Aimed at the stabilization of the nonholonomic chained system under fixed sample control, two control laws were proposed. The discrete model of the nonholonomic chained system under zero-hold was obtained through the ...Aimed at the stabilization of the nonholonomic chained system under fixed sample control, two control laws were proposed. The discrete model of the nonholonomic chained system under zero-hold was obtained through the integrate method to the continuous model. And the discrete model was transformed to the form with two linear subsystems through coordinate transformation. Two feedback control laws, time-invariant control law and time-varying control law, were proposed; and the local stabilization and global stabilization were realized respectively. The simulation results show the effectiveness of the proposed control laws. The discrete nonholonomic chained system can converge to zero from any initial state exponentially, and the convergence rate can be changed through changing the parameters of the control laws.展开更多
Short-chain fatty acids,metabolites produced by the fermentation of dietary fiber by gut microbiota,have garnered significant attention due to their correlation with neurodegenerative diseases,particularly Parkinson’...Short-chain fatty acids,metabolites produced by the fermentation of dietary fiber by gut microbiota,have garnered significant attention due to their correlation with neurodegenerative diseases,particularly Parkinson’s disease.In this review,we summarize the changes in short-chain fatty acid levels and the abundance of short-chain fatty acid-producing bacteria in various samples from patients with Parkinson’s disease,highlighting the critical role of gut homeostasis imbalance in the pathogenesis and progression of the disease.Focusing on the nervous system,we discuss the molecular mechanisms by which short-chain fatty acids influence the homeostasis of both the enteric nervous system and the central nervous system.We identify key processes,including the activation of G protein-coupled receptors and the inhibition of histone deacetylases by short-chain fatty acids.Importantly,structural or functional disruptions in the enteric nervous system mediated by these fatty acids may lead to abnormalα-synuclein expression and gastrointestinal dysmotility,which could serve as an initiating event in Parkinson’s disease.Furthermore,we propose that short-chain fatty acids help establish communication between the enteric nervous system and the central nervous system via the vagal nerve,immune circulation,and endocrine signaling.This communication may shed light on their potential role in the transmission ofα-synuclein from the gut to the brain.Finally,we elucidate novel treatment strategies for Parkinson’s disease that target short-chain fatty acids and examine the challenges associated with translating short-chain fatty acid-based therapies into clinical practice.In conclusion,this review emphasizes the pivotal role of short-chain fatty acids in regulating gut-brain axis integrity and their significance in the pathogenesis of Parkinson’s disease from the perspective of the nervous system.Moreover,it highlights the potential value of short-chain fatty acids in early intervention for Parkinson’s disease.Future research into the molecular mechanisms of short-chain fatty acids and their synergistic interactions with other gut metabolites is likely to advance the clinical translation of innovative short-chain fatty acid-based therapies for Parkinson’s disease.展开更多
Ossiculoplasty remains a challenging surgical procedure,with outcomes heavily influenced by diverse anatomical and pathological factors.Over the decades,numerous scoring systems have been developed to predict the prog...Ossiculoplasty remains a challenging surgical procedure,with outcomes heavily influenced by diverse anatomical and pathological factors.Over the decades,numerous scoring systems have been developed to predict the prognosis of ossiculoplasty,each emphasizing different variables such as ossicular status,middle ear environment,and surgical history.This paper provides a comprehensive review of the evolution of prognostic scoring systems,including Austin's original ossicular classification,Bellucci's otorrhea staging,the Middle Ear Risk Index(MERI),the Ossiculoplasty Outcome Parameter Staging(OOPS),and the recently introduced Ear Environment Risk(EER)scale.While these systems have significantly contributed to preoperative assessment,each presents notable limitations in encompassing all variables affecting surgical success.Therefore,the aim of this paper is to provide a review of the ossiculoplasty prognostic scores and show the benefits,innovations and gaps associated with each.To address these gaps,a novel,modified scoring system is proposed,incorporating previously overlooked but clinically significant factors such as tympanic membrane status,type of tympanoplasty,ossicular replacement material,CT scan findings,and the presence of complicated ear conditions.By synthesizing elements from historical scores with updated clinical insights,the proposed system aims to provide a more holistic and predictive framework for preoperative evaluation.Future multicenter studies are encouraged to validate the efficacy and prognostic power of this new scoring system,with the goal of improving surgical planning and patient counseling in ossiculoplasty.展开更多
This paper reviews some main results and progress concerning with nonholonomic system control,especially focusing on the networked chained system coordination.The controllability of nonholonomic system,the control met...This paper reviews some main results and progress concerning with nonholonomic system control,especially focusing on the networked chained system coordination.The controllability of nonholonomic system,the control method of nonholonomic system,the chained form transformation,the basic graph theory for multi-agent systems are recalled,respectively.Some important definitions,lemmas,theorems and dynamics are elaborated.Both the consensus and formation control problems for networked nonholonomic chained systems are summarised.Finally,some open questions are proposed.展开更多
The exponential stabilization problem of a robot-camera system with unknown camera parameters is investigated. Based on the visual feedback and the state-input transformation, an uncertain chained form model is presen...The exponential stabilization problem of a robot-camera system with unknown camera parameters is investigated. Based on the visual feedback and the state-input transformation, an uncertain chained form model is presented for a type of nonholonomic mobile robots. Then, a new time-varying feedback controller is proposed to stabilize the uncertain system exponentially with the help of the stabilization theorems, state-scaling and switching techniques. The exponential stability of the closed-loop system is rigorously proved. Simulation results are given to demonstrate the effectiveness of the proposed strategies.展开更多
The visual serving stabilization for a kind of nonholonomic mobile robots with uncalibrated camera parameters is investigated based on the visual feedback and the state and input transforma- tions. The authors obtain ...The visual serving stabilization for a kind of nonholonomic mobile robots with uncalibrated camera parameters is investigated based on the visual feedback and the state and input transforma- tions. The authors obtain a new uncertain model of the nonholonomic kinematic system in the image plane, which is a chained form with uncalibrated visual parameters, from the camera robotic system. A new time varying feedback controller is proposed for the exponential stabilization of the nonholonomic chained system with unknown parameters by using state-scaling and switching technique. The exponential stability of the closed loop system is rigorously proved. Simulation results demonstrate the effectiveness of the proposed methods.展开更多
