Ion channels,as membrane proteins,are the sensors of the cell.They act as the first line of communication with the world beyond the plasma membrane and transduce changes in the external and internal environments into ...Ion channels,as membrane proteins,are the sensors of the cell.They act as the first line of communication with the world beyond the plasma membrane and transduce changes in the external and internal environments into unique electrical signals to shape the responses of excitable cells.Because of their importance in cellular communication,ion channels have been intensively studied at the structural and functional levels.Here,we summarize the diverse approaches,including molecular and cellular,chemical,optical,biophysical,and computational,used to probe the structural and functional rearrangements that occur during channel activation（or sensitization）,inactivation（or desensitization）,and various forms of modulation.The emerging insights into the structure and function of ion channels by multidisciplinary approaches allow the development of new pharmacotherapies as well as new tools useful in controlling cellular activity.展开更多
Secret key generation(SKG)is a promising solution to the problem of wireless communications security.As the first step of SKG,channel probing affects it significantly.Although there have been some probing schemes,ther...Secret key generation(SKG)is a promising solution to the problem of wireless communications security.As the first step of SKG,channel probing affects it significantly.Although there have been some probing schemes,there is a lack of research on the optimization of the probing process.This study investigates how to optimize correlated parameters to maximize the SKG rate(SKGR)in the time-division duplex(TDD)mode.First,we build a probing model which includes the effects of transmitting power,the probing period,and the dimension of sample vectors.Based on the model,the analytical expression of the SKGR is given.Next,we formulate an optimization problem for maximizing the SKGR and give an algorithm to solve it.We conclude the SKGR monotonically increases as the transmitting power increases.Relevant mathematical proofs are given in this study.From the simulation results,increasing appropriately the probing period and the dimension of the sample vector could increase the SKGR dramatically compared to a yardstick,which indicates the importance of optimizing the parameters related to the channel probing phase.展开更多
Ion channels are crucial in the generation and modulation of excitability in the nervous system and have been implicated in human epilepsy. Forty-one epilepsyassociated ion channel genes and their mutations are system...Ion channels are crucial in the generation and modulation of excitability in the nervous system and have been implicated in human epilepsy. Forty-one epilepsyassociated ion channel genes and their mutations are systematically reviewed. In this paper, we analyzed the genotypes, functional alterations（funotypes）, and phenotypes of these mutations. Eleven genes featured loss-offunction mutations and six had gain-of-function mutations.Nine genes displayed diversified funotypes, among which a distinct funotype-phenotype correlation was found in SCN1A. These data suggest that the funotype is an essential consideration in evaluating the pathogenicity of mutations and a distinct funotype or funotype-phenotype correlation helps to define the pathogenic potential of a gene.展开更多
Vascular smooth muscle cells（VSMCs） are the major component of vascular wall which are often stretched and compressed by pounding intravascular pressure.These mechanical signals are usually transformed to electrical...Vascular smooth muscle cells（VSMCs） are the major component of vascular wall which are often stretched and compressed by pounding intravascular pressure.These mechanical signals are usually transformed to electrical signals by the opening or closing of ion channels in VSNCs and endothelial cells.Intravascular pressure causes a graded membrane potential depolarization of the VSMCs and leads to vasoconstriction（i.e.,myogenic response）,independent of the vascular endothelium. Although the important role of cation channels including L-type Ca<sup>2+</sup> channels,K<sup>+</sup> channels,and TRP channels in the regulation of vascular tone has been well established the functional roles played by Cl<sup>-</sup> channels in the regulation of the membrane potential and vascular tone remain essentially obscure. Recent emerging evidence implicates very important roles of Cl<sup>-</sup> channels in vascular function ranging from the control of membrane potential equilibrium, vascular contraction and relaxation to the regulation of intracellular pH,cell volume homeostasis,cell proliferation,migration,and apoptosis.展开更多
We find that a conserved mutation residue Glu to residue Asp （E303D）, which both have the same polar and charged properties, makes Kit2.1 protein lose its function. To understand the mechanism, we identify three int...We find that a conserved mutation residue Glu to residue Asp （E303D）, which both have the same polar and charged properties, makes Kit2.1 protein lose its function. To understand the mechanism, we identify three interactions which control the conformation change and maintain the function of the Kit2.1 protein by combining homology modeling and molecular dynamics with targeted molecular dynamics. We find that the E303D mutation weakens these interactions and results in the loss of the related function. Our data indicate that not only the amino residues but also the interactions determine the function of proteins.展开更多
