Ion channels,as membrane proteins,are the sensors of the cell.They act as the first line of communication with the world beyond the plasma membrane and transduce changes in the external and internal environments into ...Ion channels,as membrane proteins,are the sensors of the cell.They act as the first line of communication with the world beyond the plasma membrane and transduce changes in the external and internal environments into unique electrical signals to shape the responses of excitable cells.Because of their importance in cellular communication,ion channels have been intensively studied at the structural and functional levels.Here,we summarize the diverse approaches,including molecular and cellular,chemical,optical,biophysical,and computational,used to probe the structural and functional rearrangements that occur during channel activation（or sensitization）,inactivation（or desensitization）,and various forms of modulation.The emerging insights into the structure and function of ion channels by multidisciplinary approaches allow the development of new pharmacotherapies as well as new tools useful in controlling cellular activity.展开更多
Secret key generation(SKG)is a promising solution to the problem of wireless communications security.As the first step of SKG,channel probing affects it significantly.Although there have been some probing schemes,ther...Secret key generation(SKG)is a promising solution to the problem of wireless communications security.As the first step of SKG,channel probing affects it significantly.Although there have been some probing schemes,there is a lack of research on the optimization of the probing process.This study investigates how to optimize correlated parameters to maximize the SKG rate(SKGR)in the time-division duplex(TDD)mode.First,we build a probing model which includes the effects of transmitting power,the probing period,and the dimension of sample vectors.Based on the model,the analytical expression of the SKGR is given.Next,we formulate an optimization problem for maximizing the SKGR and give an algorithm to solve it.We conclude the SKGR monotonically increases as the transmitting power increases.Relevant mathematical proofs are given in this study.From the simulation results,increasing appropriately the probing period and the dimension of the sample vector could increase the SKGR dramatically compared to a yardstick,which indicates the importance of optimizing the parameters related to the channel probing phase.展开更多
Ion channels are crucial in the generation and modulation of excitability in the nervous system and have been implicated in human epilepsy. Forty-one epilepsyassociated ion channel genes and their mutations are system...Ion channels are crucial in the generation and modulation of excitability in the nervous system and have been implicated in human epilepsy. Forty-one epilepsyassociated ion channel genes and their mutations are systematically reviewed. In this paper, we analyzed the genotypes, functional alterations（funotypes）, and phenotypes of these mutations. Eleven genes featured loss-offunction mutations and six had gain-of-function mutations.Nine genes displayed diversified funotypes, among which a distinct funotype-phenotype correlation was found in SCN1A. These data suggest that the funotype is an essential consideration in evaluating the pathogenicity of mutations and a distinct funotype or funotype-phenotype correlation helps to define the pathogenic potential of a gene.展开更多
Vascular smooth muscle cells（VSMCs） are the major component of vascular wall which are often stretched and compressed by pounding intravascular pressure.These mechanical signals are usually transformed to electrical...Vascular smooth muscle cells（VSMCs） are the major component of vascular wall which are often stretched and compressed by pounding intravascular pressure.These mechanical signals are usually transformed to electrical signals by the opening or closing of ion channels in VSNCs and endothelial cells.Intravascular pressure causes a graded membrane potential depolarization of the VSMCs and leads to vasoconstriction（i.e.,myogenic response）,independent of the vascular endothelium. Although the important role of cation channels including L-type Ca<sup>2+</sup> channels,K<sup>+</sup> channels,and TRP channels in the regulation of vascular tone has been well established the functional roles played by Cl<sup>-</sup> channels in the regulation of the membrane potential and vascular tone remain essentially obscure. Recent emerging evidence implicates very important roles of Cl<sup>-</sup> channels in vascular function ranging from the control of membrane potential equilibrium, vascular contraction and relaxation to the regulation of intracellular pH,cell volume homeostasis,cell proliferation,migration,and apoptosis.展开更多