Antimicrobial resistance(AMR)has emerged as a critical public health threat and one of the most complicated global challenges due to its multi-faceted nature.In addition to health burden,AMR also drives up healthcare ...Antimicrobial resistance(AMR)has emerged as a critical public health threat and one of the most complicated global challenges due to its multi-faceted nature.In addition to health burden,AMR also drives up healthcare costs and imposes substantial indirect economic impacts.Despite the ongoing global efforts,the burden of drugresistant infections is still growing and alarming.Although AMR has been well addressed pertaining to human health,AMR linked to pathogens in other pillars of the food chain has been a hidden menace and a growing public health concern.AMR may arise in the food chain through various pathways,with foodborne drug-resistant pathogens being reported in the literature.Tackling and combatting AMR in the food chain requires a multifaceted comprehensive approach under the One Health umbrella.This approach is crucial not only to protect public health but also to ensure the sustainability and safety of all components of the food chain.展开更多
Ultra-high molecular weight polyethylene(UHMWPE)is widely utilized in low-dimensional materials due to its ultra-long chain imparted excellent strength and modulus.By employing gel-molding technology with a gradient t...Ultra-high molecular weight polyethylene(UHMWPE)is widely utilized in low-dimensional materials due to its ultra-long chain imparted excellent strength and modulus.By employing gel-molding technology with a gradient temperature control,this study successfully produced gel films with varying shish crystal contents of the UHMWPE with a molecular weight of 8.0 million.The structural evolution during film hotstretching was investigated by in-situ wide-angle X-ray diffraction(WAXD),small-angle X-ray scattering(SAXS),ultra-small-angle X-ray scattering(USAXS),and ex-situ methods of scanning electron microscopy(SEM)and differential scanning calorimetry(DSC).The ultra-long molecular chains delay stress transfer during stretching but provide more nucleation sites for shish-kebab crystallization to form well-ordered shish-kebab crystals under high strain.The reserved high-content shish facilitates structural evolution,inducing the formation of highly-ordered shish-kebab crystals that eventually transfer into shish crystals in the later stage of stretching.The samples with low shish content,although the structural evolution is facilitated during stretching,predominantly result in newly formed shish-kebab crystals through melt recrystallization.However,some unoriented lamellae persists in unreserved samples stretching progress,leading to less ordered shish-kebab structures.By comparing with previous work of UHMWPE with low molecular weights,we demonstrate that the ultra-long molecular chains also play a key role on enabling the construction of highly-ordered shish-kebab crystals with high shish content during hot-stretching of UHMWPE gel films,providing new insights into processing control and optimization for engineering applications.展开更多
The prebiotic effects of hyaluronan(HA)are widely recognized,contributing to improved gut health and immune modulation.Despite its extensive use as dietary supplement,the specific interactions between HA oligosacchari...The prebiotic effects of hyaluronan(HA)are widely recognized,contributing to improved gut health and immune modulation.Despite its extensive use as dietary supplement,the specific interactions between HA oligosaccharides(o-HAs)and the gut microbiome remain largely unexplored.To investigate its role and metabolic fate in gut homeostasis,200 mg/day of o-HAs(average molecule weight 1 kDa)were added to an automated computer-controlled SIMulator of the Gastrointestinal tract(SIMGI).The results revealed a significant reshaping of the intestinal flora composition by o-HAs,notably reducing the Firmicutes/Bacteroides ratio.Fermentation of o-HAs by gut microbiota significantly increased the abundance of Bifidobacterium,Prevotellaceae_Prevotella,Dialister,Eubacterium,and Sutterella,but decreased that of Catenibacterium,Oscillospira,Klebsiella,and Citrobacter(P<0.05).This corresponded with significant enhancements in the content of short-chain fatty acids(SCFAs)such as acetic acid,propionic acid and n-butyric acid,highlighting the significant impact of o-HAs at the genus level.Furthermore,analysis of microbial function predicted the downregulation of pathological events in nine human diseases,particularly infectious ones(parasitic and bacterial).Potential inhibitions were observed in metabolic pathways associated with pentose and glucuronate interconversions as well as cationic antimicrobial peptide resistance.These findings underscore the in vitro prebiotic effects of o-HAs and their potential relevance in managing diverticular diseases or preventing metabolic disorders through the regulation of gut microbiota.展开更多
The present study was conducted to examine the trophic transfer of potentially toxic elements(PTEs)in a closed arsenic mine.Eight PTEs in a soil-plant-leaf litter-earthworm-top predators(free-range local chicken and w...The present study was conducted to examine the trophic transfer of potentially toxic elements(PTEs)in a closed arsenic mine.Eight PTEs in a soil-plant-leaf litter-earthworm-top predators(free-range local chicken and wild passerine bird)system were analyzed for nitrogen and carbon stable isotopes,PTE concentrations,bioaccumulation factors(BAFs),and transfer factors(TFs).The PTE concentrations in soils from mining areas were generally higher than a adjacent controlled area,with As and Cd in soils showing the prominent compared to other six PTEs,as seen for the indices of geo-accumulation index(I_(geo)),pollution index(PI)and potential ecological risk index(RI).The relatively high BAF and TF values suggested a distinct biotransfer of PTEs along the soil-plant-leaf litter-earthworm system.BAFs were mostly<1 except in earthworms,indicating that earthworms had a strong capacity to take up these metals.The TFs varied both among PTEs and organism’s species,e.g.,the transfer capacities of As in Pteris vittata and Pteris cretica,Cd in Miscanthus sinensis,and Pb,Cr and Mn in moss were the highest.For local free-range chicken and wild passerine bird,the concentrations of PTEs were higher in gastric contents and feather than in internal tissue(stomach,liver and heart),with lower contents in muscle and egg.Bioaccumulation of PTEs generally decreased from decomposer earthworms,to primary producer plants,to top predator,indicating a potential bio-dilution tendency in higher trophic levels in the terrestrial food chain.展开更多