In this paper, we propose a new multi-user Rake receiver, based on the interference mutualization with a matrix representation for Multiple Input Single Output MISO channel. The proposed system used the Modified Gegen...In this paper, we propose a new multi-user Rake receiver, based on the interference mutualization with a matrix representation for Multiple Input Single Output MISO channel. The proposed system used the Modified Gegenbauer functions in order to generate the signal and to ensure the multi users transmission system. The new proposed receiver allows, using the temporal and special diversity, to avoid the interferences between symbols and to improve the system performances in terms of Bit Error Rate BER and interferences between users with a low algorithm complexity. The proposed solution is based on the classical Rake receiver associated with the equalizer receiver. In order to adapt the Rake approach, in single detection case and in multi users Ultra Wide Band environment, we propose a multi-user Rake receiver using the matrix form. Our proposed system is evaluated in terms of channel effects and multi users’ interferences.展开更多
This paper presents a performance study of the distributed coordination function （DCF） of 802.11 networks considering erroneous channel and capture effects under non-saturated traffic conditions employing a basic ac...This paper presents a performance study of the distributed coordination function （DCF） of 802.11 networks considering erroneous channel and capture effects under non-saturated traffic conditions employing a basic access method.The aggregate throughput of a practical wireless local area network （WLAN） strongly depends on the channel conditions.In a real radio environment,the received signal power at the access point from a station is subjected to deterministic path loss,shadowing,and fast multipath fading.The binary exponential backoff （BEB） mechanism of IEEE 802.11 DCF severely suffers from more channel idle time under high bit error rate （BER）.To alleviate the low performance of IEEE 802.11 DCF,a new mechanism is introduced,which greatly outperforms the existing methods under a high BER.A multidimensional Markov chain model is used to characterize the behavior of DCF in order to account both non-ideal channel conditions and capture effects.展开更多
In this paper, a free-space vortex channel model of the radio vortex system is proposed to describe the propagation characteristics of vortex signals over the vortex channel. The key idea is to combine the Laguerre-Ga...In this paper, a free-space vortex channel model of the radio vortex system is proposed to describe the propagation characteristics of vortex signals over the vortex channel. The key idea is to combine the Laguerre-Gaussian(LG) modes in the optical field with the free-space propagation model in the radio field. The proposed free-space vortex channel model is derived from the electric field expression of the LG modes and the freespace channel transfer function of the freespace propagation model theoretically. Simulation results verify that the proposed model could reflect the vortex channel characteristics better than the currently used free-space propagation model.展开更多
Hyperpolarization-activated and cyclic nucleotide-gated(HCN) channels,distributing in a variety of tissues,especially in excitable cells such as heart cells and many kinds of neurons,have an important role in the modu...Hyperpolarization-activated and cyclic nucleotide-gated(HCN) channels,distributing in a variety of tissues,especially in excitable cells such as heart cells and many kinds of neurons,have an important role in the modulation of heart rate and neuronal excitability.Different from typical voltage-gated sodium channels and potassium channels,HCN channels were evoked inward currents when the cell was hyperpolarized.More and more recent studies have disclosed that HCN channels play important roles in the nervous system,which were linked with its special electrophysiological features as well as its regulatory effect on the cellular membrane excitability.HCN channels could be modulated by many factors including both extracellular molecules and intracellular signaling cascades,which made its functions complicated in the different condition.Based on its role,HCN channels are presumed to be a promising target for chronic pain and brain disorders.In this paper,we will focus on the advancement of roles of HCN channels in the neural system as well as its complex modulator factors.展开更多
The nature of a wireless communication channel is very unpredictable. To design a good communication link, it is required to know the statistical model of the channel accurately. The average symbol error probability(A...The nature of a wireless communication channel is very unpredictable. To design a good communication link, it is required to know the statistical model of the channel accurately. The average symbol error probability(ASER) was analyzed for different modulation schemes. A unified analytical framework was presented to obtain closed-form solutions for calculating the ASER of M-ary differential phase-shift keying(M-DPSK), coherent M-ary phase-shift keying(M-PSK), and quadrature amplitude modulation(QAM) over single or multiple Nakagami-m fading channels. Moreover, the ASER was estimated and evaluated by using the maximal ratio-combining(MRC) diversity technique. Simulation results show that an error rate of the fading channel typically depends on Nakagami parameters(m), space diversity(N), and symbol rate(M). A comparison between M-PSK, M-DPSK, and M-QAM modulation schemes was shown, and the results prove that M-ary QAM(M-QAM) demonstrates better performance compared to M-DPSK and M-PSK under all fading and non-fading conditions.展开更多
