Bioactive ceramics have been used in bone tissue repair and regeneration.However,because of the complex in vivo osteogenesis process,long cycle,and difficulty of accurately tracking,the mechanism of interaction betwee...Bioactive ceramics have been used in bone tissue repair and regeneration.However,because of the complex in vivo osteogenesis process,long cycle,and difficulty of accurately tracking,the mechanism of interaction between materials and cells has yet to be fully understood,hindering its development.The ceramic microbridge micro-fluidic chip system may solve the problem and provide an in vitro method to simulate the microenvironment in vivo.Nevertheless,the complex microenvironment parameters of the chip system need to be studied in detail.Computer simulation bionics can provide clues for the setting of microenvironment parameters.This study used a computational bionic model to simulate the bone growth process in the presence of immune-related factors.The osteoblast differentiation of mesenchymal stem cells of calcium phosphate ceramics in a macrophage-dominated immune microenvironment was studied using a microfluidic chip system.The computational biomimetic model and microfluidic chip findings were basically consistent with the reported results of the animal experiments.These findings suggest that studying the osteogenic behavior of calcium phosphate ceramics using a microfluidic chip model is feasible.The method model provided in this study can be extended to other biomaterials,providing a viable path for their research and evaluation.展开更多
The development of intelligent control techniques provides powerful means for the control of machine tools. In this paper, a intelligent control technique and an algorithm for precision control of CNC grinding of cera...The development of intelligent control techniques provides powerful means for the control of machine tools. In this paper, a intelligent control technique and an algorithm for precision control of CNC grinding of ceramic chips are introduced. In the process of ceramic chip CNC grinding, the dimension of the chips tends to get larger and the dimensional error to exceed the tolerance as the number of the chips increases which are machined on the same part program. There are many factors leading to the occurrence of the error and the law of error variation is very complicated. With the introduced intelligent self learning error compensation technique, the CNC system can improve the control strategy to compensate the error automatically. The simulational result is also given.展开更多
An advanced direct chip attaching packaged two-dimensional ceramic thermal wind sensor is studied. The thermal wind sensor chip is fabricated by metal lift-off processes on the ceramic substrate. An advanced direct ch...An advanced direct chip attaching packaged two-dimensional ceramic thermal wind sensor is studied. The thermal wind sensor chip is fabricated by metal lift-off processes on the ceramic substrate. An advanced direct chip attaching （DCA） packaging is adopted and this new packaged method simplifies the processes of packaging further. Simulations of the advanced DCA packaged sensor based on computational fluid dynamics （CFD） model show the sensor can detect wind speed and direction effectively. The wind tunnel testing results show the advanced DCA packaged sensor can detect the wind direction from 0° to 360° and wind speed from 0 to 20 m/s with the error less than 0.5 m/s. The nonlinear fitting based least square method in Matlab is used to analyze the performance of the sensor.展开更多
In this paper, we present a 60 GHz substrate-integrated waveguide fed-steerable low-temperature cofired ceramics array. The antenna is suitable for transmitting and receiving on the 60 GHz wireless personal area netwo...In this paper, we present a 60 GHz substrate-integrated waveguide fed-steerable low-temperature cofired ceramics array. The antenna is suitable for transmitting and receiving on the 60 GHz wireless personal area network frequency band. The wireless system can be used for HDTV, high-data-rate networking up to 4.5 GBit/s, security and surveillance, and similar applications.展开更多
Bone is an important part of the human body structure and plays a vital role in human health.A microfluidic chip that can simulate the structure and function of bone will provide a platform for bone-related biomedical...Bone is an important part of the human body structure and plays a vital role in human health.A microfluidic chip that can simulate the structure and function of bone will provide a platform for bone-related biomedical research.Hydroxyapatite(HA),a bioactive ceramic material,has a similar structure and composition to bone mineralization products.In this study,we used HA as a microfluidic chip component to provide a highly bionic bone environment.HA substrates with different microchannel structures were printed by using ceramic stereolithography(SLA)technology,and the minimum trench width was 50μm.The HA substrate with microchannels was sealed by a thin polydimethylsiloxane(PDMS)layer to make a HA-PDMS microfluidic chip.Cell culture experiments demonstrated that compared with PDMS,HA was more conducive to the proliferation and osteogenic differentiation of the human foetal osteoblast cell line(hFOB).In addition,the concentration gradient of the model drug doxorubicin hydrochloride(DOX)was successfully generated on a Christmas tree structure HA-PDMS chip,and the half maximal inhibitory concentration(IC50)of DOX was determined.The findings of this study indicate that the HA-PDMS microfluidic chip has great potential in the field of high-throughput bonerelated drug screening and bone-related research.展开更多
基金supported by the National key research and development programs of China:2022YFC2405800Beijing Natural Science Foundation:L234022supported by China NMPA Research on performance and safety evaluation of innovative biomaterial medical devices:RS2024X004.