Background: The availability of essential medicines and medical supplies is crucial for effectively delivering healthcare services. In Zambia, the Logistics Management Information System (LMIS) is a key tool for manag...Background: The availability of essential medicines and medical supplies is crucial for effectively delivering healthcare services. In Zambia, the Logistics Management Information System (LMIS) is a key tool for managing the supply chain of these commodities. This study aimed to evaluate the effectiveness of LMIS in ensuring the availability of essential medicines and medical supplies in public hospitals in the Copperbelt Province of Zambia. Materials and Methods: From February to April 2022, a cross-sectional study was conducted in 12 public hospitals across the Copperbelt Province. Data were collected using structured questionnaires, checklists, and stock control cards. The study assessed LMIS availability, training, and knowledge among pharmacy personnel, as well as data accuracy, product availability, and order fill rates. Descriptive statistics were used to analyse the data. Results: All surveyed hospitals had LMIS implemented and were using eLMIS as the primary LMIS. Only 47% and 48% of pharmacy personnel received training in eLMIS and Essential Medicines Logistics Improvement Program (EMLIP), respectively. Most personnel demonstrated good knowledge of LMIS, with 77.7% able to log in to eLMIS Facility Edition, 76.6% able to locate stock control cards in the system, and 78.7% able to perform transactions. However, data accuracy from physical and electronic records varied from 0% to 60%, and product availability ranged from 50% to 80%. Order fill rates from Zambia Medicines and Medical Supplies Agency (ZAMMSA) were consistently below 30%. Discrepancies were observed between physical stock counts and eLMIS records. Conclusion: This study found that most hospitals in the Copperbelt Province of Zambia have implemented LMIS use. While LMIS implementation is high in the Copperbelt Province of Zambia, challenges such as low training levels, data inaccuracies, low product availability, and order fill rates persist. Addressing these issues requires a comprehensive approach, including capacity building, data quality improvement, supply chain coordination, and investment in infrastructure and human resources. Strengthening LMIS effectiveness is crucial for improving healthcare delivery and patient outcomes in Zambia.展开更多
As Internet ofThings(IoT)technologies continue to evolve at an unprecedented pace,intelligent big data control and information systems have become critical enablers for organizational digital transformation,facilitati...As Internet ofThings(IoT)technologies continue to evolve at an unprecedented pace,intelligent big data control and information systems have become critical enablers for organizational digital transformation,facilitating data-driven decision making,fostering innovation ecosystems,and maintaining operational stability.In this study,we propose an advanced deployment algorithm for Service Function Chaining(SFC)that leverages an enhanced Practical Byzantine Fault Tolerance(PBFT)mechanism.The main goal is to tackle the issues of security and resource efficiency in SFC implementation across diverse network settings.By integrating blockchain technology and Deep Reinforcement Learning(DRL),our algorithm not only optimizes resource utilization and quality of service but also ensures robust security during SFC deployment.Specifically,the enhanced PBFT consensus mechanism(VRPBFT)significantly reduces consensus latency and improves Byzantine node detection through the introduction of a Verifiable Random Function(VRF)and a node reputation grading model.Experimental results demonstrate that compared to traditional PBFT,the proposed VRPBFT algorithm reduces consensus latency by approximately 30%and decreases the proportion of Byzantine nodes by 40%after 100 rounds of consensus.Furthermore,the DRL-based SFC deployment algorithm(SDRL)exhibits rapid convergence during training,with improvements in long-term average revenue,request acceptance rate,and revenue/cost ratio of 17%,14.49%,and 20.35%,respectively,over existing algorithms.Additionally,the CPU resource utilization of the SDRL algorithmreaches up to 42%,which is 27.96%higher than other algorithms.These findings indicate that the proposed algorithm substantially enhances resource utilization efficiency,service quality,and security in SFC deployment.展开更多
Rice straw,a by-product of rice cultivation,is commonly disposed of through open-field burning,which contributes to air pollution and environmental degradation.This study aims to identify the key factors influencing f...Rice straw,a by-product of rice cultivation,is commonly disposed of through open-field burning,which contributes to air pollution and environmental degradation.This study aims to identify the key factors influencing farmers’decisions on rice straw management and to develop policy recommendations that encourage the sustainable utilization of rice straw within the supply chain.A mixed-methods approach was adopted,combining qualitative interviews with nine key informants and a quantitative survey of 585 rice farmers across Thailand.Multinomial Logit Regression(MLR)was employed to analyze farmers’preferences among four management options:burning,composting,animal feeding,and selling.The results reveal that membership in farmer groups,ownership of livestock,access to baling machinery,knowledge,and skills related to straw utilization,ease of field access,availability of storage facilities,engagement in integrated farming,and year-round access to baling services significantly increased the likelihood of choosing sustainable alternatives over the burning straw.These findings underscore the importance of both capacity-building and infrastructure in enabling sustainable practices.Based on these insights,the study proposes a multi-level policy framework to enhance the value creation of rice straw.National policies should focus on expanding access to machinery and supporting innovation,while local governments should facilitate farmer training and improve straw logistics.Strengthening farmer organizations and market connections is also crucial for scaling adoption.Overall,structural integration and stakeholder coordination are key to reducing straw burning and promoting sustainable resource use in rice-producing regions.展开更多
New renewable energy exploitation technologies in offshore structures are vital for future energy production systems.Offshore hybrid wind-wave power generation(HWWPG)systems face increased component failure rates beca...New renewable energy exploitation technologies in offshore structures are vital for future energy production systems.Offshore hybrid wind-wave power generation(HWWPG)systems face increased component failure rates because of harsh weather,significantly affecting the maintenance procedures and reliability.Different types of failure rates of the wind turbine(WT)and wave energy converter(WEC),e.g.,the degradation and failure rates during regular wind speed fluctuation,the degradation and failure rates during intense wind speed fluctuation are considered.By incorporating both WT and WEC,the HWWPG system is designed to enhance the overall amount of electrical energy produced by the system over a given period under varying weather conditions.The universal generating function technique is used to calculate the HWWPG system dependability measures in a structured and efficient manner.This research highlights that intense weather conditions increase the failure rates of both WT and WEC,resulting in higher maintenance costs and more frequent downtimes,thus impacting the HWWPG system’s reliability.Although the HWWPG system can meet the energy demands in the presence of high failure rates,the reliance of the hybrid system on both WT and WEC helps maintain a relatively stable demand satisfaction during periods of high energy demand despite adverse weather conditions.To confirm the added value and applicability of the developed model,a case study of an offshore hybrid platform is conducted.The findings underscore the system’s robustness in maintaining energy production under varied weather conditions,though higher failure rates and maintenance costs arise in intense scenarios.展开更多
Traditional supply chain finance has problems in four aspects:business flow,logistics,capital flow,and information flow.Blockchain technologies such as smart contracts and consensus mechanisms can help break through t...Traditional supply chain finance has problems in four aspects:business flow,logistics,capital flow,and information flow.Blockchain technologies such as smart contracts and consensus mechanisms can help break through the above problems.They can improve the implementation effect of supply chain finance,and reduce risks.Based on blockchain technology,this paper constructs a multi-dimensional dynamic supply chain financial risk control system.The system includes multi-dimensional dynamic supply chain financial risk control technology,a credit evaluation system,and a capital monitoring and early warning system.By constructing a multi-dimensional dynamic supply chain financial risk control system,effective risk complete monitoring and penetrating supervision can be achieved.At the same time,this paper introduces technologies such as machine learning and deep learning to build an effective risk control system,which is of great significance for reducing supply chain financial risks.展开更多
