In real environment, it is unlikely that contaminants exist singly; environmental contamination with chemical mixtures is a norm. However, the impacts of chemical mixtures on environmental quality and ecosystem health...In real environment, it is unlikely that contaminants exist singly; environmental contamination with chemical mixtures is a norm. However, the impacts of chemical mixtures on environmental quality and ecosystem health have been overlooked in the past.Among the complex interactions between different contaminants, their relationship with the rise of antibiotic resistance（AR） is an emerging environmental concern. In this paper,we review recent progresses on how chemicals or chemical mixtures promote AR. We propose that, through co-selection, agents causing stress to bacteria may induce AR. The mechanisms for chemical mixtures to promote AR are also discussed. We also propose that,mechanistic understanding of co-selection of chemical mixtures for AR should be a future research priority in environmental health research.展开更多
Metals are increasingly important risk factors for the evolution of antibiotic resistance in environments.The rapid development of antibiotic resistance is occurring at a global scale.We therefore stride into the post...Metals are increasingly important risk factors for the evolution of antibiotic resistance in environments.The rapid development of antibiotic resistance is occurring at a global scale.We therefore stride into the post-antibiotic era and have to battle antibiotic resistance in the Anthropocene.Metals are widely used and their pollution is widespread worldwide.More importantly,metal-induced co-selection greatly expands the environmental resistomes and increases the health risk of antibiotic resistance in environments.Here,we reviewed the metal-induced co-selection and their increasingly important roles in the development of antibiotic resistance.In particular,we highlight the metal-rich environments that maintain reservoirs for high-risk antibiotic resistance genes with horizontally transferable potentials.We also call for considerations and further investigations of other co-selective agents and the efficacy of metal-based interventions to better manage and combat the global antibiotic resistance crisis within the One Health framework.展开更多
基金supported by the National Key Research and Development Plan(No.2016YFD0800205)the National Natural Science Foundation of China(Nos.41571130063 and31770127)the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB15020402)
文摘In real environment, it is unlikely that contaminants exist singly; environmental contamination with chemical mixtures is a norm. However, the impacts of chemical mixtures on environmental quality and ecosystem health have been overlooked in the past.Among the complex interactions between different contaminants, their relationship with the rise of antibiotic resistance（AR） is an emerging environmental concern. In this paper,we review recent progresses on how chemicals or chemical mixtures promote AR. We propose that, through co-selection, agents causing stress to bacteria may induce AR. The mechanisms for chemical mixtures to promote AR are also discussed. We also propose that,mechanistic understanding of co-selection of chemical mixtures for AR should be a future research priority in environmental health research.
基金supported by the National Natural Science Foundation of China(Grant Nos.41825017,42377392,and 42107407)the Fundamental Research Funds for the Central Universities(Grant No.265QZ2022006).
文摘Metals are increasingly important risk factors for the evolution of antibiotic resistance in environments.The rapid development of antibiotic resistance is occurring at a global scale.We therefore stride into the post-antibiotic era and have to battle antibiotic resistance in the Anthropocene.Metals are widely used and their pollution is widespread worldwide.More importantly,metal-induced co-selection greatly expands the environmental resistomes and increases the health risk of antibiotic resistance in environments.Here,we reviewed the metal-induced co-selection and their increasingly important roles in the development of antibiotic resistance.In particular,we highlight the metal-rich environments that maintain reservoirs for high-risk antibiotic resistance genes with horizontally transferable potentials.We also call for considerations and further investigations of other co-selective agents and the efficacy of metal-based interventions to better manage and combat the global antibiotic resistance crisis within the One Health framework.