We find that a conserved mutation residue Glu to residue Asp （E303D）, which both have the same polar and charged properties, makes Kit2.1 protein lose its function. To understand the mechanism, we identify three int...We find that a conserved mutation residue Glu to residue Asp （E303D）, which both have the same polar and charged properties, makes Kit2.1 protein lose its function. To understand the mechanism, we identify three interactions which control the conformation change and maintain the function of the Kit2.1 protein by combining homology modeling and molecular dynamics with targeted molecular dynamics. We find that the E303D mutation weakens these interactions and results in the loss of the related function. Our data indicate that not only the amino residues but also the interactions determine the function of proteins.展开更多
In this paper, we propose a new multi-user Rake receiver, based on the interference mutualization with a matrix representation for Multiple Input Single Output MISO channel. The proposed system used the Modified Gegen...In this paper, we propose a new multi-user Rake receiver, based on the interference mutualization with a matrix representation for Multiple Input Single Output MISO channel. The proposed system used the Modified Gegenbauer functions in order to generate the signal and to ensure the multi users transmission system. The new proposed receiver allows, using the temporal and special diversity, to avoid the interferences between symbols and to improve the system performances in terms of Bit Error Rate BER and interferences between users with a low algorithm complexity. The proposed solution is based on the classical Rake receiver associated with the equalizer receiver. In order to adapt the Rake approach, in single detection case and in multi users Ultra Wide Band environment, we propose a multi-user Rake receiver using the matrix form. Our proposed system is evaluated in terms of channel effects and multi users’ interferences.展开更多
This paper presents a performance study of the distributed coordination function （DCF） of 802.11 networks considering erroneous channel and capture effects under non-saturated traffic conditions employing a basic ac...This paper presents a performance study of the distributed coordination function （DCF） of 802.11 networks considering erroneous channel and capture effects under non-saturated traffic conditions employing a basic access method.The aggregate throughput of a practical wireless local area network （WLAN） strongly depends on the channel conditions.In a real radio environment,the received signal power at the access point from a station is subjected to deterministic path loss,shadowing,and fast multipath fading.The binary exponential backoff （BEB） mechanism of IEEE 802.11 DCF severely suffers from more channel idle time under high bit error rate （BER）.To alleviate the low performance of IEEE 802.11 DCF,a new mechanism is introduced,which greatly outperforms the existing methods under a high BER.A multidimensional Markov chain model is used to characterize the behavior of DCF in order to account both non-ideal channel conditions and capture effects.展开更多
基于图卷积神经网络(GCNN)的指静脉识别方法不仅可以解决传统指静脉识别方法识别率较低的问题,还可以解决其计算量大的问题。针对目前指静脉图模型结构不稳定和匹配效率因模型增大而下降的问题,采用SLIC(Simple Linear Iterative Cluste...基于图卷积神经网络(GCNN)的指静脉识别方法不仅可以解决传统指静脉识别方法识别率较低的问题,还可以解决其计算量大的问题。针对目前指静脉图模型结构不稳定和匹配效率因模型增大而下降的问题,采用SLIC(Simple Linear Iterative Clustering)超像素分割算法来构建加权图并改变GCNN提取加权图的图级特征。为了有效抓取图数据中的高阶特征并避免过平滑,建立一种双分支多交互的深度图卷积网络(GCN),旨在提升节点对高阶特征的掌握能力。首先根据节点特征对图结构进行调整;然后结合原始和重构后的图结构,构建了双分支网络架构以充分挖掘高阶特征;最后设计一种通道信息互动机制,以促进不同分支间的信息交流,从而提高特征的多样性。实验结果显示,在多个标准数据集上进行指静脉识别任务时,该网络能减少单张图片识别时间,提高识别效率,并有效减轻过平滑现象,相较于单分支的GCN,在识别精度上平均取得了超过1.5百分点的性能提升。展开更多
电信运营商拥有大规模的语音用户数,但是随着OTT(Over The Top)业务的广泛使用,给运营商基础语音业务受到了冲击,每用户通话时长(Minutes Of Usage,MOU)持续降低且收入逐年下降。5G增强通话是基于5G的新一代通话产品,提供超高清、智能...电信运营商拥有大规模的语音用户数,但是随着OTT(Over The Top)业务的广泛使用,给运营商基础语音业务受到了冲击,每用户通话时长(Minutes Of Usage,MOU)持续降低且收入逐年下降。5G增强通话是基于5G的新一代通话产品,提供超高清、智能化、全交互三大能力,以期增加用户黏性并为基础通话业务带来新的潜在增长空间。介绍5G增强通话的业务类型和发展现状,然后从建设原则、网络架构、数据通道信令功能(Data Channel Signaling Function,DCSF)网元建设方案、资源池建设方案、网络安全及可靠性等方面探讨5G增强通话控制面网元DCSF的建设实施方案。展开更多
