The primary endpoints were major aneurysm recurrence and poor clinical outcomes for at least 18 months of follow-up.The patients were asked to attend clinical follow-up assessments and possibly undergo DSA or MR via telephone.Results:We enrolled 88 patients with 99 OSAs treated with coiling,of whom 76 were treated with SAC.The coiling procedures were successful in all 88 patients.Overall,complications occurred in 8 patients(9.1%).No procedure-related mortality was observed.67(76.1%)experienced immediate aneurysm occlusion at the end of the procedure.Long-term angiographic follow-up(18 months)was available in 45/88 aneurysms(51%)(average 18.7±5.2 months).Four patients continued their follow-up for 5 years after initial aneurysm treatment.After a clinical follow-up time of 28.7 months(range,12-51 months),85 patients(95.5%)achieved favorable clinical outcomes(mRS scores of 0-2).Conclusions:This study indicates that SAC treatment is a safe and effective therapeutic alternative for ruptured and unruptured OSAs.The procedural risks are low with relatively long-term effectiveness.展开更多
Low-carbon steel is widely used for household appliance and automotive panel steel because of its excellent plasticity.Unfortunately,yield point phenomena easily appear in the low-carbon steel produced by a continuous...Low-carbon steel is widely used for household appliance and automotive panel steel because of its excellent plasticity.Unfortunately,yield point phenomena easily appear in the low-carbon steel produced by a continuous annealing process and cause degradation to the surface quality during processing.The effect of the coiling temperature(600-750℃)and annealing temperature(740-820℃)on the yield point behavior is studied.Tensile tests show that coiling temperature has a greater effect on yield point elongation(YPE)and aging index(AI)than the annealing temperature.Microstructure observations show that coiling temperature at 750℃would make the micron-sized carbides appearing at the grain boundary disappear and a number of dispersed nanoscale carbides precipitate in grain interior,corresponding to the highest solid solution carbon content in the matrix of 750℃coiled sample.The experimental results suggest that AI rather than YPE has a positive relationship with the solid solution carbon content of the low-carbon steel.And YPE has a positive relationship with the upper/lower yield strength.展开更多
The effects of hot-strip coiling temperature on Ti（C,N） precipitation, texture and hydrogen permeation behavior in DC06 EK enamel steel were investigated by TEM, EBSD test and electrochemical hydrogen permeation exp...The effects of hot-strip coiling temperature on Ti（C,N） precipitation, texture and hydrogen permeation behavior in DC06 EK enamel steel were investigated by TEM, EBSD test and electrochemical hydrogen permeation experiment. It was found that the Ti（C,N） particles in hot-strip coarsened with increasing coiling temperature, whereas after cold-rolling and annealing, the size difference of Ti（C,N） particles was lessened. The hot-strip coiling temperature has a significant impact on the recrystallized texture in the subsequent cold-rolled and annealed sheet. Hot-strip using high temperature（700 ℃） coiling leads to strong {111} recrystallized texture in annealed sheet, with peak intensity 9.2. On the contrary, in annealed sheets using hot-strip coiling at 650 ℃, their {111} recrystallized textures were weaker, which was also reflected in their rmvalues. Even though the hydrogen diffusion coefficient is slightly lower（7.76×10^（-5） mm^2/s） in annealed sheet using low temperature coiling（600 ℃）, appropriately higher coiling temperature is more suitable for DC06 EK enamel steel combining both good drawability and fish-scale resistance.展开更多
Objective:This study aimed to evaluate the clinical and angiographic outcomes of aneurysms that were completely or near-completely embolized and ascertain whether complete embolization is important in the stent-assist...Objective:This study aimed to evaluate the clinical and angiographic outcomes of aneurysms that were completely or near-completely embolized and ascertain whether complete embolization is important in the stent-assisted coiling(SAC)of intracranial aneurysms.Methods:This retrospective study enrolled 390 patients(417 aneurysms).Among them,complete(100%)or nearcomplete(>90%)angiographic obliteration of the aneurysms on immediate angiography was accomplished.Baseline characteristics,complications,angiography follow-up results,and clinical outcomes were analyzed.Results:Cumulative adverse events occurred in 30 patients(7.7%),including thromboembolic complications in 17(4.4%),intraoperative rupture in 10(2.6%),and others in 3(0.8%).Statistical analyses revealed an increased intraprocedural rupture rate in the initial completely occluded aneurysms(5.6%compared with 1.0%).The incidence of cumulative adverse events was higher in patients with completely occluded aneurysms(11.1%)than in those with near-completely occluded aneurysms(5.5%).Angiography follow-up was