In Comparison with the traditional point-by-point line generation method,the method we present is based on segment code in Pan-Euclidean geometric space and is quite different in re- spect of running speed and theoret...In Comparison with the traditional point-by-point line generation method,the method we present is based on segment code in Pan-Euclidean geometric space and is quite different in re- spect of running speed and theoretical basis.This paper presents an approach of using segment code to draw straight lines and shows the characteristics of a digital line.It is a newly proposed al- gorithm applicable in CAD.展开更多
The use of pan-ethnic-group products form knowledge primarily depends on a designer＇s subjective experience without user participation. The majority of studies primarily focus on the detection of the perceptual deman...The use of pan-ethnic-group products form knowledge primarily depends on a designer＇s subjective experience without user participation. The majority of studies primarily focus on the detection of the perceptual demands of consumers from the target product category. A pan-ethnic-group products form gene clustering method based on emotional semantic is constructed. Consumers＇ perceptual images of the pan-ethnic-group products are obtained by means of product form gene extraction and coding and computer aided product form clustering technology. A case of form gene clustering about the typical pan-ethnic-group products is investigated which indicates that the method is feasible. This paper opens up a new direction for the future development of product form design which improves the agility of product design process in the era of Industry 4.0.展开更多
目的泛癌分析长链非编码RNA(lncRNA)MIR22HG的表达及其与临床特征的关系。方法R语言分析癌症基因组图谱(TCGA)中MIR22HG在不同肿瘤组织中的表达及其与临床分期、淋巴结转移、肿瘤突变负荷(TMB)及微卫星不稳定(MSI)的关系;应用TIMER比较M...目的泛癌分析长链非编码RNA(lncRNA)MIR22HG的表达及其与临床特征的关系。方法R语言分析癌症基因组图谱(TCGA)中MIR22HG在不同肿瘤组织中的表达及其与临床分期、淋巴结转移、肿瘤突变负荷(TMB)及微卫星不稳定(MSI)的关系;应用TIMER比较MIR22HG表达与免疫浸润的关系;使用cBioPortal分析MIR22HG的突变频率及其与预后的关系;使用GDSC在线数据库分析MIR22HG与化疗药物敏感性的关系。利用GEO数据库肝癌数据集和12对肝癌标本验证MIR22HG在肝癌中的表达及其与索拉非尼治疗反应的关系;分析MIR22HG表达与索拉非尼治疗预后的关系;在肝癌细胞株HCC-LM3中过表达MIR22HG(NC组,MIR22HG过表达组),在肝癌细胞株MHCC-97H中敲除MIR22HG(NC组,sh-MIR22HG组),采用CCK-8检测肝癌细胞中MIR22HG对索拉非尼IC_(50)的影响。结果MIR22HG在大多数肿瘤中低表达(P<0.05),且多数肿瘤中MIR22HG基因存在缺失突变,其突变与肿瘤不良预后相关(P<0.05)。MIR22HG的表达水平与多种肿瘤的临床分期及淋巴结转移相关(P<0.05)。在多种肿瘤中MIR22HG的表达水平与TBM、MSI、免疫评分、免疫检查点相关基因表达及化疗药的药物敏感性显著相关(P<0.05)。6种常见免疫细胞中,中性粒细胞浸润水平与MIR22HG的表达水平相关性最强,尤其在乳腺癌、直肠癌及肾乳头状细胞癌中明显。多个数据集的分析结果验证MIR22HG在肝癌中低表达,且其低表达与肝癌进展相关(P<0.05)。MIR22HG低表达的患者经索拉非尼治疗后预后较好(HR=2.94,P=0.075),其低表达能有效预测肝癌患者索拉非尼治疗效果(AUC=0.8095)。过表达MIR22HG能降低肝癌细胞对索拉非尼的敏感性(IC_(50 NC) vs IC_(50 MIR22HG)=7.731 vs 15.61);而敲除MIR22HG的表达则能增加肝癌细胞对索拉非尼的敏感性(IC_(50 NC) vs IC50sh-MIR22HG=7.986 vs 5.085)。结论MIR22HG的表达与多种肿瘤的分期、有否淋巴结转移、肿瘤突变负荷、微卫星不稳定、免疫细胞浸润及化疗药物敏感性相关。展开更多