Background Despite growing concerns about the adverse effects of antibiotics in farm animals,there has been little investigation of the effects of florfenicol in laying hens.This study examined the effect of florfenic...Background Despite growing concerns about the adverse effects of antibiotics in farm animals,there has been little investigation of the effects of florfenicol in laying hens.This study examined the effect of florfenicol on the intestinal homeostasis,immune system,and pathogen susceptibility of laying hens.Results The oral administration of florfenicol at field-relevant levels for 5 d resulted in a decrease in the gut microbiota genera Lactobacillus,Bacillus,and Bacteroides,indicating the development of intestinal dysbiosis.The dysbiosis led to decreased mRNA levels of key regulators peroxisome proliferator-activated receptor gamma(PPAR-γ)and hypoxia-inducible factor-1α(HIF-1α),compromising intestinal hypoxia.Intestinal homeostasis was also disrupted,with decreased expression of Occludin and Mucin 2(Muc2)genes combined with increased gut epithelial permeability.The breakdown in intestinal homeostasis and immune function provided a favorable environment for opportunistic bacteria like avian pathogenic Escherichia coli(APEC),culminating in systemic infection.Immunologically,florfenicol treatment resulted in increased proportion and absolute number of MRC1L-B^(+)monocytes/macrophages in the spleen,indicating an exacerbated infection.Furthermore,both the proportion and absolute number ofγδT cells in the lamina propria of the cecum decreased.Treatment with florfenicol reduced butyrate levels in the cecum.However,the administration of butyrate before and during florfenicol treatment restored factors associated with intestinal homeostasis,including PPAR-γ,Occludin,and Muc2,while partially restoring HIF-1α,normalized intestinal hypoxia and gut permeability,and reversed immune cell changes,suppressing APEC systemic infection.Conclusion The uncontrolled and widespread use of florfenicol can negatively affect intestinal health in chickens.Specifically,florfenicol was found to impair intestinal homeostasis and immune function in laying hens,including by reducing butyrate levels,thereby increasing their susceptibility to systemic APEC infection.The development of strategies for mitigating the adverse effects of florfenicol on gut health and pathogen susceptibility in laying hens is therefore essential.展开更多
[Objective] The paper is to construct the logistics tracking management system of tropical agricultural products based on supply chain.[Method] With tropical agricultural products in Hainan as study object,based on lo...[Objective] The paper is to construct the logistics tracking management system of tropical agricultural products based on supply chain.[Method] With tropical agricultural products in Hainan as study object,based on logistics supply chain files and electronic tag coding of agricultural products,cold chain temperature and humidity monitoring,vehicle transportation positioning,data exchange of XML Web services and role-based permission dynamic allocation,the multi-level multi-permission and multi-role logistics tracking management system of tropical agricultural products has been established.[Result] The system constructs information exchange platform for various links of logistics supply chain of tropical agricultural products,which realizes the entire quality monitoring and information tracing of agricultural products,thus enhancing the competitiveness of supply chain in company.[Conclusion] The system has good application and extension prospect.展开更多
A new modular solution to the state explosion problem caused by the Markov-based modular solution of dynamic multiple-phased systems is proposed. First, the solution makes full use of the static parts of dynamic multi...A new modular solution to the state explosion problem caused by the Markov-based modular solution of dynamic multiple-phased systems is proposed. First, the solution makes full use of the static parts of dynamic multiple-phased systems and constructs cross-phase dynamic modules by combining the dynamic modules of phase fault trees. Secondly, the system binary decision diagram （BDD） from a modularized multiple- phased system （MPS）is generated by using variable ordering and BDD operations. The computational formulations of the BDD node event probability are derived for various node links and the system reliability results are figured out. Finally, a hypothetical multiple-phased system is given to demonstrate the advantages of the dynamic modular solution when the Markov state space and the size of the system BDD are reduced.展开更多
This article reviewed the inhibition mechanism of long chain fatty acid on the formation of anaerobic system, then thoroughly analyzed the inhibition factors of long chain fatty acid, and summarized the remission meth...This article reviewed the inhibition mechanism of long chain fatty acid on the formation of anaerobic system, then thoroughly analyzed the inhibition factors of long chain fatty acid, and summarized the remission method to its inhibition, finally proposed some suggestions to further study on the influence of long chain fatty acid on anaerobic digestion system.展开更多
[Objective] This study aimed to optimize the PCR amplification conditions for random ssDNA pool in SELEX technology. [Method] L16（45） orthogonal experimental design was adopted for optimization of five important fac...[Objective] This study aimed to optimize the PCR amplification conditions for random ssDNA pool in SELEX technology. [Method] L16（45） orthogonal experimental design was adopted for optimization of five important factors affecting PCR reaction system for random single-stranded DNA pool including Mg2＋ concentration, dNTP concentration, amount of Taq DNA polymerase, primer concentration and amount of random single-stranded DNA pool at four levels. Meanwhile, the annealing temperature and number of PCR reaction cycles were optimized to establish the optimal reaction system and PCR procedure. [Result] The optimal combination of PCR reaction system for random ssDNA pool was obtained, with a total system volume of 20 μl containing 2.0 μl of 10 × Buffer, 0.5 ng of random ssDNA pool, 2.5 mmol/L Mg2＋, 0.25 mmol/L dNTP Mixture, 0.6 μmol/L upstream and downstream primers and 1.5 U of Taq DNA polymerase; the optimal annealing temperature was 68 ℃ and the optimal number of cycles was 12. Under the above conditions, clear and stable bands with high specificity for random ssDNA pool were amplified. [Conclusion] This study laid the foundation for selection of parameters with higher specificity in SELEX technology.展开更多
文摘Aimed at the stabilization of the nonholonomic chained system under fixed sample control, two control laws were proposed. The discrete model of the nonholonomic chained system under zero-hold was obtained through the integrate method to the continuous model. And the discrete model was transformed to the form with two linear subsystems through coordinate transformation. Two feedback control laws, time-invariant control law and time-varying control law, were proposed; and the local stabilization and global stabilization were realized respectively. The simulation results show the effectiveness of the proposed control laws. The discrete nonholonomic chained system can converge to zero from any initial state exponentially, and the convergence rate can be changed through changing the parameters of the control laws.