In this paper, a free-space vortex channel model of the radio vortex system is proposed to describe the propagation characteristics of vortex signals over the vortex channel. The key idea is to combine the Laguerre-Ga...In this paper, a free-space vortex channel model of the radio vortex system is proposed to describe the propagation characteristics of vortex signals over the vortex channel. The key idea is to combine the Laguerre-Gaussian(LG) modes in the optical field with the free-space propagation model in the radio field. The proposed free-space vortex channel model is derived from the electric field expression of the LG modes and the freespace channel transfer function of the freespace propagation model theoretically. Simulation results verify that the proposed model could reflect the vortex channel characteristics better than the currently used free-space propagation model.展开更多
Hyperpolarization-activated and cyclic nucleotide-gated(HCN) channels,distributing in a variety of tissues,especially in excitable cells such as heart cells and many kinds of neurons,have an important role in the modu...Hyperpolarization-activated and cyclic nucleotide-gated(HCN) channels,distributing in a variety of tissues,especially in excitable cells such as heart cells and many kinds of neurons,have an important role in the modulation of heart rate and neuronal excitability.Different from typical voltage-gated sodium channels and potassium channels,HCN channels were evoked inward currents when the cell was hyperpolarized.More and more recent studies have disclosed that HCN channels play important roles in the nervous system,which were linked with its special electrophysiological features as well as its regulatory effect on the cellular membrane excitability.HCN channels could be modulated by many factors including both extracellular molecules and intracellular signaling cascades,which made its functions complicated in the different condition.Based on its role,HCN channels are presumed to be a promising target for chronic pain and brain disorders.In this paper,we will focus on the advancement of roles of HCN channels in the neural system as well as its complex modulator factors.展开更多
基金supported by grants from the National Natural Science Foundation of China(91132303,30830035)the National Basic Research Development Program of China (2011CBA00408)the China Postdoctoral Science Foundation(2012M511105)
文摘Ion channels,as membrane proteins,are the sensors of the cell.They act as the first line of communication with the world beyond the plasma membrane and transduce changes in the external and internal environments into unique electrical signals to shape the responses of excitable cells.Because of their importance in cellular communication,ion channels have been intensively studied at the structural and functional levels.Here,we summarize the diverse approaches,including molecular and cellular,chemical,optical,biophysical,and computational,used to probe the structural and functional rearrangements that occur during channel activation（or sensitization）,inactivation（or desensitization）,and various forms of modulation.The emerging insights into the structure and function of ion channels by multidisciplinary approaches allow the development of new pharmacotherapies as well as new tools useful in controlling cellular activity.
基金supported in part by the national natural science foundation of China (NSFC) under Grant61871193in part by the R&D Program of key science and technology fields in Guangdong province under Grant 2019B090912001in part by the Guangzhou Key Field R&D Program under Grant 202206030005
文摘Secret key generation(SKG)is a promising solution to the problem of wireless communications security.As the first step of SKG,channel probing affects it significantly.Although there have been some probing schemes,there is a lack of research on the optimization of the probing process.This study investigates how to optimize correlated parameters to maximize the SKG rate(SKGR)in the time-division duplex(TDD)mode.First,we build a probing model which includes the effects of transmitting power,the probing period,and the dimension of sample vectors.Based on the model,the analytical expression of the SKGR is given.Next,we formulate an optimization problem for maximizing the SKGR and give an algorithm to solve it.We conclude the SKGR monotonically increases as the transmitting power increases.Relevant mathematical proofs are given in this study.From the simulation results,increasing appropriately the probing period and the dimension of the sample vector could increase the SKGR dramatically compared to a yardstick,which indicates the importance of optimizing the parameters related to the channel probing phase.