available for 173 aneurysms.Aneurysm occlusion status at follow-up was correlated with stent placement(p?0.000,odds ratio?5.847),size(p?0.000,odds ratio?6.446 for tiny aneurysms;and p?0.001,odds ratio?5.616 for small aneurysms),and initial aneurysm occlusion status(p?0.001,odds ratio?3.436).Complete occlusion at followup was seen in 82.6%of the initial complete occlusion group versus 63.0%of the initial near-complete occlusion group.The incidence of complete occlusion at follow-up was higher in the initial completely occluded aneurysms with SAC(100%)than in the initial completely occluded aneurysms with non-SAC(65.2%).Conclusions:Initial complete treatment may lead to higher complication rates and good clinical outcomes at follow-up.Stent placement may enhance progressive aneurysm occlusion.Initial complete occlusion with SAC can provide durable closure at follow-up.展开更多
The effect of coiling temperatures on the evolution of texture in Ti-IF steel during ferritic hot rolling, cold rolling and annealing was studied. It was found that texture evolution at high temperature coiling is abs...The effect of coiling temperatures on the evolution of texture in Ti-IF steel during ferritic hot rolling, cold rolling and annealing was studied. It was found that texture evolution at high temperature coiling is absolutely different from that at low temperature one. The hot band texture includes a strong α-fiber as well as a weak γ-fiber after ferritic hot rolling and low temperature coiling. Both of them intensify after cold rolling and a γ-fiber with peak at {111}〈112〉 is the main texture of annealed samples. However, the main component of the hot band texture after high temperature coiling is v-fiber. After cold rolling, the intensity of γ texture reduces; α fiber （except {111}〈110〉 component） intensifies and a strong and well-proportioned γ-fiber forms in the annealed samples.展开更多
The effects of cooling rate and coiling temperature on microstructure and mechanical properties of a plain carbon steel were investigated by combining metallography and tensile experiments. The results indicate that f...The effects of cooling rate and coiling temperature on microstructure and mechanical properties of a plain carbon steel were investigated by combining metallography and tensile experiments. The results indicate that ferrite grain size is refined and bainite transformation occurs to ensure high strength and elongation, as the cooling rate is quick enough. Yield strength and tensite strength improve with the decreased finish cooling temperature, but the elongation decreases too significantly to meet the requirements. Thus, the cooling rate must be quick enough, and the appropriate coiling temperature should be carefully selected to obtain refined ferrite and a small amount of bainite to improve the strength while the plasticity is also ensured. Under this condition, the Mn element concentration can be reduced to save cost or produce higher strength steel with same chemical composition.展开更多
A new intelligent control scheme for hot strip coiling temperature is presented. In this scheme, the prediction mode1 of finishing temperature and the presetting model of main cooling zone are establish based on BP ne...A new intelligent control scheme for hot strip coiling temperature is presented. In this scheme, the prediction mode1 of finishing temperature and the presetting model of main cooling zone are establish based on BP neural network, the feed-forward open-loop control model of main cooling zone is constructed based on T-S fuzzy neural network, a new improved structure of T-S fuzzy neural network is developed, and the feedback close-loop control model of precision cooling zone is obtained based on fuzzy control. The effectiveness of the proposed scheme has been demonstrated by computer simulation with a satisfactory result.展开更多
It is of great significance to study the water absorption and expansion of cells,which are essential for the growth and life regulation of plants,not only for understanding the complex life phenomena of plants,but als...It is of great significance to study the water absorption and expansion of cells,which are essential for the growth and life regulation of plants,not only for understanding the complex life phenomena of plants,but also for the manufacture of biomimetic materials.The main purpose of this study is to shed light on the mechanism of a novel coiling phenomenon of the split dandelion scape soaked in water and the high concentration mannitol solution.We discovered that the difference between water absorption/dehydration capacities of inner cells and lateral cells of the split dandelion scape generates asymmetric expansion/contraction between inner and lateral layers,resulting two opposite coiled patterns.Analogous to the deformable hypothesis of the thermal expansion model,the water absorption-induced cell expansion model was proposed to explain the coiling process of the split dandelion scape.Both the simulation and experimental results revealed that the coiling of dandelion scape is strongly depended on the response of cells to the stimulation of the solution environment.Showing considerable potential load bearing capacity of plants,the coiling phenomenon can be an inspiration to the designs of soft robots and bionic sensors for humidity control.展开更多