基金supported by the National Key R&D Program of China,No.2021YFC2501200(to PC).
文摘Short-chain fatty acids,metabolites produced by the fermentation of dietary fiber by gut microbiota,have garnered significant attention due to their correlation with neurodegenerative diseases,particularly Parkinson’s disease.In this review,we summarize the changes in short-chain fatty acid levels and the abundance of short-chain fatty acid-producing bacteria in various samples from patients with Parkinson’s disease,highlighting the critical role of gut homeostasis imbalance in the pathogenesis and progression of the disease.Focusing on the nervous system,we discuss the molecular mechanisms by which short-chain fatty acids influence the homeostasis of both the enteric nervous system and the central nervous system.We identify key processes,including the activation of G protein-coupled receptors and the inhibition of histone deacetylases by short-chain fatty acids.Importantly,structural or functional disruptions in the enteric nervous system mediated by these fatty acids may lead to abnormalα-synuclein expression and gastrointestinal dysmotility,which could serve as an initiating event in Parkinson’s disease.Furthermore,we propose that short-chain fatty acids help establish communication between the enteric nervous system and the central nervous system via the vagal nerve,immune circulation,and endocrine signaling.This communication may shed light on their potential role in the transmission ofα-synuclein from the gut to the brain.Finally,we elucidate novel treatment strategies for Parkinson’s disease that target short-chain fatty acids and examine the challenges associated with translating short-chain fatty acid-based therapies into clinical practice.In conclusion,this review emphasizes the pivotal role of short-chain fatty acids in regulating gut-brain axis integrity and their significance in the pathogenesis of Parkinson’s disease from the perspective of the nervous system.Moreover,it highlights the potential value of short-chain fatty acids in early intervention for Parkinson’s disease.Future research into the molecular mechanisms of short-chain fatty acids and their synergistic interactions with other gut metabolites is likely to advance the clinical translation of innovative short-chain fatty acid-based therapies for Parkinson’s disease.
文摘Ossiculoplasty remains a challenging surgical procedure,with outcomes heavily influenced by diverse anatomical and pathological factors.Over the decades,numerous scoring systems have been developed to predict the prognosis of ossiculoplasty,each emphasizing different variables such as ossicular status,middle ear environment,and surgical history.This paper provides a comprehensive review of the evolution of prognostic scoring systems,including Austin's original ossicular classification,Bellucci's otorrhea staging,the Middle Ear Risk Index(MERI),the Ossiculoplasty Outcome Parameter Staging(OOPS),and the recently introduced Ear Environment Risk(EER)scale.While these systems have significantly contributed to preoperative assessment,each presents notable limitations in encompassing all variables affecting surgical success.Therefore,the aim of this paper is to provide a review of the ossiculoplasty prognostic scores and show the benefits,innovations and gaps associated with each.To address these gaps,a novel,modified scoring system is proposed,incorporating previously overlooked but clinically significant factors such as tympanic membrane status,type of tympanoplasty,ossicular replacement material,CT scan findings,and the presence of complicated ear conditions.By synthesizing elements from historical scores with updated clinical insights,the proposed system aims to provide a more holistic and predictive framework for preoperative evaluation.Future multicenter studies are encouraged to validate the efficacy and prognostic power of this new scoring system,with the goal of improving surgical planning and patient counseling in ossiculoplasty.
基金supported in part by the National Natural Science Foundation of China under[grant number 61321002],[grant number 61120106010],[grant number 61175112]the programme for New Century Excellent Talents in University+1 种基金the Social Science Foundation of Fujian Province under[grant number 2014B182]the Beijing Education Committee Cooperation Building Foundation Project.
文摘This paper reviews some main results and progress concerning with nonholonomic system control,especially focusing on the networked chained system coordination.The controllability of nonholonomic system,the control method of nonholonomic system,the chained form transformation,the basic graph theory for multi-agent systems are recalled,respectively.Some important definitions,lemmas,theorems and dynamics are elaborated.Both the consensus and formation control problems for networked nonholonomic chained systems are summarised.Finally,some open questions are proposed.
基金Supported by the the National Natural Science Foundation of China(Nos.61374040,61304004 and 61473179)Natural Science Foundation of Shandong Province(Nos.ZR2013FM012,ZR2014FM007)
文摘The exponential stabilization problem of a robot-camera system with unknown camera parameters is investigated. Based on the visual feedback and the state-input transformation, an uncertain chained form model is presented for a type of nonholonomic mobile robots. Then, a new time-varying feedback controller is proposed to stabilize the uncertain system exponentially with the help of the stabilization theorems, state-scaling and switching techniques. The exponential stability of the closed-loop system is rigorously proved. Simulation results are given to demonstrate the effectiveness of the proposed strategies.
基金supported by the National Science Foundation under Grant No.60874002Key Project of Shanghai Education Committee under Grant No.09ZZ158+1 种基金Key Discipline of Shanghai under Grant No.S30501Doctoral Fund of Shandong University of Technology under Grant No.411016
文摘The visual serving stabilization for a kind of nonholonomic mobile robots with uncalibrated camera parameters is investigated based on the visual feedback and the state and input transforma- tions. The authors obtain a new uncertain model of the nonholonomic kinematic system in the image plane, which is a chained form with uncalibrated visual parameters, from the camera robotic system. A new time varying feedback controller is proposed for the exponential stabilization of the nonholonomic chained system with unknown parameters by using state-scaling and switching technique. The exponential stability of the closed loop system is rigorously proved. Simulation results demonstrate the effectiveness of the proposed methods.