[Objectives] To study the effects of Tiaomaiyin and its disassembled prescription on expression of L-type calcium channel β2 subunit in rat model of tachyarrhythmia. [Methods] Sixty Wistar rats were randomly divided ...[Objectives] To study the effects of Tiaomaiyin and its disassembled prescription on expression of L-type calcium channel β2 subunit in rat model of tachyarrhythmia. [Methods] Sixty Wistar rats were randomly divided into model group,Tiaomaiyin prescription group( whole prescription group),main efficacy group of removing heat to cool blood( blood cooling group),and auxiliary drug efficacy group of benefiting qi and nourishing heart( qi benefiting group),auxiliary efficacy group of promoting flow of qi and blood circulation( qi flow promoting group),and amiodarone group( western medicine group). Aconitine was given 7 d after the intragastric administration of the corresponding drugs,and the time of occurrence of arrhythmia in each group was observed. The left ventricular myocardium was subjected to reverse transcription-polymerase chain reaction and Western blotting. [Results] The ventricular premature beats( VPB) time in the whole prescription group and western medicine group was significantly longer than that in the model group. Ventricular tachycardia( VT),ventricular fibrillation( VF),and cardiac arrest( CA) were longer in the whole prescription group,blood cooling group,and western medicine group. The mRNA and protein expression of L-type calcium channel β2 subunit in the whole prescription group,blood cooling group and western medicine group were significantly decreased. [Conclusions] Tiaomaiyin whole prescription group and blood cooling group can reduce the occurrence time of tachyarrhythmia and reduce the expression of LTCC β2 in myocardium.展开更多
The K-V beam through an axisymmetric uniform-focusing channel is studied using the particle-core model. The beam halo-chaos is found, and a sample function controller is proposed based on mechanism of halo formation a...The K-V beam through an axisymmetric uniform-focusing channel is studied using the particle-core model. The beam halo-chaos is found, and a sample function controller is proposed based on mechanism of halo formation and strategy of controlling halo-chaos. We perform multiparticle simulation to control the halo by using the sample function controller. The numerical results show that our control method is effective. We also find that the radial ion density changes when the ion beam is in the channel： not only can the halo-chaos and its regeneration be eliminated by using the sample function control method, but also the density uniformity can be found at the beam＇s centre as long as an appropriate control method is chosen.展开更多
A study has been arranged to investigate the flow of non-Newtonian fluid in a vertical asymmetrical channel using peristalsis. The porous medium allows the electrically conductive fluid to flow in the channel, while a...A study has been arranged to investigate the flow of non-Newtonian fluid in a vertical asymmetrical channel using peristalsis. The porous medium allows the electrically conductive fluid to flow in the channel, while a uniform magnetic field is applied perpendicular to the flow direction. The analysis takes into account the combined influence of heat and mass transfer, including the effects of Soret and Dufour. The flow’s non-Newtonian behavior is characterized using a Casson rheological model. The fluid flow equations are examined within a wave frame of reference that has a wave velocity. The analytic solution is examined using long wavelengths and a small Reynolds number assumption. The stream function, temperature, concentration and heat transfer coefficient expressions are derived. The bvp4c function from MATLAB has been used to numerically solve the transformed equations. The flow characteristics have been analyzed using graphs to demonstrate the impacts of different parameters.展开更多
Characterization of a mobile radio channel plays an important role in designing a reliable wireless communication system. Such channels are analyzed by two state model, namely satisfactory and outage state. This paper...Characterization of a mobile radio channel plays an important role in designing a reliable wireless communication system. Such channels are analyzed by two state model, namely satisfactory and outage state. This paper presents the analysis to estimate fading parameters of wireless channel with omission of certain outage durations which are considered as “Tolerance time”. Minimum outage duration which can be tolerated by a wireless fading channel to achieve desired packet error rate is defined as tolerance time. Normally a system with tolerable minimum outage time is analyzed based on Fade Duration Distribution (FDD) function over Rayleigh channel. In this paper Weibull function is used as FDD for varying tolerance time. The approach is simple and in general applicable from Rayleigh to Nakagami channels. The analysis is extended to study the effect of Tolerance time on channel fading statistics such as Average Fade Duration (AFD) and frequency of outage. Further the effects of various fade margin and Doppler spread on fading parameters are also investigated. The analysis can also be used in case of timeout expiration, connection resetting and congestion window control.展开更多
基金supported by grants from the National Natural Science Foundation of China(91132303,30830035)the National Basic Research Development Program of China (2011CBA00408)the China Postdoctoral Science Foundation(2012M511105)
文摘Ion channels,as membrane proteins,are the sensors of the cell.They act as the first line of communication with the world beyond the plasma membrane and transduce changes in the external and internal environments into unique electrical signals to shape the responses of excitable cells.Because of their importance in cellular communication,ion channels have been intensively studied at the structural and functional levels.Here,we summarize the diverse approaches,including molecular and cellular,chemical,optical,biophysical,and computational,used to probe the structural and functional rearrangements that occur during channel activation（or sensitization）,inactivation（or desensitization）,and various forms of modulation.The emerging insights into the structure and function of ion channels by multidisciplinary approaches allow the development of new pharmacotherapies as well as new tools useful in controlling cellular activity.