The plant-pollinator‘arms race’model posits that a major driver of the evolution of elongated corollas in flowers is reciprocal selection for‘morphological fit’between pollinator-tongue length and access distance ...The plant-pollinator‘arms race’model posits that a major driver of the evolution of elongated corollas in flowers is reciprocal selection for‘morphological fit’between pollinator-tongue length and access distance to nectar(usually corolla-tube length).Evidence for the pollinator-mediated selection on tube length and evolution of multiple,correlated floral traits remains inconclusive.To gain possible insights into the strength of stabilizing selection by assessing standing phenotypic variation,we measured a series of functionally important floral traits,including corolla tube length and‘effective’tube depth and degree of style coiling.We then calculated coefficients of variation(CV)for these traits in three field populations of R.schneideriana.Unlike in most long-tubed flowers,the bottom part of the corolla tube is completely occupied by the style,with no room for nectar.The length of this portion of the corolla tube was more variable(higher CV)than the upper part of the corolla tube,suggesting that functional tube depth was under stronger stabilizing selection.The degree of style coiling was negatively related to the corolla-tube length in all three populations of R.schneideriana,suggesting that there may be conflicting selection acting on style length and corolla-tube length,which are otherwise usually tightly correlated.Given the lack of nectar in the flowers of this species,the long corolla tubes and long styles may represent morphological holdovers from ancestors that were pollinated by long-tongued pollinators,as is still seen in related species in the western Himalayas.展开更多
In this paper, the effect of hot-rolling processing parameters on the post-rolling transformation behavior of C-Mn-Cr-Cu weather-resistant martensitic steel was investigated.Results indicate that the post-rolling tran...In this paper, the effect of hot-rolling processing parameters on the post-rolling transformation behavior of C-Mn-Cr-Cu weather-resistant martensitic steel was investigated.Results indicate that the post-rolling transformation behavior, particularly the post-coiling transformation behavior, strongly depends on the coiling temperature.Under a high coiling temperature, ferrite/pearlite transformation was mainly observed with a low trans-formation speed and transformation dilation after coiling.With decreasing coiling temperature, the proportion of bainite transformation increased with an increased transformation speed and transformation dilation.The dependence of transformation behavior on the coiling temperature could be one of the most important reasons behind the coil collapse of the experimental steel.The optimization of hot-rolling and coiling processing parameters of the steel strip, including laminar flow cooling, coiling temperature, and suspension time on the winding machine, can signi-ficantly reduce the transformation dilation of the steel after hot rolling, thus effectively controlling the coil collapse of the steel.展开更多
文摘Objective To compare the differences of therapeutic effect of chronic fatigue syndrome （CFS） treated with the combined therapy of Panlongci （coiling dragon needling） and cupping on back and the western medicine therapy with prednisone. Methods Seventy-two cases were randomly divided into 2 groups of acupuncture-cupping group （37 cases） and prednisone group （35 cases）. In acupuncture-cupping group, Jiaji points （夹脊 EX-B 2） of the level of T1–L5 were applied with coiling dragon needling once a day, combining with moving cupping on back once every two days. In prednisone group, prednisone tablets of 10 mg were orally taken at 8：00 am everyday. Seven days were counted as one treatment course, and 2 courses were carried on totally. FS-14 scale and BELL’s CFS integral table were applied to evaluate the fatigue degree of patients before and after the treatment, and the therapeutic effects of both groups were compared. Results After one course of treatment, the BELL’s scores of both groups were obviously improved （both P0.01）, but there was no significant difference between the 2 groups （P0.05）; after 2 courses of treatment, the BELL’s score in acupuncture-cupping group improved more obviously than that of the prednisone group （P0.05）, and the total effective rate of 91.9% （34/37） in acupuncture-cupping group was superior to that of 71.4% （25/35） in prednisone group （P0.05）. Conclusion The therapeutic effect of chronic fatigue syndrome treated with coiling dragon needling and moving cupping on back is positive, which is superior to that of prednisone with oral administration.