基金supported by the National Natural Science Foundation of China (81571273,81571274,81501124,81271434,and 81301107)Omics-based precision medicine of epilepsy being entrusted by Key Research Project of the Ministry of Science and Technology of China (2016YFC0904400)+5 种基金the Natural Science Foundation of Guangdong Province,China (2014A030313489)Science and Technology Planning Projects of Guangdong Province,China (2012B031800404 and 2013B051000084)the Department of Education of Guangdong Province,China (2013CXZDA022,2013KJCX0156,and 2012KJCX009)the Foundation for High-level Talents in Higher Education of Guangdong Province,China (2013-167)Yangcheng Scholar Research Projects of Guangzhou Municipal College (12A016S and 12A017G)Science and Technology Projects of Guangzhou,Guangdong Province,China (2014J4100069,201508020011,201604020161,and 201607010002)
文摘Ion channels are crucial in the generation and modulation of excitability in the nervous system and have been implicated in human epilepsy. Forty-one epilepsyassociated ion channel genes and their mutations are systematically reviewed. In this paper, we analyzed the genotypes, functional alterations（funotypes）, and phenotypes of these mutations. Eleven genes featured loss-offunction mutations and six had gain-of-function mutations.Nine genes displayed diversified funotypes, among which a distinct funotype-phenotype correlation was found in SCN1A. These data suggest that the funotype is an essential consideration in evaluating the pathogenicity of mutations and a distinct funotype or funotype-phenotype correlation helps to define the pathogenic potential of a gene.
文摘Vascular smooth muscle cells（VSMCs） are the major component of vascular wall which are often stretched and compressed by pounding intravascular pressure.These mechanical signals are usually transformed to electrical signals by the opening or closing of ion channels in VSNCs and endothelial cells.Intravascular pressure causes a graded membrane potential depolarization of the VSMCs and leads to vasoconstriction（i.e.,myogenic response）,independent of the vascular endothelium. Although the important role of cation channels including L-type Ca<sup>2+</sup> channels,K<sup>+</sup> channels,and TRP channels in the regulation of vascular tone has been well established the functional roles played by Cl<sup>-</sup> channels in the regulation of the membrane potential and vascular tone remain essentially obscure. Recent emerging evidence implicates very important roles of Cl<sup>-</sup> channels in vascular function ranging from the control of membrane potential equilibrium, vascular contraction and relaxation to the regulation of intracellular pH,cell volume homeostasis,cell proliferation,migration,and apoptosis.
基金Supported by the National Natural Science Foundation of China under Grant Nos 11247010,11175055,11475053 and 11347017the Natural Science Foundation of Hebei Province under Grant Nos C2012202079 and C201400305
文摘We find that a conserved mutation residue Glu to residue Asp （E303D）, which both have the same polar and charged properties, makes Kit2.1 protein lose its function. To understand the mechanism, we identify three interactions which control the conformation change and maintain the function of the Kit2.1 protein by combining homology modeling and molecular dynamics with targeted molecular dynamics. We find that the E303D mutation weakens these interactions and results in the loss of the related function. Our data indicate that not only the amino residues but also the interactions determine the function of proteins.
文摘In this paper, we propose a new multi-user Rake receiver, based on the interference mutualization with a matrix representation for Multiple Input Single Output MISO channel. The proposed system used the Modified Gegenbauer functions in order to generate the signal and to ensure the multi users transmission system. The new proposed receiver allows, using the temporal and special diversity, to avoid the interferences between symbols and to improve the system performances in terms of Bit Error Rate BER and interferences between users with a low algorithm complexity. The proposed solution is based on the classical Rake receiver associated with the equalizer receiver. In order to adapt the Rake approach, in single detection case and in multi users Ultra Wide Band environment, we propose a multi-user Rake receiver using the matrix form. Our proposed system is evaluated in terms of channel effects and multi users’ interferences.