文摘Bioactive ceramics have been used in bone tissue repair and regeneration.However,because of the complex in vivo osteogenesis process,long cycle,and difficulty of accurately tracking,the mechanism of interaction between materials and cells has yet to be fully understood,hindering its development.The ceramic microbridge micro-fluidic chip system may solve the problem and provide an in vitro method to simulate the microenvironment in vivo.Nevertheless,the complex microenvironment parameters of the chip system need to be studied in detail.Computer simulation bionics can provide clues for the setting of microenvironment parameters.This study used a computational bionic model to simulate the bone growth process in the presence of immune-related factors.The osteoblast differentiation of mesenchymal stem cells of calcium phosphate ceramics in a macrophage-dominated immune microenvironment was studied using a microfluidic chip system.The computational biomimetic model and microfluidic chip findings were basically consistent with the reported results of the animal experiments.These findings suggest that studying the osteogenic behavior of calcium phosphate ceramics using a microfluidic chip model is feasible.The method model provided in this study can be extended to other biomaterials,providing a viable path for their research and evaluation.
文摘The development of intelligent control techniques provides powerful means for the control of machine tools. In this paper, a intelligent control technique and an algorithm for precision control of CNC grinding of ceramic chips are introduced. In the process of ceramic chip CNC grinding, the dimension of the chips tends to get larger and the dimensional error to exceed the tolerance as the number of the chips increases which are machined on the same part program. There are many factors leading to the occurrence of the error and the law of error variation is very complicated. With the introduced intelligent self learning error compensation technique, the CNC system can improve the control strategy to compensate the error automatically. The simulational result is also given.
基金supported by the National Natural Science Foundation of China(No.61076071)
文摘An advanced direct chip attaching packaged two-dimensional ceramic thermal wind sensor is studied. The thermal wind sensor chip is fabricated by metal lift-off processes on the ceramic substrate. An advanced direct chip attaching （DCA） packaging is adopted and this new packaged method simplifies the processes of packaging further. Simulations of the advanced DCA packaged sensor based on computational fluid dynamics （CFD） model show the sensor can detect wind speed and direction effectively. The wind tunnel testing results show the advanced DCA packaged sensor can detect the wind direction from 0° to 360° and wind speed from 0 to 20 m/s with the error less than 0.5 m/s. The nonlinear fitting based least square method in Matlab is used to analyze the performance of the sensor.
文摘In this paper, we present a 60 GHz substrate-integrated waveguide fed-steerable low-temperature cofired ceramics array. The antenna is suitable for transmitting and receiving on the 60 GHz wireless personal area network frequency band. The wireless system can be used for HDTV, high-data-rate networking up to 4.5 GBit/s, security and surveillance, and similar applications.
基金The authors gratefully acknowledge funding from the Shenzhen Science and Technology Program(JCYJ20170815153105076,GJHZ20180411143347603)National Natural Science Foundation of China(31770107 and 21874116)+3 种基金Science and Technology Program of Guangdong Province(2019B010941002,2017B090911008)Guangdong Natural Science Funds for Distinguished Young Scholars(2016A030306018)Science and Technology Program of Guangzhou(201804020060,202007020002)Outstanding Scholar Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory(2018GZR110102001)。
文摘Bone is an important part of the human body structure and plays a vital role in human health.A microfluidic chip that can simulate the structure and function of bone will provide a platform for bone-related biomedical research.Hydroxyapatite(HA),a bioactive ceramic material,has a similar structure and composition to bone mineralization products.In this study,we used HA as a microfluidic chip component to provide a highly bionic bone environment.HA substrates with different microchannel structures were printed by using ceramic stereolithography(SLA)technology,and the minimum trench width was 50μm.The HA substrate with microchannels was sealed by a thin polydimethylsiloxane(PDMS)layer to make a HA-PDMS microfluidic chip.Cell culture experiments demonstrated that compared with PDMS,HA was more conducive to the proliferation and osteogenic differentiation of the human foetal osteoblast cell line(hFOB).In addition,the concentration gradient of the model drug doxorubicin hydrochloride(DOX)was successfully generated on a Christmas tree structure HA-PDMS chip,and the half maximal inhibitory concentration(IC50)of DOX was determined.The findings of this study indicate that the HA-PDMS microfluidic chip has great potential in the field of high-throughput bonerelated drug screening and bone-related research.