文摘The published article titled“MicroRNA-148a Acts as a Tumor Suppressor in Osteosarcoma via Targeting Rho-Associated Coiled-Coil Kinase”has been retracted from Oncology Research,Vol.25,No.8,2017,pp.1231–1243.DOI:10.3727/096504017X14850134190255 URL:https://www.techscience.com/or/v25n8/56908 Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.
文摘Coiled tube heat exchangers are widely preferred in shell structures due to their superior heat transfer performance,driven by favorable flow characteristics.This study investigates the effect of modifying coil and shell configurations on heat transfer efficiency.Two key enhancements were examined:adding fins to the outer coil surface and integrating longitudinal slots within a hollowed shell.These modifications promote turbulence and extend heat transfer duration,thereby improving performance.However,they also introduce challenges,including increased pressure loss andmanufacturing complexity.Numerical simulationswere conducted usingANSYS Fluent 2024R1 under identical boundary conditions.With a fixed cold-side flow rate of 3 L/min,the input temperatures for the hot and cold fluids were 333.15 and 291.65 K,respectively.The hot-side flow rate varied between 2 and 6 L/min.Simulation outcomes were reported for the objectives of the study that included the improvement in heat exchangers’heat transfer enhancement.As it was indicated in the study outcomes,the average heat transfer rate increased by 15.56%,the overall heat transfer coefficient enhanced by about 29.51%,and the convective heat transfer coefficient improved by about 75.96%compared to the conventional shell-and-coil tube heat exchanger model.However,the modified technique resulted in a significant pressure drop.
基金supported by the National Key R&D Program of China(No.2017 YFB0305100)the Key Research and Development Program of Hubei Province(No.2020BAB057)the Natural Science Foundation and Major Technology Innovation of Hubei Province(No.2017AAA113).
文摘Influence of coiling temperature(CT)on the microstructure and mechanical properties of a hot-rolled high-strength steel microalloyed with Ti,Mo and V was elucidated.The precipitation behavior of nano-sized particles was investigated by theoretical calculation and quantitative analysis.And the results revealed that V-enriched(Ti,Mo,V)C precipitated in the ferrite matrix.As the CT decreased,the site fractions of Ti in(Ti,Mo,V)C changed little,the site fractions of Mo increased,and the site fractions of V decreased accordingly.Moreover,the low CT could refine the microstructure and precipitated particles but suppress the precipitation of(Ti,Mo,V)C particles simultaneously,leading to the volume fraction of(Ti,Mo,V)C significantly decreasing,consequently causing an increment of grain refinement strengthening and a reduction in precipitation hardening.When the CT was 600℃,the steel characterized by fine polygonal ferrite,a small amount of bainite and nano-sized(Ti,Mo,V)C precipitates exhibited the optimum mechanical properties with the ultimate tensile strength of 870 MPa,yield strength of 807 MPa and elongation to fracture of 17%.
文摘Short suspension system has an indispensable effect on vehicle handling and ride,so,optimization of vehicle suspension system is one of the most effective methods,which could considerably enhance the vehicle stability and controllability.Motion control,stability maintenance and ride comfort improvement are fundamental issues in design of suspension system of off-road vehicles.In this work,a dependent suspension system mostly used in off-road vehicles is modeled using Trucksim software.Then,geometric parameters of suspension system are optimized using integrated anti-roll bar and coiling spring in a way that ride comfort,handling and stability of vehicle are improved.The simulation results of suspension system and variations of geometric parameters due to road roughness and different steering angles are presented in Trucksim and effects of optimization of suspension system during various driving maneuvers in both optimized and un-optimized conditions are compared.The simulation results indicate that the type of suspension system and geometric parameters have significant effect on vehicle performance.