基金supported in part by the national natural science foundation of China (NSFC) under Grant61871193in part by the R&D Program of key science and technology fields in Guangdong province under Grant 2019B090912001in part by the Guangzhou Key Field R&D Program under Grant 202206030005
文摘Secret key generation(SKG)is a promising solution to the problem of wireless communications security.As the first step of SKG,channel probing affects it significantly.Although there have been some probing schemes,there is a lack of research on the optimization of the probing process.This study investigates how to optimize correlated parameters to maximize the SKG rate(SKGR)in the time-division duplex(TDD)mode.First,we build a probing model which includes the effects of transmitting power,the probing period,and the dimension of sample vectors.Based on the model,the analytical expression of the SKGR is given.Next,we formulate an optimization problem for maximizing the SKGR and give an algorithm to solve it.We conclude the SKGR monotonically increases as the transmitting power increases.Relevant mathematical proofs are given in this study.From the simulation results,increasing appropriately the probing period and the dimension of the sample vector could increase the SKGR dramatically compared to a yardstick,which indicates the importance of optimizing the parameters related to the channel probing phase.
基金supported by the National Natural Science Foundation of China (81571273,81571274,81501124,81271434,and 81301107)Omics-based precision medicine of epilepsy being entrusted by Key Research Project of the Ministry of Science and Technology of China (2016YFC0904400)+5 种基金the Natural Science Foundation of Guangdong Province,China (2014A030313489)Science and Technology Planning Projects of Guangdong Province,China (2012B031800404 and 2013B051000084)the Department of Education of Guangdong Province,China (2013CXZDA022,2013KJCX0156,and 2012KJCX009)the Foundation for High-level Talents in Higher Education of Guangdong Province,China (2013-167)Yangcheng Scholar Research Projects of Guangzhou Municipal College (12A016S and 12A017G)Science and Technology Projects of Guangzhou,Guangdong Province,China (2014J4100069,201508020011,201604020161,and 201607010002)
文摘Ion channels are crucial in the generation and modulation of excitability in the nervous system and have been implicated in human epilepsy. Forty-one epilepsyassociated ion channel genes and their mutations are systematically reviewed. In this paper, we analyzed the genotypes, functional alterations（funotypes）, and phenotypes of these mutations. Eleven genes featured loss-offunction mutations and six had gain-of-function mutations.Nine genes displayed diversified funotypes, among which a distinct funotype-phenotype correlation was found in SCN1A. These data suggest that the funotype is an essential consideration in evaluating the pathogenicity of mutations and a distinct funotype or funotype-phenotype correlation helps to define the pathogenic potential of a gene.
文摘Vascular smooth muscle cells（VSMCs） are the major component of vascular wall which are often stretched and compressed by pounding intravascular pressure.These mechanical signals are usually transformed to electrical signals by the opening or closing of ion channels in VSNCs and endothelial cells.Intravascular pressure causes a graded membrane potential depolarization of the VSMCs and leads to vasoconstriction（i.e.,myogenic response）,independent of the vascular endothelium. Although the important role of cation channels including L-type Ca<sup>2+</sup> channels,K<sup>+</sup> channels,and TRP channels in the regulation of vascular tone has been well established the functional roles played by Cl<sup>-</sup> channels in the regulation of the membrane potential and vascular tone remain essentially obscure. Recent emerging evidence implicates very important roles of Cl<sup>-</sup> channels in vascular function ranging from the control of membrane potential equilibrium, vascular contraction and relaxation to the regulation of intracellular pH,cell volume homeostasis,cell proliferation,migration,and apoptosis.