文摘Antimicrobial resistance(AMR)has emerged as a critical public health threat and one of the most complicated global challenges due to its multi-faceted nature.In addition to health burden,AMR also drives up healthcare costs and imposes substantial indirect economic impacts.Despite the ongoing global efforts,the burden of drugresistant infections is still growing and alarming.Although AMR has been well addressed pertaining to human health,AMR linked to pathogens in other pillars of the food chain has been a hidden menace and a growing public health concern.AMR may arise in the food chain through various pathways,with foodborne drug-resistant pathogens being reported in the literature.Tackling and combatting AMR in the food chain requires a multifaceted comprehensive approach under the One Health umbrella.This approach is crucial not only to protect public health but also to ensure the sustainability and safety of all components of the food chain.
基金supported by the National Natural Science Foundation of China(Nos.52173021,52373038 and 52073149)S&T Innovation 2025 Major Special Programme of Ningbo(No.2023Z079)。
文摘Ultra-high molecular weight polyethylene(UHMWPE)is widely utilized in low-dimensional materials due to its ultra-long chain imparted excellent strength and modulus.By employing gel-molding technology with a gradient temperature control,this study successfully produced gel films with varying shish crystal contents of the UHMWPE with a molecular weight of 8.0 million.The structural evolution during film hotstretching was investigated by in-situ wide-angle X-ray diffraction(WAXD),small-angle X-ray scattering(SAXS),ultra-small-angle X-ray scattering(USAXS),and ex-situ methods of scanning electron microscopy(SEM)and differential scanning calorimetry(DSC).The ultra-long molecular chains delay stress transfer during stretching but provide more nucleation sites for shish-kebab crystallization to form well-ordered shish-kebab crystals under high strain.The reserved high-content shish facilitates structural evolution,inducing the formation of highly-ordered shish-kebab crystals that eventually transfer into shish crystals in the later stage of stretching.The samples with low shish content,although the structural evolution is facilitated during stretching,predominantly result in newly formed shish-kebab crystals through melt recrystallization.However,some unoriented lamellae persists in unreserved samples stretching progress,leading to less ordered shish-kebab structures.By comparing with previous work of UHMWPE with low molecular weights,we demonstrate that the ultra-long molecular chains also play a key role on enabling the construction of highly-ordered shish-kebab crystals with high shish content during hot-stretching of UHMWPE gel films,providing new insights into processing control and optimization for engineering applications.
基金financially supported by the National Natural Science Foundation of China(32000058)the Fundamental Research Funds for the Central Universities(JUSRP622003)。
文摘The prebiotic effects of hyaluronan(HA)are widely recognized,contributing to improved gut health and immune modulation.Despite its extensive use as dietary supplement,the specific interactions between HA oligosaccharides(o-HAs)and the gut microbiome remain largely unexplored.To investigate its role and metabolic fate in gut homeostasis,200 mg/day of o-HAs(average molecule weight 1 kDa)were added to an automated computer-controlled SIMulator of the Gastrointestinal tract(SIMGI).The results revealed a significant reshaping of the intestinal flora composition by o-HAs,notably reducing the Firmicutes/Bacteroides ratio.Fermentation of o-HAs by gut microbiota significantly increased the abundance of Bifidobacterium,Prevotellaceae_Prevotella,Dialister,Eubacterium,and Sutterella,but decreased that of Catenibacterium,Oscillospira,Klebsiella,and Citrobacter(P<0.05).This corresponded with significant enhancements in the content of short-chain fatty acids(SCFAs)such as acetic acid,propionic acid and n-butyric acid,highlighting the significant impact of o-HAs at the genus level.Furthermore,analysis of microbial function predicted the downregulation of pathological events in nine human diseases,particularly infectious ones(parasitic and bacterial).Potential inhibitions were observed in metabolic pathways associated with pentose and glucuronate interconversions as well as cationic antimicrobial peptide resistance.These findings underscore the in vitro prebiotic effects of o-HAs and their potential relevance in managing diverticular diseases or preventing metabolic disorders through the regulation of gut microbiota.
基金supported by the National Natural Science Foundation of China(Nos.41907325 and 41571470).
文摘The present study was conducted to examine the trophic transfer of potentially toxic elements(PTEs)in a closed arsenic mine.Eight PTEs in a soil-plant-leaf litter-earthworm-top predators(free-range local chicken and wild passerine bird)system were analyzed for nitrogen and carbon stable isotopes,PTE concentrations,bioaccumulation factors(BAFs),and transfer factors(TFs).The PTE concentrations in soils from mining areas were generally higher than a adjacent controlled area,with As and Cd in soils showing the prominent compared to other six PTEs,as seen for the indices of geo-accumulation index(I_(geo)),pollution index(PI)and potential ecological risk index(RI).The relatively high BAF and TF values suggested a distinct biotransfer of PTEs along the soil-plant-leaf litter-earthworm system.BAFs were mostly<1 except in earthworms,indicating that earthworms had a strong capacity to take up these metals.The TFs varied both among PTEs and organism’s species,e.g.,the transfer capacities of As in Pteris vittata and Pteris cretica,Cd in Miscanthus sinensis,and Pb,Cr and Mn in moss were the highest.For local free-range chicken and wild passerine bird,the concentrations of PTEs were higher in gastric contents and feather than in internal tissue(stomach,liver and heart),with lower contents in muscle and egg.Bioaccumulation of PTEs generally decreased from decomposer earthworms,to primary producer plants,to top predator,indicating a potential bio-dilution tendency in higher trophic levels in the terrestrial food chain.