基金Item Sponsored by National Natural Science Foundation of China(51204047)National High Technology Research and Development Program of China(2011BAE13B04)Fundamental Research Funds for the Central Universities of China(N130407004)
文摘The influences of coiling temperature and cooling condition on structural transformation of the hot-rolled tertiary oxide scale formed under continuous cooling conditions were studied by thermal gravimetric analyzer. The fourth oxide scale formed under different conditions were classified and plotted. Because the oxide scale structure transformation is diffusion-controlled and the transformation law is similar to ＂C＂ curve, the eutectoid transformation nose temperature is 450 ℃. Under condition of low temperature and high cooling rate, ion diffusion behavior is restricted so that the eutectoid reaction is suppressed, resulting in that the fourth oxide scale is mainly made up of pre-eutectoid Fe304 and FeO without eu- tectoid products. From scale structure transition diagram, the eutectoid reaction process was affected by coiling temperature and cooling rate, leading to various scale structures.
基金This work was supported by the Foundation of China Electric Power Research Institute(No.51601174).
文摘The microstructure characteristics and properties(especially hole expansion property)of 800 MPa hot-rolled complex phase steel with different coiling temperatures were studied.The microstructure consisted of polygonal ferrite and precipitates when the steel was coiled at 550℃,and when the steel was coiled between 460–520℃,the microstructure was composed of granular bainite and martensite and austenite(M/A)islands.The morphology of the crack was analyzed by scanning electron microscopy,and the in situ scanning electron microscope tensile test was used to find out the fracture mechanism and deformation behavior of the steel with different coiling temperatures.When the steel was coiled at 550℃,the cracks initiated at the ferrite grain boundary and propagated through the grains or along the grain boundaries.When the steel was coiled at 520℃,the cracks first initiated at the junction of ferrite and M/A island and then propagated through the grains.The steel coiled at 520℃ has quite good mechanical properties and relatively high hole expansion ratio.
文摘Mice deficient in the transcription factor pleomorphic adenoma gene 1(PLAG1)exhibit reproductive issues that are characterized,in part,by decreased progressive sperm motility in the male.However,the underlying cause of this impairment is unknown.As epididymal transit is critical for sperm maturation and motility,the morphology of the epididymis of Plag1-deficient mice was investigated and the spatial expression patterns of PLAG1 protein and mRNA were identified.Using X-gal staining and in situ hybridization,PLAG1 was shown to be widely expressed in both the epithelium and stroma in all regions of the mouse epididymis.Interestingly,the X-gal staining pattern was markedly different in the cauda,where it could be suggestive of PLAG1 secretion into the epididymal lumen.At all ages investigated,the morphology of epididymides from Plag1 knockout(KO)mice was aberrant;the tubule failed to elongate and coil,particularly in the corpus and cauda,and the cauda was malformed,lacking its usual bulbous shape.Moreover,the epididymides from Plag1 KO mice were significantly reduced in size relative to body weight.In 20%of Plag1-deficient mice,the left testicle and epididymis were lacking.The impaired morphogenesis of the epididymal tubule is likely to be a major contributing factor to the fertility problems observed in male Plag1-deficient mice.These results also establish PLAG1 as an important regulator of male reproduction,not only through its involvement in testicular sperm production,but also via its role in the development and function of the epididymis.
基金supported by Science and Technology Innovation Cooperation Project between China and South Africa(2017YFE0113400).
文摘The strength-to-weight ratio is an important property of high-strength low-alloy(HSLA)steel in pipeline,whose precipitation strengthening can be improved.The final rolling temperature(FRT)and coiling temperature(CT)are the key process parameters in the control of precipitates and microstructure.Continuous cooling rate was fixed at 10℃/s,and the effects of deformation and coiling temperatures on precipitates and microstructure of Ti-Nb microalloyed HSLA steel were investigated through thermo-mechanical controlled processing on Gleeble 3500.The microstructure is mainly acicular ferrite with high density dislocation and several microns scale.The size and volume fraction of the precipitates were studied under transmission electron microscopy.The results showed that the diameter of the precipitates was in the range between 4 and 240 nm.The optimized combination of parameters is FRT of 820℃and CT of 550℃,and the volume fraction of precipitates obtained under this process is 0.59%.