三维(Three-dimension,3D)多媒体技术,尤其是和3D视频相比有所差距的3D音频技术受到了广泛的关注。当前三维音频技术研究可分为基于物理声场重建的多声道音频技术和基于感知的声音场景重建的多声道音频技术两大类。物理声场重建技术的...三维(Three-dimension,3D)多媒体技术,尤其是和3D视频相比有所差距的3D音频技术受到了广泛的关注。当前三维音频技术研究可分为基于物理声场重建的多声道音频技术和基于感知的声音场景重建的多声道音频技术两大类。物理声场重建技术的重要代表是基于球谐分解的声重放技术和波场合成技术(Wave field synthesis,WFS),基于感知的声音场景重建技术主要包括幅度平移技术(Amplitude panning,AP)和基于头相关传输函数的双耳重建技术(Head related transfer function,HRTF)。本文对上述4类三维音频技术及其对应的典型系统进行了介绍及对比分析,并对三维音频技术当前3大主要研究热点:空间听觉机制、三维音频压缩编码以及三维音频系统精简的现状与前沿技术进行了介绍。展开更多
The Pan Pearl River Delta （PPRD） Regional Co-operation Framework Agreement was signed in 2004. It aims to bring prosperity through partnership among nine Chinese Mainland provinces and China ＂s two special administ...The Pan Pearl River Delta （PPRD） Regional Co-operation Framework Agreement was signed in 2004. It aims to bring prosperity through partnership among nine Chinese Mainland provinces and China ＂s two special administrative regions. In this paper, we use a dynamic panel data model to examine the economic growth of the PPRD economies from 1985 to 2009. Our analysis confirms the existence of regional growth spillover effects in the PPRD area. Our results also show that economic growth spillover effects of non-PPRD regions on the PPRD regions are greater than those among the PPRD members themselves. These findings imply that economic integration between Chinese provinces has generated considerable spillover effects on regional growth. However, the anticipated benefits of the implementation of the PPRD agreement have not been realized thus far. Therefore, greater effort shouM be made to promote further economic integration among these members so that their local economies can benefit from the positive spillover effects.展开更多
文摘In Comparison with the traditional point-by-point line generation method,the method we present is based on segment code in Pan-Euclidean geometric space and is quite different in re- spect of running speed and theoretical basis.This paper presents an approach of using segment code to draw straight lines and shows the characteristics of a digital line.It is a newly proposed al- gorithm applicable in CAD.
基金Supported by National Key Technology R&D Program,China(Grant No.2015BAH21F01)National 111 Project,China(Grant No.B13044)
文摘The use of pan-ethnic-group products form knowledge primarily depends on a designer＇s subjective experience without user participation. The majority of studies primarily focus on the detection of the perceptual demands of consumers from the target product category. A pan-ethnic-group products form gene clustering method based on emotional semantic is constructed. Consumers＇ perceptual images of the pan-ethnic-group products are obtained by means of product form gene extraction and coding and computer aided product form clustering technology. A case of form gene clustering about the typical pan-ethnic-group products is investigated which indicates that the method is feasible. This paper opens up a new direction for the future development of product form design which improves the agility of product design process in the era of Industry 4.0.