基金Supported by the National Natural Science Foundation of China under Grant Nos 11247010,11175055,11475053 and 11347017the Natural Science Foundation of Hebei Province under Grant Nos C2012202079 and C201400305
文摘We find that a conserved mutation residue Glu to residue Asp （E303D）, which both have the same polar and charged properties, makes Kit2.1 protein lose its function. To understand the mechanism, we identify three interactions which control the conformation change and maintain the function of the Kit2.1 protein by combining homology modeling and molecular dynamics with targeted molecular dynamics. We find that the E303D mutation weakens these interactions and results in the loss of the related function. Our data indicate that not only the amino residues but also the interactions determine the function of proteins.
文摘In this paper, we propose a new multi-user Rake receiver, based on the interference mutualization with a matrix representation for Multiple Input Single Output MISO channel. The proposed system used the Modified Gegenbauer functions in order to generate the signal and to ensure the multi users transmission system. The new proposed receiver allows, using the temporal and special diversity, to avoid the interferences between symbols and to improve the system performances in terms of Bit Error Rate BER and interferences between users with a low algorithm complexity. The proposed solution is based on the classical Rake receiver associated with the equalizer receiver. In order to adapt the Rake approach, in single detection case and in multi users Ultra Wide Band environment, we propose a multi-user Rake receiver using the matrix form. Our proposed system is evaluated in terms of channel effects and multi users’ interferences.
文摘This paper presents a performance study of the distributed coordination function （DCF） of 802.11 networks considering erroneous channel and capture effects under non-saturated traffic conditions employing a basic access method.The aggregate throughput of a practical wireless local area network （WLAN） strongly depends on the channel conditions.In a real radio environment,the received signal power at the access point from a station is subjected to deterministic path loss,shadowing,and fast multipath fading.The binary exponential backoff （BEB） mechanism of IEEE 802.11 DCF severely suffers from more channel idle time under high bit error rate （BER）.To alleviate the low performance of IEEE 802.11 DCF,a new mechanism is introduced,which greatly outperforms the existing methods under a high BER.A multidimensional Markov chain model is used to characterize the behavior of DCF in order to account both non-ideal channel conditions and capture effects.
基金supported in part by National Science Foundation for Distinguished Young Scholars of China with Grant number 61325004Major Program of National Natural Science Foundation of Hubei in China with Grant number 2016CFA009+2 种基金the Fundamental Research Funds for the Central Universities with Grant number 2015ZDTD012the National Natural Science Foundation of China under Grant No.61463035the Research Foundation of the Education Department of Jiangxi Province under Grant No.GJJ150198
文摘In this paper, a free-space vortex channel model of the radio vortex system is proposed to describe the propagation characteristics of vortex signals over the vortex channel. The key idea is to combine the Laguerre-Gaussian(LG) modes in the optical field with the free-space propagation model in the radio field. The proposed free-space vortex channel model is derived from the electric field expression of the LG modes and the freespace channel transfer function of the freespace propagation model theoretically. Simulation results verify that the proposed model could reflect the vortex channel characteristics better than the currently used free-space propagation model.
基金supported by the Beijing Municipal Natural Science Foundation(7142123)
文摘Hyperpolarization-activated and cyclic nucleotide-gated(HCN) channels,distributing in a variety of tissues,especially in excitable cells such as heart cells and many kinds of neurons,have an important role in the modulation of heart rate and neuronal excitability.Different from typical voltage-gated sodium channels and potassium channels,HCN channels were evoked inward currents when the cell was hyperpolarized.More and more recent studies have disclosed that HCN channels play important roles in the nervous system,which were linked with its special electrophysiological features as well as its regulatory effect on the cellular membrane excitability.HCN channels could be modulated by many factors including both extracellular molecules and intracellular signaling cascades,which made its functions complicated in the different condition.Based on its role,HCN channels are presumed to be a promising target for chronic pain and brain disorders.In this paper,we will focus on the advancement of roles of HCN channels in the neural system as well as its complex modulator factors.