基金supported by grant of Changzhou science and technology projects of social development (No. CS2007203)
文摘Prompt diagnosis and therapy of aneurysms are critical for patients with nontraumatic subarachnoid hemorrhage （SAH）.The aim of our study was to assess the clinical usefulness of multislice computed tomography angiography （CTA） in the surgical and endovascular treatment of intracranial aneurysms.A total of 195 cases with 206 intracranial aneurysms underwent CTA.Fifty （24%） aneurysms underwent surgical clipping while 156 （76%） aneurysms underwent endovascular coiling.In the five missed aneurysms at digital substraction angiography and the nine aneurysms with mass intracerebral hematomas,surgical treatment was successfully performed based on 16-slice CTA alone,and the other 36 aneurysms were clipped on the main basis of the CTA.The intraoperative findings correlated well with the CTA findings and all aneurysms were clipped successfully.Sixteen-slice CTA image information has been shown to determine the choice of aneurysm therapy and assist the surgical and endovascular treatment of intracranial aneurysms.
基金supported by grants from the National Natural Science Foundation of China,grant no. 81370041, 81771233, 81671655the Outstanding Clinical Discipline Project of Shanghai Pudonggrant no.PWYgy2018-04.
文摘Background:To evaluate the efficacy of stent-assisted coiling(SAC)for the treatment of carotid ophthalmic segment aneurysm segment aneurysms(OSAs)of the internal carotid artery(ICA)through detailed long-term follow-up of a large patient cohort.Methods:We retrospectively analyzed 88 consecutive patients with OSAs between January 2009 and January 2020 at our center.Angiographic results were evaluated using the modified Raymond grading system and clinical outcomes were evaluated using the mRS scale.The primary endpoints were major aneurysm recurrence and poor clinical outcomes for at least 18 months of follow-up.The patients were asked to attend clinical follow-up assessments and possibly undergo DSA or MR via telephone.Results:We enrolled 88 patients with 99 OSAs treated with coiling,of whom 76 were treated with SAC.The coiling procedures were successful in all 88 patients.Overall,complications occurred in 8 patients(9.1%).No procedure-related mortality was observed.67(76.1%)experienced immediate aneurysm occlusion at the end of the procedure.Long-term angiographic follow-up(18 months)was available in 45/88 aneurysms(51%)(average 18.7±5.2 months).Four patients continued their follow-up for 5 years after initial aneurysm treatment.After a clinical follow-up time of 28.7 months(range,12-51 months),85 patients(95.5%)achieved favorable clinical outcomes(mRS scores of 0-2).Conclusions:This study indicates that SAC treatment is a safe and effective therapeutic alternative for ruptured and unruptured OSAs.The procedural risks are low with relatively long-term effectiveness.
基金This work was financially supported by the Joint Fund of Iron and Steel Research(No.U1660103)National Natural Science Foundation of China(No.51574162)+2 种基金the National Key R&D Program of China(No.2018YFE0306102)3DAP measurements were made in the Instrumental Analysis and Research Center at Shanghai UniversityThe authors would like to express sincere thanks for their support.
文摘Low-carbon steel is widely used for household appliance and automotive panel steel because of its excellent plasticity.Unfortunately,yield point phenomena easily appear in the low-carbon steel produced by a continuous annealing process and cause degradation to the surface quality during processing.The effect of the coiling temperature(600-750℃)and annealing temperature(740-820℃)on the yield point behavior is studied.Tensile tests show that coiling temperature has a greater effect on yield point elongation(YPE)and aging index(AI)than the annealing temperature.Microstructure observations show that coiling temperature at 750℃would make the micron-sized carbides appearing at the grain boundary disappear and a number of dispersed nanoscale carbides precipitate in grain interior,corresponding to the highest solid solution carbon content in the matrix of 750℃coiled sample.The experimental results suggest that AI rather than YPE has a positive relationship with the solid solution carbon content of the low-carbon steel.And YPE has a positive relationship with the upper/lower yield strength.