文摘This paper presents a performance study of the distributed coordination function （DCF） of 802.11 networks considering erroneous channel and capture effects under non-saturated traffic conditions employing a basic access method.The aggregate throughput of a practical wireless local area network （WLAN） strongly depends on the channel conditions.In a real radio environment,the received signal power at the access point from a station is subjected to deterministic path loss,shadowing,and fast multipath fading.The binary exponential backoff （BEB） mechanism of IEEE 802.11 DCF severely suffers from more channel idle time under high bit error rate （BER）.To alleviate the low performance of IEEE 802.11 DCF,a new mechanism is introduced,which greatly outperforms the existing methods under a high BER.A multidimensional Markov chain model is used to characterize the behavior of DCF in order to account both non-ideal channel conditions and capture effects.
文摘基于图卷积神经网络(GCNN)的指静脉识别方法不仅可以解决传统指静脉识别方法识别率较低的问题,还可以解决其计算量大的问题。针对目前指静脉图模型结构不稳定和匹配效率因模型增大而下降的问题,采用SLIC(Simple Linear Iterative Clustering)超像素分割算法来构建加权图并改变GCNN提取加权图的图级特征。为了有效抓取图数据中的高阶特征并避免过平滑,建立一种双分支多交互的深度图卷积网络(GCN),旨在提升节点对高阶特征的掌握能力。首先根据节点特征对图结构进行调整;然后结合原始和重构后的图结构,构建了双分支网络架构以充分挖掘高阶特征;最后设计一种通道信息互动机制,以促进不同分支间的信息交流,从而提高特征的多样性。实验结果显示,在多个标准数据集上进行指静脉识别任务时,该网络能减少单张图片识别时间,提高识别效率,并有效减轻过平滑现象,相较于单分支的GCN,在识别精度上平均取得了超过1.5百分点的性能提升。
文摘电信运营商拥有大规模的语音用户数,但是随着OTT(Over The Top)业务的广泛使用,给运营商基础语音业务受到了冲击,每用户通话时长(Minutes Of Usage,MOU)持续降低且收入逐年下降。5G增强通话是基于5G的新一代通话产品,提供超高清、智能化、全交互三大能力,以期增加用户黏性并为基础通话业务带来新的潜在增长空间。介绍5G增强通话的业务类型和发展现状,然后从建设原则、网络架构、数据通道信令功能(Data Channel Signaling Function,DCSF)网元建设方案、资源池建设方案、网络安全及可靠性等方面探讨5G增强通话控制面网元DCSF的建设实施方案。
基金supported in part by National Science Foundation for Distinguished Young Scholars of China with Grant number 61325004Major Program of National Natural Science Foundation of Hubei in China with Grant number 2016CFA009+2 种基金the Fundamental Research Funds for the Central Universities with Grant number 2015ZDTD012the National Natural Science Foundation of China under Grant No.61463035the Research Foundation of the Education Department of Jiangxi Province under Grant No.GJJ150198
文摘In this paper, a free-space vortex channel model of the radio vortex system is proposed to describe the propagation characteristics of vortex signals over the vortex channel. The key idea is to combine the Laguerre-Gaussian(LG) modes in the optical field with the free-space propagation model in the radio field. The proposed free-space vortex channel model is derived from the electric field expression of the LG modes and the freespace channel transfer function of the freespace propagation model theoretically. Simulation results verify that the proposed model could reflect the vortex channel characteristics better than the currently used free-space propagation model.
基金supported by the Beijing Municipal Natural Science Foundation(7142123)
文摘Hyperpolarization-activated and cyclic nucleotide-gated(HCN) channels,distributing in a variety of tissues,especially in excitable cells such as heart cells and many kinds of neurons,have an important role in the modulation of heart rate and neuronal excitability.Different from typical voltage-gated sodium channels and potassium channels,HCN channels were evoked inward currents when the cell was hyperpolarized.More and more recent studies have disclosed that HCN channels play important roles in the nervous system,which were linked with its special electrophysiological features as well as its regulatory effect on the cellular membrane excitability.HCN channels could be modulated by many factors including both extracellular molecules and intracellular signaling cascades,which made its functions complicated in the different condition.Based on its role,HCN channels are presumed to be a promising target for chronic pain and brain disorders.In this paper,we will focus on the advancement of roles of HCN channels in the neural system as well as its complex modulator factors.