基金Project supported by Research Fund Chosun University 2014,Korea
文摘The nature of a wireless communication channel is very unpredictable. To design a good communication link, it is required to know the statistical model of the channel accurately. The average symbol error probability(ASER) was analyzed for different modulation schemes. A unified analytical framework was presented to obtain closed-form solutions for calculating the ASER of M-ary differential phase-shift keying(M-DPSK), coherent M-ary phase-shift keying(M-PSK), and quadrature amplitude modulation(QAM) over single or multiple Nakagami-m fading channels. Moreover, the ASER was estimated and evaluated by using the maximal ratio-combining(MRC) diversity technique. Simulation results show that an error rate of the fading channel typically depends on Nakagami parameters(m), space diversity(N), and symbol rate(M). A comparison between M-PSK, M-DPSK, and M-QAM modulation schemes was shown, and the results prove that M-ary QAM(M-QAM) demonstrates better performance compared to M-DPSK and M-PSK under all fading and non-fading conditions.
基金Supported by the Project of Beijing Municipal Natural Science Foundation(7173261)
文摘[Objectives] To study the effects of Tiaomaiyin and its disassembled prescription on expression of L-type calcium channel β2 subunit in rat model of tachyarrhythmia. [Methods] Sixty Wistar rats were randomly divided into model group,Tiaomaiyin prescription group( whole prescription group),main efficacy group of removing heat to cool blood( blood cooling group),and auxiliary drug efficacy group of benefiting qi and nourishing heart( qi benefiting group),auxiliary efficacy group of promoting flow of qi and blood circulation( qi flow promoting group),and amiodarone group( western medicine group). Aconitine was given 7 d after the intragastric administration of the corresponding drugs,and the time of occurrence of arrhythmia in each group was observed. The left ventricular myocardium was subjected to reverse transcription-polymerase chain reaction and Western blotting. [Results] The ventricular premature beats( VPB) time in the whole prescription group and western medicine group was significantly longer than that in the model group. Ventricular tachycardia( VT),ventricular fibrillation( VF),and cardiac arrest( CA) were longer in the whole prescription group,blood cooling group,and western medicine group. The mRNA and protein expression of L-type calcium channel β2 subunit in the whole prescription group,blood cooling group and western medicine group were significantly decreased. [Conclusions] Tiaomaiyin whole prescription group and blood cooling group can reduce the occurrence time of tachyarrhythmia and reduce the expression of LTCC β2 in myocardium.
基金Project supported by the National Natural Science Foundation of China （Grant Nos 10247005 and 70071047） and the Scientific Research Foundation of China University of Mining and Technology for the Young （Grant No 2005A037）.
文摘The K-V beam through an axisymmetric uniform-focusing channel is studied using the particle-core model. The beam halo-chaos is found, and a sample function controller is proposed based on mechanism of halo formation and strategy of controlling halo-chaos. We perform multiparticle simulation to control the halo by using the sample function controller. The numerical results show that our control method is effective. We also find that the radial ion density changes when the ion beam is in the channel： not only can the halo-chaos and its regeneration be eliminated by using the sample function control method, but also the density uniformity can be found at the beam＇s centre as long as an appropriate control method is chosen.
文摘A study has been arranged to investigate the flow of non-Newtonian fluid in a vertical asymmetrical channel using peristalsis. The porous medium allows the electrically conductive fluid to flow in the channel, while a uniform magnetic field is applied perpendicular to the flow direction. The analysis takes into account the combined influence of heat and mass transfer, including the effects of Soret and Dufour. The flow’s non-Newtonian behavior is characterized using a Casson rheological model. The fluid flow equations are examined within a wave frame of reference that has a wave velocity. The analytic solution is examined using long wavelengths and a small Reynolds number assumption. The stream function, temperature, concentration and heat transfer coefficient expressions are derived. The bvp4c function from MATLAB has been used to numerically solve the transformed equations. The flow characteristics have been analyzed using graphs to demonstrate the impacts of different parameters.
文摘Characterization of a mobile radio channel plays an important role in designing a reliable wireless communication system. Such channels are analyzed by two state model, namely satisfactory and outage state. This paper presents the analysis to estimate fading parameters of wireless channel with omission of certain outage durations which are considered as “Tolerance time”. Minimum outage duration which can be tolerated by a wireless fading channel to achieve desired packet error rate is defined as tolerance time. Normally a system with tolerable minimum outage time is analyzed based on Fade Duration Distribution (FDD) function over Rayleigh channel. In this paper Weibull function is used as FDD for varying tolerance time. The approach is simple and in general applicable from Rayleigh to Nakagami channels. The analysis is extended to study the effect of Tolerance time on channel fading statistics such as Average Fade Duration (AFD) and frequency of outage. Further the effects of various fade margin and Doppler spread on fading parameters are also investigated. The analysis can also be used in case of timeout expiration, connection resetting and congestion window control.