基金Funded by the National Natural Science Foundation of China(No.51501056)Natural Science Foundation of Hebei Province(No.E2016209341)+2 种基金Educational Commission of Hebei Province(No.BJ2014031)Project of Science and Technology of Tangshan(Nos.14130243B and 15130202C)Foundation of North China University of Science and Technology(No.JP201510)
文摘The effects of hot-strip coiling temperature on Ti（C,N） precipitation, texture and hydrogen permeation behavior in DC06 EK enamel steel were investigated by TEM, EBSD test and electrochemical hydrogen permeation experiment. It was found that the Ti（C,N） particles in hot-strip coarsened with increasing coiling temperature, whereas after cold-rolling and annealing, the size difference of Ti（C,N） particles was lessened. The hot-strip coiling temperature has a significant impact on the recrystallized texture in the subsequent cold-rolled and annealed sheet. Hot-strip using high temperature（700 ℃） coiling leads to strong {111} recrystallized texture in annealed sheet, with peak intensity 9.2. On the contrary, in annealed sheets using hot-strip coiling at 650 ℃, their {111} recrystallized textures were weaker, which was also reflected in their rmvalues. Even though the hydrogen diffusion coefficient is slightly lower（7.76×10^（-5） mm^2/s） in annealed sheet using low temperature coiling（600 ℃）, appropriately higher coiling temperature is more suitable for DC06 EK enamel steel combining both good drawability and fish-scale resistance.
文摘Objective:This study aimed to evaluate the clinical and angiographic outcomes of aneurysms that were completely or near-completely embolized and ascertain whether complete embolization is important in the stent-assisted coiling(SAC)of intracranial aneurysms.Methods:This retrospective study enrolled 390 patients(417 aneurysms).Among them,complete(100%)or nearcomplete(>90%)angiographic obliteration of the aneurysms on immediate angiography was accomplished.Baseline characteristics,complications,angiography follow-up results,and clinical outcomes were analyzed.Results:Cumulative adverse events occurred in 30 patients(7.7%),including thromboembolic complications in 17(4.4%),intraoperative rupture in 10(2.6%),and others in 3(0.8%).Statistical analyses revealed an increased intraprocedural rupture rate in the initial completely occluded aneurysms(5.6%compared with 1.0%).The incidence of cumulative adverse events was higher in patients with completely occluded aneurysms(11.1%)than in those with near-completely occluded aneurysms(5.5%).Angiography follow-up was available for 173 aneurysms.Aneurysm occlusion status at follow-up was correlated with stent placement(p?0.000,odds ratio?5.847),size(p?0.000,odds ratio?6.446 for tiny aneurysms;and p?0.001,odds ratio?5.616 for small aneurysms),and initial aneurysm occlusion status(p?0.001,odds ratio?3.436).Complete occlusion at followup was seen in 82.6%of the initial complete occlusion group versus 63.0%of the initial near-complete occlusion group.The incidence of complete occlusion at follow-up was higher in the initial completely occluded aneurysms with SAC(100%)than in the initial completely occluded aneurysms with non-SAC(65.2%).Conclusions:Initial complete treatment may lead to higher complication rates and good clinical outcomes at follow-up.Stent placement may enhance progressive aneurysm occlusion.Initial complete occlusion with SAC can provide durable closure at follow-up.
基金National Natural Science Foundation of China for financial support, under Grant No. 50104004.
文摘The effect of coiling temperatures on the evolution of texture in Ti-IF steel during ferritic hot rolling, cold rolling and annealing was studied. It was found that texture evolution at high temperature coiling is absolutely different from that at low temperature one. The hot band texture includes a strong α-fiber as well as a weak γ-fiber after ferritic hot rolling and low temperature coiling. Both of them intensify after cold rolling and a γ-fiber with peak at {111}〈112〉 is the main texture of annealed samples. However, the main component of the hot band texture after high temperature coiling is v-fiber. After cold rolling, the intensity of γ texture reduces; α fiber （except {111}〈110〉 component） intensifies and a strong and well-proportioned γ-fiber forms in the annealed samples.
文摘The effects of cooling rate and coiling temperature on microstructure and mechanical properties of a plain carbon steel were investigated by combining metallography and tensile experiments. The results indicate that ferrite grain size is refined and bainite transformation occurs to ensure high strength and elongation, as the cooling rate is quick enough. Yield strength and tensite strength improve with the decreased finish cooling temperature, but the elongation decreases too significantly to meet the requirements. Thus, the cooling rate must be quick enough, and the appropriate coiling temperature should be carefully selected to obtain refined ferrite and a small amount of bainite to improve the strength while the plasticity is also ensured. Under this condition, the Mn element concentration can be reduced to save cost or produce higher strength steel with same chemical composition.