文摘Background: The availability of essential medicines and medical supplies is crucial for effectively delivering healthcare services. In Zambia, the Logistics Management Information System (LMIS) is a key tool for managing the supply chain of these commodities. This study aimed to evaluate the effectiveness of LMIS in ensuring the availability of essential medicines and medical supplies in public hospitals in the Copperbelt Province of Zambia. Materials and Methods: From February to April 2022, a cross-sectional study was conducted in 12 public hospitals across the Copperbelt Province. Data were collected using structured questionnaires, checklists, and stock control cards. The study assessed LMIS availability, training, and knowledge among pharmacy personnel, as well as data accuracy, product availability, and order fill rates. Descriptive statistics were used to analyse the data. Results: All surveyed hospitals had LMIS implemented and were using eLMIS as the primary LMIS. Only 47% and 48% of pharmacy personnel received training in eLMIS and Essential Medicines Logistics Improvement Program (EMLIP), respectively. Most personnel demonstrated good knowledge of LMIS, with 77.7% able to log in to eLMIS Facility Edition, 76.6% able to locate stock control cards in the system, and 78.7% able to perform transactions. However, data accuracy from physical and electronic records varied from 0% to 60%, and product availability ranged from 50% to 80%. Order fill rates from Zambia Medicines and Medical Supplies Agency (ZAMMSA) were consistently below 30%. Discrepancies were observed between physical stock counts and eLMIS records. Conclusion: This study found that most hospitals in the Copperbelt Province of Zambia have implemented LMIS use. While LMIS implementation is high in the Copperbelt Province of Zambia, challenges such as low training levels, data inaccuracies, low product availability, and order fill rates persist. Addressing these issues requires a comprehensive approach, including capacity building, data quality improvement, supply chain coordination, and investment in infrastructure and human resources. Strengthening LMIS effectiveness is crucial for improving healthcare delivery and patient outcomes in Zambia.
基金supported by the National Natural Science Foundation of China under Grant 62471493 and 62402257partially supported by the Natural Science Foundation of Shandong Province under Grant ZR2023LZH017,ZR2024MF066 and 2023QF025+2 种基金partially supported by the Open Research Subject of State Key Laboratory of Intelligent Game(No.ZBKF-24-12)partially supported by the Foundation of Key Laboratory of Education Informatization for Nationalities(Yunnan Normal University),the Ministry of Education(No.EIN2024C006)partially supported by the Key Laboratory of Ethnic Language Intelligent Analysis and Security Governance of MOE(No.202306).
文摘As Internet ofThings(IoT)technologies continue to evolve at an unprecedented pace,intelligent big data control and information systems have become critical enablers for organizational digital transformation,facilitating data-driven decision making,fostering innovation ecosystems,and maintaining operational stability.In this study,we propose an advanced deployment algorithm for Service Function Chaining(SFC)that leverages an enhanced Practical Byzantine Fault Tolerance(PBFT)mechanism.The main goal is to tackle the issues of security and resource efficiency in SFC implementation across diverse network settings.By integrating blockchain technology and Deep Reinforcement Learning(DRL),our algorithm not only optimizes resource utilization and quality of service but also ensures robust security during SFC deployment.Specifically,the enhanced PBFT consensus mechanism(VRPBFT)significantly reduces consensus latency and improves Byzantine node detection through the introduction of a Verifiable Random Function(VRF)and a node reputation grading model.Experimental results demonstrate that compared to traditional PBFT,the proposed VRPBFT algorithm reduces consensus latency by approximately 30%and decreases the proportion of Byzantine nodes by 40%after 100 rounds of consensus.Furthermore,the DRL-based SFC deployment algorithm(SDRL)exhibits rapid convergence during training,with improvements in long-term average revenue,request acceptance rate,and revenue/cost ratio of 17%,14.49%,and 20.35%,respectively,over existing algorithms.Additionally,the CPU resource utilization of the SDRL algorithmreaches up to 42%,which is 27.96%higher than other algorithms.These findings indicate that the proposed algorithm substantially enhances resource utilization efficiency,service quality,and security in SFC deployment.
文摘Rice straw,a by-product of rice cultivation,is commonly disposed of through open-field burning,which contributes to air pollution and environmental degradation.This study aims to identify the key factors influencing farmers’decisions on rice straw management and to develop policy recommendations that encourage the sustainable utilization of rice straw within the supply chain.A mixed-methods approach was adopted,combining qualitative interviews with nine key informants and a quantitative survey of 585 rice farmers across Thailand.Multinomial Logit Regression(MLR)was employed to analyze farmers’preferences among four management options:burning,composting,animal feeding,and selling.The results reveal that membership in farmer groups,ownership of livestock,access to baling machinery,knowledge,and skills related to straw utilization,ease of field access,availability of storage facilities,engagement in integrated farming,and year-round access to baling services significantly increased the likelihood of choosing sustainable alternatives over the burning straw.These findings underscore the importance of both capacity-building and infrastructure in enabling sustainable practices.Based on these insights,the study proposes a multi-level policy framework to enhance the value creation of rice straw.National policies should focus on expanding access to machinery and supporting innovation,while local governments should facilitate farmer training and improve straw logistics.Strengthening farmer organizations and market connections is also crucial for scaling adoption.Overall,structural integration and stakeholder coordination are key to reducing straw burning and promoting sustainable resource use in rice-producing regions.
文摘New renewable energy exploitation technologies in offshore structures are vital for future energy production systems.Offshore hybrid wind-wave power generation(HWWPG)systems face increased component failure rates because of harsh weather,significantly affecting the maintenance procedures and reliability.Different types of failure rates of the wind turbine(WT)and wave energy converter(WEC),e.g.,the degradation and failure rates during regular wind speed fluctuation,the degradation and failure rates during intense wind speed fluctuation are considered.By incorporating both WT and WEC,the HWWPG system is designed to enhance the overall amount of electrical energy produced by the system over a given period under varying weather conditions.The universal generating function technique is used to calculate the HWWPG system dependability measures in a structured and efficient manner.This research highlights that intense weather conditions increase the failure rates of both WT and WEC,resulting in higher maintenance costs and more frequent downtimes,thus impacting the HWWPG system’s reliability.Although the HWWPG system can meet the energy demands in the presence of high failure rates,the reliance of the hybrid system on both WT and WEC helps maintain a relatively stable demand satisfaction during periods of high energy demand despite adverse weather conditions.To confirm the added value and applicability of the developed model,a case study of an offshore hybrid platform is conducted.The findings underscore the system’s robustness in maintaining energy production under varied weather conditions,though higher failure rates and maintenance costs arise in intense scenarios.
基金supported by Sichuan Science and Technology Program(2024YFHZ0161).