文摘目的泛癌分析长链非编码RNA(lncRNA)MIR22HG的表达及其与临床特征的关系。方法R语言分析癌症基因组图谱(TCGA)中MIR22HG在不同肿瘤组织中的表达及其与临床分期、淋巴结转移、肿瘤突变负荷(TMB)及微卫星不稳定(MSI)的关系;应用TIMER比较MIR22HG表达与免疫浸润的关系;使用cBioPortal分析MIR22HG的突变频率及其与预后的关系;使用GDSC在线数据库分析MIR22HG与化疗药物敏感性的关系。利用GEO数据库肝癌数据集和12对肝癌标本验证MIR22HG在肝癌中的表达及其与索拉非尼治疗反应的关系;分析MIR22HG表达与索拉非尼治疗预后的关系;在肝癌细胞株HCC-LM3中过表达MIR22HG(NC组,MIR22HG过表达组),在肝癌细胞株MHCC-97H中敲除MIR22HG(NC组,sh-MIR22HG组),采用CCK-8检测肝癌细胞中MIR22HG对索拉非尼IC_(50)的影响。结果MIR22HG在大多数肿瘤中低表达(P<0.05),且多数肿瘤中MIR22HG基因存在缺失突变,其突变与肿瘤不良预后相关(P<0.05)。MIR22HG的表达水平与多种肿瘤的临床分期及淋巴结转移相关(P<0.05)。在多种肿瘤中MIR22HG的表达水平与TBM、MSI、免疫评分、免疫检查点相关基因表达及化疗药的药物敏感性显著相关(P<0.05)。6种常见免疫细胞中,中性粒细胞浸润水平与MIR22HG的表达水平相关性最强,尤其在乳腺癌、直肠癌及肾乳头状细胞癌中明显。多个数据集的分析结果验证MIR22HG在肝癌中低表达,且其低表达与肝癌进展相关(P<0.05)。MIR22HG低表达的患者经索拉非尼治疗后预后较好(HR=2.94,P=0.075),其低表达能有效预测肝癌患者索拉非尼治疗效果(AUC=0.8095)。过表达MIR22HG能降低肝癌细胞对索拉非尼的敏感性(IC_(50 NC) vs IC_(50 MIR22HG)=7.731 vs 15.61);而敲除MIR22HG的表达则能增加肝癌细胞对索拉非尼的敏感性(IC_(50 NC) vs IC50sh-MIR22HG=7.986 vs 5.085)。结论MIR22HG的表达与多种肿瘤的分期、有否淋巴结转移、肿瘤突变负荷、微卫星不稳定、免疫细胞浸润及化疗药物敏感性相关。
文摘三维(Three-dimension,3D)多媒体技术,尤其是和3D视频相比有所差距的3D音频技术受到了广泛的关注。当前三维音频技术研究可分为基于物理声场重建的多声道音频技术和基于感知的声音场景重建的多声道音频技术两大类。物理声场重建技术的重要代表是基于球谐分解的声重放技术和波场合成技术(Wave field synthesis,WFS),基于感知的声音场景重建技术主要包括幅度平移技术(Amplitude panning,AP)和基于头相关传输函数的双耳重建技术(Head related transfer function,HRTF)。本文对上述4类三维音频技术及其对应的典型系统进行了介绍及对比分析,并对三维音频技术当前3大主要研究热点:空间听觉机制、三维音频压缩编码以及三维音频系统精简的现状与前沿技术进行了介绍。
基金Financial support from the University of Macao(RG017/06- 07S/CY/FSH and RG041/09-10S/CY/FSH)the Australian Research Council(DP1092913)
文摘The Pan Pearl River Delta （PPRD） Regional Co-operation Framework Agreement was signed in 2004. It aims to bring prosperity through partnership among nine Chinese Mainland provinces and China ＂s two special administrative regions. In this paper, we use a dynamic panel data model to examine the economic growth of the PPRD economies from 1985 to 2009. Our analysis confirms the existence of regional growth spillover effects in the PPRD area. Our results also show that economic growth spillover effects of non-PPRD regions on the PPRD regions are greater than those among the PPRD members themselves. These findings imply that economic integration between Chinese provinces has generated considerable spillover effects on regional growth. However, the anticipated benefits of the implementation of the PPRD agreement have not been realized thus far. Therefore, greater effort shouM be made to promote further economic integration among these members so that their local economies can benefit from the positive spillover effects.