文摘A new intelligent control scheme for hot strip coiling temperature is presented. In this scheme, the prediction mode1 of finishing temperature and the presetting model of main cooling zone are establish based on BP neural network, the feed-forward open-loop control model of main cooling zone is constructed based on T-S fuzzy neural network, a new improved structure of T-S fuzzy neural network is developed, and the feedback close-loop control model of precision cooling zone is obtained based on fuzzy control. The effectiveness of the proposed scheme has been demonstrated by computer simulation with a satisfactory result.
基金The authors greatly appreciate the financial support of the National Natural Science Foundation of China(11502155)Natural Science Foundation of Shanxi Province(201901D211112)the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi(2019L0328).We thank Prof.Yuren Wang and Mrs.Tingt-ing Zhao for discussions.
文摘It is of great significance to study the water absorption and expansion of cells,which are essential for the growth and life regulation of plants,not only for understanding the complex life phenomena of plants,but also for the manufacture of biomimetic materials.The main purpose of this study is to shed light on the mechanism of a novel coiling phenomenon of the split dandelion scape soaked in water and the high concentration mannitol solution.We discovered that the difference between water absorption/dehydration capacities of inner cells and lateral cells of the split dandelion scape generates asymmetric expansion/contraction between inner and lateral layers,resulting two opposite coiled patterns.Analogous to the deformable hypothesis of the thermal expansion model,the water absorption-induced cell expansion model was proposed to explain the coiling process of the split dandelion scape.Both the simulation and experimental results revealed that the coiling of dandelion scape is strongly depended on the response of cells to the stimulation of the solution environment.Showing considerable potential load bearing capacity of plants,the coiling phenomenon can be an inspiration to the designs of soft robots and bionic sensors for humidity control.
基金This work was supported by the National Natural Science Foundation of China(grant nos.31270281,32030071)to SQHNNSFC(32071671)to ZYT.
文摘The plant-pollinator‘arms race’model posits that a major driver of the evolution of elongated corollas in flowers is reciprocal selection for‘morphological fit’between pollinator-tongue length and access distance to nectar(usually corolla-tube length).Evidence for the pollinator-mediated selection on tube length and evolution of multiple,correlated floral traits remains inconclusive.To gain possible insights into the strength of stabilizing selection by assessing standing phenotypic variation,we measured a series of functionally important floral traits,including corolla tube length and‘effective’tube depth and degree of style coiling.We then calculated coefficients of variation(CV)for these traits in three field populations of R.schneideriana.Unlike in most long-tubed flowers,the bottom part of the corolla tube is completely occupied by the style,with no room for nectar.The length of this portion of the corolla tube was more variable(higher CV)than the upper part of the corolla tube,suggesting that functional tube depth was under stronger stabilizing selection.The degree of style coiling was negatively related to the corolla-tube length in all three populations of R.schneideriana,suggesting that there may be conflicting selection acting on style length and corolla-tube length,which are otherwise usually tightly correlated.Given the lack of nectar in the flowers of this species,the long corolla tubes and long styles may represent morphological holdovers from ancestors that were pollinated by long-tongued pollinators,as is still seen in related species in the western Himalayas.
文摘In this paper, the effect of hot-rolling processing parameters on the post-rolling transformation behavior of C-Mn-Cr-Cu weather-resistant martensitic steel was investigated.Results indicate that the post-rolling transformation behavior, particularly the post-coiling transformation behavior, strongly depends on the coiling temperature.Under a high coiling temperature, ferrite/pearlite transformation was mainly observed with a low trans-formation speed and transformation dilation after coiling.With decreasing coiling temperature, the proportion of bainite transformation increased with an increased transformation speed and transformation dilation.The dependence of transformation behavior on the coiling temperature could be one of the most important reasons behind the coil collapse of the experimental steel.The optimization of hot-rolling and coiling processing parameters of the steel strip, including laminar flow cooling, coiling temperature, and suspension time on the winding machine, can signi-ficantly reduce the transformation dilation of the steel after hot rolling, thus effectively controlling the coil collapse of the steel.