文摘Traditional supply chain finance has problems in four aspects:business flow,logistics,capital flow,and information flow.Blockchain technologies such as smart contracts and consensus mechanisms can help break through the above problems.They can improve the implementation effect of supply chain finance,and reduce risks.Based on blockchain technology,this paper constructs a multi-dimensional dynamic supply chain financial risk control system.The system includes multi-dimensional dynamic supply chain financial risk control technology,a credit evaluation system,and a capital monitoring and early warning system.By constructing a multi-dimensional dynamic supply chain financial risk control system,effective risk complete monitoring and penetrating supervision can be achieved.At the same time,this paper introduces technologies such as machine learning and deep learning to build an effective risk control system,which is of great significance for reducing supply chain financial risks.
基金supported by a the National Research Foundation(NRF),funded by the Ministry of Science and ICT(RS-2023-00218476,RS-2024-00454619)the Cooperative Research Program for Agriculture Science and Technology Development(RS-2022-RD010165)+1 种基金the Ministry of Health&Welfare,Republic of Korea(RS-2022-KH128577)the BK21 FOUR Program of the Department of Agricultural Biotechnology,Seoul National University,Seoul,Korea.
文摘Background Despite growing concerns about the adverse effects of antibiotics in farm animals,there has been little investigation of the effects of florfenicol in laying hens.This study examined the effect of florfenicol on the intestinal homeostasis,immune system,and pathogen susceptibility of laying hens.Results The oral administration of florfenicol at field-relevant levels for 5 d resulted in a decrease in the gut microbiota genera Lactobacillus,Bacillus,and Bacteroides,indicating the development of intestinal dysbiosis.The dysbiosis led to decreased mRNA levels of key regulators peroxisome proliferator-activated receptor gamma(PPAR-γ)and hypoxia-inducible factor-1α(HIF-1α),compromising intestinal hypoxia.Intestinal homeostasis was also disrupted,with decreased expression of Occludin and Mucin 2(Muc2)genes combined with increased gut epithelial permeability.The breakdown in intestinal homeostasis and immune function provided a favorable environment for opportunistic bacteria like avian pathogenic Escherichia coli(APEC),culminating in systemic infection.Immunologically,florfenicol treatment resulted in increased proportion and absolute number of MRC1L-B^(+)monocytes/macrophages in the spleen,indicating an exacerbated infection.Furthermore,both the proportion and absolute number ofγδT cells in the lamina propria of the cecum decreased.Treatment with florfenicol reduced butyrate levels in the cecum.However,the administration of butyrate before and during florfenicol treatment restored factors associated with intestinal homeostasis,including PPAR-γ,Occludin,and Muc2,while partially restoring HIF-1α,normalized intestinal hypoxia and gut permeability,and reversed immune cell changes,suppressing APEC systemic infection.Conclusion The uncontrolled and widespread use of florfenicol can negatively affect intestinal health in chickens.Specifically,florfenicol was found to impair intestinal homeostasis and immune function in laying hens,including by reducing butyrate levels,thereby increasing their susceptibility to systemic APEC infection.The development of strategies for mitigating the adverse effects of florfenicol on gut health and pathogen susceptibility in laying hens is therefore essential.
文摘[Objective] The paper is to construct the logistics tracking management system of tropical agricultural products based on supply chain.[Method] With tropical agricultural products in Hainan as study object,based on logistics supply chain files and electronic tag coding of agricultural products,cold chain temperature and humidity monitoring,vehicle transportation positioning,data exchange of XML Web services and role-based permission dynamic allocation,the multi-level multi-permission and multi-role logistics tracking management system of tropical agricultural products has been established.[Result] The system constructs information exchange platform for various links of logistics supply chain of tropical agricultural products,which realizes the entire quality monitoring and information tracing of agricultural products,thus enhancing the competitiveness of supply chain in company.[Conclusion] The system has good application and extension prospect.
基金The National Natural Science Foundation of China(No.60903011)the Natural Science Foundation of Jiangsu Province(No.BK2009267)
文摘A new modular solution to the state explosion problem caused by the Markov-based modular solution of dynamic multiple-phased systems is proposed. First, the solution makes full use of the static parts of dynamic multiple-phased systems and constructs cross-phase dynamic modules by combining the dynamic modules of phase fault trees. Secondly, the system binary decision diagram （BDD） from a modularized multiple- phased system （MPS）is generated by using variable ordering and BDD operations. The computational formulations of the BDD node event probability are derived for various node links and the system reliability results are figured out. Finally, a hypothetical multiple-phased system is given to demonstrate the advantages of the dynamic modular solution when the Markov state space and the size of the system BDD are reduced.
文摘This article reviewed the inhibition mechanism of long chain fatty acid on the formation of anaerobic system, then thoroughly analyzed the inhibition factors of long chain fatty acid, and summarized the remission method to its inhibition, finally proposed some suggestions to further study on the influence of long chain fatty acid on anaerobic digestion system.
基金Supported by Central University Basic Research Operating Expenses Special Fund(XDJK2011C026)Southwest University Doctoral Fund(09BSR04)~~
文摘[Objective] This study aimed to optimize the PCR amplification conditions for random ssDNA pool in SELEX technology. [Method] L16（45） orthogonal experimental design was adopted for optimization of five important factors affecting PCR reaction system for random single-stranded DNA pool including Mg2＋ concentration, dNTP concentration, amount of Taq DNA polymerase, primer concentration and amount of random single-stranded DNA pool at four levels. Meanwhile, the annealing temperature and number of PCR reaction cycles were optimized to establish the optimal reaction system and PCR procedure. [Result] The optimal combination of PCR reaction system for random ssDNA pool was obtained, with a total system volume of 20 μl containing 2.0 μl of 10 × Buffer, 0.5 ng of random ssDNA pool, 2.5 mmol/L Mg2＋, 0.25 mmol/L dNTP Mixture, 0.6 μmol/L upstream and downstream primers and 1.5 U of Taq DNA polymerase; the optimal annealing temperature was 68 ℃ and the optimal number of cycles was 12. Under the above conditions, clear and stable bands with high specificity for random ssDNA pool were amplified. [Conclusion] This study laid the foundation for selection of parameters with higher specificity in SELEX technology.
